CN115634166A - Composition with inverse piezoelectric effect and application thereof in cosmetics - Google Patents
Composition with inverse piezoelectric effect and application thereof in cosmetics Download PDFInfo
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Abstract
The invention belongs to the technical field of cosmetics, and particularly relates to an inverse piezoelectric effect composition and application thereof in cosmetics. The skin care composition comprises components such as a humectant, an emulsifier, a skin feel regulator, lecithin, a preservative, tocopherol acetate, sodium hyaluronate, a plant extract, nicotinamide, caffeine and the like, wherein the skin care composition is electrified with micro current of 20-500 muA to obtain the inverse piezoelectric effect composition, the components are scientifically compounded, are easy to absorb and penetrate into a dermis layer, and cooperate with stimulation of the micro current on the skin to promote blood circulation, and under the synergistic effect of the components, excellent skin care effects (wrinkle resistance, compactness, whitening and the like) are realized.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to an inverse piezoelectric effect composition and application thereof in cosmetics.
Background
The inverse piezoelectric effect refers to a phenomenon that an alternating electric field is applied to a crystal to cause mechanical deformation of the crystal.
At present, the absorption effect of the emulsion of cosmetics is poor, and how to improve the absorption effect of the emulsion is always the problem to be solved in the field.
Secondly, there are currently a variety of techniques for stimulating skin with various micro-currents to produce beneficial effects, such as those known in the literature "Military Medical Research,2014, 1. In particular, as known from "Homeopathy,2012, 101, 147-153", when a micro-current is introduced into the skin, collagen fibers become thicker and the skin density increases, thus bringing about an effect of increasing skin elasticity. According to "Clin ortho, 1982, 171, 264-272", the uptake of amino acids is enhanced when a microcurrent is introduced.
However, various side effects of the simple micro-current in stimulating the facial skin (especially for people with sensitive skin) are gradually manifested, such as inflammation, itching, red heat and the like.
Therefore, the need for a special skin care composition to achieve skin care effect in combination with micro-current is a problem to be solved in the current field.
Disclosure of Invention
In order to solve the technical problems, the invention constructs an emulsion similar to liquid crystal under the inspiration of a liquid crystal structure thinking, utilizes lecithin in cooperation with a fatty alcohol emulsifier, wraps emulsion liquid beads to be layered by the characteristics of phospholipid, but the structure is unstable, and realizes the oriented ordered arrangement of the emulsion by utilizing an electric field under the inspiration of an inverse piezoelectric effect, so that the emulsion has a better absorption effect to a great extent, and promotes blood circulation in cooperation with the stimulation of micro-current to skin, and the excellent technical effect is realized under the synergistic effect of the two.
Specifically, the technical scheme of the invention is as follows:
the composition with the inverse piezoelectric effect is obtained by applying micro-current of 20-500 mu A to a skin care composition, and the skin care composition comprises the following components in percentage by weight:
further, the plant extract is at least one of seed fat of Elaeis guineensis (Astrocaryum mururu), palmitoleyl alcohol, seed fat of Theobroma grandiflora (Theobroma GRANDIFLORUM), root extract of Zingiber OFFICINALE (Zingiber OFFICINALE), bisabolol, aescin, root extract of Ruscus ACULEATUS (Ruscus ACULEATUS), leaf extract of CENTELLA ASIATICA (CENTELLA ASIATICA), and flower extract of CALENDULA OFFICINALIS (Calentula OFFICINALIS).
Further, the emulsifier is at least one of C12-20 alkyl glucoside, cetyl alcohol and stearyl alcohol.
Further, the preservative is p-hydroxyacetophenone.
Further, the humectant is at least one of jojoba (Simmondsia CHINENSIS) seed oil, glycerin, 1, 3-butanediol, 1, 2-hexanediol, and 1, 2-pentanediol.
Further, the skin feel modifier is at least one of cyclopentadimethicone and dimethicone.
The invention provides a method for preparing the inverse piezoelectric effect composition, which comprises the following steps:
(1) Heating water to 80-85 ℃, adding the humectant, the skin feel modifier and the tocopherol acetate in the heating process, and dissolving to obtain a water phase;
(2) Heating lecithin, emulsifier and sodium hyaluronate to 70-90 ℃ to obtain an oil phase;
(3) Keeping the temperature at 80-85 ℃, stirring the homogenized water phase at 15000-20000 rpm, adding the oil phase, and continuously stirring and homogenizing for 5-10 min;
(4) Adjusting the stirring speed to 100-1000 rpm, cooling to 40-45 ℃, adding the plant extract, the nicotinamide, the caffeine and the preservative, and uniformly stirring to obtain the skin care composition;
(5) And introducing micro-current of 20-500 mu A into the skin care composition to obtain the composition with the inverse piezoelectric effect.
Further, the skin care composition is electrified with micro-current of 20-500 mu A by using an eye massager to obtain the composition with the inverse piezoelectric effect;
the eye massager comprises a shell 1 with an inner cavity, at least two massage devices 2, a liquid storage device 4 and a control structure;
an opening is formed in the middle of the shell 1, so that the liquid storage device 4 is detachably embedded in the opening;
the massage device 2 comprises a metal ball 21, a heating sheet 22, a first conductive module 33, a second conductive module 32 and a conduit, wherein the metal ball 21 is embedded in the middle of the heating sheet 22, the heating sheet 22 is fixedly connected with the massage device 2, the conduit is arranged in the massage device 2, one end of the conduit is connected with the liquid storage device 4, and the other end of the conduit is adsorbed and abutted to the metal ball 21;
1 inner chamber of casing sets up control structure, control structure includes circuit mainboard 3, power 3 and little current control module 35, 3 electric connection power 3 of circuit mainboard and little current control module 35, little current control module 35 is through first electrically conductive module 33 electric connection metal ball 21, generate heat piece 22 through second electrically conductive module 32 electric connection circuit mainboard 3.
The invention also provides application of the inverse piezoelectric effect composition in skin external products, including but not limited to cosmetics, including but not limited to face cream, facial mask, toner, emulsion and gel.
The invention has the following beneficial effects:
the ingredients of the inverse piezoelectric effect composition are scientifically compounded, are easy to absorb, penetrate into a dermis layer, are matched with the stimulation of micro-current to skin, and promote blood circulation, and under the synergistic effect of the ingredients, excellent skin care effects (wrinkle resistance, compactness, whitening and the like) are realized.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this specification, are included to provide a further understanding of the invention, and are incorporated in and constitute a part of this specification, illustrate exemplary embodiments of the invention and together with the description serve to explain the invention and not to limit the invention.
FIG. 1 is a bar graph of wrinkle scores for subjects at regimen A;
FIG. 2 is a bar graph of F4 scores for subjects at regimen A;
FIG. 3 is a comparison of protocol A subject 088VISIA before and after analysis (from left to right, pre-test, 14d, 28d);
FIG. 4 is a comparison graph of the presence and absence of a 001VISIA assay in a subject under regimen A (from left to right, pre-test, 14d, 28d);
FIG. 5 is a comparison of the pre-and post-analysis results of protocol A subject 006VISIA (from left to right, pre-test, 14d, 28d);
FIG. 6 is a side view of the eye massager;
FIG. 7 is a rear view of the eye massager;
FIG. 8 is a perspective view of an eye massager;
FIG. 9 is a schematic view of the eye massager with its internal structure disassembled;
in the figure, a shell 1, a massage device 2, a liquid storage device 4, a metal ball 21, a heating sheet 22, a first conductive module 33, a second conductive module 32, a circuit board 3, a power supply 3, a micro-current control module 35 and a switch 34 are provided.
Detailed Description
The invention is described below by means of specific embodiments. Unless otherwise specified, all technical means used in the present invention are well known to those skilled in the art. In addition, the embodiments should be considered illustrative, and not restrictive, of the scope of the invention, which is defined solely by the claims. It will be apparent to those skilled in the art that various changes or modifications in the components and amounts of the materials used in these embodiments can be made without departing from the spirit and scope of the invention.
Example 1
The inverse piezoelectric effect composition is obtained by electrifying a skin care composition with 100 mu A micro-current, and the skin care composition consists of the following components in percentage by weight:
the preparation method of the inverse piezoelectric effect composition comprises the following steps:
(1) Heating water to 85 deg.C, adding glycerol, 1, 3-butanediol, polysiloxane, isononyl isononanoate, jojoba (SIMMONDSIA CHINENSIS) seed oil, and tocopherol acetate during heating process, and dissolving to obtain water phase;
(2) Heating cetyl alcohol, hydrogenated lecithin, polyglycerol-10 laurate and sodium hyaluronate to 80 ℃ to obtain an oil phase;
(3) Keeping the temperature at 85 ℃, stirring and homogenizing the water phase at 20000rpm, adding the oil phase, and continuously stirring and homogenizing for 5-10 min;
(4) Adjusting stirring speed to 500rpm, cooling to 40 deg.C, adding Ruscus ACULEATUS (Ruscus ACULEATUS) root extract, herba Centellae (CENTELLA ASIATICA) leaf extract, herba Sidae Rhombifoliae (CALENDULA OFFICINALIS) flower extract, rhizoma Zingiberis recens (Zingiber OFFICINALE) root extract, bisabolol, nicotinamide, caffeine, and p-hydroxyacetophenone, and stirring to obtain skin care composition;
(5) And introducing 100 muA micro-current into the skin care composition to obtain the composition with the inverse piezoelectric effect.
Example 2
The composition with the inverse piezoelectric effect is obtained by applying 200 mu A micro-current to a skin care composition, and the skin care composition consists of the following components in percentage by weight:
the preparation method of the inverse piezoelectric effect composition comprises the following steps:
(1) Heating water to 80 deg.C, adding glycerol, 1, 3-butanediol, 1, 2-hexanediol, 1, 2-pentanediol, polysiloxane, isononyl isononanoate, jojoba (SIMMONDSIA CHINENSIS) seed oil, and tocopherol acetate during heating process, and dissolving to obtain water phase;
(2) Heating stearyl alcohol, hydrogenated lecithin, polyglycerol-10 laurate and sodium hyaluronate to 80 ℃ to obtain an oil phase;
(3) Keeping the temperature at 80 ℃, stirring the homogenized water phase at 18000rpm, adding the oil phase, and continuously stirring and homogenizing for 5-10 min;
(4) Adjusting stirring speed to 800rpm, cooling to 45 deg.C, adding palmitoleic alcohol, aescin, herba Sidae Rhombifoliae (Calendilla OFFICINALIS) flower extract, theobroma grandiflora (Theobroma GRANDIFLORUM) seed fat, elaeagnus mururi (Astrocaryum mururu) seed fat, nicotinamide, caffeine, and p-hydroxyacetophenone, and stirring to obtain skin care composition;
(5) And introducing 200 muA of micro-current into the skin care composition to obtain the composition with the inverse piezoelectric effect.
Example 3
An eye massager, wherein a microcurrent is introduced into the skin care composition prepared in the embodiment 1 or the embodiment 2 to obtain the composition with the inverse piezoelectric effect in the embodiment 1 or the embodiment 2;
the eye massager comprises: a shell 1 with an inner cavity, two massage devices 2, a liquid storage device 4 and a control structure;
an opening is formed in the middle of the shell 1, the liquid storage device 4 is detachably embedded in the opening, the liquid storage device 4 contains a skin care composition, and when the skin care composition is used up, a new liquid storage device 4 can be replaced;
the external of the shell 1 is fixedly connected with two massage devices 2, when the massage devices 2 are not in contact with a human body, a current path is not formed between the massage devices 2, each massage device 2 comprises a metal ball 21, a heating sheet 22, a first conductive module 33, a second conductive module 32 and a catheter (not shown in the figure), the metal balls 21 are embedded in the middle of the heating sheet 22, the metal balls 21 can roll in any direction, the heating sheet 22 is fixedly connected with the massage devices 2, the catheters are arranged in the massage devices 2, one end of each catheter is connected with the liquid storage device 4, the other end of each catheter is abutted to the metal balls 21, a skin care composition in the liquid storage device 4 is attached to the metal balls 21 through the catheters, and when the skin care composition is used, the skin care composition is rolled by the metal balls 21 and coated on eyes;
1 inner chamber of casing sets up control structure, control structure includes circuit mainboard 3, power 3 and little current control module 35, 3 electric connection power 3 of circuit mainboard and little current control module 35, little current control module 35 control power 3 sends 20 ~ 500 mu A's electric current, little current control module 35 is through first conductive module 33 electric connection metal ball 21, makes the two poles of the earth of metal ball 21 between the massage device 2 connection power 3 respectively, when contacting skin, forms little current path on skin, makes the circular telegram of skin care composition form inverse piezoelectric effect composition, piece 22 that generates heat is through second conductive module 32 electric connection circuit mainboard 3, generates heat by switch 34 control, and piece 22 that generates heat is because the separation of metal ball 21, not direct contact skin surface, and the discomfort of contact metal ball 21 has been avoided in the temperature sense of production.
The eye massager disclosed by the invention can be used for promoting absorption by directionally and orderly arranging the skin care product composition prepared in the embodiment 1 or the embodiment 2, and simultaneously can be used for acting microcurrent stimulation on skin, so that the collagen fibers are thickened, the skin density is improved, the skin elasticity is enhanced, and wrinkles are eliminated, and meanwhile, the skin care product composition can be used for relieving skin inflammation possibly caused by electric stimulation, and the skin inflammation and the collagen fibers are synergistic and can not be eliminated.
Human body wrinkle resistance and tightening efficacy evaluation test
The test consignment is Shandong Zhongan biosafety detection Co.
1. Subjective evaluation of subjects
Test samples and methods of use: the skin care composition prepared in example 1 was used with an eye massager;
testing quantity and specification: 38 bottles × 10ml;
sample color and state: light yellow cream;
the test method comprises the following steps: subjective evaluation, questionnaire survey and instrument test;
the method comprises the following steps: evaluation of cosmetic efficacy (XII) Consumer's use test "daily chemical industry" 6 months 2021, vol 51, no 6
And (3) testing results: after 28 days of use, 90% of the subjects agreed that the product was light and thin 90% agreed that the product was spread evenly: 90% of the subjects agreed that the product was strong: 90% of the subjects approved the product to be non-sticky: 90% of subjects identified improvement of eye skin laxity after use: 93% of subjects accepted that the eye skin was more elastic after use: 87% of subjects agreed to be more tight on the posterior eye skin: 93% of subjects identified improvement of fine lines in the eye skin after use: after 90% of the subjects agree to improve the dry lines of the eye skin, the skin care composition of example 1 is matched with an eye massage apparatus (100 muA) to be used for 2 cases that the subjects do not have red itch and inflammation of the skin and the subjects only use the eye massage apparatus to be electrified for 100 muA massage to have red itch and inflammation of the skin.
2. Objective quantitative test
(1) Purpose of testing
The anti-wrinkle and firming effects of the product are verified by performing instrument tests and self-evaluation after 100 people use the product for 28 consecutive days by adopting random and single breeding tests.
(2) Basis of test
Method for testing anti-wrinkle efficacy of TIZHCA006-2018 cosmetic
Method for testing tightening efficacy of T/TDCA003-2021 cosmetics
Method for testing influence of T/ZHCA005-2019 cosmetics on skin elasticity
Cosmetic efficacy evaluation (XII) -Consumer use test
(3) Test sample
Scheme A: 10ml of the skin care product composition prepared in the example 1 (batch 20220815) is used with an eye massager, and the skin is gently massaged by electrifying the instrument for 100 muA until the skin is completely absorbed;
scheme B: 10ml of the skin care composition prepared in example 1 (batch 20220815) was applied as-is.
Scheme C: only the eye massager is electrified for 100 muA massage for the same time.
(4) Subject information
TABLE 1 Subjects information
| Options for | Total number of people | For male | Woman | Age range | Average age (year of age) |
| The number of subjects | 100 | 38 | 62 | 24-50 | 28.3 |
| Number of available persons | 90 | 35 | 55 | 24-50 | 28.8 |
(5) Group entry criteria
All subjects included in the group met the following inclusion and exclusion criteria:
1) And (3) inclusion standard:
(1) male or female volunteers 18-60 years old meeting the requirements of the test:
(2) agreement to strictly follow the test flow throughout the test:
(3) a copy of the informed consent and product privacy agreement has been read, signed and received;
(4) there is skin laxity and dry line fine lines/wrinkles.
2) Exclusion criteria:
(1) patients with psoriasis, eczema, atopic dermatitis, etc. have a history of skin diseases:
(2) the patients who take the medicines or foods with the alleged anti-wrinkle and tightening effects within nearly 3 months:
(3) the test part is subjected to medical and aesthetic treatment or beauty treatment modes such as chemical stripping, laser, pulsed light, moisturizing effect and the like within nearly 3 months;
(4) the working environment is inevitable for long-time sunlight exposure;
(5) women in lactation, good woman, and pregnancy preparing;
(6) patients suffering from asthma or other chronic respiratory diseases undergoing therapy
(7) Those with high constitutional sensitivity;
(8) those suffering from immune diseases;
(9) those receiving anti-cancer chemotherapy within approximately 6 months;
the (R) affects the judgment of the test result in the skin special test part due to scar, pigment, shrinkage of diamond, port wine stain or other blemishes.
(6) Test instrument
CK Cutomer dual MPA580, VISIA7, germany.
(7) Test environment
The environmental requirements are as follows: temperature: 21.0 ℃ ± 1.0 ℃: humidity: 50% +/-10%.
(8) Test procedure
1) Test procedure
(1) On the day of testing, subjects visited, and qualified subjects were instructed to perform the trial and signed an informed consent:
(2) the subjects cleaned their faces using a laboratory-supplied facial cleansing product and then rested for 30 minutes in a resting waiting area in a constant temperature and humidity room; during the period, water and beverage can not be drunk, the test part is exposed, and the test part is kept relaxed.
(3) The test person performed the subject facial area test:
(4) the test person distributes the test samples, which are used by the subjects with the eye massager for 28 consecutive days according to the instructions for use of the samples:
(5) the test person measured the wrinkle score, F4 value, at the test area 14 days and 28 days after the subject used the product at D14 and D28, respectively, and the subject filled out a self-assessment questionnaire.
(6) The test personnel recovered the test samples and questionnaire.
2) Life time of test sample
And 28 days.
3) Observation and test site
Eyes are formed.
4) Test schedule
TABLE 2 test Schedule
5) Observation and test items
Wrinkle score, F4 value.
Wrinkle score: the smaller the value of the comprehensive index reflecting the size, area and density of the wrinkles, the less obvious the wrinkles are;
f4[ mm · s ] values: reflecting the skin firmness, the smaller the value, the more firm the skin.
6) Data statistical analysis method
And carrying out statistical analysis on each measured value by using SPSS software, carrying out significance test of normal distribution by using Kolmogorov-SmimovTest, wherein the significance level is selected to be 0.05, carrying out t test if the measured value is in normal distribution, carrying out Wicoxon test on abnormal distribution, and taking 0.05 as the significance difference level alpha.
7) Subject self assessment sub-standard
Scores 7 were very similar, scores 6 were more similar, scores 5 were somewhat similar, scores 4 were neither different nor objectionable, scores 3 were somewhat different, scores 2 were more similar, and scores 1 were very different.
A score of > 5 (i.e. selection of very good + comparative good + somewhat good) indicates that the subject agrees to the option.
(9) Adverse events
All adverse reactions of the skin such as redness, prickling, itching, burning and the like which occur during the use of the product should be recorded, and the serious adverse reactions should be reported in time.
Grading of adverse skin reactions is judged according to adverse skin reaction grading standards in human trial test safety evaluation specified in 2015 edition of technical Specification for cosmetic safety:
grade 0 (no skin reaction):
grade 1 (pale erythema on skin):
grade 2 (erythema, infiltration and pimple on skin)
Grade 3 (erythema, edema, pimples, and water marks on the skin);
grade 4 (erythema, edema and scarification of skin)
The adverse reaction is judged according to the following three-level standard:
mild-subjects were tolerated without special treatment, and did not affect normal life of subjects:
moderate-subjects are intolerant, requiring product withdrawal or special treatment, affecting the normal life of the subject:
severe-preventing normal life, the product needs to be stopped immediately or treated urgently.
(10) Test results
TABLE 3 wrinkle score
"+" indicates that p is less than or equal to 0.05; "+" indicates that 0.001. Ltoreq. P < 0.01; "x" indicates p < 0.001;
rate of change = [ post-test wrinkle score-pre-test wrinkle score ] 100%
From the above table and fig. 1, it can be seen that 28 days after sampling the sample, the wrinkle score in the test area was significantly reduced (P < 0.01) compared to the pre-sample baseline.
TABLE 4 F4[ mm ] parameter
"+" indicates that p is less than or equal to 0.05; "+" indicates that 0.001. Ltoreq. P < 0.01; "x" indicates p < 0.001;
rate of change = [ F4[ mm s ] after test ] -F4 [ mm s ] before test ]) F4[ mm s ] before test ] 100%
From the above table and fig. 2, it can be seen that the F4 value of the test area was significantly reduced (P < 0.01) after 28 days of trial use of the sample compared to the pre-trial basis.
(11) Conclusion
The test result of the test subject population shows that:
after the test product is used for 28 days, the wrinkle value of a test area of the scheme A is remarkably reduced (P < 0.01) and the F4 value is remarkably reduced (P < 0.01) (figures 3-5), and the wrinkle value and the F4 value of the test area of the scheme B and the scheme C are not remarkably reduced, so that the skin care composition prepared by the test example 1 has good effects of resisting wrinkles and tightening by being matched with an eye massager, and has a synergistic effect, but the simple direct smearing effect is poor, and the phenomenon of adverse reaction is caused by the simple use of the eye massager.
Adverse events, table below:
TABLE 5 adverse events
Claims (10)
1. The composition with the inverse piezoelectric effect is characterized by being obtained by applying micro-current of 20-500 mu A to a skin care composition, wherein the skin care composition comprises the following components in percentage by weight:
2. the composition having inverse piezoelectric effect as in claim 1 wherein the plant extract is at least one of palmetto palm (astrocarylum mururu) seed fat, palmitoleyl alcohol, THEOBROMA grandiflora (THEOBROMA grandiflora) seed fat, ginger (ZINGIBER OFFICINALE) root extract, bisabolol, aescin, butcher's broom (RUSCUS ACULEATUS) root extract, CENTELLA ASIATICA (CENTELLA ASIATICA) leaf extract, CALENDULA OFFICINALIS (CALENDULA OFFICINALIS) flower extract.
3. The composition according to claim 1 wherein the emulsifier is at least one of cetyl alcohol and stearyl alcohol.
4. The composition according to claim 1, wherein the preservative is p-hydroxyacetophenone.
5. The composition according to claim 1 wherein the humectant is at least one of jojoba (SIMMONDSIA CHINENSIS) seed oil, glycerin, 1, 3-butanediol, 1, 2-hexanediol, 1, 2-pentanediol.
6. The inverse piezoelectric effect composition of claim 1 wherein the skin feel modifier is at least one of cyclopentademethicone, dimethicone.
7. A method of preparing the inverse piezoelectric effect composition of claim 1 comprising the steps of:
(1) Heating water to 80-85 ℃, adding the humectant, the skin feel modifier and the tocopherol acetate in the heating process, and dissolving to obtain a water phase;
(2) Heating lecithin, emulsifier and sodium hyaluronate to 70-90 ℃ to obtain an oil phase;
(3) Keeping the temperature at 80-85 ℃, stirring the homogenized water phase at 15000-20000 rpm, adding the oil phase, and continuously stirring and homogenizing for 5-10 min;
(4) Adjusting the stirring speed to 100-1000 rpm, cooling to 40-45 ℃, adding the plant extract, the nicotinamide, the caffeine and the preservative, and uniformly stirring to obtain the skin care composition;
(5) And introducing micro-current of 20-500 mu A into the skin care composition to obtain the composition with the inverse piezoelectric effect.
8. The composition with inverse piezoelectric effect according to claim 1, wherein the composition with inverse piezoelectric effect is obtained by applying micro-current of 20-500 μ Α to the skin care composition by using an eye massager;
the eye massager comprises a shell with an inner cavity, at least two massaging devices, a liquid storage device and a control structure;
an opening is formed in the middle of the shell, so that the liquid storage device is detachably embedded in the opening;
the massage device comprises metal balls, a heating piece, a first conductive module, a second conductive module and a conduit, wherein the metal balls are embedded in the middle of the heating piece, the heating piece is fixedly connected with the massage device, the conduit is arranged in the massage device, one end of the conduit is connected with the liquid storage device, and the other end of the conduit is abutted against the metal balls;
the casing inner chamber sets up control structure, control structure includes circuit mainboard, power and little current control module, circuit mainboard electric connection power and little current control module, little current control module is through first electrically conductive module electric connection metal ball, the piece that generates heat is through the electrically conductive module electric connection circuit mainboard of second.
9. Use of the composition for the inverse piezoelectric effect according to any one of claims 1 to 7 in a skin external preparation.
10. The use according to claim 9, wherein the skin external preparation is a cosmetic preparation, and the cosmetic preparation includes cream, pack, toner, emulsion, and gel.
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| CN114569537A (en) * | 2022-03-07 | 2022-06-03 | 开封市辰辰生物工程技术有限公司 | Skin care composition |
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|---|---|---|---|---|
| US20160089308A1 (en) * | 2014-09-29 | 2016-03-31 | Elc Management Llc | Targeted And Individualized Delivery Of Skincare Treatments With Micro-Current In A Mask Or Patch Form |
| CN109562028A (en) * | 2016-08-26 | 2019-04-02 | 科丝美诗株式会社 | Piezoelectricity cosmetic composition |
| CN212221055U (en) * | 2020-04-24 | 2020-12-25 | 佛山市辉鸿塑胶实业有限公司 | Warm-type rolling massage bottle cap |
| CN216676353U (en) * | 2021-10-15 | 2022-06-07 | 深圳市中和风科技开发有限公司 | Portable multifunctional eye massage instrument |
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