CN115778828A - Cosmetic composition containing fullerene - Google Patents
Cosmetic composition containing fullerene Download PDFInfo
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- CN115778828A CN115778828A CN202310098000.9A CN202310098000A CN115778828A CN 115778828 A CN115778828 A CN 115778828A CN 202310098000 A CN202310098000 A CN 202310098000A CN 115778828 A CN115778828 A CN 115778828A
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- Prior art keywords
- sodium hyaluronate
- vitamin
- cosmetic composition
- fullerene
- extract
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- 239000000203 mixture Substances 0.000 title claims abstract description 90
- XMWRBQBLMFGWIX-UHFFFAOYSA-N C60 fullerene Chemical compound C12=C3C(C4=C56)=C7C8=C5C5=C9C%10=C6C6=C4C1=C1C4=C6C6=C%10C%10=C9C9=C%11C5=C8C5=C8C7=C3C3=C7C2=C1C1=C2C4=C6C4=C%10C6=C9C9=C%11C5=C5C8=C3C3=C7C1=C1C2=C4C6=C2C9=C5C3=C12 XMWRBQBLMFGWIX-UHFFFAOYSA-N 0.000 title claims abstract description 56
- 229910003472 fullerene Inorganic materials 0.000 title claims abstract description 53
- 239000002537 cosmetic Substances 0.000 title claims abstract description 44
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 70
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 70
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 70
- QMVPMAAFGQKVCJ-UHFFFAOYSA-N citronellol Chemical compound OCCC(C)CCC=C(C)C QMVPMAAFGQKVCJ-UHFFFAOYSA-N 0.000 claims abstract description 42
- 239000000284 extract Substances 0.000 claims abstract description 35
- 229940088594 vitamin Drugs 0.000 claims abstract description 28
- 229930003231 vitamin Natural products 0.000 claims abstract description 28
- 235000013343 vitamin Nutrition 0.000 claims abstract description 28
- 239000011782 vitamin Substances 0.000 claims abstract description 28
- QMVPMAAFGQKVCJ-SNVBAGLBSA-N (R)-(+)-citronellol Natural products OCC[C@H](C)CCC=C(C)C QMVPMAAFGQKVCJ-SNVBAGLBSA-N 0.000 claims abstract description 21
- 241000272503 Sparassis radicata Species 0.000 claims abstract description 21
- JGQFVRIQXUFPAH-UHFFFAOYSA-N beta-citronellol Natural products OCCC(C)CCCC(C)=C JGQFVRIQXUFPAH-UHFFFAOYSA-N 0.000 claims abstract description 21
- 235000000484 citronellol Nutrition 0.000 claims abstract description 21
- 102000008186 Collagen Human genes 0.000 claims abstract description 19
- 108010035532 Collagen Proteins 0.000 claims abstract description 19
- 229920001436 collagen Polymers 0.000 claims abstract description 19
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 43
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 32
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 32
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 32
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 30
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims description 28
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 23
- 229920002674 hyaluronan Polymers 0.000 claims description 23
- 229960003160 hyaluronic acid Drugs 0.000 claims description 23
- 150000004676 glycans Chemical class 0.000 claims description 22
- 229920001282 polysaccharide Polymers 0.000 claims description 22
- 239000005017 polysaccharide Substances 0.000 claims description 22
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 17
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 16
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims description 16
- 229930003268 Vitamin C Natural products 0.000 claims description 16
- 229930003427 Vitamin E Natural products 0.000 claims description 16
- 229960000304 folic acid Drugs 0.000 claims description 16
- 235000019152 folic acid Nutrition 0.000 claims description 16
- 239000011724 folic acid Substances 0.000 claims description 16
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 16
- 229960003966 nicotinamide Drugs 0.000 claims description 16
- 235000005152 nicotinamide Nutrition 0.000 claims description 16
- 239000011570 nicotinamide Substances 0.000 claims description 16
- 235000019154 vitamin C Nutrition 0.000 claims description 16
- 239000011718 vitamin C Substances 0.000 claims description 16
- 235000019165 vitamin E Nutrition 0.000 claims description 16
- 229940046009 vitamin E Drugs 0.000 claims description 16
- 239000011709 vitamin E Substances 0.000 claims description 16
- 235000011187 glycerol Nutrition 0.000 claims description 15
- 229940059958 centella asiatica extract Drugs 0.000 claims description 13
- 240000005959 Abelmoschus manihot Species 0.000 claims description 12
- 235000001075 Abelmoschus manihot Nutrition 0.000 claims description 12
- 229940002386 calendula officinalis extract Drugs 0.000 claims description 12
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 claims description 2
- 229940035437 1,3-propanediol Drugs 0.000 claims description 2
- 229960005150 glycerol Drugs 0.000 claims description 2
- 229920000166 polytrimethylene carbonate Polymers 0.000 claims description 2
- 230000003647 oxidation Effects 0.000 abstract description 8
- 238000007254 oxidation reaction Methods 0.000 abstract description 8
- 230000000694 effects Effects 0.000 abstract description 6
- 238000005282 brightening Methods 0.000 abstract description 4
- 238000003756 stirring Methods 0.000 description 22
- 239000000341 volatile oil Substances 0.000 description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 15
- 238000010438 heat treatment Methods 0.000 description 14
- 238000002360 preparation method Methods 0.000 description 10
- 238000001816 cooling Methods 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 description 6
- 230000003020 moisturizing effect Effects 0.000 description 6
- 150000003254 radicals Chemical class 0.000 description 6
- 230000003078 antioxidant effect Effects 0.000 description 5
- 239000012467 final product Substances 0.000 description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- 244000166675 Cymbopogon nardus Species 0.000 description 4
- 235000018791 Cymbopogon nardus Nutrition 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 239000010632 citronella oil Substances 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- 235000011194 food seasoning agent Nutrition 0.000 description 3
- 239000010410 layer Substances 0.000 description 3
- 239000002502 liposome Substances 0.000 description 3
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 description 2
- 229920001661 Chitosan Polymers 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- 206010040829 Skin discolouration Diseases 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- NEHNMFOYXAPHSD-UHFFFAOYSA-N citronellal Chemical compound O=CCC(C)CCC=C(C)C NEHNMFOYXAPHSD-UHFFFAOYSA-N 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000000077 insect repellent Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 235000013372 meat Nutrition 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 229940083466 soybean lecithin Drugs 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 230000002087 whitening effect Effects 0.000 description 2
- NPNUFJAVOOONJE-ZIAGYGMSSA-N β-(E)-Caryophyllene Chemical compound C1CC(C)=CCCC(=C)[C@H]2CC(C)(C)[C@@H]21 NPNUFJAVOOONJE-ZIAGYGMSSA-N 0.000 description 2
- AJBZENLMTKDAEK-UHFFFAOYSA-N 3a,5a,5b,8,8,11a-hexamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-4,9-diol Chemical compound CC12CCC(O)C(C)(C)C1CCC(C1(C)CC3O)(C)C2CCC1C1C3(C)CCC1C(=C)C AJBZENLMTKDAEK-UHFFFAOYSA-N 0.000 description 1
- NVEQFIOZRFFVFW-UHFFFAOYSA-N 9-epi-beta-caryophyllene oxide Natural products C=C1CCC2OC2(C)CCC2C(C)(C)CC21 NVEQFIOZRFFVFW-UHFFFAOYSA-N 0.000 description 1
- 241001075517 Abelmoschus Species 0.000 description 1
- 235000009434 Actinidia chinensis Nutrition 0.000 description 1
- 244000298697 Actinidia deliciosa Species 0.000 description 1
- 235000009436 Actinidia deliciosa Nutrition 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 244000251953 Agaricus brunnescens Species 0.000 description 1
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- 235000003880 Calendula Nutrition 0.000 description 1
- 240000001432 Calendula officinalis Species 0.000 description 1
- 240000004784 Cymbopogon citratus Species 0.000 description 1
- 235000017897 Cymbopogon citratus Nutrition 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 239000005792 Geraniol Substances 0.000 description 1
- GLZPCOQZEFWAFX-YFHOEESVSA-N Geraniol Natural products CC(C)=CCC\C(C)=C/CO GLZPCOQZEFWAFX-YFHOEESVSA-N 0.000 description 1
- 244000170916 Paeonia officinalis Species 0.000 description 1
- 235000006484 Paeonia officinalis Nutrition 0.000 description 1
- 244000178231 Rosmarinus officinalis Species 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- FAMPSKZZVDUYOS-UHFFFAOYSA-N alpha-Caryophyllene Natural products CC1=CCC(C)(C)C=CCC(C)=CCC1 FAMPSKZZVDUYOS-UHFFFAOYSA-N 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- NPNUFJAVOOONJE-UHFFFAOYSA-N beta-cariophyllene Natural products C1CC(C)=CCCC(=C)C2CC(C)(C)C21 NPNUFJAVOOONJE-UHFFFAOYSA-N 0.000 description 1
- 229940117948 caryophyllene Drugs 0.000 description 1
- NPNUFJAVOOONJE-UONOGXRCSA-N caryophyllene Natural products C1CC(C)=CCCC(=C)[C@@H]2CC(C)(C)[C@@H]21 NPNUFJAVOOONJE-UONOGXRCSA-N 0.000 description 1
- 229930003633 citronellal Natural products 0.000 description 1
- 235000000983 citronellal Nutrition 0.000 description 1
- 229960005188 collagen Drugs 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- -1 elemenol Chemical compound 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 229940113087 geraniol Drugs 0.000 description 1
- 229910021389 graphene Inorganic materials 0.000 description 1
- 229910002804 graphite Inorganic materials 0.000 description 1
- 239000010439 graphite Substances 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 230000037067 skin hydration Effects 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention relates to the technical field of cosmetics, in particular to a cosmetic composition containing fullerene. The composition comprises the following components: the fullerene, the citronellol, the sparassis crispa extract, the sodium hyaluronate, the vitamins and the hydrolyzed collagen have the advantages of obvious effects of resisting oxidation, brightening skin and preserving moisture.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a cosmetic composition containing fullerene.
Background
Fullerene (Fullerene) is an allotrope of carbon, a hollow molecule composed entirely of carbon, and is in the shape of a sphere, ellipsoid, column or tube. Fullerenes are structurally similar to graphite, which is built up from graphene layers consisting of six-membered rings, whereas fullerenes contain not only six-membered rings but also five-membered rings and occasionally seven-membered rings.
Fullerene is known as diamond, and can be used for preparing sunscreen product by absorbing ultraviolet ray. Meanwhile, the fullerene has strong oxidation resistance and can delay skin aging. Fullerene molecules can catalytically scavenge free radicals, recombine free radicals, and thus, fullerene molecules can convert free radicals to inactive molecular products. Fullerene is proven to be a safe and non-toxic substance, and can be used as one of the ingredients of cosmetics.
Chinese patent application CN200480022252.9 discloses a cosmetic composition containing fullerene clusters. The composition comprises fullerene clusters and a carrier for preventing or delaying free radical oxidation processes in the skin. However, the technical content in this patent does not form a protective layer on the skin surface, and only the skin is appropriately repaired.
Chinese patent application CN201510074653.9 discloses a cosmetic composition containing fullerene derivatives. The composition comprises fullerene, polypeptide, hyaluronic acid, vitamin and collagen. The cosmetic composition of the present invention contains fullerene. The fullerene can strongly resist oxidation, can remove free radicals, and can resist aging and restore skin vitality after being used. The ingredients are matched for use, so that the water can be effectively supplemented, the skin can be moistened for a long time, and the whitening effect can be achieved. But the effects of the composition in terms of anti-oxidation, whitening and moisturizing are to be further improved.
Citronella is a very important flavoring spice, and in southeast Asia, meat foods such as roast chicken, roast fish, roast meat and the like are flavored by citronella grass, so that the taste is fresh, tender and delicious. Its stem and leaf can be directly used as flavoring or medicinal material, and plant volatile oil (i.e. enriched aroma component) can also be extracted. The volatile oil can be used in food, medicine, cosmetic, perfume, etc., and has antibacterial, mosquito repellent, and insect repellent effects.
For example, chinese patent application CN201811539397.6 discloses an essential oil composition for food seasoning and a preparation method thereof, which is refined from orange essential oil, neroli essential oil, champignon essential oil, rosemary essential oil, seasoning essential oil, kiwi seed essential oil, peony seed essential oil and lemongrass essential oil. The invention makes full use of different volatilization speeds of essential oil in different plant tissues, and ensures that the processed product has richer taste and flavor level. According to the invention, a simple and efficient extraction method is formulated according to the characteristics of each tissue of the plant in the preparation process of the essential oil, so that the extraction efficiency of the essential oil is higher, the activity of the essential oil product is higher, and the essential oil product can be used for seasoning, increasing the freshness and increasing the aroma of various foods.
Chinese patent application CN201510485092.1 discloses a high-stability citronella oil nano liposome antibacterial agent and a preparation method thereof. The invention relates to a citronella oil nano liposome prepared from citronella oil, soybean lecithin, cholesterol, a surfactant, chitosan and gelatin. The method comprises the steps of mixing citronella oil, soybean lecithin and cholesterol in an organic solvent, evaporating to dryness under reduced pressure to form a smooth film, adding an aqueous phase medium and a surfactant to dissolve the film-shaped material, performing ultrasonic emulsification, stirring uniformly with chitosan and gelatin solution, and filtering through a centrifugal filter membrane and a microporous filter membrane to obtain the liposome with the nano-scale particle size.
However, the effective components in citronella are numerous and include citronellol, citronellal, geraniol, elemenol, caryophyllene, and the like. How to effectively utilize the effective components in the citronella and apply the effective components to cosmetics to develop other purposes is a problem to be solved urgently in the field.
Therefore, it is very necessary to develop a cosmetic composition containing fullerene which can solve the above-mentioned technical problems.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide the cosmetic composition containing the fullerene with remarkable effects of resisting oxidation, brightening skin and moisturizing.
The invention is realized by the following technical scheme:
a cosmetic composition containing fullerene comprises the following components: fullerene, citronellol, sparassis crispa extract, sodium hyaluronate, vitamins and hydrolyzed collagen.
Preferably, the cosmetic composition comprises the following components in parts by weight: 0.5-3 parts of fullerene, 0.1-1 part of citronellol, 0.1-1 part of Sparassis crispa extract, 0.3-0.9 part of sodium hyaluronate, 0.4-1.5 parts of vitamin and 0.01-0.5 part of hydrolyzed collagen.
Preferably, the fullerene comprises C 60 、C 70 、C 76 And C 80 At least one of (1).
More preferably, the fullerene comprises C 60 And C 70 The mass ratio of the two is 1-3.
Preferably, the sodium hyaluronate is a mixture of macromolecular sodium hyaluronate, medium molecular sodium hyaluronate and small molecular sodium hyaluronate, and the weight ratio is 1; the molecular weight of the macromolecular sodium hyaluronate is 100-200 ten thousand Da, the molecular weight of the medium molecular sodium hyaluronate is 20-50 ten thousand Da, and the molecular weight of the small molecular sodium hyaluronate is 1-5 ten thousand Da.
The macromolecule sodium hyaluronate and the middle molecule sodium hyaluronate act on the surface of skin to form a moisturizing film, and the moisturizing film locks water and moisturizes; the micromolecular sodium hyaluronate acts on the horny layer and plays a role in locking water and keeping moisture in the horny layer.
Preferably, the vitamin is at least one of folic acid, vitamin C and vitamin E.
More preferably, the vitamin is a mixture of folic acid, vitamin C and vitamin E, and the mass ratio of the folic acid to the vitamin C to the vitamin E is 1-3.
The invention also relates to a preparation process of the cosmetic composition, which comprises the following steps:
(1) Adding fullerene, citronellol and Sparassis crispa extract into 1, 3-propylene glycol and water, heating and stirring until completely dissolved, and keeping the temperature for 20-40min to obtain component A;
(2) Adding sodium hyaluronate, vitamins and hydrolyzed collagen to obtain a mixture B;
(3) Adding oat polysaccharide, hyaluronic acid and nicotinamide into glycerol, and stirring until the oat polysaccharide, hyaluronic acid and nicotinamide are completely dissolved to obtain a mixture C;
(4) Adding the mixture C into the mixture B, stirring continuously, heating to 60-70 deg.C, keeping the temperature for 10-20min, and cooling.
Preferably, the cosmetic composition further comprises at least one of centella asiatica extract, calendula officinalis extract and abelmoschus manihot flower extract.
More preferably, the centella asiatica extract is added in an amount of 0.1-0.5 parts.
More preferably, the calendula extract is added in an amount of 0.2-0.8 parts.
More preferably, the addition amount of the sunset abelmoschus flower extract is 0.2-0.6 part.
More preferably, the cosmetic composition further comprises centella asiatica extract, calendula officinalis extract and abelmoschus manihot flower extract, wherein the mass ratio of the centella asiatica extract to the calendula officinalis extract to the abelmoschus manihot flower extract is 1-3.
Preferably, the cosmetic composition further comprises at least one of oat polysaccharide, hyaluronic acid, niacinamide, glycerin and 1, 3-propanediol.
More preferably, the cosmetic composition also comprises 0.1-0.15 part of oat polysaccharide, 0.05-0.15 part of hyaluronic acid, 0.05-0.1 part of nicotinamide, 2-6 parts of 1, 3-propylene glycol and 2-5 parts of glycerol.
The invention also relates to a preparation process of the cosmetic composition, which comprises the following steps:
(1) Adding fullerene, citronellol, and Sparassis crispa extract into 1, 3-propylene glycol and water, heating and stirring to dissolve completely, and keeping the temperature for 20-40min;
(2) Adding centella asiatica extract, calendula officinalis extract and abelmoschus manihot flower extract to obtain component A;
(3) Adding sodium hyaluronate, vitamins and hydrolyzed collagen to obtain a mixture B;
(4) Adding oat polysaccharide, hyaluronic acid and nicotinamide into glycerol, and stirring until the oat polysaccharide, hyaluronic acid and nicotinamide are completely dissolved to obtain a mixture C;
(5) Adding the mixture C into the mixture B, continuously stirring, heating to 60-70 deg.C, maintaining the temperature for 10-20min, and cooling to obtain the final product.
The invention has the beneficial effects that:
besides the fullerene, the citronellol and the sparassis crispa extract are added into the cosmetic composition, so that the synergistic effect of the citronellol and the sparassis crispa extract is remarkable, the antioxidant effect is obviously improved, and the skin lightening and moisturizing effects are good.
The cosmetic composition is also added with sodium hyaluronate, vitamins and hydrolyzed collagen, and the raw materials are matched for use, so that the antioxidant, skin lightening and moisturizing effects of the product can be further improved.
The inventor unexpectedly finds that the centella asiatica extract, the calendula officinalis extract and the abelmoschus manihot flower extract have remarkable synergistic effect in the aspects of oxidation resistance and skin color brightening, and when the composition is added into the composition, a large number of free radicals can be eliminated, the oxidation resistance duration is long, the generation of melanin is effectively reduced, and the skin color brightening effect is excellent.
Detailed Description
The invention will be further described with reference to specific embodiments, and the advantages and features of the invention will become apparent as the description proceeds. These examples are illustrative only and do not limit the scope of the present invention in any way. It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention, and that such changes and modifications may be made without departing from the spirit and scope of the invention.
The sparassis crispa extracts used in each example and comparative example were purchased from walteris biotechnology limited, lanzhou (10.
Example 1
A cosmetic composition containing fullerene comprises the following components in percentage by weight: 3% of fullerene, 0.1% of citronellol, 0.1% of sparassis crispa extract, 0.3% of sodium hyaluronate, 0.4% of vitamin, 0.01% of hydrolyzed collagen, 0.1% of oat polysaccharide, 0.05% of hyaluronic acid, 0.05% of nicotinamide, 2% of 1, 3-propylene glycol, 2% of glycerol and the balance of water;
the fullerene comprises C 60 And C 70 The mass ratio of the two is 1;
the sodium hyaluronate is a mixture of macromolecular sodium hyaluronate, medium molecular sodium hyaluronate and small molecular sodium hyaluronate, and the weight ratio is 1; the molecular weight of the macromolecular sodium hyaluronate is 100-200 ten thousand Da, the molecular weight of the medium molecular sodium hyaluronate is 20-50 ten thousand Da, and the molecular weight of the small molecular sodium hyaluronate is 1-5 ten thousand Da;
the vitamin is a mixture of folic acid, vitamin C and vitamin E, and the mass ratio of the folic acid to the vitamin C to the vitamin E is 1.
The preparation process of the cosmetic composition comprises the following steps:
(1) Adding fullerene, citronellol and Sparassis crispa extract into 1, 3-propylene glycol and water, heating and stirring until completely dissolved, and keeping the temperature for 20min to obtain component A;
(2) Adding sodium hyaluronate, vitamins and hydrolyzed collagen to obtain a mixture B;
(3) Adding oat polysaccharide, hyaluronic acid and nicotinamide into glycerol, and stirring until the oat polysaccharide, hyaluronic acid and nicotinamide are completely dissolved to obtain a mixture C;
(4) Adding the mixture C into the mixture B, continuously stirring, heating to 60 deg.C, keeping the temperature for 10min, and cooling.
Example 2
A cosmetic composition containing fullerene comprises the following components in percentage by weight: 0.5% of fullerene, 1% of citronellol, 1% of sparassis crispa extract, 0.9% of sodium hyaluronate, 1.5% of vitamin, 0.5% of hydrolyzed collagen, 0.15% of oat polysaccharide, 0.15% of hyaluronic acid, 0.1% of nicotinamide, 6% of 1, 3-propylene glycol, 5% of glycerol and the balance of water;
the fullerene comprises C 60 And C 70 In a mass ratio of3:1；
The sodium hyaluronate is a mixture of macromolecular sodium hyaluronate, medium molecular sodium hyaluronate and small molecular sodium hyaluronate, and the weight ratio is 1; the molecular weight of the macromolecular sodium hyaluronate is 100-200 ten thousand Da, the molecular weight of the middle molecular sodium hyaluronate is 20-50 ten thousand Da, and the molecular weight of the small molecular sodium hyaluronate is 1-5 ten thousand Da;
the vitamin is a mixture of folic acid, vitamin C and vitamin E, and the mass ratio of the folic acid to the vitamin C to the vitamin E is 1.
The preparation process of the cosmetic composition comprises the following steps:
(1) Adding fullerene, citronellol and Sparassis crispa extract into 1, 3-propylene glycol and water, heating and stirring until completely dissolved, and keeping the temperature for 40min to obtain component A;
(2) Adding sodium hyaluronate, vitamins and hydrolyzed collagen to obtain a mixture B;
(3) Adding oat polysaccharide, hyaluronic acid and nicotinamide into glycerol, and stirring until the oat polysaccharide, hyaluronic acid and nicotinamide are completely dissolved to obtain a mixture C;
(4) Adding the mixture C into the mixture B, continuously stirring, heating to 70 deg.C, keeping the temperature for 20min, and cooling to obtain the final product.
Example 3
A cosmetic composition containing fullerene comprises the following components in percentage by weight: 1.5% of fullerene, 0.5% of citronellol, 0.5% of sparassis crispa extract, 0.6% of sodium hyaluronate, 1% of vitamin, 0.25% of hydrolyzed collagen, 0.12% of oat polysaccharide, 0.1% of hyaluronic acid, 0.08% of nicotinamide, 4% of 1, 3-propylene glycol, 3% of glycerol and the balance of water;
the fullerene comprises C 60 And C 70 The mass ratio of the two is 2;
the sodium hyaluronate is a mixture of macromolecular sodium hyaluronate, medium molecular sodium hyaluronate and small molecular sodium hyaluronate, and the weight ratio is 1; the molecular weight of the macromolecular sodium hyaluronate is 100-200 ten thousand Da, the molecular weight of the medium molecular sodium hyaluronate is 20-50 ten thousand Da, and the molecular weight of the small molecular sodium hyaluronate is 1-5 ten thousand Da;
the vitamin is a mixture of folic acid, vitamin C and vitamin E, and the mass ratio of the folic acid to the vitamin C to the vitamin E is 1.
The preparation process of the cosmetic composition comprises the following steps:
(1) Adding fullerene, citronellol and Sparassis crispa extract into 1, 3-propylene glycol and water, heating and stirring to dissolve completely, and keeping the temperature for 30min to obtain component A;
(2) Adding sodium hyaluronate, vitamins and hydrolyzed collagen to obtain a mixture B;
(3) Adding oat polysaccharide, hyaluronic acid and nicotinamide into glycerol, and stirring until the oat polysaccharide, hyaluronic acid and nicotinamide are completely dissolved to obtain a mixture C;
(4) Adding the mixture C into the mixture B, continuously stirring, heating to 65 ℃, keeping the temperature for 15min, and cooling to obtain the final product.
Example 4
A cosmetic composition containing fullerene comprises the following components in percentage by weight: 1.5% of fullerene, 0.5% of citronellol, 0.5% of sparassis crispa extract, 0.6% of sodium hyaluronate, 1% of vitamin, 0.25% of hydrolyzed collagen, 0.2% of centella asiatica extract, 0.2% of calendula officinalis extract, 0.2% of flower of abelmoschus manihot extract, 0.12% of oat polysaccharide, 0.1% of hyaluronic acid, 0.08% of nicotinamide, 4% of 1, 3-propylene glycol, 3% of glycerol and the balance of water;
the fullerene comprises C 60 And C 70 The mass ratio of the two is 2;
the sodium hyaluronate is a mixture of macromolecular sodium hyaluronate, medium molecular sodium hyaluronate and small molecular sodium hyaluronate, and the weight ratio is 1; the molecular weight of the macromolecular sodium hyaluronate is 100-200 ten thousand Da, the molecular weight of the medium molecular sodium hyaluronate is 20-50 ten thousand Da, and the molecular weight of the small molecular sodium hyaluronate is 1-5 ten thousand Da;
the vitamin is a mixture of folic acid, vitamin C and vitamin E, and the mass ratio of the folic acid to the vitamin C to the vitamin E is 1.
The preparation process of the cosmetic composition comprises the following steps:
(1) Adding fullerene, citronellol and Sparassis crispa extract into 1, 3-propylene glycol and water, heating and stirring to dissolve completely, and keeping the temperature for 30min;
(2) Adding centella asiatica extract, calendula officinalis extract and abelmoschus manihot flower extract to obtain component A;
(3) Adding sodium hyaluronate, vitamins and hydrolyzed collagen to obtain a mixture B;
(4) Adding oat polysaccharide, hyaluronic acid and nicotinamide into glycerol, and stirring until the oat polysaccharide, hyaluronic acid and nicotinamide are completely dissolved to obtain a mixture C;
(5) Adding the mixture C into the mixture B, continuously stirring, heating to 65 ℃, keeping the temperature for 15min, and cooling to obtain the final product.
Example 5
A cosmetic composition containing fullerene comprises the following components in percentage by weight: 1.5% of fullerene, 0.5% of citronellol, 0.5% of sparassis crispa extract, 0.6% of sodium hyaluronate, 1% of vitamin, 0.25% of hydrolyzed collagen, 0.2% of centella asiatica extract, 0.6% of calendula officinalis extract, 0.4% of flower of abelmoschus manihot extract, 0.12% of oat polysaccharide, 0.1% of hyaluronic acid, 0.08% of nicotinamide, 4% of 1, 3-propylene glycol, 3% of glycerol and the balance of water;
the fullerene comprises C 60 And C 70 The mass ratio of the two is 2;
the sodium hyaluronate is a mixture of macromolecular sodium hyaluronate, medium molecular sodium hyaluronate and small molecular sodium hyaluronate, and the weight ratio is 1; the molecular weight of the macromolecular sodium hyaluronate is 100-200 ten thousand Da, the molecular weight of the medium molecular sodium hyaluronate is 20-50 ten thousand Da, and the molecular weight of the small molecular sodium hyaluronate is 1-5 ten thousand Da;
the vitamin is a mixture of folic acid, vitamin C and vitamin E, and the mass ratio of the folic acid to the vitamin C to the vitamin E is 1.
The preparation process of the cosmetic composition comprises the following steps:
(1) Adding fullerene, citronellol and Sparassis crispa extract into 1, 3-propylene glycol and water, heating and stirring to dissolve completely, and keeping the temperature for 30min;
(2) Adding centella asiatica extract, calendula officinalis extract and abelmoschus manihot flower extract to obtain component A;
(3) Adding sodium hyaluronate, vitamins and hydrolyzed collagen to obtain a mixture B;
(4) Adding oat polysaccharide, hyaluronic acid and nicotinamide into glycerol, and stirring until the oat polysaccharide, hyaluronic acid and nicotinamide are completely dissolved to obtain a mixture C;
(5) Adding the mixture C into the mixture B, continuously stirring, heating to 65 ℃, keeping the temperature for 15min, and cooling to obtain the final product.
Comparative examples 1 to 3
The differences from example 3 are only in the amounts of fullerene, citronellol and Sparassis crispa extract in the composition, and the other conditions are the same, as shown in Table 1.
TABLE 1
Comparative examples 4 to 7
The difference from example 4 is only the amount of centella asiatica extract, calendula officinalis extract and abelmoschus manihot flower extract in the composition, and the rest conditions are the same, as shown in table 2.
TABLE 2
Test example 1
Oxidation resistance test
The antioxidant activity (AOA) of each example and comparative example was measured, and the AOA represents the coulomb consumption for titrating 100g of the analyzed substance, as shown in table 3.
TABLE 3
Test example 2
Skin complexion L value was measured by using a Colorimeter CL400, a skin color tester manufactured by Courage Khazaka (CK) of germany, and the influence thereof on skin penetration brightness was evaluated by measuring the change in the L value of the skin before and after the product was used, and subjects having the same mean value of the initial L value were examined for 6 persons per group for a period of 4 weeks, and the results were averaged as shown in table 4.
TABLE 4
Test example 3
Skin hydration was measured to give the same initial mean value for each group of subjects, 6 people per group, for four weeks, and the results averaged, as shown in table 5.
TABLE 5
The above detailed description is specific to one possible embodiment of the present invention, and the embodiment is not intended to limit the scope of the present invention, and all equivalent implementations or modifications without departing from the scope of the present invention should be included in the technical scope of the present invention.
Claims (10)
1. A cosmetic composition comprising fullerene, comprising the following components: fullerene, citronellol, sparassis crispa extract, sodium hyaluronate, vitamins and hydrolyzed collagen.
2. The cosmetic composition according to claim 1, comprising the following components in parts by weight: 0.5-3 parts of fullerene, 0.1-1 part of citronellol, 0.1-1 part of sparassis crispa extract, 0.3-0.9 part of sodium hyaluronate, 0.4-1.5 parts of vitamin and 0.01-0.5 part of hydrolyzed collagen.
3. Cosmetic composition according to claim 1 or 2, characterized in that said fullerene comprises C 60 、C 70 、C 76 And C 80 At least one of (1).
4. The cosmetic composition of claim 3, wherein said fullerene comprises C 60 And C 70 1-3, wherein the mass ratio of the two is 1-1.
5. The cosmetic composition according to claim 1 or 2, wherein the sodium hyaluronate is a mixture of macromolecular sodium hyaluronate, medium molecular sodium hyaluronate and small molecular sodium hyaluronate, in a weight ratio of 1; the molecular weight of the macromolecular sodium hyaluronate is 100-200 ten thousand Da, the molecular weight of the medium molecular sodium hyaluronate is 20-50 ten thousand Da, and the molecular weight of the small molecular sodium hyaluronate is 1-5 ten thousand Da.
6. The cosmetic composition of claim 1 or 2, wherein the vitamin is at least one of folic acid, vitamin C and vitamin E.
7. The cosmetic composition according to claim 6, wherein the vitamin is a mixture of folic acid, vitamin C and vitamin E, and the mass ratio of the folic acid, the vitamin C and the vitamin E is 1-3.
8. The cosmetic composition of claim 1 or 2, further comprising at least one of centella asiatica extract, calendula officinalis extract and abelmoschus manihot extract.
9. The cosmetic composition of claim 8, further comprising centella asiatica extract, calendula officinalis extract and abelmoschus manihot flower extract in a mass ratio of 1 to 3.
10. The cosmetic composition of claim 1 or 2, further comprising at least one of oat polysaccharide, hyaluronic acid, niacinamide, glycerin, and 1, 3-propanediol.
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