CN115697379A - 速效胰岛素组合物及其医药用途 - Google Patents

速效胰岛素组合物及其医药用途 Download PDF

Info

Publication number
CN115697379A
CN115697379A CN202180040994.8A CN202180040994A CN115697379A CN 115697379 A CN115697379 A CN 115697379A CN 202180040994 A CN202180040994 A CN 202180040994A CN 115697379 A CN115697379 A CN 115697379A
Authority
CN
China
Prior art keywords
pharmaceutical composition
arginine
insulin aspart
iloprost
insulin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202180040994.8A
Other languages
English (en)
Inventor
李金宇
孙琼
杨晓容
陈昊
王琪
卢韵
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiangsu Hengrui Medicine Co Ltd
Original Assignee
Jiangsu Hengrui Medicine Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Hengrui Medicine Co Ltd filed Critical Jiangsu Hengrui Medicine Co Ltd
Publication of CN115697379A publication Critical patent/CN115697379A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5578—Eicosanoids, e.g. leukotrienes or prostaglandins having a pentalene ring system, e.g. carbacyclin, iloprost
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

一种速效胰岛素组合物及其医药用途，该组合物包含：1)门冬胰岛素，和2)伊洛前列素和他氟前列素中的至少一种，其比现有胰岛素类似物产品的市售制剂具有更快的药代动力学，具有良好的稳定性，且对注射部位的刺激性小。

Description

PCT国内申请，说明书已公开。

Claims (16)

  1. PCT国内申请，权利要求书已公开。
CN202180040994.8A 2020-06-30 2021-06-29 速效胰岛素组合物及其医药用途 Pending CN115697379A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN2020106228765 2020-06-30
CN202010622876 2020-06-30
CN202110119199 2021-01-28
CN202110119199X 2021-01-28
PCT/CN2021/102939 WO2022002008A1 (zh) 2020-06-30 2021-06-29 速效胰岛素组合物及其医药用途

Publications (1)

Publication Number Publication Date
CN115697379A true CN115697379A (zh) 2023-02-03

Family

ID=79317446

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180040994.8A Pending CN115697379A (zh) 2020-06-30 2021-06-29 速效胰岛素组合物及其医药用途

Country Status (3)

Country Link
CN (1) CN115697379A (zh)
TW (1) TW202214292A (zh)
WO (1) WO2022002008A1 (zh)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI685348B (zh) * 2014-05-08 2020-02-21 美國禮來大藥廠 速效胰島素組合物
EP3328388B1 (en) * 2015-07-28 2023-12-27 Eli Lilly and Company A pharmaceutical preparation for improving absorption and postprandial hypoglycemic action of insulin
JO3749B1 (ar) * 2015-08-27 2021-01-31 Lilly Co Eli تركيبات إنسولين سريعة المفعول
WO2020069138A1 (en) * 2018-09-28 2020-04-02 Axsome Therapeutics, Inc. Dosage forms comprising active pharmaceutical ingredients

Also Published As

Publication number Publication date
WO2022002008A1 (zh) 2022-01-06
TW202214292A (zh) 2022-04-16

Similar Documents

Publication Publication Date Title
TWI496580B (zh) 胰島素長效調配物
CN1273187C (zh) 稳定性提高的无锌或低锌胰岛素制剂
US20180036411A1 (en) Stable Formulation of Insulin Glulisine
CN101883609A (zh) 可注射的速效胰岛素组合物
D’Souza et al. Nasal insulin gel as an alternate to parenteral insulin: formulation, preclinical, and clinical studies
EP2676677A9 (en) Highly concentrated anti-cd40 antibody pharmaceutical preparation
CN104918619B (zh) 稳定的肠胃外dnj组合物
CN104415326A (zh) 一种含有利拉鲁肽的药物制剂组合物及其制备方法
US20220133654A1 (en) Sublingual epinephrine tablets
US9468685B2 (en) Methods of preparing a liquid formulation of G-CSF
US6623732B1 (en) Pharmaceutical formulation for nasal administration
CN115697379A (zh) 速效胰岛素组合物及其医药用途
JP2021511386A (ja) 低用量の安定なグルカゴンを使用する肥満治療手術後の低血糖症の処置
EP1474164B1 (en) Use of amylin, amylin analogs and amylin derivatives to treat dyslipidemia and triglyceridemia
CN111388761B (zh) 天麻素在糖尿病环境中医用钛金属使用中的应用
JP2021506933A (ja) １型糖尿病およびインスリン使用２型糖尿病における運動誘発性低血糖の処置
KR20120022293A (ko) 산양산삼 추출물을 함유한 혈관주입용 약제학적 조성물
RU2466722C2 (ru) Противотуберкулезное средство
CN115887446A (zh) 包含右硫辛酸赖氨酸盐的组合物及其制备方法和用途
WO2021133744A1 (en) Dihydroergotamine mesylate formulations and pre-filled injectors for therapeutic delivery of the same
CN115300613A (zh) 一种含有甘精胰岛素的药物制剂组合物及其制备方法
TW201318636A (zh) 用於治療膽道狹窄或／及阻塞之ｇｌｐ－１促效劑
DE102007040932A1 (de) Flüssigformulierung von G-CSF
MXPA94003569A (en) Stable quinolone and naphthyridine premix formulations

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40088907

Country of ref document: HK