CN115624037A - Antibacterial antiviral antibiotic agent and preparation method thereof - Google Patents
Antibacterial antiviral antibiotic agent and preparation method thereof Download PDFInfo
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- CN115624037A CN115624037A CN202211062937.2A CN202211062937A CN115624037A CN 115624037 A CN115624037 A CN 115624037A CN 202211062937 A CN202211062937 A CN 202211062937A CN 115624037 A CN115624037 A CN 115624037A
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- hypochlorous acid
- sodium hypochlorite
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- antibacterial
- antiviral
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- 239000003242 anti bacterial agent Substances 0.000 title claims abstract description 26
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 26
- 230000000840 anti-viral effect Effects 0.000 title claims abstract description 20
- 229940088710 antibiotic agent Drugs 0.000 title claims abstract description 17
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 claims abstract description 41
- 239000005708 Sodium hypochlorite Substances 0.000 claims abstract description 36
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 claims abstract description 36
- 239000000243 solution Substances 0.000 claims abstract description 25
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000008213 purified water Substances 0.000 claims abstract description 7
- 239000011550 stock solution Substances 0.000 claims abstract description 7
- 238000003756 stirring Methods 0.000 claims description 21
- 239000000419 plant extract Substances 0.000 claims description 15
- 150000004283 biguanides Chemical class 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 10
- 239000003443 antiviral agent Substances 0.000 claims description 9
- 239000000284 extract Substances 0.000 claims description 9
- 239000011259 mixed solution Substances 0.000 claims description 9
- 239000002904 solvent Substances 0.000 claims description 8
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 claims description 5
- 229940123208 Biguanide Drugs 0.000 claims description 5
- 244000269722 Thea sinensis Species 0.000 claims description 4
- -1 alkylene biguanide hydrochloride Chemical compound 0.000 claims description 4
- FKPUYTAEIPNGRM-UHFFFAOYSA-N 1-(diaminomethylidene)guanidine;hydron;chloride Chemical compound [Cl-].N\C([NH3+])=N/C(N)=N FKPUYTAEIPNGRM-UHFFFAOYSA-N 0.000 claims description 3
- 229920001661 Chitosan Polymers 0.000 claims description 3
- 235000006484 Paeonia officinalis Nutrition 0.000 claims description 3
- 229920002413 Polyhexanide Polymers 0.000 claims description 3
- 229940069521 aloe extract Drugs 0.000 claims description 3
- 238000007865 diluting Methods 0.000 claims description 3
- 230000001105 regulatory effect Effects 0.000 claims description 3
- 235000017309 Hypericum perforatum Nutrition 0.000 claims description 2
- 244000141009 Hypericum perforatum Species 0.000 claims description 2
- 244000170916 Paeonia officinalis Species 0.000 claims 1
- 239000000645 desinfectant Substances 0.000 abstract description 20
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 18
- 238000002156 mixing Methods 0.000 abstract description 7
- 230000001954 sterilising effect Effects 0.000 abstract description 6
- 230000007062 hydrolysis Effects 0.000 abstract description 3
- 238000006460 hydrolysis reaction Methods 0.000 abstract description 3
- 210000000170 cell membrane Anatomy 0.000 description 10
- 244000005700 microbiome Species 0.000 description 9
- 210000004027 cell Anatomy 0.000 description 7
- 241000700605 Viruses Species 0.000 description 5
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 3
- 239000000460 chlorine Substances 0.000 description 3
- 229910052801 chlorine Inorganic materials 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000001257 hydrogen Chemical group 0.000 description 3
- 229910052739 hydrogen Chemical group 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 241000736199 Paeonia Species 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 239000000022 bacteriostatic agent Substances 0.000 description 2
- 230000019522 cellular metabolic process Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 210000000805 cytoplasm Anatomy 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 230000002147 killing effect Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000010907 mechanical stirring Methods 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 2
- 150000003904 phospholipids Chemical class 0.000 description 2
- 150000008442 polyphenolic compounds Chemical class 0.000 description 2
- 235000013824 polyphenols Nutrition 0.000 description 2
- 230000001902 propagating effect Effects 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 230000032895 transmembrane transport Effects 0.000 description 2
- 230000009385 viral infection Effects 0.000 description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- ZKQDCIXGCQPQNV-UHFFFAOYSA-N Calcium hypochlorite Chemical compound [Ca+2].Cl[O-].Cl[O-] ZKQDCIXGCQPQNV-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 241000711573 Coronaviridae Species 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 230000002155 anti-virotic effect Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000006479 redox reaction Methods 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/28—Myrtaceae [Myrtle family], e.g. teatree or clove
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/32—Ranunculaceae [Buttercup family], e.g. hepatica, hydrastis or goldenseal
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/40—Liliopsida [monocotyledons]
- A01N65/42—Aloeaceae [Aloe family] or Liliaceae [Lily family], e.g. aloe, veratrum, onion, garlic or chives
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
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- General Health & Medical Sciences (AREA)
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- Plant Pathology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
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- Agronomy & Crop Science (AREA)
- Microbiology (AREA)
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- Biotechnology (AREA)
- Pest Control & Pesticides (AREA)
- Chemical & Material Sciences (AREA)
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Abstract
The invention discloses a high-efficiency rapid antibacterial antiviral antibiotic agent and a preparation method thereof. The invention comprises the following components in parts by weight: 0.02-0.04 part of sodium hypochlorite stock solution, 10-30 parts of hypochlorous acid solution and the balance of purified water. Hypochlorous acid is unstable and is easily decomposed by light; the sodium hypochlorite mainly acts to form hypochlorous acid through hydrolysis, and the formed hypochlorous acid is used for sterilization again to indirectly play a role in disinfection; the invention adopts the mixing of the sodium hypochlorite and the hypochlorous acid with lower proportion, and the consumption of the hypochlorous acid in the disinfectant can be slowed down by mixing the sodium hypochlorite and the hypochlorous acid, so as to ensure the stability of the antibacterial effect; secondly, more than 95 percent of the water content is water, so that the skin is not damaged; compared with the existing disinfectant, the disinfectant has stable antibacterial and antiviral properties, and the effective period can reach 12 months.
Description
Technical Field
The invention relates to the field of antibiotics, in particular to an antibacterial antiviral antibiotic and a preparation method thereof.
Background
In the fields of daily life, medical treatment and public facilities and the like, harmful microorganisms such as bacteria, viruses and the like can be dispersed through air flow and combined with water, dust particles, object surfaces and the like, so that the health of people is threatened at any time. Therefore, it is necessary to impart antibacterial and antiviral properties to space and contact articles in daily life, medical care, public facilities, and the like. The existing common disinfectants are numerous, but the problems of large irritation, low disinfection efficiency, long disinfection time and the like exist.
Chlorine-containing disinfectants such as sodium hypochlorite, calcium hypochlorite and the like are a recognized chemical disinfectant which is most widely applied. Because it has the advantages of easy production, low price, convenient use, wide bactericidal spectrum and the like, it is the most commonly used bactericide in the disinfection medicine market at present, and plays a great role in daily life and major epidemic situations (such as SARS and novel coronavirus epidemic situations). However, the odor of the tea has great irritation, and under the condition of frequent use, people are bound to have great discomfort.
Patent CN 111567518A aims at providing a gelatinous sodium hypochlorite disinfectant and a preparation method and application thereof, the disinfectant uses sodium hypochlorite as an effective component, the sodium hypochlorite is stored in a sodium alginate hydrogel structure, the stability of the sodium hypochlorite is realized, and the effective and slow release of chlorine is realized by contacting with air during use, so that the indoor disinfection is effectively and durably realized. For the environment needing quick disinfection, the effective components of the gel-like sodium hypochlorite disinfectant are slowly released, and the quick propagation of bacteria and viruses can be caused.
Patent CN 112741106A is a hypochlorous acid disinfectant (powder) prepared by adding a drier to chlorine powder, stirring, sequentially adding sodium dihydrogen phosphate, citric acid or pH acidic components or raw materials, adding excipient while stirring, and stirring for about 20-30 minutes until uniform. The method has the disadvantages of complicated preparation process, various raw materials, inconvenient use of the prepared powder and use defects.
Disclosure of Invention
The technical problems to be solved by the invention are as follows: the invention aims to solve the defects in the prior art and provides a high-efficiency rapid antibacterial antiviral disinfectant which can effectively promote the sterilization and disinfection of hypochlorous acid, has the function of inhibiting the volatilization of the hypochlorous acid, and has stable performance and long validity period, and a preparation method thereof.
The technical scheme of the invention is as follows: the invention provides a high-efficiency rapid antibacterial antiviral antibiotic agent, which comprises the following components in parts by weight: 0.02-0.04 part of sodium hypochlorite stock solution, 10-30 parts of hypochlorous acid solution and the balance of purified water.
Further, 0.01-0.03 part of biguanide salt solvent is also included.
Further, the biguanide salt solvent is one or more of polyhexamethylene biguanide hydrochloride, chitosan biguanide hydrochloride and alkylene biguanide hydrochloride.
Further comprises 0.1-0.5 part of PH regulator, 0.02-0.05 part of plant extract and 0.001-0.003 part of essence.
Further, the plant extract is one or a combination of more of peony root and bark extract, aloe extract, tea extract and hypericum perforatum extract.
The invention also discloses a preparation method of the efficient and rapid antibacterial, antiviral and antibiotic agent, which comprises the following steps:
s1, diluting a sodium hypochlorite solution; adding purified water into a beaker, dissolving sodium hypochlorite stock solution in water, and uniformly stirring for 20-30min by magnetic force;
s2, preparing a mixed solution of sodium hypochlorite and hypochlorous acid; adding hypochlorous acid solution into the diluted sodium hypochlorite solution, and stirring for 30-40min.
Further, the method also comprises a step S3 of adding a biguanide solution into the mixed solution of the sodium hypochlorite and the hypochlorous acid, and stirring for 10-20min.
Further, the method also comprises the following steps,
s4, adding the plant extract into the solution, and stirring for 5-10min;
s5, slowly adding a pH regulator into the solution obtained in the step S4 while stirring, and regulating the PH value to 3.0-6.5;
s6, adding an essence solution into the mixed solution obtained in the step S5, and stirring for 10-20min.
Has the advantages that:
compared with the prior art, the invention has the beneficial effects that:
1. hypochlorous acid is instable, and is easily decomposed by light; the sodium hypochlorite mainly plays a role in forming hypochlorous acid through hydrolysis, and the formed hypochlorous acid is used for sterilization again to indirectly play a role in disinfection; the invention adopts the mixing of the sodium hypochlorite and the hypochlorous acid with lower proportion, and the consumption of the hypochlorous acid in the disinfectant can be slowed down by mixing the sodium hypochlorite and the hypochlorous acid, so as to ensure the stability of the antibacterial effect; secondly, more than 95 percent of the water content is water, so that the skin is not damaged; compared with the existing disinfectant, the disinfectant has stable antibacterial and antiviral properties, and the effective period can reach 12 months.
2. The antibiotic agent is added with a low-concentration biguanide solvent, and the biguanide salt is a polycationic compound and can be adsorbed on the surface of negatively charged microorganisms to prevent the microorganisms from splitting and propagating; simultaneously, the biguanide salt adsorbed on the surface of the microorganism acts on phospholipid bilayers in cytoplasm through transmembrane transport and is combined with negatively charged phosphate groups, so that the selective permeability of cell membranes is changed, the cell metabolism is destroyed, the microorganism is killed, and the synergistic effect of sodium hypochlorite and hypochlorous acid mixed liquor can realize more effective sterilization and disinfection.
3. The invention adds plant extract to assist sterilization and virus resistance, and the bacteriostatic substance in the natural plant extract can destroy the cell membrane of bacterial cells, destroy the cell morphology, and make the substance in the cells flow out, finally leading to the complete rupture of the cells. For example, hydroxyl and hydrogen bonds contained in the polyphenols can be embedded into a hydrophobic structure of a cell membrane, so that the fluidity of the cell membrane is reduced, the material exchange of the cell membrane of a virus host is hindered, and the virus infection is inhibited; secondly, the plant extract is green and environment-friendly and harmless to human bodies; the preparation method adopts simple mechanical stirring, the mixing method is simple and easy to operate, and the disinfectant can be used for killing personal, household articles and public facilities.
Detailed Description
In order to enhance the understanding of the present invention, the present invention will be further described in detail with reference to the following examples, which are only used for explaining the present invention and are not to be construed as limiting the scope of the present invention.
Firstly, the invention discloses a high-efficiency and rapid antibacterial antiviral antibiotic agent, which comprises the following components in parts by weight: 0.02-0.04 part of sodium hypochlorite stock solution, 10-30 parts of hypochlorous acid solution, 0.01-0.03 part of biguanide salt solvent, 0.1-0.5 part of pH regulator, 0.02-0.05 part of plant extract, 0.001-0.003 part of essence and the balance of purified water.
Wherein the biguanide salt solvent is one or more of polyhexamethylene biguanide hydrochloride, chitosan biguanide hydrochloride and alkylene biguanide hydrochloride;
the pH regulator is one or the combination of more of hydrochloric acid and phosphoric acid with the concentration of 0.1 mol/L;
the plant extract is one or more of peony root and bark extract, aloe extract, tea extract and herba Hyperici perforati extract.
The invention also comprises a preparation method of the efficient and rapid antibacterial, antiviral and antibiotic agent, which comprises the following specific steps:
s1, diluting a sodium hypochlorite solution; adding purified water into a beaker, dissolving sodium hypochlorite stock solution in water, and uniformly stirring for 20-30min by magnetic force;
s2, preparing a mixed solution of sodium hypochlorite and hypochlorous acid; adding hypochlorous acid solution into the diluted sodium hypochlorite solution, and stirring for 30-40min;
s3, adding a biguanide solution into a mixed solution of sodium hypochlorite and hypochlorous acid, and stirring for 10-20min;
s4, adding the plant extract into the solution, and stirring for 5-10min;
s5, slowly adding a pH regulator into the solution obtained in the step S4 while stirring, and regulating the PH value to be 3.0-6.5.
S6, adding the essence solution into the mixed solution in the step S5, and stirring for 10-20min.
The disinfectant has the characteristics of effectively promoting the hypochlorous acid to sterilize and disinfect, inhibiting the volatilization of the hypochlorous acid, stabilizing the performance of the disinfectant and prolonging the effective period; hypochlorous acid slowly undergoes self-redox reaction and is decomposed, and each hypochlorous acid molecule absorbs electrons during decomposition, so that the aim of sterilization is fulfilled, and hydrogen ions, chloride ions and oxygen are dissociated. The equation is as follows:
2HOCl→2H + +2Cl - +O 2 ↑
hypochlorous acid is unstable, so that the hypochlorous acid is easily decomposed by light; the sodium hypochlorite mainly acts to form hypochlorous acid through hydrolysis, and the formed hypochlorous acid is used for sterilization again to indirectly play a role in disinfection.
Therefore, the invention adopts the lower proportion of the sodium hypochlorite to be mixed with the hypochlorous acid, and the consumption of the hypochlorous acid in the disinfectant can be slowed down by mixing the sodium hypochlorite and the hypochlorous acid, so as to ensure the stability of the antibacterial effect; secondly, the invention contains more than 95 percent of water, which does not harm the skin; compared with the existing disinfectant, the disinfectant has stable antibacterial and antiviral properties, and the effective period can reach 12 months.
Secondly, a low-concentration biguanide solvent is added into the antibiotic agent, and the biguanide salt is a polycationic compound and can be adsorbed on the surface of the negatively charged microorganism to prevent the microorganism from splitting and propagating; simultaneously, the biguanide salt adsorbed on the surface of the microorganism acts on phospholipid bilayers in cytoplasm through transmembrane transport and is combined with negatively charged phosphate groups, so that the selective permeability of cell membranes is changed, the cell metabolism is destroyed, the microorganism is killed, and the synergistic effect of sodium hypochlorite and hypochlorous acid mixed liquid can be realized to realize more effective sterilization and disinfection.
Finally, the plant extract is added to assist sterilization and antivirus, and bacteriostatic substances in the natural plant extract can destroy cell membranes of bacterial cells and cell morphology, so that intracellular substances flow out, and finally the cells are completely broken. For example, hydroxyl and hydrogen bonds contained in the polyphenols can be embedded into a hydrophobic structure of a cell membrane, so that the fluidity of the cell membrane is reduced, the material exchange of the cell membrane of a virus host is hindered, and the virus infection is inhibited; secondly, the plant extract is green and environment-friendly and harmless to human bodies; the preparation method adopts simple mechanical stirring, the mixing method is simple and easy to operate, and the sterilization and disinfection agent can be used for killing personal, household articles and public facilities.
The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (8)
1. An antibacterial, antiviral and antibiotic agent, characterized in that: comprises the following components in parts by weight: 0.02-0.04 part of sodium hypochlorite stock solution, 10-30 parts of hypochlorous acid solution and the balance of purified water.
2. The antibacterial, antiviral and antibiotic agent according to claim 1, wherein: also comprises 0.01-0.03 part of biguanide salt solvent.
3. The antibacterial, antiviral and antibiotic agent according to claim 2, wherein: the biguanide salt solvent is one or a combination of polyhexamethylene biguanide hydrochloride, chitosan biguanide hydrochloride and alkylene biguanide hydrochloride.
4. The antibacterial and antiviral agent according to any one of claims 1 to 3, wherein: also comprises pH regulator 0.1-0.5 parts, plant extract 0.02-0.05 parts and essence 0.001-0.003 parts.
5. The antibacterial, antiviral and antibiotic agent according to claim 4, wherein: the plant extract is one or more of peony root and bark extract, aloe extract, tea extract and hypericum perforatum extract.
6. A preparation method of a high-efficiency and rapid antibacterial, antiviral and antibiotic agent is characterized by comprising the following steps: the method comprises the following steps:
s1, diluting a sodium hypochlorite solution; adding purified water into a beaker, dissolving sodium hypochlorite stock solution in water, and uniformly stirring for 20-30min by magnetic force;
s2, preparing a mixed solution of sodium hypochlorite and hypochlorous acid; adding hypochlorous acid solution into the diluted sodium hypochlorite solution, and stirring for 30-40min.
7. The method for preparing the highly effective and rapid antibacterial, antiviral and antibiotic agent according to claim 6, wherein the method comprises the following steps: and S3, adding a biguanide solution into the mixed solution of the sodium hypochlorite and the hypochlorous acid, and stirring for 10-20min.
8. The method for preparing the highly effective rapid antibacterial antiviral antibiotic agent according to claim 6 or 7, wherein: the method also comprises the following steps of,
s4, adding the plant extract into the solution, and stirring for 5-10min;
s5, slowly adding a pH regulator into the solution obtained in the step S4, stirring while adding, and regulating the PH value to be 3.0-6.5.
S6, adding an essence solution into the mixed solution obtained in the step S5, and stirring for 10-20min.
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| CN113645955A (en) * | 2019-02-28 | 2021-11-12 | 临床健康科技有限公司 | Stable hypochlorous acid solution and its medical and cosmetic use |
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| CN113645955A (en) * | 2019-02-28 | 2021-11-12 | 临床健康科技有限公司 | Stable hypochlorous acid solution and its medical and cosmetic use |
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