CN115666535B - 含有脂质纳米颗粒的颗粒及其生产方法 - Google Patents

含有脂质纳米颗粒的颗粒及其生产方法 Download PDF

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Publication number
CN115666535B
CN115666535B CN202180038195.7A CN202180038195A CN115666535B CN 115666535 B CN115666535 B CN 115666535B CN 202180038195 A CN202180038195 A CN 202180038195A CN 115666535 B CN115666535 B CN 115666535B
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China
Prior art keywords
particles
liquid
physiologically active
lipid nanoparticles
acid
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CN202180038195.7A
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English (en)
Chinese (zh)
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CN115666535A (zh
Inventor
森谷树
尾上诚良
佐藤秀行
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Ricoh Co Ltd
University of Shizuoka
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Ricoh Co Ltd
University of Shizuoka
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
CN202180038195.7A 2020-05-20 2021-05-18 含有脂质纳米颗粒的颗粒及其生产方法 Active CN115666535B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020-088154 2020-05-20
JP2020088154 2020-05-20
PCT/JP2021/018751 WO2021235425A1 (ja) 2020-05-20 2021-05-18 脂質ナノ粒子を含有する粒子及びその製造方法

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CN115666535A CN115666535A (zh) 2023-01-31
CN115666535B true CN115666535B (zh) 2024-06-18

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Country Link
US (1) US12508223B2 (https=)
EP (1) EP4169509A4 (https=)
JP (1) JPWO2021235425A1 (https=)
KR (1) KR20230005989A (https=)
CN (1) CN115666535B (https=)
CA (1) CA3183691A1 (https=)
WO (1) WO2021235425A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023178334A1 (en) * 2022-03-18 2023-09-21 Genentech, Inc. Nano-suspensions and amorophous solid dispersions of hydrophobic agents and methods of use thereof

Citations (3)

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JP2005511629A (ja) * 2001-11-20 2005-04-28 アドバンスト インハレーション リサーチ，インコーポレイテッド 持続作用生成物送達用組成物
JP2011137031A (ja) * 1998-11-20 2011-07-14 Oban Energy Ltd リン脂質で安定された分散し得るミクロ粒子
JP2017160188A (ja) * 2016-03-04 2017-09-14 株式会社リコー 微粒子の製造方法

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JPS5932993B2 (ja) 1979-06-25 1984-08-13 株式会社明電舎 多相インバ−タの電圧制御装置
JPH08133986A (ja) 1994-11-02 1996-05-28 Mitsubishi Chem Corp リポソーム凍結乾燥製剤
JP4228230B2 (ja) 2004-11-08 2009-02-25 独立行政法人産業技術総合研究所 リポソーム懸濁液の製造方法及びリポソームを用いた用途
JP4647506B2 (ja) 2006-01-27 2011-03-09 株式会社リコー 粒子特にトナー粒子の製造方法、トナー粒子の製造装置及びトナー
JP5055154B2 (ja) 2007-03-20 2012-10-24 株式会社リコー トナーの製造方法、トナーの製造装置及びトナー
US10973763B2 (en) 2011-06-17 2021-04-13 Berg Llc Inhalable pharmaceutical compositions
JP6953414B2 (ja) 2016-01-20 2021-10-27 フラリー パウダーズ エルエルシーＦｌｕｒｒｙ Ｐｏｗｄｅｒｓ，Ｌｌｃ 親油性成分を含む吸入に好適な分散性の噴霧乾燥粉末を製造する方法
JP7105179B2 (ja) 2018-11-26 2022-07-22 株式会社トーキン 基板
JP7546344B2 (ja) 2018-02-09 2024-09-06 株式会社リコー 粒子の製造方法、粒子の製造装置、及び粒子
CN110123634A (zh) 2018-02-09 2019-08-16 株式会社理光 颗粒的制造方法，颗粒的制造装置，以及颗粒
JP7092974B2 (ja) 2018-03-26 2022-06-29 株式会社リコー 樹脂微粒子の製造方法、及び樹脂微粒子の製造装置
JP7192232B2 (ja) 2018-03-30 2022-12-20 株式会社リコー 医薬品用粒子の製造装置、及び医薬品用粒子の製造方法
EP3829644A4 (en) * 2018-07-30 2022-05-04 Ricoh Company, Ltd. PROCESS FOR MANUFACTURING PARTICLES AND PARTICLE AND MEDICATION MANUFACTURED BY THE PROCESS
JP7503781B2 (ja) * 2018-07-30 2024-06-21 株式会社リコー 粒子の製造方法、並びに、それにより製造された粒子及び医薬
JP2020152674A (ja) 2019-03-20 2020-09-24 株式会社リコー 難水溶性化合物の可溶化物の製造方法
WO2020261619A1 (ja) 2019-06-26 2020-12-30 株式会社リコー 医薬組成物
EP3989940A1 (en) 2019-06-26 2022-05-04 Ricoh Company, Ltd. Instantly soluble particle and method for producing the same
JP2021028305A (ja) 2019-08-09 2021-02-25 株式会社リコー 粒子、医薬組成物、及び粒子の製造方法
JP7600528B2 (ja) 2020-03-16 2024-12-17 株式会社リコー 粒子の製造方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011137031A (ja) * 1998-11-20 2011-07-14 Oban Energy Ltd リン脂質で安定された分散し得るミクロ粒子
JP2005511629A (ja) * 2001-11-20 2005-04-28 アドバンスト インハレーション リサーチ，インコーポレイテッド 持続作用生成物送達用組成物
JP2017160188A (ja) * 2016-03-04 2017-09-14 株式会社リコー 微粒子の製造方法

Also Published As

Publication number Publication date
US20230210767A1 (en) 2023-07-06
KR20230005989A (ko) 2023-01-10
EP4169509A4 (en) 2024-06-05
CA3183691A1 (en) 2021-11-25
EP4169509A1 (en) 2023-04-26
CN115666535A (zh) 2023-01-31
WO2021235425A1 (ja) 2021-11-25
JPWO2021235425A1 (https=) 2021-11-25
US12508223B2 (en) 2025-12-30

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