CN1157107A - Feed additive - Google Patents
Feed additive Download PDFInfo
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- CN1157107A CN1157107A CN96101151A CN96101151A CN1157107A CN 1157107 A CN1157107 A CN 1157107A CN 96101151 A CN96101151 A CN 96101151A CN 96101151 A CN96101151 A CN 96101151A CN 1157107 A CN1157107 A CN 1157107A
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- China
- Prior art keywords
- feed addictive
- feed
- salt
- drying
- additive
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- Fodder In General (AREA)
- Feed For Specific Animals (AREA)
Abstract
The present invention discloses a feed additive. Its preparation process includes the following steps: using ethyl alcohol to extract oil cake, for example tea oil cake, at normal temp.; drying extract so as to obtain triterpene saponin, and its drying process can be spray drying or vacuum drying. Besides, said feed additive also can be made up by mixing the obtained triterpene saponin with trace element salts. Said invented bioactive additive can be fully substituted for antibiotic medicine as additive in feed, so that it can radically remove the residual of antibiotic medicine in animal product, and can raise the quality of animal product.
Description
The present invention relates to feed addictive, specifically with natural bioactivity substance as feed addictive to eliminate residual antibiotic in the livestock products, produce the livestock products of high-quality, reduce environmental pollution.
Along with the scale of modern animal husbandry, intensivization development, a large amount of antibiotic are used to prevent and treat livestock and poultry as feed addictive, promote animal growth.According to statistics, nineteen ninety, there were 2000 tons of antibiotic in China as feed addictive, and West Europe and Japan have 1350 tons and 1300 tons of antibiotic to be used for animal and fowl fodder every year respectively, and the feeding antibiotic of USA in recent years sales volume in every year is up to 10.19 hundred million dollars.And whole world feed antibiotic consumption is also with annual 3% speed increase.But the medium-term and long-term antibiotic that uses of feed not only causes the microorganisms resistance to the action of a drug, and antibiotic-resistant bacteria causes global environmental pollution, the residual direct threat human beings'health of antibiotic in livestock products by the transfer of the R factor.The World Health Organization, FAO (Food and Agriculture Organization of the United Nation) etc. attach great importance to the development of antibiotic substitute as feed addictive at present, and to natural products as the research and development of feed addictive progress to some extent already, as using microorganism fodder and Chinese herb feed additive now widely, but microorganism fodder very easily lost efficacy in the feed process, and also can only partly substitute antibiotic in feed; Chinese herb feed additive is then because of the composition complexity, the character shakiness, and result of use is not good enough and fail large-scale promotion application.
The object of the present invention is to provide a kind of novel feeding bioactive additive to substitute the antibacterials of using as additive in the present feed.
This kind feed addictive provided by the present invention is to extract active material to develop from the profuse oil cake resource of China.Wherein, feed addictive can be first with oil cake, as tea oil cake, in the normal temperature extraction, the extract drying is obtained the triterpenes saponin with ethanol (70-100% (volume ratio)).Dry run can be spray-drying or vacuum drying.
In addition, feed addictive also can be that the described triterpenes saponin that makes is mixed with micro-salt, as with triterpenes saponin and manganese, zinc salt mixes, wherein zinc salt can be a feed level zinc sulfate, manganese salt can be the feed grade manganese sulfate, and the mixed proportion of triterpenes saponin and micro-salt is 8-10 part triterpenes saponin: 0.5-2 part trace element salt (ratio of weight and number), the ratio of zinc salt and manganese salt is 1: 1 in the trace element salt.
Use the consumption of feed addictive of the present invention identical with the feed addictive of other kind with method.
The invention provides a kind of is the feeding bioactive additive of feed purification with natural oil cake, can substitute in the animal and fowl fodder antibacterials fully with it as additive, fundamentally eliminated antibiotic residual in livestock products, produce the high-quality livestock products, reduced environmental pollution, improve livestock and poultry production performance and level of human health, will think in the past that simultaneously the low oil cake of use value effectively utilizes, thereby obtained good social benefit and economic benefit.
Below from properties of product, raise benefit, to the improvement of livestock products quality, antioxidation, Study on mechanism, genetic physiology detects five aspects product of the present invention is elaborated.
(1) properties of product
This bioactive additive is the all-natural product that extracts and be developed into from plant, and for Powdered, active material is stable, and is water-soluble strong, easy to use.This product uses pollution-free, noresidue, has no side effect as feed addictive for a long time.
Year June in July, (two) 1992 to 1994, in ground plants such as Zhejiang Hangzhou, Ningbo, Fuyang, substitute antibiotic in the poultry feed fully with this bioactive additive, show at brood laying hen and industrial experimentation of the four batches 3108 plumage 49 age in days fryer, eight batches 320 11～120 age in days piglets, 600 plumages:
1. improve the livestock and poultry survival rate
Annotate: * * is P＜0.01
| Group | Fryer | Laying hen broods | Piglet | |||
| The plumage number | Survival rate % | The plumage number | Survival rate % | Number | Survival rate % | |
| Test group antibiotic group | ??1845 ??1263 | ?????95.30 ?????94.40 | ??300 ??300 | ????88.00** ????77.00 | ??160 ??160 | ??100.00 ??98.13 |
The result shows: substitute antibiotic in the animal and fowl fodder fully with this bioactive additive, the fryer survival rate improves 0.95%, and the laying hen that broods is improved 14.29% (P＜0.01), and piglet improves 1.91%.
2. improve the livestock and poultry weightening finish
| Group | Fryer | Piglet | ||||
| The plumage number | Net gain (gram/plumage) | Daily gain (gram/sky) | The plumage number | Net gain (kilogram/head) | Daily gain (gram/sky) | |
| Test group antibiotic group | ?1845 ?1263 | ???2019.8 ???1971.2 | ??41.2 ??40.2 | ??160 ??160 | ??25.17 ??22.92 | ??508.27 ??463.60 |
The result shows: test group increases by 48.6 gram/plumages than antibiotic group fryer net weight, and daily gain improves 2.49%; 2.25 kilograms/head of piglet net gain, daily gain improves 9.64%.
3. improve food conversion ratio
Annotate: * * is P＜0.05
| Group | Fryer | Piglet | ||
| The plumage number | The material anharmonic ratio | Number | The material anharmonic ratio | |
| Test group antibiotic group | ?1845 ?1263 | ?2.06∶1 ?2.26∶1 | ??160 ??160 | ????2.42∶1 ????2.54∶1 |
The result shows: this bioactive additive substitutes antibiotic, and fryer material anharmonic ratio reduces by 9.71% (P＜0.05), and the baby pig feedstuff anharmonic ratio reduces by 4.72%.
4. industrial experimentation
Begin in March, 94, we respectively ground such as Xiaoshan, Zhejiang, Ningbo, Fuyang, Jiashan, Hangzhou and Shandong with this bioactive additive substitute fully that antibiotic is produced in the livestock and poultry complete diet pellet 20,000 surplus ton industrial experimentation that the rhzomorph complete diet pellet carries out show: the every plumage of fryer obtains 0.51 yuan of net profit than containing the antibiotic complete diet pellet more, every makes a profit 5.57 yuan of piglet, the every plumage of egg fowl obtains 1.20 yuan of net profits more more.
(3) improve the livestock products quality
1. improve the nutritional labeling of meat
Studies show that: this bioactive additive all has good effect to crude fat in the chicken and amino acid content, and especially the content of threonine improves 8.38% (P＜0.05) in the chicken.
2. improve the livestock products value added
After measured: this test group improves 1.93% and 7.48% respectively than antibiotic group fryer dressing percentage and chicken total pigment content; Chicken percentage of water loss and pH value reduce by 1.37% and 2.50% respectively.This bioactive additive helps livestock products processing and storage to the good action of four meat indexs.
3. content of beary metal in the reduction meat
Measure with atomic spectrophotometer: this bioactive additive reduces by 94.41% and 38.28% respectively to heavy metal cadmium in the chicken (Cd), plumbous (Pb) content.
(4) antioxidation
Suitable this bioactive additive that adds in feed can make that acid number and peroxide value reduce by 38.79% and 31.28% (P＜0.05) respectively in the complete diet pellet, to composition easily oxidized in the feed such as crude fat and V
ASignificant protective effect is arranged.
(5) study on mechanism
1. raising body's immunity
Studies show that this bioactive additive can make fryer red blood cell C
aB acceptor rosette rate improves 21.70% (P＜0.05) than control group, to exempting to establish the compound rosette rate better effect is arranged also.
2. remove free radical and anti-sudden change
Measure with luminescence analysis, this bioactive additive is to superoxide radical (O
2) clearance rate is 94.40% (P＜0.01), hydroxy radical (0H) clearance rate is 78.19% (P＜0.01).Other there are some researches show that this bioactive additive has significant protective effect to the cell distortion that alkylating agent brings out, and antibiotic has detrimental effect to exempting to establish function.
3. antibacterial action
In vitro study shows that this bioactive additive is respectively 1.25-0.50mg/ml and 0.1563-0.0390mg/ml to Escherichia coli and salmonella inhibition inhibition concentration.
4. improve the level of body hormone, protein and enzyme
Measure with modern biochemical method, this bioactive additive makes alkali ketone content raising 25.61% (P＜0.05), The Total albumen content raising 11.08%, alkaline phosphatase enzyme level raising 19.02% in the serum of broilers.
(6) genetic toxicology detects
Measure through the sexual cell of big white mouse and body cell, this biology bosom additive of living does not have and causes prominent, teratogenesis, is safe as poultry from feed addictive for a long time.
Embodiment 1
Take by weighing tea oil cake 8000 gram, 25 ℃ of extractions three times down, combining extraction liquid carries out vacuum drying to obtain the triterpenes saponin with the ethanol of 80% (volume ratio), and bag distribution packaging promptly can be used as the feed addictive use.
Embodiment 2
Take by weighing saponin 1000 grams of embodiment 1 preparation, add 25 gram feed level zinc sulfates, 25 gram feed grade manganese sulfates, mix, get final product after the packing.
Embodiment 3
Take by weighing saponin 1000 grams of embodiment 1 preparation, add 100 gram feed level zinc sulfates, 100 gram feed grade manganese sulfates, mix, packing gets final product.
Claims (7)
1. feed addictive, its preparation method is: with oil cake with ethanol in normal temperature extraction down, the extract drying is obtained the triterpenes saponin.
2. the described feed addictive of claim 1 wherein, also comprises micro-salt is added in a certain amount of made triterpenes saponin.
3. the described feed addictive of claim 2, wherein, described micro-salt is meant that weight ratio is 1: 1 zinc salt and a manganese salt.
4. the described feed addictive of claim 3, wherein, described zinc salt is feed grade, zinc sulfate, manganese salt is the feed grade manganese sulfate.
5. the described feed addictive of claim 2, wherein, the ratio of described trace element salt and triterpenes saponin is 0.5～2: 8～10 (ratios of weight and number).
6. the described feed addictive of claim 1, wherein, described ethanol is the ethanol of 70-100% (volume ratio).
7. the described feed addictive of claim 1, wherein, described drying is vacuum drying or spray-drying.
Priority Applications (16)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96101151A CN1157107A (en) | 1996-02-14 | 1996-02-14 | Feed additive |
| CN96105034A CN1165628A (en) | 1996-02-14 | 1996-05-17 | Triterpenoid saponin extracted from tea oil cake and application as additive |
| DK96927507T DK0826303T3 (en) | 1996-02-14 | 1996-08-16 | Method of preventing animal diseases and improving the immune function of animals |
| AT96927507T ATE289747T1 (en) | 1996-02-14 | 1996-08-16 | METHOD FOR PREVENTING DISEASES IN ANIMALS AND FOR IMPROVING THE IMMUNE FUNCTIONS OF ANIMALS |
| ES96927507T ES2237773T3 (en) | 1996-02-14 | 1996-08-16 | PROCEDURE FOR PREVENTION OF DISEASES AND REINFORCEMENT OF IMMUNE FUNCTIONS OF ANIMALS. |
| RU97118686/13A RU2197260C2 (en) | 1996-02-14 | 1996-08-16 | Fodder supplement for animals and method for animal body sanitation |
| DE69634400T DE69634400T2 (en) | 1996-02-14 | 1996-08-16 | METHOD FOR PREVENTING DISEASES OF ANIMALS AND IMPROVING THE IMMUNE FUNCTIONS OF ANIMALS |
| JP52886297A JP3474198B2 (en) | 1996-02-14 | 1996-08-16 | Animal feed composition |
| PCT/CN1996/000070 WO1997029630A1 (en) | 1996-02-14 | 1996-08-16 | A method of preventing animals from diseases and improving immune function of animals |
| US08/930,754 US6007822A (en) | 1996-02-14 | 1996-08-16 | Animal feed compositions and uses of triterpenoid saponin obtained from Camellia L. plants |
| CA002224663A CA2224663C (en) | 1996-02-14 | 1996-08-16 | Animal feed compositions and uses of triterpenoid saponin obtained from camellia l. plants |
| AU67315/96A AU715733B2 (en) | 1996-02-14 | 1996-08-16 | Method of preventing animal diseases and promoting animal growth and development |
| IL12191796A IL121917A (en) | 1996-02-14 | 1996-08-16 | Animal feed comprising triterpenoid saponin obtained from camellia l. plants |
| CN96193005A CN1082337C (en) | 1996-02-14 | 1996-08-16 | Contain the fodder compound and the nourishing healthy agent of triterpenes saponin extract |
| EP96927507A EP0826303B1 (en) | 1996-02-14 | 1996-08-16 | A method of preventing animals from diseases and improving immune function of animals |
| JP2003133522A JP2004000223A (en) | 1996-02-14 | 2003-05-12 | Bioactive agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96101151A CN1157107A (en) | 1996-02-14 | 1996-02-14 | Feed additive |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1157107A true CN1157107A (en) | 1997-08-20 |
Family
ID=5116971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN96101151A Pending CN1157107A (en) | 1996-02-14 | 1996-02-14 | Feed additive |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN1157107A (en) |
| RU (1) | RU2197260C2 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106260641A (en) * | 2016-08-15 | 2017-01-04 | 林亚东 | One boar food and preparation method thereof |
| CN107960564A (en) * | 2017-12-11 | 2018-04-27 | 陈世忠 | The preparation method of aquaculture fish guano |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT6602B (en) | 2018-01-29 | 2019-03-12 | Uab "Caelum Et Mare" | The method of obtaining biologically active substances from plant raw materials by fermentation and phytobiotic additives thereof |
-
1996
- 1996-02-14 CN CN96101151A patent/CN1157107A/en active Pending
- 1996-08-16 RU RU97118686/13A patent/RU2197260C2/en not_active IP Right Cessation
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106260641A (en) * | 2016-08-15 | 2017-01-04 | 林亚东 | One boar food and preparation method thereof |
| CN107960564A (en) * | 2017-12-11 | 2018-04-27 | 陈世忠 | The preparation method of aquaculture fish guano |
| CN107960564B (en) * | 2017-12-11 | 2021-11-16 | 江苏国昌生物技术有限公司 | Preparation method of aquaculture fish guano |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2197260C2 (en) | 2003-01-27 |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |