CN117530291A - Activation-free slow-release air disinfectant and preparation method thereof - Google Patents
Activation-free slow-release air disinfectant and preparation method thereof Download PDFInfo
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- CN117530291A CN117530291A CN202311504118.3A CN202311504118A CN117530291A CN 117530291 A CN117530291 A CN 117530291A CN 202311504118 A CN202311504118 A CN 202311504118A CN 117530291 A CN117530291 A CN 117530291A
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- Prior art keywords
- activation
- carrier
- chlorite
- release air
- air disinfectant
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- 239000000645 desinfectant Substances 0.000 title claims abstract description 53
- 238000002360 preparation method Methods 0.000 title abstract description 10
- 239000002253 acid Substances 0.000 claims abstract description 22
- 229910001919 chlorite Inorganic materials 0.000 claims abstract description 21
- 229910052619 chlorite group Inorganic materials 0.000 claims abstract description 21
- QBWCMBCROVPCKQ-UHFFFAOYSA-N chlorous acid Chemical compound OCl=O QBWCMBCROVPCKQ-UHFFFAOYSA-N 0.000 claims abstract description 20
- 150000003839 salts Chemical class 0.000 claims abstract description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 3
- 235000002639 sodium chloride Nutrition 0.000 claims description 21
- 239000000203 mixture Substances 0.000 claims description 17
- 238000002156 mixing Methods 0.000 claims description 14
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 11
- 239000000796 flavoring agent Substances 0.000 claims description 9
- 235000013355 food flavoring agent Nutrition 0.000 claims description 9
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims description 6
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 239000002245 particle Substances 0.000 claims description 6
- -1 hydrogen ions Chemical class 0.000 claims description 5
- UKLNMMHNWFDKNT-UHFFFAOYSA-M sodium chlorite Chemical compound [Na+].[O-]Cl=O UKLNMMHNWFDKNT-UHFFFAOYSA-M 0.000 claims description 5
- 229960002218 sodium chlorite Drugs 0.000 claims description 5
- 229940103272 aluminum potassium sulfate Drugs 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 230000007062 hydrolysis Effects 0.000 claims description 4
- 238000006460 hydrolysis reaction Methods 0.000 claims description 4
- GRLPQNLYRHEGIJ-UHFFFAOYSA-J potassium aluminium sulfate Chemical compound [Al+3].[K+].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O GRLPQNLYRHEGIJ-UHFFFAOYSA-J 0.000 claims description 4
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims description 4
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 3
- 239000000440 bentonite Substances 0.000 claims description 3
- 229910000278 bentonite Inorganic materials 0.000 claims description 3
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 3
- 239000001110 calcium chloride Substances 0.000 claims description 3
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 3
- 239000001257 hydrogen Substances 0.000 claims description 3
- 229910052739 hydrogen Inorganic materials 0.000 claims description 3
- 229910001629 magnesium chloride Inorganic materials 0.000 claims description 3
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims description 3
- 235000019341 magnesium sulphate Nutrition 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- VISKNDGJUCDNMS-UHFFFAOYSA-M potassium;chlorite Chemical compound [K+].[O-]Cl=O VISKNDGJUCDNMS-UHFFFAOYSA-M 0.000 claims description 3
- 239000011780 sodium chloride Substances 0.000 claims description 3
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 3
- 229960001763 zinc sulfate Drugs 0.000 claims description 3
- 229910000368 zinc sulfate Inorganic materials 0.000 claims description 3
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 2
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims description 2
- HSEYYGFJBLWFGD-UHFFFAOYSA-N 4-methylsulfanyl-2-[(2-methylsulfanylpyridine-3-carbonyl)amino]butanoic acid Chemical compound CSCCC(C(O)=O)NC(=O)C1=CC=CN=C1SC HSEYYGFJBLWFGD-UHFFFAOYSA-N 0.000 claims description 2
- 241001529821 Agastache Species 0.000 claims description 2
- 239000005995 Aluminium silicate Substances 0.000 claims description 2
- 241000196324 Embryophyta Species 0.000 claims description 2
- 241000628997 Flos Species 0.000 claims description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 2
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims description 2
- 235000012211 aluminium silicate Nutrition 0.000 claims description 2
- YUUVAZCKXDQEIS-UHFFFAOYSA-N azanium;chlorite Chemical compound [NH4+].[O-]Cl=O YUUVAZCKXDQEIS-UHFFFAOYSA-N 0.000 claims description 2
- 235000012216 bentonite Nutrition 0.000 claims description 2
- 239000001506 calcium phosphate Substances 0.000 claims description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 2
- 235000011010 calcium phosphates Nutrition 0.000 claims description 2
- QXIKMJLSPJFYOI-UHFFFAOYSA-L calcium;dichlorite Chemical compound [Ca+2].[O-]Cl=O.[O-]Cl=O QXIKMJLSPJFYOI-UHFFFAOYSA-L 0.000 claims description 2
- 229940025250 camphora Drugs 0.000 claims description 2
- 239000010238 camphora Substances 0.000 claims description 2
- 239000000284 extract Substances 0.000 claims description 2
- 239000003205 fragrance Substances 0.000 claims description 2
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims description 2
- GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 claims description 2
- 239000004137 magnesium phosphate Substances 0.000 claims description 2
- 229910000157 magnesium phosphate Inorganic materials 0.000 claims description 2
- 229960002261 magnesium phosphate Drugs 0.000 claims description 2
- 235000010994 magnesium phosphates Nutrition 0.000 claims description 2
- NWAPVVCSZCCZCU-UHFFFAOYSA-L magnesium;dichlorite Chemical compound [Mg+2].[O-]Cl=O.[O-]Cl=O NWAPVVCSZCCZCU-UHFFFAOYSA-L 0.000 claims description 2
- GJPYYNMJTJNYTO-UHFFFAOYSA-J sodium aluminium sulfate Chemical compound [Na+].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O GJPYYNMJTJNYTO-UHFFFAOYSA-J 0.000 claims description 2
- 229910052938 sodium sulfate Inorganic materials 0.000 claims description 2
- 235000011152 sodium sulphate Nutrition 0.000 claims description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 2
- 239000011592 zinc chloride Substances 0.000 claims description 2
- 235000005074 zinc chloride Nutrition 0.000 claims description 2
- LRXTYHSAJDENHV-UHFFFAOYSA-H zinc phosphate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O LRXTYHSAJDENHV-UHFFFAOYSA-H 0.000 claims description 2
- 229910000165 zinc phosphate Inorganic materials 0.000 claims description 2
- OSVXSBDYLRYLIG-UHFFFAOYSA-N dioxidochlorine(.) Chemical compound O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 abstract description 80
- 239000004155 Chlorine dioxide Substances 0.000 abstract description 40
- 235000019398 chlorine dioxide Nutrition 0.000 abstract description 40
- 230000000694 effects Effects 0.000 abstract description 23
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 15
- 241000700605 Viruses Species 0.000 abstract description 8
- 241000894006 Bacteria Species 0.000 abstract description 6
- 239000000463 material Substances 0.000 abstract description 5
- 239000000126 substance Substances 0.000 abstract description 5
- 230000000415 inactivating effect Effects 0.000 abstract description 3
- 230000009982 effect on human Effects 0.000 abstract description 2
- 231100000614 poison Toxicity 0.000 abstract description 2
- 239000003440 toxic substance Substances 0.000 abstract description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 21
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- 230000000052 comparative effect Effects 0.000 description 7
- 230000001954 sterilising effect Effects 0.000 description 6
- 230000002147 killing effect Effects 0.000 description 5
- 239000000741 silica gel Substances 0.000 description 5
- 229910002027 silica gel Inorganic materials 0.000 description 5
- 241000711573 Coronaviridae Species 0.000 description 4
- 238000013268 sustained release Methods 0.000 description 4
- 239000012730 sustained-release form Substances 0.000 description 4
- 241000282414 Homo sapiens Species 0.000 description 3
- 241000191967 Staphylococcus aureus Species 0.000 description 3
- 244000052616 bacterial pathogen Species 0.000 description 3
- 239000000969 carrier Substances 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000003958 fumigation Methods 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 239000002304 perfume Substances 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 239000012286 potassium permanganate Substances 0.000 description 2
- 239000012629 purifying agent Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 241000723346 Cinnamomum camphora Species 0.000 description 1
- 241000709661 Enterovirus Species 0.000 description 1
- 241000588722 Escherichia Species 0.000 description 1
- 241000711467 Human coronavirus 229E Species 0.000 description 1
- 206010028400 Mutagenic effect Diseases 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 108020000999 Viral RNA Proteins 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 235000011132 calcium sulphate Nutrition 0.000 description 1
- 238000009924 canning Methods 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 239000011133 lead Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 231100000243 mutagenic effect Toxicity 0.000 description 1
- 230000003505 mutagenic effect Effects 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 231100000590 oncogenic Toxicity 0.000 description 1
- 230000002246 oncogenic effect Effects 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 210000004777 protein coat Anatomy 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 231100000378 teratogenic Toxicity 0.000 description 1
- 230000003390 teratogenic effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/06—Aluminium; Calcium; Magnesium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/16—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/26—Phosphorus; Compounds thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Chemical & Material Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The application provides an activation-free slow-release air disinfectant and a preparation method thereof, and relates to the technical field of disinfection materials. The activation-free slow-release air disinfectant comprises the following components in percentage by weight: 1-30% of chlorite, 5-98% of carrier and the balance of strong acid salt in weak base, and the specific components and contents of all the components are controlled, so that the obtained activation-free slow-release air disinfectant can be activated by water or sunlight in the air, the release time and speed of chlorine dioxide can be controlled, the slow-release effect is achieved, the efficacy of stably inactivating viruses and bacteria is achieved, the influence of temperature is small, three-effect substances and other toxic substances are not generated, and the activation-free slow-release air disinfectant has no harm effect on human bodies.
Description
Technical Field
The invention relates to the technical field of disinfection materials, in particular to an activation-free slow-release air disinfectant and a preparation method thereof.
Background
Conventionally, fumigation and other methods are used for air disinfection, for example, a fumigation method for formaldehyde and a disinfection device thereof are disclosed in Chinese patent CN104800872A, which can well control the contact time of formaldehyde and potassium permanganate, lead the formaldehyde to react completely, ensure that formaldehyde liquid is not remained so as to achieve the effect of fumigation and disinfection on a closed room; reacting formaldehyde with potassium permanganate after an operator leaves a disinfection room; the whole disinfection process avoids the generation of open fire and ensures the safety of operators; however, the formaldehyde is disinfected, so that on the one hand, a heavy smell is left, and after entering the formaldehyde, people easily irritate tissues such as mucous membranes in a short time, so that discomfort is caused to the human body, and on the other hand, the safety of the formaldehyde is also very questioned.
Chlorine dioxide (ClO) 2 ) Is a novel, internationally recognized, safe and nontoxic green disinfectant. Related studies have shown that ClO 2 At concentrations of tens of ppm, the virus is completely killed, as it can destroy proteins on the surface of the virus, rendering it unable to bind to host cells. Simultaneous ClO 2 Has no teratogenic, oncogenic and mutagenic effects, and is a ClO 2 When the concentration is less than 500mg/L, the effect on human body is small, so ClO 2 Widely applied to the disinfection of foods, equipment, environment and the like.
As disclosed in Chinese patent CN1887356A, a slow-release chlorine dioxide air disinfectant takes silica gel as a solid carrier of chlorine dioxide solution, and comprises the following components in percentage by weight: 1-3 parts of an activation-free or stable chlorine dioxide solution and 3 parts of silica gel; or 1-3 parts of stable chlorine dioxide solution, 3 parts of silica gel and 0.005-0.1 part of activator. The slow release effect is good, the volatilization speed of the chlorine dioxide solution in the silica gel is uniform and continuous, the concentration of the chlorine dioxide gas in the air is proper, and the slow release period is long. The citric acid has good activating effect, long acting time, no pungent peculiar smell and good effect of sterilizing air. The product is mainly used for indoor air disinfection, can be recycled after being used, and can be prepared into slow-release air disinfectant by adding solutions such as chlorine dioxide and the like again after the silica gel is treated.
For example, chinese patent CN105123748A discloses an aromatic immobilized granular activation-free chlorine dioxide air purifying agent, which belongs to the field of environmental purification, and the formula of the agent is as follows: curing agent, chlorine dioxide generator, perfume, colorant, slow release agent, filler, etc., the preparation steps are: the purifying agent can effectively kill harmful substances such as bacteria, viruses, chemical toxins, residual pesticides and the like, is convenient to use, simple to operate, obvious in effect, long in acting, safe and long in shelf life, and has wide application prospects in the fields of household environments, medical care, sanitary epidemic prevention and the like. However, the existing chlorine dioxide disinfectant has poor slow release effect, so that it is necessary to provide an activation-free slow release air disinfectant with long-acting slow release effect and stable effect of inactivating viruses and bacteria.
Disclosure of Invention
Based on the problems in the prior art, the application aims to provide an activation-free long-acting slow-release chlorine dioxide air disinfectant and a preparation method thereof.
In order to achieve the above purpose, the present application adopts the following technical scheme:
in one aspect, the application provides an activation-free slow-release air disinfectant, comprising, by weight: 1-30% of chlorite, 5-98% of carrier and the balance of strong acid salt in weak base.
Wherein:
the chlorite is one or more selected from sodium chlorite, magnesium chlorite, potassium chlorite, ammonium chlorite and calcium chlorite; the particle size of the chlorite is smaller than 40 meshes.
The strong acid salt in the weak base is one or more selected from calcium chloride, zinc chloride, magnesium chloride, aluminum potassium sulfate, aluminum sodium sulfate, aluminum ammonium sulfate, zinc sulfate, magnesium sulfate, calcium phosphate, magnesium phosphate, zinc phosphate and aluminum phosphate; the particle size of the strong acid salt in the weak base is smaller than 40 meshes.
As some preferred embodiments, the ratio of the hydrogen ions released by the complete hydrolysis of the strong acid salt in the weak base to the chlorite ions released by the complete hydrolysis of the chlorite salt is 4:5.
The carrier comprises a carrier A and a carrier B;
the carrier A is one or more selected from diatomite, bentonite, sodium sulfate and sea salt;
the carrier B is one or more selected from kaolin, diatomite and volcanic ash;
the mass ratio of the carrier A to the carrier B is 0.7-1.3:1.
the particle size of the carrier A and the carrier B is less than or equal to 60 meshes, and the moisture content of the carrier A and the carrier B is less than or equal to 5%.
As some preferred embodiments, the activation-free slow release air sanitizer further comprises a fragrance; the flavoring agent is one or more selected from Camphora, borneolum Syntheticum, herba Menthae, fructus Citri Limoniae, herba Agastaches, lignum Cinnamomi Camphorae, flos Magnoliae, pericarpium Citri Tangerinae, herba Schizonepetae and their extracts; the grain diameter of the flavoring agent is less than or equal to 60 meshes when the flavoring agent is plant tissue, and the water content is less than or equal to 5%.
On the other hand, the application also provides a preparation method of the activation-free slow-release air disinfectant, which comprises the following steps:
(1) Mixing chlorite and carrier A to obtain mixture 1;
(2) Fully mixing strong acid salt in weak base with a carrier B and a flavoring agent to obtain a mixture 2;
(3) And fully and uniformly mixing the mixture 1 and the mixture 2 to obtain the activation-free slow-release air disinfectant.
In step 1), carrier A has a diluting effect with the aim of reducing the direct contact of chlorite with the strong acid of the weak acid. To achieve this effect, the chlorite content of the mixture 1 (carrier a and chlorite) should be 35% or more.
The mixing in the step (3) refers to mixing in an environment where the air humidity is lower than 50% and direct sunlight is avoided.
The activation-free long-acting slow-release chlorine dioxide air disinfectant disclosed by the invention can be applied to air disinfection in working scenes under epidemic situations, and can also be applied to disinfection of office tables, dining tables and surrounding air in places of activities; and can also be used for sterilizing dead corners in production workshops, especially in environments where conventional sterilization is difficult to reach.
Pathogenic microorganisms which do not have the effect of the activation-free long-acting slow-release chlorine dioxide air disinfectant include but are not limited to viruses of the genus coronavirus, enteroviruses, bacteria of the genus escherichia, bacteria of the genus staphylococcus and the like.
Compared with the prior art, the technical scheme provided by the invention has at least the following beneficial effects:
(1) The activation-free long-acting slow-release chlorine dioxide air disinfectant disclosed by the invention is activated by the moisture or sunlight in the air, so that the duration and the speed of releasing chlorine dioxide are controlled, and the slow-release effect is achieved;
(2) The main component of the disinfectant disclosed by the invention is chlorine dioxide, has the efficacy of stably inactivating viruses and bacteria, is little affected by temperature, does not generate three-causing substances and other toxic substances, and has no harm to human bodies;
(3) The chlorine dioxide can inactivate more than 99% of pathogenic bacteria such as coronavirus (Hcov-229E) and Escherichia coli, and has no toxic effect on cells.
Drawings
FIG. 1 is a bar graph of chlorine dioxide release rates for disinfectants prepared in various embodiments;
FIG. 2 is a graph showing the effect of strong acid salts in various weak bases on the amount of chlorine dioxide released.
Detailed Description
The following examples are illustrative of the invention and are not intended to limit the scope of the invention. Unless otherwise indicated, the technical means used in the examples are conventional means well known to those skilled in the art, and all raw materials used are commercially available.
Basic embodiment preparation method of activation-free long-acting slow-release chlorine dioxide air disinfectant
The method comprises the following steps:
(1) According to the specific packaging and canning mode, the materials are properly crushed, and the crushing needs to be carried out independently, so that the mixing and crushing of chlorite and organic materials are avoided;
(2) Mixing chlorite and carrier A to obtain mixture 1;
(3) Fully mixing strong acid salt in weak base with a carrier B and a flavoring agent to obtain a mixture 2;
(4) And (3) fully and uniformly mixing the mixture 1 and the mixture 2 in an environment with the air humidity lower than 50% and avoiding direct sunlight, so as to obtain the activation-free long-acting slow-release chlorine dioxide air disinfectant, wherein the air disinfectant needs to be sealed in a water-proof way and stored in a dark place.
Examples 1-13 an activation-free long-acting sustained-release chlorine dioxide air disinfectant
The contents of the materials are shown in Table 1, and the preparation method is the same as that of the basic example.
Table 1 content of each material (%), weight calculated on pure substance of identified component, in the activation-free long-acting slow-release chlorine dioxide air disinfectant
Comparative example 1
According to the prior art, the preparation method of the slow-release chlorine dioxide air disinfectant comprises the following steps: sodium chlorite 0.05 g, citric acid 0.1 g, aluminum potassium sulfate 0.15 g, perfume 0.3 g, total 0.5 g, according to the above composition and proportion, the slow release chlorine dioxide air disinfectant is obtained.
Comparative example 2
In order to compare the slow release effect of the chlorine dioxide disinfectant disclosed by the invention, a conventional chlorine dioxide air disinfectant is prepared: sodium chlorite 0.05 g, citric acid 0.1 g, perfume 0.3 g, total 0.45 g, according to above composition and proportion, get the conventional chlorine dioxide air disinfectant.
Effect verification
1、ClO 2 Is effective in releasing
To evaluate ClO 2 The chlorine dioxide air disinfectants prepared in examples 1 to 13, comparative example 1 and comparative example 2 were placed in air, the weight of the disinfectants was measured every 1 hour, and the average release rate was calculated, and the results are shown in fig. 1 and table 2.
TABLE 2 ClO of different compositions 2 Is effective in releasing
| Composition and method for producing the same | Average release rate (g/h) | Duration (h) |
| Example 4 | 0.001 | 50 |
| Comparative example 1 | 0.005 | 10 |
| Comparative example 2 | 0.15 | 0.33 |
As can be seen from FIG. 1, the disinfectant prepared by the above example releases ClO 2 The rate of (2) is between 0.001 and 0.038g/h, indicating ClO 2 Is slowly released, improves ClO 2 The utilization rate of the purified air is further improved, and the sterilization and disinfection capacity is further improved.
Table 2 shows that the disinfectant prepared in example 4 slowly releases ClO 2 The duration is as long as 50 hours, and the slow-release disinfectant prepared according to the prior art can only release ClO for 10 hours continuously 2 This is because in example 4, the strong acid salt of weak base is used to slowly hydrolyze and release hydrogen ions, which then react with chlorite to generate chlorine dioxide gas, and the carrier is used to avoid direct contact between the strong acid salt of weak base and chlorite, thereby prolonging ClO 2 Is not required, and the release time of the same. In contrast, for the disinfectant prepared in comparative example 2, sodium chlorite reacted rapidly with strong acid to release ClO in less than half an hour 2 There is no slow release effect.
2、ClO 2 Is effective in killing of (a)
In order to evaluate the killing effect of the activation-free long-acting slow-release chlorine dioxide air disinfectant on viruses and pathogenic bacteria, human crown disease (HCoV-229E), escherichia coli and staphylococcus aureus are selected, and the chlorine dioxide disinfectant prepared in examples 1-9 is filled into a gas permeable bag for experiment, and the results are shown in tables 3 and 4.
TABLE 3 ClO 2 Sterilizing effect of disinfectant on coronavirus
TABLE 4 ClO 2 Killing effect of disinfectant on colibacillus and staphylococcus aureus
According to the result of the experiment,examples 1-9 have good killing effect on coronaviruses, colibacillosis and staphylococcus aureus, and the killing rate is up to more than 99%. ClO (ClO) 2 The principle of viral inactivation is to destroy the viral RNA and protein coat, thereby losing its ability to infect the host cell. ClO (ClO) 2 The aim of sterilization can be achieved by increasing the permeability of the bacterial cell wall and increasing the osmotic pressure difference inside and outside the bacterial cell membrane. In conclusion, the activation-free long-acting slow-release chlorine dioxide air disinfectant prepared by the experiment can kill pathogens and pathogenic bacteria in the air.
3. Comparing the slow release effect of strong acid salt in different weak base
The effect of strong acid salts in various weak bases of 2.3% of calcium chloride, magnesium chloride, zinc sulfate, aluminum potassium sulfate, magnesium sulfate and calcium sulfate on slow release of chlorine dioxide was compared under the conditions of 5% of potassium chlorite, 40.4% of sea salt, 2.3% of camphor tree oil and 50% of diatomite, and the result is shown in figure 2.
The results in fig. 2 show that the release rate of zinc salt is the fastest, followed by aluminum and calcium salts, and the release rate of magnesium salt is the slowest.
4. Comparing the slow release effect of different carriers
Under the same conditions, the sustained release effects of different carriers and ratios on chlorine dioxide are compared, and the specific results are shown in the following table 5.
TABLE 5 sustained release effects of different Mass ratios of carriers
As shown in Table 5, bentonite is used as a carrier A, diatomite is used as a carrier B, and when the mass ratio is 0.7,1,1.3, the release rate of chlorine dioxide is controlled within the range of 0.001-0.004g/h, so that the sustained-release and sterilization effects are better. When the mass ratio is 0.5, i.e. the addition amount of the carrier A is small, the contact probability of chlorite and strong acid salt in weak base is increased, so that the chlorine dioxide is released too quickly. Similarly, when the mass ratio is 1.5, i.e., the amount of carrier a added is large, the probability of contact of chlorite with strong acid salt in weak base is reduced, and thus the release rate of chlorine dioxide is too slow.
Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present application, and are not limiting thereof; although the present application has been described in detail with reference to the foregoing embodiments, it should be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit and scope of the corresponding technical solutions.
Claims (10)
1. An activation-free slow-release air disinfectant is characterized in that: comprises the following components in percentage by weight: 1-30% of chlorite, 5-98% of carrier and the balance of strong acid salt in weak base;
the molar ratio of the hydrogen ions released by the complete hydrolysis of the strong acid salt in the weak base to the chlorite ions released by the complete hydrolysis of the chlorite is 4:5.
2. The activation-free slow release air disinfectant of claim 1, wherein: the chlorite is one or more selected from sodium chlorite, magnesium chlorite, potassium chlorite, ammonium chlorite and calcium chlorite; the particle size of the chlorite is smaller than 40 meshes.
3. The activation-free slow release air disinfectant of claim 1, wherein: the strong acid salt in the weak base is one or more selected from calcium chloride, zinc chloride, magnesium chloride, aluminum potassium sulfate, aluminum sodium sulfate, aluminum ammonium sulfate, zinc sulfate, magnesium sulfate, calcium phosphate, magnesium phosphate, zinc phosphate and aluminum phosphate; the particle size of the strong acid salt in the weak base is smaller than 40 meshes.
4. The activation-free slow release air disinfectant of claim 1, wherein: the carrier comprises a carrier A and a carrier B;
the carrier A is one or more selected from diatomite, bentonite, sodium sulfate and sea salt;
the carrier B is one or more selected from kaolin, diatomite and volcanic ash.
5. The activation-free slow release air disinfectant of claim 4, wherein: the mass ratio of the carrier A to the carrier B is 0.7-1.3:1.
6. the activation-free slow release air disinfectant of claim 4, wherein: the particle size of the carrier A and the carrier B is less than or equal to 60 meshes, and the moisture content of the carrier A and the carrier B is less than or equal to 5%.
7. The activation-free slow release air disinfectant of claim 1, wherein: the activation-free slow-release air disinfectant also comprises a fragrance agent; the flavoring agent is one or more selected from Camphora, borneolum Syntheticum, herba Menthae, fructus Citri Limoniae, herba Agastaches, lignum Cinnamomi Camphorae, flos Magnoliae, pericarpium Citri Tangerinae, herba Schizonepetae and their extracts.
8. The activation-free slow release air disinfectant of claim 7, wherein: the grain diameter of the flavoring agent is less than or equal to 60 meshes when the flavoring agent is plant tissue, and the water content is less than or equal to 5%.
9. The method for preparing the activation-free slow-release air disinfectant as set forth in any one of claims 1 to 8, characterized in that: the method comprises the following steps:
(1) Mixing chlorite and carrier A to obtain mixture 1;
(2) Fully mixing strong acid salt in weak base with a carrier B and a flavoring agent to obtain a mixture 2;
(3) And fully and uniformly mixing the mixture 1 and the mixture 2 to obtain the activation-free slow-release air disinfectant.
10. The method of manufacturing according to claim 9, wherein: the mixing in the step (3) refers to mixing in an environment in which the air humidity is lower than 50% and direct sunlight is avoided.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090078911A1 (en) * | 2006-02-17 | 2009-03-26 | Taiko Pharmaceutical Co., Ltd. | Chlorine dioxide generating composition |
| WO2020016728A1 (en) * | 2018-07-16 | 2020-01-23 | Upl Ltd | Gas releasing composition and process of preparation thereof |
| CN113142250A (en) * | 2020-04-15 | 2021-07-23 | 广东爱锝医药技术研究院有限公司 | Air sterilization and disinfection composition |
| CN113662004A (en) * | 2021-08-06 | 2021-11-19 | 哈尔滨理工大学 | Slow-release chlorine dioxide disinfection card using zeolite as carrier |
| CN115462390A (en) * | 2022-08-31 | 2022-12-13 | 中国疾病预防控制中心病毒病预防控制所 | Long-acting slow-release chlorine dioxide and preparation method and application thereof |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090078911A1 (en) * | 2006-02-17 | 2009-03-26 | Taiko Pharmaceutical Co., Ltd. | Chlorine dioxide generating composition |
| WO2020016728A1 (en) * | 2018-07-16 | 2020-01-23 | Upl Ltd | Gas releasing composition and process of preparation thereof |
| CN113142250A (en) * | 2020-04-15 | 2021-07-23 | 广东爱锝医药技术研究院有限公司 | Air sterilization and disinfection composition |
| CN113662004A (en) * | 2021-08-06 | 2021-11-19 | 哈尔滨理工大学 | Slow-release chlorine dioxide disinfection card using zeolite as carrier |
| CN115462390A (en) * | 2022-08-31 | 2022-12-13 | 中国疾病预防控制中心病毒病预防控制所 | Long-acting slow-release chlorine dioxide and preparation method and application thereof |
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