CN115669662B - Low-irritation-stability unitary peroxyacetic acid disinfectant and preparation method thereof - Google Patents
Low-irritation-stability unitary peroxyacetic acid disinfectant and preparation method thereof Download PDFInfo
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- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 title claims abstract description 194
- 239000000645 desinfectant Substances 0.000 title claims abstract description 41
- 238000002360 preparation method Methods 0.000 title abstract description 13
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract description 76
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims abstract description 74
- 239000003381 stabilizer Substances 0.000 claims abstract description 54
- 239000004094 surface-active agent Substances 0.000 claims abstract description 54
- 229960000583 acetic acid Drugs 0.000 claims abstract description 37
- 239000012362 glacial acetic acid Substances 0.000 claims abstract description 35
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims abstract description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 31
- 108010077895 Sarcosine Proteins 0.000 claims description 19
- 238000003756 stirring Methods 0.000 claims description 16
- 229940048098 sodium sarcosinate Drugs 0.000 claims description 13
- 229940061605 tetrasodium glutamate diacetate Drugs 0.000 claims description 12
- UZVUJVFQFNHRSY-OUTKXMMCSA-J tetrasodium;(2s)-2-[bis(carboxylatomethyl)amino]pentanedioate Chemical group [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CC[C@@H](C([O-])=O)N(CC([O-])=O)CC([O-])=O UZVUJVFQFNHRSY-OUTKXMMCSA-J 0.000 claims description 12
- -1 fatty alcohol sodium isethionate Chemical class 0.000 claims description 11
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 9
- 230000032683 aging Effects 0.000 claims description 8
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical group C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 7
- 229910052708 sodium Inorganic materials 0.000 claims description 7
- 239000011734 sodium Substances 0.000 claims description 7
- 229940045998 sodium isethionate Drugs 0.000 claims description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 6
- 229940043230 sarcosine Drugs 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 4
- 238000006243 chemical reaction Methods 0.000 claims description 4
- 150000002190 fatty acyls Chemical group 0.000 claims description 4
- ZUFONQSOSYEWCN-UHFFFAOYSA-M sodium;2-(methylamino)acetate Chemical compound [Na+].CNCC([O-])=O ZUFONQSOSYEWCN-UHFFFAOYSA-M 0.000 claims description 4
- MLDWGLQSBBCMMO-UHFFFAOYSA-N [Na].[Na].[Na].CNCC(=O)O Chemical compound [Na].[Na].[Na].CNCC(=O)O MLDWGLQSBBCMMO-UHFFFAOYSA-N 0.000 claims description 3
- 238000006482 condensation reaction Methods 0.000 claims description 3
- SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical compound OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 claims description 3
- FOCAUTSVDIKZOP-UHFFFAOYSA-N chloroacetic acid Chemical compound OC(=O)CCl FOCAUTSVDIKZOP-UHFFFAOYSA-N 0.000 claims description 2
- 229940106681 chloroacetic acid Drugs 0.000 claims description 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 2
- 229930195729 fatty acid Natural products 0.000 claims description 2
- 239000000194 fatty acid Substances 0.000 claims description 2
- 150000004665 fatty acids Chemical class 0.000 claims description 2
- FAIAAWCVCHQXDN-UHFFFAOYSA-N phosphorus trichloride Chemical compound ClP(Cl)Cl FAIAAWCVCHQXDN-UHFFFAOYSA-N 0.000 claims description 2
- 229940104256 sodium taurate Drugs 0.000 claims description 2
- GWLWWNLFFNJPDP-UHFFFAOYSA-M sodium;2-aminoethanesulfonate Chemical compound [Na+].NCCS([O-])(=O)=O GWLWWNLFFNJPDP-UHFFFAOYSA-M 0.000 claims description 2
- 230000002194 synthesizing effect Effects 0.000 claims description 2
- 229910021645 metal ion Inorganic materials 0.000 abstract description 28
- 238000000354 decomposition reaction Methods 0.000 abstract description 11
- 230000009920 chelation Effects 0.000 abstract description 6
- 230000002195 synergetic effect Effects 0.000 abstract description 4
- 238000012360 testing method Methods 0.000 description 17
- 230000000694 effects Effects 0.000 description 15
- 238000004659 sterilization and disinfection Methods 0.000 description 14
- 230000000052 comparative effect Effects 0.000 description 13
- 230000007797 corrosion Effects 0.000 description 12
- 238000005260 corrosion Methods 0.000 description 12
- 230000001954 sterilising effect Effects 0.000 description 11
- 229940071089 sarcosinate Drugs 0.000 description 9
- 241001465754 Metazoa Species 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- 206010040880 Skin irritation Diseases 0.000 description 7
- 231100000475 skin irritation Toxicity 0.000 description 7
- 230000036556 skin irritation Effects 0.000 description 7
- BAERPNBPLZWCES-UHFFFAOYSA-N (2-hydroxy-1-phosphonoethyl)phosphonic acid Chemical compound OCC(P(O)(O)=O)P(O)(O)=O BAERPNBPLZWCES-UHFFFAOYSA-N 0.000 description 6
- 238000004140 cleaning Methods 0.000 description 6
- 239000002184 metal Substances 0.000 description 5
- 229910052751 metal Inorganic materials 0.000 description 5
- 229920002197 Sodium polyaspartate Polymers 0.000 description 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 4
- OTTPFCJTQXRWHO-UHFFFAOYSA-N 3-(2,3-dichloroanilino)cyclohex-2-en-1-one Chemical class ClC1=CC=CC(NC=2CCCC(=O)C=2)=C1Cl OTTPFCJTQXRWHO-UHFFFAOYSA-N 0.000 description 3
- 241000700198 Cavia Species 0.000 description 3
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 239000003945 anionic surfactant Substances 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 239000013522 chelant Substances 0.000 description 3
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 description 3
- 231100000344 non-irritating Toxicity 0.000 description 3
- 239000002736 nonionic surfactant Substances 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 3
- 230000000087 stabilizing effect Effects 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 239000005725 8-Hydroxyquinoline Substances 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 229920000805 Polyaspartic acid Polymers 0.000 description 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- GIYMJJRYEFFRKQ-UHFFFAOYSA-K [Na+].[Na+].[Na+].CNCC(=O)[O-].CNCC(=O)[O-].CNCC(=O)[O-] Chemical compound [Na+].[Na+].[Na+].CNCC(=O)[O-].CNCC(=O)[O-].CNCC(=O)[O-] GIYMJJRYEFFRKQ-UHFFFAOYSA-K 0.000 description 2
- 229940024606 amino acid Drugs 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 239000003093 cationic surfactant Substances 0.000 description 2
- WOWHHFRSBJGXCM-UHFFFAOYSA-M cetyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+](C)(C)C WOWHHFRSBJGXCM-UHFFFAOYSA-M 0.000 description 2
- 239000002738 chelating agent Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000003472 neutralizing effect Effects 0.000 description 2
- 229960003540 oxyquinoline Drugs 0.000 description 2
- 108010064470 polyaspartate Proteins 0.000 description 2
- 229940051841 polyoxyethylene ether Drugs 0.000 description 2
- 229920000056 polyoxyethylene ether Polymers 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- MCJGNVYPOGVAJF-UHFFFAOYSA-N quinolin-8-ol Chemical compound C1=CN=C2C(O)=CC=CC2=C1 MCJGNVYPOGVAJF-UHFFFAOYSA-N 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- 229910000975 Carbon steel Inorganic materials 0.000 description 1
- 235000013162 Cocos nucifera Nutrition 0.000 description 1
- 244000060011 Cocos nucifera Species 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 206010058679 Skin oedema Diseases 0.000 description 1
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 125000003368 amide group Chemical group 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 239000010962 carbon steel Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 1
- 239000007938 effervescent tablet Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 125000001165 hydrophobic group Chemical group 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- MEFBJEMVZONFCJ-UHFFFAOYSA-N molybdate Chemical compound [O-][Mo]([O-])(=O)=O MEFBJEMVZONFCJ-UHFFFAOYSA-N 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000009972 noncorrosive effect Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 229960004838 phosphoric acid Drugs 0.000 description 1
- 239000002985 plastic film Substances 0.000 description 1
- 229920006255 plastic film Polymers 0.000 description 1
- 229920000259 polyoxyethylene lauryl ether Polymers 0.000 description 1
- ZNNZYHKDIALBAK-UHFFFAOYSA-M potassium thiocyanate Chemical compound [K+].[S-]C#N ZNNZYHKDIALBAK-UHFFFAOYSA-M 0.000 description 1
- 229940116357 potassium thiocyanate Drugs 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 231100000430 skin reaction Toxicity 0.000 description 1
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
- 239000004289 sodium hydrogen sulphite Substances 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 229940048086 sodium pyrophosphate Drugs 0.000 description 1
- LADXKQRVAFSPTR-UHFFFAOYSA-M sodium;2-hydroxyethanesulfonate Chemical compound [Na+].OCCS([O-])(=O)=O LADXKQRVAFSPTR-UHFFFAOYSA-M 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 239000006076 specific stabilizer Substances 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 229940104261 taurate Drugs 0.000 description 1
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- PBYZMCDFOULPGH-UHFFFAOYSA-N tungstate Chemical compound [O-][W]([O-])(=O)=O PBYZMCDFOULPGH-UHFFFAOYSA-N 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a low-stimulus-stability unitary peroxyacetic acid disinfectant and a preparation method thereof, belonging to the technical field of disinfectants, and comprising the following components in percentage by weight: 10-60% of hydrogen peroxide, 8-50% of glacial acetic acid, 0-2% of concentrated sulfuric acid, 1-5% of surfactant, 1-2% of stabilizer and the balance of water. The stabilizer selected by the invention and the surface active agent with chelating property have synergistic effect, so that metal ions can be chelated firmly, the stabilizer and the metal ions are combined through chelation, coordination and the like before the metal ions react with the peroxyacetic acid, and the decomposition of the peroxyacetic acid caused by the metal ions is avoided, thereby increasing the stability of the peroxyacetic acid, prolonging the shelf life of the peroxyacetic acid and prolonging the shelf life of the peroxyacetic acid to 2 years.
Description
Technical Field
The invention relates to the technical field of disinfectants, in particular to a low-irritation-stability unitary peroxyacetic acid disinfectant.
Background
The peracetic acid is a widely applied high-efficiency broad-spectrum disinfectant, has the effect of killing various microorganisms such as bacteria, viruses, fungi, spores and the like, has the characteristic of high-efficiency disinfection in a short time with low concentration and no residue, has wide related fields including livestock, medical use and the like, and is an ideal high-efficiency, broad-spectrum and environment-friendly disinfectant. There are three types of peroxyacetic acid currently on the market: ① is binary high-concentration peracetic acid, which is generally divided into A, B parts and needs to be prepared at present when in use to maintain the stability of the peracetic acid. ② is monobasic low-concentration peracetic acid, the content of which is about 5%, the use is convenient, but the stability of the product is mostly less than 6 months. ③ is high-concentration peracetic acid, and the concentration of the peracetic acid can reach 16-23%. Although the existing unitary peracetic acid overcomes the defect of inconvenient use of binary peracetic acid, the peracetic acid is easily influenced by factors such as temperature, light, organic matters, alkali, various metal ions and the like, so that the content of the peracetic acid is rapidly reduced, and the stability of the active ingredients of the product is mostly less than 6 months.
The addition of the stabilizer is an important means for solving the stability problem of the peroxyacetic acid, and the existing peroxyacetic acid stabilizer comprises 8-hydroxyquinoline, phosphoric acid, sodium pyrophosphate, salicylic acid, potassium thiocyanate, organic phosphonic acid, EDTA, hydroxyethylidene diphosphonic acid (HEDP) and the like, and particularly has the best effect when 8-hydroxyquinoline and hydroxyethylidene diphosphonic acid are used. However, quinoline is toxic and has certain corrosiveness, and is unsafe and limited to use. A formulation and method for immediate rapid generation of peroxyacetic acid disinfectant as disclosed in publication No. CN110150279a, wherein a surfactant CTAC (cetyltrimethylammonium chloride) is used for the purpose of improving cleaning effect. The weak alkaline low corrosion peroxyacetic acid effervescent tablet disinfectant disclosed in publication No. CN106879593A, wherein the added surfactant is nonionic surfactant amino acid surfactant, fatty alcohol polyoxyethylene ether, alkylphenol polyoxyethylene ether, anionic surfactant sodium dodecyl benzene sulfonate, sodium dodecyl sulfate and the like, but the surfactant is added only for improving the cleaning effect. A solid-state peracetic acid long-acting sterilization powder disclosed in publication No. CN110934141A and a preparation method thereof are disclosed, wherein an acetyl carrier and a surfactant are added to form a peracetic acid carrier, so that the purpose of slow release and long-term stability is achieved. Publication No. CN114097783A discloses a peroxyacetic acid disinfectant and a preparation method thereof, wherein the peroxyacetic acid disinfectant is also a combination of a stabilizer and a cationic surfactant, and the cationic surfactant in the technical scheme is only used for improving the sterilization effect. The stable peroxyacetic acid disinfectant disclosed in publication No. CN102090393A adopts tungstate and molybdate as stabilizers, and the added surfactant is an isomeric alcohol ether nonionic surfactant such as isomeric polyoxyethylene lauryl ether, isomeric polyoxyethylene undecyl ether, isomeric polyoxyethylene tridecyl ether and the like, and the nonionic surfactants are only used for reducing the surface tension and improving the wettability, so that the sterilizing or cleaning effect is improved.
In summary, the surfactant added in the peroxyacetic acid disinfectant in the prior art is mainly used as a bactericide or improves the cleaning effect, and has less influence on the stability of the monoperoxyacetic acid.
Disclosure of Invention
The invention provides a low-irritation stability monobasic peroxyacetic acid disinfectant, which can improve the stability of monobasic peroxyacetic acid and prolong the shelf life of monobasic peroxyacetic acid through the synergistic effect of a specific surfactant and a stabilizer.
In order to achieve the above object, the present invention is achieved by the following technical scheme:
The low-irritation-stability monobasic peroxyacetic acid disinfectant comprises the following components in percentage by weight: 10-60% of hydrogen peroxide, 8-50% of glacial acetic acid, 0-2% of concentrated sulfuric acid, 1-5% of surfactant, 1-2% of stabilizer and the balance of water.
Preferably, the low-irritation-stability monobasic peroxyacetic acid disinfectant comprises the following components in percentage by weight: 10-60% of hydrogen peroxide, 8-20% of glacial acetic acid, 0.01-1% of concentrated sulfuric acid, 1-3% of surfactant, 1-2% of stabilizer and the balance of water.
Further, the stabilizer is one or more of tetra sodium glutamate diacetate, trisodium methylglycine diacetate, urea and sodium polyaspartate.
Further, the surfactant is one or more of fatty alcohol sodium isethionate, N-fatty acyl sodium sarcosinate and coconut amide sodium methyl taurate.
Further, the mass concentration of the hydrogen peroxide is 10% -60%.
Further, the mass concentration of the glacial acetic acid is not less than 99%.
In the process of storing and using the peracetic acid, the main factor influencing the stability of the peracetic acid is metal ions, and the existence of the metal ions can catalyze the decomposition of the peracetic acid so as to accelerate the reduction speed of the content of the peracetic acid. The added surfactant is a chelating surfactant, and has chelating property and surface activity, and hydrophobic groups are arranged on the surface. The stabilizer is also chelate, the stabilizer and the surfactant are mutually matched, and the stabilizer and the metal ions are combined through chelation, coordination and the like before the metal ions react with the peroxyacetic acid, so that the decomposition of the metal ions on the peroxyacetic acid is avoided, and the stability of the peroxyacetic acid is improved.
The invention also discloses a preparation method of the low-stimulus-stability monobasic peroxyacetic acid disinfectant, which comprises the following steps: mixing hydrogen peroxide with water, adding acetic acid and concentrated sulfuric acid, stirring at normal temperature, sequentially adding surfactant and stabilizer under stirring for 15-30min, and aging to obtain stable low-concentration peracetic acid.
Further, the curing is as follows: curing at 25deg.C for 2-3 days or at 54 deg.C for 24 hr. Curing is carried out at this temperature.
The low-irritation stability unitary peroxyacetic acid disinfectant and the preparation method thereof have the beneficial effects that:
(1) The stabilizer selected by the invention and the surface active agent with chelating property have synergistic effect, so that metal ions can be chelated firmly, the stabilizer and the metal ions are combined through chelation, coordination and the like before the metal ions react with the peroxyacetic acid, and the decomposition of the metal ions to the peroxyacetic acid is avoided, thereby increasing the stability of the peroxyacetic acid, prolonging the shelf life of the peroxyacetic acid and prolonging the shelf life of the peroxyacetic acid to 2 years.
(2) The surfactant adopted by the invention can reduce the surface tension, improve the wettability and the permeability, and increase the contact time of the peroxyacetic acid and the disinfection surface, thereby improving the disinfection effect.
(3) The raw materials of the invention have low content of concentrated sulfuric acid, low corrosiveness and irritation, and the process is easy for large-scale production.
(4) According to the invention, through the specific formula components, the dosage of the catalyst concentrated sulfuric acid and the reaction temperature, the content of the peroxyacetic acid can reach 5% only by curing for 1-2 days, the curing time period is good, the stability is good, the dangerous coefficient caused by high-concentration peroxyacetic acid is reduced, and the generation speed of peroxyacetic acid is ensured.
Detailed Description
In order that the manner in which the invention may be better understood, a more particular description of the invention will be rendered by reference to specific embodiments thereof which are illustrated in the appended drawings. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
The low-irritation-stability monobasic peroxyacetic acid disinfectant comprises the following components in percentage by weight: 10-60% of hydrogen peroxide, 8-50% of glacial acetic acid, 0-2% of concentrated sulfuric acid, 1-5% of surfactant, 1-2% of stabilizer and the balance of water.
In another disinfectant, the disinfectant comprises the following components in percentage by weight: 10-60% of hydrogen peroxide, 8-20% of glacial acetic acid, 0.01-1% of concentrated sulfuric acid, 1-3% of surfactant, 1-2% of stabilizer and the balance of water.
Stabilizing agent
The stabilizer is one or more of tetrasodium glutamate diacetate, trisodium methylglycine diacetate, urea and sodium polyaspartate. Preferably, tetrasodium glutamate diacetate or trisodium methylglycinate diacetate are chelate, and can be chelated with metal ions to stabilize and migrate the metal ions, so that the decomposition of peracetic acid is avoided, and the stability of peracetic acid is ensured.
Tetra sodium glutamate diacetate (GLDA) is a green chelating agent, is environment-friendly and easy to degrade, has excellent chelating performance, and can adapt to the condition that the pH value is acidic and neutral.
Trisodium methylglycinate diacetate (MLDA), a green degradable chelating agent, is environmentally friendly, has a fast degradation rate, is non-irritating, and is non-corrosive.
Sodium polyaspartate, which can stabilize zinc metal ions and has dispersibility to iron ions. After the polyaspartic acid is combined with the surfactant, metal ions can be stabilized or dispersed into the surfactant by the polyaspartic acid, so that the contact chelation of the surfactant is facilitated on the surface of the liquid, the contact of the metal ions with the peroxyacetic acid is avoided, and the stability of the peroxyacetic acid is improved.
Surface active agent
The surfactant of the invention is one or more of fatty alcohol sodium isethionate, N-fatty acyl sodium sarcosinate and cocoamidomethyl sodium taurate. The surfactant disclosed by the invention not only has good wettability and bactericidal property, but also improves the bactericidal cleaning effect. The surfactant also has certain chelating property, can chelate metal ions, avoids the decomposition of the metal ions on the peroxyacetic acid, and improves the storage stability of the peroxyacetic acid.
The fatty alcohol sodium isethionate, preferably sodium laurinol sodium isethionate, is obtained by condensation reaction of lauryl alcohol with ethylene oxide and sodium bisulphite. The sodium laurinol isethionate has the advantages that the sodium laurinol isethionate has a strong chelating performance due to the action between a plurality of hydroxyl groups and sulfonic groups, and can be combined with metal ions through chelation, coordination and the like by matching with a stabilizer before the metal ions react with the peroxyacetic acid, so that the decomposition of the peroxyacetic acid caused by the metal ions is avoided, and the stability of the peroxyacetic acid is improved.
N-fatty acyl sarcosinate sodium salt
The N-fatty acyl sarcosine sodium is synthesized by the following method:
s1: synthesizing sarcosine and chloroacetic acid under the condition of sodium hydroxide to obtain a sodium sarcosinate solution; the specific equation is:
s2: the fatty acid reacts with phosphorus chloride to obtain fatty acyl chloride, and the specific reaction equation is as follows:
s3: the sodium sarcosinate solution and the fatty acyl chloride solution are subjected to condensation reaction to obtain N-fatty acyl sodium sarcosinate, and the specific equation is as follows:
The N-fatty acyl sodium sarcosinate adopted by the invention is N-lauroyl sodium sarcosinate, has good wettability and has high-efficiency sterilization effect and cleaning effect. Meanwhile, the N-fatty acyl sarcosine sodium has the functions of chelating coordination and solubilization, and can be combined with a stabilizer through chelation, coordination and the like before the metal ions react with the peroxyacetic acid, so that the decomposition of the peroxyacetic acid caused by the metal ions is avoided, and the stability of the peroxyacetic acid is improved.
The cocoamidomethyl taurate is an amino acid type surfactant, has good self stability, contains a hydrophilic amino acid structure, has very small skin irritation, and can reduce the skin irritation caused by other components. The chelating effect on metal ions is formed between the amide group and the sulfonic group in the cocoamidomethyl taurine sodium salt, and the cocoamidomethyl taurine sodium salt has stronger chelating performance. The stabilizer is used together with the organic acid, so that the decomposition of metal ions to the peroxyacetic acid can be effectively prevented, and the stability of the peroxyacetic acid is improved.
Example 1
A low-irritation stability monobasic peroxyacetic acid disinfectant comprises the following components in percentage by weight: 50% of hydrogen peroxide, 10% of glacial acetic acid, 1% of concentrated sulfuric acid, 1% of surfactant fatty alcohol sodium isethionate, 1% of stabilizer sodium polyaspartate and the balance of water. Wherein the concentration of hydrogen peroxide is 55%; the glacial acetic acid concentration is greater than 99%.
The preparation method of the unitary peroxyacetic acid disinfectant comprises the following steps: mixing hydrogen peroxide, glacial acetic acid and concentrated sulfuric acid, stirring, adding stabilizer and surfactant, adding water, stirring for 15-20min, and aging at 25deg.C for 2-3 days.
Example 2
A low-irritation stability monobasic peroxyacetic acid disinfectant comprises the following components in percentage by weight: 50% of hydrogen peroxide, 10% of glacial acetic acid, 1% of concentrated sulfuric acid, 1.5% of surfactant N-fatty acyl sarcosinate, 1.5% of stabilizer tetrasodium glutamate diacetate and the balance of water. Wherein the concentration of hydrogen peroxide is 55%; the glacial acetic acid concentration is greater than 99%.
The preparation method of the unitary peroxyacetic acid disinfectant comprises the following steps: mixing hydrogen peroxide, glacial acetic acid and concentrated sulfuric acid, stirring, adding stabilizer and surfactant, adding water, stirring for 15-20min, and aging at 25deg.C for 2-3 days.
Example 3
A low-irritation stability monobasic peroxyacetic acid disinfectant comprises the following components in percentage by weight: 55% of hydrogen peroxide, 13% of glacial acetic acid, 1% of concentrated sulfuric acid, 2% of surfactant cocoamidomethyl taurine sodium, 1.5% of stabilizer methyl glycine disodium diacetate and the balance of water. Wherein the concentration of hydrogen peroxide is 55%; the glacial acetic acid concentration is greater than 99%.
The preparation method of the unitary peroxyacetic acid disinfectant comprises the following steps: mixing hydrogen peroxide, glacial acetic acid and concentrated sulfuric acid, stirring, adding stabilizer and surfactant, adding water, stirring for 15-20min, and aging at 25deg.C for 2-3 days.
Example 4
A low-irritation stability monobasic peroxyacetic acid disinfectant comprises the following components in percentage by weight: 60% of hydrogen peroxide, 8% of glacial acetic acid, 0.1% of concentrated sulfuric acid, 2% of surfactant N-fatty acyl sarcosinate, 1.5% of stabilizer tetrasodium glutamate diacetate and the balance of water. Wherein the concentration of hydrogen peroxide is 55%; the glacial acetic acid concentration is greater than 99%.
The preparation method of the unitary peroxyacetic acid disinfectant comprises the following steps: mixing hydrogen peroxide, glacial acetic acid and concentrated sulfuric acid, stirring, adding stabilizer and surfactant, adding water, stirring for 15-20min, and aging at 25deg.C for 2-3 days.
Example 5
A low-irritation stability monobasic peroxyacetic acid disinfectant comprises the following components in percentage by weight: 55% of hydrogen peroxide, 20% of glacial acetic acid, 0.5% of concentrated sulfuric acid, 3% of surfactant N-fatty acyl sarcosinate, 2% of stabilizer tetrasodium glutamate diacetate and the balance of water. Wherein the concentration of hydrogen peroxide is 55%; the glacial acetic acid concentration is greater than 99%.
The preparation method of the unitary peroxyacetic acid disinfectant comprises the following steps: mixing hydrogen peroxide, glacial acetic acid and concentrated sulfuric acid, stirring, adding stabilizer and surfactant, adding water, stirring for 15-20min, and aging at 25deg.C for 2-3 days.
Example 6
A low-irritation stability monobasic peroxyacetic acid disinfectant comprises the following components in percentage by weight: 55% of hydrogen peroxide, 13% of glacial acetic acid, 1% of concentrated sulfuric acid, 1% of surfactant N-fatty acyl sarcosinate, 1% of stabilizer tetrasodium glutamate diacetate and the balance of water. Wherein the concentration of hydrogen peroxide is 55%; the glacial acetic acid concentration is greater than 99%.
The preparation method of the unitary peroxyacetic acid disinfectant comprises the following steps: mixing hydrogen peroxide, glacial acetic acid and concentrated sulfuric acid, stirring, adding stabilizer and surfactant, adding water, stirring for 15-20min, and aging at 25deg.C for 2-3 days.
Comparative example 1
55% Of hydrogen peroxide, 13% of glacial acetic acid, 1% of concentrated sulfuric acid, 2% of stabilizer tetrasodium glutamate diacetate and the balance of water.
Comparative example 2
55% Of hydrogen peroxide, 13% of glacial acetic acid, 1% of concentrated sulfuric acid, 2% of surfactant N-fatty acyl sarcosinate and the balance of water.
Comparative example 3
55% Of hydrogen peroxide, 13% of glacial acetic acid, 1% of concentrated sulfuric acid, 1% of surfactant N-fatty acyl sarcosinate, 1% of stabilizer EDTA-2Na and the balance of water.
Comparative example 4
55% Of hydrogen peroxide, 13% of glacial acetic acid, 1% of concentrated sulfuric acid, 1% of surfactant N-fatty acyl sarcosinate, 1% of stabilizer HEDP and the balance of water.
Comparative example 5
55% Of hydrogen peroxide, 13% of glacial acetic acid, 1% of concentrated sulfuric acid, 1% of surfactant N-fatty acyl sarcosinate, 0.5% of stabilizer EDTA-2Na, 0.5% of HEDP and the balance of water.
Comparative example 6
55% Of hydrogen peroxide, 13% of glacial acetic acid, 1% of concentrated sulfuric acid, 1% of surfactant sodium dodecyl benzene sulfonate, 1% of stabilizer tetrasodium glutamate diacetate and the balance of water.
Comparative example 7
55% Of hydrogen peroxide, 13% of glacial acetic acid, 1% of concentrated sulfuric acid, 1% of surfactant sodium dodecyl sulfate, 1% of stabilizer tetrasodium glutamate diacetate and the balance of water.
Comparative example 8
55% Of hydrogen peroxide, 13% of glacial acetic acid, 1% of concentrated sulfuric acid, 1% of surfactant sodium dodecyl benzene sulfonate, 0.5% of stabilizer EDTA-2Na, 0.5% of HEDP and the balance of water.
Blank group
55% Of hydrogen peroxide, 13% of glacial acetic acid, 1% of concentrated sulfuric acid and the balance of water.
Peroxyacetic acid stability test
The solutions of examples 1 to 6 and comparative example 1 were subjected to measurement of the content of peracetic acid according to the method of detection in the "sterilization technical Specification", and the results obtained are shown in the following table:
TABLE 1 short term accelerated test results at 60℃
TABLE 2 accelerated test results at 40℃
The test rule in the test of the stability of the disinfection products in the specification of disinfection technology, 2.2.3, and the evaluation of the result of the accelerated test method is that the effective components are reduced by 10 percent is not in compliance with the requirements. If the sample is stored for three months at 37 ℃, the content reduction rate of the sterilizing effective components is less than or equal to 10 percent, and the storage effective period can be positioned for 2 years; the reduction rate of the sterilizing effective components is less than or equal to 10 percent after the sterilizing effective components are stored for 14 days at the temperature of 54 ℃, and the storage effective period can be positioned for 1 year.
As can be seen from the stability test data in the above tables 1-2, the solutions obtained in examples 1-6 in the accelerated test were stable in peroxyacetic acid content, and all were within the acceptable range, indicating that the peroxyacetic acid solutions prepared according to the invention were good in stability.
Accelerating for 14 days at 60 ℃ is equivalent to 1 year of quality guarantee at normal room temperature, and the decomposition rate of the peracetic acid is below 8% and the stability is good as can be seen from table 1.
It can be seen from example 6 and comparative examples 1 and 2 that the stabilizer has a large influence on the decomposition rate of peracetic acid, and the presence of the surfactant can improve the stability of the stabilizer to peracetic acid.
As can be seen from comparative examples 3 to 5, the stabilizer used in the present invention is a specific stabilizer, and has a better stabilizing effect than the conventional chelate-type stabilizer,
It can be seen from comparative examples 6 to 7 that the stabilizer has a large influence on the stability of peracetic acid, but the surfactant of the present invention has a synergistic effect on the stabilizer. Whereas conventional anionic surfactants have less effect on the stability of peroxyacetic acid.
As can be seen from comparative example 8, the conventional anionic surfactant, in combination with the conventional stabilizer, has a certain stabilizing effect but a smaller stabilizing effect. The specific surfactant and the stabilizer are adopted to cooperate with each other, so that the stability of the peroxyacetic acid can be greatly improved.
Test of disinfection Effect
Strain testing: candida albicans (ATCC 10231), escherichia coli (ATCC 8099), staphylococcus aureus (ATCC 6538), salmonella (FSCC 215009).
Detecting the concentration of a sample: example 6 peracetic acid was formulated as a 5% peracetic acid solution.
Detection basis (disinfection technical Specification) (2002 edition)
The experimental method comprises the following steps: taking 0.5ml of all the sterile growth gradient test tubes, adding 4.5ml of neutralizing agent, uniformly mixing, taking 1ml of neutralizing agent, pouring into a flat plate, and culturing at 36 ℃ for 24 hours, wherein the minimum sterile growth concentration on the flat plate is the minimum sterilization concentration; the data obtained are shown in table 3:
TABLE 3 sterilizing effect
As can be seen from Table 3, the present invention has excellent sterilizing effect.
Skin irritation test
Sample: example 6 20-fold dilution of peracetic acid disinfectant;
Animals: guinea pigs, supplied by the biological technology company limited, tai Ping, hunan, laboratory animals produced license numbers: SCXK (Xiang) 2020-0005.
Environment: the temperature is 23-26 ℃ and the relative humidity is 56-59%.
The inspection method comprises the following steps: 3 white guinea pigs with the weight of 250-300g are subjected to haircutting at two sides of the back of the guinea pigs for 24 hours before the test, the haircutting areas at the left side and the right side are about 3cm multiplied by 3cm, the right side is used as an application area, and the left side is used as a blank control area. Measuring 0.5ml of the test substance, uniformly coating on the skin of the test animal coating area, covering with a layer of non-irritating plastic film, and fixing with non-irritating adhesive tape for 4h. After application for 4 hours, the application area was rinsed with warm water to remove residues. Local skin responses were observed 1h, 24h and 48h after removal of the test subjects, and the scores of 3 animals were added at time points, divided by the number of animals, to obtain the integrated mean (stimulation index) of skin stimulation responses at different time points. The highest skin irritation index was taken and the test article was rated for its skin irritation intensity on animals according to tables 2-12 of the "disinfection Specification" (2002 edition).
After 4 hours of administration, the local skin of the animal in the application area is washed by warm water, and the skin erythema, edema and other abnormal reactions in the application area and the skin in the control area are not observed in all the tested animals for 1 hour, 24 hours and 48 hours. The highest skin irritation index was 0. The test results obtained are shown in Table 4;
TABLE 4 results of one complete skin irritation test
Metal corrosion performance test
Metal corrosiveness experiments were performed according to the disinfection technical Specification (2002 edition). The metal sheet is selected from stainless steel, carbon steel, copper and aluminum, and is soaked in the disinfectant for 72 hours, and the metal corrosion rate is calculated. The test results obtained are shown in Table 5:
TABLE 5 Metal Corrosion Properties
Comparison of corrosive classification criteria: corrosion rate <0.0100, substantially no corrosion; the corrosion rate is 0.0100-0.100:mild corrosion; the corrosion rate is 0.100-1.00:moderate corrosion; the corrosion rate is more than 1.00, and the corrosion is serious.
Reference herein to "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment may be included in at least one embodiment of the invention. The appearances of such phrases in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments. Those of skill in the art will explicitly and implicitly appreciate that the embodiments described herein may be combined with other embodiments.
Finally, it should be noted that: the embodiment of the invention is disclosed only as a preferred embodiment of the invention, and is only used for illustrating the technical scheme of the invention, but not limiting the technical scheme; although the invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art will understand that; the technical scheme recorded in the various embodiments can be modified or part of technical features in the technical scheme can be replaced equivalently; such modifications and substitutions do not depart from the spirit and scope of the corresponding technical solutions.
Claims (5)
1. A low-irritation stability monobasic peroxyacetic acid disinfectant, which is characterized in that: comprises the following components in percentage by weight: 10-60% of hydrogen peroxide, 8-50% of glacial acetic acid, 0-2% of concentrated sulfuric acid, 1-5% of surfactant, 1-2% of stabilizer and the balance of water;
The stabilizer is tetrasodium glutamate diacetate or trisodium methylglycine diacetate;
The surfactant is one or more of fatty alcohol sodium isethionate, N-fatty acyl sodium sarcosinate and cocoamidomethyl sodium taurate;
the fatty alcohol sodium isethionate is sodium laurinol isethionate;
The N-fatty acyl sodium sarcosinate is N-lauroyl sodium sarcosinate; the N-fatty acyl sarcosine sodium is synthesized by the following method:
s1: synthesizing sarcosine and chloroacetic acid under the condition of sodium hydroxide to obtain a sodium sarcosinate solution; the specific equation is:
；
s2: the fatty acid reacts with phosphorus chloride to obtain fatty acyl chloride, and the specific reaction equation is as follows:
；
s3: the sodium sarcosinate solution and the fatty acyl chloride solution are subjected to condensation reaction to obtain N-fatty acyl sodium sarcosinate, and the specific equation is as follows:
。
2. the low stimulus stability, monoperoxyacetic acid disinfectant of claim 1 wherein: the mass concentration of the hydrogen peroxide is 10% -60%.
3. The low stimulus stability, monoperoxyacetic acid disinfectant of claim 1 wherein: the mass concentration of the glacial acetic acid is not less than 99%.
4. A method of preparing a low stimulus stability monoperoxyacetic acid disinfectant according to any one of claims 1-3, wherein: the method comprises the following steps: mixing hydrogen peroxide with water, adding acetic acid and concentrated sulfuric acid, stirring at normal temperature, sequentially adding surfactant and stabilizer under stirring for 15-30 min, and aging to obtain stable low-concentration peracetic acid.
5. The method for preparing the low-irritation-stability monobasic peroxyacetic acid disinfectant according to claim 4, which is characterized in that: the curing is as follows: curing at 25deg.C for 2-3 days or at 54 deg.C for 24 hr.
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