JP2024527539A - ＩＬ１３Ｒα２を標的としたユニバーサルＣＡＲ－Ｔ細胞及びその製造方法と使用 - Google Patents

ＩＬ１３Ｒα２を標的としたユニバーサルＣＡＲ－Ｔ細胞及びその製造方法と使用 Download PDF

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JP2024527539A
JP2024527539A JP2023580404A JP2023580404A JP2024527539A JP 2024527539 A JP2024527539 A JP 2024527539A JP 2023580404 A JP2023580404 A JP 2023580404A JP 2023580404 A JP2023580404 A JP 2023580404A JP 2024527539 A JP2024527539 A JP 2024527539A
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seq
immune effector
amino acid
acid sequence
cells
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小云 尚
甲▲ルゥ▼ 李
海娟 蒋
丹 王
少文 馬
慧 沈
凡麗 徐
世臣 王
偉杰 陳
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寧波茂行生物医薬科技有限公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
    • A61K40/4211—CD19 or B4
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4214—Receptors for cytokines
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    • C07K14/70503—Immunoglobulin superfamily
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • A61K2239/11—Antigen recognition domain
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C12N2310/00—Structure or type of the nucleic acid
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JP2023580404A 2021-07-01 2022-06-30 ＩＬ１３Ｒα２を標的としたユニバーサルＣＡＲ－Ｔ細胞及びその製造方法と使用 Pending JP2024527539A (ja)

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CN202110749536 2021-07-01
CN202110749536.3 2021-07-01
PCT/CN2022/103037 WO2023274380A1 (zh) 2021-07-01 2022-06-30 靶向IL13Rα2的通用型CAR-T细胞及其制备方法和应用

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JP2024527539A true JP2024527539A (ja) 2024-07-25
JP2024527539A5 JP2024527539A5 (https=) 2025-07-07

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US (1) US20240376216A1 (https=)
EP (1) EP4364746A4 (https=)
JP (1) JP2024527539A (https=)
CN (1) CN115768445A (https=)
WO (1) WO2023274380A1 (https=)

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WO2025025597A1 (zh) * 2023-08-03 2025-02-06 森妙生物科技(西安)有限公司 一种抗体或其抗原结合片段及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20200061114A1 (en) * 2017-02-22 2020-02-27 H. Lee Moffitt Cancer Center And Research Institute, Inc. Il13ra2-binding chimeric antigen receptors
EP3680328A1 (en) * 2017-09-06 2020-07-15 Gracell Biotechnologies (Shanghai) Co., Ltd. Universal chimeric antigen receptor t-cell preparation technique

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10391126B2 (en) * 2011-11-18 2019-08-27 Board Of Regents, The University Of Texas System CAR+ T cells genetically modified to eliminate expression of T-cell receptor and/or HLA
KR101763499B1 (ko) 2012-11-07 2017-07-31 화이자 인코포레이티드 항-il-13 수용체 알파 2 항체 및 항체-약물 접합체
ES2928296T3 (es) * 2017-06-30 2022-11-16 Us Health Receptores de antígenos quiméricos anti-antígenos de maduración de linfocitos B con dominios humanos
CN107723275B (zh) * 2017-10-20 2020-09-04 重庆精准生物技术有限公司 通用型car-t细胞及其制备方法和应用
EP3765041A4 (en) * 2018-03-14 2021-12-22 Seattle Children's Hospital (DBA Seattle Children's Research Institute) IL-13 CHIMERIC RECEPTOR ALPHA 2 (IL13RA2) ANTIGEN RECEPTOR FOR T-CELL T-CELL IMMUNOTHERAPY
JP7748935B2 (ja) 2019-08-27 2025-10-03 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア ＩＬ１３Ｒα２陽性ヒト腫瘍およびイヌ腫瘍を処置するための合成ＣＡＲ

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20200061114A1 (en) * 2017-02-22 2020-02-27 H. Lee Moffitt Cancer Center And Research Institute, Inc. Il13ra2-binding chimeric antigen receptors
EP3680328A1 (en) * 2017-09-06 2020-07-15 Gracell Biotechnologies (Shanghai) Co., Ltd. Universal chimeric antigen receptor t-cell preparation technique

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US20240376216A1 (en) 2024-11-14
EP4364746A1 (en) 2024-05-08
WO2023274380A1 (zh) 2023-01-05
CN115768445A (zh) 2023-03-07
EP4364746A4 (en) 2025-07-23

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