CN115697291B - 高spf皮肤清洁组合物 - Google Patents
高spf皮肤清洁组合物 Download PDFInfo
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- CN115697291B CN115697291B CN202180039496.1A CN202180039496A CN115697291B CN 115697291 B CN115697291 B CN 115697291B CN 202180039496 A CN202180039496 A CN 202180039496A CN 115697291 B CN115697291 B CN 115697291B
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Classifications
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract
本发明涉及一种个人清洁组合物,其在身体的局部表面上提供增强的防晒剂沉积。该组合物更特别地提供了这样的洗去型组合物,其确保掺入其中的防晒剂是稳定的,并且由于在表面上的高沉积,提供了高的防晒系数(SPF)。这是通过在高表面活性剂含量的组合物中两种选择的水溶性防晒剂的组合实现的。
Description
技术领域
本发明涉及一种个人清洁组合物,其向身体的局部表面上提供增强的防晒剂沉积。该组合物更特别地提供了这样的洗去型组合物,其确保掺入其中的防晒剂是稳定的,并且由于在皮肤上的高沉积,提供了高的防晒系数(SPF)。
背景技术
太阳辐射包括大约5%的紫外线(UV)辐射,其波长在200nm和400nm之间。它进一步分为三个区域:320至400纳米(UVA)、290至320纳米(UVB)和200至290纳米(UVC)。已知短时间暴露于UVA和UVB辐射导致皮肤发红和局部刺激。持续和长时间暴露可导致晒伤、黑色素瘤和皱纹的形成。还报道紫外线辐射对毛发造成严重损害。因此,人们希望保护自己的皮肤和毛发免受UVA和UVB辐射的有害影响。
已报道人们可以将各种化妆品制剂作为霜、乳液或凝胶施用到皮肤上用于防止和/或保护皮肤免受紫外线辐射的有害影响。这些化妆品组合物通常包含不同类型的有机防晒剂,尤其是能够吸收太阳光线中存在的UVA和/或UVB辐射的有机防晒剂。因此,通常掺入UVA和UVB防晒剂以便在整个UV辐射范围内提供防护。在人们外出之前将这样的保留型组合物施用在皮肤上,并保留在皮肤上直到人们下一次清洗。保留型组合物的问题是,人们必须在外出之前花一些时间将产品施用到皮肤上。除了耗时外,保留型组合物通常通过霜剂、乳液或凝胶递送。有些人可能不喜欢产品施用至皮肤上的感官特性。在皮肤上施用防晒剂的替代方法是通过洗去型产品,如皂、面部清洗或身体清洗产品,其中防晒剂被掺入到皮肤清洁产品种,并与洗涤过程同时递送至皮肤上。然而,当洗去型产品的主要目的是去除皮肤表面的污垢和油时,将防晒剂递送至皮肤上是一项极其困难的挑战,同时,洗去型产品中的活性物质也极有可能被洗掉。因此,通过洗去型产品增强活性物质的沉积是一个持续的挑战。
本发明人凭借其多年了解可用防晒剂的性质的经验;表面活性剂系统的界面科学的知识,并通过广泛的实验,找到了通过洗去型产品向皮肤提供高SPF来提供紫外线保护的解决方案。
EP1261688(Unilever,2001)公开了一种个人洗涤组合物,其沉积高水平的防晒剂(SPF>2),同时保持良好的发泡(即,相对于具有更高“油性”的防晒剂的组合物,存在泡沫随着时间的最小降解的问题)。从皂条和液体组合物中都发现增强的沉积,并且是基于所用防晒剂的溶解度或非溶解性。
本发明人已经发现,现有技术中公开的发明可以实现的SPF是有限的。如现有技术中所教导的,掺入更高量的防晒剂并不提供沉积效率的任何增强,且从而实现该SPF。
通过本发明,已经确定有必要结合两种不同类型的防晒剂(一种主要提供UVA保护,且另一种主要提供UVB保护),以获得增强的甚至协同的SPF益处。
因此,本发明的目的是消除现有技术的至少一些缺点,并提供一种与已知技术相比提供增强的SPF的个人清洁组合物。
发明内容
根据本发明的第一方面,提供了一种用于增强防晒剂在身体的局部表面上的沉积的个人清洁组合物,其包含:
(a)0.1至10重量%的水溶性UVA防晒剂;
(b)0.1至5重量%的水溶性UVB防晒剂;
(c)3至80重量%的表面活性剂;和
(d)化妆品上可接受的载体,
其中水溶性UVA防晒剂选自苯基二苯并咪唑四磺酸二钠、对苯二亚甲基二樟脑磺酸(terephthalylidene dicamphor sulfonic acid)及其混合物,和
其中水溶性UVB防晒剂选自苯基苯并咪唑磺酸、亚苄基樟脑磺酸、二苯甲酮-4及其混合物,和
其中所述UVA防晒剂和所述UVB防晒剂在25℃下在水中的溶解度高于10g/L。
本发明的第二方面涉及一种从洗去型组合物向局部表面提供改进的防晒系数的方法,包括以下步骤:
(a)用第一方面的组合物洗涤表面,其优选用水稀释;和
(b)用水冲洗所述表面,
其中防晒系数为至少8。
发明详述
通过阅读以下详细描述和所附权利要求,这些和其他方面、特征和优点对于本领域普通技术人员将变得显而易见。为避免疑问,本发明的一个方面的任何特征可用于本发明的任何其他方面。“包含”一词意指“包括”,但不一定“由…组成”或“由…构成”。换句话说,所列步骤或选项不必穷尽。应注意,以下描述中给出的实例旨在阐释本发明,而不旨在将本发明限制于这些实例本身。除非另有规定,否则本文所用的量以基于组合物总重量的重量百分比表示,并缩写为“重量%”。
除非在操作和比较实施例中,或另有明确指示的情况,否则本说明书和权利要求书中表示材料的量或反应条件、材料的物理性质和/或用途的所有数字应理解为用“大约”一词修饰。以“从x到y”格式表示的数值范围被理解为包括x和y。对于特定特征,多个优选范围以“从x到y”的格式描述时,应理解为也可以考虑组合不同端点的所有范围。
本文发现的本发明的公开内容被视为涵盖了在权利要求中发现的所有方面,如同彼此多重从属的,而与权利要求可以在没有多重从属或冗余的情况下存在的事实无关。在关于本发明的特定方面(例如本发明的组合物)公开了特征的情况下,这种公开还应被认为经过必要的修改适用于本发明的任何其他方面(例如,本发明的方法)。
本文所用的“个人清洁组合物”意指包括用于清洁哺乳动物,特别是人类的局部表面的组合物。这种组合物特别适用于身体的阳光暴露的部分。这种组合物通常是冲洗型的,这意味着组合物富含已知有助于清洁表面以使其无油和污垢的表面活性剂。该组合物通常在施用于皮肤、头皮或毛发上时用水稀释使用,之后消费者激发泡沫以确保表面上的污垢和油溶解在表面活性剂溶液的胶束中,然后用大量水冲洗身体以确保表面基本上不含该组合物。本发明的组合物可以是液体、乳液、霜剂、凝胶、洗发剂、调理剂或皂条的形式。本文中使用的“皮肤”是指包括面部和身体上的皮肤(例如颈部、胸部、背部、手臂、腋下、手、腿、臀部和头皮),尤其是其阳光暴露的部分。本发明的组合物还涉及应用于除皮肤外的人体任何其他角质基质,例如头皮和毛发,其中产品可以以提供紫外线防护的特定目的配制。本发明的独特益处在于,在清洗和冲洗过程中基本上去除组合物中的表面活性剂以及皮肤表面上的污垢和油的同时,令人惊讶观察到防晒剂的特定组合确保了它们以比通常对于洗去型产品预期的高得多的量沉积。增强的沉积导致提供高防晒系数(SPF)。根据本发明,高SPF是指SPF高于8,优选高于10的组合物。本发明中的SPF是使用透射率测量技术测量的。
本发明涉及用于增强防晒剂在皮肤上沉积的个人清洁组合物,其包含水溶性UVA防晒剂;水溶性UVB防晒剂;3至80重量%的表面活性剂;以及化妆品上可接受的载体。水溶性防晒剂,无论是UVA型还是UVB型,是指防晒剂在25℃下在水中的溶解度高于10g/L,优选高于50g/L。
用于本发明的水溶性UVB防晒剂选自苯基苯并咪唑磺酸(PBSA)、亚苄基樟脑磺酸、二苯甲酮-4及其混合物。优选地,水溶性UVB亚类是PBSA。
PBSA具有以下化学结构:
2-苯基苯并咪唑5-磺酸
PBSA,也称为恩索利唑,可作为Eusolex 232(来自Merck KGaA)商购。PBSA还以商品名Neo Heliopan Hydro(来自Symrise)、Parsol HS(来自DSM)和Sunsafe ES(来自Uniproma)获得。
亚苄基樟脑磺酸具有以下化学结构:
二苯甲酮-4(磺异苯酮)具有以下化学结构:
已知二苯甲酮-4提供UVA屏蔽功效和UVB屏蔽功效两者。然而,就本发明目的而言,二苯甲酮-4用作UVB水溶性防晒剂。
用于本发明的水溶性UVA防晒剂选自苯基二苯并咪唑四磺酸二钠(NeoheliopanAP)、对苯二亚甲基二樟脑磺酸(TDSA)及其混合物。
苯基二苯并咪唑四磺酸二钠也称为bisdisulizole二钠,其具有如下给出的化学结构:
其可作为Neo heliopan AP(来自Symrise Shanghai Ltd)或Sunsafe DPDT(来自Uniproma)商购。
对苯二亚甲基二樟脑磺酸(TDSA)具有以下结构
它也被称为Ecamsule。它可作为L’Oreal的Mexoryl SX(US4585597)或SunsafeTDSA(来自Uniproma)商购。它可以作为母体酸或其盐用于提供所需的益处。
组合物包含0.1至10重量%,优选0.25至8重量%,更优选0.5至5重量%的水溶性UVA防晒剂。该组合物包含0.1至5重量%,优选0.25至5重量%,更优选0.5至5重量%的水溶性UVB防晒剂。
用于包含在本发明组合物中的水溶性防晒剂通常以酸形式商购。当以酸形式(预中和形式),即具有磺酸基团(-SO3H)包含在组合物中时,组合物还包含中和剂以将酸形式转化为盐形式,在该形式中,已知其作为防晒剂具有活性,但Mexoryl SX除外(其可以在中和或不中和的情况下作为防晒剂)。当包括时,中和剂优选以0.05-4重量%的量包括在组合物中。中和剂优选为无机碱或有机碱。有机碱优选为胺,如三乙醇胺或二乙醇胺。本发明人已经观察到无机碱是特别优选的。优选的是碱金属氢氧化物。作为中和剂包含在本发明组合物中的最优选的金属氢氧化物是氢氧化钠或氢氧化钾。
不希望受到理论的束缚,本发明人认为仅添加单独UVB防晒剂不会提供完全的红斑防护以及UV防护,并且单一水溶性UVB防晒活性物质的沉积可以在一个浓度点下在皮肤表面上饱和,但这种限制可以通过防晒剂的结构和溶解度(其决定它们在冲洗水和清洁表面之间的分配)所选择的防晒剂的组合来超越,从而导致更高的防晒剂沉积和增强的SPF益处。
本发明的组合物包含有助于清洁作用的表面活性剂。为了实现清洁,表面活性剂以3至80重量%,优选6至80重量%,还更优选10至75重量%包括在组合物中。
皮肤清洁组合物
表面活性剂优选为阴离子表面活性剂,例如烷基硫酸盐和/或乙氧基化烷基硫酸盐表面活性剂。优选地,这些阴离子表面活性剂以1至20重量%,优选2至16重量%,更优选3至16重量%的水平存在于组合物中。优选的烷基硫酸盐是C8-18烷基硫酸酯,更优选C12-18烷基硫酸盐,优选以与增溶阳离子如钠、钾、铵或取代铵的盐的形式。优选的烷基醚硫酸盐是具有式RO(CH2CH2O)nSO3M的那些;其中R是具有8至18(优选12至18)个碳原子的烷基或烯基;n是平均值大于至少0.5,优选在1和3之间,更优选在2和3之间的数;且M是增溶阳离子,如钠、钾、铵或取代铵。实例是月桂基醚硫酸钠(SLES)。具有0.5至3,优选1至3的平均乙氧基化度的SLES是特别优选的。组合物可以包含一种或多种另外的阴离子清洁表面活性剂,其是化妆品可接受的并且适合于局部应用。
本发明的组合物优选另外包含两性表面活性剂,优选甜菜碱表面活性剂,优选烷基酰胺丙基甜菜碱表面活性剂,例如椰油酰胺丙基甜菜碱(CAPB)。在优选实施方案中,组合物包含0.1至10重量%,优选0.5至8重量%,更优选1至5重量%的甜菜碱表面活性剂。
SLES和CAPB通常组合用于洗发剂和沐浴液组合物中。或者,该组合物可以配制成皂条或液体皂沐浴液。
皂是适用于本发明组合物的个人洗涤应用的表面活性剂。皂优选为C8-C24皂,更优选C10-C20皂,最优选C12-C16皂。皂可以具有或不具有一个或多个碳-碳双键或三键。皂的阳离子可以是碱金属、碱土金属或铵。优选地,皂的阳离子选自钠、钾或铵。更优选地皂的阳离子是钠或钾。
皂可以通过皂化脂肪和/或脂肪酸获得。皂制造中通常使用的脂肪或油可以是例如牛脂、牛脂硬脂精、棕榈油、棕榈硬脂精、大豆油、鱼油、蓖麻油、米糠油、葵花籽油、椰子油、巴巴苏油、棕榈仁油等。在上述方法中,脂肪酸来源于选自椰子、米糠、花生、牛脂、棕榈、棕榈仁、棉籽、大豆、蓖麻等的油/脂肪。
典型的脂肪酸共混物由5至30%的椰子脂肪酸和70至95%的脂肪酸组成,不包括硬化米糠油。衍生自其他合适的油/脂肪如花生、大豆、牛脂、棕榈、棕榈仁等的脂肪酸也可以以其他所需比例使用。最优选的皂是月桂酸皂。当皂存在于本发明的固体形式中时,其存在量为30至90重量%,优选50至85重量%,更优选55至75重量%。当皂存在于液体形式的组合物中时,其以0.5至20重量%,优选1至10重量%存在。
或者,表面活性剂是非离子表面活性剂,例如C8-C22,优选C8-C16脂肪醇乙氧基化物,其包含1至8个环氧乙烷,该表面活性剂优选选自伯烷基硫酸盐、仲烷基磺酸盐、烷基苯磺酸盐或乙氧基化烷基硫酸盐。烷基多葡糖苷也可存在于组合物中,优选碳链长度在C6和C16之间的那些。清洁应用的液体形式中合适的表面活性剂浓度通常大于0.5重量%但小于30重量%,优选1至20重量%。在固体组合物中,表面活性剂优选以30至80重量%,优选50至80重量%存在。
本发明的组合物包含化妆品上可接受的载体。化妆品上可接受的载体优选是化妆品上可接受的辅助剂的水性溶液/分散体。水通常包含在本发明的组合物中。当组合物为固体形式,例如皂条形式时,水的量在14至25重量%,优选15至22重量%的范围内。当组合物以液体、乳液或凝胶形式配制时,水含量通常在50至95重量%的范围内,优选在60至85重量%范围内。
可用于构成本发明的皮肤清洁组合物的化妆品上可接受的载体的另外的辅助剂如下所述。
当制成皂条组合物时,其可任选地包含2至15重量%,优选4至12重量%的游离脂肪酸。游离脂肪酸是指包含烃链和与H键合的末端羧基的羧酸。合适的脂肪酸是C8-C22脂肪酸。优选的脂肪酸是C12至C18,优选主要饱和的直链脂肪酸。然而,也可以使用一些不饱和脂肪酸或羟基化饱和脂肪酸如12-羟基硬脂酸。
在皂条形式中,组合物通常包含电解质。根据本发明的电解质包括在水中基本上解离成离子的化合物。用于包括在皂制备过程中的合适电解质是碱金属盐。优选的碱金属盐包括硫酸钠、氯化钠、乙酸钠、柠檬酸钠、氯化钾、硫酸钾、碳酸钠和碱土金属的其他单盐或二盐或三盐,更优选的电解质是氯化钠、硫酸钠、柠檬酸钠、氯化钾,特别优选的电解质为氯化钠、硫酸盐、柠檬酸钠或其组合。电解质以优选0.1至6重量%,更优选0.5至6重量,甚至更优选0.5-5重量%,还更优选0.5%至3重量%,最优选1-3重量%的量包含于组合物中。
组合物优选包含多羟基醇(也称为多元醇)或多元醇的混合物。多元醇是本文中用于表示具有多个羟基(至少两个,优选至少三个)的高度水溶性化合物的术语。许多类型的多元醇是可用的,包括:相对低分子量的短链多羟基化合物,如甘油和丙二醇;糖,如山梨醇、甘露醇、蔗糖和葡萄糖;改性碳水化合物,如水解淀粉、糊精和麦芽糊精,以及聚合物合成多元醇,如聚亚烷基二醇,例如聚氧乙烯二醇(PEG)和聚氧丙烯二醇(PPG)。特别优选的多元醇是甘油、山梨醇及其混合物。最优选的多元醇是甘油。在一个优选实施方案中,本发明的条包含0至8重量%,优选1至7.5重量%的多元醇。
可使用的合适的淀粉质材料包括天然淀粉(来自玉米、小麦、大米、马铃薯、木薯等)、预胶凝化淀粉、各种物理和化学改性淀粉及其混合物。术语天然淀粉是指未经化学或物理修饰的淀粉,也称为生淀粉或天然淀粉。生淀粉可以直接使用或在条组合物的制备过程中改性以使淀粉部分或完全胶凝化。
辅助剂系统可以任选地包括不溶性颗粒,所述不溶性颗粒包含一种或多种材料。不溶性颗粒是指以固体颗粒形式存在并适用于个人洗涤的材料。优选地,存在矿物(例如无机)或有机颗粒。
不溶性颗粒不应被视为粗粒或粒状的,因此其应具有小于300微米,更优选小于100微米,最优选小于50微米的粒度。
优选的无机颗粒材料包括滑石和碳酸钙。滑石是一种硅酸镁矿物材料,具有片状硅酸盐结构,组成为Mg3Si4(OH)22,且可以水合形式获得。滑石具有板状形态,并且基本上是亲油/疏水的,即被油而不是水润湿。
碳酸钙或白垩以三种晶体形式存在:方解石、文石和球霰石。方解石的自然形态为菱面体或立方形,文石为针状或树枝状,和球霰石为球状。
其他任选的不溶性无机颗粒材料的实例包括铝酸盐、硅酸盐、磷酸盐、不溶性硫酸盐、硼酸盐和粘土(例如高岭土、瓷土)及其组合。
有机颗粒材料包括不溶性多糖,如高度交联或不溶性淀粉(例如,通过与疏水物如琥珀酸辛酯反应)和纤维素;合成聚合物,例如各种聚合物晶格和悬浮聚合物;不溶性皂及其混合物。
优选本发明的组合物包含聚合物。特别优选的是丙烯酸酯类聚合物。优选的条包含0.05至5重量%的丙烯酸酯。更优选的条包含0.01至3重量%的丙烯酸酯。丙烯酸酯聚合物的实例包括如美国专利2798053中所述的与聚烯丙基蔗糖交联的丙烯酸的聚合物和共聚物,该专利通过引用并入本文。其他实例包括聚丙烯酸酯、丙烯酸酯共聚物或碱溶胀乳液丙烯酸酯共聚物、疏水改性碱溶胀共聚物和丙烯酸的交联均聚物。此类市售聚合物的实例有:和/>Ultrez级系列。
优选地,条组合物包含0.1至25重量%,优选5至15重量%的这些矿物或有机颗粒。
遮光剂可以任选地存在于个人护理组合物中。当存在遮光剂时,清洁条通常是不透明的。遮光剂的实例包括二氧化钛、氧化锌等。当需要不透明皂组合物时可以使用的特别优选的遮光剂是乙二醇单硬脂酸酯或二硬脂酸盐,例如以月桂基醚硫酸钠中的20%溶液的形式。可选的遮光剂是硬脂酸锌。
该产品可以采取无色透明的形式,即透明皂,在这种情况下,它将不含遮光剂。
本发明的优选皂条的pH为8至11,更优选9至11。通常包含合成表面活性剂的液体形式的产品优选具有6至8的pH。
优选的组合物可以另外包含至多30重量%的有益剂。优选的有益剂包括保湿剂、润肤剂、防晒剂和抗老化化合物。在制备条的过程中,该试剂可以在适当的步骤添加。一些有益剂可以作为宏畴(macro domain)引入。
在本发明的方法中,可以以合适的量添加其它任选的成分,如抗氧化剂、香料、聚合物、螯合剂、着色剂、除臭剂、染料、酶、泡沫促进剂、杀菌剂、抗微生物剂、起泡剂、珠光剂、皮肤调理剂、稳定剂或多脂剂(superfatting agent)。优选地该成分在皂化步骤之后添加。优选向组合物中添加偏亚硫酸钠、乙二胺四乙酸(EDTA)、硼砂或亚乙基羟基二膦酸(EHDP)。
本发明的组合物可用于提供抗微生物益处。优选地包括以提供这种益处的抗微生物剂包括微动力学金属或其化合物。优选的金属是银、铜、锌、金或铝。特别优选的是银。以离子形式,它可以以任何适用的氧化态作为盐或任何化合物存在。优选的银化合物是氧化银、硝酸银、乙酸银、硫酸银、苯甲酸银、水杨酸银、碳酸银、柠檬酸银或磷酸银,在一个或多个实施方案中,氧化银、硫酸银和柠檬酸银是特别感兴趣的。在至少一个优选实施方案中,银化合物是氧化银。微动力学金属或其化合物优选以0.0001至2重量%,优选0.001至1重量%包含在组合物中。或者,本发明的组合物中可以包含精油抗微生物活性物质。可以包括的优选的精油活性物质是萜品醇、百里香酚、香芹酚(carvacol)、(E)-2(丙-1-烯基)苯酚、2-丙基苯酚、4-戊基苯酚、2-仲丁基苯酚、2-苄基苯酚、丁香酚或其组合。进一步更优选的精油活性物质是萜品醇、百里香酚、香芹酚或百里酚,最优选的是萜品醇或百里酚,理想的是两者的组合。精油活性物质优选以0.001至1重量%,优选0.01至0.5重量%包含在组合物中。
毛发护理组合物:洗发剂和调理剂:
根据本发明的另一方面,组合物可用于毛发护理。用于毛发清洁和护理的一种介质是洗发剂。本发明的洗发剂组合物通常用阴离子表面活性剂如烷基硫酸盐和/或乙氧基化烷基硫酸盐表面活性剂配制。优选地,这些阴离子表面活性剂以1至20重量%,优选2至16重量%,更优选3至16重量%的水平存在于组合物中。优选的烷基硫酸盐是C8-18烷基硫酸酯,更优选C12-18烷基硫酸盐,优选以与增溶阳离子如钠、钾、铵或取代铵的盐的形式存在。
优选的烷基醚硫酸盐是具有下式的那些:RO(CH2CH2O)nSO3M;其中R是具有8至18(优选12至18)个碳原子的烷基或烯基;n是平均值大于至少0.5,优选在1和3之间,更优选在2和3之间的数;M是增溶阳离子,如钠、钾、铵或取代铵。实例是月桂基醚硫酸钠(SLES)。
优选的乙氧基化烷基硫酸盐阴离子表面活性剂是十二烷基醚硫酸钠(SLES)。特别优选的是平均乙氧基化度为0.5至3,优选1至3的SLES。
根据本发明的洗发剂组合物可以包括一种或多种另外的阴离子清洁表面活性剂,其在化妆品上是可接受的并且适合局部施用于毛发。
本发明的组合物优选另外包含两性表面活性剂,优选甜菜碱表面活性剂,优选烷基酰胺丙基甜菜碱表面活性剂,例如椰油酰胺丙基甜菜碱。在优选实施方案中,组合物包含0.1至10重量%,优选0.5至8重量%,更优选1至5重量%的甜菜碱表面活性剂。
为了增强活性物质从本发明的组合物特别是洗发剂的沉积,其中通常包含阳离子聚合物。也在本发明中,优选的是组合物还包含0.01至2.0重量%的阳离子聚合物。阳离子聚合物优选为瓜尔胶羟丙基三甲基氯化铵。瓜尔胶聚合物主要含有半乳甘露聚糖聚合物链。根据瓜尔胶的水解和阳离子化程度,该聚合物可以各种不同的分子量和阳离子取代度获得。阳离子聚合物优选以0.04至0.5重量%,更优选0.08至0.25重量%存在于组合物中。
当通过本发明的组合物提供调理益处时,组合物被称为毛发调理剂。通常,毛发护理组合物中使用的最常见的调理剂是水不溶性的油性物质,如矿物油、天然存在的油如甘油三酯和硅氧烷聚合物。通过将油性物质沉积在毛发上导致膜的形成实现调理益处,这使得毛发在湿润时更容易梳理,并且在干燥时更易于打理。特别有用的调理剂是硅氧烷化合物,优选非挥发性硅氧烷化合物。有利地,本文的组合物可以包含一种或多种硅氧烷。硅氧烷是以分散或悬浮颗粒形式存在的调理剂。它们意图用于在用水冲洗毛发之后保持沉积在毛发上。合适的硅油可以包括聚烷基硅氧烷、聚芳基硅氧烷、聚烷基芳基硅氧烷、聚醚硅氧烷共聚物及其混合物。氨基硅氧烷通常与洗发剂组合物一起配制。氨基硅氧烷是含有至少一个伯胺、仲胺、叔胺或季铵基团的硅氧烷。也可以使用高分子量硅橡胶。另一种有用的类型是交联硅氧烷弹性体,例如二甲基硅氧烷/乙烯基/二甲基硅氧烷交联聚合物(例如,DowCorning 9040和9041)。
在毛发护理组合物中,组合物中的硅氧烷(如果存在)的量可以为约0.1至约10重量%,优选约0.1至大约8重量%,更优选约0.3至大约5重量%的范围。
组合物的pH优选等于或高于4.0,更优选在5.0至7.0的范围内。
毛发调理组合物通常包含选自阳离子表面活性剂(单独使用或混合使用)的调理表面活性剂。适用于根据本发明的调理剂组合物的阳离子表面活性剂包括十六烷基三甲基氯化铵、二十二烷基三甲基氯化铵、十六烷基氯化吡啶鎓、四甲基氯化铵、四乙基氯化铵、辛基三甲基氯化铵、十二烷基三甲基氯化铵、十六烷基三乙基氯化铵、辛基二甲基苄基氯化铵、癸基二甲基苄基氯化铵、硬脂基二甲基苄基氯化铵、二-十二烷基二甲基氯化铵、二-十八烷基二甲基氯化铵、牛脂三甲基氯化铵和二氢化牛脂二甲基氯化氨(例如,来自AkzoNobel的Arquad2HT/75)、椰油三甲基氯化铵、PEG-2-油基甲基氯化铵及其相应的氢氧化物。其他合适的阳离子表面活性剂包括具有CTFA名称季铵盐-5、季铵盐-31和季铵盐-18的那些材料。任何前述材料的混合物也可以是合适的。用于本发明的调理剂中的特别有用的阳离子表面活性剂是十六烷基三甲基氯化铵,例如作为GENAMIN CTAC从Hoechst Celanese可商购。用于本发明的调理剂中的另一种特别有用的阳离子表面活性剂是二十二烷基三甲基氯化铵,例如作为GENAMIN KDMP从Clariant可商购。再另一种优选的阳离子表面活性剂是硬脂酰胺丙基二甲基胺。
组合物中使用的最优选的阳离子表面活性剂是硬脂酰胺丙基二甲基胺、山嵛基三甲基氯化铵或硬脂基三甲基氯化铵。在本发明的调理剂中,阳离子表面活性剂的含量通常为0.1至5重量%,优选0.5至2.5重量%的范围。
本发明的毛发调理组合物优选还可以另外包含脂肪醇。脂肪醇和阳离子表面活性剂在调理组合物中的组合使用被认为是特别有利的,因为这导致层状相的形成,阳离子表面活性剂被分散在其中。
无论是作为洗发剂还是调理剂递送,毛发护理组合物通常包含抗头屑剂。用于本发明组合物的最优选的抗头屑剂是锌基抗头屑剂,优选吡啶硫酮锌。根据本发明的洗发剂组合物优选另外地或替代地包含康唑杀真菌剂。优选地,康唑杀菌剂选自酮康唑、氯咪巴唑或其混合物。唑类杀真菌剂以优选0.01至2重量%,更优选0.025至0.75重量%包含于组合物中。据信,康唑杀菌剂的存在改善吡啶硫酮锌的沉积。
本发明还涉及一种从洗去型组合物向身体局部表面提供改进的防晒系数的方法,其包括以下步骤:
(a)用第一方面的组合物洗涤表面,其优选用水稀释;和
(b)用水冲洗表面,
其中所述防晒系数为至少8。
优选地,通过该方法获得的防晒系数为至少10。
稀释时,可使用组合物量的1至20倍的水。此后可使用大量水冲洗表面以使其基本上不含组合物中的表面活性剂。
在第三方面,本发明还涉及组合物用于获得至少8,优选至少10的防晒系数的用途。
现在将借助于以下非限制性实施例来说明本发明。
实施例
实施例A-C、1、2:根据本发明的防晒剂的相互作用以提供协同的SPF益处
制备下表1中给出的组合物。使用下面给出的程序测量组合物的invitro-SPF。
将表1所示的稀释组合物施用于预湿的vitro皮肤上。然后在产品施用后立即冲洗这些vitro皮肤样品,并将其保持在暗室中干燥。干燥之后,将vitro皮肤样品暴露于紫外光,并使用Labsphere UV-2000S紫外线透射率分析仪记录透射率扫描。该扫描给出了对于给定样品作为波长(290-400nm)的函数的透射率。对于单个vitro皮肤样品,扫描四个不同的点。对3个vitro皮肤样品重复同样的操作。因此,报告的数据是12个读数的平均值。参照透射率扫描使用空白的vitro皮肤用甘油涂布在皮肤上作为对照获得。使用仪器提供的软件,透射率值用于得出SPF值。
下表1给出了作为在3个vitro皮肤样品上测量的12个读数的平均值获得的SPF值:
表1:
上表1中的数据表明,根据本发明的组合物(实施例1和2)提供了优于单独的单个组分(实施例A-C)表现出的SPF值的协同SPF值。
实施例D、3:与本发明以外的组合物相比,本发明的%UV保护
制备如下表2所示的组合物。使用以下程序测量其中组合物的%UV保护:
组合物用水稀释,然后施用于预湿的vitro皮肤上。然后在产品施用后立即冲洗vitro皮肤,并在黑暗中保持用于干燥。干燥后,将vitro皮肤暴露于紫外光,并记录透射率扫描。该扫描对于给定样品给出了作为波长(290-400nm)的函数的透射率。对于单一vitro皮肤样品,扫描四个不同的点。对3个vitro皮肤样品重复同样的操作。因此,报告的数据是12个读数的平均值。参照透射率扫描是使用空白vitro皮肤用甘油涂布在皮肤上作为对照获得的。使用UV-2000S紫外线透射率分析仪记录透射率值,并使用仪器附带的UV-2000S应用软件提取透射率数据。
保护百分比计算:
通过曲线下面积计算方法(使用Trapezoid方程)计算每个vitro皮肤样品的保护百分比。
表2:
以上表2中的数据证实了在相同的总防晒剂浓度下,包含UVA型的水溶性防晒剂和UVB型的水溶防晒剂两者的本发明的组合物(实施例3)远优于仅包含一种类型的水溶性防晒剂(实施例D)的组合物。
实施例E、F:使用二苯甲酮-4作为唯一防晒剂获得的SPF
如上面表1中的实施例所述,测量下面表3中所示组合物的SPF。
表3:
成分(重量%) | E | F |
SLES | 12 | 12 |
CAPB(30%) | 13.4 | 13.4 |
TDSA | - | - |
PBSA | - | - |
Neohelipoan AP | - | - |
二苯甲酮-4 | 1.2 | 3 |
甘油 | 2 | 2 |
KOH(85%) | 0.27 | 0.68 |
水 | 至100 | 至100 |
In vitro SPF | 2.01±0.08 | 4.85±0.78 |
Claims (8)
1.一种用于增强防晒剂在身体的局部表面上的沉积的洗去型个人清洁组合物,包含:
(a)0.1至10重量%的水溶性UVA防晒剂;
(b)0.1至5重量%的水溶性UVB防晒剂;
(c)3至80重量%的表面活性剂;和
(d)化妆品上可接受的载体,
其中所述水溶性UVA防晒剂选自苯基二苯并咪唑四磺酸二钠、对苯二亚甲基二樟脑磺酸及其混合物,和
其中所述水溶性UVB防晒剂选自苯基苯并咪唑磺酸、二苯甲酮-4及其混合物,和
其中所述UVA防晒剂和所述UVB防晒剂在25℃下在水中的溶解度高于10g/L。
2.如权利要求1所述的组合物,其中所述UVB防晒剂选自苯基苯并咪唑磺酸。
3.如权利要求1或2所述的组合物,进一步包含0.05至4重量%的中和剂。
4.如权利要求3所述的组合物,其中所述中和剂是无机碱或有机碱。
5.如权利要求1或2所述的组合物,其包含10至75重量%的表面活性剂。
6.前述权利要求中任一项所述的洗去型个人清洁组合物用于制备用于向身体的局部表面提供改进的防晒系数的方法中的产品的用途,所述方法包括以下步骤:
(a)用前述权利要求中任一项所述的组合物洗涤所述表面;和
(b)用水冲洗所述表面,
其中所述防晒系数为至少8。
7.如权利要求6所述的用途,其中在步骤(a)中该组合物用水稀释。
8.如前述权利要求1至5中任一项所述的组合物用于制备用于在施用于身体的局部表面上时获得至少8的防晒系数的产品的用途。
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PCT/EP2021/064527 WO2021245018A1 (en) | 2020-06-02 | 2021-05-31 | A high spf skin cleansing composition |
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US (1) | US11883516B2 (zh) |
EP (1) | EP4157211A1 (zh) |
JP (1) | JP2023533146A (zh) |
CN (1) | CN115697291B (zh) |
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Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1960699A (zh) * | 2004-05-24 | 2007-05-09 | 巴斯福股份公司 | 角蛋白结合多肽 |
CN101155842A (zh) * | 2005-03-18 | 2008-04-02 | 巴斯福股份公司 | 作为含水和含醇组合物的增稠剂的阳离子聚合物 |
CN104755068A (zh) * | 2012-10-24 | 2015-07-01 | 荷兰联合利华有限公司 | 防晒组合物 |
EP2939710A1 (en) * | 2014-04-29 | 2015-11-04 | Symrise AG | Method to reduce substantivity of cloth staining caused by sunscreens |
CN106038347A (zh) * | 2015-04-15 | 2016-10-26 | 强生消费者公司 | 防晒剂组合物 |
CN108367177A (zh) * | 2015-12-22 | 2018-08-03 | 莱雅公司 | 用于改进组合物的spf和流变学的高内相乳液组合物 |
CN108367176A (zh) * | 2015-12-22 | 2018-08-03 | 莱雅公司 | 基于小颗粒o/w乳剂的防晒组合物 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2798053A (en) | 1952-09-03 | 1957-07-02 | Goodrich Co B F | Carboxylic polymers |
FR2528420A1 (fr) | 1982-06-15 | 1983-12-16 | Oreal | Nouveaux 3-benzylidene camphres, leur procede de preparation et leur utilisation pour la protection contre les rayons uv |
WO2000018367A1 (en) * | 1998-09-30 | 2000-04-06 | Avon Products, Inc. | Compositions having a sunscreen for use in personal cleansing products |
US6224852B1 (en) | 1999-04-23 | 2001-05-01 | Unilever Home & Personal Care Usa | Liquid sunscreen compositions which both deposit and lather well |
US6576228B1 (en) | 2000-03-10 | 2003-06-10 | Unilever Home & Personal Care Usa Division Of Conopco, Inc. | Personal wash sunscreen compositions which deposit and lather well |
US6635702B1 (en) | 2000-04-11 | 2003-10-21 | Noveon Ip Holdings Corp. | Stable aqueous surfactant compositions |
US7666824B2 (en) | 2004-04-22 | 2010-02-23 | Kimberly-Clark Worldwide, Inc. | Liquid cleanser compositions |
NZ551366A (en) | 2004-05-24 | 2009-01-31 | Basf Ag | Keratin-binding polypeptides |
US20050265936A1 (en) | 2004-05-25 | 2005-12-01 | Knopf Michael A | Cleansing foaming sunscreen lotion |
WO2006083843A1 (en) * | 2005-01-31 | 2006-08-10 | Aquea Scientific Corporation | Additives for bodywashes |
US20080112904A1 (en) | 2005-03-08 | 2008-05-15 | Daniel Henry Traynor | Sunscreen Compositions And Methods Of Use |
DE102005039511A1 (de) | 2005-08-20 | 2007-02-22 | Clariant Produkte (Deutschland) Gmbh | Verwendung von quaternären Polysiloxanen in Reinigungs- und Pflegemitteln |
US8318659B2 (en) | 2005-11-15 | 2012-11-27 | E I Du Pont De Nemours And Company | Peptide-based organic sunscreens |
US20100209363A1 (en) * | 2009-02-19 | 2010-08-19 | The Dial Corporation | Personal cleansing composition including a structured surfactant system and a sun protection factor composition |
US8673272B2 (en) | 2009-07-27 | 2014-03-18 | Isp Investments Inc. | Ultraviolet-absorbing compounds |
US9456966B2 (en) | 2012-11-06 | 2016-10-04 | CoLabs International Corporation | Composition containing a cellulose derived capsule with a sunscreen |
US11491088B2 (en) * | 2012-11-06 | 2022-11-08 | CoLabs International Corporation | Compositions containing a capsule with a moisturizing agent |
CN111328341B (zh) | 2017-11-30 | 2021-12-17 | 高露洁-棕榄公司 | 清洁组合物及其用途 |
MX2022015098A (es) | 2020-06-02 | 2023-01-11 | Unilever Ip Holdings B V | Una composicion limpiadora con alta proteccion uv. |
-
2021
- 2021-05-31 JP JP2022573667A patent/JP2023533146A/ja active Pending
- 2021-05-31 BR BR112022023878A patent/BR112022023878A2/pt unknown
- 2021-05-31 WO PCT/EP2021/064527 patent/WO2021245018A1/en active Search and Examination
- 2021-05-31 MX MX2022015033A patent/MX2022015033A/es unknown
- 2021-05-31 CN CN202180039496.1A patent/CN115697291B/zh active Active
- 2021-05-31 US US17/925,846 patent/US11883516B2/en active Active
- 2021-05-31 EP EP21729868.6A patent/EP4157211A1/en active Pending
- 2021-05-31 CA CA3177957A patent/CA3177957A1/en active Pending
-
2022
- 2022-11-02 ZA ZA2022/11955A patent/ZA202211955B/en unknown
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1960699A (zh) * | 2004-05-24 | 2007-05-09 | 巴斯福股份公司 | 角蛋白结合多肽 |
CN101155842A (zh) * | 2005-03-18 | 2008-04-02 | 巴斯福股份公司 | 作为含水和含醇组合物的增稠剂的阳离子聚合物 |
CN104755068A (zh) * | 2012-10-24 | 2015-07-01 | 荷兰联合利华有限公司 | 防晒组合物 |
EP2939710A1 (en) * | 2014-04-29 | 2015-11-04 | Symrise AG | Method to reduce substantivity of cloth staining caused by sunscreens |
CN106038347A (zh) * | 2015-04-15 | 2016-10-26 | 强生消费者公司 | 防晒剂组合物 |
CN108367177A (zh) * | 2015-12-22 | 2018-08-03 | 莱雅公司 | 用于改进组合物的spf和流变学的高内相乳液组合物 |
CN108367176A (zh) * | 2015-12-22 | 2018-08-03 | 莱雅公司 | 基于小颗粒o/w乳剂的防晒组合物 |
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US11883516B2 (en) | 2024-01-30 |
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US20230181439A1 (en) | 2023-06-15 |
EP4157211A1 (en) | 2023-04-05 |
JP2023533146A (ja) | 2023-08-02 |
ZA202211955B (en) | 2024-04-24 |
WO2021245018A1 (en) | 2021-12-09 |
MX2022015033A (es) | 2023-01-04 |
CN115697291A (zh) | 2023-02-03 |
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