CN115708412A - 双特异性融合蛋白 - Google Patents
双特异性融合蛋白 Download PDFInfo
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- CN115708412A CN115708412A CN202280004996.6A CN202280004996A CN115708412A CN 115708412 A CN115708412 A CN 115708412A CN 202280004996 A CN202280004996 A CN 202280004996A CN 115708412 A CN115708412 A CN 115708412A
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Abstract
本申请涉及一种双特异性融合蛋白，其包含第一结合域和第二结合域，其中所述第一结合域包含特异性结合PD‑L1的抗体，其中所述抗体包含两条抗体轻链和两条抗体重链，所述抗体轻链和所述抗体重链通过二硫键连接；所述第二结合域包含一个VEGFR1的Ig样结构域和一个VEGFR2的Ig样结构域；所述VEGFR1的Ig样结构域的N端或所述VEGFR2的Ig样结构域的N端分别与所述抗体重链的C端直接或间接连接。本申请还涉及包含所述双特异性融合蛋白的药物组合物及其制药用途。本申请所述双特异性融合蛋白可以有效安全地杀伤肿瘤细胞。
Description
PCT国内申请，说明书已公开。
Claims (43)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2021106762297 | 2021-06-18 | ||
| CN202110676229 | 2021-06-18 | ||
| PCT/CN2022/099322 WO2022262832A1 (zh) | 2021-06-18 | 2022-06-17 | 双特异性融合蛋白 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115708412A true CN115708412A (zh) | 2023-02-21 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202280004996.6A Pending CN115708412A (zh) | 2021-06-18 | 2022-06-17 | 双特异性融合蛋白 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP4357366A1 (zh) |
| CN (1) | CN115708412A (zh) |
| CA (1) | CA3223047A1 (zh) |
| TW (1) | TW202317608A (zh) |
| WO (1) | WO2022262832A1 (zh) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115109166A (zh) * | 2017-11-24 | 2022-09-27 | 浙江道尔生物科技有限公司 | 一种治疗代谢疾病的多结构域活性蛋白 |
| CN109970857B (zh) * | 2017-12-27 | 2022-09-30 | 信达生物制药(苏州)有限公司 | 抗pd-l1抗体及其用途 |
| CN113166258B (zh) | 2018-12-03 | 2023-06-20 | 宜明昂科生物医药技术（上海）股份有限公司 | 靶向pd-l1和vegf的重组蛋白 |
| CN111378044B (zh) * | 2018-12-28 | 2022-07-15 | 长春金赛药业有限责任公司 | 抗体融合蛋白、制备方法及其应用 |
| CN109627339B (zh) * | 2019-01-25 | 2022-03-15 | 北京智仁美博生物科技有限公司 | 抗人pdl1抗体及其用途 |
| WO2021003739A1 (zh) * | 2019-07-11 | 2021-01-14 | 武汉友芝友生物制药有限公司 | 四价对称双特异性抗体 |
-
2022
- 2022-06-17 CN CN202280004996.6A patent/CN115708412A/zh active Pending
- 2022-06-17 CA CA3223047A patent/CA3223047A1/en active Pending
- 2022-06-17 WO PCT/CN2022/099322 patent/WO2022262832A1/zh active Application Filing
- 2022-06-17 EP EP22824305.1A patent/EP4357366A1/en active Pending
- 2022-06-17 TW TW111122670A patent/TW202317608A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2022262832A1 (zh) | 2022-12-22 |
| CA3223047A1 (en) | 2022-12-22 |
| EP4357366A1 (en) | 2024-04-24 |
| TW202317608A (zh) | 2023-05-01 |
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