CN115624648A - 一种壳聚糖/介孔硅改性的医用止血纱布的制备方法及其产品 - Google Patents
一种壳聚糖/介孔硅改性的医用止血纱布的制备方法及其产品 Download PDFInfo
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Abstract
本发明涉及一种壳聚糖/介孔硅改性的医用止血纱布的制备方法及其产品,将模板剂P123与乙醇、乙酸混合,加入正硅酸四乙酯,在45℃混合搅拌4‑6小时,在500‑650℃煅烧5小时,球磨后过筛得到介孔二氧化硅粉末;将壳聚糖、醋酸纤维素溶于体积比1:1混合的丙酮、DMF溶液中,加入介孔二氧化硅,得到悬浮液;上述悬浮液作为纺丝液,通过静电纺丝技术涂覆与医用纱布表面,制备得到壳聚糖/介孔硅改性医用止血纱布。本发明结合有机成分壳聚糖对创面的保护作用和介孔二氧化硅的促凝血作用,提高纱布的止血效果。采用静电纺丝技术能将涂层与纱布紧密结合,同时有利于止血材料的均匀分布和固定,降低无机材料在创面的残留。
Description
技术领域
本发明涉及医疗器械的制备和加工的应用领域,具体是一种壳聚糖/介孔硅改性的医用止血纱布的制备方法及其产品,一种外科手术及创伤包扎中使用的医用止血纱布材料。
背景技术
创面出血难以有效止血是临床面临的一个难题,能否快速实现创面止血将直接影响伤者的感染率和死亡率。医用止血纱布是临床和生活中常用的一种创伤处理材料,起到接触创面、促进止血、隔绝外界接触的作用,因此,其安全性、有效性、可操作性、生物相容性等属性需要特别关注。在材料研究领域,通常使用能提高止血效果的有机、无机止血材料作为止血剂或敷料对纱布进行改性,但常用的粉末型止血剂,如壳聚糖止血粉、介孔硅等与纱布结合性不强,极易脱落,存在粉末残留、二次污染等安全隐患。静电纺丝技术能将涂层与纱布紧密结合,同时有利于止血材料的均匀分布和固定,降低无机材料在创面的残留。
基于以上研究背景,本发明提供了一种基于静电纺丝技术制备的壳聚糖/介孔硅改性的医用止血纱布的制备方法,提高止血纱布的安全性、有效性。
发明内容
本发明目的在于提供一种壳聚糖/介孔硅改性的医用止血纱布的制备方法,一种具备高安全性、有效性的医用止血纱布的制备方法。
本发明的再一目的在于:提供一种上述方法制备的壳聚糖/介孔硅改性的医用止血纱布产品。
本发明目的通过下述方案实现:一种壳聚糖/介孔硅改性的医用止血纱布的制备方法,其特征在于,包括以下步骤:
(1)将无水乙醇与冰醋酸、模板剂P123按体积比10:1:2混合均匀,加入10倍P123体积的正硅酸四乙酯,在45℃混合搅拌4-6小时,混合溶液在100℃烘箱中蒸干溶剂,置于500-650℃马弗炉中煅烧5小时,球磨后过150目筛网得到介孔二氧化硅粉末;
(2)将壳聚糖、醋酸纤维素溶于体积比1:1混合的丙酮、DMF溶液中,加入介孔二氧化硅,得到悬浮液;
(3)上述悬浮液作为纺丝液,通过静电纺丝技术涂覆与医用纱布表面,制备得到壳聚糖/介孔硅改性医用止血纱布。
步骤(1)所述的模板剂P123分子量为5800。
步骤(2)所述的壳聚糖、醋酸纤维素质量比为(70%-50%):(30-50%),按浓度10%(w/v)加入丙酮/DMF混合溶液。
步骤(2)所述的介孔二氧化硅按浓度0.1-1%(w/v)加入丙酮/DMF混合溶液。
步骤(3)所述的静电纺丝参数为纺丝电压15kv,接收距离10-20cm。
本发明提供一种壳聚糖/介孔硅改性的医用止血纱布,根据上述任一所述方法制备得到。
本发明的目的通过以下技术方案来实现:将模板剂P123与乙醇、乙酸混合,加入正硅酸四乙酯,在45℃混合搅拌4-6小时,在500-650℃煅烧5小时,球磨后过筛得到介孔二氧化硅粉末;将壳聚糖、醋酸纤维素溶于体积比1:1混合的丙酮、DMF溶液中,加入介孔二氧化硅,得到悬浮液;上述悬浮液作为纺丝液,通过静电纺丝技术涂覆与医用纱布表面,制备得到壳聚糖/介孔硅改性医用止血纱布。
本发明包括以下步骤:
1、将无水乙醇与冰醋酸、P123按体积比10:1:2混合均匀,加入10倍P123体积的正硅酸四乙酯,在45℃混合搅拌4-6小时。
2、混合溶液在100℃烘箱中蒸干溶剂,置于500-650℃马弗炉中煅烧5小时,球磨后过150目筛网得到介孔二氧化硅粉末。
3、将壳聚糖、醋酸纤维素按质量比(70%-50%):(30-50%)混合,加入体积比1:1的丙酮/DMF混合溶液中,配置成为溶质浓度为10%(w/v)的混合溶液,加入介孔二氧化硅粉末,使其浓度为0.1-1%(w/v),磁力搅拌下混合均匀得到悬浊液。
4、将上述悬浮液作为纺丝液,通过静电纺丝技术涂覆与医用纱布表面,纺丝电压为15kv,接收距离10-20cm,完毕后将所得纱布放入45℃真空烘箱中干燥过夜,制备得到壳聚糖/介孔硅改性医用止血纱布。
本发明结合有机成分壳聚糖对创面的保护作用和介孔二氧化硅的促凝血作用,提高纱布的止血效果。采用静电纺丝技术能将涂层与纱布紧密结合,同时有利于止血材料的均匀分布和固定,降低无机材料在创面的残留。
本发明的优点在于:
1,结合有机成分壳聚糖对创面的保护作用和介孔二氧化硅的促凝血作用,提高纱布的止血效果。
2,静电纺丝技术能将涂层与纱布紧密结合,同时有利于止血材料的均匀分布和固定,降低无机材料在创面的残留。
附图说明
附图1实施例3的 壳聚糖/介孔硅改性的医用止血纱布的SEM图。
具体实施方式
以下实施例以发明技术方案为前提进行实施,给出了详细的实施方式和具体的操作过程,但本发明的保护范围并不限于下述的实施例。
实施例1
一种壳聚糖/介孔硅改性的医用止血纱布,按以下步骤制备:
(1)将100mL乙醇、10mL冰醋酸、20mL P123混合均匀,加入200mL正硅酸四乙酯,在45℃混合搅拌6小时,混合溶液在100℃烘箱中蒸干溶剂,置于650℃马弗炉中煅烧5小时,球磨后过150目筛网得到介孔二氧化硅粉末;
(2)将2.5g壳聚糖、2.5g醋酸纤维素溶于50mL体积比1:1混合的丙酮/DMF溶液中,加入0.5g介孔二氧化硅,磁力搅拌混合均匀,得到悬浮液;
(3)上述悬浮液作为纺丝液转入注射器中,通过静电纺丝技术涂覆于医用纱布表面,纺丝电压为15kv,接收距离为15cm,完毕后将所得纱布放入45℃真空烘箱中干燥过夜,制备得到壳聚糖/介孔硅改性医用止血纱布。
实施例2
一种壳聚糖/介孔硅改性的医用止血纱布,与实施例1近似,按以下步骤制备:
(1)将100mL乙醇、10mL冰醋酸、20mL P123混合,加入200mL正硅酸四乙酯,在45℃混合搅拌6小时,混合溶液在100℃烘箱中蒸干溶剂,置于650℃马弗炉中煅烧5小时,球磨后过150目筛网得到介孔二氧化硅粉末;
(2)将3.5g壳聚糖、1.5g醋酸纤维素溶解于50mL 体积比1:1混合的丙酮/DMF溶液中,加入0.5g介孔二氧化硅粉末,磁力搅拌混合均匀,得到悬浮液;
(3)上述悬浮液作为纺丝液转入注射器中,通过静电纺丝技术涂覆与纱布表面,纺丝电压为15kv,接收距离为15cm,完毕后将所得纱布放入45℃真空烘箱中干燥过夜,制备得到壳聚糖/介孔硅改性医用止血纱布。
实施例3
一种壳聚糖/介孔硅改性的医用止血纱布,与实施例1近似,按以下步骤制备:
(1)将100mL乙醇、10mL冰醋酸、20mL P123混合,加入200mL正硅酸四乙酯,在45℃混合搅拌6小时,混合溶液在100℃烘箱中蒸干溶剂,置于650℃马弗炉中煅烧5小时,球磨后过150目筛网得到介孔二氧化硅粉末;
(2)将3.5g壳聚糖、1.5g醋酸纤维素溶解于50mL 体积比1:1混合的丙酮/DMF溶液中,加入0.1g介孔二氧化硅粉末,磁力搅拌混合均匀,得到悬浮液;
(3)上述悬浮液作为纺丝液转入注射器中,通过静电纺丝技术涂覆与纱布表面,纺丝电压为15kv,接收距离为15cm,完毕后将所得纱布放入45℃真空烘箱中干燥过夜,制备得到壳聚糖/介孔硅改性医用止血纱布。
SEM下观察结果如附图1所示。
Claims (6)
1.一种壳聚糖/介孔硅改性的医用止血纱布的制备方法,其特征在于,包括以下步骤:
(1)将无水乙醇与冰醋酸、模板剂P123按体积比10:1:2混合均匀,加入10倍P123体积的正硅酸四乙酯,在45℃混合搅拌4-6小时,混合溶液在100℃烘箱中蒸干溶剂,置于500-650℃马弗炉中煅烧5小时,球磨后过150目筛网得到介孔二氧化硅粉末;
(2)将壳聚糖、醋酸纤维素溶于体积比1:1混合的丙酮、DMF溶液中,加入介孔二氧化硅,得到悬浮液;
(3)上述悬浮液作为纺丝液,通过静电纺丝技术涂覆与医用纱布表面,制备得到壳聚糖/介孔硅改性医用止血纱布。
2.根据权利要求1所述一种壳聚糖/介孔硅改性的医用止血纱布的制备方法,其特征在于,步骤(1)所述的模板剂P123分子量为5800。
3.根据权利要求1所述一种壳聚糖/介孔硅改性的医用止血纱布的制备方法,其特征在于,步骤(2)所述的壳聚糖、醋酸纤维素质量比为(70%-50%):(30-50%),按浓度10%(w/v)加入丙酮/DMF混合溶液。
4.根据权利要求1所述一种壳聚糖/介孔硅改性的医用止血纱布的制备方法,其特征在于,步骤(2)所述的介孔二氧化硅按浓度0.1-1%(w/v)加入丙酮/DMF混合溶液。
5.根据权利要求1所述一种壳聚糖/介孔硅改性的医用止血纱布的制备方法,其特征在于,步骤(3)所述的静电纺丝参数为纺丝电压15kv,接收距离10-20cm。
6.一种壳聚糖/介孔硅改性的医用止血纱布,其特征在于根据权利要求1-5任一所述方法制备得到。
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