JP2009132692A - Endoscope disinfectant - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an endoscope disinfectant which is one comprising an aqueous solution containing acetic acid, peracetic acid, and hydrogen peroxide and can be stably used for a long term and to provide a kit containing the endoscope disinfectant. <P>SOLUTION: Provided are an endoscope disinfectant comprising an aqueous solution containing acetic acid, peracetic acid, and hydrogen peroxide, wherein the mass ratio between the acetic acid content and the peracetic acid content is 1:1 to 3:1 (acetic acid mass:peracetic acid mass), and an endoscope disinfection kit comprising the endoscope disinfectant and an adjuvant including at least one member selected from the group consisting of a buffering agent, an anticorrosive, a pH modifier, a metal ion sequestering agent, a stabilizer, an anti-redeposition agent, and a surfactant. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to an endoscope disinfectant and an endoscope disinfection kit. More specifically, the present invention relates to an endoscope disinfectant comprising an aqueous solution containing acetic acid, peracetic acid, and hydrogen peroxide, and a kit containing the endoscope disinfectant.

Endoscopes are widely used for examination and treatment of the upper and lower digestive tract, respiratory organs, and body cavities of the human body. Endoscopes are cleaned and disinfected every time they are used to prevent infection among patients. In recent years, endoscope cleaning and disinfection is often performed by an automatic endoscope cleaning and disinfecting apparatus. Typically, after manual brushing cleaning in the endoscope channel, the endoscope is set in the endoscope cleaning and disinfecting device, automatically cleaning, rinsing, drug immersion disinfecting and rinsing, drying And is done sequentially.

Glutaral, orthophthalal, and peracetic acid are approved as high-level disinfectants as disinfectants used for cleaning and disinfecting endoscopes. Among these, the peracetic acid solution is said to be safer than the aldehyde system. Examples of disinfecting an endoscope with a peracetic acid disinfectant are disclosed in Patent Documents 1 and 2, for example.

These disinfectants are generally expensive and are recovered after disinfection and used repeatedly.
However, when a peracetic acid solution is used in an automatic endoscope cleaning / disinfecting apparatus, the stability over time is poor, and the effective peracetic acid concentration can be maintained at room temperature for about 10 days. Moreover, as a disinfectant, it is common to store in the state of a concentrated solution of an active ingredient from the viewpoint of stability, but peracetic acid is likely to decompose over time even in the state of the concentrated solution. For this reason, there is a problem that the concentration of peracetic acid in a practical solution that is diluted at a constant magnification and used for disinfection or sterilization varies depending on the elapsed time until the concentrated solution is used.
For this reason, a disinfectant whose peracetic acid concentration does not easily decrease over time has been desired.

Further, when peracetic acid is used at a high concentration, there is a problem that the members (metal and plastic parts) of the endoscope are deteriorated. On the other hand, if used at a low concentration, sufficient sterilizing ability cannot be obtained. In general, it is necessary to disinfect or sterilize an endoscope while maintaining the concentration of peracetic acid in the disinfectant solution in the range of about 0.2 to 0.4% by mass.

WO00 / 22931 JP 2001-70413 A

  An object of the present invention is an endoscope disinfectant composed of an aqueous solution containing acetic acid, peracetic acid and hydrogen peroxide, which can be used stably for a long period of time, and the endoscope disinfectant It is to provide a kit containing a drug.

As a result of intensive studies, the inventors of the present invention have found a content ratio of acetic acid and peracetic acid that can easily maintain the concentration of peracetic acid in an aqueous solution containing acetic acid, peracetic acid, and hydrogen peroxide. The present invention has been completed.
That is, the present invention provides the following.

(1) An endoscope disinfectant comprising an aqueous solution containing acetic acid, peracetic acid and hydrogen peroxide, wherein the mass ratio of acetic acid to peracetic acid is 1: 1 to 3: 1 (acetic acid mass: Endoscopic disinfectant with acetic acid mass).
(2) The endoscope disinfectant according to (1), wherein the concentration of peracetic acid is 7% by mass or more and 15% by mass or less.
(3) From the endoscope disinfectant according to (1) or (2), a buffer, a corrosion inhibitor, a pH adjuster, a sequestering agent, a stabilizer, a reattachment inhibitor, and a surfactant An endoscope disinfection kit comprising an additive containing at least one selected from the group consisting of:

(4) The kit according to (3), wherein the composition contains an organic phosphonic acid.
(5) The kit according to (3) or (4), wherein the composition contains a benzotriazole derivative.
(6) A high-level endoscope comprising a step of bringing a disinfectant containing the endoscope disinfectant according to (1) or (2) into contact with an endoscope in an automatic washing machine for 1 to 15 minutes. How to disinfect.
(7) The method according to (6), wherein the disinfecting solution brought into contact with the endoscope is discarded for each contact.

According to the present invention, there is provided an endoscope disinfectant comprising an aqueous solution containing acetic acid, peracetic acid and hydrogen peroxide, which can be used stably for a long period of time.

The present invention is described in detail below.
In the present specification, “to” is used to mean that the numerical values described before and after it are included as a lower limit value and an upper limit value.
The endoscope disinfectant of the present invention comprises an aqueous solution containing acetic acid, peracetic acid, and hydrogen peroxide. In this aqueous solution, acetic acid, peracetic acid, and hydrogen peroxide need only exist in an equilibrium state.

The mass ratio of acetic acid and peracetic acid in the endoscope disinfectant of the present invention is 1: 1 to 3: 1 (acetic acid mass: peracetic acid mass). That is, it is 1 or more and 3 or less when expressed in terms of acetic acid mass / peracetic acid mass. The acetic acid mass / peracetic acid mass is preferably 1.2 or more and 2.5 or less, particularly preferably 1.4 or more and 2.3 or less.

When the endoscope disinfectant of the present invention is provided for the disinfection of an endoscope, it is not particularly limited, but it is preferably provided as a concentrated liquid and diluted as used as a disinfectant. .
In the concentrated liquid, the concentration of peracetic acid in the aqueous solution may be 7% by mass or more and 15% by mass or less, preferably 8% by mass or more and 14% by mass or less, and particularly preferably 9% by mass or more and 13% by mass or less. preferable.
In the concentrate, the hydrogen peroxide concentration of the aqueous solution may be 10% by mass to 30% by mass, preferably 13% by mass to 25% by mass, and more preferably 15% by mass to 23% by mass. Particularly preferred.

In the concentrated liquid, the concentration of acetic acid in the aqueous solution may be 10% by mass or more and 30% by mass or less, preferably 13% by mass or more and 25% by mass or less, and particularly preferably 15% by mass or more and 23% by mass or less. .
In use, the concentration of peracetic acid in the aqueous solution is preferably 0.1% by mass or more and 0.5% by mass or less, and more preferably 0.2% by mass or more and 0.4% by mass or less.
Therefore, the dilution ratio for diluting the concentrated solution may be 23 to 50 times, preferably 25 to 40 times, more preferably 30 to 35 times.

The endoscope disinfectant of the present invention may contain other components that do not affect the content ratio of acetic acid and peracetic acid. Examples of other components include stabilizers. Preferred examples of the stabilizer include orthophosphoric acid, pyrophosphoric acid, sulfuric acid and nitric acid. Of these, orthophosphoric acid and pyrophosphoric acid are particularly preferred.

As a solvent for diluting the endoscope disinfectant of the present invention provided as a concentrate, water is usually used.
At the time of dilution, an additive containing at least one selected from the group consisting of a buffer, a corrosion inhibitor, a pH adjuster, a sequestering agent, a stabilizer, and a surfactant is added to the second reagent. It is preferable to mix and dilute. Hereinafter, the endoscope disinfectant of the present invention provided in the form of a concentrate for comparison with the second reagent may be referred to as the first reagent.
For example, 50 ml of the first reagent, 50 ml of the second reagent, and 900 ml of water are mixed to prepare a disinfecting solution (practical solution) for disinfection or sterilization. In this case, since a practical solution of 50 ml to 1000 ml of the first reagent containing the equilibrium peracetic acid composition is prepared, it is diluted 20-fold when viewed from the first reagent.

When disinfecting an endoscope using a practical liquid, it is preferable to use an automatic washing machine.
The contact time between the practical liquid and the endoscope in the automatic washing machine is preferably 1 to 15 minutes, particularly preferably 4 to 11 minutes.

When disinfecting an endoscope, the practical liquid may be used only once and discarded, or may be discarded after repeated use. Preferably, the practical solution is used only once and discarded. Similarly, when disinfecting an endoscope using an automatic washing machine, it is set to discard the practical liquid that has come into contact with the endoscope every time the practical liquid and the endoscope are contacted multiple times. However, it is preferable to set so as to be discarded every contact. In terms of disinfection performance, the practical solution can be used repeatedly about 20 times, because disinfection with more sanitary disinfectants is increasing as market needs.

The second reagent is prepared as a reagent containing at least one selected from the group consisting of a buffer, a corrosion inhibitor, a pH adjuster, a sequestering agent, a stabilizer, a surfactant, and an anti-redeposition agent. Is done.

The buffering agent refers to an inorganic or organic acid or salt having pH buffering ability, and acid and alkali components necessary for pH adjustment. For example, citric acid, acetic acid, tartaric acid, malic acid, lactic acid, glycolic acid, succinic acid, glutaric acid, organic acid such as adipic acid or a salt thereof, inorganic acid such as phosphoric acid or sulfuric acid or a salt thereof, or ammonium hydroxide Alternatively, a base such as an alkali metal hydroxide can be used. Among these, the buffer preferably used in the present invention is citric acid, an organic acid of acetic acid or a salt thereof, an inorganic acid such as phosphoric acid or sulfuric acid or a salt thereof, and more preferably an inorganic acid of phosphoric acid or a salt thereof. . The concentration of the buffering agent is not particularly limited, but is preferably 20% by mass or less in the second reagent, particularly preferably 10% by mass or less, and preferably 2% by mass or less, and particularly preferably 1% by mass or less in the disinfectant solution composition.

Examples of the pH adjuster include acids that are compatible with the environment, such as citric acid, acetic acid, tartaric acid, malic acid, lactic acid, glycolic acid, succinic acid, glutaric acid, or adipic acid, and salts thereof, phosphoric acid. Inorganic acids such as sulfuric acid and salts thereof, and bases such as ammonium hydroxide or alkali metal hydroxide can be used. However, the pH adjuster that can be used in the present invention is not limited thereto. The concentration of the pH adjusting agent in the practical liquid is preferably 20% by mass or less, and particularly preferably 0.1% by mass to 10% by mass with respect to the total mass of the practical liquid.

A known stabilizer may be used as the stabilizer, and examples thereof include phosphate, 8-hydroxyquinoline, stannic acid, sulfolene, sulfolane, sulfoxide, sulfone, and sulfonic acid. In the second reagent, phosphate is a preferred stabilizer. Preferably, the concentration of the stabilizer in the practical solution may include about 0.001% by mass to about 0.5% by mass of phosphate with respect to the total mass of the practical solution. The phosphate is selected from the group consisting of sodium orthophosphate, potassium orthophosphate, sodium pyrophosphate, potassium pyrophosphate, sodium polyphosphate, potassium polyphosphate, and combinations thereof. The phosphate concentration in the second reagent is preferably 0.05 or more and 2.0 mol / L or less, and more preferably 0.1 or more and 1.0 mol / L or less.

As the surfactant, a surfactant that is stable against oxidation and decomposition in the presence of peroxycarboxylic acid and hydrogen peroxide in an acidic aqueous medium can be used. Preferably, a surfactant that is easily oxidized is used. avoid. Suitable surfactants can be selected from nonionic, anionic, amphoteric, or cationic surfactants.
Preferred surfactants to be added to the second reagent include nonionic surfactants, specifically, polyethylene / polypropylene block polymer type surfactants, polyoxyethylene alkylphenyl ether type surfactants. Agents, polyoxyethylene ether surfactants, and polyoxyethylene sorbitan surfactants. The surfactant added to the second reagent is not limited to these. The concentration of the surfactant in the practical liquid is not particularly limited, but may be about 1.0% by mass to about 30% by mass with respect to the total mass of the practical liquid.

In the present specification, the metal ion sequestering agent means a component that acts to sequester (chelate) metal ions, and even when these components have the ability to chelate calcium and magnesium, iron, manganese, and copper It means a component that binds more selectively to such heavy metal ions. The sequestering agent is 0.005% by mass to 20% by mass, preferably 0.1% by mass to 10% by mass, more preferably 0.25% by mass to 7.5% by mass, based on the total mass of the second reagent. %, Most preferably 0.5% to 5% by weight. Examples of the sequestering agent include organic phosphonates such as aminoalkylene poly (alkylene phosphonates), alkali metal ethane 1-hydroxydiphosphonates, and nitrilotrimethylene phosphonates. Of these, aminotri (methylenephosphonate), diethylenetriaminepenta (methylenephosphonate), ethylenediaminetri (methylenephosphonate), ethylenediaminetetra (methylenephosphonate), hexamethylenediaminetetra (methylenephosphone) are preferred. Acid), and hydroxy-ethylene 1,1 diphosphonate.

Other sequestering agents include nitrilotriacetic acid and polyaminocarboxylic acids such as ethylenediaminotetraacetic acid, ethylenetriaminepentaacetic acid, ethylenediamine disuccinic acid, ethylenediamine diglutaric acid, 2-hydroxypropylenediamine disuccinic acid, or any of these Salt. Particularly preferred is ethylenediamine-N, N′-disuccinic acid (EDDS) or an alkali metal salt, alkaline earth metal salt, ammonium salt or substituted ammonium salt thereof, or a mixture thereof.

Preferred other sequestering agents include, for example, 2-hydroxyethyldiacetic acid or glyceryliminodiacetic acid described in European Patent Publication No. 317,542 and European Patent Publication No.399,133. Iminodiacetic acid derivatives, iminodiacetic acid-N-2-hydroxypropylsulfonic acid and aspartic acid N-carboxymethyl N-2-hydroxypropyl-3-sulfonic acid blockade described in European Patent Publication No. 516,102 Agent, and β-alanine-N, N′-diacetic acid, aspartic acid-N, N′-diacetic acid, aspartic acid-N-monoacetic acid, and imino described in European Patent Publication No. 509,382 A disuccinic acid sequestering agent is mentioned. EP-A 476,257 describes a suitable amino-based blocking agent. EP-A 510,331 describes suitable blocking agents derived from collagen, keratin or casein. EP 528,859 describes a suitable alkyliminodiacetic acid sequestering agent. Also suitable are dipicolinic acid and 2-phosphonobutane-1,2,4-tricarboxylic acid. Also suitable are glycinamide-N, N'-disuccinic acid (GADS), ethylenediamine-N, N'-diglutaric acid (EDDG) and 2-hydroxypropylenediamine-N, N'-disuccinic acid (HPDDS). is there. However, the sequestering agent is not limited to the above examples.

  The second reagent preferably contains an organic phosphonic acid as a sequestering agent. Examples of the organic phosphonic acid include aminoalkylene poly (alkylenephosphonic acid), ethane 1-hydroxydiphosphonic acid, and nitrilotrimethylenephosphonic acid and alkali metal salts thereof. Of these, aminotri (methylenephosphonate), diethylenetriaminepenta (methylenephosphonate), ethylenediaminetri (methylenephosphonate), ethylenediaminetetra (methylenephosphonate), hexamethylenediaminetetra (methylenephosphone) are preferred. Acid), and ethane-1-hydroxy-1,1-diphosphonic acid (etidronic acid) and its alkali metal salt, particularly preferably ethane-1-hydroxy-1,1-diphosphonic acid (ethidronic acid) and its alkali It is a metal salt.

  As the corrosion inhibitor, those suitable for the material of the endoscope may be selected. For example, benzotriazole derivatives (1,2,3-benzotriazole, lower alkylbenzotriazole, hydroxybenzotriazole, lower alkylhydroxybenzo Triazole, carboxybenzotriazole, lower alkylcarboxybenzotriazole), benzimidazole, lower alkylbenzimidazole, hydroxybenzimidazole, lower alkylhydroxybenzimidazole, carboxybenzimidazole, lower alkylcarboxybenzimidazole, mercaptobenzothiazole, lower alkylmercaptobenzothiazole , Hydroxymercaptobenzothiazole, lower alkylhydroxymercaptobenzothiazole, carboxy Lucaptobenzothiazole, lower alkyl carboxymercaptobenzothiazole, sodium gluconate, sodium benzoate, butyl benzoate, monoethanolamine, triethanolamine, morpholine, sorbitol, erythritol, sodium phosphate, sodium tripolyphosphate, tetrasodium pyrophosphate , Sodium molybdate, sodium nitrite, sodium bisulfite, sodium metabisulfite, nitric acid, sodium nitrate, potassium nitrate, chromate or borate, or combinations of two or more substances selected from these Can be, but is not limited to. In the present specification, the term “lower alkyl” means a linear or branched saturated hydrocarbon group having 1 to 6 carbon atoms.

When the endoscope disinfectant of the present invention is used to sterilize an endoscope containing copper, brass, bronze, or a multimetallic system, a benzotriazole derivative (1,2,3-benzotriazole, lower Corrosion that is alkylbenzotriazole, hydroxybenzotriazole, lower alkylhydroxybenzotriazole), sodium molybdate, sodium nitrite, sodium bisulfite, sodium metabisulfite, chromate, or borate, or any combination thereof An inhibitor is preferably used. A corrosion inhibitor containing 1,2,3-benzotriazole, sodium molybdate, or sodium nitrite, or a combination thereof is particularly preferably used. When the endoscope disinfectant of the present invention is used for sterilizing equipment containing carbon steel and / or stainless steel, for example, sodium benzoate, sodium nitrite, and sodium molybdate, nitric acid, nitric acid A corrosion inhibitor containing sodium, potassium nitrate or the like is preferably used. When the endoscope disinfectant of the present invention is used to sterilize equipment containing carbon steel and / or stainless steel, for example, corrosion prevention containing nitric acid, potassium nitrate, sodium nitrate and / or sodium molybdate An agent is preferably used.
The addition amount of the corrosion inhibitor is preferably 0.1 to 10% by mass, more preferably 0.3 to 5% by mass in the second reagent.

When the corrosion inhibitor is hardly soluble in the second reagent, it may further contain a solubilizer such as alkylene glycol. As used herein, the term “alkylene glycol” refers to, for example, ethylene glycol, propylene glycol, dialkylene glycol (such as diethylene glycol), or trialkylene glycol (such as triethylene glycol), or the corresponding mono- and Glycols such as dialkyl ethers. Alkyl ethers are lower alkyl ethers having 1 to 6 carbon atoms (such as methyl ether, ethyl ether, or propyl ether). Particularly preferably, propylene glycol is contained as a solubilizing agent, and this propylene glycol is preferably contained in the practical liquid at a concentration of about 3 to 10 times that of the corrosion inhibitor. For example, it is preferable that propylene glycol is contained in the practical liquid in an amount of 1% by mass to 6% by mass with respect to 1,2,3-benzotriazole contained in about 2% by mass, and particularly preferably 1.5% by mass. % To 4% by mass.

As the anti-reattachment agent, those having a function of keeping dirt and the like detached from the endoscope suspended in the liquid can be used. For example, organic water-soluble colloids (eg, starch, gelatin, or ether carboxylic acid or ether sulfonic acid salt such as starch, cellulose, cellulose ether, or ether carboxylic acid or ether sulfonic acid salt of cellulose, or cellulose or An acidic sulfate ester salt of starch) can be used. A water-soluble polyamide containing an acidic group can also be preferably used. Furthermore, starch derivatives other than those described above, such as aldehyde starch, can also be used. However, the anti-redeposition agent that can be added is not limited to these examples. As the anti-redeposition agent, one or more selected from the group consisting of the above compounds exemplified as the anti-redeposition agent can be used. The concentration of the anti-redeposition agent is preferably 5% by mass or less, particularly preferably 2% by mass or less, based on the total mass of the second reagent.

As used herein, the term “disinfection” includes meanings such as “cleaning”, “sterilization”, and “sterilization”.
An endoscope disinfection method using the endoscope disinfectant of the present invention is not particularly limited, but a method of disinfecting an endoscope by immersing the endoscope in the endoscope disinfectant of the present invention is preferable. . In the immersion, the endoscope disinfectant may be agitated, the endoscope may be shaken, or an automatic washing machine may be used. In addition, a step of washing the endoscope before or after the immersion may be included, and a step of wiping the endoscope after the immersion with sterilized gauze or the like or drying it with a dryer or the like may be included. The immersion time may be from 1 minute to 15 minutes, preferably from 3 minutes to 12 minutes, and more preferably from 4 minutes to 6 minutes.

Examples of the present invention will be described below, but the present invention is not limited to the following examples.
(Example 1)
Reagents having the composition described in Table 1 were prepared as the first reagent (concentrated liquid).

Each of the four first reagents shown in Table 1 was placed in a polyethylene container capable of venting 1 liter. Changes in the concentration of peracetic acid after elapse of time under the condition of 50 ° C. of these reagents were examined.
Peracetic acid concentration was determined by redox titration. The titration method is as follows. The results are shown in FIG. From FIG. 1, it can be seen that reagents 3 and 4 have high peracetic acid concentration stability.

<Peracetic acid concentration determination method>
1 ml of a sample was taken with a micropipette and diluted to 20 ml with pure water using a volumetric flask.
1 ml of a sample diluted 20 times in a 200 ml conical beaker was collected with a micropipette, and 20 ml of 10% sulfuric acid was added.
One to two drops of a ferroin indicator were added thereto, and titrated with a 1 / 10N cerium sulfate standard solution. The point where the color changed from red to light blue was defined as the end point (Aml).
Next, 1 ml of the disinfectant solution was collected in a separate 200 ml conical beaker with a micropipettor, 20 ml of 10% sulfuric acid, 10 ml of 10% potassium iodide solution, and 1 to 2 drops of 5% ammonium molybdate solution were added to this. The solution was titrated with a 10N sodium thiosulfate standard solution until pale yellow, and about 1 ml of 1% starch solution was added, and the point at which the dark blue color disappeared was defined as the end point (Bml). The concentration of peracetic acid was determined by the following formula.

Peracetic acid (w / v% (mass%)) = (B x f2-A x f1) x 0.05 x 76
× 100/1000

Where f1 is a factor of 1 / 10N cerium sulfate standard solution,
f2 represents a factor of 1 / 10N sodium thiosulfate standard solution.

(Example 2)
A practical solution was prepared using the first reagent used in Example 1. Samples with a time period of 0, 32, and 99 days for Reagents 2 and 3 were used. Reagent 2 (50 ml), the following second reagent 50 ml, and a solution made up to 1 L by adding ion-exchanged water, and reagent 3 (26 ml), the following second reagent 50 ml, and ion-exchanged water added to make 1 L A prepared liquid was prepared. That is, a solution in which reagent 2 was diluted 20 times and a solution in which reagent 3 was diluted 38 times were prepared.

Second reagent: 1 L was prepared by adding ion-exchanged water to the composition shown in Table 2 below. The prepared liquid had a pH of 8.7, a specific gravity of 1.07, and an electric conductivity of 5.4.

  FIG. 2 shows the change in peracetic acid concentration when 1 L of each practical solution prepared above was placed in a high-density polyethylene container (2 L capacity) and stored at 25 ° C. and 55% RH (relative humidity) for 13 days.

  If the peracetic acid concentration is too low as a peracetic acid disinfectant for endoscopes, the sterilization ability is lowered and sterilization cannot be guaranteed. Further, when the concentration is too high, the endoscope member is damaged when repeated disinfection is performed. Therefore, in a practical liquid, the peracetic acid density | concentration needs to be the range of 0.2-0.4 mass%.

The reagent 2 of the comparative example was diluted immediately after preparation, and the practical solution maintained an effective concentration in the range of 0.2 to 0.4% by mass for 13 days, but at 50 ° C. for 32 days. The diluted practical solution after the lapse of time can maintain the effective concentration only for about 4 days, and the diluted practical solution after 99 days at 50 ° C. has an effective concentration of peracetic acid already at the time of preparation. It was lower.
On the other hand, the effective concentration of Reagent 3 is about 12 days for both the diluted practical solution after 50 days at 50 ° C. and the diluted practical solution after 99 days at 50 ° C. It was kept. From this result, it can be seen that the endoscope disinfectant of the present invention has little peracetic acid concentration fluctuation over time even in a concentrated solution, and can be disinfected or sterilized with good reproducibility over a long period of time.

(Example 3)
In the same procedure as in Example 2, practical solutions were prepared on a 15 liter scale from samples with a time-lapse period of Reagent 2 and Reagent 3 of 0 days and 32 days, respectively, and left for 3 days. Using these four types of practical liquids after being left in place, using an endoscope automatic cleaning machine, bringing the endoscope into contact with the practical liquid for 5 minutes, cleaning the endoscope, and disinfecting, resulting in no problems. It was confirmed that it could be disinfected.

(Example 4)
Using the same procedure as in Example 2, practical solutions were prepared on a 15 liter scale from the samples with the time periods of Reagent 2 and Reagent 3 being 0 days and 32 days, respectively. As a result of using an endoscope automatic cleaning machine, the endoscope was brought into contact with a practical solution for 5 minutes, and the endoscope was cleaned and disinfected. As a result, it was confirmed that the endoscope could be cleaned and disinfected without any problems. Disinfectant was discarded after a single use.

It is a graph which shows the peracetic acid concentration change on 50 degreeC conditions of the reagent of the composition shown in Table 1. It is a graph which shows the peracetic acid density | concentration change at the time of preserve | saving for 13 days at 25 degreeC55% RH of the practical liquid containing the reagent 2 or 3 shown in Table 1, and the 2nd reagent shown in Table 2. FIG.

Claims (7)

An endoscope disinfectant comprising an aqueous solution containing acetic acid, peracetic acid and hydrogen peroxide, wherein the mass ratio of acetic acid to peracetic acid is 1: 1 to 3: 1 (acetic acid mass: peracetic acid mass) Endoscope disinfectant that is. The endoscope disinfectant according to claim 1, wherein the peracetic acid concentration is 7 mass% or more and 15 mass% or less. The endoscope disinfectant according to claim 1 or 2, and selected from the group consisting of a buffer, a corrosion inhibitor, a pH adjuster, a sequestering agent, a stabilizer, an anti-redeposition agent, and a surfactant. An endoscope disinfection kit comprising an additive containing one or more of the above. The kit according to claim 3, wherein the composition contains an organic phosphonic acid. The kit according to claim 3 or 4, wherein the composition contains a benzotriazole derivative. A method for disinfecting an endoscope to a high level, comprising the step of bringing a disinfectant containing the endoscope disinfectant according to claim 1 or 2 into contact with the endoscope in an automatic washing machine for 1 to 15 minutes. The method according to claim 6, wherein the disinfecting solution brought into contact with the endoscope is discarded for each contact.