CN115607591A - 一种治疗颈椎/腰间盘/风湿痹症中药组合物及制备方法 - Google Patents
一种治疗颈椎/腰间盘/风湿痹症中药组合物及制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗颈椎/腰间盘/风湿痹症中药组合物及制备方法,涉及中药技术领域,旨在解决骨关节病不易治愈的问题,本发明通过添加马钱子、甘草、乳香、没药、川牛膝、草乌、麻黄、土鳖虫、苍术、僵蚕、全蝎、川乌,使成品具有活血祛淤、祛风除湿、通经活络、强筋健骨、消肿止痛、增强肌张力、营养神经以及恢复神经功能之功效;对腰椎间盘突出症及椎体关节紊乱症引起的坐骨神经痛及其它神经痛,有效率达97.3%,对风湿、类风湿性关节炎,慢性劳损所致腰腿痛疗效颇佳,对中、轻度中风后遗症偏瘫有效率达97.8%;适用于椎间盘突出症、坐骨神经痛、腰肌纤维炎、风湿及类风湿性关节炎、中度或轻度中风偏瘫、劳损性腰腿痛、关节痛及肢体活动受限者。
Description
技术领域
本发明涉及中药技术领域,具体为一种治疗颈椎/腰间盘/风湿痹症中药组合物及制备方法。
背景技术
颈椎病又称颈椎综合征,是颈椎骨关节炎,增生性颈椎炎、颈神经根综合症、颈椎间盘脱出症的总称,是一种以退行性病理改变为基础的疾患,主要由于颈椎长期劳损、骨质增生,或椎间盘脱出,韧带增厚,致使颈椎脊髓、神经根或椎动脉受压,出现一系列功能障碍的临床综合征,表现为颈椎间盘退变本身及其继发性的一系列病理改变,如椎节失稳、松动,髓核突出或脱出,骨刺形成,韧带肥厚和继发的椎管狭窄等,刺激或压迫了邻近神经根、脊髓,椎动脉及颈部交感神经等组织,并引起各种各症状和体征的综合征;颈椎病可分为:颈型颈椎病、神经根型颈椎病、脊髓型颈椎病、椎动脉型颈椎病、交感神经型颈椎病、食管压迫型颈椎病;好发于中老年人,且男性发病略高于女性。
腰间盘分为中央部的髓核,富于弹性的胶状物质,周围部的限位环,由多层纤维软骨环按同心圆排列,颈腰部纤维环前厚后薄,髓核易向后外侧脱出,突入椎管或椎间孔,压迫脊髓或脊神经,即椎间盘突出症;腰间盘突出症的科学定义为:纤维环破裂后髓核突出压迫神经根造成以腰腿痛为主要表现的疾病,腰间盘突出症是临床上较为常见的腰部疾患之一,是骨伤科的常见病、多发病:腰间盘相当于一个微动关节,是由透明软骨板、限位环和髓核组成,分布在腰椎骨间,由于脊髓由间盘的后方经过,当突出的间盘压迫脊神经或马尾神经引起腰腿痛或大小便失禁、甚至引起瘫痪时,就称为腰间盘突出症;患有腰间盘突出症首先要注意改变生活方式,不适宜穿带跟的鞋,有条件的可以选择负跟鞋;日常生活中应多睡硬板床,可以减少椎间盘承受的压力。
风湿痹症是指风湿性关节炎,分为寒湿痹症和湿热痹症两种相对的证型,患者一般会出现关节疼痛,行动不便等症状,全身性症状表现为口干、口苦、发热、局部皮温增高、舌苔厚腻、脉象滑数或浮数等。
大部分工作中都需要用到身体的各种部位,例如工地的工人,就经常要用到腰部的力量,即使是在办公室中工作,久坐也会对颈椎、腰椎等造成损害,因此,随着人体年龄的增长,颈椎病、腰椎病及风湿痹症的患病率逐年增加,近年来发病年纪更是逐渐年轻化,成为骨科的常见病和多发病;常见的治疗方式有两种,一种是西医,治疗过程中多使用以化学合成的止疼药、脱水消肿药以及激素类药物以及免疫抑制剂药物治疗为主,但是基本上治标不治本,停药后不仅容易复发,而且成本较高、药物毒副作用较大,若进行手术治疗,一旦失败就有可能造成不可逆的终身伤害;另一种是中医,治疗过程中多采用针灸推拿牵引等方式,仅能起到辅助药物治疗的作用,一旦失手也有可能加重病情;相对来说,中医药治疗更为简单易行,同时标本兼治,风险小,费用低,不易复发,为此,设计一种能够治疗颈椎、腰间盘及风湿痹症的中药是势在必行的。
发明内容
鉴于现有技术中所存在的问题,本发明公开了一种治疗颈椎/腰间盘/风湿痹症中药组合物,采用的技术方案是,包括以下重量份的组分:7-80份马钱子、4-12份甘草、4-12份乳香、4-12份没药、4-12份川牛膝、4-12份草乌、4-12份麻黄、4-12份土鳖虫、4-12份苍术、4-12份僵蚕、4-12份全蝎、4-12份川乌;马钱子种子极毒,主要含有马钱子碱和番木鳖碱等多种生物碱,用于健胃药,中医学上以种子炮制后入药,性寒,味苦,有通络散结,消肿止痛之效,西医学上用种子提取物,作中枢神经兴奋剂;甘草可用于心气虚,心悸怔忡,脉结代,以及脾胃气虚,倦怠乏力,痈疽疮疡、咽喉肿痛,气喘咳嗽,胃痛、腹痛及腓肠肌挛急疼痛,调和某些药物的烈性,还有抗炎,抗过敏作用,能保护发炎的咽喉和气管粘膜;乳香具有镇痛、抑菌的作用;没药可治跌打损伤、金疮、筋骨、心腹诸痛、症瘕、经闭、痈疽肿痛、痔漏、目障;川牛膝可逐瘀通经,通利关节,利尿通淋;草乌可祛风除湿,温经止痛;麻黄可发汗解表,宣肺平喘,利水消肿;土鳖虫可抗凝血以及调脂;苍术可燥湿健脾,祛风散寒,明目,辟秽;僵蚕可祛风解痉,化痰散结;全蝎可息风镇痉,攻毒散结,通络止痛;川乌可祛风除湿,温经止痛。
本发明还公开了上述中药组合物的制备方法,包括以下步骤:
步骤一:马钱子、甘草采用砂烫法炒制,使药物质地酥脆,利于调剂,煎煮及服用,降低某些药物的毒性,便于除去非药用部分,矫味;乳香、没药采用醋炒制,使中药的有效成分更容易煎出并增强药物的归经治疗作用;川牛膝、草乌采用盐炒制,可以增强润下利水的作用,引药入肾,增强其益肝肾的作用,增强滋阴降火的作用;麻黄、土鳖虫取干燥原材料采用文火炒制,有利于煎出药效和捣碎,可增强其消导作用,有利于保持药材质量;苍术、僵蚕采用麸炒,可以起到增强健脾效果、缓和药性以及矫臭的作用;全蝎采用微炒,更容易发挥药效;川乌采用米炒,可以增强药物的健脾止泻作用,降低药物的毒性,矫正不良气味,使药物受热均匀;
步骤二:将步骤一中炒好的各原料分别经150-200目粉碎备用,增加了药物的表面积,促进药物熔解,有利于制备各种药物剂型,加速药材中有效成分的溶解,便于调配、服用和发挥药效,便于药材的快速干燥以及之后的贮存;
步骤三:从步骤二中各种粉碎后的原料内,取出预定份数的各种药材并混合,加入总重量的4-6倍清水,煮沸后继续加热40-60分钟,滤出药液,药渣再次加入总重量的4-6倍清水,煮沸后继续加热40-60分钟,滤出药渣,经过两次水煮,可以尽可能多地提取出药材中的有效成分,将两次滤出的药液加热浓缩至每毫升含生药3-5克,得到流浸膏,药效更好;
步骤四:将步骤三中的所述流浸膏与步骤二中获得的各药粉混合成软膏状,经加热灭菌烘干,制成不同剂型的中药。
作为本发明的一种优选技术方案,所述步骤一中,
马钱子的炒制过程为:将砂置置热锅内,武火加热至240-250℃,投入制马钱子,不断翻炒,至棕褐色,表面鼓起,内部红褐色,并起小泡,取出,筛除沙子,放凉,马钱子中含多种生物碱,包括马钱子碱及番木鳖碱,具大毒,一般含量在1.5%—2.1%左右,个别最高达5%,须炮制后入药,番木鳖碱在268-
290℃高温时溶解分解,本发明采用砂烫法能破坏番木鳖碱,但温度高低不同而破坏的程度不同,温度过高则对番木鳖碱破坏性太大,起不到治疗作用,本发明创新性将砂烫法温度控制在240-250℃之间,既节约油料,又易于粉碎,便于制药和服用,又不破坏马钱子碱及番木鳖碱的含量;
甘草的炒制过程为:将砂置置热锅内,文火加热至85-95℃,投入甘草,不断翻炒,至黄色或者深黄色时取出,筛除沙子,放凉。
作为本发明的一种优选技术方案,所述步骤一中的醋炒过程为:先分别拣去乳香和没药中的杂质,破碎,再分别置锅内文火炒制至表面熔化起泡或者膨胀鼓起时,喷洒米醋,继续炒制外层明亮光透,取出放凉;其中,每100质量份乳香或没药,喷洒6质量份的米醋。
作为本发明的一种优选技术方案,所述步骤一中的盐炒过程为:将原料加入食盐水中搅拌均匀,待食盐水被吸进后文火炒干,取出炒熟的原料放凉;其中,每100质量份的原料,用2质量份的食盐。
作为本发明的一种优选技术方案,所述步骤一种,
麻黄的炒制过程为:取麻黄干燥原材料,去除杂质,筛去灰屑,置炒锅内,文火加热至85-95℃,不断翻炒,至麻黄不黏手时取出,放凉;
土鳖虫的炒制过程为:取土鳖虫原材料,去除杂质,筛去灰屑,置炒锅内,文火加热至85-95℃,不断翻炒,至微焦时取出,放凉。
作为本发明的一种优选技术方案,所述步骤一中的麸炒过程为:用武火将锅烧热,撒入麦麸至起烟时,投入药材,不断翻动并适当控制火力,炒到药材表面呈米黄色或深黄色时取出,筛去麸皮放凉;其中,每100质量份的原料,用10-15质量份的麦麸。
作为本发明的一种优选技术方案,所述步骤一中的全蝎在微炒之前,首先要去足,并用热水洗去盐毒。
作为本发明的一种优选技术方案,所述步骤一中的米炒过程为:先将锅烧热,撒上浸湿的米,使其平贴锅上,中火加热炒至米冒烟时投入药物,轻轻翻动米上药材,至需要的程度取出,筛去米,放凉;其中,每100质量份的原料,用20质量份的麦麸。
作为本发明的一种优选技术方案,所述步骤四中,
加热灭菌烘干的具体操作过程为:将粉碎后的原料药与制作的流浸膏混合成软膏状,置于灭菌盘中,均匀铺开,厚度不超过1cm,再将灭菌盘送入干热灭菌柜中进行干燥灭菌,干燥灭菌的温度为80-250℃,干燥灭菌的时间为0.75—4h;一般情况下,干热灭菌温度为80℃,要求干燥灭菌4小时;干热灭菌温度为160-170℃,要求灭菌120分钟以上;干热灭菌温度为170-180℃,要求灭菌60分钟以上;干热灭菌温度为温度大于250℃,要求灭菌约45分钟;
剂型是指选择水丸剂、蜜丸剂、胶囊剂中的一种或几种,所述剂型选用胶囊剂,乳香和没药中含大量挥发油成份,气味难闻,马钱子中含马钱子碱和番木鳖碱,也具有强烈苦味,若制成丸剂或者汤剂口服可引起恶心或者呕吐,因此胶囊剂较丸剂更为合理。
本发明的有益效果:本发明通过在中药组合物中添加马钱子、甘草、乳香、没药、川牛膝、草乌、麻黄、土鳖虫、苍术、僵蚕、全蝎、川乌,使得制出的成品药剂具有活血祛淤、祛风除湿、通经活络、强筋健骨、消肿止痛、增强肌张力、营养神经以及恢复神经功能之功效;对腰椎间盘突出症及椎体关节紊乱症引起的坐骨神经痛及其它神经痛,有效率达97.3%,对风湿、类风湿性关节炎,慢性劳损所致腰腿痛疗效颇佳,对中、轻度中风后遗症偏瘫有效率达97.8%;适用于椎间盘脱出症、坐骨神经痛、腰肌纤维炎、风湿及类风湿性关节炎、中度或轻度中风偏瘫、劳损性腰腿痛、关节痛及肢体活动受限者。
具体实施方式
实施例1
本发明公开了一种治疗颈椎/腰间盘/风湿痹症中药组合物,采用的技术方案是,包括以下重量份的组分:
120g马钱子、18g甘草、18g乳香、18g没药、18g川牛膝、18g草乌、18g麻黄、18g土鳖虫、18g苍术、18g僵蚕、18g全蝎、18g川乌;马钱子种子极毒,主要含有马钱子碱和番木鳖碱等多种生物碱,用于健胃药,中医学上以种子炮制后入药,性寒,味苦,有通络散结,消肿止痛之效,西医学上用种子提取物,作中枢神经兴奋剂;甘草可用于心气虚,心悸怔忡,脉结代,以及脾胃气虚,倦怠乏力,痈疽疮疡、咽喉肿痛,气喘咳嗽,胃痛、腹痛及腓肠肌挛急疼痛,调和某些药物的烈性,还有抗炎,抗过敏作用,能保护发炎的咽喉和气管粘膜;乳香具有镇痛、抑菌的作用;没药可治跌打损伤、金疮、筋骨、心腹诸痛、症瘕、经闭、痈疽肿痛、痔漏、目障;川牛膝可逐瘀通经,通利关节,利尿通淋;草乌可祛风除湿,温经止痛;麻黄可发汗解表,宣肺平喘,利水消肿;土鳖虫可抗凝血以及调脂;苍术可燥湿健脾,祛风散寒,明目,辟秽;僵蚕可祛风解痉,化痰散结;全蝎可息风镇痉,攻毒散结,通络止痛;川乌可祛风除湿,温经止痛。
本发明还公开了上述中药组合物的制备方法,包括以下步骤:
步骤一:马钱子、甘草采用砂烫法炒制,使药物质地酥脆,利于调剂,煎煮及服用,降低某些药物的毒性,便于除去非药用部分,矫味;乳香、没药采用醋炒制,使中药的有效成分更容易煎出并增强药物的归经治疗作用;川牛膝、草乌采用盐炒制,可以增强润下利水的作用,引药入肾,增强其益肝肾的作用,增强滋阴降火的作用;麻黄、土鳖虫取干燥原材料采用文火炒制,有利于煎出药效和捣碎,可增强其消导作用,有利于保持药材质量;苍术、僵蚕采用麸炒,可以起到增强健脾效果、缓和药性以及矫臭的作用;全蝎采用微炒,更容易发挥药效;川乌采用米炒,可以增强药物的健脾止泻作用,降低药物的毒性,矫正不良气味,使药物受热均匀;
步骤二:将步骤一中炒好的各原料分别经200目粉碎备用,增加了药物的表面积,促进药物熔解,有利于制备各种药物剂型,加速药材中有效成分的溶解,便于调配、服用和发挥药效,便于药材的快速干燥以及之后的贮存;
步骤三:从步骤二中各种粉碎后的原料内,取出预定份数的各种药材并混合,加入总重量的5倍清水,煮沸后继续加热50分钟,滤出药液,药渣再次加入总重量的5倍清水,煮沸后继续加热50分钟,滤出药渣,经过两次水煮,可以尽可能多地提取出药材中的有效成分,将两次滤出的药液加热浓缩至每毫升含生药4克,得到流浸膏,药效更好;
步骤四:将步骤三中的所述流浸膏与步骤二中获得的各药粉混合成软膏状,经加热灭菌烘干,制成不同剂型的中药;所述剂型选用胶囊剂,乳香和没药中含大量挥发油成份,气味难闻,马钱子中含马钱子碱和番木鳖碱,也具有强烈苦味,若制成丸剂或者汤剂口服可引起恶心或者呕吐,因此胶囊剂较丸剂更为合理。
作为本发明的一种优选技术方案,所述步骤一中,
马钱子的炒制过程为:将砂置置热锅内,武火加热至250℃,投入制马钱子,不断翻炒,至棕褐色,表面鼓起,内部红褐色,并起小泡,取出,筛除沙子,放凉,马钱子中含多种生物碱,包括马钱子碱及番木鳖碱,具大毒,一般含量在1.5%—2.1%左右,个别最高达5%,须炮制后入药,番木鳖碱在268-290℃高温时溶解分解,本发明采用砂烫法能破坏番木鳖碱,但温度高低不同而破坏的程度不同,温度过高则对番木鳖碱破坏性太大,起不到治疗作用,本发明创新性将砂烫法温度控制在250℃,既节约油料,又易于粉碎,便于制药和服用,又不破坏马钱子碱及番木鳖碱的含量;
甘草的炒制过程为:将砂置置热锅内,文火加热至95℃,投入甘草,不断翻炒,至黄色或者深黄色时取出,筛除沙子,放凉。
作为本发明的一种优选技术方案,所述步骤一中的醋炒过程为:先分别拣去乳香和没药中的杂质,破碎,再分别置锅内文火炒制至表面熔化起泡或者膨胀鼓起时,喷洒米醋,继续炒制外层明亮光透,取出放凉;其中,每100质量份乳香或没药,喷洒6质量份的米醋。
作为本发明的一种优选技术方案,所述步骤一中的盐炒过程为:将原料加入食盐水中搅拌均匀,待食盐水被吸进后文火炒干,取出炒熟的原料放凉;其中,每100质量份的原料,用2质量份的食盐。
作为本发明的一种优选技术方案,所述步骤一种,
麻黄的炒制过程为:取麻黄干燥原材料,去除杂质,筛去灰屑,置炒锅内,文火加热至95℃,不断翻炒,至麻黄不黏手时取出,放凉;
土鳖虫的炒制过程为:取土鳖虫原材料,去除杂质,筛去灰屑,置炒锅内,文火加热至95℃,不断翻炒,至微焦时取出,放凉。
作为本发明的一种优选技术方案,所述步骤一中的麸炒过程为:用武火将锅烧热,撒入麦麸至起烟时,投入药材,不断翻动并适当控制火力,炒到药材表面呈米黄色或深黄色时取出,筛去麸皮放凉;其中,每100质量份的原料,用15质量份的麦麸。
作为本发明的一种优选技术方案,所述步骤一中的全蝎在微炒之前,首先要去足,并用热水洗去盐毒。
作为本发明的一种优选技术方案,所述步骤一中的米炒过程为:先将锅烧热,撒上浸湿的米,使其平贴锅上,中火加热炒至米冒烟时投入药物,轻轻翻动米上药材,至需要的程度取出,筛去米,放凉;其中,每100质量份的原料,用20质量份的麦麸。
作为本发明的一种优选技术方案,所述步骤四中,
加热灭菌烘干的具体操作过程为:将粉碎后的原料药与制作的流浸膏混合成软膏状,置于灭菌盘中,均匀铺开,厚度为0.9cm,再将灭菌盘送入干热灭菌柜中进行干燥灭菌,干燥灭菌的温度为175℃,干燥灭菌的时间为1h;干燥灭菌后药物呈干块状,抓之易碎,再将干燥灭菌后的药物过200目筛,最后制成0.25g/粒的胶囊。
下面对本发明的药物组方在临床经验效果上进行进一步说明:
临床资料:
本发明人自1996年至今对569例颈椎、腰椎间盘突出、骨质增生、类风湿关节炎患者进行临床观察治疗后随访,年龄25岁-80岁,病程1-30年不等。
治疗方法:
成人口服本实施例的胶囊,每日一次,首次5-6粒,每粒0.25g,夜间睡前空腹用黄酒送服,三十天为一疗程,由于骨关节毛病均是慢性疾病,一般需2-3个疗程治愈。
结果:
临床治愈398例,占70%;显效182例,占32%;有效483例,占85%;无效28例,占5%;总有效率95%。
其中,判定标准为:
痊愈:临床症状及体征消失,关节肌肉功能活动恢复正常;
显效:临床症状及体征基本或者大部分消失;
有效:临床症状明显好转;
无效:临床症状无改善。
下面通过几个典型病例对本发明药物的疗效进行进一步说明:
病例1、谌某祥,男,58岁,银行工作人员,体重76KG,湖南省人,患者颈椎病反复发作6年,加重时,工作生活不能自理近2年,患者四年前反复发作颈椎痛,伴左上肢及右下肢疼痛,当时自觉可以忍受,两年前症状逐渐加重,上下楼梯及下蹲起立困难,眼冒金花,经湖南怀化市第二人民医院CT检查提示为颈椎病,颈椎退变,服用本发明中药制剂一个半月后症状日渐好转,两个月后基本治愈症状消失,随访两年无复发。
病例2、舒某华,男,50岁,中学教师,体重75Kg,湖南省人,经溆浦县人民医院CT提示患腰椎间盘突出症,骨质增生,椎管狭窄,引起腰腿痛不能行走站立,卧床后翻身困难,弯腰下蹲起立困难。服用本发明的药物2个疗程后,症状明显缓解,三个疗程后症状消失,行动自如,随访两年无复发。
病例3、成某国,男,72岁,湖南省人,患类风湿关节炎二十余年,双膝关节、踝关节、掌指关节肿胀晨僵,尤以左膝关节为甚,发作时左膝关节不能弯曲,下蹲及行走困难,服用本发明的药物3个疗程后,双膝关节及掌指关节肿胀明显消退,左膝关节弯曲活动自如,行动自如,随访一年无复发。
病例4、董某安,女,52岁,工人,体重56Kg,湖南省人,患类风湿关节炎,骨质增生。腰疼腿疼,双手掌指关节肿痛,晨僵,左肩关节上抬困难,双手不能握紧,左、右手指尖麻木,右手更厉害不能反至后背,服用本发明的药物2个月后腰痛腿痛症状缓解,三个月后关节肿胀消退,双肩关节可平行举过头顶,搭肩及反手动作自如,随访一年无复发。
病例5、凌某花,女,45岁,体重65Kg,湖南省人,患者36岁时患腰椎间盘突出症,腰椎骨质增生,腰痛伴右下肢胀痛,不能起床,不能行走,弯腰下蹲困难,腰部不能支撑自身重量,右下肢麻木。服用本发明药物2个月后症状缓解,三个半月后完全治愈,弯腰行动自如,随访近5年无复发。
病例6、王某兰,女,64岁,体重54Kg,湖南省人,患者50岁时患腰椎间盘突出症、骨质增生、椎管狭窄;双侧腰痛腿痛,伴下肢放射痛,足背部麻木,脚趾尖麻木,不能正常行走,平日里跛行,腰部不能伸直,不能久坐久站,起床及下蹲需人搀扶。服用本发明药物两个月后腰痛腿痛症状缓解,半年后治愈症状完全消失,随访至今无复发。
病例7、李某江,男,53岁,装修工人,体重62.5KG,湖南省人,患者颈痛腰痛反复发作四年,加重生活不能自理3年,患者四年前反复发作颈痛腰痛,伴左上肢及右下肢疼痛,当时自觉可以忍受,两年前症状逐渐加重,腰部不能支撑身体重量,需拄拐行动,腰部不能伸直,不能行走,上下楼梯及下蹲起立困难,经平江县人民医院多次照片检查示颈椎病,腰椎病,椎间盘突出伴椎管狭窄,颈腰椎退变,服用本发明中药制剂一个半月后症状日渐好转,两个月后基本治愈症状消失,随访两年无复发。
病例8、沈某洁,女,27岁,体重51Kg,湖南省人,患腰椎间盘突出症,椎管狭窄引起腰腿痛不能行走站立,卧床后翻身困难,弯腰下蹲起立困难。服用本发明的药物一个疗程症状明显缓解,两个疗程后症状消失,行动自如,随访两年无复发。
病例9、朱某,女,37岁,体重55Kg,湖南省人,患腰椎间盘突出症,引起腰腿痛不能行走站立,卧床后翻身困难,弯腰下蹲起立困难。服用本发明的药物一个疗程症状明显缓解,两个疗程后症状消失,行动自如,随访两年无复发。
病例10、戴某民,男,49岁,体重67.5Kg,经湖南中医院大学第一附属医院磁共振诊断,患腰椎间盘突出症,间歇性跛行,不能弯腰,不能久坐,久站,久走,服用本发明的药物15天后症状缓解,一个疗程后基本治愈,随访一年无复发。
本文中未详细说明的部件为现有技术。
上述虽然对本发明的具体实施例作了详细说明,但是本发明并不限于上述实施例,在本领域普通技术人员所具备的知识范围内,还可以在不脱离本发明宗旨的前提下做出各种变化,而不具备创造性劳动的修改或变形仍在本发明的保护范围以内。
Claims (10)
1.一种治疗颈椎/腰间盘/风湿痹症中药组合物,其特征在于:包括以下重量份的组分:
7-80份马钱子、4-12份甘草、4-12份乳香、4-12份没药、4-12份川牛膝、4-12份草乌、4-12份麻黄、4-12份土鳖虫、4-12份苍术、4-12份僵蚕、4-12份全蝎、4-12份川乌。
2.一种如权利要求1所述的中药的制备方法,其特征在于:包括以下步骤:
步骤一:马钱子、甘草采用砂烫法炒制;乳香、没药采用醋炒制;川牛膝、草乌采用盐炒制;麻黄、土鳖虫取干燥原材料采用文火炒制;苍术、僵蚕采用麸炒;全蝎采用微炒;川乌采用米炒;
步骤二:将步骤一中炒好的各原料分别经150-200目粉碎备用;
步骤三:从步骤二中各种粉碎后的原料内,取出预定份数的各种药材并混合,加入总重量的4-6倍清水,煮沸后继续加热40-60分钟,滤出药液,药渣再次加入总重量的4-6倍清水,煮沸后继续加热40-60分钟,滤出药渣,将两次滤出的药液加热浓缩至每毫升含生药3-5克,得到流浸膏;
步骤四:将步骤三中的所述流浸膏与步骤二中获得的各药粉混合成软膏状,经加热灭菌烘干,制成不同剂型的中药。
3.根据权利要求2所述的制备方法,其特征在于:所述步骤一中,
马钱子的炒制过程为:将砂置置热锅内,武火加热至240-250℃,投入制马钱子,不断翻炒,至棕褐色,表面鼓起,内部红褐色,并起小泡,取出,筛除沙子,放凉;
甘草的炒制过程为:将砂置置热锅内,文火加热至85-95℃,投入甘草,不断翻炒,至黄色或者深黄色时取出,筛除沙子,放凉。
4.根据权利要求2所述的制备方法,其特征在于:所述步骤一中的醋炒过程为:先分别拣去乳香和没药中的杂质,破碎,再分别置锅内文火炒制至表面熔化起泡或者膨胀鼓起时,喷洒米醋,继续炒制外层明亮光透,取出放凉;其中,每100质量份乳香或没药,喷洒6质量份的米醋。
5.根据权利要求2所述的制备方法,其特征在于:所述步骤一中的盐炒过程为:将原料加入食盐水中搅拌均匀,待食盐水被吸进后文火炒干,取出炒熟的原料放凉;其中,每100质量份的原料,用2质量份的食盐。
6.根据权利要求2所述的制备方法,其特征在于:所述步骤一中,
麻黄的炒制过程为:取麻黄干燥原材料,去除杂质,筛去灰屑,置炒锅内,文火加热至85-95℃,不断翻炒,至麻黄不黏手时取出,放凉;
土鳖虫的炒制过程为:取土鳖虫原材料,去除杂质,筛去灰屑,置炒锅内,文火加热至85-95℃,不断翻炒,至微焦时取出,放凉。
7.根据权利要求2所述的制备方法,其特征在于:所述步骤一中的麸炒过程为:用武火将锅烧热,撒入麦麸至起烟时,投入药材,不断翻动并适当控制火力,炒到药材表面呈米黄色或深黄色时取出,筛去麸皮放凉;其中,每100质量份的原料,用10-15质量份的麦麸。
8.根据权利要求2所述的制备方法,其特征在于:所述步骤一中的全蝎在微炒之前,首先要去足,并用热水洗去盐毒。
9.根据权利要求2所述的制备方法,其特征在于:所述步骤一中的米炒过程为:先将锅烧热,撒上浸湿的米,使其平贴锅上,中火加热炒至米冒烟时投入药物,轻轻翻动米上药材,至需要的程度取出,筛去米,放凉;其中,每100质量份的原料,用20质量份的麦麸。
10.根据权利要求2所述的制备方法,其特征在于:所述步骤四中,
加热灭菌烘干的具体操作过程为:将粉碎后的原料药与制作的流浸膏混合成软膏状,置于灭菌盘中,均匀铺开,厚度不超过1cm,再将灭菌盘送入干热灭菌柜中进行干燥灭菌;
剂型是指选择水丸剂、蜜丸剂、胶囊剂中的一种或几种。
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