CN115768445A - 靶向IL13Rα2的通用型CAR-T细胞及其制备方法和应用 - Google Patents

靶向IL13Rα2的通用型CAR-T细胞及其制备方法和应用 Download PDF

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Publication number
CN115768445A
CN115768445A CN202280004526.XA CN202280004526A CN115768445A CN 115768445 A CN115768445 A CN 115768445A CN 202280004526 A CN202280004526 A CN 202280004526A CN 115768445 A CN115768445 A CN 115768445A
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immune effector
seq
effector cell
amino acid
acid sequence
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尚小云
李甲璐
蒋海娟
王丹
马少文
沈慧
徐凡丽
王世臣
陈伟杰
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Ningbo Maoxing Biomedical Technology Co ltd
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Ningbo Maoxing Biomedical Technology Co ltd
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
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    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K2239/11—Antigen recognition domain
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    • C07K2319/00—Fusion polypeptide
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CN202280004526.XA 2021-07-01 2022-06-30 靶向IL13Rα2的通用型CAR-T细胞及其制备方法和应用 Pending CN115768445A (zh)

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CN202110749536 2021-07-01
CN2021107495363 2021-07-01
PCT/CN2022/103037 WO2023274380A1 (zh) 2021-07-01 2022-06-30 靶向IL13Rα2的通用型CAR-T细胞及其制备方法和应用

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US (1) US20240376216A1 (https=)
EP (1) EP4364746A4 (https=)
JP (1) JP2024527539A (https=)
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WO (1) WO2023274380A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025025597A1 (zh) * 2023-08-03 2025-02-06 森妙生物科技(西安)有限公司 一种抗体或其抗原结合片段及其应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104936621A (zh) * 2012-11-07 2015-09-23 辉瑞公司 抗IL-13受体α2抗体和抗体-药物缀合物
CN107723275A (zh) * 2017-10-20 2018-02-23 重庆精准生物技术有限公司 通用型car‑t细胞及其制备方法和应用
CN111051502A (zh) * 2017-09-06 2020-04-21 亘喜生物科技（上海）有限公司 通用型嵌合抗原受体t细胞制备技术
CN112236151A (zh) * 2018-03-14 2021-01-15 西雅图儿童医院（Dba西雅图儿童研究所） 用于肿瘤特异性T细胞免疫疗法的IL-13受体α2(IL13RA2)嵌合抗原受体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10391126B2 (en) * 2011-11-18 2019-08-27 Board Of Regents, The University Of Texas System CAR+ T cells genetically modified to eliminate expression of T-cell receptor and/or HLA
US12083148B2 (en) * 2017-02-22 2024-09-10 H. Lee Moffitt Cancer Center And Research Institute, Inc. IL13Ra2-binding chimeric antigen receptors
ES2928296T3 (es) * 2017-06-30 2022-11-16 Us Health Receptores de antígenos quiméricos anti-antígenos de maduración de linfocitos B con dominios humanos
JP7748935B2 (ja) 2019-08-27 2025-10-03 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア ＩＬ１３Ｒα２陽性ヒト腫瘍およびイヌ腫瘍を処置するための合成ＣＡＲ

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104936621A (zh) * 2012-11-07 2015-09-23 辉瑞公司 抗IL-13受体α2抗体和抗体-药物缀合物
CN111051502A (zh) * 2017-09-06 2020-04-21 亘喜生物科技（上海）有限公司 通用型嵌合抗原受体t细胞制备技术
CN107723275A (zh) * 2017-10-20 2018-02-23 重庆精准生物技术有限公司 通用型car‑t细胞及其制备方法和应用
CN112236151A (zh) * 2018-03-14 2021-01-15 西雅图儿童医院（Dba西雅图儿童研究所） 用于肿瘤特异性T细胞免疫疗法的IL-13受体α2(IL13RA2)嵌合抗原受体

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US20240376216A1 (en) 2024-11-14
EP4364746A1 (en) 2024-05-08
WO2023274380A1 (zh) 2023-01-05
JP2024527539A (ja) 2024-07-25
EP4364746A4 (en) 2025-07-23

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