CN115778869A - Skin care product containing supramolecular zinc oxide and preparation method thereof - Google Patents
Skin care product containing supramolecular zinc oxide and preparation method thereof Download PDFInfo
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- CN115778869A CN115778869A CN202211407357.2A CN202211407357A CN115778869A CN 115778869 A CN115778869 A CN 115778869A CN 202211407357 A CN202211407357 A CN 202211407357A CN 115778869 A CN115778869 A CN 115778869A
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- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 title claims abstract description 175
- 239000011787 zinc oxide Substances 0.000 title claims abstract description 88
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims abstract description 62
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 39
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims abstract description 38
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims abstract description 31
- 229940032094 squalane Drugs 0.000 claims abstract description 31
- 239000001100 (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one Substances 0.000 claims abstract description 25
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 25
- QUQPHWDTPGMPEX-UHFFFAOYSA-N Hesperidine Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(OC3C(C(O)C(O)C(COC4C(C(O)C(O)C(C)O4)O)O3)O)=CC(O)=C2C(=O)C1 QUQPHWDTPGMPEX-UHFFFAOYSA-N 0.000 claims abstract description 25
- QUQPHWDTPGMPEX-UTWYECKDSA-N aurantiamarin Natural products COc1ccc(cc1O)[C@H]1CC(=O)c2c(O)cc(O[C@@H]3O[C@H](CO[C@@H]4O[C@@H](C)[C@H](O)[C@@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@H]3O)cc2O1 QUQPHWDTPGMPEX-UTWYECKDSA-N 0.000 claims abstract description 25
- APSNPMVGBGZYAJ-GLOOOPAXSA-N clematine Natural products COc1cc(ccc1O)[C@@H]2CC(=O)c3c(O)cc(O[C@@H]4O[C@H](CO[C@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@H]4O)cc3O2 APSNPMVGBGZYAJ-GLOOOPAXSA-N 0.000 claims abstract description 25
- VUYDGVRIQRPHFX-UHFFFAOYSA-N hesperidin Natural products COc1cc(ccc1O)C2CC(=O)c3c(O)cc(OC4OC(COC5OC(O)C(O)C(O)C5O)C(O)C(O)C4O)cc3O2 VUYDGVRIQRPHFX-UHFFFAOYSA-N 0.000 claims abstract description 25
- QUQPHWDTPGMPEX-QJBIFVCTSA-N hesperidin Chemical compound C1=C(O)C(OC)=CC=C1[C@H]1OC2=CC(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@H]4[C@@H]([C@H](O)[C@@H](O)[C@H](C)O4)O)O3)O)=CC(O)=C2C(=O)C1 QUQPHWDTPGMPEX-QJBIFVCTSA-N 0.000 claims abstract description 25
- 229940025878 hesperidin Drugs 0.000 claims abstract description 25
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 25
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 25
- ARGKVCXINMKCAZ-UHFFFAOYSA-N neohesperidine Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(OC3C(C(O)C(O)C(CO)O3)OC3C(C(O)C(O)C(C)O3)O)=CC(O)=C2C(=O)C1 ARGKVCXINMKCAZ-UHFFFAOYSA-N 0.000 claims abstract description 25
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims abstract description 22
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 claims abstract description 22
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims abstract description 22
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims abstract description 22
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 claims abstract description 22
- 229940114124 ferulic acid Drugs 0.000 claims abstract description 22
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 claims abstract description 22
- 235000001785 ferulic acid Nutrition 0.000 claims abstract description 22
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 claims abstract description 22
- 239000000419 plant extract Substances 0.000 claims abstract description 20
- 244000144725 Amygdalus communis Species 0.000 claims abstract description 19
- 235000011437 Amygdalus communis Nutrition 0.000 claims abstract description 19
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims abstract description 19
- 239000008168 almond oil Substances 0.000 claims abstract description 19
- 235000019437 butane-1,3-diol Nutrition 0.000 claims abstract description 19
- CKQVRZJOMJRTOY-UHFFFAOYSA-N octadecanoic acid;propane-1,2,3-triol Chemical compound OCC(O)CO.CCCCCCCCCCCCCCCCCC(O)=O CKQVRZJOMJRTOY-UHFFFAOYSA-N 0.000 claims abstract description 19
- 239000000230 xanthan gum Substances 0.000 claims abstract description 19
- 229920001285 xanthan gum Polymers 0.000 claims abstract description 19
- 229940082509 xanthan gum Drugs 0.000 claims abstract description 19
- 235000010493 xanthan gum Nutrition 0.000 claims abstract description 19
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims abstract description 17
- 239000002994 raw material Substances 0.000 claims abstract description 16
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims abstract description 13
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims abstract description 13
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 7
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 7
- 239000000284 extract Substances 0.000 claims description 21
- 238000010438 heat treatment Methods 0.000 claims description 19
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 15
- 238000001816 cooling Methods 0.000 claims description 14
- 239000003921 oil Substances 0.000 claims description 14
- 235000019198 oils Nutrition 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 12
- 238000006243 chemical reaction Methods 0.000 claims description 10
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 9
- 238000002156 mixing Methods 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 6
- 239000000243 solution Substances 0.000 claims description 6
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims description 5
- IIEWJVIFRVWJOD-UHFFFAOYSA-N ethyl cyclohexane Natural products CCC1CCCCC1 IIEWJVIFRVWJOD-UHFFFAOYSA-N 0.000 claims description 5
- 244000303040 Glycyrrhiza glabra Species 0.000 claims description 4
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims description 4
- ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 claims description 4
- 238000000265 homogenisation Methods 0.000 claims description 4
- 230000008569 process Effects 0.000 claims description 4
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- 230000000694 effects Effects 0.000 abstract description 12
- 201000004624 Dermatitis Diseases 0.000 abstract description 11
- 206010061218 Inflammation Diseases 0.000 abstract description 9
- 230000004054 inflammatory process Effects 0.000 abstract description 9
- 230000003467 diminishing effect Effects 0.000 abstract description 8
- 230000001737 promoting effect Effects 0.000 abstract description 6
- 239000002537 cosmetic Substances 0.000 abstract description 5
- 208000010668 atopic eczema Diseases 0.000 abstract description 4
- 230000010261 cell growth Effects 0.000 abstract description 4
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- 230000000474 nursing effect Effects 0.000 abstract 1
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- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 6
- 239000004480 active ingredient Substances 0.000 description 6
- 230000001333 moisturizer Effects 0.000 description 6
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- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 4
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- 235000011477 liquorice Nutrition 0.000 description 3
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- BDOYKFSQFYNPKF-UHFFFAOYSA-N 2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetic acid;sodium Chemical compound [Na].[Na].OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O BDOYKFSQFYNPKF-UHFFFAOYSA-N 0.000 description 2
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- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 description 1
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- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 1
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- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The application provides a skin care product containing supramolecular zinc oxide and a preparation method thereof, and relates to the technical field of cosmetic products. A skin care product containing supramolecular zinc oxide comprises the following raw materials: supramolecular zinc oxide, squalane, sweet almond oil, nicotinamide, trehalose, 1, 3-butanediol, disodium ethylene diamine tetraacetate, hyaluronic acid, xanthan gum, glycerol stearic acid, ferulic acid, hesperidin, plant extract and water. The supermolecule zinc oxide prepared by adopting polyethylene glycol as a surfactant is used as a main functional raw material, and compared with common nano zinc oxide, the supermolecule zinc oxide has a more complex structural form, namely, has a larger specific surface area, so that the supermolecule zinc oxide has a larger area, can absorb ultraviolet light in sunlight, has a more excellent sun-proof effect, has the advantages of diminishing inflammation, promoting wound cell growth and being healthy and safe, and can be suitable for nursing the skin of an infant or treating eczema dermatitis of the infant.
Description
Technical Field
The application relates to the technical field of cosmetic products, in particular to a skin care product containing supramolecular zinc oxide and a preparation method thereof.
Background
Environmental pollution, air deterioration, is a negative consequence of developing countries seeking to gain rapid economic growth. The first barrier of human body, namely the skin, is a serious test, and under the various stresses of environmental change, air pollution, ultraviolet radiation, irregular life and rest, working and living pressure and the like, the skin state is increasingly worse, the problems are increasingly prominent, such as water loss, damaged skin lipid membrane balance, barrier damage and melanosis, and then collagen loss and elasticity loss appear on the dermis, and the skin is increasingly dry, dull, sensitive, loose, reddish, dry lines and fine lines.
However, most of the currently used cosmetics have the problems of unclear effect and certain adverse reaction, and particularly, in order to pursue more functionality, most of the existing skin care products have more chemical products, so that the cosmetics have strong irritation and cannot be used for infants.
Disclosure of Invention
The purpose of the application is to provide a skin care product containing supramolecular zinc oxide, which has the advantages of moisturizing, diminishing inflammation, being safe and promoting the recovery of skin wounds.
Another object of the present application is to provide a process for the preparation of skin care products containing supramolecular zinc oxide, which process is simple and convenient.
The technical problem to be solved by the application is solved by adopting the following technical scheme.
In one aspect, the present application provides a skin care product containing supramolecular zinc oxide, which includes the following raw materials: supramolecular zinc oxide, squalane, sweet almond oil, nicotinamide, trehalose, 1, 3-butanediol, disodium ethylene diamine tetraacetate, hyaluronic acid, xanthan gum, glycerol stearic acid, ferulic acid, hesperidin, plant extract and water.
In another aspect, the present embodiments provide a method of heating and mixing supramolecular zinc oxide, water, xanthan gum, 1,3 butylene glycol, and plant extract to obtain a mixture aqueous phase;
heating, homogenizing and dispersing squalane, sweet almond oil, nicotinamide, trehalose, disodium ethylene diamine tetraacetate, hyaluronic acid, glycerol stearic acid, ferulic acid and hesperidin to obtain an oil phase;
and adding the water phase into the oil phase, homogenizing, cooling to 40-50 ℃, homogenizing again, and cooling to room temperature to obtain the skin care product containing the supramolecular zinc oxide.
Compared with the prior art, the embodiment of the application has at least the following advantages or beneficial effects:
1. the supermolecule zinc oxide prepared by adopting polyethylene glycol as a surfactant is used as a main functional raw material, and has a more complex structural form, namely a larger specific surface area compared with common nano zinc oxide, so that the supermolecule zinc oxide has a larger area and can absorb ultraviolet light in sunlight, and a better sun-screening effect is achieved.
2. This application is collocation squalane on supramolecular zinc oxide's basis, and squalane can be integrated into one body with the skin fat membrane of human body self to form the one deck barrier outside the epidermis especially at the wound, this barrier can pass through the micromolecular substance, prevents the zinc oxide particle simultaneously and gets into, makes to stop on the skin surface, both strengthens the absorption of zinc oxide to the ultraviolet light, can prevent again that zinc oxide from entering into the human body and causing the damage. The skin secretion of infants is small and sensitive, and chemical molecules are blocked outside by adopting a squalane barrier membrane to prevent the skin from absorbing the skin, so that the skin care product can be applied to the infants.
3. The skin moisturizer is added with the raw materials, such as hesperidin, hyaluronic acid, nicotinamide and the like, so that the skin moisturizer can be deeply shrunk and moisturized, the skin barrier can be repaired, and the skin resistance can be improved; trehalose is added as a protective agent of active ingredients such as hyaluronic acid, hesperidin and the like to prevent the active ingredients from being decomposed and improve the storage time of the product; the added ferulic acid, the plant extract and the like and the zinc oxide have the antibacterial and anti-inflammatory effects, can quickly diminish inflammation of wounds, further promote repair of damaged cells by squalane, and particularly have excellent treatment effect on infantile eczema dermatitis.
In conclusion, the skin care product has the advantages of sun screening, inflammation diminishing, wound cell growth promoting, health and safety, and can be suitable for infant skin care or treatment of infant eczema and dermatitis.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below. The examples, in which specific conditions are not specified, were carried out according to conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are conventional products which are not indicated by manufacturers and are commercially available.
It should be noted that, in the present application, the embodiments and features of the embodiments may be combined with each other without conflict. The present application will be described in detail below with reference to specific examples.
A skin care product containing supramolecular zinc oxide, comprising the following raw materials: supramolecular zinc oxide, squalane, sweet almond oil, nicotinamide, trehalose, 1, 3-butanediol, disodium ethylene diamine tetraacetate, hyaluronic acid, xanthan gum, glycerol stearic acid, ferulic acid, hesperidin, plant extract and water.
The research generally considers that the nano zinc oxide has two main mechanisms for shielding ultraviolet rays: firstly, medium-short wave ultraviolet in sunlight is absorbed; scattering long-wave ultraviolet rays; the supermolecule zinc oxide prepared by adopting polyethylene glycol as a surfactant is used as a main functional raw material, and has a more complex structural form, namely a larger specific surface area compared with common nano zinc oxide, so that the supermolecule zinc oxide has a larger area and can absorb ultraviolet light in sunlight, and a better sun-screening effect is achieved.
This application is collocation squalane on supramolecular zinc oxide's basis, and squalane can be integrated into one body with the skin fat membrane of human body self to form the one deck barrier outside the epidermis especially at the wound, this barrier can pass through the micromolecular substance, prevents the zinc oxide particle simultaneously and gets into, makes to stop on the skin surface, both strengthens the absorption of zinc oxide to the ultraviolet light, can prevent again that zinc oxide from entering into the human body and causing the damage. The skin secretion of infants is small and sensitive, and chemical molecules are blocked outside by adopting a squalane barrier membrane to prevent the skin from absorbing the skin, so that the skin care product can be applied to the infants.
The skin moisturizer is added with the raw materials, such as hesperidin, hyaluronic acid, nicotinamide and the like, so that the skin moisturizer can be deeply shrunk and moisturized, the skin barrier can be repaired, and the skin resistance can be improved; trehalose is added as a protective agent of active ingredients such as hyaluronic acid, hesperidin and the like to prevent the active ingredients from being decomposed, so that the storage time of the product is prolonged; the ferulic acid, the plant extract and the like are added, so that the composite has the effects of resisting bacteria and diminishing inflammation, can quickly diminish inflammation of wounds, further promotes the repair of damaged cells by squalane, and particularly has an excellent treatment effect on infantile eczema dermatitis.
In conclusion, the skin care product has the advantages of sun screening, inflammation diminishing, wound cell growth promoting, health and safety, and can be suitable for infant skin care or treatment of infant eczema and dermatitis.
In some embodiments of the present application, the formulation comprises the following raw materials in parts by weight: 5-10 parts of supramolecular zinc oxide, 6-12 parts of squalane, 4-8 parts of sweet almond oil, 1-3 parts of nicotinamide, 1-3 parts of trehalose, 0.5-3 parts of 1, 3-butanediol, 0.5-2 parts of disodium ethylene diamine tetraacetate, 2-5 parts of hyaluronic acid, 1-3 parts of xanthan gum, 0.4-1.5 parts of glycerol stearic acid, 0.6-1.5 parts of ferulic acid, 0.1-1 part of hesperidin, 1-3 parts of plant extract and 60-70 parts of water.
In some embodiments of the present application, the formulation comprises the following raw materials in parts by weight: 8 parts of supramolecular zinc oxide, 8 parts of squalane, 6 parts of sweet almond oil, 2 parts of nicotinamide, 2 parts of trehalose, 1.5 parts of 1, 3-butanediol, 1 part of disodium ethylene diamine tetraacetate, 3 parts of hyaluronic acid, 2 parts of xanthan gum, 1 part of glycerol stearic acid, 1 part of ferulic acid, 0.5 part of hesperidin, 2 parts of plant extract and 62 parts of water.
In some embodiments of the present application, the plant extracts include at least three of a millettia extract, a licorice extract, a centella extract, a viola yedoensis extract, and a mint extract. The extract of Artocarpus heterophyllus has antioxidant effect, and can form protective film on skin surface to achieve long-term water supplementing effect. The Glycyrrhrizae radix extract contains glycyrrhizic acid, and has effects of relieving inflammation and protecting skin wound, and the herba Menthae extract has effects of relieving pain and diminishing inflammation, and can reduce irritation of other materials when the skin care product is used for infant or wound.
In some embodiments of the present application, the supramolecular zinc oxide is prepared by the following steps: mixing ethyl acetate, cyclohexane and water to prepare a reaction system, adjusting the pH value of the reaction system to 9.5-10 by adopting a buffer solution, heating, adding polyethylene glycol, adding a zinc acetate solution, and performing ultrasonic dispersion for 1-2 hours to obtain the supermolecule zinc oxide.
In some embodiments of the present application, the volume ratio of ethyl acetate, cyclohexane and water is 1: (2-3): (5-10), and the temperature after temperature rise is 35-45 ℃.
In some embodiments of the present application, the above-mentioned ethylene glycol is added in a volume of 1/50 of the volume of the reaction system, and the ratio of the volume of the acetic acid to the volume of the reaction system is 1: (10-20).
A method of preparing a skin care product containing supramolecular zinc oxide, comprising the steps of:
heating and mixing supramolecular zinc oxide, water, xanthan gum, 1,3 butanediol and plant extract to obtain a mixture water phase;
heating, homogenizing and dispersing squalane, sweet almond oil, nicotinamide, trehalose, disodium ethylene diamine tetraacetate, hyaluronic acid, glycerol stearic acid, ferulic acid and hesperidin to obtain an oil phase;
adding the water phase into the oil phase, homogenizing, cooling to 40-50 ℃, re-homogenizing, and cooling to room temperature to obtain the skin care product containing the supramolecular zinc oxide.
In some embodiments of the present application, the heating temperature is 70 to 80 ℃.
In some embodiments of the present application, the homogenization rate is 8000-10000r/min, and the time for each homogenization is 10-20min.
The features and properties of the present application are described in further detail below with reference to examples.
The supramolecular zinc oxide adopted in the application is prepared by the following method: ethyl acetate, cyclohexane and water were mixed in a ratio of 1:3:10, adopting phosphate buffer solution to adjust the pH value of the reaction system to 10, heating to 40 ℃, adding polyethylene glycol, adding zinc acetate solution, wherein the adding amount of the ethylene glycol and the zinc acetate solution is 1/50 and 1/20 of the volume of the whole reaction system, performing ultrasonic dispersion on the raw materials for 1.5h, and removing impurities to obtain the supramolecular zinc oxide.
Example 1
A method of preparing a skin care product containing supramolecular zinc oxide, comprising the steps of:
weighing 8g of supramolecular zinc oxide, 8g of squalane, 6g of sweet almond oil, 2g of nicotinamide, 2g of trehalose, 1.5g of 1, 3-butanediol, 1g of disodium ethylenediamine tetraacetic acid, 3g of hyaluronic acid, 2g of xanthan gum, 1g of glycerol stearic acid, 1g of ferulic acid, 0.5g of hesperidin, 1g of melaleuca extract, 0.5g of liquorice extract, 0.5g of centella extract and 62g of water.
Heating supramolecular zinc oxide, water, xanthan gum, 1,3 butanediol and plant extract to 80 ℃, stirring and mixing uniformly to obtain a mixture water phase, and continuously stirring for later use;
heating squalane, sweet almond oil, nicotinamide, trehalose, disodium edetate, hyaluronic acid, glycerol stearic acid, ferulic acid and hesperidin to 80 deg.C, and homogenizing and dispersing at 8000r/min for 15min to obtain oil phase;
slowly adding the water phase into the oil phase, continuing homogenizing for 20min, cooling to 45 ℃, homogenizing again for 10min, and cooling to room temperature to obtain the skin care product containing the supramolecular zinc oxide.
Example 2
A method of making a skin care product containing supramolecular zinc oxide, comprising the steps of:
weighing 10g of supramolecular zinc oxide, 12g of squalane, 4g of sweet almond oil, 1g of nicotinamide, 3g of trehalose, 2g of 1, 3-butanediol, 0.5g of ethylene diamine tetraacetic acid disodium, 2g of hyaluronic acid, 1g of xanthan gum, 0.5g of glycerol stearic acid, 1g of ferulic acid, 0.2g of hesperidin, 0.5g of melaleuca extract, 0.8g of liquorice extract, 0.5g of mint extract and 60g of water.
Heating supramolecular zinc oxide, water, xanthan gum, 1,3 butanediol and plant extract to 75 ℃, stirring and mixing uniformly to obtain a mixture water phase, and continuously stirring for later use;
heating squalane, sweet almond oil, nicotinamide, trehalose, disodium ethylenediaminetetraacetate, hyaluronic acid, glycerol stearic acid, ferulic acid and hesperidin to 75 ℃, and performing uniform dispersion for 18min at a speed of 8500r/min to obtain an oil phase;
slowly adding the water phase into the oil phase, continuing homogenizing for 15min, cooling to 40 ℃, homogenizing again for 10min, and cooling to room temperature to obtain the skin care product containing the supramolecular zinc oxide.
Example 3
A method of preparing a skin care product containing supramolecular zinc oxide, comprising the steps of:
weighing 5g of supramolecular zinc oxide, 8g of squalane, 8g of sweet almond oil, 3g of nicotinamide, 1g of trehalose, 0.5g of 1, 3-butanediol, 2g of disodium ethylene diamine tetraacetate, 5g of hyaluronic acid, 3g of xanthan gum, 1.5g of glycerol stearic acid, 0.6g of ferulic acid, 0.6g of hesperidin, 0.3g of millettia extract, 1g of liquorice extract, 0.2g of mint extract, 0.5g of philippine violet herb extract and 60g of water.
Heating supramolecular zinc oxide, water, xanthan gum, 1,3 butanediol and plant extract to 70 ℃, stirring and mixing uniformly to obtain a mixture water phase, and continuously stirring for later use;
heating squalane, sweet almond oil, nicotinamide, trehalose, disodium edetate, hyaluronic acid, glycerol stearic acid, ferulic acid and hesperidin to 70 ℃, and homogenizing and dispersing at 10000r/min for 15min to obtain an oil phase;
slowly adding the water phase into the oil phase, continuing homogenizing for 10min, cooling to 40 ℃, homogenizing for 10min again, and cooling to room temperature to obtain the skin care product containing the supramolecular zinc oxide.
Example 4
A method of making a skin care product containing supramolecular zinc oxide, comprising the steps of:
weighing 9g of supramolecular zinc oxide, 12g of squalane, 7g of sweet almond oil, 1.5g of nicotinamide, 1.5g of trehalose, 1.2g of 1, 3-butanediol, 1.2g of ethylene diamine tetraacetic acid disodium, 4g of hyaluronic acid, 2.5g of xanthan gum, 1.2g of glycerol stearic acid, 0.8g of ferulic acid, 0.1g of hesperidin, 1g of a millettia extract, 0.2g of a mint extract, 0.3g of a Chinese violet extract and 70g of water.
Heating supramolecular zinc oxide, water, xanthan gum, 1,3 butanediol and plant extract to 70 ℃, stirring and mixing uniformly to obtain a mixture water phase, and continuously stirring for later use;
heating squalane, sweet almond oil, nicotinamide, trehalose, disodium edetate, hyaluronic acid, glycerol stearic acid, ferulic acid and hesperidin to 70 ℃, and homogenizing and dispersing at 9000r/min for 15min to obtain an oil phase;
slowly adding the water phase into the oil phase, continuing homogenizing for 10min, cooling to 40 ℃, homogenizing again for 12min, and cooling to room temperature to obtain the skin care product containing the supramolecular zinc oxide.
Comparative example
This comparative example is substantially the same as example 1, and the details of the same are omitted, except that nano-zinc oxide is used in place of supramolecular zinc oxide in the present application.
Examples of the experiments
1. Irritation test
The skin care products prepared in examples 1 to 4 and comparative example 1 were subjected to a human skin closed patch test according to the method described in section 2 of the seventh method for human safety inspection in the technical Specification for cosmetic safety (2015 edition). The judgment criteria are shown in Table 1, and the test results are shown in Table 2.
TABLE 1
TABLE 2
As can be seen from tables 1 and 2, the skin care products prepared herein are safe and non-irritating to the skin.
2. Test for promoting growth of damaged cells
60 SD rats were prepared and randomly divided into 6 experimental groups of 10 mice each, and each of the groups was divided into 2cm × 2cm test areas on the skin corresponding to the back, where the skin was damaged by 5% SDS lotion by soaking for 1 hour, experimental groups 1 to 4 were each prepared using the skin care products of examples 1 to 4 of the present application, experimental group 5 was prepared using the skin care product of the comparative example, and experimental group 6 was coated with a general medical anti-inflammatory and bactericidal product. Each experimental group is smeared once in the morning and at night every day and then placed in the same experimental environment for recovery, ultraviolet irradiation is kept for 2h every day during the recovery period, the ultraviolet irradiation lasts for 15 days, the hydration action of the wound is tested by using a cutin measurer on the 0 th day, the 3 th day, the 7 th day and the 15 th day respectively, and the higher the hydration value is, the better the damaged skin is repaired. The results are shown in Table 3.
TABLE 3
As can be seen from Table 3, the skin care products prepared in the examples of the present application have anti-inflammatory effects and can promote cell regeneration at wounds. The nano zinc oxide is adopted to replace the supramolecular zinc oxide in the comparative example, the wound healing and moisturizing effects are reduced, and the specific principle of the supramolecular zinc oxide can be subjected to follow-up research.
In summary, the skin care product containing supramolecular zinc oxide and the preparation method thereof provided by the embodiment of the application have the following advantages:
1. the supermolecule zinc oxide prepared by adopting polyethylene glycol as a surfactant is used as a main functional raw material, and has a more complex structural form, namely a larger specific surface area compared with common nano zinc oxide, so that the supermolecule zinc oxide has a larger area and can absorb ultraviolet light in sunlight, and a better sun-screening effect is achieved.
2. This application collocation squalane on supramolecular zinc oxide's basis, squalane can combine together with the skin fat membrane of human body self to form the one deck barrier outside the epidermis especially in the wound, this barrier can pass through the micromolecule material, prevents the zinc oxide particle entering simultaneously, makes to stop on the skin surface, both strengthens the absorption of zinc oxide to the ultraviolet ray, can prevent again that zinc oxide from entering into and causing the damage in the human body. The skin secretion of infants is small and sensitive, and chemical molecules are blocked outside by adopting a squalane barrier membrane to prevent the skin from absorbing the skin, so that the skin care product can be applied to the infants.
3. The skin moisturizer is added with the raw materials, such as hesperidin, hyaluronic acid, nicotinamide and the like, so that the skin moisturizer can be deeply shrunk and moisturized, the skin barrier can be repaired, and the skin resistance can be improved; trehalose is added as a protective agent of active ingredients such as hyaluronic acid, hesperidin and the like to prevent the active ingredients from being decomposed, so that the storage time of the product is prolonged; the ferulic acid, the plant extract and the like are added, so that the compound has the effects of resisting bacteria and diminishing inflammation, can quickly diminish inflammation of wounds, further promotes the repair of squalane to damaged cells, and particularly has an excellent treatment effect on infantile eczema and dermatitis.
In conclusion, the skin care product has the advantages of sun screening, inflammation diminishing, wound cell growth promoting, health and safety, and can be suitable for infant skin care or treatment of infant eczema dermatitis.
The embodiments described above are some, but not all embodiments of the present application. The detailed description of the embodiments of the present application is not intended to limit the scope of the claimed application, but is merely representative of selected embodiments of the application. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
Claims (10)
1. A skin care product containing supramolecular zinc oxide, comprising the following raw materials: supramolecular zinc oxide, squalane, sweet almond oil, nicotinamide, trehalose, 1, 3-butanediol, disodium ethylenediaminetetraacetate, hyaluronic acid, xanthan gum, glycerol stearic acid, ferulic acid, hesperidin, plant extract and water.
2. The skin care product containing supramolecular zinc oxide as claimed in claim 1, comprising the following raw materials in parts by weight: 5-10 parts of supramolecular zinc oxide, 6-12 parts of squalane, 4-8 parts of sweet almond oil, 1-3 parts of nicotinamide, 1-3 parts of trehalose, 0.5-3 parts of 1, 3-butanediol, 0.5-2 parts of disodium ethylene diamine tetraacetate, 2-5 parts of hyaluronic acid, 1-3 parts of xanthan gum, 0.4-1.5 parts of glycerol stearic acid, 0.6-1.5 parts of ferulic acid, 0.1-1 part of hesperidin, 1-3 parts of plant extract and 60-70 parts of water.
3. The skin care product containing supramolecular zinc oxide as claimed in claim 2, characterized in that, in parts by weight, comprises the following raw materials: 8 parts of supramolecular zinc oxide, 8 parts of squalane, 6 parts of sweet almond oil, 2 parts of nicotinamide, 2 parts of trehalose, 1.5 parts of 1, 3-butanediol, 1 part of disodium ethylene diamine tetraacetate, 3 parts of hyaluronic acid, 2 parts of xanthan gum, 1 part of glycerol stearic acid, 1 part of ferulic acid, 0.5 part of hesperidin, 2 parts of plant extract and 62 parts of water.
4. The skin care product containing supramolecular zinc oxide as claimed in any one of claims 1 to 3, wherein said plant extract comprises at least three of extract of Artocarpus macrocarpa, extract of Glycyrrhiza glabra, extract of centella asiatica, extract of Viola yedoensis and extract of Mentha haplocalyx.
5. A skin care product comprising supramolecular zinc oxide as claimed in any one of claims 1 to 3, wherein said supramolecular zinc oxide is prepared by: mixing ethyl acetate, cyclohexane and water to prepare a reaction system, adjusting the pH value of the reaction system to 9.5-10 by adopting a buffer solution, heating, adding polyethylene glycol, adding a zinc acetate solution, and performing ultrasonic dispersion for 1-2 hours to obtain the supermolecule zinc oxide.
6. Skin care product containing supramolecular zinc oxide, according to claim 5, characterized in that said volume ratio of ethyl acetate, cyclohexane and water is 1: (2-3): (5-10), and the temperature after temperature rise is 35-45 ℃.
7. Skin care product containing supramolecular zinc oxide, according to claim 6, characterized in that said ethylene glycol is added in a volume of 1/50 of the volume of the reaction system, the ratio of acetic acid to reaction system in volume is 1: (10-20).
8. A process for the preparation of a skin care product containing supramolecular zinc oxide as claimed in any one of claims 1 to 7, comprising the steps of:
heating and mixing supramolecular zinc oxide, water, xanthan gum, 1,3 butanediol and plant extract to obtain a mixture water phase;
heating, homogenizing and dispersing squalane, sweet almond oil, nicotinamide, trehalose, disodium ethylene diamine tetraacetate, hyaluronic acid, glycerol stearic acid, ferulic acid and hesperidin to obtain an oil phase;
and adding the water phase into the oil phase, homogenizing, cooling to 40-50 ℃, homogenizing again, and cooling to room temperature to obtain the skin care product containing the supramolecular zinc oxide.
9. Process for the preparation of a skin care product containing supramolecular zinc oxide as claimed in claim 8, characterized in that said heating temperature is 70-80 ℃.
10. The method of claim 8, wherein the homogenization rate is 8000-10000r/min, and the time for each homogenization is 10-20min.
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