CN115581650A - High-safety anti-dandruff composition and preparation method and application thereof - Google Patents
High-safety anti-dandruff composition and preparation method and application thereof Download PDFInfo
- Publication number
- CN115581650A CN115581650A CN202211373579.7A CN202211373579A CN115581650A CN 115581650 A CN115581650 A CN 115581650A CN 202211373579 A CN202211373579 A CN 202211373579A CN 115581650 A CN115581650 A CN 115581650A
- Authority
- CN
- China
- Prior art keywords
- phase
- parts
- mixing
- dandruff
- safety anti
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8188—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bonds, and at least one being terminated by a bond to sulfur or by a hertocyclic ring containing sulfur; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/008—Preparations for oily hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a high-safety anti-dandruff composition which comprises the following components in parts by mass: 2.0-5.0 parts of hydrolyzed chitin, 6.0-10 parts of hydrolyzed corn starch, 0.015-0.025 part of quaternary ammonium salt, 0.1-0.2 part of pricklyash peel fruit extract and water until the total mass is 100 parts. The high-safety anti-dandruff composition disclosed by the invention takes the hydrolyzed chitin as a core component, and combines the quaternary ammonium salt-73, the hydrolyzed corn starch and the zanthoxylum fruit extract, so that the irritation of the high-safety anti-dandruff composition is reduced, the inhibiting capability on malassezia is improved, and the effects of removing dandruff, controlling oil and relieving are achieved.
Description
Technical Field
The invention relates to the field of daily chemicals, in particular to an anti-dandruff composition and a preparation method and application thereof.
Background
The surface of human scalp and the internal structure of scalp form a complete ecosystem, and the surface has secretions, dust, dirt, various bacteria and the like of sebaceous glands. It is generally considered that skin fungi symbiotic with human, such as pityriasis ovalis and the like, enter hair follicles if their growth becomes unbalanced, and anaerobic metabolism increases the rate of decomposition of epidermal cells, resulting in exfoliation and dandruff formation. The generation of dandruff creates conditions for the growth and reproduction of microorganisms, and further stimulates the scalp to cause pruritus. According to an inmitre survey on 3000 internet users aged 18-49 years, 56% of the visitors suffer from dandruff, and 43% of the visitors have scalp itching, so that the problem of dandruff is a common problem in daily life of people.
The addition of a proper anti-dandruff agent with bactericidal and bacteriostatic abilities into shampoo is a main way for preventing and treating dandruff. The common anti-dandruff agents in the existing anti-dandruff shampoo mainly comprise: zinc Pyrithione (ZPT), piroctone olamine salt (OCT), climbazole, ketoconazole, salicylic acid, and the like. Wherein, zinc Pyrithione (ZPT), piroctone olamine salt (OCT), climbazole, ketoconazole and the like belong to powerful bactericides and have the defects of high irritation and environmental unfriendliness, and the European Union forbids Zinc Pyrithione (ZPT) formally at 3 months and 1 days in 2022.
Along with the development of society, the human material culture life is increasingly improved, the safety requirements of people on daily chemicals are higher and higher, particularly the requirements on functional additives are higher and higher, and the additives are required to be safe and nontoxic and to be nutritional and functional. Particularly, in the industries of food, cosmetics and the like, a plurality of safety problems appear in recent years, so that the public has stronger and stronger green, safe and healthy call, and the replacement of the traditional synthetic anti-dandruff agent is increasingly important.
Disclosure of Invention
The primary object of the present invention is to overcome the above-mentioned disadvantages of the prior art and to provide an anti-dandruff composition with high safety.
Another object of the present invention is to provide a method for preparing the anti-dandruff composition with high safety.
It is a further object of the present invention to provide the use of the above-mentioned high-safety anti-dandruff composition.
In order to solve the technical problems, the invention adopts the technical scheme that: a high-safety anti-dandruff composition comprises the following components in parts by mass: 2.0-5.0 parts of hydrolyzed chitin, 6.0-10 parts of hydrolyzed corn starch, 0.015-0.025 part of quaternary ammonium salt, 0.1-0.2 part of pepper fruit extract and water until the total mass is 100 parts.
Preferably, the high-safety anti-dandruff composition comprises the following components in parts by mass: 3.2 parts of hydrolyzed chitin, 8.0 parts of hydrolyzed corn starch, 0.02 part of quaternary ammonium salt-73.02 parts, 0.15 part of pepper fruit extract and water until the total mass part is 100 parts.
Preferably, the high-safety anti-dandruff composition further comprises the following components in parts by mass: 15-20 parts of glycerol, 3.0-6.0 parts of acrylic acid (ester)/acrylamide copolymer and 1.0-3.0 parts of polysorbate-20.
The glycerol and polysorbate-20 adopted by the invention are used for solubilizing quaternary ammonium salt-73; the acrylic acid (ester)/acrylamide copolymer is used as a thickening agent of the anti-dandruff composition.
Preferably, the acrylic acid (ester)/acrylamide copolymer is a binary copolymer of acrylic ester and acrylamide, and the molecular weight is (60-100). Times.10 3 g/mol。
As a preferred scheme, the hydrolyzed chitin is a chitin enzymolysis product, the deacetylation degree is 40-90%, and the viscosity average molecular weight is (0.85-2.64) multiplied by 10 4 g/mol。
Preferably, the quaternary ammonium salt-73 has a molecular structure of
The invention also provides a preparation method of the high-safety anti-dandruff composition, which comprises the following steps:
A. mixing the hydrolyzed chitin with water, adding hydrolyzed corn starch, and mixing to obtain solution 1;
B. and (3) mixing the quaternary ammonium salt-73 with the solution 1 obtained in the step (A), adding the zanthoxylum fruit extract, and mixing to obtain the high-safety anti-dandruff composition.
Preferably, the hydrolyzed chitin and water in step A are mixed by stirring at 100-200rpm at 20-35 deg.C until they are dispersed uniformly.
Preferably, the hydrolyzed corn starch is added and mixed in the step A for 0.5 to 2 hours at 100 to 200 rpm.
Preferably, the quaternary ammonium salt-73 in the step B and the solution 1 are mixed and stirred for 0.5 to 2 hours at 150 to 300 rpm.
Preferably, the zanthoxylum bungeanum maxim extract is added and mixed for 0.5 to 1 hour at 150 to 300 rpm.
Preferably, when the high-safety anti-dandruff composition further comprises glycerol, polysorbate-20 and an acrylic acid/acrylamide copolymer, the preparation method comprises the following steps:
a. mixing hydrolyzed chitin with water, heating, adding acrylic acid (ester)/acrylamide copolymer, cooling to 20-35 deg.C, adding hydrolyzed corn starch, and mixing to obtain solution 1;
b. heating and mixing quaternary ammonium salt-73, glycerol and polysorbate-20 in advance, cooling, mixing with the solution 1 obtained in the step a, adding the zanthoxylum fruit extract, and mixing to obtain the anti-dandruff composition.
Preferably, the heating in step a is heating to 75-85 ℃.
Preferably, the step a of adding the acrylic acid (ester)/acrylamide copolymer is mixing for 4-6h at 150-300 rpm.
Preferably, the temperature reduction in the step a is to be between 65 and 75 ℃.
Preferably, the heating and mixing in the step b is stirring at the temperature of 85-90 ℃ and the rpm of 1000-2000 for 0.5-1h.
Preferably, the temperature reduction in the step b is to be reduced to 65-75 ℃.
The invention also provides application of the high-safety anti-dandruff composition in preparation of hair care products.
The invention also provides a hair care product which comprises the following components in parts by mass:
phase A, which comprises 0.03 to 0.07 part of polyethylene glycol-7M and water, and is complemented until the total mass part of each phase is 100 parts;
phase B, including polyquaternium-10.05-0.15 parts;
phase C, including guar gum hydroxypropyl trimethyl ammonium chloride 0.2-0.4 parts;
phase D, including EDTA disodium 0.05-0.15 parts, citric acid 0.1-0.2 parts;
phase E, including sodium citrate 0.2-0.4;
phase F comprising 8-13 parts of sodium laureth sulfate, 2-4 parts of ammonium laureth sulfate, 0.5-1.5 parts of coconut oil acyl MEA, 0.8-1.5 parts of ethylene glycol distearate and 3-7 parts of amino acid surfactant;
the G phase comprises 0.5-1.5 parts of amphoteric surfactant and 0.2-0.4 part of maleic acid modified castor oil;
phase H, which comprises 1 to 3 parts of the high-safety anti-dandruff composition and 3 to 5 parts of water;
phase I comprising polydimethylsiloxane/water/lauryl alcoholpolyether-23/C 12-15 1.3-2 parts of alkanol polyether-3/phenoxyethanol/ethylhexyl glycerol, 0.3-0.5 part of sodium benzoate, 0.2-0.4 part of phenoxyethanol, 0.05-0.2 part of dichlorobenzyl alcohol/butanediol/cocamidopropyl PG-dimethyl ammonium chloride phosphate sodium, 1-3 parts of daily essence, 0.1-0.3 part of secondary cracking yeast fermentation product filtrate, 0.005-0.015 part of water/butanediol/glycerol/sodium lactate/serine/glycine/alanine/arginine/aspartic acid/valine/isoleucine/leucine/glutamic acid/potassium hydroxide/proline/citric acid;
phase J, including citric acid 0.1-0.3 parts;
and the K phase comprises 0.2-0.5 part of sodium chloride.
Preferably, the amino acid surfactant in phase F is a mixture of 1-3 parts water/sodium methylcocoyl taurate/sodium chloride and 2-4 parts water/potassium cocoyl hydrolyzed oat protein/potassium chloride.
Preferably, the amphoteric surfactant in phase G is water/sodium cocoamidopropyl PG-dimethylammonium chloride phosphate/sodium chloride.
The invention also provides a preparation method of the hair care product, which comprises the following steps:
mixing the S1 phase, the A phase, the B phase and the C phase, heating, adding the D phase and the E phase, heating, preserving heat and defoaming to obtain a mixture 1;
s2, mixing the phase F with the mixture 1 obtained in the step S1, preserving heat, and defoaming to obtain a mixture 2;
s3, cooling, and mixing the phase G with the mixture 2 obtained in the step S2 to obtain a mixture 3;
s4, cooling, and mixing the H phase with the mixture 3 obtained in the step S3 to obtain a mixture 4;
and S5, mixing the phase I with the mixture 4 obtained in the step S4, adding the phase J, adding the phase K, cooling, defoaming and filtering to obtain the hair care product.
Preferably, the step S1 of mixing the phase a, the phase B and the phase C includes mixing the materials of the phase a until uniform, adding the phase B, mixing until uniform, adding the phase C, and dispersing uniformly.
Preferably, the heating temperature in the step S1 is 60-65 ℃, the temperature is increased to 80-85 ℃, and the heat preservation time is 10-15min.
Preferably, the mixing in the step S2 is mixing at 80-85 ℃, and the heat preservation time is 10-15min.
Preferably, the temperature reduction in the step S3 is to be reduced to 55 to 60 ℃.
Preferably, the temperature reduction in step S4 is to be 20 to 45 ℃.
Preferably, the pH adjustment in step S5 is to make the product 10% aqueous solution pH =5.5-6.0.
Compared with the prior art, the embodiment of the invention has the following beneficial effects:
1. the high-safety anti-dandruff composition disclosed by the invention takes the hydrolyzed chitin as a core component, and combines the quaternary ammonium salt-73, the hydrolyzed corn starch and the zanthoxylum fruit extract, so that the irritation of the high-safety anti-dandruff composition is reduced, the inhibiting capability on malassezia is improved, and the effects of removing dandruff, controlling oil and relieving are achieved. Compared with the traditional anti-dandruff agents such as Zinc Pyrithione (ZPT), piroctone olamine salt (OCT), salicylic acid and the like, the high-safety anti-dandruff composition overcomes the defect that the traditional anti-dandruff agent only has an anti-dandruff effect, and when the high-safety anti-dandruff composition is added into a hair care product, the anti-dandruff effect and the safety of the hair care product are superior to those of the hair care product added with the common anti-dandruff agent.
2. The high-safety anti-dandruff composition prepared by the invention can be uniformly distributed in shampoo, has enough contact surface with bacteria and fungi generating scalp during hair washing, and exerts the effect to the maximum extent.
3. The high-safety anti-dandruff composition prepared by the invention can effectively reduce the irritation of a strong irritant surfactant in a hair care product to skin, can reduce the overall irritation of the product, enables the product to be mild and non-irritant, and is suitable for people with various scalp properties.
Drawings
FIG. 1 shows the dandruff index score in example 4 of the effect of the present invention.
FIG. 2 is a schematic diagram of the dandruff evaluation zone in example 4 of the present invention.
Fig. 3 is a graphical representation of scalp oil content test sampling of effect example 5 of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
This example provides a high safety anti-dandruff composition and hair care product.
The high-safety anti-dandruff composition comprises the following components in parts by mass: 0.02 part of quaternary ammonium salt-73.02 parts, 17.5 parts of glycerol, 2.0 parts of polysorbate-20.2 parts, 3.2 parts of hydrolyzed chitin, 64.33 parts of water, 4.8 parts of acrylic acid (ester)/acrylamide copolymer, 8.0 parts of hydrolyzed corn starch and 0.15 part of zanthoxylum fruit extract.
The preparation method of the high-safety anti-dandruff composition comprises the following steps:
stirring quaternary ammonium salt-73, glycerol and polysorbate-20 at 85 ℃ and 1500rpm for 40min, and cooling to 70 ℃ to obtain a solution A;
(II) stirring hydrolyzed chitin and water at 25 ℃ and 150rpm until the hydrolyzed chitin and the water are uniformly dispersed, heating to 80 ℃, adding acrylic acid (ester)/acrylamide copolymer, stirring for 5 hours at 200rpm, cooling to 25 ℃, adding hydrolyzed corn starch, and stirring for 1 hour at 150rpm to obtain a solution B;
(III) stirring the solution A obtained in the step (I) and the solution B obtained in the step (II) at 200rpm for 1h, adding the zanthoxylum bungeanum fruit extract, and continuously stirring for 40min to obtain the high-safety anti-dandruff composition.
The hair care product comprises the components shown in the table 1, and the preparation method comprises the following steps:
s1, stirring the phase A uniformly, mixing the phase A with the phase B, heating the phase A to 63 ℃, adding the phase D and the phase E, heating the phase D to 84 ℃, preserving the heat for 12min, and defoaming to obtain a mixture 1;
s2, stirring the phase F and the mixture 1 obtained in the step S1 at 84 ℃ until the phases are completely and uniformly dissolved, preserving the temperature for 12min, and defoaming to obtain a mixture 2;
s3, cooling to 56 ℃, and fully and uniformly stirring the phase G and the mixture 2 obtained in the step S2 to obtain a mixture 3;
s4, cooling to 45 ℃, and fully and uniformly stirring the H phase and the mixture 3 obtained in the step S3 to obtain a mixture 4;
and S5, uniformly stirring the phase I and the mixture 4 obtained in the step S4, adding the phase J to adjust the pH of a 10% aqueous solution of the product to be =5.6, adding the phase K to adjust the viscosity, cooling to 25 ℃, defoaming and filtering to obtain the hair care product.
The components of the hair care products of the examples and comparative examples are illustrated below:
the water/sodium methyl cocoyl taurate/sodium chloride in the F phase is Runmind provided by Guangzhou Chaihei Biotechnology Ltd TM CT35；
The water/cocoyl hydrolyzed oat protein potassium/potassium chloride/sodium chloride in the F phase is Runmind provided by Guangzhou tide Biotechnology Ltd TM COP NP；
The water/sodium cocoamidopropyl PG-dimethylammonium chloride phosphate/sodium chloride in the G phase is Runsoft provided by Guangzhou tide Biotech Ltd TM PGP；
The polydimethylsiloxane/water/laureth-23/C12-15 alkanol polyether-3/phenoxyethanol/ethylhexyl glycerin in the phase I is RunSI provided by Guangzhou Chaihei Biotechnology Co., ltd TM VA-3060P；
Dichlorobenzyl alcohol/butanediol/cocamidopropyl PG-dimethyl ammonium chloride sodium phosphate in the phase I is a conditioner DX848 plus provided by Guangdong Dimei new material science and technology company Limited;
the secondary split yeast fermentation product Filtrate in the phase I is Rejuvactor Filter Y provided by Dongguan Hua industrial creation and biological science and technology Limited;
phase I provided water/butylene glycol/glycerol/sodium lactate/serine/glycine/alanine/arginine/aspartic acid/valine/isoleucine/leucine/glutamic acid/potassium hydroxide/prolineThe acid/citric acid is provided by Guangzhou Natural Biotechnology Ltd
EPI；
The remaining components are commercially available without specific indication.
TABLE 1 Hair Care product Components of example 1
Example 2
This example provides a high safety anti-dandruff composition and hair care product.
The high-safety anti-dandruff composition comprises the following components in parts by mass: 0.015 part of quaternary ammonium salt, 15 parts of glycerol, 20.0 parts of polysorbate, 2.0 parts of hydrolyzed chitin, 72.885 parts of water, 3.0 parts of acrylic acid (ester)/acrylamide copolymer, 6.0 parts of hydrolyzed corn starch and 0.1 part of zanthoxylum fruit extract.
The preparation method of the high-safety anti-dandruff composition comprises the following steps:
stirring quaternary ammonium salt-73, glycerol and polysorbate-20 at 86 ℃ and 1000rpm for 30min, and cooling to 65 ℃ to obtain a solution A;
(II) stirring hydrolyzed chitin and water at 25 ℃ at 100rpm until the hydrolyzed chitin and the water are uniformly dispersed, heating to 75 ℃, adding acrylic acid (ester)/acrylamide copolymer, stirring for 4 hours at 150rpm, cooling to 25 ℃, adding hydrolyzed corn starch, and stirring for 30 minutes at 100rpm to obtain a solution B;
(III) stirring the solution A in the step (I) and the solution B in the step (II) at 150rpm for 30min, adding the zanthoxylum bungeanum maxim extract, and continuously stirring for 30min to obtain the high-safety anti-dandruff composition.
The hair care product comprises the components shown in the table 2, and the preparation method comprises the following steps:
s1, stirring the phase A to be uniform, mixing the phase A with the phase B, stirring the phase A to be uniform, mixing the phase A with the phase C, heating the mixture to 60 ℃, adding the phase D and the phase E, heating the mixture to 80 ℃, preserving heat for 10min, and defoaming to obtain a mixture 1;
s2, stirring the phase F and the mixture 1 obtained in the step S1 at 80 ℃ until the phase F is completely and uniformly dissolved, preserving the temperature for 10min, and defoaming to obtain a mixture 2;
s3, cooling to 55 ℃, and fully and uniformly stirring the phase G and the mixture 2 obtained in the step S2 to obtain a mixture 3;
s4, cooling to 45 ℃, and fully and uniformly stirring the H phase and the mixture 3 obtained in the step S3 to obtain a mixture 4;
and S5, uniformly stirring the phase I and the mixture 4 obtained in the step S4, adding the phase J to adjust the pH of a 10% aqueous solution of the product to be 5.5, adding the phase K to adjust the viscosity, cooling to 26 ℃, defoaming and filtering to obtain the hair care product.
Table 2 hair care product component formulations of example 2
Example 3
This example provides a high safety anti-dandruff composition and hair care product.
The high-safety anti-dandruff composition comprises the following components in parts by mass: 0.018 parts of quaternary ammonium salt, 18 parts of glycerol, 2.0 parts of polysorbate, 5.0 parts of hydrolyzed chitin, 63.872 parts of water, 4.0 parts of acrylic acid (ester)/acrylamide copolymer, 7.0 parts of hydrolyzed corn starch and 0.11 part of zanthoxylum bungeanum maxim extract.
The preparation method of the high-safety anti-dandruff composition comprises the following steps:
stirring quaternary ammonium salt-73, glycerol and polysorbate-20 at 85 ℃ and 1200rpm for 45min, and cooling to 75 ℃ to obtain a solution A;
(II) stirring the hydrolyzed chitin and water at the temperature of 25 ℃ at 120rpm until the hydrolyzed chitin and the water are uniformly dispersed, heating to 78 ℃, adding the acrylic acid (ester)/acrylamide copolymer, stirring for 4.5 hours at the speed of 180rpm, cooling to 25 ℃, adding the hydrolyzed corn starch, and stirring for 1 hour at the speed of 120rpm to obtain a solution B;
(III) stirring the solution A obtained in the step (I) and the solution B obtained in the step (II) at 180rpm for 1h, adding the zanthoxylum bungeanum fruit extract, and continuously stirring for 45min to obtain the high-safety anti-dandruff composition.
The hair care product comprises the components shown in the table 3, and the preparation method comprises the following steps:
s1, stirring the phase A uniformly, mixing the phase A with the phase B, heating the phase A to 65 ℃, adding the phase D and the phase E, heating the phase D to 85 ℃, preserving the heat for 15min, and defoaming to obtain a mixture 1;
s2, stirring the phase F and the mixture 1 obtained in the step S1 at 85 ℃ until the phase F is completely and uniformly dissolved, preserving the temperature for 15min, and defoaming to obtain a mixture 2;
s3, cooling to 60 ℃, and fully and uniformly stirring the phase G and the mixture 2 obtained in the step S2 to obtain a mixture 3;
s4, cooling to 45 ℃, and fully and uniformly stirring the H phase and the mixture 3 obtained in the step S3 to obtain a mixture 4;
and S5, uniformly stirring the phase I and the mixture 4 obtained in the step S4, adding the phase J to adjust the pH of a 10% aqueous solution of the product to be =6.0, adding the phase K to adjust the viscosity, cooling to 30 ℃, defoaming and filtering to obtain the hair care product.
TABLE 3 formulation of the hair care product components of example 3
Example 4
This example provides a high safety anti-dandruff composition and hair care product.
The high-safety anti-dandruff composition comprises the following components in parts by mass: 0.02 part of quaternary ammonium salt-73.02 parts, 19 parts of glycerol, 2.5 parts of polysorbate-20.0 parts, 3.0 parts of hydrolyzed chitin, 62.33 parts of water, 5.0 parts of acrylic acid (ester)/acrylamide copolymer, 8.0 parts of hydrolyzed corn starch and 0.15 part of zanthoxylum fruit extract.
The preparation method of the high-safety anti-dandruff composition comprises the following steps:
stirring quaternary ammonium salt-73, glycerol and polysorbate-20 at 88 ℃ and 1600rpm for 35min, and cooling to 68 ℃ to obtain a solution A;
(II) stirring hydrolyzed chitin and water at 25 ℃ at 180rpm until the hydrolyzed chitin and the water are uniformly dispersed, heating to 80 ℃, adding acrylic acid (ester)/acrylamide copolymer, stirring at 280rpm for 5.5 hours, cooling to 25 ℃, adding hydrolyzed corn starch, and stirring at 180rpm for 1.5 hours to obtain a solution B;
(III) stirring the solution A obtained in the step (I) and the solution B obtained in the step (II) at 250rpm for 1.5h, adding the zanthoxylum bungeanum maxim extract, and continuously stirring for 50min to obtain the high-safety anti-dandruff composition.
The hair care product comprises the components shown in the table 4, and the preparation method comprises the following steps:
s1, stirring the phase A uniformly, mixing the phase A with the phase B, heating the phase A to 65 ℃, adding the phase D and the phase E, heating the phase D to 82 ℃, preserving heat for 12min, and defoaming to obtain a mixture 1;
s2, stirring the phase F and the mixture 1 obtained in the step S1 at 82 ℃ until the phase F is completely and uniformly dissolved, preserving the temperature for 12min, and defoaming to obtain a mixture 2;
s3, cooling to 55 ℃, and fully and uniformly stirring the phase G and the mixture 2 obtained in the step S2 to obtain a mixture 3;
s4, cooling to 45 ℃, and fully and uniformly stirring the H phase and the mixture 3 obtained in the step S3 to obtain a mixture 4;
and S5, uniformly stirring the phase I and the mixture 4 obtained in the step S4, adding the phase J to adjust the pH of a 10% aqueous solution of the product to be 5.8, adding the phase K to adjust the viscosity, cooling to 34 ℃, defoaming and filtering to obtain the hair care product.
Table 4 hair care product component formulations of example 4
Example 5
This example provides a highly safe anti-dandruff composition and hair care product.
The high-safety anti-dandruff composition comprises the following components in parts by mass: 0.025 parts of quaternary ammonium salt, 20 parts of glycerol, 3.0 parts of polysorbate, 2.5 parts of hydrolyzed chitin, 58.275 parts of water, 6.0 parts of acrylic acid (ester)/acrylamide copolymer, 10 parts of hydrolyzed corn starch and 0.2 part of zanthoxylum bungeanum maxim extract.
The preparation method of the high-safety anti-dandruff composition comprises the following steps:
stirring quaternary ammonium salt-73, glycerol and polysorbate-20 at 90 ℃ and 2000rpm for 1h, and cooling to 72 ℃ to obtain a solution A;
(II) stirring hydrolyzed chitin and water at room temperature at 200rpm until the hydrolyzed chitin and the water are uniformly dispersed, heating to 85 ℃, adding acrylic acid (ester)/acrylamide copolymer, stirring at 250rpm for 6 hours, cooling to 25 ℃, adding hydrolyzed corn starch, and stirring at 200rpm for 2 hours to obtain a solution B;
(III) stirring the solution A obtained in the step (I) and the solution B obtained in the step (II) at 300rpm for 2 hours, adding the zanthoxylum bungeanum fruit extract, and continuously stirring for 1 hour to obtain the anti-dandruff composition.
The hair care product comprises the components shown in the table 5, and the preparation method comprises the following steps:
s1, stirring the phase A uniformly, mixing the phase A with the phase B, heating the phase A to 62 ℃, adding the phase D and the phase E, heating the phase D to 85 ℃, preserving the heat for 10min, and defoaming to obtain a mixture 1;
s2, stirring the phase F and the mixture 1 obtained in the step S1 at 80 ℃ until the phase F is completely and uniformly dissolved, preserving the temperature for 10min, and defoaming to obtain a mixture 2;
s3, cooling to 56 ℃, and fully and uniformly stirring the phase G and the mixture 2 obtained in the step S2 to obtain a mixture 3;
s4, cooling to 45 ℃, and fully and uniformly stirring the H phase and the mixture 3 obtained in the step S3 to obtain a mixture 4;
and S5, uniformly stirring the phase I and the mixture 4 obtained in the step S4, adding the phase J to adjust the pH of a 10% aqueous solution of the product to be =5.7, adding the phase K to adjust the viscosity, cooling to 28 ℃, defoaming and filtering to obtain the hair care product.
TABLE 5 Hair Care product Components formula of example 5
Example 6
This example provides a high safety anti-dandruff composition and hair care product.
The high-safety anti-dandruff composition comprises the following components in parts by mass: 0.022 part of quaternary ammonium salt-73.022 parts, 18 parts of glycerol, 1.5 parts of polysorbate-20, 4.0 parts of hydrolyzed chitin, 63.858 parts of water, 3.5 parts of acrylic acid (ester)/acrylamide copolymer, 9.0 parts of hydrolyzed corn starch and 0.12 part of zanthoxylum bungeanum maxim extract.
The preparation method of the high-safety anti-dandruff composition comprises the following steps:
stirring quaternary ammonium salt-73, glycerol and polysorbate-20 at 87 ℃ and 1800rpm for 50min, and cooling to 70 ℃ to obtain a solution A;
(II) stirring hydrolyzed chitin and water at the temperature of 25 ℃ at 160rpm until the hydrolyzed chitin and the water are uniformly dispersed, heating to 82 ℃, adding acrylic acid (ester)/acrylamide copolymer, stirring for 5 hours at the speed of 300rpm, cooling to 25 ℃, adding hydrolyzed corn starch, and stirring for 1.5 hours at the speed of 160rpm to obtain a solution B;
(III) stirring the solution A obtained in the step (I) and the solution B obtained in the step (II) at 200rpm for 1.5h, adding the zanthoxylum bungeanum maxim extract, and continuously stirring for 40min to obtain the high-safety anti-dandruff composition.
A hair care product, the components of which are shown in Table 6, is prepared by a method comprising the following steps:
s1, stirring the phase A to be uniform, mixing the phase A with the phase B, stirring the phase A to be uniform, mixing the phase A with the phase C, heating the mixture to 60 ℃, adding the phase D and the phase E, heating the mixture to 84 ℃, preserving heat for 10min, and defoaming to obtain a mixture 1;
s2, stirring the phase F and the mixture 1 obtained in the step S1 at 84 ℃ until the phases are completely and uniformly dissolved, preserving the temperature for 10min, and defoaming to obtain a mixture 2;
s3, cooling to 60 ℃, and fully and uniformly stirring the phase G and the mixture 2 obtained in the step S2 to obtain a mixture 3;
s4, cooling to 45 ℃, and fully and uniformly stirring the H phase and the mixture 3 obtained in the step S3 to obtain a mixture 4;
and S5, uniformly stirring the phase I and the mixture 4 obtained in the step S4, adding the phase J to adjust the pH of a 10% aqueous solution of the product to be =5.9, adding the phase K to adjust the viscosity, cooling to 40 ℃, defoaming and filtering to obtain the hair care product.
TABLE 6 formulation of the hair care product components of example 6
Comparative examples 1 to 8
Comparative examples 1 to 8 provide a high-safety anti-dandruff composition and a hair care product, respectively.
The high-safety anti-dandruff composition has the following formula shown in Table 7, and is prepared by the same method as in example 1.
The hair care product was substantially the same as in example 1, except that the high-safety anti-dandruff composition obtained in the comparative example was used, and the preparation method was the same as in example 1.
Table 7 formulation of high safety anti-dandruff compositions for comparative examples 1 to 8/in parts by mass
Comparative examples 9 to 13
Comparative examples 9 to 13 provide a highly safe anti-dandruff composition and hair care product, respectively.
The preparation method of the high-safety anti-dandruff composition is the same as that of example 1, and the formula is basically the same as that of example 1, except that:
comparative example 9 Stachys sieboldii extract was used instead of Zanthoxylum bungeanum fruit extract;
comparative example 10 employed a hydrolyzed chitin deacetylation degree of less than 40%;
comparative example 11 using a hydrolyzed chitin deacetylation degree greater than 90%;
comparative example 12 hydrolyzed wheat starch was used instead of hydrolyzed corn starch;
comparative example 13 salicylic acid was used instead of quaternary ammonium salt-73.
The hair care product was substantially the same as in example 1 except that the high-safety anti-dandruff composition obtained in the comparative example was used and the same procedure as in example 1 was used.
Comparative examples 14 to 15
Comparative examples 14 to 15 each provide a hair care product prepared in the same manner as in example 1 and having substantially the same formulation as in example 1, except that:
comparative example 14 using water instead of the high safety anti-dandruff composition;
comparative example 15 employs 0.3% piroctone olamine salt (OCT) instead of the high safety anti-dandruff composition.
Effect example 1 eye irritation test
The high-safety anti-dandruff compositions of examples 1 to 3 and comparative examples 1 to 13 and 0.1% piroctone Olamine (OCT) solution were subjected to eye irritation test according to SN/T2329-2009 "chick embryo chorioallantoic membrane test for cosmetic eye irritation corrosivity", respectively, and the results were evaluated by the irritation grading method, and the test results are shown in table 8.
The adopted chicken embryo is BWEL-SPF chicken of emerging Dahua agricultural egg Limited company, the chicken is 0 day old and qualified according to GB/T17999.1-2008.
Before the test, the high-safety anti-dandruff compositions of examples 1 to 3 and comparative examples 1 to 13 are respectively prepared into 3 percent aqueous solution for standby; OCT was formulated as 0.1% OCT solution with polysorbate-20 and 1, 3-butanediol for future use.
TABLE 8 irritation test results of the high-safety anti-dandruff compositions of examples 1 to 3 and comparative examples 1 to 13
From the results of the eye irritation test of Table 8, it can be seen that the high-safety anti-dandruff compositions of examples 1 to 3 are non-irritating and less irritating than the high-safety anti-dandruff compositions of comparative examples 3, 6, 8 and 0.1% OCT solution. The traditional anti-dandruff agent OCT belongs to a strong irritant raw material and inevitably has an irritation effect on skin or scalp, while the high-safety anti-dandruff composition disclosed by the invention is low in irritation, and the safety of the high-safety anti-dandruff composition is greatly improved compared with that of the traditional anti-dandruff agent.
Effect example 2 synergistically reduced irritation test
The high-safety anti-dandruff compositions of examples 1 to 3 and comparative examples 1 to 13 were subjected to zein method for measuring irritability, and the zein value of each high-safety anti-dandruff composition was measured by this method, and the measurement results are shown in table 9. When the zein value is larger than N4 g/L, the surfactant is strong in irritation; a surfactant with a zein value of 2-4g/L is "low irritancy"; surfactants with zein values less than N2 g/L are "non-irritating". Assay methods references: dongyin Mao, sxiao Sai, penjin the irritability of surfactants was tested with zein [ J ]. Daily chemical industry, 2002,32 (5): 59-61.
The high-safety anti-dandruff compositions of examples 1 to 3 and comparative examples 1 to 13 were respectively prepared as 1.5% aqueous solutions before the test.
TABLE 9 zein test results of the high safety anti-dandruff compositions of examples 1-3 and comparative examples 1-13
| Group of | zein value | Irritation classification |
| Example 1 | 0.5 | Has no irritation |
| Example 2 | 0.3 | Has no irritation |
| Example 3 | 0.2 | Has no irritation |
| Comparative example 1 | 1.3 | Has no irritation |
| Comparative example 2 | 1.2 | Has no irritation |
| Comparative example 3 | 2.3 | Low irritation |
| Comparative example 4 | 0.8 | Has no irritation |
| Comparative example 5 | 1.0 | Has no irritation |
| Comparative example 6 | 4.3 | Strong irritation |
| Comparative example 7 | 0.8 | Has no irritation |
| Comparative example 8 | 4.1 | Strong irritation |
| Comparative example 9 | 1.2 | Has no irritation |
| Comparative example 10 | 1.1 | Has no irritation |
| Comparative example 11 | 0.9 | Has no irritation |
| Comparative example 12 | 0.4 | Has no irritation |
| Comparative example 13 | 0.6 | Has no irritation |
Investigation of the ability of high safety anti-dandruff compositions to synergistically reduce irritation: the zein values of the 1.5% high safety anti-dandruff composition solution in 0.3% SDS aqueous solution were examined using 0.3% SDS aqueous solution as a control, and the results are shown in Table 10.
TABLE 10 results of the antidandruff composition synergy irritation reduction test of examples 1 to 3 and comparative examples 1 to 13
| Group of | zein value | Irritation classification |
| 0.3％SDS | 5.6 | Strong irritation |
| 0.3% SDS + example 1 | 1.5 | Has no irritation |
| 0.3% SDS + example 2 | 1.8 | Has no irritation |
| 0.3% SDS + example 3 | 1.6 | Has no irritation |
| 0.3% SDS + comparative example 1 | 4.4 | Strong irritation |
| 0.3% SDS + comparative example 2 | 3.7 | Strong irritation |
| 0.3% SDS + comparative example 3 | 4.5 | Strong irritation |
| 0.3% SDS + comparative example 4 | 3.5 | Low irritation |
| 0.3% SDS + comparative example 5 | 3.3 | Low irritation |
| 0.3% SDS + comparative example 6 | 6.3 | Strong irritation |
| 0.3% SDS + comparative example 7 | 5.3 | Strong irritation |
| 0.3% SDS + comparative example 8 | 7.6 | Strong irritation property |
| 0.3% SDS + comparative example 9 | 3.5 | Low irritation |
| 0.3% SDS + comparative example 10 | 2.5 | Low irritation |
| 0.3% SDS + comparative example 11 | 2.3 | Low irritation |
| 0.3% SDS + comparative example 12 | 3.2 | Low irritation |
| 0.3% SDS + comparative example 13 | 3.1 | Low irritation |
As can be seen from the results of the zein test of tables 9 and 10, the high-safety anti-dandruff compositions of examples 1 to 3 of the present invention were less irritating than the high-safety anti-dandruff compositions of comparative examples 1 to 13, and the irritativeness was significantly reduced by mixing with 0.3% SDS. It was thus judged that the highly safe anti-dandruff composition of the present invention can reduce the irritation of the whole formulation among hair care products. In addition, as can be seen from the test results, the high-safety anti-dandruff compositions 1 to 3 of the embodiments of the present invention can significantly reduce the SDS irritation, while the compositions 1 to 9 have a poor effect of reducing the SDS irritation, which indicates that in the present invention, there is a synergistic effect of the hydrolyzed chitin, the quaternary ammonium salt-73, the hydrolyzed corn starch and the zanthoxylum bungeanum fruit extract, and the irritation of SDS can be significantly reduced when the four are used together; it is understood from the results of comparative examples 1 to 3 and comparative examples 10 to 13 that although the highly safe antidandruff composition using hydrolyzed chitin with a deacetylation degree of less than 40% or more than 90% and hydrolyzed wheat starch instead of hydrolyzed corn starch is non-irritating, the irritation thereof cannot be effectively reduced when it is compounded with a strongly irritating surfactant, and thus the irritation can be further reduced by using a composition compounded with hydrolyzed chitin, hydrolyzed corn starch, and quaternary ammonium salt-73 with a deacetylation degree of 40% to 90%, and thus the compounding effect of the hydrolyzed chitin, hydrolyzed corn starch, and quaternary ammonium salt-73 with a deacetylation degree of 40% to 90% is more preferable in the present invention.
Effect example 3 Malassezia inhibition test
Malassezia inhibition was measured using the high-safety anti-dandruff compositions of examples 1 to 3 and comparative examples 1 to 13, the hair care products of examples 1 to 3, zinc Pyrithione (ZPT) solution, and piroctone Olamine (OCT) solution according to QBT2738-2012 (7.3), evaluation method for antibacterial and bacteriostatic effects of daily chemical products, and the results of Malassezia inhibition test for the high-safety anti-dandruff compositions, ZPT, and OCT are shown in Table 11 and the results of hair care products are shown in Table 12, respectively.
Before the test, the high-safety anti-dandruff compositions of examples 1 to 3 and comparative examples 1 to 13 were respectively prepared as 1% aqueous solutions; ZPT is prepared into 0.5 percent aqueous dispersion; OCT is prepared by polysorbate-20 and 1, 3-butanediol to be 0.3% solution; examples 1-3 hair care products were each formulated as a 10% aqueous solution.
TABLE 11 inhibition rates of Malassezia, a high-safety anti-dandruff composition for examples 1 to 3 and comparative examples 1 to 13
TABLE 12 inhibition ratio of malassezia as hair care product of examples 1 to 3
| Group of | Rate of inhibition of bacteria |
| Example 1 | 99.5 |
| Example 2 | 99.3 |
| Example 3 | 99.5 |
According to the results of the bacteriostatic rate tests in table 11, the high-safety anti-dandruff compositions of examples 1 to 3 of the present invention have a good ability to inhibit malassezia bacteria, and the inhibitory effects are equivalent to those of the conventional anti-dandruff agents Zinc Pyrithione (ZPT) and piroctone Olamine (OCT), which indicate that both the high-safety anti-dandruff compositions of the present invention and the conventional anti-dandruff agents can achieve the anti-dandruff effect by inhibiting malassezia bacteria. The high-safety anti-dandruff compositions of examples 1 to 3 have stronger ability to inhibit malassezia than the high-safety anti-dandruff compositions of comparative examples 1 to 9, which shows that the hydrolyzed chitin, the quaternary ammonium salt-73, the hydrolyzed corn starch and the zanthoxylum fruit extract directly have synergistic effect, and the four have the strongest ability to inhibit the malassezia when used together. Comparing the results of the high-safety anti-dandruff compositions of examples 1 to 3 and the high-safety anti-dandruff compositions of comparative examples 10 to 13, it can be seen that the effect of inhibiting malassezia by using the composition compounded by the hydrolyzed chitin, the hydrolyzed corn starch and the quaternary ammonium salt-73, the deacetylation degree of which is 40 to 90 percent, is better. As can be seen from the test results in table 12, the hair care product using the high-safety anti-dandruff composition of the present invention as an anti-dandruff agent has a superior inhibitory effect on malassezia.
Effect example 4 dandruff removal efficacy test
The using method of the hair care product comprises the following steps: a 2-week washout period was set before testing to avoid the effects of the original product deposition on the hair, scalp. Based on the consistency of the eluted products, the experiment adopts a no/very weak conditioning and strong baby washing two-in-one as an eluent, and the eluent is used once every 2 days or 3 days. After the 2 weeks of the wash-off period, the volunteer used the hair care product or contrast care product by oneself, and at least one unitary coin size of amount of use at every turn can be used by oneself according to hair amount and length, uses 1 time every 2 days. Visits were made, filling out questionnaires and testing the head area, both at the beginning of use and after 4 weeks of use. Each group of volunteers had 20 persons.
The volunteers were 19-50 years old, had oily scalp with much dandruff and were not stained 3 months before the test.
And (3) determining the anti-dandruff efficacy: photographs of the positions of the tops of the volunteers' heads were taken using a PhotoMax aurora lens, and it was observed whether or not the dandruff condition of the volunteers was improved using the hair care products of examples 1 to 3 and comparative examples 1 to 15, and the results are shown in table 13.
Dandruff evaluation method: selecting 4 most severe regions from 12 regions according to the schematic diagram of the assessment region, and assessing the dandruff index of each region by 2-3 times, and taking the average value, wherein the score standard of the dandruff index is shown in figure 1, and the schematic diagram of the assessment region is shown in figure 2. The anti-dandruff effect is represented by a dandruff index improvement value, wherein the improvement value = (post-use dandruff index score-pre-use dandruff index score)/pre-use dandruff index score x 100%, and the higher the improvement value is, the more remarkable the anti-dandruff effect of the hair care product is.
TABLE 13 evaluation of antidandruff Effect of Hair Care products of examples 1 to 3 and comparative examples 1 to 15
| Item | Improvement after 4 weeks of use |
| Example 1 | 36％ |
| Example 2 | 32％ |
| Example 3 | 33％ |
| Comparative example 1 | 5％ |
| Comparative example 2 | 8％ |
| Comparative example 3 | 19％ |
| Comparative example 4 | 20％ |
| Comparative example 5 | 15％ |
| Comparative example 6 | 12％ |
| Comparative example 7 | 3％ |
| Comparative example 8 | 6％ |
| Comparative example 9 | 20％ |
| Comparative example 10 | 25％ |
| Comparative example 11 | 27％ |
| Comparative example 12 | 20％ |
| Comparative example 13 | 8％ |
| Comparative example 14 | 1％ |
| Comparative example 15 | 18％ |
The results in Table 14 show that the hair care products of examples 1 to 3 according to the invention have a superior anti-dandruff effect than the comparative care product of the comparative example. The anti-dandruff effect of the hair care products of examples 1 to 3 of the present invention is superior to that of the comparative care product 13, which shows that the anti-dandruff effect of the hair care product of the present invention is superior to that of the hair care product added with common anti-dandruff agent piroctone Olamine (OCT) on the market.
Effect example 5 oil control efficacy measurement
The application method, the volunteer requirements, and the pre-treatment for measuring the indexes of the hair care product in the effect example are the same as those in effect example 4.
The scalp oil content of the hair care products of examples 1 to 3 and comparative examples 1 to 15 was measured by the Sebumeter method, the position of the test was the vertex, the scalp oil content was measured at a specific position on the vertex as shown in fig. 3, each point was measured 3 times, the average value was taken, the oil control effect was exhibited at the scalp oil change rate, and the results are shown in table 14. Scalp fat change rate = (scalp fat content before use-scalp fat content after use)/scalp fat content before use × 100%.
TABLE 14 determination of oil control Effect of Hair Care products of examples 1 to 3 and comparative examples 1 to 15
The test results in table 14 show that the hair care products of examples 1 to 3 of the present invention have better oil control effects than the comparative care products of comparative examples 1 to 15, indicating that the high-safety anti-dandruff composition of the present invention has good oil control effects and the oil control effects are better than the common anti-dandruff agent piroctone Olamine (OCT) on the market.
The hair care products of examples 1-3 had better oil control than the hair care products of comparative examples 1-9, 12, and 13, indicating that there was a synergistic effect between hydrolyzed chitin, quaternary ammonium salt-73, hydrolyzed corn starch, and zanthoxylum fruit extract, and the high-safety anti-dandruff composition consisting of the four had a good effect of controlling oil of the scalp when applied to the hair care products. The scalp oil-controlling effects of the hair care products of examples 1 to 3 are superior to those of the hair care products of comparative examples 10 and 11, which shows that the oil-controlling effects of the high-safety anti-dandruff composition can be better exerted by selecting hydrolyzed chitin having a deacetylation degree of 40% to 90% when preparing the high-safety anti-dandruff composition of the present invention.
Effect example 6 satisfaction degree survey
The satisfaction of the volunteers to the effects of the hair care products of examples 1 to 3 and comparative examples 1 to 15 was evaluated by means of questionnaire investigation, the questionnaire consisted of items of anti-dandruff effect, oil control effect, cleansing effect, wet combing effect, dry combing effect and fluffy effect, the satisfaction of each item was counted, the statistical results are shown in table 15, and the method of using the hair care products by the volunteers was the same as that of effect example 4.
TABLE 15 hair care product satisfaction ratios of examples 1-3 and comparative examples 1-15
As can be seen from the data in table 15, the satisfaction ratios of the volunteers with the anti-dandruff effect, the oil-controlling effect and the cleansing effect of the hair care products of examples 1 to 3 of the present invention were all superior to those of the hair care products of the comparative example. The hair care products of examples 1-3 of the present invention were superior in satisfaction ratio to the hair care product of comparative example 15, indicating that the volunteers experienced better anti-dandruff, oil control and cleansing effects than the commercial hair care products containing the conventional anti-dandruff agent piroctone Olamine (OCT).
The above-mentioned embodiments are provided to further explain the objects, technical solutions and advantages of the present invention in detail, and it should be understood that the above-mentioned embodiments are only examples of the present invention and are not intended to limit the scope of the present invention. It should be understood that various changes, substitutions and alterations can be made herein without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (10)
1. The high-safety anti-dandruff composition is characterized by comprising the following components in parts by mass: 2.0-5.0 parts of hydrolyzed chitin, 6.0-10 parts of hydrolyzed corn starch, 0.015-0.025 part of quaternary ammonium salt, 0.1-0.2 part of pepper fruit extract and water until the total mass part is 100 parts.
2. The high-safety anti-dandruff composition according to claim 1, which comprises the following components in parts by mass: 3.2 parts of hydrolyzed chitin, 8.0 parts of hydrolyzed corn starch, 0.02 part of quaternary ammonium salt-73.02 parts, 0.15 part of pepper fruit extract and water until the total mass part is 100 parts.
3. A high safety anti-dandruff composition according to claim 1, comprising at least one of:
the high-safety anti-dandruff composition also comprises the following components in parts by mass: 15-20 parts of glycerol, 3.0-6.0 parts of acrylic acid (acrylate)/acrylamide copolymer and 1.0-3.0 parts of polysorbate-20;
the acrylic acid (ester)/acrylamide copolymer is binary copolymer of acrylic ester and acrylamide, and has molecular weight of (60-100) x 10 3 g/mol；
The hydrolyzed chitin is chitin enzymolysis product, the deacetylation degree is 40-90%, and the viscosity average molecular weight is (0.85-2.64) × 10 4 g/mol；
The quaternary ammonium salt-73 has a molecular structure of
4. A method for preparing a high-safety anti-dandruff composition according to any one of claims 1 to 3, comprising the steps of:
A. mixing the hydrolyzed chitin with water, adding hydrolyzed corn starch, and mixing to obtain solution 1;
B. and B, mixing the quaternary ammonium salt-73 with the solution 1 in the step A, adding the zanthoxylum fruit extract, and mixing to obtain the anti-dandruff composition.
5. The method for preparing a high-safety anti-dandruff composition according to claim 4, comprising at least one of:
mixing the hydrolyzed chitin and water at 20-35 deg.C and 100-200rpm, and stirring to disperse uniformly;
adding the hydrolyzed corn starch and mixing for 0.5-2h at 100-200 rpm;
b, mixing the quaternary ammonium salt-73 and the solution 1 for stirring for 0.5-2h at 150-300 rpm;
and B, adding the zanthoxylum bungeanum maxim extract, and mixing for 0.5-1h at 150-300 rpm.
6. The method for preparing a high-safety anti-dandruff composition according to claim 4 or 5, wherein when the high-safety anti-dandruff composition further comprises glycerol, polysorbate-20 and acrylic acid/acrylamide copolymer, the method comprises the following steps:
a. mixing hydrolyzed chitin and water, heating, adding acrylic acid (ester)/acrylamide copolymer, mixing, cooling, adding hydrolyzed corn starch, and mixing to obtain solution 1;
b. heating and mixing quaternary ammonium salt-73, glycerol and polysorbate-20 in advance, cooling, mixing with the solution 1 obtained in the step a, adding a zanthoxylum fruit extract, and mixing to obtain an anti-dandruff composition;
the heating in the step a is heating to 75-85 ℃;
step a, adding acrylic acid (ester)/acrylamide copolymer for mixing, and stirring at 150-300rpm for 4-6h;
the temperature reduction of the step a is to reduce the temperature to 65-75 ℃;
the heating and mixing of the step b is stirring for 0.5 to 1 hour at the temperature of between 85 and 90 ℃ and at the rpm of between 1000 and 2000;
and in the step b, the temperature is reduced to 65-75 ℃.
7. Use of a high-safety antidandruff composition according to any one of claims 1 to 3 for the preparation of a hair care product.
8. The hair care product is characterized by comprising the following components in parts by mass:
phase A, which comprises 0.03 to 0.07 part of polyethylene glycol-7M and water, and is complemented until the total mass part of each phase is 100 parts;
phase B, including polyquaternium-10.05-0.15 parts;
phase C, including guar gum hydroxypropyl trimethyl ammonium chloride 0.2-0.4 parts;
phase D, including EDTA disodium 0.05-0.15 parts, citric acid 0.1-0.2 parts;
phase E, including sodium citrate 0.2-0.4;
phase F, including 8-13 parts of sodium laureth sulfate, 2-4 parts of ammonium laureth sulfate, 0.5-1.5 parts of cocoyl MEA, 0.8-1.5 parts of ethylene glycol distearate and 3-7 parts of amino acid surfactant;
the G phase comprises 0.5-1.5 parts of amphoteric surfactant and 0.2-0.4 part of maleic acid modified castor oil;
a phase H comprising 1 to 3 parts of the high-safety anti-dandruff composition according to claim 1, and 3 to 5 parts of water;
phase I comprising polydimethylsiloxane/water/laureth-23/C 12-15 1.3-2 parts of alkanol polyether-3/phenoxyethanol/ethylhexyl glycerin, 0.3-0.5 part of sodium benzoate, 0.2-0.4 part of phenoxyethanol, 0.05-0.2 part of dichlorobenzyl alcohol/butanediol/cocamidopropyl PG-dimethyl ammonium chloride phosphate sodium, 1-3 parts of daily essence, 0.1-0.3 part of secondary cracking yeast fermentation product filtrate, and 0.005-0.015 part of water/butanediol/glycerin/sodium lactate/serine/glycine/alanine/arginine/aspartic acid/valine/leucine/glutamic acid/potassium hydroxide/proline/citric acid;
phase J, including citric acid 0.1-0.3 parts;
and the K phase comprises 0.2-0.5 part of sodium chloride.
9. The hair care product of claim 8, comprising at least one of:
the amino acid surfactant in phase F is a mixture of 1-3 parts water/sodium methyl cocoyl taurate/sodium chloride and 2-4 parts water/potassium cocoyl hydrolyzed oat protein/potassium chloride;
the amphoteric surfactant in phase G is water/sodium cocoamidopropyl PG-dimethyl ammonium chloride phosphate/sodium chloride.
10. A process for the preparation of a hair care product as claimed in any one of claims 8 or 9, comprising the steps of:
mixing the S1 phase, the A phase, the B phase and the C phase, heating, adding the D phase and the E phase, heating, preserving heat and defoaming to obtain a mixture 1;
s2, mixing the phase F with the mixture 1 obtained in the step S1, preserving heat, and defoaming to obtain a mixture 2;
s3, cooling, and mixing the phase G with the mixture 2 obtained in the step S2 to obtain a mixture 3;
s4, cooling, and mixing the H phase with the mixture 3 obtained in the step S3 to obtain a mixture 4;
s5, mixing the phase I with the mixture 4 obtained in the step S4, adding the phase J to adjust the pH value, adding the phase K to adjust the viscosity, cooling, defoaming and filtering to obtain a hair care product;
in the step S1, mixing the phase A, the phase B and the phase C, namely, mixing the materials of the phase A uniformly, adding the phase B, mixing uniformly, adding the phase C, and dispersing uniformly;
in the step S1, the heating temperature is 60-65 ℃, the temperature is increased to 80-85 ℃, and the heat preservation time is 10-15min;
in the step S2, the mixing is carried out at the temperature of 80-85 ℃, and the heat preservation time is 10-15min;
in the step S3, the temperature is reduced to 55-60 ℃;
in the step S4, the temperature is reduced to 20-45 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211373579.7A CN115581650B (en) | 2022-11-03 | 2022-11-03 | High-safety anti-dandruff composition and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211373579.7A CN115581650B (en) | 2022-11-03 | 2022-11-03 | High-safety anti-dandruff composition and preparation method and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN115581650A true CN115581650A (en) | 2023-01-10 |
| CN115581650B CN115581650B (en) | 2023-05-23 |
Family
ID=84782508
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211373579.7A Active CN115581650B (en) | 2022-11-03 | 2022-11-03 | High-safety anti-dandruff composition and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115581650B (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111265439A (en) * | 2020-02-11 | 2020-06-12 | 歆芳生物科技(广州)有限公司 | Oil-control, dandruff-removing and itching-relieving shampoo and preparation method thereof |
| CN114533586A (en) * | 2021-11-23 | 2022-05-27 | 广州市科能化妆品科研有限公司 | Dandruff-removing itching-relieving shampoo composition, and preparation method and application thereof |
-
2022
- 2022-11-03 CN CN202211373579.7A patent/CN115581650B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111265439A (en) * | 2020-02-11 | 2020-06-12 | 歆芳生物科技(广州)有限公司 | Oil-control, dandruff-removing and itching-relieving shampoo and preparation method thereof |
| CN114533586A (en) * | 2021-11-23 | 2022-05-27 | 广州市科能化妆品科研有限公司 | Dandruff-removing itching-relieving shampoo composition, and preparation method and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN115581650B (en) | 2023-05-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101214201B (en) | Nourishing anti-dandruff shampoo composition | |
| CN104000749B (en) | A kind of scalp nursing solution | |
| CN107349122A (en) | A kind of desquamation compositions and its application | |
| CN101966131B (en) | Antimicrobial and antidandruff composition and application thereof | |
| CN102716045B (en) | Shampoo composition containing double anti-dandruff agents | |
| CN108186385A (en) | A kind of hair scalp cleaning compositions | |
| CN107875064A (en) | A kind of scalp care compositions | |
| CN110123721B (en) | Shampoo composition for improving oily scalp | |
| CN113332191A (en) | Shampoo and preparation method thereof | |
| CN107308014A (en) | One kind thickening suspension composition and its application | |
| CN108992357A (en) | A kind of anti-dandruff and itching-relieving shampoo containing silk hydroiyzing liquid | |
| CN111888271B (en) | Powder-based liquid-based composite shampoo and preparation method and application method thereof | |
| CN112891252A (en) | Mild itching-relieving bath composition and preparation method thereof | |
| CN115581650B (en) | High-safety anti-dandruff composition and preparation method and application thereof | |
| CN112999138A (en) | Plant dandruff-removing and itching-relieving composition, plant dandruff-removing and itching-relieving shampoo and preparation method thereof | |
| CN101129299B (en) | Anti-dandruff composition and use thereof | |
| CN115634172B (en) | Scalp microecological stabilizer and preparation method and application thereof | |
| CN114306197A (en) | Bubble hair conditioner | |
| CN109602664B (en) | Dandruff-removing nourishing shampoo | |
| CN112006954A (en) | Shampoo and preparation method thereof | |
| CN110090168A (en) | It is a kind of have effects that hair growing wash shield product | |
| CN110101609A (en) | A kind of mild no silicone oil shampoo used also as bath lotion and preparation method thereof containing camellia seed oil | |
| CN110279595A (en) | A kind of submissive shampoo of no silicone oil | |
| CN109908061A (en) | A kind of fizzy dandruff control shampoo containing and preparation method thereof | |
| CN114917135B (en) | Shampoo taking salicylic acid and sulfur as basic materials and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |