CN115804741A - Anti-aging active composition for promoting absorption and preparation method and application thereof - Google Patents
Anti-aging active composition for promoting absorption and preparation method and application thereof Download PDFInfo
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Abstract
The invention relates to an anti-aging active composition for promoting absorption and a preparation method and application thereof, belonging to the technical field of active composition preparation. The invention adopts the compatibility principle of monarch, minister, assistant and guide medicines, the compositions play a role in synergy, and rhodiola rosea and bighead atractylodes rhizome are used as main components of the monarch medicine composition, so that the anti-aging effect is achieved; the white atractylodes rhizome extract, the liquorice extract and the white poria extract are added to have synergistic effect, so that the immune function is enhanced, and the antibacterial effect is achieved; the chamomile extract, the horsetail extract and the horse chestnut extract are added, and the effects of monarch, minister and adjuvant are assisted, so that the skin absorption is promoted, the skin activity is enhanced, and the skin barrier is repaired. Enzymolysis treatment and ethanol extraction are adopted in the preparation of the monarch drug composition, and multiple times of concentration extraction are adopted in the extraction of the ministerial drug composition, so that the purity and the yield of the obtained product are improved.
Description
Technical Field
The invention belongs to the technical field of active composition preparation, and particularly relates to an anti-aging active composition for promoting absorption and a preparation method and application thereof.
Background
Aging is a natural life process, is the result of the combined action of a plurality of factors inside and outside the body, and is an aging phenomenon caused by natural factors or non-natural factors. After birth, the skin tissue of a person is developed increasingly, the function of the person is active gradually, and the person starts to degenerate when the person reaches a certain age, and the degeneration is gradually performed unconsciously. In recent years, with the increasing standards of people on self image, health and aesthetic, more and more people begin to pay attention to the problem of skin aging, so that the selection of proper beauty skin care products becomes the first choice for people to resist skin aging. However, in order to seek fast and direct effects, most skin care products directly adopt different chemicals as additives to produce skin care products, and because certain side effects exist in the chemicals to further damage the skin and the body, certain extracts or extract combinations with good anti-aging activity are sought from the nature to replace the traditional chemicals and are used as the addition components of the skin care products, so that the market trend is gradually increased.
However, in the counter-market, although cosmetics with natural products or plant extracts as additives are available, the cosmetics are mostly prepared by simply combining plant extracts in a single flavor, and the obtained components and effects are single and are difficult to meet the increasing demands of people, so that the development of an active composition which passes through the natural products or the plant extracts and can realize multiple effects has certain economic and social significance.
Disclosure of Invention
The invention aims to provide an anti-aging active composition for promoting absorption and a preparation method and application thereof, the invention adopts the compatibility principle of monarch, minister, assistant and guide medicines, the compositions play a role in synergy, and rhodiola rosea and bighead atractylodes rhizome are used as main components of the monarch medicine composition, so that the anti-aging active composition has the effect of delaying aging; the white atractylodes rhizome extract, the liquorice extract and the white poria extract are added to have synergistic effect, so that the immune function is enhanced, and the antibacterial effect is achieved; the chamomile extract, the horsetail extract and the horse chestnut extract are added, and the effects of monarch, minister and adjuvant are assisted, so that the skin absorption is promoted, the skin activity is enhanced, and the skin barrier is repaired. Enzymolysis treatment and ethanol extraction are adopted in the preparation of the monarch drug composition, and multiple times of concentration extraction are adopted in the extraction of the ministerial drug composition, so that the purity and the yield of the obtained product are improved.
The technical problems to be solved by the invention are as follows: an anti-aging active composition which takes natural plant extracts as main materials and promotes absorption is developed.
The purpose of the invention can be realized by the following technical scheme:
an anti-aging active composition for promoting absorption comprises the following raw materials in parts by weight:
the monarch drug composition is prepared from rhodiola root and rhizome raw materials and bighead atractylodes rhizome and rhizome raw materials;
the ministerial composition comprises ginseng extract and licorice extract;
the adjuvant composition comprises lotus seed extract, coix seed extract and honey;
the messenger composition comprises chamomile extract, horsetail herb extract and horse chestnut extract.
The rhodiola rosea is a perennial herb plant, the main components of the rhodiola rosea are salidroside, tyrosol, ketone and the like, the rhodiola rosea has stimulation effect on the division and proliferation of fibroblasts in the dermis layer of the skin, can promote the division of the fibroblasts, the synthesis and the secretion of collagen, simultaneously stimulate the cells to secrete collagenase, decompose the original collagen, and form collagen fibers outside the cells, so the rhodiola rosea can increase the amount of the collagen fibers and has strong anti-aging effect, the external preparation consisting of the rhodiola rosea and ginseng can increase the collagen content in the skin, the aging bridges among the collagen are reduced, and the skin is fine, smooth and elastic.
Atractylodes macrocephala koidz is the rhizome of perennial herb Atractylodes macrocephala koidz of Compositae, and belongs to tonifying medicinal materials. The main chemical components of the atractylodes macrocephala koidz comprise volatile oil, atractylenolide, polysaccharide, amino acid and the like, and the atractylodes macrocephala koidz has wide play effect and has the effects of regulating immune function, resisting oxidation, reducing blood sugar, resisting inflammation and the like.
The ginseng contains various ginsenosides, amino acids, vitamins and mineral substances, has the functions of promoting the blood circulation of subcutaneous capillaries, strengthening the cell vitality and promoting the collagen vitality, can effectively delay aging, has good permeability, can deeply moisten the skin, nourish the skin and quickly regulate the moisture balance of the skin.
The Glycyrrhrizae radix is also called Mesona, mesona and Guochao, and is dried root and rhizome of Glycyrrhiza uralensis Fisch, glycyrrhiza inflata Bat or Glycyrrhiza glabra L of Leguminosae. The glycyrrhizin extracted from Glycyrrhrizae radix can regulate skin immunity, enhance skin disease resistance, eliminate inflammation, prevent allergy, clean skin, relieve adverse reaction of cosmetics and other external factors on skin, maintain emulsified state of the product for a long time, and prevent oxidative deterioration.
Poria is fungus belonging to Poria of Polyporaceae, and has mild property, tonifying but not drastic, benefiting but not violent, and no allergic reaction. The tuckahoe powder is added with proper honey and stirred into paste to be applied to the face, and the effects of nourishing skin, eliminating senile plaque and chloasma and lightening spots can be achieved; the tuckahoe powder, some lotus seed powder and almond powder can also be mixed together and applied on the face, thus playing the roles of smoothing the skin and delaying senility.
Further, the anti-aging active composition for promoting absorption further comprises a white poria extract; the adjuvant composition also comprises almond powder.
Further, the monarch drug composition is prepared from the following components in a mass ratio of 2.4-4.1:2-3 of rhodiola root and rhizome raw materials and bighead atractylodes rhizome raw materials; the ministerial drug composition is prepared from ginseng extract, liquorice extract and chinaroot greenbrier rhizome extract according to the mass ratio of 3-6.2:5.4-8: 3.5-5.2; the adjuvant drug composition is prepared from lotus seed extract, coix seed extract, honey and almond powder according to the mass ratio of 3.1-5:4.4-6.3:3-5.2: 2-4; the messenger drug composition is prepared from chamomile extract, horsetail extract and horse chestnut extract according to the mass ratio of 5.4-6.1:1.1-3: 2-3.5.
Further, the preparation steps of the monarch drug composition are as follows:
(1) Preparing raw materials: weighing raw materials of rhodiola rosea rhizome and bighead atractylodes rhizome, crushing by 40-60 meshes, adding purified water which is 1-2 times of the weight of the raw materials of rhodiola rosea rhizome and bighead atractylodes rhizome, soaking for 2h, and heating and boiling for 1-1.5h to obtain a treated material;
(2) Enzymolysis: adding mixed enzyme into the treated material prepared in the step (1), and carrying out enzymolysis for 6-10h under the auxiliary action of ultrasonic waves at the temperature of 40-55 ℃ to obtain an enzymolysis liquid;
(3) Extraction: adding an ethanol solution with the mass concentration of 70 percent which is 6-8 times of the weight of the enzymolysis liquid into the enzymolysis liquid prepared in the step (2), and performing reflux extraction for 2-6 times, 40-80min each time to obtain an extracting solution;
(4) And (4) centrifuging the extracting solution prepared in the step (3), filtering the extracting solution by using bolting silk after centrifugation to obtain a screened solution, distilling the screened solution under reduced pressure, and drying to obtain the monarch drug composition.
Further, the mixed enzyme in the step (2) is cellulase and pectinase according to the mass ratio of 1-2:1 and mixing.
Further, in the step (4), the centrifugal rotating speed is 1800-2000r/min, the centrifugation is 5-6min, and the bolting silk is 400 meshes; reduced pressure distillation is beneficial to removing ethanol in the system, so that the product purity is higher.
Further, the preparation steps of the ginseng extract are as follows:
weighing ginseng raw materials, crushing according to 80-100 meshes, adding purified water with the weight being 10-12 times that of the ginseng raw materials, soaking for 2 hours, heating and boiling for 1-3 hours, filtering by using 4 layers of gauze, collecting filtrate, heating and boiling the filtrate for 1-2 hours, filtering by using 5 layers of gauze, collecting thick liquid, concentrating the thick liquid, drying in vacuum at 65-70 ℃ after the concentration is finished, and obtaining a ginseng extract after the complete drying;
the preparation method of the licorice extract and the white poria extract is the same as that of the ginseng extract.
Further, the preparation method of the anti-aging active composition for promoting absorption comprises the following steps: mixing the monarch drug composition, ministerial drug composition, adjuvant drug composition and messenger drug composition at room temperature, and stirring.
Further, the application of the anti-aging active composition for promoting absorption comprises the preparation of medicines or skin care products, and in the preparation of the skin care products, the anti-aging active composition for promoting absorption accounts for 3.5-8.9% of the total mass of the skin care products.
The invention has the beneficial effects that:
(1) The monarch, minister, assistant and guide formula compatibility principle is adopted, the monarch, minister, assistant and guide compositions are selected to play a role in synergy, the rhodiola rosea and the rhizoma atractylodis macrocephalae are used as main components of the monarch and guide compositions and are matched with ginseng components of the minister and guide compositions, and the ginseng in the minister and the rhodiola rosea form an external preparation which can increase the collagen content in skin, reduce aging bridges among the collagen, has the effect of delaying aging and enables the anti-aging effect to be obviously visible.
(2) The white atractylodes rhizome extract, the liquorice extract and the white poria extract are added to achieve synergistic effect, the liquorice and the white poria auxiliary white atractylodes rhizome can enhance the immune function and regulate the immune function of skin, further enhance the disease resistance of the skin, eliminate inflammation, prevent allergy and clean the skin, and the liquorice and the white poria auxiliary white atractylodes rhizome can enhance the immune function and have an outstanding antibacterial effect.
(3) According to the technical scheme provided by the invention, the chamomile extract is rich in flavonoid active ingredients, and the ingredients have the effects of resisting oxidation, resisting vascular proliferation, diminishing inflammation and resisting viruses, so that chamomile is taken as a composition ingredient and introduced into a skin care product to have the effects of tendering skin, moisturizing, removing acne and the like, the horsetail weed extract has the effects of astringing and promoting and strengthening the skin function, the horse chestnut extract can activate blood, promote absorption and enhance the skin activity, the three components have synergistic effects, and the effects of monarch, minister and adjuvant drugs are supplemented to promote skin absorption and play a role in enhancing the skin activity, prevent and resist dermatitis and repair the barrier function of skin.
(4) The invention adopts enzymolysis treatment and ethanol extraction in the preparation of monarch drug composition, and adopts multiple concentration extraction in the extraction of ginseng extract, licorice extract and chinaroot greenbrier rhizome extract, thereby improving the purity and product yield of the obtained composition and extract.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The monarch drug composition is prepared by the following steps:
(1) Preparing raw materials: weighing the components in a mass ratio of 2.4:3, crushing the rhodiola root stem raw material and the bighead atractylodes rhizome raw material by 50 meshes, adding purified water which is 1 time of the weight of the rhodiola root stem raw material and the bighead atractylodes rhizome raw material, soaking for 2 hours, and heating and boiling for 1 hour to obtain a treated material;
(2) Enzymolysis: adding a processing material prepared in the step (1) into a mixture with the mass ratio of 1:1, performing enzymolysis for 8 hours at the temperature of 55 ℃ under the auxiliary action of ultrasonic waves to obtain an enzymolysis solution;
(3) Extraction: adding 70% ethanol with the mass concentration of 8 times the weight of the enzymolysis liquid into the enzymolysis liquid prepared in the step (2), and performing reflux extraction for 6 times, 40min each time to obtain an extracting solution;
(4) Centrifuging the extracting solution prepared in the step (3) for 5min at the rotation speed of 1900r/min, filtering with 400-mesh bolting silk after centrifugation to obtain a screened solution, distilling the screened solution under reduced pressure to remove ethanol, and drying to obtain the monarch drug composition.
Example 2
The monarch drug composition is prepared by the following steps:
(1) Preparing raw materials: weighing the components in a mass ratio of 3.3:2, crushing the rhodiola root stem raw material and the bighead atractylodes rhizome raw material by a 50-mesh sieve, adding purified water which is 1 time of the weight of the rhodiola root stem raw material and the bighead atractylodes rhizome raw material, soaking for 2 hours, and heating and boiling for 1 hour to obtain a treated material;
(2) Enzymolysis: adding the processing material prepared in the step (1) into a mixture with the mass ratio of 2:1, performing enzymolysis on the mixed enzyme of cellulase and pectinase for 6 hours at the temperature of 40 ℃ under the auxiliary action of ultrasonic waves to obtain an enzymolysis solution;
(3) Extraction: adding 70% ethanol with a mass concentration of 8 times of the weight of the enzymolysis liquid into the enzymolysis liquid prepared in the step (2), and performing reflux extraction for 60min for 2 times to obtain an extracting solution each time;
(4) And (4) centrifuging the extracting solution prepared in the step (3) at the rotating speed of 1900r/min for 5min, filtering the extracting solution by using 400-mesh bolting silk after centrifugation to obtain a screened solution, distilling the screened solution under reduced pressure to remove ethanol, and drying to obtain the monarch drug composition.
Example 3
The monarch drug composition is prepared by the following steps:
(1) Preparing raw materials: weighing the components in a mass ratio of 4.1:2.6 grinding the raw materials of the root and the stem of the rhodiola rosea and the rhizome of the bighead atractylodes rhizome into 50 meshes, adding purified water which is 2 times of the weight of the raw materials of the root and the stem of the rhodiola rosea and the rhizome of the bighead atractylodes rhizome, soaking for 2 hours, and heating and boiling for 1 hour to obtain a treated material;
(2) Enzymolysis: adding the processing material prepared in the step (1) into a mixture with the mass ratio of 1:1, performing enzymolysis on the mixed enzyme of cellulase and pectinase for 10 hours at the temperature of 48 ℃ under the auxiliary action of ultrasonic waves to obtain an enzymolysis liquid;
(3) Extraction: adding 70% ethanol with the mass concentration 6 times of the weight of the enzymolysis liquid into the enzymolysis liquid prepared in the step (2), and performing reflux extraction for 4 times, each time for 80min to obtain an extracting solution;
(4) And (4) centrifuging the extracting solution prepared in the step (3) at the rotating speed of 1900r/min for 5min, filtering the extracting solution by using 400-mesh bolting silk after centrifugation to obtain a screened solution, distilling the screened solution under reduced pressure to remove ethanol, and drying to obtain the monarch drug composition.
Example 4
The preparation method of the ginseng extract comprises the following specific steps:
weighing ginseng raw materials, crushing according to 100 meshes, adding purified water which is 10 times of the weight of the ginseng raw materials, soaking for 2h, heating and boiling for 3h, filtering by using 4 layers of gauze, collecting filtrate, heating and boiling the filtrate for 1h, filtering by using 5 layers of gauze, collecting thick liquid, concentrating the thick liquid, drying in vacuum at 65 ℃ after the concentration is finished, and obtaining the ginseng extract after the complete drying.
The Glycyrrhrizae radix extract and Poria extract are prepared by the same method as Ginseng radix extract.
Example 5
An anti-aging active composition for promoting absorption comprises the following raw materials in parts by weight:
the monarch drug composition is the monarch drug composition prepared in the embodiment 3;
the ministerial drug composition is prepared from ginseng extract and licorice extract prepared by the steps of example 4 according to the mass ratio of 3:8, preparing a mixture;
the adjuvant drug composition is prepared from a lotus seed extract, a coix seed extract and honey according to a mass ratio of 5:5.4:3, preparing a composition;
the messenger drug composition is prepared from chamomile extract, horsetail herb extract and horse chestnut extract according to the mass ratio of 5.8:2: 3.5.
Example 6
An anti-aging active composition for promoting absorption comprises the following raw materials in parts by weight:
the monarch drug composition is the monarch drug composition prepared in the embodiment 3;
the ministerial drug composition is prepared from the ginseng extract and the liquorice extract prepared in the step of example 4 according to the mass ratio of 3: 5.4;
the adjuvant drug composition is prepared from a lotus seed extract, a coix seed extract and honey according to a mass ratio of 3.1:4.4: 5.2;
the messenger drug composition is prepared from chamomile extract, horsetail extract and horse chestnut extract according to the mass ratio of 6.1:2: 2.
Example 7
An anti-aging active composition for promoting absorption comprises the following raw materials in parts by weight:
the monarch drug composition is the monarch drug composition prepared in the embodiment 3;
the ministerial drug composition is prepared from ginseng extract and licorice extract prepared by the steps of example 4 according to the mass ratio of 6.2: 6.7;
the adjuvant drug composition is prepared from lotus seed extract, coix seed extract and honey according to the mass ratio of 3.1-5:5:6.3: 4.2;
the messenger drug composition is prepared from chamomile extract, horsetail extract and horse chestnut extract according to a mass ratio of 5.4:1.1: 3.5.
Example 8
An anti-aging active composition for promoting absorption comprises the following raw materials in parts by weight:
the monarch drug composition is the monarch drug composition prepared in the embodiment 3;
the ministerial drug composition is prepared from ginseng extract, liquorice extract and chinaroot greenbrier rhizome extract prepared in the step of example 4 according to the mass ratio of 3:5.4: 5.2;
the adjuvant drug composition is prepared from a lotus seed extract, a coix seed extract, honey and almond powder according to a mass ratio of 5:5.4:3:2, preparing a composition;
the messenger drug composition is prepared from chamomile extract, horsetail extract and horse chestnut extract according to a mass ratio of 5.4:3: 2.8.
Example 9
An anti-aging active composition for promoting absorption comprises the following raw materials in parts by weight:
the monarch drug composition is the monarch drug composition prepared in the embodiment 3;
the ministerial drug composition is prepared from ginseng extract, liquorice extract and chinaroot greenbrier rhizome extract prepared in the step of example 4 according to the mass ratio of 6.2:8: 5.2;
the adjuvant drug composition is prepared from a lotus seed extract, a coix seed extract, honey and almond powder according to a mass ratio of 3.1:5.4:3:2, preparing a composition;
the messenger drug composition is prepared from chamomile extract, horsetail extract and horse chestnut extract according to a mass ratio of 5.4:3:2.
Example 10
An anti-aging active composition for promoting absorption comprises the following raw materials in parts by weight:
the monarch drug composition is the monarch drug composition prepared in the embodiment 3;
the ministerial drug composition is prepared from ginseng extract, licorice extract and poria cocos wolf extract prepared by the steps of example 4 according to the mass ratio of 3:6.7: 3.5;
the adjuvant drug composition is prepared from a lotus seed extract, a coix seed extract, honey and almond powder according to a mass ratio of 4:4.4:5.2:4, preparing a mixture;
the messenger drug composition is prepared from chamomile extract, horsetail herb extract and horse chestnut extract according to the mass ratio of 5.8:3: 2.8.
Example 11
A method for preparing an anti-aging active composition for promoting absorption, comprising the steps of:
the monarch drug composition, the ministerial drug composition, the adjuvant drug composition and the messenger drug composition are weighed according to the formula of the embodiment 10, mixed and stirred uniformly at normal temperature to obtain the anti-aging active composition for promoting absorption.
Example 12
The anti-aging active composition for promoting absorption prepared in example 11 was used to prepare a drug or a skin care product, and it accounted for 6.2% of the total mass of the skin care product.
Comparative example 1
An anti-aging active composition for promoting absorption comprises the following raw materials in parts by weight:
the monarch drug composition is prepared from the ginseng extract, the liquorice extract and the white poria extract which are prepared in the step of example 4 according to the mass ratio of 3:6.7: 3.5;
the ministerial drug composition is the monarch drug composition prepared in example 3;
the adjuvant drug composition is prepared from a lotus seed extract, a coix seed extract, honey and almond powder according to a mass ratio of 4:4.4:5.2:4, preparing a composition;
the messenger drug composition is prepared from chamomile extract, horsetail extract and horse chestnut extract according to the mass ratio of 5.8:3: 2.8.
Comparative example 2
An anti-aging active composition for promoting absorption comprises the following raw materials in parts by weight:
the monarch drug composition is prepared from lotus seed extract, coix seed extract, honey and almond powder according to a mass ratio of 4:4.4:5.2:4, preparing a composition;
the ministerial drug composition is prepared from ginseng extract, liquorice extract and chinaroot greenbrier rhizome extract prepared in the step of example 4 according to the mass ratio of 3:6.7: 3.5;
the adjuvant drug composition is the monarch drug composition prepared in the example 3;
the messenger drug composition is prepared from chamomile extract, horsetail extract and horse chestnut extract according to the mass ratio of 5.8:3: 2.8.
Comparative example 3
An anti-aging active composition for promoting absorption comprises the following raw materials in parts by weight:
the monarch drug composition is prepared from chamomile extract, horsetail herb extract and horse chestnut extract according to the mass ratio of 5.8:3: 2.8;
the ministerial drug composition is prepared from ginseng extract, liquorice extract and chinaroot greenbrier rhizome extract prepared in the step of example 4 according to the mass ratio of 3:6.7: 3.5;
the adjuvant drug composition is prepared from a lotus seed extract, a coix seed extract, honey and almond powder according to a mass ratio of 4:4.4:5.2:4, preparing a mixture;
the messenger drug composition is the monarch drug composition prepared in example 3.
Comparative example 4
The ginseng extract in the ministerial composition of example 10 was replaced with licorice extract, with the remaining content unchanged.
Comparative example 5
The honey in the adjuvant composition of example 10 was replaced with the extract of coix seed, and the other contents were unchanged.
Comparative example 6
The chamomile extract in the chemical composition in example 10 was replaced with horse chestnut extract, and the other contents were unchanged.
Performance detection
(1) And (3) anti-aging test:
120 wrinkled, healthy and undamaged volunteers aged 30-45 years old were selected, randomly divided into 12 groups of 10, and the obtained creams (composition addition amount is 8%) prepared by using the compositions of examples 5-10 and comparative examples 1-6, respectively, were used once a day in the morning and evening for 30 days.
Before and after use, a VISIA skin detector of Meilebao company is adopted to detect and analyze the use effect, and the detected content comprises skin texture, pores and wrinkles. The test results are reported as a percentage and represent a comparative ranking of the skin characteristics of the subjects compared to others of the same race, age, and muscle type.
Thus, the active compositions prepared in examples 5 to 10 of the present invention and comparative examples 1 to 6 were subjected to an anti-aging test, and the results are shown in Table 1.
(2) Skin moisture content test:
the capacitance method is used for measuring the moisture content of the human skin stratum corneum, and is based on the obvious difference of dielectric constants of water and other substances, the capacitance values of the measured skin are different according to the moisture content of the skin stratum corneum, and the parameters can represent the moisture content of the skin.
120 volunteers with skin dryness, dullness, lusterless, vigorous oil and fat, large pores, sensitivity, red blood streak and pigmentation problems in 30-45 years old are randomly divided into 12 groups, and 10 in each group. The volunteers used the creams prepared by adding the compositions of examples 5 to 10 and comparative examples 1 to 6 to the cream base, respectively (the amount of the composition added to the cream is 2%), once in the morning and in the evening each day for 30 days.
Skin hydration was measured on days 0 and 30 using a skin hydration tester CorneometerCM825, and the hydration of the skin before and after the application of the cream was evaluated, and the results are shown in Table 2.
(3) And (3) testing bacteriostatic performance:
the compositions of examples 5 to 10 of the present invention and comparative examples 1 to 6 were tested for their bacteriostatic properties according to GB15979-2002 hygienic Standard for Disposable sanitary articles appendix C4 "dissolution resistance (bacteriostatic test method for Salix inhibiting products":
1) Preparation of bacterial suspension: washing Propionibacterium acnes and Escherichia coli 24h culture with 0.03mol/L phosphate buffer solution to obtain 10 4 -10 6 CFU/mL bacterial suspension.
2) The compositions of examples 5-10 and comparative examples 1-6 were formulated as 0.1% aqueous solutions. Respectively taking 1g of a sample to be tested, adding 0.1mL of the bacterial suspension, uniformly coating and mixing, starting timing, adding 9mL0.03mol/L phosphate buffer solution after 20min, fully and uniformly mixing, taking 3 dilutions, respectively taking 1L, placing in two parallel plates, adding a corresponding culture medium, and culturing for 24h under the anaerobic condition at 36 +/-1 ℃ for colony counting. The above experiment was repeated 3 times, taking the average.
The calculation formula of the bacteriostatic rate is as follows: x = (A-B)/A X100%, wherein X is the bacteriostasis rate, A is the average recovered colony of the control sample, and B is the average recovered colony of the test sample.
The evaluation standard of the acne removing efficacy is as follows: (1) the bacteriostatic rate is more than or equal to 90 percent and the effect is obvious: (2) the bacteriostasis rate is 50-90 percent: and (3) the bacteriostasis rate is less than 50 percent, which is ineffective.
TABLE 1
TABLE 2
TABLE 3
As can be seen from table 1, after using the cream with the active composition prepared according to the present invention for 30 days, the skin texture, pores and wrinkles are significantly improved, indicating that the active composition according to the present invention has excellent anti-aging properties. In detail, the cream added with the active composition prepared in the embodiment 10 of the invention is respectively increased by 20.59%, 14.81% and 19.20% in the indexes of skin texture, pores and wrinkles after being used compared with the former cream, the increased percentage of the three is far higher than the increased percentage of all the comparative examples, the effective compatibility principle of the monarch, minister, assistant and guide prescription adopted by the invention is reflected, the selected monarch, minister, assistant and guide compositions play a role in synergy, rhodiola rosea and bighead atractylodes rhizome are used as main components of the monarch drug composition, and the ginseng, liquorice and chinaroot greenbrier rhizome of the minister drug composition are matched, so that the lasting skin texture and wrinkles can be effectively lightened, the pore condition is improved, and the anti-aging effect is obviously seen.
As can be seen from table 2, the increase rate of the moisture content of the skin is significantly increased after the cream added with the active composition prepared by the present invention is used for 30 days, which indicates that the active composition prepared by the present invention has a significant absorption promoting function. According to the invention, the coix seed extract is selected as the adjuvant drug composition, the coix seed has permeability and can inject moisture into the skin so as to keep the skin in a moist state, the chamomile extract, the red sage extract and the horse chestnut extract are selected as the messenger drug composition, and the messenger drug composition is used as a blend to be matched with the effects of monarch, minister and adjuvant drugs, so that the skin activity is enhanced, and the skin absorption is promoted.
As can be seen from Table 3, the active composition prepared by the invention has an outstanding antibacterial effect, and due to the synergistic effect of the white atractylodes rhizome extract, the liquorice root extract and the white poria extract, the liquorice root and the white poria assisting the white atractylodes rhizome can enhance the immune function and regulate the immune function of the skin, further enhance the disease resistance of the skin, eliminate inflammation, prevent allergy and clean the skin.
In the description herein, references to the description of "one embodiment," "an example," "a specific example" or the like are intended to mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
The foregoing is illustrative and explanatory only and is not intended to be exhaustive or to limit the invention to the precise embodiments described, and various modifications, additions, and substitutions may be made by those skilled in the art without departing from the scope of the invention or exceeding the scope of the claims.
Claims (10)
1. The anti-aging active composition for promoting absorption is characterized by comprising the following raw materials in parts by weight:
the monarch drug composition is prepared from rhodiola root and rhizome raw materials and bighead atractylodes rhizome and rhizome raw materials;
the ministerial composition comprises ginseng extract and licorice extract;
the adjuvant composition comprises lotus seed extract, coix seed extract and honey;
the messenger drug composition comprises chamomile extract, horsetail extract and horse chestnut extract.
2. The absorption enhancing, antiaging composition according to claim 1, wherein said ministerial composition further comprises Poria cocos wolf extract; the adjuvant composition also comprises almond powder.
3. The composition with anti-aging activity for promoting absorption according to claim 2, characterized in that the mass ratio of the monarch drug composition is 2.4-4.1:2-3 of rhodiola root and rhizome raw materials and bighead atractylodes rhizome raw materials; the ministerial drug composition is prepared from ginseng extract, liquorice extract and chinaroot greenbrier rhizome extract according to the mass ratio of 3-6.2:5.4-8: 3.5-5.2.
4. The composition with anti-aging activity for promoting absorption according to claim 2, wherein the adjuvant composition is prepared from lotus seed extract, coix seed extract, honey and almond powder according to the mass ratio of 3.1-5:4.4-6.3:3-5.2: 2-4.
5. The absorption-promoting antiaging active composition as claimed in claim 1, wherein the messenger composition is prepared from chamomile extract, horsetail grass extract and horse chestnut extract at a mass ratio of 5.4-6.1:1.1-3: 2-3.5.
6. The composition with anti-aging activity for promoting absorption according to claim 1, wherein the preparation steps of the monarch drug composition are as follows:
(1) Preparing raw materials: weighing rhodiola root and rhizome raw materials and bighead atractylodes rhizome raw materials, crushing according to 40-60 meshes, adding purified water which is 1-2 times the weight of the rhodiola root and rhizome raw materials and the weight of the bighead atractylodes rhizome raw materials, soaking for 2 hours, and heating and boiling for 1-1.5 hours to obtain a treated material;
(2) Enzymolysis: adding mixed enzyme into the treated material prepared in the step (1), and carrying out enzymolysis for 6-10h under the auxiliary action of ultrasonic waves at the temperature of 40-55 ℃ to obtain an enzymolysis liquid;
(3) Extraction: adding 70% ethanol solution 6-8 times the weight of the enzymolysis solution into the enzymolysis solution obtained in step (2), reflux extracting for 2-6 times, each time for 40-80min to obtain extractive solution;
(4) And (4) centrifuging the extracting solution prepared in the step (3), filtering by using a bolting silk after centrifugation to obtain a screened solution, and distilling the screened solution under reduced pressure and drying to obtain the monarch drug composition.
7. The composition for promoting absorption and resisting ageing activity according to claim 6, wherein the mixed enzyme in step (2) is cellulase and pectinase in a mass ratio of 1-2:1, mixing; in the step (4), the centrifugal rotating speed is 1800-2000r/min, the centrifugation is 5-6min, and the bolting silk is 400 meshes.
8. The composition of claim 2, wherein the ginseng extract is prepared by the steps of:
weighing ginseng raw materials, crushing according to 80-100 meshes, adding purified water with the weight being 10-12 times of that of the ginseng raw materials, soaking for 2 hours, heating and boiling for 1-3 hours, filtering by using 4 layers of gauze, collecting filtrate, heating and boiling the filtrate for 1-2 hours, filtering by using 5 layers of gauze, collecting thick liquid, concentrating the thick liquid, drying in vacuum at 65-70 ℃ after the concentration is finished, and obtaining a ginseng extract after the complete drying;
the preparation method of the licorice extract and the white poria extract is the same as that of the ginseng extract.
9. A method for preparing an absorption-promoting antiaging active composition according to any one of claims 1-8, characterized in that the preparation method comprises the steps of: mixing the monarch drug composition, ministerial drug composition, adjuvant drug composition and messenger drug composition at room temperature, and stirring.
10. Use of the absorption enhancing anti-ageing active composition according to any one of claims 1 to 8, in the manufacture of a medicament or a skin care product, wherein the absorption enhancing anti-ageing active composition is present in an amount of from 3.5 to 8.9% by weight of the total skin care product.
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Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002241299A (en) * | 2001-02-13 | 2002-08-28 | Ichimaru Pharcos Co Ltd | Maillard reaction recovering agent |
| CN102302440A (en) * | 2011-09-23 | 2012-01-04 | 孙丽华 | Chinese medicinal herb softening, whitening, anti-aging, wrinkle-smoothing and freckle-removing cosmetic composition |
| CN102641228A (en) * | 2012-05-18 | 2012-08-22 | 通德集团有限公司 | Rhodiola crenulata eye cream with whitening and anti-wrinkle effects |
| CN107308440A (en) * | 2017-06-01 | 2017-11-03 | 李博 | Dispel striae of pregnancy, scar reparation, anti-wrinkle Skin whitening care cosmeticses and preparation method thereof |
| CN107898749A (en) * | 2017-12-29 | 2018-04-13 | 成都辅正生物科技有限公司 | A kind of topical composition with skin-care effect and preparation method thereof |
| CN108042476A (en) * | 2018-02-01 | 2018-05-18 | 广州鹰远生物科技有限公司 | A kind of lotion containing Flos persicae extract |
| CN108125881A (en) * | 2018-02-01 | 2018-06-08 | 广东芭薇生物科技股份有限公司 | A kind of anti-apolexis composition and its application containing Flos persicae extract |
| CN110664679A (en) * | 2019-10-15 | 2020-01-10 | 广州环亚化妆品科技有限公司 | Traditional Chinese medicine composition with whitening and anti-aging effects and preparation method and application thereof |
| CN113694001A (en) * | 2020-05-21 | 2021-11-26 | 付天宇 | Traditional Chinese medicine mask paste |
| US20220087926A1 (en) * | 2020-09-24 | 2022-03-24 | Chenland Nutritionals Inc. | Compound composition with anti-oxidation and anti-aging effects and preparation method and application thereof |
| CN114617803A (en) * | 2022-03-22 | 2022-06-14 | 王新伟 | Pure natural medical mineral water and traditional Chinese medicine composition |
-
2022
- 2022-12-10 CN CN202211586338.0A patent/CN115804741B/en active Active
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002241299A (en) * | 2001-02-13 | 2002-08-28 | Ichimaru Pharcos Co Ltd | Maillard reaction recovering agent |
| CN102302440A (en) * | 2011-09-23 | 2012-01-04 | 孙丽华 | Chinese medicinal herb softening, whitening, anti-aging, wrinkle-smoothing and freckle-removing cosmetic composition |
| CN102641228A (en) * | 2012-05-18 | 2012-08-22 | 通德集团有限公司 | Rhodiola crenulata eye cream with whitening and anti-wrinkle effects |
| CN107308440A (en) * | 2017-06-01 | 2017-11-03 | 李博 | Dispel striae of pregnancy, scar reparation, anti-wrinkle Skin whitening care cosmeticses and preparation method thereof |
| CN107898749A (en) * | 2017-12-29 | 2018-04-13 | 成都辅正生物科技有限公司 | A kind of topical composition with skin-care effect and preparation method thereof |
| CN108042476A (en) * | 2018-02-01 | 2018-05-18 | 广州鹰远生物科技有限公司 | A kind of lotion containing Flos persicae extract |
| CN108125881A (en) * | 2018-02-01 | 2018-06-08 | 广东芭薇生物科技股份有限公司 | A kind of anti-apolexis composition and its application containing Flos persicae extract |
| CN110664679A (en) * | 2019-10-15 | 2020-01-10 | 广州环亚化妆品科技有限公司 | Traditional Chinese medicine composition with whitening and anti-aging effects and preparation method and application thereof |
| CN113694001A (en) * | 2020-05-21 | 2021-11-26 | 付天宇 | Traditional Chinese medicine mask paste |
| US20220087926A1 (en) * | 2020-09-24 | 2022-03-24 | Chenland Nutritionals Inc. | Compound composition with anti-oxidation and anti-aging effects and preparation method and application thereof |
| CN114617803A (en) * | 2022-03-22 | 2022-06-14 | 王新伟 | Pure natural medical mineral water and traditional Chinese medicine composition |
Non-Patent Citations (1)
| Title |
|---|
| 董银卯等: "化妆品植物组方功效原料的研发思路", 日用化学品科学, vol. 40, no. 09, pages 1 - 3 * |
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