CN115804820A - Pharmaceutical composition for treating wind-heat dry cough and preparation and application thereof - Google Patents

Abstract

The invention discloses a pharmaceutical composition for treating wind-heat dry cough, a preparation and an application thereof, wherein the pharmaceutical composition comprises the following components in parts by weight: 3-10 parts of ephedra, 6-15 parts of almond, 8-15 parts of roasted white mulberry root-bark, 8-15 parts of roasted snakegourd peel, 8-15 parts of wine-processed scutellaria baicalensis, 6-15 parts of thunberg fritillary bulb, 8-15 parts of isatis root, 6-15 parts of blackberry lily, 8-15 parts of radix peucedani, 6-15 parts of platycodon grandiflorum, 6-15 parts of dandelion, 6-30 parts of hairyvein agrimony, 8-15 parts of reed rhizome and 3-10 parts of liquorice, and the pharmaceutical composition can be added with pharmaceutically acceptable auxiliary materials to prepare a preparation. The pharmaceutical composition and the preparation can be used for preparing a traditional Chinese medicine preparation for treating wind-heat dry cough.

Description

Pharmaceutical composition for treating wind-heat dry cough and preparation and application thereof

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a pharmaceutical composition for treating wind-heat dry cough, and a preparation and application thereof.

Background

Cough is one of the main symptoms of lung diseases, such as lung qi failing to disperse and descend, adverse rising of lung qi, cough with sputum. The first discussions about cough are found in the "Nei Jing" (Nei Jing), as stated in the "Su Wen & Xuan Ming Wu Qi Lun": the heart is belching, the lung is coughing, the liver is swallowing, the spleen is swallowing, and the kidney is under … …. The location of cough is indicated in the lung. Understanding the etiology of cough, su Wen & Ke Lun states that cough is caused by the combination of lung and skin hair, and the skin hair is affected by pathogenic qi first and then by pathogenic qi. "five zang-organs and six fu-organs all cause cough, and not only lung. The "cough of five zang organs and six fu organs" all gather in the stomach, and the lung refers to the condition that the cough can be caused by the invasion of exogenous pathogenic factors into the lung, and the cough can be caused by the influence of other viscera and dysfunction on the lung, and the cough is not only limited to the lung, but also not separated from the lung. Cough is classified into external cold and internal injury. Whether the pathogenic factors enter from the outside or from the inside, they can cause the lung failing to disperse and descend and the adverse ascending of lung qi resulting in cough.

In recent years, the incidence of cough has been increasing year by year due to environmental pollution, climate change, and other factors, and extensive research has been conducted in the medical field. The ' doctor Bing Bian Zhi san, sang Ju Yin, sang xing Tang and Zhi Shu san are published in 2011, and the ' doctor Bian Zhi ' issued in cough TCM diagnosis and treatment expert opinion is to classify exogenous cough into the syndrome of wind-cold attacking the lung, the syndrome of wind-heat invading the lung, the syndrome of dryness-heat damaging the lung and the syndrome of wind-dryness damaging the lung by three strongotia, the Zhi Shu san, the sang Ju Yin, the sang xing Tang and the Zhi Shu san are respectively subjected to plus-minus treatment. Exogenous cough is acute in onset, short in course of disease, light in illness state and strong in healthy qi, and if timely and correctly treated, the cough is generally easy to cure. If the delayed action, delayed treatment, repeated attacks, and impairment of healthy qi can transform from cough with external contraction to cough with internal injury, the pathogenesis changes from excess to deficiency, and the location of the disease also changes from lung to other zang organs. Therefore, it is very important to treat exogenous cough effectively and timely.

It is worth pointing out that in addition to the simple syndrome of wind-cold, wind-heat, dryness-heat and wind-dryness, the mixed and complicated syndrome of pathogenic factors are also common. Wind is yang pathogen, which is mild in nature and easy to rapidly transform into heat, and cold pathogen often accompanies with syndrome of both cold and heat and miscellaneous diseases such as lung heat; from clinical observation, there are not few cases of two kinds of exogenous pathogens.

The climate environment, economic conditions, the change of people's constitution and the change of diseases, the humidity of Kunming area is 30% -50% lower than that of coastal area, the climate is drier, the four seasons are all very dry, and in addition, people like Xin Sao and the environment is polluted, so the patients with lung heat and lung dryness are more. Li Gufeng is clinically seen, most of cough is caused by wind, heat and dryness which are combined to invade human body. It has the functions of clearing away heat, dispersing lung qi, moistening dryness, eliminating phlegm, relieving cough and asthma.

The Chinese and western patent medicines for eliminating phlegm and stopping cough in the market are various in variety, the components are mostly overlapped, and the use of part of non-prescription medicines is influenced by factors such as commercial advertisements and the like. The habituation medicines with regional differences also permeate each other. Under the background, repeated and unreasonable use of expectorant and antitussive medicine is inevitable, and especially for outpatient patients, the problem of medicine safety has attracted more and more attention of experts at home and abroad. For example, the addiction of western medicine codeine is a problem to be solved urgently in clinic, with the development of medical science, the varieties of medicines are increasing day by day, and the phenomenon of combination of Chinese medicines and western medicines is more common in clinic. If the medicine is reasonably used, the curative effects can be mutually promoted, the synergistic effect is enhanced, and the effects of attenuation and detoxification can be achieved, so that the toxic and side effects of the medicine are reduced. However, improper combination of the ingredients will reduce the drug effect, cause toxic and side effects or other adverse reactions, and even cause drug-induced diseases. For the liver and kidney damage caused by drugs, it should be used with cautions.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine composition for treating wind-heat dry cough, a preparation and an application thereof, and the traditional Chinese medicine composition has the aim of clinical treatment by clearing heat, ventilating lung, moistening dryness, eliminating phlegm, relieving cough and asthma.

The purpose of the invention is realized by the following technical scheme:

a pharmaceutical composition for treating wind-heat dry cough comprises the following components in parts by weight: 3-10 parts of ephedra, 6-15 parts of almond, 8-15 parts of roasted white mulberry root-bark, 8-15 parts of roasted snakegourd peel, 8-15 parts of wine-processed scutellaria baicalensis, 6-15 parts of thunberg fritillary bulb, 8-15 parts of isatis root, 6-15 parts of blackberry lily, 8-15 parts of radix peucedani, 6-15 parts of platycodon grandiflorum, 6-15 parts of dandelion, 6-30 parts of hairyvein agrimony, 8-15 parts of reed rhizome and 3-10 parts of liquorice. The above components are the basic recipe for the present application.

A pharmaceutical composition for treating wind-heat dry cough comprises 8 to 12 parts of radix bupleuri in addition to the basic formula.

A pharmaceutical composition for treating wind-heat dry cough comprises 8 to 12 parts of stiff silkworm and 5~7 parts of cicada slough in addition to the basic formula.

A pharmaceutical composition for treating wind-heat dry cough comprises 8 to 12 parts of honey aster and 8 to 12 parts of honey winter flower in addition to the basic formula.

A pharmaceutical composition for treating wind-heat dry cough comprises 8 to 12 parts of burdock and 8 to 12 parts of oroxylum indicum besides the basic formula.

A pharmaceutical composition for treating wind-heat dry cough comprises 5~8 parts of earthworm and 2~4 parts of scorpion in addition to the basic formula.

A pharmaceutical composition for treating wind-heat dry cough comprises 12 to 20 parts of radix ophiopogonis in addition to the basic formula.

A preparation of a pharmaceutical composition for treating wind-heat dry cough is prepared by adding pharmaceutically acceptable auxiliary materials into the pharmaceutical composition.

A preparation method of the preparation comprises the following steps:

step (1): taking fourteen medicines, adding wine scutellaria baicalensis at last, adding water, decocting for three times, 1 to 1.2 hours each time, wherein the water adding amount for the first time is 8~9 times of the medicinal material amount, the water adding amount for the second time is 7~8 times of the medicinal material amount, the water adding amount for the third time is 7~8 times of the medicinal material amount, filtering decoction, and combining filtrates;

step (2): the filtrate is concentrated into an extract with the relative density of 1.26 +/-0.02, and the thick paste rate is 36-44%.

And (3): drying the above extract (at a temperature of less than or equal to 80 deg.C) to obtain dry extract;

and (4): pulverizing the dry extract into fine powder;

and (5): wet granulating, adding sucrose, dextrin, ethanol and water into dry extract powder, mixing, and making into soft material; making soft material into granules by swing type granulator, boiling and drying, sieving dry granules, grading, and mixing;

and (6) taking the granules, and subpackaging to obtain the traditional Chinese medicine composition.

The pharmaceutical composition is used for preparing a medicine for treating wind-heat dry cough.

The preparation is used for preparing a medicine for treating wind-heat dry cough.

The lung is involved in the nose, governs respiration, mainly clears and lowers the body's function, and is the upper source of water, and the lung also governs the opening and closing of skin and hair, so as to regulate water passage, transport bladder downward, and direct qi downward and reverse qi upward. The lung is the clear and descending viscera, prefers warm and aversion to cold, prefers moistening and dislike to dryness, and the exogenous wind pathogen enters the lung, which leads to cough. The lung opens into the nose and governs respiration, mainly clearing and descending, which is the upper source of water, and opens and closes the skin and hair, which governs qi transformation of the whole body, regulating water passage, transporting bladder downward, descending qi as the normal, ascending qi as the reverse. The lung governs respiration, five qi enter nose and enter heart and lung, so all invisible qi, visible flavor, pungent, dry and drastic smell can directly attack lung. On the contrary, the pathogenic factors in the lung can be excreted from the outside through respiration and sweat. However, the lung is not open after it is infected with pathogenic factors, the nasal obstruction is obstructed, the striae of the skin is not open, and the lung is not released. At this time, it is necessary to disperse lung qi to open the striae and relieve "sweat in the palms". The exterior cold will transform into heat, the sweat will stop, the water will transform into qi when it is hot, and the qi will transform into water when it is cold.

In the formula, the ephedra is used as a monarch drug to disperse, open and ventilate lung qi, expel pathogenic factors and relieve cough and asthma. Ephedra, almond phase Wu Xuanfei relieve asthma; cortex Mori and Scutellariae radix Wu Qingxie are effective in clearing lung-heat, relieving cough and asthma; zhejiang fritillaria bulb and snakegourd fruit shell are combined for moistening lung, clearing heat, reducing phlegm, relieving cough and the like; embodies the idea that treating cough attaches importance to ventilating lung and opening doors to prevent 'closing doors and keeping the mouth with the hands', and adopts multiple methods to remove evil and restore the body resistance.

The ephedra herb is pungent, slightly bitter and warm in taste. It enters lung and bladder meridians. Dispersing, opening and ventilating lung qi, expelling pathogenic factors and relieving cough and asthma are monarch drugs. The modern pharmacological ephedra contains ephedrine as main component and small amount of pseudoephedrine, volatile oil, etc. The ephedra volatile oil has the effect of sweating, and the ephedrine can increase the secretion of sweat glands of a person in a high-temperature environment and accelerate the secretion. The herba Ephedrae volatile oil emulsion has antipyretic effect. Ephedrine and pseudoephedrine both have effects of relieving spasm of bronchial smooth muscle. The volatile oil has effect in inhibiting influenza virus.

The bitter and warm almond is moist, can reduce and promote lung qi, can moisten dryness and relieve cough, the mulberry bark can clear heat, purge lung and relieve asthma, the roasted snakegourd fruit shell can moisten lung and reduce phlegm, and can promote qi and relieve chest stuffiness as ministerial drugs, so that the bitter and warm almond can clear heat, reduce phlegm, and relieve cough and asthma. Wherein, the ephedra and the almond are compatible, one can disperse and descend, and the other can restore the lung-qi to disperse and descend, so as to enhance the effects of dispersing lung qi and relieving asthma.

The whiteflower hogfennel root disperses wind-heat, lowers qi and reduces phlegm, the platycodon root disperses lung qi, and relieves cough and asthma, the medicine is carried upwards, the baical skullcap root is good at clearing lung fire and excessive fire in upper jiao, the thunberg fritillary bulb is good at clearing lung heat, and the phlegm and cough are reduced to help clear lung heat, reduce phlegm and relieve cough; the dandelion has the functions of clearing away heat and toxic materials, reducing swelling and dissipating toxin, the blackberrykiky rhizome and the isatis root have the functions of clearing away heat and toxic materials, eliminating phlegm and relieving sore throat, and are all products for clearing away heat and toxic materials, and can help monarch and minister drugs to reach the exterior, clear away heat, moisten lung and relieve sore throat and detoxify; herba et Gemma Agrimoniae has effects of tonifying deficiency and removing toxic substance, and is used as adjuvant drug for treating dryness-heat damaging fluid, and rhizoma Phragmitis has effects of clearing heat and promoting fluid production. Wherein the agrimony can not only help healthy qi to dispel pathogenic factors, but also can tonify the pathogenic factors, so as not to damage genuine vigor.

Licorice root, radix Glycyrrhizae can relieve the property of a drug and clear away heat and toxic materials, and is used as a guiding drug.

The invention has the beneficial effects that:

the traditional Chinese medicine composition integrates the functions of dispersing lung qi, moistening lung, clearing heat, reducing phlegm and descending qi, and achieves the effects of clearing heat, dispersing lung qi, moistening dryness, eliminating phlegm, relieving cough and asthma. Ephedra, almond phase Wu Xuanfei relieve asthma; cortex Mori and Scutellariae radix Wu Qingxie are effective in clearing lung-heat, relieving cough and asthma; zhe Bei mu and Gua Lou Chi are combined to moisten lung and clear heat, resolve phlegm and stop cough. The combination of the herbs can disperse and descend the lung qi and remove wind-heat dryness and recover the lung fluids, so all the symptoms can be healed.

Detailed Description

The present invention will be further described with reference to the following examples, but the present invention is not limited to these examples.

Example 1

A pharmaceutical composition for treating wind-heat dry cough comprises the following components: 3g of ephedra, 6g of almond, 8g of fried white mulberry root-bark, 8g of fried snakegourd peel, 8g of wine-processed baical skullcap root, 6g of thunberg fritillary bulb, 8g of indigowoad root, 6g of blackberry lily, 8g of whiteflower hogfennel root, 6g of platycodon root, 6g of dandelion, 6g of hairyvein agrimony, 8g of reed rhizome and 3g of liquorice.

Example 2

A pharmaceutical composition for treating wind-heat dry cough comprises the following components: 8g of ephedra, 10g of almond, 12g of fried white mulberry root-bark, 12g of fried snakegourd peel, 12g of wine-processed baical skullcap root, 12g of thunberg fritillary bulb, 12g of indigowoad root, 12g of blackberry lily, 12g of whiteflower hogfennel root, 12g of platycodon root, 12g of dandelion, 18g of hairyvein agrimony, 13g of reed rhizome and 7g of liquorice.

Example 3

A pharmaceutical composition for treating wind-heat dry cough comprises the following components: 10g of ephedra, 15g of almond, 15g of fried white mulberry root-bark, 15g of fried snakegourd peel, 15g of wine-processed baical skullcap root, 15g of thunberg fritillary bulb, 15g of indigowoad root, 15g of blackberry lily, 15g of whiteflower hogfennel root, 15g of platycodon root, 15g of dandelion, 30g of hairyvein agrimony, 15g of reed rhizome and 10g of liquorice.

Example 4

A pharmaceutical composition for treating wind-heat dry cough is prepared by adding 10g bupleuri radix in example 3.

Example 5

A pharmaceutical composition for treating wind-heat dry cough is prepared by adding 10g of stiff silkworm and 6g of cicada slough into the composition in example 1.

Example 6

A pharmaceutical composition for treating wind-heat dry cough is prepared by adding 10g of fructus arctii and 10g of semen oroxyli into the composition in example 2.

Example 7

A pharmaceutical composition for treating wind-heat dry cough is prepared by adding 10g of honey-fried aster and 10g of honey-fried winter flower into the above mixture in example 3.

Example 8

A pharmaceutical composition for treating wind-heat dry cough is prepared by adding 6g of earthworm and 3g of scorpion into the mixture in example 2.

Example 9

A pharmaceutical composition for treating wind-heat dry cough is prepared by adding 15g of radix ophiopogonis into the pharmaceutical composition in example 1.

Example 10

A pharmaceutical composition preparation is prepared by taking the pharmaceutical composition of any one of embodiments 1-3, decocting with water for three times, each time for 1 hour, wherein the water addition amount for the first time is 8 times of the medicinal material amount, the water addition amount for the second time is 7 times of the medicinal material amount, the water addition amount for the third time is 7 times of the medicinal material amount, filtering decoction, and mixing filtrates;

the filtrate is concentrated into an extract with the relative density of 1.26 +/-0.02, and the thick paste rate is 36-44%.

Drying the above extract (at a temperature of less than or equal to 80 deg.C) to obtain dry extract;

pulverizing the dry extract into fine powder;

wet granulating, adding sucrose, dextrin, ethanol and water into dry extract powder, mixing, and making into soft material; making soft material into granules by swing type granulator, boiling and drying, sieving dry granules, grading, and mixing;

and (6) taking the granules, and subpackaging to obtain the preparation.

Application example-observation of the clinical efficacy and adverse reactions of the application (ephedra and apricot antitussive formula) for treating wind-heat dry cough.

1. Study object

The case selection standard is formulated by referring to the standard of curative effect for diagnosis of disease and symptoms of traditional Chinese medicine.

2. Diagnostic criteria

1. Diagnostic criteria of traditional Chinese medicine

(1) Cough with noise, or itching throat and expectoration.

(2) Cough due to exogenous pathogenic factors may be accompanied by exterior syndromes such as cold and heat.

(3) Auscultation of both lungs can smell and increase the breath sound, or accompanied by dry and damp rales.

2. Syndrome differentiation of traditional Chinese medicine

According to the internal science of traditional Chinese medicine and the syndrome differentiation standard of Li Gufeng for treating cough diseases for a long time, the main manifestations of wind-heat dry cough are determined as follows:

the main symptoms are: cough, choking or paroxysmal cough; little or no sputum; a red tongue with a thin yellow or yellow greasy coating and a superficial, rapid or thready and rapid pulse.

The secondary symptoms are as follows: dry and itchy throat, sore throat, fever, dry stool.

3. Inclusion criteria

(1) Age: is more than or equal to 18 years old and less than or equal to 65 years old;

(2) The Chinese medicine composition meets the Chinese medicine diagnosis standard and the Chinese medicine syndrome differentiation standard of the disease;

(3) No other drug treatment;

(4) Patients can agree with the information and can be matched as required;

4. exclusion criteria

(1) Patients with other serious primary diseases of lung

(2) Women aged 18 or 65 years old or older, pregnant or lactating, who are allergic to the drug.

(3) Patients with serious primary diseases such as cardiovascular diseases, liver diseases, kidney diseases, hemopoietic system diseases and the like are combined.

(4) If the drug is not in accordance with the inclusion criteria, the drug is not administered according to the regulations, and the efficacy or safety of the drug cannot be judged.

8. Method of administration

The oral administration of the ephedra and apricot antitussive formulation is made into traditional Chinese medicine granules which are taken 1 hour after meals, one bag each time and 2 times a day, and the granules are taken with boiled water.

9. Criteria for therapeutic effect

(1) And (3) curing: after the medicine is taken for 6-8 days, symptoms such as fever, cough and the like disappear.

(2) The effect is shown: after the medicine is taken for 8-10 days, the cough symptom is obviously relieved.

(3) And (4) invalidation: the medicine is taken for more than 10 days, and symptoms such as cough and the like are not obviously relieved or aggravated.

10. Summary of clinical effects

The study included a total of 110 patients. In the prescription of ephedra and apricot for relieving cough, 62 cases (56.4%) are clinically cured, 40 cases (36.4%) are remarkably effective, and 8 cases (7.2%) are ineffective. After the treatment is finished, the total effective rate of the treatment of 110 patients is 92.8%. Clinical curative effect statistical table

1.

2. For the above cases, if the patient has fever, 10g of bupleurum can be added according to the situation;

3. if the patient has the situation of dry and itchy throat, 10g of stiff silkworm and 6g of cicada slough can be added;

4. 10g of burdock and 10g of semen oroxyli can be added for patients with throat pain;

5. if patients have severe cough, 10g of aster honey and 10g of winter honey flower are added;

6. for patients suffering from choking cough or paroxysmal cough, 6g of earthworm and 3g of scorpion are added;

7. 15g of dwarf lilyturf tuber can be added if the patient has dry stools.

In the treatment of diseases in traditional Chinese medicine, the treatment based on syndrome differentiation is studied, and the treatment is carried out according to the syndrome, wherein the treatment is carried out by using the medicine for some syndromes. This shows that the classical prescriptions of TCM are not deduced from yin and yang, but from the syndrome of disease, the more targeted drugs are selected. The syndrome is single, the medication is single, the syndrome is complex, and the medication is also complex. Therefore, any classical prescription can be added or subtracted according to clinical practice, and not only the drugs can be added or subtracted, but also the dosage of the drug can be added or subtracted. In a word, the traditional Chinese medicine is the active science of syndrome differentiation, and the clinical syndrome differentiation treatment needs wide thought, flexible application and contraindication of handling.

In clinic, in the course of the occurrence and development of each disease, due to the differences in the struggle between the pathogenic factors and the vital qi and the innate endowments, living, working conditions and emotional changes of the patients, different patients and the same patient may have different symptoms at different stages, and the patients must be modified or reduced according to the disease changes to achieve good therapeutic effects. If the physician is prohibited from observing the Chinese characters with the rules of containment, the physician should be able to treat the pathological changes according to the syndrome differentiation of the patients.

Therefore, the corresponding embodiments cannot be listed in the curative effect statistical table in this application, and for those skilled in the art, the corresponding therapeutic effect can be achieved by performing addition or subtraction according to different patients according to different symptoms within the dosage and the dosage range defined in this application.

11. Adverse reactions

Clinical application shows no toxic side effect and untoward effect.

12. Typical cases

1. Li Mou, male, 60 years old.

Initial diagnosis: 10 and 25 months in 2019

A chief complaint: cough for 1 month.

The current medical history: before 1 month, the symptoms of pharyngalgia, dry throat, cough and little phlegm appear due to the careless cold. The symptoms are that the cough is severe and paroxysmal, and the cough has little sputum, no chest distress and chest pain, dry mouth and throat and no aversion to cold and fever.

A red tongue tip, thin and yellow coating and a rapid pulse.

And (3) diagnosis: cough (wind-heat dry cough)

Prescription: 10g of ephedra, 15g of almond, 15g of fried white mulberry root-bark, 15g of fried snakegourd peel, 10g of wine-processed baical skullcap root, 15g of thunberg fritillary bulb, 15g of indigowoad root, 10g of blackberry lily, 10g of whiteflower hogfennel root, 10g of platycodon root, 15g of dandelion, 30g of hairyvein agrimony, 15g of reed rhizome and 10g of liquorice

3-dose formula granule

The usage and dosage are as follows: the preparation 1 is packaged into 4 bags twice a day, one bag at a time, and taken one hour after meal.

Ordering: spicy fried food is avoided.

And B, diagnosis: 11/2019/month and 4/day

When the medicine is taken, the symptoms are obviously relieved, the cough is occasionally caused, and the pharynx is not dry and itchy.

The tongue tip is red and the coating is white. The pulse is slow.

Diagnosis is as before

Prescription: prescription: 10g of ephedra, 15g of almond, 15g of fried white mulberry root-bark, 15g of fried snakegourd peel, 10g of wine-processed baical skullcap root, 15g of thunberg fritillary bulb, 15g of indigowoad root, 10g of blackberry lily, 10g of whiteflower hogfennel root, 10g of platycodon root, 15g of dandelion, 30g of hairyvein agrimony, 15g of reed rhizome and 10g of liquorice

2-dose formula granule

The usage and dosage are as follows: the preparation 1 is packaged into 4 bags twice a day, one bag at a time, and taken one hour after meal.

Ordering: spicy fried food is avoided.

One week later, the telephone tells that the normal state is recovered.

2. Wang Mou, female, age 75.

Initial diagnosis: 3/10/2020

The main complaints are: cough for 2 months.

The current medical history: before 2 months, the patient suffers from pharyngalgia and cough due to careless diet, and the pharyngalgia is relieved and the cough still occurs after taking western medicines and Chinese patent medicines, so that the patient is in a traditional Chinese medicine library to see a doctor. Cough with paroxysmal cough without phlegm, dry and itchy throat, obvious night influence on sleep. Convenient adjustment can be realized.

Red tongue tip, thin and yellow coating and rapid pulse.

And (3) diagnosis: cough (wind-heat dry cough)

Prescription: prescription: 10g of ephedra, 10g of almond, 10g of fried white mulberry root-bark, 10g of fried snakegourd peel, 10g of wine-processed baical skullcap root, 10g of thunberg fritillary bulb, 10g of indigowoad root, 10g of blackberry lily, 10g of whiteflower hogfennel root, 10g of platycodon root, 10g of dandelion, 30g of hairyvein agrimony, 15g of reed rhizome and 10g of liquorice

5-dose formula granule

The usage and dosage are as follows: the preparation 1 is packaged into 4 bags twice a day, one bag at a time, and taken one hour after meal.

Ordering: spicy fried food is avoided.

A call return visit of 25/3/2020 tells that the cough has been cured.

Claims (10)

1. A pharmaceutical composition for treating wind-heat dry cough is characterized by comprising the following components in parts by weight: 3-10 parts of ephedra, 6-15 parts of almond, 8-15 parts of roasted white mulberry root-bark, 8-15 parts of roasted snakegourd peel, 8-15 parts of wine-processed scutellaria baicalensis, 6-15 parts of thunberg fritillary bulb, 8-15 parts of isatis root, 6-15 parts of blackberry lily, 8-15 parts of radix peucedani, 6-15 parts of platycodon grandiflorum, 6-15 parts of dandelion, 6-30 parts of hairyvein agrimony, 8-15 parts of reed rhizome and 3-10 parts of liquorice.

2. A pharmaceutical composition for treating wind-heat dry cough is characterized by further comprising 8-12 parts of radix bupleuri.

3. The pharmaceutical composition for treating wind-heat dry cough is characterized by further comprising 8 to 12 parts of stiff silkworm and 4736 parts of cicada slough 5~7.

4. The pharmaceutical composition for treating wind-heat dry cough is characterized by further comprising 8-12 parts of honey aster and 8-12 parts of honey winter flower.

5. The pharmaceutical composition for treating wind-heat dry cough is characterized by further comprising 8-12 parts of burdock and 8-12 parts of oroxylum indicum.

6. The pharmaceutical composition for treating wind-heat dry cough is characterized by further comprising 3238 parts of earthworm and 3262 parts of scorpion.

7. The preparation of the pharmaceutical composition for treating wind-heat dry cough according to claim 1, wherein the preparation is prepared by adding pharmaceutically acceptable auxiliary materials into the pharmaceutical composition.

8. A method of preparing the formulation of claim 2, comprising the steps of:

step (1): taking fourteen medicines, adding wine scutellaria baicalensis finally, adding water, decocting for three times, 1 to 1.2 hours each time, wherein the water adding amount for the first time is 8~9 times of the medicinal materials, the water adding amount for the second time is 7~8 times of the medicinal materials, the water adding amount for the third time is 7~8 times of the medicinal materials, filtering decoction, and combining filtrate;

step (2): concentrating the filtrate to obtain extract with relative density of 1.26 + -0.02 and soft extract rate of 36-44%;

and (3): drying the above extract (at a temperature of less than or equal to 80 deg.C) to obtain dry extract;

and (4): pulverizing the dry extract into fine powder;

and (5): wet granulating, adding sucrose, dextrin, ethanol and water into dry extract powder, mixing, and making into soft material; making soft material into granule by swing type granulator, boiling and drying, sieving dry granule, grading, and mixing;

and (6) taking the granules, and subpackaging to obtain the traditional Chinese medicine composition.

9. The use of the pharmaceutical composition of claim 1, for the preparation of a medicament for the treatment of wind-heat dry cough.

10. Use of a formulation according to claim 2 in the manufacture of a medicament for the treatment of wind-heat dry cough.