CN115812714A - Low-corrosivity endoscope disinfectant and preparation method thereof - Google Patents
Low-corrosivity endoscope disinfectant and preparation method thereof Download PDFInfo
- Publication number
- CN115812714A CN115812714A CN202211594211.3A CN202211594211A CN115812714A CN 115812714 A CN115812714 A CN 115812714A CN 202211594211 A CN202211594211 A CN 202211594211A CN 115812714 A CN115812714 A CN 115812714A
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- Prior art keywords
- ether
- disinfectant
- acid
- percent
- low
- Prior art date
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- 239000000645 desinfectant Substances 0.000 title claims abstract description 40
- 238000002360 preparation method Methods 0.000 title abstract description 15
- 239000007788 liquid Substances 0.000 claims abstract description 35
- 230000007797 corrosion Effects 0.000 claims abstract description 32
- 238000005260 corrosion Methods 0.000 claims abstract description 32
- 239000003112 inhibitor Substances 0.000 claims abstract description 32
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical group CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 claims abstract description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 25
- 239000004721 Polyphenylene oxide Substances 0.000 claims abstract description 22
- 229920000570 polyether Polymers 0.000 claims abstract description 22
- 239000008367 deionised water Substances 0.000 claims abstract description 21
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 21
- 239000004094 surface-active agent Substances 0.000 claims abstract description 15
- 239000002738 chelating agent Substances 0.000 claims abstract description 13
- 239000002904 solvent Substances 0.000 claims abstract description 13
- 150000004987 o-phenylenediamines Chemical class 0.000 claims abstract description 10
- 239000012752 auxiliary agent Substances 0.000 claims abstract description 9
- 239000002994 raw material Substances 0.000 claims abstract description 6
- 239000007795 chemical reaction product Substances 0.000 claims abstract description 3
- 238000002156 mixing Methods 0.000 claims description 20
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 15
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 15
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 12
- -1 alkyl phosphate Chemical compound 0.000 claims description 10
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 8
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 8
- 229910019142 PO4 Inorganic materials 0.000 claims description 6
- QRUDEWIWKLJBPS-UHFFFAOYSA-N benzotriazole Chemical compound C1=CC=C2N[N][N]C2=C1 QRUDEWIWKLJBPS-UHFFFAOYSA-N 0.000 claims description 6
- 150000002191 fatty alcohols Chemical class 0.000 claims description 6
- 235000021317 phosphate Nutrition 0.000 claims description 6
- 238000004090 dissolution Methods 0.000 claims description 5
- ARXJGSRGQADJSQ-UHFFFAOYSA-N 1-methoxypropan-2-ol Chemical compound COCC(C)O ARXJGSRGQADJSQ-UHFFFAOYSA-N 0.000 claims description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 4
- 150000001412 amines Chemical class 0.000 claims description 4
- 125000000129 anionic group Chemical group 0.000 claims description 4
- 239000003945 anionic surfactant Substances 0.000 claims description 4
- ONLRKTIYOMZEJM-UHFFFAOYSA-N n-methylmethanamine oxide Chemical compound C[NH+](C)[O-] ONLRKTIYOMZEJM-UHFFFAOYSA-N 0.000 claims description 4
- 239000002736 nonionic surfactant Substances 0.000 claims description 4
- 239000010452 phosphate Substances 0.000 claims description 4
- 159000000000 sodium salts Chemical class 0.000 claims description 4
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims description 4
- BAERPNBPLZWCES-UHFFFAOYSA-N (2-hydroxy-1-phosphonoethyl)phosphonic acid Chemical compound OCC(P(O)(O)=O)P(O)(O)=O BAERPNBPLZWCES-UHFFFAOYSA-N 0.000 claims description 2
- CUVLMZNMSPJDON-UHFFFAOYSA-N 1-(1-butoxypropan-2-yloxy)propan-2-ol Chemical compound CCCCOCC(C)OCC(C)O CUVLMZNMSPJDON-UHFFFAOYSA-N 0.000 claims description 2
- LAVARTIQQDZFNT-UHFFFAOYSA-N 1-(1-methoxypropan-2-yloxy)propan-2-yl acetate Chemical compound COCC(C)OCC(C)OC(C)=O LAVARTIQQDZFNT-UHFFFAOYSA-N 0.000 claims description 2
- QGJDXUIYIUGQGO-UHFFFAOYSA-N 1-[2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoyl]pyrrolidine-2-carboxylic acid Chemical compound CC(C)(C)OC(=O)NC(C)C(=O)N1CCCC1C(O)=O QGJDXUIYIUGQGO-UHFFFAOYSA-N 0.000 claims description 2
- RWNUSVWFHDHRCJ-UHFFFAOYSA-N 1-butoxypropan-2-ol Chemical compound CCCCOCC(C)O RWNUSVWFHDHRCJ-UHFFFAOYSA-N 0.000 claims description 2
- IBLKWZIFZMJLFL-UHFFFAOYSA-N 1-phenoxypropan-2-ol Chemical compound CC(O)COC1=CC=CC=C1 IBLKWZIFZMJLFL-UHFFFAOYSA-N 0.000 claims description 2
- FENFUOGYJVOCRY-UHFFFAOYSA-N 1-propoxypropan-2-ol Chemical compound CCCOCC(C)O FENFUOGYJVOCRY-UHFFFAOYSA-N 0.000 claims description 2
- OAYXUHPQHDHDDZ-UHFFFAOYSA-N 2-(2-butoxyethoxy)ethanol Chemical compound CCCCOCCOCCO OAYXUHPQHDHDDZ-UHFFFAOYSA-N 0.000 claims description 2
- VXQBJTKSVGFQOL-UHFFFAOYSA-N 2-(2-butoxyethoxy)ethyl acetate Chemical compound CCCCOCCOCCOC(C)=O VXQBJTKSVGFQOL-UHFFFAOYSA-N 0.000 claims description 2
- GZMAAYIALGURDQ-UHFFFAOYSA-N 2-(2-hexoxyethoxy)ethanol Chemical compound CCCCCCOCCOCCO GZMAAYIALGURDQ-UHFFFAOYSA-N 0.000 claims description 2
- SBASXUCJHJRPEV-UHFFFAOYSA-N 2-(2-methoxyethoxy)ethanol Chemical compound COCCOCCO SBASXUCJHJRPEV-UHFFFAOYSA-N 0.000 claims description 2
- CUDYYMUUJHLCGZ-UHFFFAOYSA-N 2-(2-methoxypropoxy)propan-1-ol Chemical compound COC(C)COC(C)CO CUDYYMUUJHLCGZ-UHFFFAOYSA-N 0.000 claims description 2
- XYVAYAJYLWYJJN-UHFFFAOYSA-N 2-(2-propoxypropoxy)propan-1-ol Chemical compound CCCOC(C)COC(C)CO XYVAYAJYLWYJJN-UHFFFAOYSA-N 0.000 claims description 2
- COBPKKZHLDDMTB-UHFFFAOYSA-N 2-[2-(2-butoxyethoxy)ethoxy]ethanol Chemical compound CCCCOCCOCCOCCO COBPKKZHLDDMTB-UHFFFAOYSA-N 0.000 claims description 2
- WFSMVVDJSNMRAR-UHFFFAOYSA-N 2-[2-(2-ethoxyethoxy)ethoxy]ethanol Chemical compound CCOCCOCCOCCO WFSMVVDJSNMRAR-UHFFFAOYSA-N 0.000 claims description 2
- WAEVWDZKMBQDEJ-UHFFFAOYSA-N 2-[2-(2-methoxypropoxy)propoxy]propan-1-ol Chemical compound COC(C)COC(C)COC(C)CO WAEVWDZKMBQDEJ-UHFFFAOYSA-N 0.000 claims description 2
- POAOYUHQDCAZBD-UHFFFAOYSA-N 2-butoxyethanol Chemical compound CCCCOCCO POAOYUHQDCAZBD-UHFFFAOYSA-N 0.000 claims description 2
- NQBXSWAWVZHKBZ-UHFFFAOYSA-N 2-butoxyethyl acetate Chemical compound CCCCOCCOC(C)=O NQBXSWAWVZHKBZ-UHFFFAOYSA-N 0.000 claims description 2
- UPGSWASWQBLSKZ-UHFFFAOYSA-N 2-hexoxyethanol Chemical compound CCCCCCOCCO UPGSWASWQBLSKZ-UHFFFAOYSA-N 0.000 claims description 2
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 2
- YEYKMVJDLWJFOA-UHFFFAOYSA-N 2-propoxyethanol Chemical compound CCCOCCO YEYKMVJDLWJFOA-UHFFFAOYSA-N 0.000 claims description 2
- VATRWWPJWVCZTA-UHFFFAOYSA-N 3-oxo-n-[2-(trifluoromethyl)phenyl]butanamide Chemical compound CC(=O)CC(=O)NC1=CC=CC=C1C(F)(F)F VATRWWPJWVCZTA-UHFFFAOYSA-N 0.000 claims description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims description 2
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 2
- 229920001732 Lignosulfonate Polymers 0.000 claims description 2
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 claims description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 2
- 229920001091 Poly(octyl cyanoacrylate) Polymers 0.000 claims description 2
- 229920000805 Polyaspartic acid Polymers 0.000 claims description 2
- 239000004698 Polyethylene Substances 0.000 claims description 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 2
- 229920002125 Sokalan® Polymers 0.000 claims description 2
- RNFAKTRFMQEEQE-UHFFFAOYSA-N Tripropylene glycol butyl ether Chemical compound CCCCOC(CC)OC(C)COC(O)CC RNFAKTRFMQEEQE-UHFFFAOYSA-N 0.000 claims description 2
- PDIZYYQQWUOPPK-UHFFFAOYSA-N acetic acid;2-(methylamino)acetic acid Chemical compound CC(O)=O.CC(O)=O.CNCC(O)=O PDIZYYQQWUOPPK-UHFFFAOYSA-N 0.000 claims description 2
- 150000008051 alkyl sulfates Chemical class 0.000 claims description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 2
- 150000001491 aromatic compounds Chemical group 0.000 claims description 2
- 239000012964 benzotriazole Substances 0.000 claims description 2
- 229910021538 borax Inorganic materials 0.000 claims description 2
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 2
- 239000004327 boric acid Substances 0.000 claims description 2
- 235000010338 boric acid Nutrition 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 150000007942 carboxylates Chemical class 0.000 claims description 2
- ZCDOYSPFYFSLEW-UHFFFAOYSA-N chromate(2-) Chemical compound [O-][Cr]([O-])(=O)=O ZCDOYSPFYFSLEW-UHFFFAOYSA-N 0.000 claims description 2
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 claims description 2
- 229940090960 diethylenetriamine pentamethylene phosphonic acid Drugs 0.000 claims description 2
- UYAAVKFHBMJOJZ-UHFFFAOYSA-N diimidazo[1,3-b:1',3'-e]pyrazine-5,10-dione Chemical compound O=C1C2=CN=CN2C(=O)C2=CN=CN12 UYAAVKFHBMJOJZ-UHFFFAOYSA-N 0.000 claims description 2
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 2
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 claims description 2
- SYELZBGXAIXKHU-UHFFFAOYSA-N dodecyldimethylamine N-oxide Chemical compound CCCCCCCCCCCC[N+](C)(C)[O-] SYELZBGXAIXKHU-UHFFFAOYSA-N 0.000 claims description 2
- DUYCTCQXNHFCSJ-UHFFFAOYSA-N dtpmp Chemical compound OP(=O)(O)CN(CP(O)(O)=O)CCN(CP(O)(=O)O)CCN(CP(O)(O)=O)CP(O)(O)=O DUYCTCQXNHFCSJ-UHFFFAOYSA-N 0.000 claims description 2
- 229960001484 edetic acid Drugs 0.000 claims description 2
- DNORZUSMZSZZKU-UHFFFAOYSA-N ethyl 2-[5-(4-chlorophenyl)pentyl]oxirane-2-carboxylate Chemical compound C=1C=C(Cl)C=CC=1CCCCCC1(C(=O)OCC)CO1 DNORZUSMZSZZKU-UHFFFAOYSA-N 0.000 claims description 2
- 235000019387 fatty acid methyl ester Nutrition 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 235000019357 lignosulphonate Nutrition 0.000 claims description 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 2
- 239000011976 maleic acid Substances 0.000 claims description 2
- MEFBJEMVZONFCJ-UHFFFAOYSA-N molybdate Chemical compound [O-][Mo]([O-])(=O)=O MEFBJEMVZONFCJ-UHFFFAOYSA-N 0.000 claims description 2
- 229910000402 monopotassium phosphate Inorganic materials 0.000 claims description 2
- 235000019796 monopotassium phosphate Nutrition 0.000 claims description 2
- ONHFWHCMZAJCFB-UHFFFAOYSA-N myristamine oxide Chemical compound CCCCCCCCCCCCCC[N+](C)(C)[O-] ONHFWHCMZAJCFB-UHFFFAOYSA-N 0.000 claims description 2
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- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 2
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- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 claims description 2
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- 235000015393 sodium molybdate Nutrition 0.000 claims description 2
- TVXXNOYZHKPKGW-UHFFFAOYSA-N sodium molybdate (anhydrous) Chemical compound [Na+].[Na+].[O-][Mo]([O-])(=O)=O TVXXNOYZHKPKGW-UHFFFAOYSA-N 0.000 claims description 2
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- 229940061605 tetrasodium glutamate diacetate Drugs 0.000 claims description 2
- UZVUJVFQFNHRSY-OUTKXMMCSA-J tetrasodium;(2s)-2-[bis(carboxylatomethyl)amino]pentanedioate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CC[C@@H](C([O-])=O)N(CC([O-])=O)CC([O-])=O UZVUJVFQFNHRSY-OUTKXMMCSA-J 0.000 claims description 2
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- 239000013642 negative control Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- HWGNBUXHKFFFIH-UHFFFAOYSA-I pentasodium;[oxido(phosphonatooxy)phosphoryl] phosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O HWGNBUXHKFFFIH-UHFFFAOYSA-I 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 229920005604 random copolymer Polymers 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 235000019832 sodium triphosphate Nutrition 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
The invention discloses a low-corrosivity endoscope disinfectant and a preparation method thereof, wherein the disinfectant comprises a liquid A and a liquid B, the liquid A is prepared from the following raw materials in percentage by weight: 0.1 to 30 percent of novel corrosion inhibitor, 0.1 to 10 percent of auxiliary surfactant, 0.01 to 5 percent of chelating agent, 1 to 50 percent of solvent, 0.1 to 20 percent of pH regulator, 0.1 to 20 percent of auxiliary agent and deionized water, wherein the novel corrosion inhibitor is a reaction product of blocked polyether and o-phenylenediamine derivative; the solution B is a peroxyacetic acid solution with the concentration of 5 to 35wt%. The invention can play a role in protecting instruments and has good disinfection effect.
Description
Technical Field
The invention belongs to the technical field of preparation of endoscope disinfectants, and relates to a low-corrosivity endoscope disinfectant and a preparation method thereof.
Background
At present, in the high-level disinfection of the digestive endoscopy, disinfectants such as o-phthalaldehyde, glutaraldehyde, peracetic acid, chlorine dioxide, electrolyzed oxidizing water and compound chlorine-containing disinfectant can be selected at will, but the use share in practical application is different, users prefer different disinfectants, and the advantages and the disadvantages of the disinfectants are different. According to statistics, the first 3 sites in the amount of the digestive endoscopy used for disinfection are glutaraldehyde, o-phthalaldehyde and peracetic acid, the recognition degree is high, and especially, peracetic acid is rapid in action, easy to wash and degrade and has an increasing trend in recent years.
The peroxyacetic acid has strong oxidizability, can oxidize proteins in bacteria to kill microorganisms, can achieve a sterilization effect, and has the synergistic effect of hydrogen peroxide in a system, but also has the defects of insufficient stability, high corrosivity and the like, and particularly the problem of high corrosivity of the peroxyacetic acid seriously troubles customers and manufacturers. The American endoscope Association (ASGE) and the Food and Drug Administration (FDA) do not recommend that high-level disinfectants or sterilizing agents are directly used for disinfection and sterilization of endoscopes, and the disinfectants or sterilizing agents can be adopted after the compatibility of instruments and sterilizing solutions is fully and comprehensively considered. The current 'requirement for sanitation of medical instrument disinfectants' in China also provides an 'no obvious corrosivity on the whole medical instrument and each component after long-term use' without an applicable evaluation method, which brings confusion to the selection of sterilizing agents for precise instruments such as endoscopes and the like.
Disclosure of Invention
The invention aims to overcome the defects in the prior art, and provides a low-corrosivity endoscope disinfectant and a preparation method thereof, which can play a role in protecting instruments and have a good disinfection effect.
In order to achieve the purpose, the invention is realized by adopting the following technical scheme:
a low-corrosivity endoscope disinfectant comprises a liquid A and a liquid B, wherein the liquid A is prepared from the following raw materials in percentage by weight: 0.1 to 30 percent of novel corrosion inhibitor, 0.1 to 10 percent of auxiliary surfactant, 0.01 to 5 percent of chelating agent, 1 to 50 percent of solvent, 0.1 to 20 percent of pH regulator, 0.1 to 20 percent of auxiliary agent and deionized water, wherein the novel corrosion inhibitor is a reaction product of blocked polyether and o-phenylenediamine derivative; the solution B is a peroxyacetic acid solution with the concentration of 5 to 35wt%.
Optionally, the molecular structural formula of the end-capped polyether is R 1 -（OC 3 H 6 ） x （OC 2 H 4 ） y -OR 2 ，R 1 Comprising C 3 ~C 18 The number of X is 1 to 6, the number of Y is 1 to 9 2 Comprising C 2 O 3 H or C 4 H 5 O 3 。
Optionally, the molecular structural formula of the o-phenylenediamine derivative is Ar- (NH) 2 ) 2 And Ar is an aromatic compound.
Optionally, the molar ratio of the capped polyether to the o-phenylenediamine derivative is.
Optionally, the co-surfactant comprises at least an amine oxide and an anionic or nonionic surfactant;
amine oxides include lauryl dimethyl amine oxide, myristyl dimethyl amine oxide, dimethyl coco amine oxide, cocamidopropyl dimethyl amine oxide, tallowamidopropyl dimethyl amine oxide; the anionic or nonionic surfactant comprises alkyl sulfate, alkyl phosphate, fatty alcohol polyoxyethylene ether carboxylate, alkenyl sulfonate, succinate sulfonate, alkyl glyceryl ether sulfate, lauryl alcohol sulfonate, sodium lauryl sulfate, alkylbenzene sulfonate, fatty alcohol polyoxyethylene ether, fatty acid methyl ester ethoxylate, and isomeric alcohol polyoxyethylene ether.
Optionally, the chelating agent includes hydroxyethylidene diphosphonic acid, ethylene diamine tetraacetic acid and its sodium salt, diethylenetriamine pentamethylene phosphonic acid, sodium ethylene diamine tetramethylene phosphonate, phosphates, silicates, sodium glucoheptonate, tetrasodium glutamate diacetate, trisodium methylglycinediacetate, citric acid and its salts, maleic acid, polyacrylic acid and one or more combinations of its sodium salts.
Optionally, the auxiliary agent includes one or more of benzotriazole, sodium molybdate, sulfonated lignin, polyethylenes, POCA, polyaspartic acid, chromate, molybdate, tungstate, vanadate, nitrite, borate, phosphate, and phosphorus-containing organic compounds.
Optionally, the solvent includes one or more of glycerol, propylene glycol, ethanol, isopropanol, diethylene glycol methyl ether, triethylene glycol methyl ether, diethylene glycol ethyl ether, triethylene glycol ethyl ether, ethylene glycol propyl ether, ethylene glycol butyl ether, diethylene glycol butyl ether, triethylene glycol butyl ether, ethylene glycol hexyl ether, diethylene glycol hexyl ether, ethylene glycol butyl ether acetate, diethylene glycol butyl ether acetate, ethylene glycol phenyl ether, propylene glycol methyl ether, dipropylene glycol methyl ether, tripropylene glycol methyl ether, propylene glycol propyl ether, dipropylene glycol propyl ether, propylene glycol butyl ether, dipropylene glycol butyl ether, tripropylene glycol butyl ether, propylene glycol methyl ether acetate, dipropylene glycol methyl ether acetate, propylene glycol diacetate, propylene glycol phenyl ether, dipropylene glycol dimethyl ether.
Optionally, the pH regulator includes one or more of sodium hydroxide, potassium hydroxide, carbonate, bicarbonate, boric acid, borax, potassium dihydrogen phosphate, disodium hydrogen phosphate, phosphoric acid, and citric acid.
A preparation method of a low-corrosivity endoscope disinfectant comprises the following steps:
mixing deionized water with the novel corrosion inhibitor, the solvent and the auxiliary agent at the temperature of 30-40 ℃, and obtaining a first premixed solution after dissolution;
mixing deionized water with an auxiliary surfactant, a pH regulator, a chelating agent and a corrosion inhibitor, and uniformly mixing to obtain a second premixed solution;
and mixing the first premixed solution, the second premixed solution and deionized water to obtain the low-corrosivity endoscope disinfectant.
Compared with the prior art, the invention has the following beneficial effects:
according to the low-corrosivity endoscope disinfectant and the preparation method thereof, the specific novel corrosion inhibitor is adopted, and the pH regulator and the corrosion inhibitor are compounded, so that the corrosivity to metal instruments such as anodized aluminum, brass, carbon steel, stainless steel and the like can be obviously reduced.
The liquid level of the mixed liquid A and the liquid B is clear and transparent, and the storage time is long;
the liquid A and the liquid B can be mixed and used, so that the use is convenient;
the preparation method is simple, reliable in performance and environment-friendly.
Detailed Description
The invention is further described below. The following examples are only for illustrating the technical solutions of the present invention more clearly, and the protection scope of the present invention is not limited thereby.
The endpoints of the ranges and any values disclosed herein are not limited to the precise range or value, and such ranges or values should be understood to encompass values close to those ranges or values. For ranges of values, between the endpoints of each of the ranges and the individual points, and between the individual points may be combined with each other to give one or more new ranges of values, and these ranges of values should be considered as specifically disclosed herein.
For the purposes of the present specification and appended claims, unless otherwise indicated, all numbers expressing quantities, percentages or proportions, and other numerical values used in the specification and appended claims, are to be understood as being modified in all instances by the term "about". Moreover, all ranges disclosed herein are inclusive of the endpoints and independently combinable.
Example one
A low-corrosivity endoscope disinfectant comprises a liquid A and a liquid B, wherein the liquid A is prepared from the following raw materials in percentage by weight: 1% of novel corrosion inhibitor, 1% of AO-455 auxiliary surfactant, 0.5% of LF221 auxiliary surfactant, 1% of STPP chelating agent, 1% of propylene glycol solvent, 0.5% of sodium hydroxide pH regulator, 0.1% of BTA aid and 94.9% of deionized water; the B liquid is selected from the winning PROXITANE 5 peracetic acid products, the content of the peracetic acid in the product is 5wt%.
The novel corrosion inhibitor is a reactant of the blocked polyether and the o-phenylenediamine derivative; the terminated polyether is RS507 terminated polyether of Zhongshan chemical industry Co., ltd, jiangsu province, RS507 is a compound of acetic acid terminated methyl allyl random copolymer polyether in hydrosilylation reaction, and the terminal of the RS507 isHaving a-COOH structure; o-phenylenediamine and its derivatives are selected from o-phenylenediamine; the reaction principle is that-COOH and-NH in the terminated polyether 2 Can be subjected to condensation reaction under the acidic catalysis condition to generate the novel benzimidazolyl-containing corrosion inhibitor.
The preparation method of the novel corrosion inhibitor comprises the following steps:
s1, adding 105g of o-phenylenediamine and 6 mol/L hydrochloric acid solution into a four-neck flask;
s2, respectively installing mechanical stirring, a reflux condenser tube, nitrogen protection and a constant-pressure dropping funnel on four mouths of a four-mouth flask, stirring and gradually heating to 120 ℃;
s3, after the o-phenylenediamine is completely dissolved, slowly dropping 100g of RS507 into the solution through a constant-pressure dropping funnel at a constant speed, and performing reflux reaction for 6 hours to obtain a uniform liquid product;
and S4, cooling the uniform liquid product to room temperature, filtering to remove precipitated solids, performing rotary evaporation on the residual liquid, and removing water to obtain a paste product, namely the novel corrosion inhibitor.
A preparation method of a low-corrosivity endoscope disinfectant comprises the following steps:
s1, mixing 500g of deionized water with a novel corrosion inhibitor, a solvent and an auxiliary agent at the temperature of 35 ℃, and obtaining a first premixed solution after dissolution;
s2, mixing 400g of deionized water with an auxiliary surfactant, a pH regulator, a chelating agent and a corrosion inhibitor, and uniformly mixing to obtain a second premixed solution;
and S3, mixing the first premixed liquid, the second premixed liquid and 59g of deionized water to obtain the low-corrosivity endoscope disinfectant.
Example two
A low-corrosivity endoscope disinfectant comprises a liquid A and a liquid B, wherein the liquid A is prepared from the following raw materials in percentage by weight: 2% of novel corrosion inhibitor, 1% of AO-455 auxiliary surfactant, 0.1% of LF221 auxiliary surfactant, 1% of HEDP chelating agent, 20% of glycerol solvent, 1.5% of potassium hydroxide pH regulator, 0.1% of BTA aid and 74.3% of deionized water; the B liquid is selected from the winning PROXITANE 5 peracetic acid products, the content of the peracetic acid in the product is 5wt%.
The novel corrosion inhibitor is a reactant of the blocked polyether and the o-phenylenediamine derivative; the end-capped polyether is RD698 end-capped polyether of Zhongshan chemical industry Co., ltd, jiangsu province, RD698 is an oxalic acid end-capped C10 fatty alcohol polyoxyethylene ether compound, and the tail end of the RD698 end-capped polyether is provided with a-COOH structure; selecting o-phenylenediamine and its derivatives; the reaction principle is that-COOH and-NH in the terminated polyether 2 Can be subjected to condensation reaction under the acidic catalysis condition to generate the novel benzimidazolyl-containing corrosion inhibitor.
The preparation method of the novel corrosion inhibitor comprises the following steps:
s1, adding 100g of o-phenylenediamine and 6 mol/L hydrochloric acid solution into a four-neck flask;
s2, respectively installing mechanical stirring, a reflux condenser tube, nitrogen protection and a constant-pressure dropping funnel on four mouths of a four-mouth flask, stirring and gradually heating to 120 ℃;
s3, after the o-phenylenediamine is completely dissolved, slowly dropping 100g of RD698 at a constant speed through a constant-pressure dropping funnel, and carrying out reflux reaction for 7 hours to obtain a uniform liquid product;
and S4, cooling the uniform liquid product to room temperature, filtering to remove precipitated solids, performing rotary evaporation on the residual liquid, and removing water to obtain a paste product, namely the novel corrosion inhibitor.
A preparation method of a low-corrosivity endoscope disinfectant comprises the following steps:
s1, mixing 400g of deionized water with a novel corrosion inhibitor, a solvent and an auxiliary agent at the temperature of 35 ℃, and obtaining a first premixed solution after dissolution is finished;
s2, mixing 300g of deionized water with an auxiliary surfactant, a pH regulator, a chelating agent and a corrosion inhibitor, and uniformly mixing to obtain a second premixed solution;
and S3, mixing the first premixed liquid, the second premixed liquid and 43g of deionized water to obtain the low-corrosivity endoscope disinfectant.
EXAMPLE III
The low-corrosivity endoscope disinfectant comprises a liquid A and a liquid B, wherein the liquid A is prepared from the following raw materials in percentage by weight: 30% of novel corrosion inhibitor, 1% of AO-455 cosurfactant, 0.1% of LF221 cosurfactant, 1% of HEDP chelating agent, 20% of glycerol solvent, 1.5% of potassium hydroxide pH regulator, 0.1% of BTA assistant and 46.3% of deionized water; the B liquid is selected from the winning PROXITANE 5 peracetic acid products, the content of the peracetic acid in the product is 5wt%.
The novel corrosion inhibitor is a reactant of the blocked polyether and the o-phenylenediamine derivative; the end-capped polyether is RD698 end-capped polyether of Zhongshan chemical industry Co., ltd, jiangsu province, RD698 is an oxalic acid end-capped C10 fatty alcohol polyoxyethylene ether compound, and the tail end of the RD698 end-capped polyether is provided with a-COOH structure; selecting o-phenylenediamine and its derivatives; the reaction principle is that-COOH and-NH in the terminated polyether 2 Can be subjected to condensation reaction under the acidic catalysis condition to generate the novel benzimidazolyl-containing corrosion inhibitor.
The preparation method of the novel corrosion inhibitor comprises the following steps:
s1, adding 500g of o-phenylenediamine and 6 mol/L hydrochloric acid solution into a four-neck flask;
s2, respectively installing a mechanical stirring device, a reflux condenser tube, a nitrogen protection device and a constant-pressure dropping funnel on four mouths of a four-mouth flask, stirring and gradually heating to 120 ℃;
s3, after the o-phenylenediamine is completely dissolved, slowly dropping 500g of RD698 at a constant speed through a constant-pressure dropping funnel, and carrying out reflux reaction for 7 hours to obtain a uniform liquid product;
and S4, cooling the uniform liquid product to room temperature, filtering to remove precipitated solids, performing rotary evaporation on the residual liquid, and removing water to obtain a paste product, namely the novel corrosion inhibitor.
A preparation method of a low-corrosivity endoscope disinfectant comprises the following steps:
s1, mixing 200g of deionized water, 300g of novel corrosion inhibitor, 200g of glycerol solvent and 1g of BTA aid at the temperature of 35 ℃, and obtaining a first premixed solution after dissolution;
s2, mixing 200g of deionized water with 10g of AO-455 auxiliary surfactant, 1g of LF221 auxiliary surfactant, 10g of HEDP chelating agent and 15g of potassium hydroxide pH regulator, and uniformly mixing to obtain a second premixed solution;
and S3, mixing the first premixed liquid, the second premixed liquid and 63g of deionized water to obtain the low-corrosivity endoscope disinfectant.
The first and second examples, together with the commercial disinfectants, were evaluated for their disinfecting effect and their corrosiveness to metals, and the results are shown in the following table,
table 1 is an evaluation of the corrosiveness of metals according to the sterilization specifications,
table 2 shows the killing effect of Staphylococcus aureus according to the disinfection specifications
Table 3 shows the results of the sterilization simulation in-situ test on the medical instruments in example 1
Note: negative control sterile growth; the denominator is the number of test samples, and the numerator is the number of positive samples;
table 4 example 2 results of simulated field tests for sterilization of medical devices
The above description is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, several modifications and variations can be made without departing from the technical principle of the present invention, and these modifications and variations should also be regarded as the protection scope of the present invention.
Claims (10)
1. A low-corrosiveness endoscope disinfectant is characterized in that: the disinfectant comprises a liquid A and a liquid B, wherein the liquid A is prepared from the following raw materials in percentage by weight: 0.1 to 30 percent of novel corrosion inhibitor, 0.1 to 10 percent of auxiliary surfactant, 0.01 to 5 percent of chelating agent, 1 to 50 percent of solvent, 0.1 to 20 percent of pH regulator, 0.1 to 20 percent of auxiliary agent and the balance of deionized water, wherein the novel corrosion inhibitor is a reaction product of blocked polyether and o-phenylenediamine derivative; the solution B is a peroxyacetic acid solution with the concentration of 5 to 35wt%.
2. The disinfectant for low corrosiveness endoscope according to claim 1, wherein: the molecular structural formula of the end-capped polyether is R 1 -（OC 3 H 6 ） x （OC 2 H 4 ） y -OR 2 ，R 1 Comprising C 3 ~C 18 The number of X is 1 to 6, the number of Y is 1 to 9 2 Comprising C 2 O 3 H or C 4 H 5 O 3 。
3. The disinfectant for low corrosiveness endoscope according to claim 1, wherein: the molecular structural formula of the o-phenylenediamine derivative is Ar- (NH) 2 ) 2 And Ar is an aromatic compound.
4. The disinfectant for low corrosiveness endoscope according to claim 1, wherein: the molar ratio of the end-capped polyether to the o-phenylenediamine derivative is 1 to 3.
5. The disinfectant for low corrosiveness endoscope according to claim 1, wherein: the co-surfactant comprises at least an amine oxide and an anionic or nonionic surfactant;
amine oxides include lauryl dimethyl amine oxide, myristyl dimethyl amine oxide, dimethyl coco amine oxide, cocamidopropyl dimethyl amine oxide, tallowamidopropyl dimethyl amine oxide; the anionic or nonionic surfactant comprises alkyl sulfate, alkyl phosphate, fatty alcohol polyoxyethylene ether carboxylate, alkenyl sulfonate, succinate sulfonate, alkyl glyceryl ether sulfate, lauryl alcohol sulfonate, sodium lauryl sulfate, alkylbenzene sulfonate, fatty alcohol polyoxyethylene ether, fatty acid methyl ester ethoxylate and isomeric alcohol polyoxyethylene ether.
6. The disinfectant for low corrosiveness endoscope according to claim 1, wherein: the chelating agent comprises one or more of hydroxyethylidene diphosphonic acid, ethylene diamine tetraacetic acid and sodium salt thereof, diethylenetriamine pentamethylene phosphonic acid, ethylene diamine tetramethylene phosphonic acid sodium, phosphates, silicates, sodium glucoheptonate, tetrasodium glutamate diacetate, trisodium methylglycinediacetate, citric acid and citrate, maleic acid, polyacrylic acid and sodium salt.
7. The disinfectant for low corrosiveness endoscope according to claim 1, wherein: the auxiliary agent comprises one or more of benzotriazole, sodium molybdate, sulfonated lignin, polyethylene, POCA, polyaspartic acid, chromate, molybdate, tungstate, vanadate, nitrite, borate, phosphate and phosphorus-containing organic compounds.
8. The disinfectant for low corrosiveness endoscope according to claim 1, wherein: the solvent comprises one or more of glycerol, propylene glycol, ethanol, isopropanol, diethylene glycol methyl ether, triethylene glycol methyl ether, diethylene glycol ethyl ether, triethylene glycol ethyl ether, ethylene glycol propyl ether, ethylene glycol butyl ether, diethylene glycol butyl ether, triethylene glycol butyl ether, ethylene glycol hexyl ether, diethylene glycol hexyl ether, ethylene glycol butyl ether acetate, diethylene glycol butyl ether acetate, ethylene glycol phenyl ether, propylene glycol methyl ether, dipropylene glycol methyl ether, tripropylene glycol methyl ether, propylene glycol propyl ether, dipropylene glycol propyl ether, propylene glycol butyl ether, dipropylene glycol butyl ether, tripropylene glycol butyl ether, propylene glycol methyl ether acetate, dipropylene glycol methyl ether acetate, propylene glycol diacetate, propylene glycol phenyl ether, and dipropylene glycol dimethyl ether.
9. The disinfectant for low corrosiveness endoscope according to claim 1, wherein: the pH regulator comprises one or more of sodium hydroxide, potassium hydroxide, carbonate, bicarbonate, boric acid, borax, potassium dihydrogen phosphate, disodium hydrogen phosphate, phosphoric acid and citric acid.
10. A method for preparing a disinfectant for a low corrosiveness endoscope according to any of claims 1-9, comprising:
mixing deionized water with the novel corrosion inhibitor, the solvent and the auxiliary agent at the temperature of 30-40 ℃, and obtaining a first premixed solution after dissolution;
mixing deionized water with an auxiliary surfactant, a pH regulator, a chelating agent and a corrosion inhibitor, and uniformly mixing to obtain a second premixed solution;
and mixing the first premixed solution, the second premixed solution and deionized water to obtain the low-corrosivity endoscope disinfectant.
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