CN114958490B - Cleaning agent for removing sputum and preparation method thereof - Google Patents
Cleaning agent for removing sputum and preparation method thereof Download PDFInfo
- Publication number
- CN114958490B CN114958490B CN202210735545.1A CN202210735545A CN114958490B CN 114958490 B CN114958490 B CN 114958490B CN 202210735545 A CN202210735545 A CN 202210735545A CN 114958490 B CN114958490 B CN 114958490B
- Authority
- CN
- China
- Prior art keywords
- cleaning agent
- sputum
- stirring
- cleaning
- removing sputum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000012459 cleaning agent Substances 0.000 title claims abstract description 82
- 206010036790 Productive cough Diseases 0.000 title claims abstract description 66
- 208000024794 sputum Diseases 0.000 title claims abstract description 66
- 210000003802 sputum Anatomy 0.000 title claims abstract description 56
- 238000002360 preparation method Methods 0.000 title abstract description 15
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims abstract description 22
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- 238000005260 corrosion Methods 0.000 claims abstract description 20
- 239000004094 surface-active agent Substances 0.000 claims abstract description 19
- 230000007797 corrosion Effects 0.000 claims abstract description 18
- 108091005658 Basic proteases Proteins 0.000 claims abstract description 15
- 239000002904 solvent Substances 0.000 claims abstract description 14
- 239000003112 inhibitor Substances 0.000 claims abstract description 13
- 108010028921 Lipopeptides Proteins 0.000 claims abstract description 11
- 229960004543 anhydrous citric acid Drugs 0.000 claims abstract description 11
- 239000012153 distilled water Substances 0.000 claims abstract description 11
- 238000003756 stirring Methods 0.000 claims description 31
- 238000000034 method Methods 0.000 claims description 14
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 9
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- 239000000126 substance Substances 0.000 claims description 8
- SEHJHHHUIGULEI-UHFFFAOYSA-N 2-hydroxyethylphosphonic acid Chemical compound OCCP(O)(O)=O SEHJHHHUIGULEI-UHFFFAOYSA-N 0.000 claims description 5
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims description 5
- 239000000022 bacteriostatic agent Substances 0.000 claims description 5
- DHNRXBZYEKSXIM-UHFFFAOYSA-N chloromethylisothiazolinone Chemical compound CN1SC(Cl)=CC1=O DHNRXBZYEKSXIM-UHFFFAOYSA-N 0.000 claims description 4
- OUNZARDETXBPIX-UHFFFAOYSA-N 2-(2-dodecoxyethoxy)acetic acid Chemical compound CCCCCCCCCCCCOCCOCC(O)=O OUNZARDETXBPIX-UHFFFAOYSA-N 0.000 claims description 3
- 239000002202 Polyethylene glycol Substances 0.000 claims description 3
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 claims description 3
- 229920001223 polyethylene glycol Polymers 0.000 claims description 3
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 claims description 3
- AEQDJSLRWYMAQI-UHFFFAOYSA-N 2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline Chemical compound C1CN2CC(C(=C(OC)C=C3)OC)=C3CC2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-UHFFFAOYSA-N 0.000 claims description 2
- HJVAFZMYQQSPHF-UHFFFAOYSA-N 2-[bis(2-hydroxyethyl)amino]ethanol;boric acid Chemical compound OB(O)O.OCCN(CCO)CCO HJVAFZMYQQSPHF-UHFFFAOYSA-N 0.000 claims description 2
- ZSPTYLOMNJNZNG-UHFFFAOYSA-N 3-Buten-1-ol Chemical group OCCC=C ZSPTYLOMNJNZNG-UHFFFAOYSA-N 0.000 claims description 2
- QRUDEWIWKLJBPS-UHFFFAOYSA-N benzotriazole Chemical compound C1=CC=C2N[N][N]C2=C1 QRUDEWIWKLJBPS-UHFFFAOYSA-N 0.000 claims description 2
- 239000012964 benzotriazole Substances 0.000 claims description 2
- BEGLCMHJXHIJLR-UHFFFAOYSA-N methylisothiazolinone Chemical compound CN1SC=CC1=O BEGLCMHJXHIJLR-UHFFFAOYSA-N 0.000 claims description 2
- 239000000176 sodium gluconate Substances 0.000 claims description 2
- 229940005574 sodium gluconate Drugs 0.000 claims description 2
- 235000012207 sodium gluconate Nutrition 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 18
- 238000004140 cleaning Methods 0.000 abstract description 16
- KAFMEYHUAVHJGX-UHFFFAOYSA-N P(=O)(O)OP(=O)O.OCCC=C Chemical compound P(=O)(O)OP(=O)O.OCCC=C KAFMEYHUAVHJGX-UHFFFAOYSA-N 0.000 abstract 1
- 239000003344 environmental pollutant Substances 0.000 description 20
- 231100000719 pollutant Toxicity 0.000 description 20
- 230000000052 comparative effect Effects 0.000 description 18
- 239000000243 solution Substances 0.000 description 18
- 239000006260 foam Substances 0.000 description 17
- 238000012360 testing method Methods 0.000 description 15
- 230000001680 brushing effect Effects 0.000 description 12
- 239000008213 purified water Substances 0.000 description 10
- 230000008569 process Effects 0.000 description 9
- 238000002791 soaking Methods 0.000 description 9
- 239000000047 product Substances 0.000 description 8
- 238000010790 dilution Methods 0.000 description 6
- 239000012895 dilution Substances 0.000 description 6
- 238000003113 dilution method Methods 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 239000011521 glass Substances 0.000 description 6
- 229940051841 polyoxyethylene ether Drugs 0.000 description 6
- 229920000056 polyoxyethylene ether Polymers 0.000 description 6
- 230000007306 turnover Effects 0.000 description 6
- 238000005406 washing Methods 0.000 description 6
- 102000004190 Enzymes Human genes 0.000 description 5
- 108090000790 Enzymes Proteins 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 238000000354 decomposition reaction Methods 0.000 description 4
- 229910052751 metal Inorganic materials 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- 238000013112 stability test Methods 0.000 description 4
- 229910001220 stainless steel Inorganic materials 0.000 description 4
- 239000010935 stainless steel Substances 0.000 description 4
- 101800000263 Acidic protein Proteins 0.000 description 3
- 239000004368 Modified starch Substances 0.000 description 3
- 229920000881 Modified starch Polymers 0.000 description 3
- 238000004364 calculation method Methods 0.000 description 3
- 239000003599 detergent Substances 0.000 description 3
- 238000005065 mining Methods 0.000 description 3
- 235000019426 modified starch Nutrition 0.000 description 3
- 238000012797 qualification Methods 0.000 description 3
- KBPLFHHGFOOTCA-UHFFFAOYSA-N 1-Octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 description 2
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 2
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 108091005804 Peptidases Proteins 0.000 description 2
- 239000004365 Protease Substances 0.000 description 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000003876 biosurfactant Substances 0.000 description 2
- 229910001424 calcium ion Inorganic materials 0.000 description 2
- 235000019864 coconut oil Nutrition 0.000 description 2
- 239000003240 coconut oil Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000005202 decontamination Methods 0.000 description 2
- 230000003588 decontaminative effect Effects 0.000 description 2
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 2
- 238000011010 flushing procedure Methods 0.000 description 2
- 230000008595 infiltration Effects 0.000 description 2
- 238000001764 infiltration Methods 0.000 description 2
- 210000004969 inflammatory cell Anatomy 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000009972 noncorrosive effect Effects 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 230000000241 respiratory effect Effects 0.000 description 2
- 239000002455 scale inhibitor Substances 0.000 description 2
- 239000000344 soap Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 238000009736 wetting Methods 0.000 description 2
- WKPFIJAMMDLXDI-UHFFFAOYSA-N 1,2-thiazolidin-4-one Chemical compound O=C1CNSC1 WKPFIJAMMDLXDI-UHFFFAOYSA-N 0.000 description 1
- 239000010963 304 stainless steel Substances 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 229910000589 SAE 304 stainless steel Inorganic materials 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000013522 chelant Substances 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 230000001338 necrotic effect Effects 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 229940048842 sodium xylenesulfonate Drugs 0.000 description 1
- QUCDWLYKDRVKMI-UHFFFAOYSA-M sodium;3,4-dimethylbenzenesulfonate Chemical compound [Na+].CC1=CC=C(S([O-])(=O)=O)C=C1C QUCDWLYKDRVKMI-UHFFFAOYSA-M 0.000 description 1
- 239000008234 soft water Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/02—Anionic compounds
- C11D1/12—Sulfonic acids or sulfuric acid esters; Salts thereof
- C11D1/22—Sulfonic acids or sulfuric acid esters; Salts thereof derived from aromatic compounds
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/02—Anionic compounds
- C11D1/04—Carboxylic acids or salts thereof
- C11D1/06—Ether- or thioether carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/02—Anionic compounds
- C11D1/37—Mixtures of compounds all of which are anionic
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D10/00—Compositions of detergents, not provided for by one single preceding group
- C11D10/04—Compositions of detergents, not provided for by one single preceding group based on mixtures of surface-active non-soap compounds and soap
- C11D10/042—Compositions of detergents, not provided for by one single preceding group based on mixtures of surface-active non-soap compounds and soap based on anionic surface-active compounds and soap
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/166—Organic compounds containing borium
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2003—Alcohols; Phenols
- C11D3/2041—Dihydric alcohols
- C11D3/2044—Dihydric alcohols linear
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2003—Alcohols; Phenols
- C11D3/2065—Polyhydric alcohols
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2075—Carboxylic acids-salts thereof
- C11D3/2086—Hydroxy carboxylic acids-salts thereof
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/26—Organic compounds containing nitrogen
- C11D3/28—Heterocyclic compounds containing nitrogen in the ring
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/26—Organic compounds containing nitrogen
- C11D3/30—Amines; Substituted amines ; Quaternized amines
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/26—Organic compounds containing nitrogen
- C11D3/32—Amides; Substituted amides
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/34—Organic compounds containing sulfur
- C11D3/349—Organic compounds containing sulfur additionally containing nitrogen atoms, e.g. nitro, nitroso, amino, imino, nitrilo, nitrile groups containing compounds or their derivatives or thio urea
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/36—Organic compounds containing phosphorus
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/37—Polymers
- C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C11D3/3707—Polyethers, e.g. polyalkyleneoxides
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38618—Protease or amylase in liquid compositions only
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/43—Solvents
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Emergency Medicine (AREA)
- Detergent Compositions (AREA)
Abstract
The invention discloses a cleaning agent for removing sputum and a preparation method thereof, and belongs to the field of medical cleaning agents. The cleaning agent comprises the following components: 1-3% of lipopeptide, 5-6% of ethanolamine, 2-3% of anhydrous citric acid, 2-3% of hydroxyethylethylene diphosphonic acid, 8-10% of surfactant, 0.2-0.3% of corrosion inhibitor, 10-15% of solvent, 5-8% of alkaline protease Everis Duo L, 0.1% of bacteriostat and the balance of distilled water. The cleaning agent has stable performance, obvious effect, good stability, safety, mildness and no corrosion, and can be used for manual cleaning of medical tracheal tubes.
Description
Technical Field
The invention relates to the technical field of cleaning agents, in particular to a cleaning agent for removing sputum and a preparation method thereof.
Background
Sputum is a fluid produced by the stimulation of the respiratory tract, also known as sputum. The components include mucus, foreign matter, pathogenic microorganism, various inflammatory cells, necrotic exfoliated mucosal epithelial cells, etc. The increased viscosity of sputum is related to the increased content of acidic proteins in the sputum, and the high content of calcium ions in the sputum can increase the viscosity. In the case of respiratory tract infection, DNA generated by the destruction of a large number of inflammatory cells significantly increases the viscosity of sputum, so-called thick sputum is formed, which is difficult to be discharged, and is extremely difficult to clean after adhering to other objects.
The tracheal cannula is a secondary respiratory passage of a patient with tracheotomy operation, and can provide respiratory assurance for the patient with laryngeal operation. The tracheal cannula has a complex structure, and can cause a large amount of attached sputum in the tracheal cannula, thereby increasing the cleaning difficulty. The tracheal cannula is difficult to clean in the manual treatment process due to the complexity of the tracheal cannula, and the conventional multienzyme cleaning agent or alkaline cleaning agent on the market has almost no softening and removing effects on sputum. The medical multienzyme cleaning agent and the preparation method thereof (CN 201210534832) are disclosed in a plurality of patents related to the medical multienzyme cleaning agent or alkaline cleaning agent, wherein the medical multienzyme cleaning agent comprises the following components in parts by weight: the polyoxyethylene ether of the dodecanol polyoxyethylene ether has a polymerization unit number of 20, and the polyoxyethylene ether of the octanol polyoxyethylene ether has a polymerization unit number of 5. The method provides a preparation method of the medical multienzyme cleaning agent, has wide application range, does not specially study the removal of tracheal cannula sputum, and has an unobvious removal effect. A medical instrument multienzyme cleaning agent and a preparation method thereof (CN 201610694650) disclose a medical instrument multienzyme cleaning agent and a preparation method thereof, and the novel dispersing scale inhibitor is used as a raw material, so that the novel dispersing scale inhibitor has high-efficiency scale inhibition performance, the functions of increasing the cleaning performance and dispersing dirt are brought, and meanwhile, the substance can chelate calcium ions on bacterial membranes, so that a preservative can more easily permeate into bacteria, and a better anti-corrosion effect is achieved. The prepared multienzyme cleaning agent has the advantages of high efficiency in scale inhibition, high dispersion, low residue, low foam, easiness in rinsing and the like. Belongs to the field of medical cleaning, and also has the research of lacking the effect of removing the specific pollutant of sputum, and has poor removing effect.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides the cleaning agent specially used for removing the sputum of the tracheal cannula, which has the advantages of remarkable effect, good stability, safety, mildness, no corrosion, low foam and easy rinsing, and provides an optimal scheme for centralized treatment of the tracheal cannula in a supply room.
In one aspect, the invention provides a cleaning agent for removing sputum, which comprises the following components in percentage by weight: 1-3% of lipopeptide, 5-6% of ethanolamine, 2-3% of anhydrous citric acid, 2-3% of hydroxyethylethylene binary phosphonic acid, 8-10% of surfactant, 0.2-0.3% of corrosion inhibitor, 10-15% of solvent, 5-8% of alkaline protease Norwestin Everis Duo L, 0.1% of bacteriostat and the balance of distilled water.
Preferably, the surfactant is one or more of crude coconut oil soap, sodium dodecyl benzene sulfonate, sodium laureth-6 carboxylate and sodium xylene sulfonate.
Preferably, the corrosion inhibitor is one or more of benzotriazole, sodium gluconate and triethanolamine borate.
Preferably, the solvent is one or more of propylene glycol, glycerol and polyethylene glycol.
Preferably, the bacteriostatic agent is one or two of 5-chloro-2-methyl-3 (2H) -isothiazolone and 2-methyl-3 (2H) -isothiazolone.
On the other hand, the invention also provides a preparation method of the cleaning agent for removing sputum, which comprises the following steps:
s1: dissolving anhydrous citric acid in distilled water;
s2: sequentially adding lipopeptide, ethanolamine and hydroxyethylphosphonic acid into the solution obtained in the step S1, stirring until the solution is colorless and transparent and has no insoluble substances, and then adding a bacteriostat;
S3: sequentially adding a solvent, a corrosion inhibitor and a surfactant into the solution obtained in the step S2, and stirring;
S4: and (3) carrying out a slight exothermic reaction in the stirring process, and adding alkaline protease after the temperature of the solution in the step (S3) is reduced to room temperature, and stirring to obtain the product.
Preferably, in step S2, the stirring time is 1-2 hours.
Preferably, in step S3, the stirring time is 30-60min.
Preferably, in step S4, the stirring time is 1-2 hours.
When in use, the cleaning agent is diluted with soft water or purified water according to the proportion of 1:30-50, and the sputum is softened and removed by manual soaking, so that the sputum in the tracheal cannula can be effectively removed.
Compared with the prior art, the invention has the following beneficial effects:
According to the cleaning agent for removing sputum, which is prepared by the invention, due to the addition of the specific biosurfactant lipopeptid and other surfactants, the interfacial tension between sputum pollutants and aqueous solution can be reduced in the use process through the compound synergy, so that the rapid stripping of the sputum pollutants is facilitated. Meanwhile, the specific solvent ensures the rapid infiltration and wetting of the surfactant, and accelerates the softening, decomposition and stripping of sputum pollutants. The specific protease effectively decomposes acidic proteins in the sputum so as to reduce the viscosity of the sputum and facilitate the decomposition and decontamination of pollutants. The invention is characterized in that surfactant and biological enzyme are compounded aiming at the specific pollutant of sputum, and the specific formula ensures that the cleaning agent can rapidly soften and decompose the sputum in the soaking process of the dried sputum pollutant, and the tracheal cannula for intensively treating a large amount of pollution can be realized by simple flushing after the effect of the cleaning agent.
Detailed Description
In order to better understand the technical solutions of the present invention, the following description will clearly and completely describe the technical solutions of the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the present invention without making any inventive effort, shall fall within the scope of the present invention.
Example 1
The embodiment provides a cleaning agent for removing sputum, which comprises the following components in percentage by weight: 1% of lipopeptide, 5% of ethanolamine, 2% of anhydrous citric acid, 2% of hydroxyethyl binary phosphonic acid, 8% of crude coconut oil soap, 0.2% of corrosion inhibitor, 10% of propylene glycol, 5% of alkaline protease, 0.1% of 5-chloro-2-methyl-3 (2H) -isothiazolone and the balance of distilled water.
The preparation method of the cleaning agent comprises the following steps:
s1: dissolving anhydrous citric acid in distilled water;
S2: sequentially adding lipopeptide, ethanolamine and hydroxyethylphosphonic acid into the solution obtained in the step S1, stirring for 1h until the solution is colorless and transparent and has no insoluble substances, and then adding a bacteriostatic agent;
S3: sequentially adding a solvent, a corrosion inhibitor and a surfactant into the solution obtained in the step S2, and stirring for 30min;
S4: and (3) carrying out a slight exothermic reaction in the stirring process, and adding alkaline protease after the temperature of the solution in the step (S3) is reduced to room temperature, and stirring for 1h to obtain the modified starch.
Stability test: meets the requirement of the validity period stability test in the medical cleaning agent sanitary requirement.
The test method comprises the following steps: the test was carried out by aging for the shelf life stability at 37℃for 90 days. Checking whether the external hanging of the cleaning agent is changed.
Test results: after the product is stored for 90 days at 37 ℃, the appearance of the product is unchanged and still light yellow.
Corrosiveness test: the test method is carried out according to the measurement of the corrosiveness of the cleaning agent for traditional Chinese medicine in medical cleaning agent sanitary requirements. And (3) immersing the 304 stainless steel sheet in the stock solution of the sputum-removing cleaning agent, immersing for 72 hours at 40 ℃, and weighing the stainless steel sheet before and after immersing.
Calculation formula of metal corrosion rate (R):
r-corrosion rate in millimeters per year (mm/a);
m-weight of sheet metal before test in grams (g);
m t -weight of the metal sheet after the test in grams (g);
m k -the weight loss value of the sample wafer of the corrosion product removed by chemical treatment, the unit is gram (g), if the chemical removal treatment is not carried out in the test, the value of m k is deleted in the formula during calculation;
S-the total surface area of the sheet metal in square centimeters (cm 2);
t-test time in hours (h):
d-density of metallic material in kilograms per cubic meter (kg/m 3).
The test calculation shows that R=0.0046 and R <0.0100 shows that the sputum-removing cleaning agent is basically free from corrosion to stainless steel.
Foam amount test: the foam quantity value of the sputum-removed cleaning agent is 0, and the foam is hardly tested by the SITA foam quantity tester, so that the sputum-removed cleaning agent belongs to typical low-foam cleaning agents.
Practical use case 1: 500ml of the cleaning agent prepared in example 1 was placed in a 20L turnover box, and 15L of purified water was added for dilution and uniform stirring, and labeled as experiment group A; the purchased quick and efficient multienzyme cleaning agent of medical equipment (Shanghai) limited company manufactured by Minnesota mining in the United states is marked as a control group B according to the same dilution method; the specific alkaline enzyme-containing detergent purchased from German Inlet Wei Gebo was labeled as control C according to the same dilution method. Thirty night untreated tracheal tubes were randomly assigned to three groups in the clinical laboratory and immersed in experimental group a, control group B, C, respectively. After soaking for 10min, washing and brushing with a soft brush for 5s, brushing for 1min, and observing with a magnifying glass with a light source, wherein no visible pollutant is visually detected as the cleaning is qualified. The yield comparison data is as follows:
Experimental comparison shows that the conventional multienzyme cleaning agent has almost no softening and decomposing effects on the sputum of the sleeve, and the cleaning agent for removing the sputum prepared by the embodiment has remarkable effect and can efficiently assist in basic treatment of the sputum of the sleeve.
Example 2
The embodiment provides a cleaning agent for removing sputum, which comprises the following components in percentage by weight: 3% of lipopeptide, 4% of ethanolamine, 3% of anhydrous citric acid, 3% of hydroxyethyl binary phosphonic acid, 9% of sodium dodecyl benzene sulfonate, 0.2% of corrosion inhibitor, 13% of glycerol, 8% of alkaline protease, 0.1% of 2-methyl-3 (2H) -isothiazolinone and the balance of distilled water.
The preparation method of the cleaning agent comprises the following steps:
s1: dissolving anhydrous citric acid in distilled water;
S2: sequentially adding lipopeptide, ethanolamine and hydroxyethylphosphonic acid into the solution obtained in the step S1, stirring for 1h until the solution is colorless and transparent and has no insoluble substances, and then adding a bacteriostatic agent;
S3: sequentially adding a solvent, a corrosion inhibitor and a surfactant into the solution obtained in the step S2, and stirring for 30min;
S4: and (3) carrying out a slight exothermic reaction in the stirring process, and adding alkaline protease after the temperature of the solution in the step (S3) is reduced to room temperature, and stirring for 1h to obtain the modified starch.
Stability test: after the product is stored for 90 days at 37 ℃, the appearance of the product is unchanged and still light yellow.
Corrosiveness test:
R=0.0053, R <0.0100, indicating that the sputum-removing cleaning agent is substantially non-corrosive to stainless steel.
Foam amount test: the foam quantity value of the sputum-removed cleaning agent is 0, and the foam is hardly tested by the SITA foam quantity tester, so that the sputum-removed cleaning agent belongs to typical low-foam cleaning agents.
Practical use case 2: 500ml of the cleaning agent prepared in example 2 was placed in a 20L turnover box, and 15L of purified water was added for dilution and uniform stirring, and labeled as experiment group A; the purchased quick and efficient multienzyme cleaning agent of medical equipment (Shanghai) limited company manufactured by Minnesota mining in the United states is marked as a control group B according to the same dilution method; the specific alkaline enzyme-containing detergent purchased from German Inlet Wei Gebo was labeled as control C according to the same dilution method. Thirty night untreated tracheal tubes were randomly assigned to three groups in the clinical laboratory and immersed in experimental group a, control group B, C, respectively. After soaking for 10min, washing and brushing with a soft brush for 5s, brushing for 1min, and observing with a magnifying glass with a light source, wherein no visible pollutant is visually detected as the cleaning is qualified. The yield comparison data is as follows:
Experimental comparison shows that the conventional multienzyme cleaning agent has almost no softening and decomposing effects on the sputum of the sleeve, and the cleaning agent for removing the sputum prepared by the embodiment has remarkable effect and can efficiently assist in basic treatment of the sputum of the sleeve.
Example 3
The embodiment provides a cleaning agent for removing sputum, which comprises the following components in percentage by weight: lipopeptide 2%, ethanolamine 6%, anhydrous citric acid 3%, hydroxyethylbinary phosphonic acid 2%, sodium laureth-6 carboxylate 10%, corrosion inhibitor 0.3%, polyethylene glycol 15%, alkaline protease 7%, 5-chloro-2-methyl-3 (2H) -isothiazolone 0.1% and distilled water in balance.
The preparation method of the cleaning agent comprises the following steps:
s1: dissolving anhydrous citric acid in distilled water;
S2: sequentially adding lipopeptide, ethanolamine and hydroxyethylphosphonic acid into the solution obtained in the step S1, stirring for 1h until the solution is colorless and transparent and has no insoluble substances, and then adding a bacteriostatic agent;
S3: sequentially adding a solvent, a corrosion inhibitor and a surfactant into the solution obtained in the step S2, and stirring for 30min;
S4: and (3) carrying out a slight exothermic reaction in the stirring process, and adding alkaline protease after the temperature of the solution in the step (S3) is reduced to room temperature, and stirring for 1h to obtain the modified starch.
Stability test: after the product is stored for 90 days at 37 ℃, the appearance of the product is unchanged and still light yellow.
Corrosiveness test: r=0.0059, R <0.0100, indicating that the sputum-removing cleaning agent is substantially non-corrosive to stainless steel.
Foam amount test: the foam quantity value of the sputum-removed cleaning agent is 0, and the foam is hardly tested by the SITA foam quantity tester, so that the sputum-removed cleaning agent belongs to typical low-foam cleaning agents.
Practical use case 3: 500ml of the cleaning agent prepared in example 3 was sampled and placed in a 20L turnover box, and 15L of purified water was added for dilution and uniform stirring, and labeled as experiment group A; the purchased quick and efficient multienzyme cleaning agent of medical equipment (Shanghai) limited company manufactured by Minnesota mining in the United states is marked as a control group B according to the same dilution method; the specific alkaline enzyme-containing detergent purchased from German Inlet Wei Gebo was labeled as control C according to the same dilution method. Thirty night untreated tracheal tubes were randomly assigned to three groups in the clinical laboratory and immersed in experimental group a, control group B, C, respectively. After soaking for 10min, washing and brushing with a soft brush for 5s, brushing for 1min, and observing with a magnifying glass with a light source, wherein no visible pollutant is visually detected as the cleaning is qualified. The yield comparison data is as follows:
experimental comparison shows that the conventional multienzyme cleaning agent has almost no softening and decomposing effects on the sputum of the sleeve, and the cleaning agent for removing the sputum prepared in the embodiment has remarkable effect, and can efficiently assist in basic treatment of the sputum of the sleeve.
Comparative example 1
Comparative example 1 differs from example 1 in that: the surfactant is replaced by sodium polyoxyethylene ether sulfate.
Placing 500ml of the cleaning agent prepared in the comparative example 1 in a 20L turnover box, adding 15L of purified water for dilution and uniformly stirring, and marking as a control group D; 500ml of the cleaning agent prepared in example 1 was placed in a 20L circulation box, diluted with 15L of purified water and stirred uniformly, and labeled as Experimental group A. Twenty night untreated tracheal tubes were randomly distributed into two groups in the clinical laboratory and immersed in experimental group a and control group D, respectively. After soaking for 10min, washing and brushing with a soft brush for 5s, brushing for 1min, and observing with a magnifying glass with a light source, wherein no visible pollutant is visually detected as the cleaning is qualified. The yield comparison data is as follows:
The experimental comparison shows that: the only difference between comparative example 1 and example 1 is that the types of surfactants used are different, and comparative example 1 uses a high foaming anionic surfactant such as sodium polyoxyethylene ether sulfate, which is a common surfactant. The cleaning agent prepared according to the same preparation method is not difficult to find in a comparative experiment of a cleaning effect test that the cleaning qualification rate of the cleaning agent prepared in the embodiment 1 of the invention is obviously higher than that of the control group D.
Comparative example 2
Comparative example 2 differs from example 2 in that: the solvent of example 1 was replaced with ethanol.
Placing 500ml of the cleaning agent prepared in comparative example 2 in a 20L turnover box, adding 15L of purified water for dilution, uniformly stirring, and marking as a control group D; 500ml of the cleaning agent prepared in example 2 was placed in a 20L circulation box, diluted with 15L of purified water and stirred uniformly, and labeled as Experimental group A. Twenty night untreated tracheal tubes were randomly distributed into two groups in the clinical laboratory and immersed in experimental group a and control group D, respectively. After soaking for 10min, washing and brushing with a soft brush for 5s, brushing for 1min, and observing with a magnifying glass with a light source, wherein no visible pollutant is visually detected as the cleaning is qualified. The yield comparison data is as follows:
The experimental comparison shows that: the only difference between comparative example 2 and example 2 is the different type of solvents used, and comparative example 2 uses common ethanol. The cleaning agent prepared according to the same preparation method is not difficult to find in the comparative experiment of the cleaning effect test that the cleaning qualification rate of the cleaning agent prepared in the embodiment 2 of the invention is obviously higher than that of the control group D.
Comparative example 3
Comparative example 3 differs from example 3 in that: the alkaline protease of example 3 was replaced with an alkaline protease of the biological engineering Co.Ltd. Nanning Pang Bo.
Placing 500ml of the cleaning agent prepared in the comparative example 3 in a 20L turnover box, adding 15L of purified water for dilution and uniformly stirring, and marking as a control group D; 500ml of the cleaning agent prepared in example 3 was placed in a 20L circulation box, diluted with 15L of purified water and stirred uniformly, and labeled as Experimental group A. Twenty night untreated tracheal tubes were randomly distributed into two groups in the clinical laboratory and immersed in experimental group a and control group D, respectively. After soaking for 10min, washing and brushing with a soft brush for 5s, brushing for 1min, and observing with a magnifying glass with a light source, wherein no visible pollutant is visually detected as the cleaning is qualified. The yield comparison data is as follows:
the experimental comparison shows that: the only difference between comparative example 3 and example 3 is that the alkaline proteases used are different in kind, and common alkaline proteases are used in comparative example 3. The cleaning agent prepared according to the same preparation method is not difficult to find in the comparative experiment of the cleaning effect test that the cleaning qualification rate of the cleaning agent prepared in the embodiment 3 of the invention is obviously higher than that of the control group D.
Mechanism of action of the cleaning agent: according to the cleaning agent for removing sputum, which is prepared by the invention, due to the addition of the specific biosurfactant lipopeptid and other surfactants, the interfacial tension between sputum pollutants and aqueous solution can be reduced in the use process through the compound synergy, so that the rapid stripping of the sputum pollutants is facilitated. Meanwhile, the specific solvent ensures the rapid infiltration and wetting of the surfactant, and accelerates the softening, decomposition and stripping of sputum pollutants; the specific protease effectively decomposes acidic proteins in the sputum so as to reduce the viscosity of the sputum and facilitate the decomposition and decontamination of pollutants. The invention relates to a tracheal cannula which is prepared by compounding a surfactant and biological enzyme aiming at specific pollutants such as sputum, wherein the specific formula enables a cleaning agent to rapidly soften and decompose the sputum in the soaking process of the dried sputum pollutants, and the tracheal cannula can be used for intensively treating a large amount of pollutants by simply flushing after the effect of the cleaning agent.
Although the present invention has been described in detail by way of preferred embodiments, the present invention is not limited thereto. Various equivalent modifications and substitutions may be made in the embodiments of the present invention by those skilled in the art without departing from the spirit and scope of the present invention, and it is intended that all such modifications and substitutions be within the scope of the present invention/be within the scope of the present invention as defined by the appended claims. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims (7)
1. The cleaning agent for removing sputum is characterized by comprising the following components in percentage by weight: 1-3% of lipopeptide, 5-6% of ethanolamine, 2-3% of anhydrous citric acid, 2-3% of hydroxyethylethylene binary phosphonic acid, 8-10% of surfactant, 0.2-0.3% of corrosion inhibitor, 10-15% of solvent, 5-8% of alkaline protease Everis Duo L, 0.1% of bacteriostat and the balance of distilled water; the surfactant is one or two of sodium dodecyl benzene sulfonate and sodium laureth-6 carboxylate; the solvent is one or more of propylene glycol, glycerol and polyethylene glycol.
2. The cleaning agent for removing sputum according to claim 1, wherein the corrosion inhibitor is one or more of benzotriazole, sodium gluconate and triethanolamine borate.
3. The cleaning agent for removing sputum according to claim 1, wherein the bacteriostatic agent is one or two of 5-chloro-2-methyl-3 (2H) -isothiazolone and 2-methyl-3 (2H) -isothiazolone.
4. A method for preparing a cleaning agent for removing sputum according to any one of claims 1 to 3, comprising the steps of:
s1: dissolving anhydrous citric acid in distilled water;
s2: sequentially adding lipopeptide, ethanolamine and hydroxyethylphosphonic acid into the solution obtained in the step S1, stirring until the solution is colorless and transparent and has no insoluble substances, and then adding a bacteriostat;
S3: sequentially adding a solvent, a corrosion inhibitor and a surfactant into the solution obtained in the step S2, and stirring;
S4: and (3) after the temperature of the solution in the step (S3) is reduced to room temperature, adding alkaline protease, and stirring to obtain the product.
5. The method of claim 4, wherein the stirring time in step S2 is 1-2 hours.
6. The method of preparing a cleaning agent for removing sputum according to claim 4, wherein the stirring time is 30-60min in step S3.
7. The method of preparing a cleaning agent for removing sputum according to claim 4, wherein the stirring time is 1-2 hours in step S4.
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