CN115812714A - Low-corrosivity endoscope disinfectant and preparation method thereof - Google Patents

Low-corrosivity endoscope disinfectant and preparation method thereof Download PDF

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CN115812714A
CN115812714A CN202211594211.3A CN202211594211A CN115812714A CN 115812714 A CN115812714 A CN 115812714A CN 202211594211 A CN202211594211 A CN 202211594211A CN 115812714 A CN115812714 A CN 115812714A
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CN115812714B (en
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王卫
施君君
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Nanjing Jusha Display Technology Co Ltd
Nanjing Jusha Medical Technology Co Ltd
Nanjing Jusha Commercial and Trading Co Ltd
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Nanjing Jusha Display Technology Co Ltd
Nanjing Jusha Medical Technology Co Ltd
Nanjing Jusha Commercial and Trading Co Ltd
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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract

The invention discloses a low-corrosivity endoscope disinfectant and a preparation method thereof, wherein the disinfectant comprises a liquid A and a liquid B, the liquid A is prepared from the following raw materials in percentage by weight: 0.1 to 30 percent of novel corrosion inhibitor, 0.1 to 10 percent of auxiliary surfactant, 0.01 to 5 percent of chelating agent, 1 to 50 percent of solvent, 0.1 to 20 percent of pH regulator, 0.1 to 20 percent of auxiliary agent and deionized water, wherein the novel corrosion inhibitor is a reaction product of blocked polyether and o-phenylenediamine derivative; the solution B is a peroxyacetic acid solution with the concentration of 5 to 35wt%. The invention can play a role in protecting instruments and has good disinfection effect.

Description

Low-corrosivity endoscope disinfectant and preparation method thereof
Technical Field
The invention belongs to the technical field of preparation of endoscope disinfectants, and relates to a low-corrosivity endoscope disinfectant and a preparation method thereof.
Background
At present, in the high-level disinfection of the digestive endoscopy, disinfectants such as o-phthalaldehyde, glutaraldehyde, peracetic acid, chlorine dioxide, electrolyzed oxidizing water and compound chlorine-containing disinfectant can be selected at will, but the use share in practical application is different, users prefer different disinfectants, and the advantages and the disadvantages of the disinfectants are different. According to statistics, the first 3 sites in the amount of the digestive endoscopy used for disinfection are glutaraldehyde, o-phthalaldehyde and peracetic acid, the recognition degree is high, and especially, peracetic acid is rapid in action, easy to wash and degrade and has an increasing trend in recent years.
The peroxyacetic acid has strong oxidizability, can oxidize proteins in bacteria to kill microorganisms, can achieve a sterilization effect, and has the synergistic effect of hydrogen peroxide in a system, but also has the defects of insufficient stability, high corrosivity and the like, and particularly the problem of high corrosivity of the peroxyacetic acid seriously troubles customers and manufacturers. The American endoscope Association (ASGE) and the Food and Drug Administration (FDA) do not recommend that high-level disinfectants or sterilizing agents are directly used for disinfection and sterilization of endoscopes, and the disinfectants or sterilizing agents can be adopted after the compatibility of instruments and sterilizing solutions is fully and comprehensively considered. The current 'requirement for sanitation of medical instrument disinfectants' in China also provides an 'no obvious corrosivity on the whole medical instrument and each component after long-term use' without an applicable evaluation method, which brings confusion to the selection of sterilizing agents for precise instruments such as endoscopes and the like.
Disclosure of Invention
The invention aims to overcome the defects in the prior art, and provides a low-corrosivity endoscope disinfectant and a preparation method thereof, which can play a role in protecting instruments and have a good disinfection effect.
In order to achieve the purpose, the invention is realized by adopting the following technical scheme:
a low-corrosivity endoscope disinfectant comprises a liquid A and a liquid B, wherein the liquid A is prepared from the following raw materials in percentage by weight: 0.1 to 30 percent of novel corrosion inhibitor, 0.1 to 10 percent of auxiliary surfactant, 0.01 to 5 percent of chelating agent, 1 to 50 percent of solvent, 0.1 to 20 percent of pH regulator, 0.1 to 20 percent of auxiliary agent and deionized water, wherein the novel corrosion inhibitor is a reaction product of blocked polyether and o-phenylenediamine derivative; the solution B is a peroxyacetic acid solution with the concentration of 5 to 35wt%.
Optionally, the molecular structural formula of the end-capped polyether is R 1 -(OC 3 H 6x (OC 2 H 4y -OR 2 ,R 1 Comprising C 3 ~C 18 The number of X is 1 to 6, the number of Y is 1 to 9 2 Comprising C 2 O 3 H or C 4 H 5 O 3
Optionally, the molecular structural formula of the o-phenylenediamine derivative is Ar- (NH) 2 ) 2 And Ar is an aromatic compound.
Optionally, the molar ratio of the capped polyether to the o-phenylenediamine derivative is.
Optionally, the co-surfactant comprises at least an amine oxide and an anionic or nonionic surfactant;
amine oxides include lauryl dimethyl amine oxide, myristyl dimethyl amine oxide, dimethyl coco amine oxide, cocamidopropyl dimethyl amine oxide, tallowamidopropyl dimethyl amine oxide; the anionic or nonionic surfactant comprises alkyl sulfate, alkyl phosphate, fatty alcohol polyoxyethylene ether carboxylate, alkenyl sulfonate, succinate sulfonate, alkyl glyceryl ether sulfate, lauryl alcohol sulfonate, sodium lauryl sulfate, alkylbenzene sulfonate, fatty alcohol polyoxyethylene ether, fatty acid methyl ester ethoxylate, and isomeric alcohol polyoxyethylene ether.
Optionally, the chelating agent includes hydroxyethylidene diphosphonic acid, ethylene diamine tetraacetic acid and its sodium salt, diethylenetriamine pentamethylene phosphonic acid, sodium ethylene diamine tetramethylene phosphonate, phosphates, silicates, sodium glucoheptonate, tetrasodium glutamate diacetate, trisodium methylglycinediacetate, citric acid and its salts, maleic acid, polyacrylic acid and one or more combinations of its sodium salts.
Optionally, the auxiliary agent includes one or more of benzotriazole, sodium molybdate, sulfonated lignin, polyethylenes, POCA, polyaspartic acid, chromate, molybdate, tungstate, vanadate, nitrite, borate, phosphate, and phosphorus-containing organic compounds.
Optionally, the solvent includes one or more of glycerol, propylene glycol, ethanol, isopropanol, diethylene glycol methyl ether, triethylene glycol methyl ether, diethylene glycol ethyl ether, triethylene glycol ethyl ether, ethylene glycol propyl ether, ethylene glycol butyl ether, diethylene glycol butyl ether, triethylene glycol butyl ether, ethylene glycol hexyl ether, diethylene glycol hexyl ether, ethylene glycol butyl ether acetate, diethylene glycol butyl ether acetate, ethylene glycol phenyl ether, propylene glycol methyl ether, dipropylene glycol methyl ether, tripropylene glycol methyl ether, propylene glycol propyl ether, dipropylene glycol propyl ether, propylene glycol butyl ether, dipropylene glycol butyl ether, tripropylene glycol butyl ether, propylene glycol methyl ether acetate, dipropylene glycol methyl ether acetate, propylene glycol diacetate, propylene glycol phenyl ether, dipropylene glycol dimethyl ether.
Optionally, the pH regulator includes one or more of sodium hydroxide, potassium hydroxide, carbonate, bicarbonate, boric acid, borax, potassium dihydrogen phosphate, disodium hydrogen phosphate, phosphoric acid, and citric acid.
A preparation method of a low-corrosivity endoscope disinfectant comprises the following steps:
mixing deionized water with the novel corrosion inhibitor, the solvent and the auxiliary agent at the temperature of 30-40 ℃, and obtaining a first premixed solution after dissolution;
mixing deionized water with an auxiliary surfactant, a pH regulator, a chelating agent and a corrosion inhibitor, and uniformly mixing to obtain a second premixed solution;
and mixing the first premixed solution, the second premixed solution and deionized water to obtain the low-corrosivity endoscope disinfectant.
Compared with the prior art, the invention has the following beneficial effects:
according to the low-corrosivity endoscope disinfectant and the preparation method thereof, the specific novel corrosion inhibitor is adopted, and the pH regulator and the corrosion inhibitor are compounded, so that the corrosivity to metal instruments such as anodized aluminum, brass, carbon steel, stainless steel and the like can be obviously reduced.
The liquid level of the mixed liquid A and the liquid B is clear and transparent, and the storage time is long;
the liquid A and the liquid B can be mixed and used, so that the use is convenient;
the preparation method is simple, reliable in performance and environment-friendly.
Detailed Description
The invention is further described below. The following examples are only for illustrating the technical solutions of the present invention more clearly, and the protection scope of the present invention is not limited thereby.
The endpoints of the ranges and any values disclosed herein are not limited to the precise range or value, and such ranges or values should be understood to encompass values close to those ranges or values. For ranges of values, between the endpoints of each of the ranges and the individual points, and between the individual points may be combined with each other to give one or more new ranges of values, and these ranges of values should be considered as specifically disclosed herein.
For the purposes of the present specification and appended claims, unless otherwise indicated, all numbers expressing quantities, percentages or proportions, and other numerical values used in the specification and appended claims, are to be understood as being modified in all instances by the term "about". Moreover, all ranges disclosed herein are inclusive of the endpoints and independently combinable.
Example one
A low-corrosivity endoscope disinfectant comprises a liquid A and a liquid B, wherein the liquid A is prepared from the following raw materials in percentage by weight: 1% of novel corrosion inhibitor, 1% of AO-455 auxiliary surfactant, 0.5% of LF221 auxiliary surfactant, 1% of STPP chelating agent, 1% of propylene glycol solvent, 0.5% of sodium hydroxide pH regulator, 0.1% of BTA aid and 94.9% of deionized water; the B liquid is selected from the winning PROXITANE 5 peracetic acid products, the content of the peracetic acid in the product is 5wt%.
The novel corrosion inhibitor is a reactant of the blocked polyether and the o-phenylenediamine derivative; the terminated polyether is RS507 terminated polyether of Zhongshan chemical industry Co., ltd, jiangsu province, RS507 is a compound of acetic acid terminated methyl allyl random copolymer polyether in hydrosilylation reaction, and the terminal of the RS507 isHaving a-COOH structure; o-phenylenediamine and its derivatives are selected from o-phenylenediamine; the reaction principle is that-COOH and-NH in the terminated polyether 2 Can be subjected to condensation reaction under the acidic catalysis condition to generate the novel benzimidazolyl-containing corrosion inhibitor.
The preparation method of the novel corrosion inhibitor comprises the following steps:
s1, adding 105g of o-phenylenediamine and 6 mol/L hydrochloric acid solution into a four-neck flask;
s2, respectively installing mechanical stirring, a reflux condenser tube, nitrogen protection and a constant-pressure dropping funnel on four mouths of a four-mouth flask, stirring and gradually heating to 120 ℃;
s3, after the o-phenylenediamine is completely dissolved, slowly dropping 100g of RS507 into the solution through a constant-pressure dropping funnel at a constant speed, and performing reflux reaction for 6 hours to obtain a uniform liquid product;
and S4, cooling the uniform liquid product to room temperature, filtering to remove precipitated solids, performing rotary evaporation on the residual liquid, and removing water to obtain a paste product, namely the novel corrosion inhibitor.
A preparation method of a low-corrosivity endoscope disinfectant comprises the following steps:
s1, mixing 500g of deionized water with a novel corrosion inhibitor, a solvent and an auxiliary agent at the temperature of 35 ℃, and obtaining a first premixed solution after dissolution;
s2, mixing 400g of deionized water with an auxiliary surfactant, a pH regulator, a chelating agent and a corrosion inhibitor, and uniformly mixing to obtain a second premixed solution;
and S3, mixing the first premixed liquid, the second premixed liquid and 59g of deionized water to obtain the low-corrosivity endoscope disinfectant.
Example two
A low-corrosivity endoscope disinfectant comprises a liquid A and a liquid B, wherein the liquid A is prepared from the following raw materials in percentage by weight: 2% of novel corrosion inhibitor, 1% of AO-455 auxiliary surfactant, 0.1% of LF221 auxiliary surfactant, 1% of HEDP chelating agent, 20% of glycerol solvent, 1.5% of potassium hydroxide pH regulator, 0.1% of BTA aid and 74.3% of deionized water; the B liquid is selected from the winning PROXITANE 5 peracetic acid products, the content of the peracetic acid in the product is 5wt%.
The novel corrosion inhibitor is a reactant of the blocked polyether and the o-phenylenediamine derivative; the end-capped polyether is RD698 end-capped polyether of Zhongshan chemical industry Co., ltd, jiangsu province, RD698 is an oxalic acid end-capped C10 fatty alcohol polyoxyethylene ether compound, and the tail end of the RD698 end-capped polyether is provided with a-COOH structure; selecting o-phenylenediamine and its derivatives; the reaction principle is that-COOH and-NH in the terminated polyether 2 Can be subjected to condensation reaction under the acidic catalysis condition to generate the novel benzimidazolyl-containing corrosion inhibitor.
The preparation method of the novel corrosion inhibitor comprises the following steps:
s1, adding 100g of o-phenylenediamine and 6 mol/L hydrochloric acid solution into a four-neck flask;
s2, respectively installing mechanical stirring, a reflux condenser tube, nitrogen protection and a constant-pressure dropping funnel on four mouths of a four-mouth flask, stirring and gradually heating to 120 ℃;
s3, after the o-phenylenediamine is completely dissolved, slowly dropping 100g of RD698 at a constant speed through a constant-pressure dropping funnel, and carrying out reflux reaction for 7 hours to obtain a uniform liquid product;
and S4, cooling the uniform liquid product to room temperature, filtering to remove precipitated solids, performing rotary evaporation on the residual liquid, and removing water to obtain a paste product, namely the novel corrosion inhibitor.
A preparation method of a low-corrosivity endoscope disinfectant comprises the following steps:
s1, mixing 400g of deionized water with a novel corrosion inhibitor, a solvent and an auxiliary agent at the temperature of 35 ℃, and obtaining a first premixed solution after dissolution is finished;
s2, mixing 300g of deionized water with an auxiliary surfactant, a pH regulator, a chelating agent and a corrosion inhibitor, and uniformly mixing to obtain a second premixed solution;
and S3, mixing the first premixed liquid, the second premixed liquid and 43g of deionized water to obtain the low-corrosivity endoscope disinfectant.
EXAMPLE III
The low-corrosivity endoscope disinfectant comprises a liquid A and a liquid B, wherein the liquid A is prepared from the following raw materials in percentage by weight: 30% of novel corrosion inhibitor, 1% of AO-455 cosurfactant, 0.1% of LF221 cosurfactant, 1% of HEDP chelating agent, 20% of glycerol solvent, 1.5% of potassium hydroxide pH regulator, 0.1% of BTA assistant and 46.3% of deionized water; the B liquid is selected from the winning PROXITANE 5 peracetic acid products, the content of the peracetic acid in the product is 5wt%.
The novel corrosion inhibitor is a reactant of the blocked polyether and the o-phenylenediamine derivative; the end-capped polyether is RD698 end-capped polyether of Zhongshan chemical industry Co., ltd, jiangsu province, RD698 is an oxalic acid end-capped C10 fatty alcohol polyoxyethylene ether compound, and the tail end of the RD698 end-capped polyether is provided with a-COOH structure; selecting o-phenylenediamine and its derivatives; the reaction principle is that-COOH and-NH in the terminated polyether 2 Can be subjected to condensation reaction under the acidic catalysis condition to generate the novel benzimidazolyl-containing corrosion inhibitor.
The preparation method of the novel corrosion inhibitor comprises the following steps:
s1, adding 500g of o-phenylenediamine and 6 mol/L hydrochloric acid solution into a four-neck flask;
s2, respectively installing a mechanical stirring device, a reflux condenser tube, a nitrogen protection device and a constant-pressure dropping funnel on four mouths of a four-mouth flask, stirring and gradually heating to 120 ℃;
s3, after the o-phenylenediamine is completely dissolved, slowly dropping 500g of RD698 at a constant speed through a constant-pressure dropping funnel, and carrying out reflux reaction for 7 hours to obtain a uniform liquid product;
and S4, cooling the uniform liquid product to room temperature, filtering to remove precipitated solids, performing rotary evaporation on the residual liquid, and removing water to obtain a paste product, namely the novel corrosion inhibitor.
A preparation method of a low-corrosivity endoscope disinfectant comprises the following steps:
s1, mixing 200g of deionized water, 300g of novel corrosion inhibitor, 200g of glycerol solvent and 1g of BTA aid at the temperature of 35 ℃, and obtaining a first premixed solution after dissolution;
s2, mixing 200g of deionized water with 10g of AO-455 auxiliary surfactant, 1g of LF221 auxiliary surfactant, 10g of HEDP chelating agent and 15g of potassium hydroxide pH regulator, and uniformly mixing to obtain a second premixed solution;
and S3, mixing the first premixed liquid, the second premixed liquid and 63g of deionized water to obtain the low-corrosivity endoscope disinfectant.
The first and second examples, together with the commercial disinfectants, were evaluated for their disinfecting effect and their corrosiveness to metals, and the results are shown in the following table,
table 1 is an evaluation of the corrosiveness of metals according to the sterilization specifications,
Figure SMS_1
table 2 shows the killing effect of Staphylococcus aureus according to the disinfection specifications
Figure SMS_2
Table 3 shows the results of the sterilization simulation in-situ test on the medical instruments in example 1
Figure SMS_3
Note: negative control sterile growth; the denominator is the number of test samples, and the numerator is the number of positive samples;
table 4 example 2 results of simulated field tests for sterilization of medical devices
Figure SMS_4
The above description is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, several modifications and variations can be made without departing from the technical principle of the present invention, and these modifications and variations should also be regarded as the protection scope of the present invention.

Claims (10)

1. A low-corrosiveness endoscope disinfectant is characterized in that: the disinfectant comprises a liquid A and a liquid B, wherein the liquid A is prepared from the following raw materials in percentage by weight: 0.1 to 30 percent of novel corrosion inhibitor, 0.1 to 10 percent of auxiliary surfactant, 0.01 to 5 percent of chelating agent, 1 to 50 percent of solvent, 0.1 to 20 percent of pH regulator, 0.1 to 20 percent of auxiliary agent and the balance of deionized water, wherein the novel corrosion inhibitor is a reaction product of blocked polyether and o-phenylenediamine derivative; the solution B is a peroxyacetic acid solution with the concentration of 5 to 35wt%.
2. The disinfectant for low corrosiveness endoscope according to claim 1, wherein: the molecular structural formula of the end-capped polyether is R 1 -(OC 3 H 6x (OC 2 H 4y -OR 2 ,R 1 Comprising C 3 ~C 18 The number of X is 1 to 6, the number of Y is 1 to 9 2 Comprising C 2 O 3 H or C 4 H 5 O 3
3. The disinfectant for low corrosiveness endoscope according to claim 1, wherein: the molecular structural formula of the o-phenylenediamine derivative is Ar- (NH) 2 ) 2 And Ar is an aromatic compound.
4. The disinfectant for low corrosiveness endoscope according to claim 1, wherein: the molar ratio of the end-capped polyether to the o-phenylenediamine derivative is 1 to 3.
5. The disinfectant for low corrosiveness endoscope according to claim 1, wherein: the co-surfactant comprises at least an amine oxide and an anionic or nonionic surfactant;
amine oxides include lauryl dimethyl amine oxide, myristyl dimethyl amine oxide, dimethyl coco amine oxide, cocamidopropyl dimethyl amine oxide, tallowamidopropyl dimethyl amine oxide; the anionic or nonionic surfactant comprises alkyl sulfate, alkyl phosphate, fatty alcohol polyoxyethylene ether carboxylate, alkenyl sulfonate, succinate sulfonate, alkyl glyceryl ether sulfate, lauryl alcohol sulfonate, sodium lauryl sulfate, alkylbenzene sulfonate, fatty alcohol polyoxyethylene ether, fatty acid methyl ester ethoxylate and isomeric alcohol polyoxyethylene ether.
6. The disinfectant for low corrosiveness endoscope according to claim 1, wherein: the chelating agent comprises one or more of hydroxyethylidene diphosphonic acid, ethylene diamine tetraacetic acid and sodium salt thereof, diethylenetriamine pentamethylene phosphonic acid, ethylene diamine tetramethylene phosphonic acid sodium, phosphates, silicates, sodium glucoheptonate, tetrasodium glutamate diacetate, trisodium methylglycinediacetate, citric acid and citrate, maleic acid, polyacrylic acid and sodium salt.
7. The disinfectant for low corrosiveness endoscope according to claim 1, wherein: the auxiliary agent comprises one or more of benzotriazole, sodium molybdate, sulfonated lignin, polyethylene, POCA, polyaspartic acid, chromate, molybdate, tungstate, vanadate, nitrite, borate, phosphate and phosphorus-containing organic compounds.
8. The disinfectant for low corrosiveness endoscope according to claim 1, wherein: the solvent comprises one or more of glycerol, propylene glycol, ethanol, isopropanol, diethylene glycol methyl ether, triethylene glycol methyl ether, diethylene glycol ethyl ether, triethylene glycol ethyl ether, ethylene glycol propyl ether, ethylene glycol butyl ether, diethylene glycol butyl ether, triethylene glycol butyl ether, ethylene glycol hexyl ether, diethylene glycol hexyl ether, ethylene glycol butyl ether acetate, diethylene glycol butyl ether acetate, ethylene glycol phenyl ether, propylene glycol methyl ether, dipropylene glycol methyl ether, tripropylene glycol methyl ether, propylene glycol propyl ether, dipropylene glycol propyl ether, propylene glycol butyl ether, dipropylene glycol butyl ether, tripropylene glycol butyl ether, propylene glycol methyl ether acetate, dipropylene glycol methyl ether acetate, propylene glycol diacetate, propylene glycol phenyl ether, and dipropylene glycol dimethyl ether.
9. The disinfectant for low corrosiveness endoscope according to claim 1, wherein: the pH regulator comprises one or more of sodium hydroxide, potassium hydroxide, carbonate, bicarbonate, boric acid, borax, potassium dihydrogen phosphate, disodium hydrogen phosphate, phosphoric acid and citric acid.
10. A method for preparing a disinfectant for a low corrosiveness endoscope according to any of claims 1-9, comprising:
mixing deionized water with the novel corrosion inhibitor, the solvent and the auxiliary agent at the temperature of 30-40 ℃, and obtaining a first premixed solution after dissolution;
mixing deionized water with an auxiliary surfactant, a pH regulator, a chelating agent and a corrosion inhibitor, and uniformly mixing to obtain a second premixed solution;
and mixing the first premixed solution, the second premixed solution and deionized water to obtain the low-corrosivity endoscope disinfectant.
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