CN115721588A - A Chinese medicinal composition containing Ligustrum quihoui, pitaya stem extract and fructus Luffae tissue fluid, and its application in skin care product - Google Patents
A Chinese medicinal composition containing Ligustrum quihoui, pitaya stem extract and fructus Luffae tissue fluid, and its application in skin care product Download PDFInfo
- Publication number
- CN115721588A CN115721588A CN202211416230.7A CN202211416230A CN115721588A CN 115721588 A CN115721588 A CN 115721588A CN 202211416230 A CN202211416230 A CN 202211416230A CN 115721588 A CN115721588 A CN 115721588A
- Authority
- CN
- China
- Prior art keywords
- extract
- chinese medicine
- traditional chinese
- dragon fruit
- ligustrum quihoui
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000284 extract Substances 0.000 title claims abstract description 68
- 241001108829 Ligustrum quihoui Species 0.000 title claims abstract description 40
- 239000000203 mixture Substances 0.000 title claims abstract description 35
- 239000012530 fluid Substances 0.000 title claims abstract description 18
- 235000010837 Echinocereus enneacanthus subsp brevispinus Nutrition 0.000 title description 8
- 235000006850 Echinocereus enneacanthus var dubius Nutrition 0.000 title description 8
- 240000008086 Echinocereus enneacanthus Species 0.000 title 1
- 244000157072 Hylocereus undatus Species 0.000 claims abstract description 43
- 235000018481 Hylocereus undatus Nutrition 0.000 claims abstract description 36
- 239000003814 drug Substances 0.000 claims abstract description 36
- 235000009852 Cucurbita pepo Nutrition 0.000 claims abstract description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
- 230000001815 facial effect Effects 0.000 claims abstract description 8
- 239000002884 skin cream Substances 0.000 claims abstract description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 56
- 241000219122 Cucurbita Species 0.000 claims description 25
- 239000000243 solution Substances 0.000 claims description 14
- 239000000047 product Substances 0.000 claims description 13
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 12
- 238000001914 filtration Methods 0.000 claims description 12
- 150000004676 glycans Chemical class 0.000 claims description 12
- 229920001282 polysaccharide Polymers 0.000 claims description 12
- 239000005017 polysaccharide Substances 0.000 claims description 12
- 230000002087 whitening effect Effects 0.000 claims description 10
- 239000000706 filtrate Substances 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 9
- 238000001035 drying Methods 0.000 claims description 8
- 238000002360 preparation method Methods 0.000 claims description 8
- 239000011347 resin Substances 0.000 claims description 8
- 229920005989 resin Polymers 0.000 claims description 8
- 230000032683 aging Effects 0.000 claims description 7
- -1 facial masks Substances 0.000 claims description 7
- 238000011068 loading method Methods 0.000 claims description 7
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 claims description 6
- 239000003463 adsorbent Substances 0.000 claims description 6
- 229930003944 flavone Natural products 0.000 claims description 6
- 150000002212 flavone derivatives Chemical class 0.000 claims description 6
- 235000011949 flavones Nutrition 0.000 claims description 6
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 claims description 6
- 230000003078 antioxidant effect Effects 0.000 claims description 5
- 229930003935 flavonoid Natural products 0.000 claims description 5
- 150000002215 flavonoids Chemical class 0.000 claims description 5
- 235000017173 flavonoids Nutrition 0.000 claims description 5
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 5
- 229930182470 glycoside Natural products 0.000 claims description 5
- 150000002338 glycosides Chemical class 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 150000003648 triterpenes Chemical class 0.000 claims description 5
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 4
- 241000735234 Ligustrum Species 0.000 claims description 4
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 4
- 229960003237 betaine Drugs 0.000 claims description 4
- 238000007865 diluting Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 238000010992 reflux Methods 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 239000003963 antioxidant agent Substances 0.000 claims description 3
- 235000006708 antioxidants Nutrition 0.000 claims description 2
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 2
- 241000345998 Calamus manan Species 0.000 claims 2
- 235000012950 rattan cane Nutrition 0.000 claims 2
- 238000004108 freeze drying Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 19
- 102000003425 Tyrosinase Human genes 0.000 abstract description 15
- 108060008724 Tyrosinase Proteins 0.000 abstract description 15
- 230000002401 inhibitory effect Effects 0.000 abstract description 9
- 230000003647 oxidation Effects 0.000 abstract description 3
- 238000007254 oxidation reaction Methods 0.000 abstract description 3
- 240000001980 Cucurbita pepo Species 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 description 21
- 210000003491 skin Anatomy 0.000 description 15
- 238000000034 method Methods 0.000 description 13
- 241000219138 Luffa Species 0.000 description 12
- 235000003956 Luffa Nutrition 0.000 description 12
- 150000003254 radicals Chemical class 0.000 description 9
- 210000004027 cell Anatomy 0.000 description 8
- 239000006071 cream Substances 0.000 description 7
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 244000302544 Luffa aegyptiaca Species 0.000 description 6
- 235000009814 Luffa aegyptiaca Nutrition 0.000 description 6
- 230000003064 anti-oxidating effect Effects 0.000 description 5
- 230000006872 improvement Effects 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 4
- 238000002835 absorbance Methods 0.000 description 4
- 230000006378 damage Effects 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 230000005764 inhibitory process Effects 0.000 description 4
- YPFDHNVEDLHUCE-UHFFFAOYSA-N propane-1,3-diol Chemical compound OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 description 4
- 206010067484 Adverse reaction Diseases 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 230000006838 adverse reaction Effects 0.000 description 3
- 230000003712 anti-aging effect Effects 0.000 description 3
- 235000019437 butane-1,3-diol Nutrition 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 238000006479 redox reaction Methods 0.000 description 3
- 238000007789 sealing Methods 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 description 2
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 description 2
- 208000012641 Pigmentation disease Diseases 0.000 description 2
- 206010042496 Sunburn Diseases 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 2
- 230000030833 cell death Effects 0.000 description 2
- 230000003833 cell viability Effects 0.000 description 2
- 230000009194 climbing Effects 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 239000004205 dimethyl polysiloxane Substances 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000003061 melanogenesis Effects 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 150000002978 peroxides Chemical class 0.000 description 2
- 230000019612 pigmentation Effects 0.000 description 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 2
- 239000007845 reactive nitrogen species Substances 0.000 description 2
- 239000003642 reactive oxygen metabolite Substances 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- RJZNPROJTJSYLC-LLINQDLYSA-N (4s)-4-acetamido-5-[[(2s)-1-[[(2s)-1-[[(2s)-5-amino-1-[[(2s)-1-[[(2s)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-car Chemical compound OC(=O)CC[C@H](NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O RJZNPROJTJSYLC-LLINQDLYSA-N 0.000 description 1
- 229940015975 1,2-hexanediol Drugs 0.000 description 1
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 description 1
- 241000219357 Cactaceae Species 0.000 description 1
- 206010008570 Chloasma Diseases 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 description 1
- 241000219104 Cucurbitaceae Species 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- 230000005778 DNA damage Effects 0.000 description 1
- 231100000277 DNA damage Toxicity 0.000 description 1
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 1
- 235000010254 Jasminum officinale Nutrition 0.000 description 1
- 240000005385 Jasminum sambac Species 0.000 description 1
- 208000003351 Melanosis Diseases 0.000 description 1
- 229920000715 Mucilage Polymers 0.000 description 1
- 241000207834 Oleaceae Species 0.000 description 1
- 240000006915 Petasites Species 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 229960001948 caffeine Drugs 0.000 description 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 229910001431 copper ion Inorganic materials 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000003779 hair growth Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- BEJNERDRQOWKJM-UHFFFAOYSA-N kojic acid Chemical compound OCC1=CC(=O)C(O)=CO1 BEJNERDRQOWKJM-UHFFFAOYSA-N 0.000 description 1
- 229960004705 kojic acid Drugs 0.000 description 1
- WZNJWVWKTVETCG-UHFFFAOYSA-N kojic acid Natural products OC(=O)C(N)CN1C=CC(=O)C(O)=C1 WZNJWVWKTVETCG-UHFFFAOYSA-N 0.000 description 1
- 210000002752 melanocyte Anatomy 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000009790 rate-determining step (RDS) Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 230000005808 skin problem Effects 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- 229940104256 sodium taurate Drugs 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine composition which is composed of a ligustrum quihoui extract, a dragon fruit stem extract and a towel gourd tissue fluid. The Chinese medicinal composition has definite activities of resisting oxidation and inhibiting tyrosinase, and can be applied to various skin care products such as facial masks, essence, floral water, skin cream, and the like.
Description
Technical Field
The invention relates to the technical field of medicines, and particularly relates to a traditional Chinese medicine composition containing ligustrum quihoui, dragon fruit stem extract and towel gourd tissue fluid and application of the traditional Chinese medicine composition in skin care products.
Background
With the continuous improvement of living standard of people, people pay more and more attention to the personal appearance. Therefore, skin care products have become a necessity for life of people. The main problems of face concerned by people are skin aging, dull complexion, melanin deposition and the like. Every time metabolism in a human body occurs, oxidation-reduction reaction occurs, and then free radicals are generated. A free radical is an atom, molecule or group containing an unpaired electron,generally, the redox reaction is characterized by a strong activity, a short lifetime, and a low concentration, and includes free radicals centered on oxygen, free radicals centered on nitrogen, and the like. Some molecules, although not free radicals, e.g. H 2 O 2 But is closely related to the generation and metabolism of free radicals, has strong redox reactivity, and is collectively called Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS) together with the free radicals. Due to the strong redox reaction activity of active oxygen/active nitrogen, electrons can be snatched from other molecules, so that cell membrane damage, protein damage, DNA damage and even whole cell function damage are caused. The aging free radical theory considers that the cell free radical is generated too much, when the antioxidant enzyme is insufficient, the free radical can not be cleared in time to cause apoptosis and tissue damage, which are the root causes of body aging. Therefore, the supply of antioxidant substances capable of scavenging free radicals from the outside is an effective method for protecting cells from aging damage.
Facial pigmentation including chloasma, post-inflammatory pigmentation (sunburn) and sunburn, etc., is another skin problem that afflicts consumers. Melanin is a major pigment produced by melanocytes in the skin, and tyrosinase, an enzyme that plays a fundamental role in melanogenesis, is a copper-containing metalloenzyme, has binuclear copper ions, and is the rate-limiting step in melanogenesis. Therefore, the whitening effect can be achieved by inhibiting key enzyme of tyrosinase-melanin generation.
The application of traditional Chinese medicine in skin care has a long history, and a large number of skin care and whitening empirical formulas are reserved in palace for the past. Therefore, the search for natural extracts with skin care effects in traditional Chinese medicines has important economic and social values.
Ligustrum quihouuicarr is shrub of Ligustrum genus of Oleaceae family, and its tender leaf is often drunk as folium Ilicis in southwest region, and has effects of clearing heat and detoxicating, and can be used for treating scald and trauma. But rarely ligustrum quihoui has application in skin care products.
Pitaya (scientific name: hylocereusundulanusBritt.) is a perennial climbing fleshy shrub plant of the family Cactaceae, genus Petasites, the fruit of which is a common, delicious fruit. The dragon fruit stems are rich in mucilage, polysaccharide and flavonoid components, but the medicinal use of the dragon fruit stems is not wide.
Luffa cylindrica (a scientific name: luffaaegyptiaca Miller) is an annual climbing vine plant of Cucurbitaceae, and the tissue exudate after cutting Luffa cylindrica contains rich components such as polysaccharide, plant mucus, vitamins, minerals and the like, is a natural moisturizing factor, and can relieve dry skin. Contains natural medicinal components, has the functions of clearing heat and diminishing inflammation, and is a good raw material of skin care products.
Based on the reasons, the invention provides a traditional Chinese medicine composition containing Ligustrum quihoui, dragon fruit stem extract and towel gourd tissue liquid, wherein the extract has good activities of resisting oxidation and inhibiting tyrosinase, and can be used in various skin care products such as facial masks, essence solutions, toilet water, skin cream and the like.
Disclosure of Invention
The invention mainly aims to provide a natural and safe traditional Chinese medicine composition for resisting oxidation and inhibiting tyrosinase, which has definite curative effect and few side effects, so as to solve the problems of poor anti-aging and whitening effects and the like of common skin care products in the prior art.
In order to achieve the above object, according to one aspect of the present invention, there is provided a Chinese medicinal composition comprising 1 to 10 parts of ligustrum quihoui extract, 1 to 10 parts of dragon fruit stem extract and 1 to 10 parts of towel gourd tissue fluid.
Further, the traditional Chinese medicine composition preferably comprises 4 parts of ligustrum quihoui extract, 5 parts of dragon fruit stem extract and 1 part of towel gourd tissue fluid.
Further, in the traditional Chinese medicine composition, the content of total flavonoids in the Ligustrum quihoui extract is more than or equal to 30%, the content of total triterpenoids is more than or equal to 20%, and the content of total phenylethanoid glycosides is more than or equal to 10%; the content of total polysaccharides in the dragon fruit stem extract is more than or equal to 30 percent, and the content of total flavonoids is more than or equal to 20 percent; the content of total polysaccharide in the towel gourd tissue fluid is more than or equal to 55 percent.
According to another aspect of the present invention, there is provided a method for preparing a ligustrum quihoui extract, comprising the steps of:
taking Ligustrum quihoui leaves, crushing into coarse powder, adding 20 times volume of extraction solvent (containing 0.3% betaine, 0.25% citric acid, 0.3% 1, 3% butanediol aqueous solution), reflux extracting for 2 hours, filtering, loading filtrate on D101 macroporous adsorbent resin, eluting with 5 times column volume of water, 10% ethanol and 70% ethanol, collecting 70% ethanol eluate, recovering ethanol, concentrating, and drying to obtain Ligustrum quihoui extract.
According to another aspect of the present invention, there is provided a method for preparing a dragon fruit stem extract, the method comprising the steps of:
squeezing fresh stems of pitaya to obtain juice, filtering, diluting filtrate with 8 times of water, applying the filtrate to D101 macroporous adsorption resin, sequentially eluting with 5 times of column volume of water and 50% ethanol, collecting water and 50% ethanol eluent, mixing, recovering ethanol, concentrating and drying to obtain the pitaya stem extract.
According to another aspect of the present invention, there is provided a method for preparing a luffa tissue fluid, comprising the steps of:
cutting off the part 30 cm above the root of luffa stem, inserting the upper end of stem into a clean bottle, sealing the bottle, allowing luffa solution to flow into the bottle, collecting, aging, concentrating, filtering, and lyophilizing.
According to another aspect of the invention, the application of the traditional Chinese medicine composition in the aspects of antioxidation and whitening efficacy and the application of the traditional Chinese medicine composition in various skin care products such as facial masks, essence solutions, toilet water, skin cream and the like are provided.
The invention has the beneficial effects that:
by applying the technical scheme, the traditional Chinese medicine composition is composed of a ligustrum quihoui extract, a dragon fruit stem extract and towel gourd tissue liquid, wherein the content of total flavone in the ligustrum quihoui extract is more than or equal to 30%, the content of total triterpene is more than or equal to 20%, and the content of total phenylethanoid glycoside is more than or equal to 10%; the content of total polysaccharide in the dragon fruit stem extract is more than or equal to 30 percent, and the content of total flavone is more than or equal to 20 percent; the content of total polysaccharide in the towel gourd tissue liquid is more than or equal to 55 percent. The traditional Chinese medicine composition has good antioxidation and tyrosinase inhibition activities, and well solves the problems of poor anti-aging and whitening effects and the like of common skin care products.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the embodiments of the present invention, and it should be apparent that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The present invention is intended to cover all alternatives, modifications and equivalents, which may be included in the field of the present invention as defined by the appended claims. Those skilled in the art will recognize many methods and materials similar or equivalent to those described herein which can be used in the practice of the present invention. The present invention is in no way limited to the description of methods and materials.
The articles "a", "an" and "the" as used herein are intended to include "at least one" or "one or more" unless otherwise indicated herein or clearly contradicted by context. Thus, as used herein, the articles refer to one or to more than one (i.e., to at least one) of the objects.
As described in the background section, the existing common skin care products have the problems of poor anti-aging and whitening effects, and the like. In order to solve the problems, the invention provides a traditional Chinese medicine composition which comprises a ligustrum quihoui extract, a dragon fruit stem extract and towel gourd tissue fluid, wherein the content of total flavonoids in the ligustrum quihoui extract is more than or equal to 30%, the content of total triterpenes is more than or equal to 20%, and the content of total phenylethanoid glycosides is more than or equal to 10%; the content of total polysaccharide in the dragon fruit stem extract is more than or equal to 30 percent, and the content of total flavone is more than or equal to 20 percent; the content of total polysaccharide in the towel gourd tissue liquid is more than or equal to 55 percent.
According to another aspect of the present invention, there is provided a method for preparing a ligustrum quihoui extract, comprising the steps of:
taking Ligustrum quihoui leaves, crushing into coarse powder, adding 20 times volume of extraction solvent (containing 0.3% betaine, 0.25% citric acid, 0.3% 1,3 butanediol aqueous solution), reflux extracting for 2 hours, filtering, loading filtrate on D101 macroporous adsorbent resin, eluting with 5 times column volume of water, 10% ethanol and 70% ethanol in sequence, collecting 70% ethanol eluate, recovering ethanol, concentrating, and drying to obtain Ligustrum quihoui extract.
According to another aspect of the present invention, there is provided a method for preparing a dragon fruit stem extract, the method comprising the steps of:
squeezing fresh stem of dragon fruit to obtain juice, filtering, diluting the filtrate with 8 times of water, loading onto D101 macroporous adsorbent resin, sequentially eluting with 5 times of column volume of water and 50% ethanol, collecting water and 50% ethanol eluate, mixing, recovering ethanol, concentrating, and drying to obtain dragon fruit stem extract.
According to another aspect of the present invention, there is provided a method for preparing a luffa tissue fluid, comprising the steps of:
cutting off the part 30 cm above the root of luffa stem, inserting the upper end of stem into a clean bottle, sealing the bottle, allowing luffa solution to flow into the bottle, collecting, aging, concentrating, filtering, and lyophilizing.
According to another aspect of the invention, the application of the traditional Chinese medicine composition in the aspects of antioxidation and whitening efficacy and the application of the traditional Chinese medicine composition in various skin care products such as facial masks, essence solutions, toilet water, skin cream and the like are provided.
It should be noted that, in the present application, the embodiments and features of the embodiments may be combined with each other without conflict. The present invention will be described in detail with reference to examples.
The present invention is described in further detail below with reference to specific examples, which are not to be construed as limiting the scope of the invention as claimed herein.
Examples
Example 1 preparation of Ligustrum quihoui extract
Taking 2Kg of Ligustrum quihoui leaves, crushing into coarse powder, adding 20 times of volume of extraction solvent (containing 0.3% betaine, 0.25% citric acid and 0.3% 1,3 butanediol aqueous solution), reflux extracting for 2 hours, filtering, loading filtrate on D101 macroporous adsorption resin, eluting with 5 times of column volume of water, 10% ethanol and 70% ethanol in sequence, collecting 70% ethanol eluate, recovering ethanol, concentrating, and drying to obtain 70.5g of Ligustrum quihoui extract. Through detection, the content of the total flavone in the ligustrum quihoui extract is 33.8%, the content of the total triterpene is 25.3%, and the content of the total phenylethanoid glycoside is 17.2%.
Example 2 preparation of dragon fruit stem extract
Squeezing 5Kg of fresh stem of dragon fruit to obtain juice, filtering, diluting the filtrate with 8 times of water, loading on D101 macroporous adsorbent resin, eluting with 5 times of column volume of water and 50% ethanol in sequence, collecting water and 50% ethanol eluate, mixing, recovering ethanol, concentrating, and drying to obtain 56.9g of dragon fruit stem extract. Through detection, the content of total polysaccharide in the dragon fruit stem extract is 35.1%, and the content of total flavone is 26.8%.
EXAMPLE 3 preparation of towel gourd tissue fluid
Cutting off 30 cm above the root of 100 luffa stems, inserting the upper end of stem into a clean bottle, sealing the bottle, allowing the luffa solution to flow into the bottle, collecting, aging, concentrating, filtering, and lyophilizing to obtain 31.9g of luffa tissue solution. Through detection, the content of total polysaccharide in the towel gourd tissue fluid is 55.3 percent.
Example 4 evaluation of antioxidant Activity of Chinese medicinal composition
HepG2 cells at 10 per well 5 cell/mL density was inoculated in a 96 well plate and the volume fraction was 5% 2 And culturing overnight under saturated humidity conditions to ensure that the cells are completely attached to the wall. Respectively setting blank group and model group (H) 2 O 2 ) The traditional Chinese medicine composition comprises a ligustrum quihoui extract group (30 mu g/ml), a dragon fruit stem extract group (30 mu g/ml), a towel gourd tissue fluid group (30 mu g/ml) and a traditional Chinese medicine composition 1 group (30 mu g/ml; ligustrum quihoui, dragon fruit stem, towel gourd 4: 5: 1), and Chinese medicinal composition 2 (30 μ g/ml; ligustrum quihoui, dragon fruit stem, luffa 1: 1), and 3 groups of traditional Chinese medicine composition (30 microgram/ml; ligustrum quihoui, dragon fruit stem, luffa 1: 2: 3), and 4 groups (30 μ g/ml; ligustrum quihoui, dragon fruit stem, luffa 2: 3: 5) and traditional Chinese medicine groupComposition 5 groups (30. Mu.g/ml; ligustrum quihoui, pitaya stem, luffa cylindrica 1: 4: 5), each group having 6 multiple holes. The medicine is pre-incubated for 10H at 37 ℃, and then H with the final concentration of 500 mu mol/L is added 2 O 2 The culture was continued for 6h, and then the cell viability was measured using the MTT method. The results are shown in Table 1:
TABLE 1 comparison of cell viability between different groups (Mean + -SD, n = 6)
Note: * Compared with the model group, P is less than 0.05.
Experimental data show that each extract group shows different degrees of antioxidation, and cells respectively subjected to extract predosing can resist cell death caused by peroxide to different degrees.
The antioxidant effect of the traditional Chinese medicine composition prepared by the three traditional Chinese medicine extracts in different proportions is greatly improved, and after the traditional Chinese medicine composition is used for pretreating cells, the cell activity is obviously higher than the sum of the effects of the respective single extracts. After the three traditional Chinese medicine extracts are mixed according to different proportions, the respective abilities of inhibiting cell death caused by peroxide are also higher than the sum of the respective effects of the corresponding respective concentrations.
The results suggest that the three traditional Chinese medicine extracts of ligustrum quihoui, dragon fruit stem and towel gourd may act on different ways or different action sites when having the antioxidation effect, the combined application of the three has a synergistic effect, and the combined application effect of the three is superior to the single use effect.
Example 5 in vitro tyrosinase inhibition evaluation of Chinese medicinal compositions
Mixing 10 μ L10% PBS buffer solution with 90 μ L tyrosinase (100U/mL), incubating at 37 deg.C for 30min, adding 100 μ L5 mg/mL-dopa solution, incubating at 37 deg.C for 30min, measuring absorbance at 475nm, and recording as A; replacing the tyrosinase solution with PBS to measure the absorbance, and recording as B; the absorbance of each group of extract (same as example 4) was measured by using the solution in place of PBS and was designated as C; the absorbance was measured by replacing PBS with each group of extract solution and replacing tyrosinase solution with PBS, and recorded as D. 10 μ L of 0.3% kojic acid was used as a positive control instead of PBS buffer. The tyrosinase inhibition was calculated in parallel 3 times according to the following formula.
Tyrosinase inhibition (%) = { [ (A-B) - (C-D) ]/(A-B) } × 100%
TABLE 2 comparison of tyrosinase inhibitory Activity between different groups (Mean + -SD, n = 6)
Note: * Compared with the model group, P is less than 0.05.
The above experimental data show that each extract group shows tyrosinase inhibitory activity of different degrees, the tyrosinase inhibitory activity of the traditional Chinese medicine composition prepared from the three traditional Chinese medicine extracts in different proportions is greatly improved, the above results suggest that the three traditional Chinese medicine extracts of ligustrum quihoui, dragon fruit stem and towel gourd have the tyrosinase inhibitory activity and a synergistic effect, and the combined application effect of the three extracts is superior to that of the single application effect.
Example 6 preparation of a facial cream containing Ligustrum quihoui, pitaya stem extract and Luffa cylindrica tissue fluid
1) Preparation of face cream
The formula of the face cream comprises: 66.1% of water, 4.0% of privet leaflet extract, 5.0% of dragon fruit stem extract, 1.0% of towel gourd tissue fluid, 4.0% of glycerol, 4.0% of polydimethylsiloxane, 3.0% of 1, 3-propylene glycol, 2.0% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 1.0% of caffeine, 1.0% of cyclodextrin, 1.0% of trehalose, 0.5% of acetyl hexapeptide, 1.76% of cyclopenta dimethyl siloxane, 0.39% of sodium hyaluronate, 0.2% of jasmine extract, 0.05% of disodium EDTA, 0.5% of p-hydroxyacetophenone, 0.15% of 1, 2-hexanediol and 0.35% of 1, 3-butanediol.
The preparation process comprises the following steps: adding water, ligustrum quihoui extract, pitaya canker extract, loofah tissue fluid, glycerol and polydimethylsiloxane into a main pot, stirring and heating to 85 deg.C for fully dissolving; then adding 1, 3-propylene glycol, hydroxyethyl acrylate/acryloyl dimethyl sodium taurate copolymer and EDTA disodium, and continuously stirring uniformly; cooling to 45 deg.C, sequentially adding the rest components, slowly stirring, inspecting, packaging, inspecting, and storing.
2) Evaluation of cream Effect
80 female volunteers 18-40 years old were recruited and randomly divided into 2 groups, and group A used Shidande every day
Ligustrum quihoui face cream, the face cream of the invention was used in group B, and the corresponding product was used 1 time per day for 15 consecutive days by volunteers in each group. Volunteers self-evaluate whitening effect using a 5-part scale: the unchanged is 0min, the improvement of 1-25% is 1 min, the improvement of 26-50% is 2 min, the improvement of 50-75% is 3 min, and the improvement of 75-100% is 4 min. And (4) safety evaluation: adverse reactions and their incidence were observed, including: itching, erythema, and the like. Adverse reaction rate = number of adverse reaction cases/total number of cases × 100%. The results are shown in Table 3:
table 3 volunteers self-evaluate hair growth (n = 40)
Experience results of volunteers containing Ligustrum quihoui, dragon fruit stem extract and towel gourd tissue liquid facial cream show that the compound extract has good whitening effect and is approved.
The foregoing is merely an example of the present invention and common general knowledge of known specific structures and features of the embodiments is not described herein in any greater detail. It should be noted that, for those skilled in the art, without departing from the present invention, several changes and modifications can be made, which should also be regarded as the protection scope of the present invention, and these will not affect the effect of the implementation of the present invention and the practicability of the patent. The scope of the claims of the present application shall be defined by the claims, and the description of the embodiments and the like in the specification shall be used to explain the contents of the claims.
The embodiments of the present invention have been described in detail, and the principles and embodiments of the present invention are explained herein using specific examples, which are provided only to help understand the method and the core idea of the present invention. Meanwhile, those skilled in the art should also be able to make modifications or variations to the embodiments and applications of the present invention based on the idea of the present invention. In view of the above, the present disclosure should not be construed as limiting the invention.
Claims (5)
1. A traditional Chinese medicine composition containing Ligustrum quihoui, dragon fruit stem extract and towel gourd tissue liquid is characterized in that the traditional Chinese medicine composition is composed of 1-10 parts of Ligustrum quihoui extract, 1-10 parts of dragon fruit stem extract and 1-10 parts of towel gourd tissue liquid.
2. The traditional Chinese medicine composition according to claim 1, characterized in that: the composition of the traditional Chinese medicine composition is further preferably composed of 4 parts of ligustrum quihoui extract, 5 parts of dragon fruit stem extract and 1 part of towel gourd tissue fluid.
3. The traditional Chinese medicine composition according to claims 1-2, characterized in that: the content of total flavone in the ligustrum quihoui extract is more than or equal to 30 percent, the content of total triterpene is more than or equal to 20 percent, and the content of total phenylethanoid glycoside is more than or equal to 10 percent; the content of total polysaccharides in the dragon fruit stem extract is more than or equal to 30 percent, and the content of total flavonoids is more than or equal to 20 percent; the content of total polysaccharide in the towel gourd tissue fluid is more than or equal to 55 percent.
4. The traditional Chinese medicine composition according to claims 1 to 3, characterized in that:
the preparation method of the privet leaflet extract comprises the following steps: taking Ligustrum quihoui leaves, crushing into coarse powder, adding 20 times volume of extraction solvent (containing 0.3% betaine, 0.25% citric acid, 0.3% 1, 3% butanediol aqueous solution), reflux extracting for 2 hours, filtering, loading filtrate on D101 macroporous adsorbent resin, eluting with 5 times column volume of water, 10% ethanol and 70% ethanol, collecting 70% ethanol eluate, recovering ethanol, concentrating, and drying to obtain Ligustrum quihoui extract.
The preparation method of the dragon fruit stem extract comprises the following steps: squeezing fresh stem of dragon fruit to obtain juice, filtering, diluting the filtrate with 8 times of water, loading onto D101 macroporous adsorbent resin, sequentially eluting with 5 times of column volume of water and 50% ethanol, collecting water and 50% ethanol eluate, mixing, recovering ethanol, concentrating, and drying to obtain dragon fruit stem extract.
The towel gourd tissue liquid is natural juice extracted from towel gourd rattan, cut off 30 cm above the root of towel gourd rattan, the upper end of the stem is inserted into a clean bottle, the bottle mouth is sealed, and the towel gourd liquid directly flows into the bottle and is prepared by collecting, aging, concentrating, filtering and freeze-drying.
5. The traditional Chinese medicine composition according to claim 1 or 2, having antioxidant and whitening effects, and being applied to various skin care products such as facial masks, essence solutions, toilet water, skin cream and the like.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211416230.7A CN115721588A (en) | 2022-11-12 | 2022-11-12 | A Chinese medicinal composition containing Ligustrum quihoui, pitaya stem extract and fructus Luffae tissue fluid, and its application in skin care product |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211416230.7A CN115721588A (en) | 2022-11-12 | 2022-11-12 | A Chinese medicinal composition containing Ligustrum quihoui, pitaya stem extract and fructus Luffae tissue fluid, and its application in skin care product |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115721588A true CN115721588A (en) | 2023-03-03 |
Family
ID=85295341
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211416230.7A Pending CN115721588A (en) | 2022-11-12 | 2022-11-12 | A Chinese medicinal composition containing Ligustrum quihoui, pitaya stem extract and fructus Luffae tissue fluid, and its application in skin care product |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115721588A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007000214A1 (en) * | 2005-06-28 | 2007-01-04 | Henkel Kommanditgesellschaft Auf Aktien | Hair or skin treating agent containing an extract of an oleaceae family plant |
| CN106924111A (en) * | 2017-03-13 | 2017-07-07 | 广州市嘉美化妆品有限公司 | A kind of light spot liquid of face |
| CN109044909A (en) * | 2018-09-12 | 2018-12-21 | 广西古瑶方药妆研发科技有限公司 | A kind of natural sponge gourd bleeding water whitening foster skin Essence |
-
2022
- 2022-11-12 CN CN202211416230.7A patent/CN115721588A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007000214A1 (en) * | 2005-06-28 | 2007-01-04 | Henkel Kommanditgesellschaft Auf Aktien | Hair or skin treating agent containing an extract of an oleaceae family plant |
| CN106924111A (en) * | 2017-03-13 | 2017-07-07 | 广州市嘉美化妆品有限公司 | A kind of light spot liquid of face |
| CN109044909A (en) * | 2018-09-12 | 2018-12-21 | 广西古瑶方药妆研发科技有限公司 | A kind of natural sponge gourd bleeding water whitening foster skin Essence |
Non-Patent Citations (1)
| Title |
|---|
| 吕述权: "小叶女贞活性部位的分离及筛选", 硕士电子期刊, pages 7 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105997815B (en) | A kind of preparation method of multifunctional beauty concentrate | |
| EP2647385A1 (en) | Tie2 ACTIVATOR, VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) INHIBITOR, ANTI-ANGIOGENIC AGENT, AGENT FOR MATURING BLOOD VESSELS, AGENT FOR NORMALIZING BLOOD VESSELS, AGENT FOR STABILIZING BLOOD VESSELS, AND PHARMACEUTICAL COMPOSITION | |
| CN107362084A (en) | A kind of facial mask containing Chinese sumac leaf extract and preparation method thereof | |
| CN104814908A (en) | Mask with effects of resisting wrinkle and tendering skin | |
| CN111012725A (en) | Asparagus skin care composition and preparation method thereof | |
| CN102274141B (en) | Herba selaginellae revival moisturizing cream and preparation method thereof | |
| CN111529413A (en) | Nicotinamide capsule mask and preparation and use methods thereof | |
| CN107998016A (en) | A kind of cosmetic material composition with freckle removing and whitening | |
| JP7429066B2 (en) | Tie2 activator, blood vessel maturation agent, blood vessel stabilizer, food and drink, and external preparation | |
| CN110507582A (en) | A kind of anti-ageing remediation composition and its preparation method and application containing composite vegetables extractive | |
| CN111297756B (en) | Essence with moistening and moisturizing and anti-allergy effects and preparation method thereof | |
| CN112168750A (en) | Preparation method of ginsenoside extract and application of ginsenoside extract in skin care product | |
| KR20170137552A (en) | Composition for improving skin condition comprising herb extracts mixture | |
| CN108578338A (en) | It is a kind of improve Chinese medicine anti-oxidation power fermentation process and its application | |
| KR101474340B1 (en) | Anti-aging cosmetic composition comprising herb ferment extract | |
| CN112137919B (en) | Application of dictyophora indusiata egg extract in preparation of external beauty and skin care products and external beauty and skin care products based on same | |
| CN102552420A (en) | Anti-ageing Chinese herbal medicine composition as well as preparation method and application for same | |
| KR101980887B1 (en) | A cosmetic composition comprising trichosanthes kirilowii extract and metaplexis japonica extract | |
| KR102004366B1 (en) | A cosmetic composition comprising centipeda minima extract | |
| CN100588389C (en) | Chinese medicine combination with whitening function and uses thereof | |
| CN107789252A (en) | A kind of Skin whitening care cosmeticses | |
| WO2019172626A1 (en) | Composition for skin moisturization and wrinkle reduction, containing extract of medicinal herb mixture as active ingredient | |
| CN115721588A (en) | A Chinese medicinal composition containing Ligustrum quihoui, pitaya stem extract and fructus Luffae tissue fluid, and its application in skin care product | |
| KR101725969B1 (en) | A cosmetic composition effective for skin whitening comprising multiple herbal extracts | |
| KR101456059B1 (en) | The cosmetic composition effective in whitening and anti-aging mainly comprised of roasted licorice extract |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |