CN115590985A - Sterile medical ultrasonic coupling agent and preparation method thereof - Google Patents
Sterile medical ultrasonic coupling agent and preparation method thereof Download PDFInfo
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- CN115590985A CN115590985A CN202111578921.2A CN202111578921A CN115590985A CN 115590985 A CN115590985 A CN 115590985A CN 202111578921 A CN202111578921 A CN 202111578921A CN 115590985 A CN115590985 A CN 115590985A
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- medical ultrasonic
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- 238000002360 preparation method Methods 0.000 title abstract description 14
- 239000007822 coupling agent Substances 0.000 title abstract description 10
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000004202 carbamide Substances 0.000 claims abstract description 15
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 12
- 229960001631 carbomer Drugs 0.000 claims abstract description 12
- 108010046334 Urease Proteins 0.000 claims abstract description 10
- 239000008213 purified water Substances 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000003906 humectant Substances 0.000 claims abstract description 6
- 239000003755 preservative agent Substances 0.000 claims abstract description 5
- 230000002335 preservative effect Effects 0.000 claims abstract description 5
- 238000000034 method Methods 0.000 claims abstract description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- 238000003756 stirring Methods 0.000 claims description 10
- 230000008719 thickening Effects 0.000 claims description 8
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 4
- 229960005323 phenoxyethanol Drugs 0.000 claims description 4
- 238000005303 weighing Methods 0.000 claims description 4
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 239000003349 gelling agent Substances 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 239000000080 wetting agent Substances 0.000 claims description 2
- 238000002604 ultrasonography Methods 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 230000001954 sterilising effect Effects 0.000 abstract description 8
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 6
- 230000001050 lubricating effect Effects 0.000 abstract description 4
- GUTLYIVDDKVIGB-OUBTZVSYSA-N Cobalt-60 Chemical compound [60Co] GUTLYIVDDKVIGB-OUBTZVSYSA-N 0.000 abstract description 3
- 230000008569 process Effects 0.000 abstract description 3
- 238000003384 imaging method Methods 0.000 abstract description 2
- 231100000344 non-irritating Toxicity 0.000 abstract description 2
- 231100000252 nontoxic Toxicity 0.000 abstract description 2
- 230000003000 nontoxic effect Effects 0.000 abstract description 2
- 230000000694 effects Effects 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 238000000354 decomposition reaction Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- ZEYHEAKUIGZSGI-UHFFFAOYSA-N 4-methoxybenzoic acid Chemical compound COC1=CC=C(C(O)=O)C=C1 ZEYHEAKUIGZSGI-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 239000003899 bactericide agent Substances 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 230000036512 infertility Effects 0.000 description 2
- VVOAZFWZEDHOOU-UHFFFAOYSA-N magnolol Chemical compound OC1=CC=C(CC=C)C=C1C1=CC(CC=C)=CC=C1O VVOAZFWZEDHOOU-UHFFFAOYSA-N 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- JMSVCTWVEWCHDZ-UHFFFAOYSA-N syringic acid Chemical compound COC1=CC(C(O)=O)=CC(OC)=C1O JMSVCTWVEWCHDZ-UHFFFAOYSA-N 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 239000000341 volatile oil Substances 0.000 description 2
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 description 1
- 229910000013 Ammonium bicarbonate Inorganic materials 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 101100515516 Arabidopsis thaliana XI-H gene Proteins 0.000 description 1
- 229920000832 Cutin Polymers 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 235000012538 ammonium bicarbonate Nutrition 0.000 description 1
- 239000001099 ammonium carbonate Substances 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000007872 degassing Methods 0.000 description 1
- 238000002059 diagnostic imaging Methods 0.000 description 1
- 238000012631 diagnostic technique Methods 0.000 description 1
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- YIBXWXOYFGZLRU-UHFFFAOYSA-N syringic aldehyde Natural products CC12CCC(C3(CCC(=O)C(C)(C)C3CC=3)C)C=3C1(C)CCC2C1COC(C)(C)C(O)C(O)C1 YIBXWXOYFGZLRU-UHFFFAOYSA-N 0.000 description 1
- 230000009974 thixotropic effect Effects 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Acoustics & Sound (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a sterile medical ultrasonic couplant and a preparation method thereof, wherein the sterile medical ultrasonic couplant comprises the following components: 0.3-0.8% of carbomer, 5-15% of humectant, 0.1-1% of preservative, 0.5-5% of urea, 0.001-0.01% of urease and the balance of purified water. The invention also discloses a preparation method of the sterile medical ultrasonic coupling agent. The sterile medical ultrasonic couplant is colorless, nontoxic, non-irritating, good in thermal stability, good in lubricating property and clear in ultrasonic imaging, and can meet various requirements of the sterile medical ultrasonic couplant of medical industry standard YY0299-2016 of medical ultrasonic couplant. In addition, the sterile medical ultrasonic coupling agent disclosed by the invention is simple in preparation process, free of processes of vacuumizing to remove bubbles, free of cobalt-60 irradiation sterilization and the like, simple in preparation process, low in cost and easy to popularize and apply in the market.
Description
Technical Field
The invention belongs to the technical field of medical ultrasonic diagnosis and detection, and particularly relates to a sterile medical ultrasonic coupling agent and a preparation method thereof.
Technical Field
Medical ultrasonic examination is an ultrasonic-based visual medical imaging diagnostic technique which is started to be applied in the 20 th century, and is widely applied in the current medical science, because ultrasonic waves can generate a reflection phenomenon when being incident on an interface of two different media, and the size of sound energy penetrating into the other medium is reduced, a medium substance is filled between a patient body and a probe to become a necessary means for reducing the loss of the sound energy, the medium substance is called a medical ultrasonic couplant and gradually becomes one of medical supplies which are used most frequently in clinic, and the ultrasonic couplant has multiple performance requirements in practical application: 1. the skin is not stimulated, and the anaphylactic reaction can not be caused after the skin is contacted for a long time; 2. the thixotropic property is good, and air is thoroughly removed; 3. the sound velocity is proper, the attenuation coefficient is small, and the acoustic impedance is moderate, so that the ultrasonic image definition is improved; 4. the lubricating property is good, the viscosity is proper, the flowing is avoided, and the erasing is easy; 5. can moisten skin, and is not easy to dry; 6. the adhesive has thermal stability, and the adhesion force is not reduced under clinical conditions; 7. has no corrosion effect on the ultrasonic probe.
So far, the couplant industry has a medical industry standard YY0299-2016 named medical ultrasonic couplant, which is established in China, and the standard makes specific limits and regulations on classification, application and components of the medical ultrasonic couplant and puts forward related technical requirements and test methods for products.
According to the classification of medical ultrasonic couplants, currently, the types of non-sterile medical ultrasonic couplants in the market are more, most of the non-sterile medical ultrasonic couplants are non-sterile products, and a sterile product is also available, for example, CN105983107A provides a novel medical sterilizing ultrasonic couplant, magnolol is used as a main sterilizing component, and syringic acid, anisic acid, dipotassium glycyrrhizinate and vanillin are used for synergistic sterilization; for example, CN104189927A is compounded by 6 Chinese herbal medicine essential oils to achieve the sterilization effect, the mixed smell of various Chinese herbal medicine essential oils is mixed, and the preparation process is complex; and if the chemical components are taken as bactericides: CN101219223A takes (0.2% -2%) 2, 4-trichloro-2-hydroxydiphenyl ether as a bactericidal component, can not be biodegraded, and the chemical bactericide is added in a large amount, and remains on the skin after ultrasonic diagnosis, and has a certain stimulation effect on the skin.
Meanwhile, the sterile medical ultrasonic couplant meeting the requirements of medical ultrasonic couplant is relatively few.
Disclosure of Invention
Aiming at the defects of the existing medical ultrasonic coupling agent product, the invention provides a sterile medical ultrasonic coupling agent and a preparation method thereof. The invention adopts raw materials meeting the standard requirements and is assisted with a mode of combining physics and chemistry to meet the requirements of medical ultrasonic couplant.
The invention is realized in such a way that a sterile medical ultrasonic coupling agent comprises the following components in percentage by weight:
0.3 to 0.8 percent of carbomer,
5 to 15 percent of humectant,
0.1 to 1 percent of preservative phenoxyethanol
0.5 to 5 percent of urea
Urease 0.001-0.01%
Purified water, balance.
The sterile medical ultrasonic couplant is characterized in that carbomer is a water-soluble gelling agent.
The sterile medical ultrasonic couplant adopts urea as a pH adjusting and skin caring agent.
The sterile medical ultrasonic coupling agent comprises the following components: the wetting agent is one or more of glycerol, propylene glycol and polyethylene glycol.
A preparation method of a sterile medical ultrasonic couplant comprises the following steps:
(1) And weighing carbomer according to the proportion, adding the carbomer into the purified water, and stirring for dissolving for 40-60 minutes to obtain solution A.
(2) And adding the humectant, the preservative and the urea in proportion into the solution A, and uniformly stirring to obtain solution B.
(3) And adding urease into the solution B, stirring for 10 minutes, and standing to obtain solution C.
(4) And filling the solution C, and thickening the filled solution C at the temperature of between 75 and 85 ℃ for 30 to 60 minutes to obtain the sterile medical ultrasonic couplant.
Compared with the prior art, the following test examples prove that the invention has the following advantages:
the invention adopts urea as a pH regulator, and the urea as a skin humectant naturally exists in the horny layer of the skin, belongs to the main component of the natural moisturizing factor NMF of the skin, and has double effects of moisturizing and softening cutin on the skin. The principle of the invention is that urea is decomposed into ammonia and carbon dioxide under the action of urease to finally form ammonium bicarbonate, so that the pH value of the solution is kept between neutral 6.5 and 7.5, thereby achieving the purpose of thickening the system and causing no stimulation to skin.
The invention adopts urease as a decomposition catalyst of urea, the urease is used as absolute specific urea decomposing enzyme which is widely existed in microorganisms and animal and plant tissues, urea can be rapidly catalytically decomposed, simultaneously the activity of the urea can be controlled by pH and temperature, the pH of an initial system is lower than 3.0, the decomposition speed is very slow, and the decomposition speed can be accelerated when the temperature is increased, thereby achieving the purpose of controlling the thickening time and steps.
The invention adopts a production process of firstly filling and then thickening, and the viscosity of the medical ultrasonic couplant is very high, so that the requirement on filling equipment is high in the actual production, and air bubbles are easily generated during filling, so that a degassing device is needed.
The invention adopts a physical and chemical combination mode that the final packaged product is kept for 30-60 minutes at 75-85 ℃ for thickening and sterilization, does not need cobalt-60 irradiation sterilization, reduces the difficulty of aseptic treatment and improves the application range of the product.
The medical ultrasonic couplant can meet various requirements of sterile medical ultrasonic couplants in medical industry standard YY0299-2016 of medical ultrasonic couplant, and is simple in manufacturing process and free of processes of vacuumizing, bubble removing and the like.
Detailed Description
The invention will be further illustrated with reference to the following specific examples. These examples are to be construed as merely illustrative and not limitative of the remainder of the disclosure in any way whatsoever. After reading the description of the invention, one skilled in the art can make various changes and modifications to the invention, and such equivalent changes and modifications also fall into the scope of the invention defined by the claims.
Example 1
The preparation process of the sterile medical ultrasonic couplant comprises the following steps:
(1) 4kg of carbomer is weighed and added into 873kg of purified water to be stirred and dissolved for 40 minutes, so as to obtain solution A.
(2) And (3) weighing 100kg of glycerol, 8kg of phenoxyethanol and 15kg of urea, adding the mixture into the solution A, and uniformly stirring to obtain solution B.
(3) And adding 10g of urease into the solution B, stirring for 10 minutes, and standing to obtain a solution C.
(4) And filling the solution C, and thickening the solution C at 78 ℃ for 60 minutes to obtain the sterile medical ultrasonic couplant.
Example 2
The preparation process of the sterile medical ultrasonic couplant comprises the following steps:
(1) 7kg of carbomer is weighed and added into 900kg of purified water to be stirred and dissolved for 60 minutes, so as to obtain solution A.
(2) And (3) weighing 50kg of glycerol, 3kg of phenoxyethanol and 40kg of urea, adding the mixture into the solution A, and uniformly stirring to obtain a solution B.
(3) And adding 50g of urease into the solution B, stirring for 10 minutes, and standing to obtain a solution C.
(4) And filling the solution C, and thickening the filled solution C at 82 ℃ for 30 minutes to obtain the sterile medical ultrasonic couplant.
Test example 1-microbiological assay:
taking the sterile medical ultrasonic couplant samples in the embodiments, the examination results of appendix XI H (2010 edition) of pharmacopoeia of the people's republic of China (second part) in the "sterility test method" show that blank reference tubes grow aseptically, and the results meet the regulations of sterility test laws.
Test example 2-performance testing:
the main performance of the sterile medical ultrasonic couplant samples taken in the above embodiments is shown by the following detection results: the sound resistance (35 ℃) is 1560-1580 m/s, the sound attenuation (35 ℃) is less than or equal to 0.05 dB/(cm.MHz), the pH value is 6.7-7.2, and all indexes meet the requirements of medical industry standard YY0299-2016 of medical ultrasonic couplant. The ultrasonic probe field simulation experiment shows that: the lubricating property is good, and the image is clear.
In conclusion, the sterile medical ultrasonic couplant is colorless, nontoxic, non-irritating, good in thermal stability, good in lubricating property and clear in ultrasonic imaging, and can meet various requirements of the sterile medical ultrasonic couplant of medical industry standard YY0299-2016 of medical ultrasonic couplant. In addition, the sterile medical ultrasonic coupling agent disclosed by the invention is simple in preparation process, free of processes of vacuumizing to remove bubbles, free of cobalt-60 irradiation sterilization and the like, simple in preparation process, low in cost and easy to popularize and apply in the market.
Claims (4)
1. A sterile medical ultrasonic couplant is characterized by comprising the following components in percentage by weight:
0.3 to 0.8 percent of carbomer,
5 to 15 percent of humectant,
0.1 to 1 percent of preservative phenoxyethanol
0.5 to 5 percent of urea
Urease 0.001-0.01%
Purified water, balance.
2. The sterile medical ultrasonic couplant of claim 1, wherein: the carbomer is a water-soluble gelling agent, and the carboxyl content of the carbomer is 56.0-68.0%.
3. The sterile medical ultrasound couplant of claim 1, wherein: the wetting agent is one or more of glycerol, propylene glycol and polyethylene glycol.
4. A method for preparing the sterile medical ultrasound couplant of any one of claims 1-3, comprising the steps of:
(1) Weighing carbomer according to the proportion, adding the carbomer into purified water, stirring and dissolving for 40-60 minutes to obtain solution A;
(2) Adding the humectant, the preservative and the urea into the solution A in proportion, and uniformly stirring to obtain a solution B;
(3) Adding urease into the solution B, stirring for 10 minutes, and standing to obtain solution C;
(4) And filling the solution C, and thickening the filled solution C at the temperature of between 75 and 85 ℃ for 30 to 60 minutes to obtain the sterile medical ultrasonic couplant.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111578921.2A CN115590985B (en) | 2021-12-22 | 2021-12-22 | Sterile medical ultrasonic coupling agent and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111578921.2A CN115590985B (en) | 2021-12-22 | 2021-12-22 | Sterile medical ultrasonic coupling agent and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN115590985A true CN115590985A (en) | 2023-01-13 |
| CN115590985B CN115590985B (en) | 2024-04-12 |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101966134A (en) * | 2010-09-28 | 2011-02-09 | 广东海洋大学 | Liquid soap with sterilizing and skin protecting functions and preparation method thereof |
| US20130338476A1 (en) * | 2012-06-14 | 2013-12-19 | Seno Medical Instruments, Inc. | Methods and compositions for carrier agents and clearing agents used in optoacoustic imaging systems |
| CN104208726A (en) * | 2014-02-28 | 2014-12-17 | 张维芬 | Chitosan quaternary ammonium salt couplant and preparation method thereof |
| CN104721845A (en) * | 2015-03-13 | 2015-06-24 | 湖北大学 | Disinfecting and sterilizing medical ultrasonic coupling agent with moisturizing and skin-moistening effects and preparation method of disinfecting and sterilizing medical ultrasonic coupling agent |
-
2021
- 2021-12-22 CN CN202111578921.2A patent/CN115590985B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101966134A (en) * | 2010-09-28 | 2011-02-09 | 广东海洋大学 | Liquid soap with sterilizing and skin protecting functions and preparation method thereof |
| US20130338476A1 (en) * | 2012-06-14 | 2013-12-19 | Seno Medical Instruments, Inc. | Methods and compositions for carrier agents and clearing agents used in optoacoustic imaging systems |
| CN104208726A (en) * | 2014-02-28 | 2014-12-17 | 张维芬 | Chitosan quaternary ammonium salt couplant and preparation method thereof |
| CN104721845A (en) * | 2015-03-13 | 2015-06-24 | 湖北大学 | Disinfecting and sterilizing medical ultrasonic coupling agent with moisturizing and skin-moistening effects and preparation method of disinfecting and sterilizing medical ultrasonic coupling agent |
Non-Patent Citations (1)
| Title |
|---|
| 郑增娟等: "卡波姆水凝胶的处方筛选与质量考察", 《医药导报》, vol. 34, no. 2, 28 February 2015 (2015-02-28), pages 244 - 248 * |
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| CN115590985B (en) | 2024-04-12 |
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