CN115561164A - Solid phase method detector and detection method - Google Patents

Solid phase method detector and detection method Download PDF

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Publication number
CN115561164A
CN115561164A CN202210992523.3A CN202210992523A CN115561164A CN 115561164 A CN115561164 A CN 115561164A CN 202210992523 A CN202210992523 A CN 202210992523A CN 115561164 A CN115561164 A CN 115561164A
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card
reagent
platform
sample adding
reagent card
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刘鹏
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Maide Shandong Technology Co ltd
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Maide Shandong Technology Co ltd
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Priority to CN202210992523.3A priority Critical patent/CN115561164A/en
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00732—Identification of carriers, materials or components in automatic analysers

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  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

The invention relates to the field of biological experiments, in particular to a solid-phase method detector and a detection method, which comprises a shell, wherein a sample adding mechanism and a sample adding platform are arranged in the shell, the sample adding mechanism is arranged above the sample adding platform, and a card bin for providing and recovering a reagent card is arranged on one side of the shell; and the card cabin is communicated with the shell; the sample adding mechanism is used for transferring the reagent card from the card bin to the sample adding platform or transferring the reagent card from the sample adding platform to the card bin, so that the liquid transferring work of the sample to the dry chemical reagent card is completed; the sample adding platform is used for placing test tubes and reagent cards. The invention can complete the recording of relevant data in the solid phase method experiment process, and the result can be traced; the workload of operators is reduced.

Description

Solid phase method detector and detection method
Technical Field
The invention relates to the field of biological experiments, in particular to a solid-phase method detector and a detection method.
Background
The solid phase method, also called solid phase chemical method or dry chemical method, is a solid phase reagent technique using a multilayer thin film. The liquid sample is directly added into a reagent carrier solidified in a special structure, namely a dry chemical reagent, water in the sample is used as a solvent, the reagent solidified on the carrier is dissolved, and then the reagent and components to be detected in the sample are subjected to chemical reaction, so that analysis and determination are carried out, and finally the concentration or activity of an object to be detected is obtained.
At present, solid phase method tests are mainly performed in a manual operation mode in hospitals or physical examination centers, the automation degree is low, the experimental process is not controlled, the experimental result is difficult to trace, and the standardization degree is low.
Disclosure of Invention
The invention provides a solid phase method detector and a detection method aiming at the problems, the invention can complete the recording of relevant data in the solid phase method experiment process, and the result can be traced; the workload of operators is reduced.
The invention provides the following technical scheme: a solid phase method detector comprises a shell, wherein a sample adding mechanism and a sample adding platform are arranged in the shell, the sample adding mechanism is arranged above the sample adding platform, and a card bin for providing and recovering a reagent card is arranged on one side of the shell; and the card bin is communicated with the shell.
The sample adding mechanism is used for transferring the reagent card from the card bin to the sample adding platform or transferring the reagent card from the sample adding platform to the card bin, so that the liquid transferring work of the sample to the dry chemical reagent card is completed; the sample adding platform is used for placing test tubes and reagent cards and can be used for placing reagents and the like.
The card storehouse include reagent card rack, set up in reagent card rack below and push away card mechanism, push away the exit of card mechanism and set up reagent card transport mechanism, reagent card transport mechanism stretch into application of sample platform top. Push away card mechanism and push away reagent card transport mechanism department, transport mechanism transports the shell with the reagent card in, the application of sample mechanism of being convenient for transports like this, transport mechanism can the both-way operation, and the back is accomplished in the experiment, and application of sample mechanism transports the transport mechanism with the reagent card after the experiment, and transport mechanism transports the reagent card after the experiment out again, sets up the photoelectric sensing ware that is used for counting the reagent card and is used for surveying the humidity sensor who detects humidity in the card storehouse in calorie storehouse.
The reagent card placing frame and the card pushing mechanism are fixed with the card bin front cover, the card bin front cover is connected with the card bin shell through a card bin sliding rail, and a first electromagnet for adsorbing the card bin shell is arranged at the top of the card bin front cover. The sliding rail for the clamping bin is arranged, so that the drawer type structure is formed by the front cover and the shell, reagent cards can be conveniently placed in the drawer type structure, the front cover and the clamping bin are fixed through the electromagnet, and the situation that the front cover is pulled out in the using process of the detector and the experiment is influenced is avoided.
Abandon the bayonet socket in the one side setting of card storehouse keeping away from the shell, abandon the bayonet socket and correspond with reagent card transport mechanism, after the experiment, transport mechanism transports the reagent card after the experiment to transport mechanism, transport mechanism is to abandoning the bayonet socket with reagent card treehole, the staff can be setting up the collection basket at abandoning the bayonet socket and collect the reagent card after the experiment.
A code scanning device for identifying the two-dimensional code of the reagent card is arranged above the reagent card transferring mechanism, and a positioning device for positioning the reagent card is arranged on one side, close to the sample adding platform, of the reagent card transferring mechanism. Can realize like this to the record of reagent card, after the experiment, the reagent card is put back conveying platform by the tongs, later, sweeps a yard device and discerns once more and take notes the two-dimensional code on the reagent card, simultaneously, interprets the result to the reagent card after the colour rendering to by equipment host computer with bar code content record in experimental data, sweep a yard device and can adopt the camera.
According to the scheme, the card bin is of a drawer structure, the card bin can be pulled out to store and load reagent cards, the top of a front cover of the card bin can be fastened with the rack through an electromagnetic lock, the bottom of the front cover of the card bin is connected with the rack through two three-folded sliding rails, the reagent card placing position can store the reagent cards required by one-time experiments, and the card pushing structure at the bottom of the placing position can push the reagent cards at the bottom of the reagent card placing position to the reagent card transferring mechanism in the experiment process; the reagent card transferring mechanism comprises a synchronous belt conveying structure and a positioning device, the synchronous belt conveying structure can rotate left and right, after the card bin card pushing mechanism pushes the reagent card to the transferring platform, the conveying structure conveys the reagent card to the left, namely the inner direction of the equipment, after the reagent card is conveyed to a specified position, the positioning device positions the reagent card, and then the reagent card is transferred to the sample adding platform by a hand grip in the sample adding structure for experiment; after the experiment is finished, the reagent card is grabbed back to the reagent card transferring mechanism by the grabbing hand in the sample adding mechanism, and the reagent card transferring mechanism conveys the reagent card to the right and transfers the reagent card to a waste card collecting basket outside the device; the code scanning device can adopt a CCD camera, and before an experiment is started, after the reagent card is positioned by the positioning structure, the camera identifies and records the two-dimensional code on the reagent card; after the experiment is finished, the reagent card is placed back to the reagent card transferring mechanism by the gripper, then the camera identifies and records the two-dimensional code on the reagent card again, and meanwhile, the result of the developed reagent card is interpreted.
The sample adding platform comprises a drawer-type base, the base is connected with the shell through a platform slide rail, an inner rotating platform, an outer rotating platform and a fixed platform are arranged on the base, a test tube is clamped by the outer edge of the outer rotating platform and is driven to rotate, the test tube is clamped on the periphery of the outer rotating platform, a barcode label on the test tube faces to the direction far away from the outer rotating platform, and a plurality of clamping positions for containing reagent cards are arranged on the inner rotating platform; set up on the fixed platform that district, reagent storehouse are placed to the disposable suction head of application of sample rifle, interior rotary platform sets up in the fixed platform outside, and the rotary platform outside including outer rotary platform sets up. The inner rotary platform and the outer rotary platform are both annular, and the fixed platform is circular; the inner rotating platform and the outer rotating platform can rotate in different directions, the central axes of the inner rotating platform and the outer rotating platform are overlapped, and the fixed platform does not rotate.
The direction that the base towards shell rear portion be provided with the opening, correspond the opening play in the shell and set up the bar code reader that is used for sweeping the sign indicating number to the bar code label of test tube, set up the second electro-magnet that is used for adsorbing unable adjustment base in the shell. In the experimental process, a reagent or a sample loaded in a test tube is placed on a sample loading platform, the sample loading position of the test tube is fixed, and the test tube is transferred to the sample loading position through the rotation of an outer rotating platform; the internal rotation platform of application of sample platform drives the reagent card rotation: the reagent card is transferred to the position from the card bin, the transfer position of the reagent card is fixed, and the sample adding platform can transfer the reagent card to be transferred to the transfer position through rotation; the disposable suction head used by the sample adding gun is placed on the fixed platform, and in addition, a reagent bin is additionally placed on the fixed platform for other liquids in the experiment; before carrying out the application of sample to the liquid in the test tube, equipment can be earlier rotatory before the bar code ware to this test tube, by the bar code on the bar code ware scanning test tube to by the equipment host computer with the bar code content record in experimental data. Place the second electro-magnet on the shell at base rear, use the second electro-magnet to adsorb the application of sample platform in the shell in the experimentation, prevent that the application of sample platform from being pulled out by accident in the experimentation, wherein inside and outside rotary platform all adopts closed-loop control, set up the encoder on the step motor output shaft of driving inside and outside rotary platform promptly, the encoder is connected with the industrial control computer, industrial control computer control step motor work, the feedback of the acquisition step motor motion that can be timely like this, avoid losing the step and leading to the occurence of failure because of the step motor of driving inside and outside rotary platform.
The sample adding mechanism comprises an X-direction guide rail with a driving mechanism, a Y-direction guide rail and a Z-direction guide rail, the X-direction guide rail is fixed with the shell, the Y-direction guide rail is installed on a guide slider of the X-direction guide rail through a connecting piece, the Z-direction guide rail is installed on a guide slider of the Y-direction guide rail through a connecting piece, the sample adding gun is installed on a guide slider of the Z-direction guide rail through an adapter piece, and the transferring gripper is fixed on the Z-direction guide rail;
the X-direction guide rail is used for the sample adding gun and the transferring gripper to move in the X direction; the Y-direction guide rail is used for carrying out Y-direction movement on the sample adding gun and the transfer gripper; the Z-direction guide rail is used for the sample adding gun to move in the Z direction, and the transferring gripper is fixed with the Z-direction guide rail.
The transportation tongs including fixing the linear electric motor on Z direction guide rail, set up the sucking disc that is used for adsorbing the reagent card at linear electric motor's front end, set up the air supply that is used for providing the negative pressure for the sucking disc in the card storehouse, set up vacuum pressure switch on the pipeline that sucking disc and air supply are connected, whether the detectable produces the negative pressure, in time judge whether the reagent card drops.
A detection method of a solid phase method detector comprises the following steps:
s1, extracting the sample adding platform and the card bin mechanism, and respectively putting a sample, a reagent and a reagent card required by an experiment;
s2, pushing the reagent card to a reagent card transferring mechanism by a card pushing mechanism in the card bin structure, positioning the reagent card by the reagent card transferring mechanism and the positioning structure, identifying the two-dimensional code on the reagent card by a code scanning device in the card bin, recording the two-dimensional code in experimental data, and transferring the reagent card to a card position on a rotating platform of a sample adding platform by a transferring gripper of the sample adding mechanism;
s3, identifying a bar code of the test tube on the sample adding platform and recording the bar code in experimental data, then rotating the test tube and the reagent card to an appointed position by the sample adding platform, carrying out liquid absorption on samples/reagents in the test tube and the reagent bin respectively after a top sample adding mechanism loads a gun head, and sequentially carrying out liquid separation at a position corresponding to the reagent card;
s4, after the reaction time is over, transferring the reagent card to a reagent card transferring mechanism in a card bin by a transferring gripper in the sample adding mechanism, identifying and recording the two-dimensional code on the reagent card by a code scanning device in the card bin, simultaneously judging the result of a reagent card color development area, and after the judgment is finished, conveying the reagent card to the outside of the equipment by the reagent card transferring mechanism through a card discarding port.
It can be seen from the above description that the detector of this scheme contains: 1. sample adding part: completing the work of transferring the sample to the dry chemical reagent card and the work of transferring the reagent card; 2. a platform part: finishing the placing work of the reagent tube and the reagent card and finishing the code scanning work of the reagent tube; 3. a blocking part: finishing the storage work, the code scanning work and the interpretation work of the experimental result of the reagent card; the experimental process is as follows: 1. the card bin part scans and records the reagent card, and then the sample adding part transfers the reagent card to the platform part; 2. the platform part scans the code of the reagent tube, and then the sample adding part absorbs a certain amount of reagent and adds the sample in the reaction area on the reagent card; 3. after a period of reaction time, the sample adding part transfers the reagent card to an interpretation part in the card bin part to interpret the result, meanwhile, the card bin part carries out code scanning record on the reagent card again, finally, the card bin part transfers the reagent card to a waste card area, and the experiment is finished; in the instrument, a photoelectric sensor, a humidity sensor, a card pushing mechanism, a first electromagnet, a reagent card transferring mechanism, a code scanning device, an inner rotating platform, an outer rotating platform, a code scanning device, a second electromagnet, an X-direction guide rail, a Y-direction guide rail, a Z-direction guide rail, an air source, a vacuum pressure switch, a sample adding gun, a transferring gripper, a display screen and the like can be connected with an upper computer, the upper computer can adopt a computer for control, wherein the photoelectric sensor is used for counting the reagent cards in a card bin and transmitting the counting to the computer, and the computer displays the number of the reagent cards through the display screen; the humidity sensor is used for measuring the humidity in the card bin and transmitting the humidity information to the industrial control computer, and the humidity information is displayed through the display screen.
Drawings
FIG. 1 is a schematic structural diagram of an embodiment of the present invention.
FIG. 2 is a schematic view of the detector with the right side plate removed.
Fig. 3 is a schematic view of a card hopper without an air source.
Fig. 4 is a schematic view of the internal structure of the housing.
FIG. 5 is a schematic view of the structure of the sample application platform.
FIG. 6 is a schematic structural view of a sample adding mechanism.
In the figure, 1 is the shell, 2 is the card storehouse, 3 is the display screen, 4 is application of sample platform protecgulum, 5 is abandoning the bayonet socket, 6 is reagent card rack, 7 is reagent card transport mechanism, 8 is the air supply, 9 is pushing away the card mechanism, 10 is card storehouse protecgulum, 11 is card storehouse slide rail, 12 is sweeping yard device, 13 is first electro-magnet, 14 is application of sample mechanism, 15 is the application of sample platform, 16 is the bar code scanner, 17 is the test tube storehouse, 18 is the screens, 19 is disposable suction head placing area, 20 is the reagent storehouse, 21 is the second electro-magnet, 22 is the X direction guide rail, 23 is the Y direction guide rail, 24 is the Z direction guide rail, 25 is the transport tongs, 26 is linear electric motor, 27 is the sucking disc, 28 is the application of sample rifle, 29 is outer rotary platform, 30 is interior rotary platform, 31 is fixed platform, 32 is the platform slide rail.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only one embodiment of the present invention, and not all embodiments. All other embodiments that can be derived by a person skilled in the art from the detailed description of the invention without inventive step are within the scope of the invention.
As can be seen from the attached drawings, the solid phase method detector comprises a shell 1, wherein a sample adding mechanism 14 and a sample adding platform 15 are arranged in the shell 1, the sample adding mechanism 14 is arranged above the sample adding platform 15, and a card bin 2 for providing and recovering a reagent card is arranged on one side of the shell 1; and the card bin 2 is communicated with the shell 1, so that the reagent card in the card bin 2 can enter the sample adding platform 15 for experiment.
The sample adding mechanism 14 is used for transferring the reagent card from the card chamber 2 to the sample adding platform 15 or transferring the reagent card from the sample adding platform 15 to the card chamber 2; the sample adding platform 15 is used for placing test tubes and reagent cards to complete solid phase method experiments.
Card storehouse 2 include reagent card rack 6, set up below reagent card rack 6 and push away card mechanism 9, push away the exit of card mechanism 9 and set up reagent card transport mechanism 7, reagent card transport mechanism 7 stretch into application of sample platform 15 top. A photoelectric sensor for counting the reagent cards and a humidity sensor for measuring and detecting the humidity in the card chamber 2 are arranged in the card chamber 2. Reagent card rack 6 and push away card mechanism 9 and fix with card storehouse protecgulum 10, and card storehouse protecgulum 10 passes through card storehouse slide rail 11 with the casing in card storehouse 2 to be connected, sets up the first electro-magnet 13 that is used for adsorbing the card storehouse casing at the top of card storehouse protecgulum 10. Abandon bayonet socket 5 in card storehouse 2 one side of keeping away from the shell setting, abandon bayonet socket 5 and reagent card transport mechanism 7 and correspond. Set up the yard device 12 of sweeping that is used for discernment reagent card two-dimensional code in the top of reagent card transport mechanism 7, sweep yard device 12 and carry out the result interpretation to the reagent card after the colour rendering, and by equipment host computer with bar code content record in experimental data, can show through display screen 3, set up the positioner who is used for the reagent card location in one side that reagent card transport mechanism 7 is close to application of sample platform 15, positioner can be for the cardboard of L shape, be used for blockking and fix a position the reagent card.
The sample adding platform 15 comprises a drawer-type base, a sample adding platform front cover 4 is arranged at the front end of the base, the sample adding platform front cover 4 is convenient for drawing the sample adding platform 15, the base is connected with the shell 1 through a platform slide rail 32, an inner rotating platform 30, an outer rotating platform 29 and a fixed platform 31 are arranged on the base, the inner rotating platform 30 is arranged on the outer side of the fixed platform 31, the outer rotating platform 29 is arranged on the outer side of the inner rotating platform 30, a test tube bin 17 is arranged on the outer edge of the outer rotating platform 29 and used for clamping a test tube and driving the test tube to rotate, the test tube is clamped on the periphery of the outer rotating platform, a barcode label on the test tube faces the direction far away from the outer rotating platform, and a plurality of clamping positions 18 used for containing reagent cards are arranged on the inner rotating platform 30; a disposable suction head placing area 19 of a sample adding gun and a reagent bin 20 are arranged on the fixed platform 31, an opening is arranged on the base in the direction towards the rear part of the shell 1, a code scanner 16 for scanning a code of a bar code label of a test tube is arranged in the shell 1 corresponding to the opening, and the information scanned by the code scanner 16 records the content of the bar code in experimental data through an upper computer of the device and can be displayed through a display screen 3; a second electromagnet 21 for attracting the fixed base is provided in the housing 1.
The sample adding mechanism 14 comprises an X-direction guide rail 22 with a driving mechanism, a Y-direction guide rail 23 and a Z-direction guide rail 24, the X-direction guide rail 22 is fixed with the shell 1, the Y-direction guide rail 23 is installed on a guide slider of the X-direction guide rail 22 through a connecting piece, the Z-direction guide rail 24 is installed on a guide slider of the Y-direction guide rail 23 through a connecting piece, a sample adding gun 28 is installed on a guide slider of the Z-direction guide rail 24 through an adapter piece, and a transfer hand grip 25 is fixed on the Z-direction guide rail 24 and moves synchronously with the Z-direction guide rail 24; the X-direction guide rail 22 is used for carrying out X-direction movement on the sample adding gun 28 and the transferring hand grip 25; the Y-direction guide rail 23 is used for carrying out Y-direction movement on the sample adding gun 28 and the transferring hand grip 25; the Z-direction guide rail 24 is used for the sample adding gun 28 to move in the Z direction, and the transferring hand grip 25 is fixed with the Z-direction guide rail 24. The transfer hand grip 25 comprises a linear motor 26 fixed on the Z-direction guide rail 24, a sucker 27 used for adsorbing a reagent card is arranged at the front end of the linear motor 26, an air source 8 used for providing negative pressure for the sucker 27 is arranged in the card bin 2, and a vacuum pressure switch is arranged on a pipeline connected with the sucker 27 and the air source 8.
A detection method based on the solid phase method detector comprises the following steps:
s1, extracting a sample adding platform and a card bin mechanism, and respectively putting a sample, a reagent and a reagent card required by an experiment;
s2, pushing the reagent card to a reagent card transferring mechanism by a card pushing mechanism in the card bin structure, positioning the reagent card by the reagent card transferring mechanism and a positioning device, identifying the two-dimensional code on the reagent card by a code scanning device in the card bin, recording the two-dimensional code in experimental data, and transferring the reagent card to a card position on a rotating platform of a sample adding platform by a transferring gripper of the sample adding mechanism;
s3, identifying a bar code of the test tube on the sample adding platform and recording the bar code in experimental data, then rotating the test tube and the reagent card to an appointed position by the sample adding platform, carrying out liquid absorption on samples/reagents in the test tube and the reagent bin respectively after a top sample adding mechanism loads a gun head, and sequentially carrying out liquid separation at a position corresponding to the reagent card;
s4, after the reaction time is over, a transport gripper in the sample adding mechanism transfers the reagent card to a reagent card transport mechanism in a card bin, a code scanning device in the card bin identifies and records the two-dimensional code on the reagent card, and meanwhile, the result interpretation is carried out on a reagent card color development area, and after the interpretation is completed, the reagent card transport mechanism conveys the reagent card to the outside of the equipment through a card discarding opening.
Although particular embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these particular embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims (10)

1. A solid phase method detector is characterized in that: the device comprises a shell (1), wherein a sample adding mechanism (14) and a sample adding platform (15) are arranged in the shell (1), the sample adding mechanism (14) is arranged above the sample adding platform (15), and a card bin (2) for providing and recovering a reagent card is arranged on one side of the shell (1); the card bin (2) is communicated with the shell (1);
the sample adding mechanism (14) is used for transferring the reagent card from the card bin (2) to the sample adding platform (15) or transferring the reagent card from the sample adding platform (15) to the card bin (2) to finish the liquid transferring work of the sample to the dry chemical reagent card;
the sample adding platform (15) is used for placing test tubes and reagent cards.
2. The solid-phase method detector according to claim 1, wherein:
card storehouse (2) including reagent card rack (6), set up in reagent card rack (6) below and push away card mechanism (9), the exit that pushes away card mechanism (9) sets up reagent card transport mechanism (7), reagent card transport mechanism (7) stretch into application of sample platform (15) top, set up in card storehouse (2) and be used for carrying out the photoelectric sensing ware of count and be used for surveying the humidity sensor who detects humidity in card storehouse (2) to the reagent card.
3. The solid-phase method detector according to claim 2, wherein:
reagent card rack (6) and push away card mechanism (9) and card storehouse protecgulum (10) fixed, card storehouse protecgulum (10) are connected through card storehouse slide rail (11) with the casing in card storehouse (2), set up first electro-magnet (13) that are used for adsorbing the card storehouse casing at the top in card storehouse protecgulum (10).
4. The solid-phase method detector according to claim 2, wherein:
one side of keeping away from shell (1) in card storehouse (2) sets up abandons bayonet socket (5), abandon bayonet socket (5) and reagent card transport mechanism (7) correspond.
5. The solid-phase method detection instrument according to claim 2, wherein:
a code scanning device (12) is arranged above the reagent card transferring mechanism (7), and the code scanning device (12) is used for identifying the two-dimensional code of the reagent card and interpreting the result of the developed reagent card; and a positioning device for positioning the reagent card is arranged on one side of the reagent card transfer mechanism (7) close to the sample adding platform (15).
6. The solid-phase method detection instrument according to claim 1, wherein:
the sample adding platform (15) comprises a drawer-type base, the base is connected with the shell (1) through a platform sliding rail (32), an inner rotating platform (30), an outer rotating platform (29) and a fixed platform (31) are arranged on the base, the inner rotating platform (30) is arranged on the outer side of the fixed platform (31), and the outer rotating platform (29) is arranged on the outer side of the inner rotating platform (30); the outer edge of the outer rotary platform (29) clamps the test tube and drives the test tube to rotate, the test tube is clamped at the periphery of the outer rotary platform (29), the bar code label on the test tube faces the direction far away from the outer rotary platform (29), and a plurality of clamping positions (18) for containing reagent cards are arranged on the inner rotary platform (30); the fixed platform (31) is provided with a sample adding gun disposable suction head placing area (19) and a reagent bin (20).
7. The solid-phase method detector according to claim 6, wherein:
the direction of base towards shell (1) rear portion be provided with the opening, correspond the opening part setting in shell (1) and be used for sweeping bar code label of test tube bar code sign indicating number ware (16), set up second electro-magnet (21) that are used for adsorbing unable adjustment base in shell (1).
8. The solid-phase method detector according to claim 1, wherein:
the sample adding mechanism (14) comprises an X-direction guide rail (22) with a driving mechanism, a Y-direction guide rail (23) and a Z-direction guide rail (24), the X-direction guide rail (22) is fixed with the shell (1), the Y-direction guide rail (23) is installed on a guide slider of the X-direction guide rail (22) through a connecting piece, the Z-direction guide rail (24) is installed on a guide slider of the Y-direction guide rail (23) through a connecting piece, a sample adding gun (28) is installed on a guide slider of the Z-direction guide rail (24) through an adapter piece, and a transfer gripper (25) is fixed on the Z-direction guide rail (24);
the X-direction guide rail (22) is used for carrying out X-direction movement on the sample adding gun (28) and the transfer gripper (25); the Y-direction guide rail (23) is used for carrying out Y-direction movement on the sample adding gun (28) and the transferring gripper (25); the Z-direction guide rail (24) is used for the sample adding gun (28) to move in the Z direction, and the transferring gripper (25) is fixed with the Z-direction guide rail.
9. The solid-phase method detector according to claim 8, wherein:
transport tongs (25) including fixing linear electric motor (26) on Z direction guide rail (24), set up sucking disc (27) that are used for adsorbing the reagent card at the front end of linear electric motor (26), set up air supply (8) that are used for providing the negative pressure for sucking disc (27) in card storehouse (2), set up vacuum pressure switch on the pipeline that sucking disc (27) and air supply (8) are connected.
10. A detection method based on any solid phase method detector in claims 1-9 is characterized by comprising the following steps:
s1, extracting the sample adding platform and the card bin mechanism, and respectively putting a sample, a reagent and a reagent card required by an experiment;
s2, pushing the reagent card to a reagent card transferring mechanism by a card pushing mechanism in the card bin structure, positioning the reagent card by the reagent card transferring mechanism and a positioning device, identifying the two-dimensional code on the reagent card by a code scanning device in the card bin, recording the two-dimensional code in experimental data, and transferring the reagent card to a card position on a rotating platform of a sample adding platform by a transferring gripper of the sample adding mechanism;
s3, identifying the bar codes of the test tubes on the sample adding platform and recording the bar codes in experimental data, then rotating the test tubes and the reagent cards to the specified positions by the sample adding platform, carrying out imbibition on the samples/reagents in the test tubes and in the reagent bins respectively after a gun head is loaded by a sample adding mechanism at the top, and sequentially carrying out liquid separation at the corresponding positions of the reagent cards;
s4, after the reaction time is over, the reagent card is transferred to a reagent card transferring mechanism in the card bin by a gripper in the sample adding mechanism, the two-dimensional code on the reagent card is identified and recorded by a code scanning device in the card bin, the result interpretation is carried out on a reagent card color development area, and after the interpretation is finished, the reagent card transferring mechanism conveys the reagent card to the outside of the equipment through a card discarding port.
CN202210992523.3A 2022-08-18 2022-08-18 Solid phase method detector and detection method Pending CN115561164A (en)

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Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
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Publication Number Publication Date
CN115561164A true CN115561164A (en) 2023-01-03

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Country Link
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