CN115558560A - 一种细菌生物膜絮凝剂 - Google Patents

一种细菌生物膜絮凝剂 Download PDF

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CN115558560A
CN115558560A CN202111580948.5A CN202111580948A CN115558560A CN 115558560 A CN115558560 A CN 115558560A CN 202111580948 A CN202111580948 A CN 202111580948A CN 115558560 A CN115558560 A CN 115558560A
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张万国
邹贤信
周鑫鑫
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Likang Pharmaceutical Technology Jiangsu Co ltd
Shanghai Likang Disinfection High Tech Co ltd
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Abstract

本发明涉及医用清洗剂，尤其涉及一种生物膜絮凝剂。一种细菌生物膜絮凝剂，它的组分为：阳离子化合物10％‑20％，两性离子表面活性剂椰油酰胺丙基甜菜碱5％‑10％，渗透剂1％‑5％，脂质溶解剂5％‑10％，络合剂0.5％‑3％，pH调节剂无机钠盐0.1％‑0.5％，余量为水。将阳离子化合物和两性离子表面活性剂加入水中搅拌溶解，依次加入渗透剂、脂质溶解剂、络合剂，搅拌溶解，最后加pH调节剂调节pH＝7.0‑9.0。使用时稀释600倍。本发明能与细菌生物膜结合，瓦解细菌生物膜的脂质结构，使细菌生物膜快速絮凝剥离脱落。

Description

一种细菌生物膜絮凝剂
技术领域
本发明涉及医用清洗剂，尤其涉及一种生物膜絮凝剂。
背景技术
生物膜已经成为很多行业长期难以解决的问题，如食品饮料生产的管道、制药行业的纯化水管道、医疗器械等物体表面，一旦滋生细菌形成生物膜，消毒及灭菌因子均难以杀灭包裹于其中的细菌。
细菌生物膜是由细菌及自身产生的多糖基质、纤维蛋白质、脂蛋白等包裹着的菌细胞的结构群体。生物膜表面的聚合物错综复杂,形成牢固有序的整体构造,有效保护生物膜在载体表面的稳定性。生物膜中的微生物以团簇的形式在一起，牢牢吸附在载体表面，很难被清除。
发明内容
本发明旨在解决现有技术的上述缺陷，提供一种细菌生物膜絮凝剂。本发明本发明细菌生物膜絮凝剂，能与细菌生物膜结合，瓦解细菌生物膜的脂质结构，使细菌生物膜快速絮凝剥离脱落。
本发明是这样实现的，一种细菌生物膜絮凝剂，它的组分为：阳离子化合物10％-20％，两性离子表面活性剂椰油酰胺丙基甜菜碱5％-10％，渗透剂1％-5％，脂质溶解剂5％-10％，络合剂0.5％-3％，pH调节剂无机钠盐0.1％-0.5％，余量为水。
所述的一种细菌生物膜絮凝剂，所述的阳离子化合物为烷基二甲基氯化铵或烷基苯基氯化铵或合用。
所述的一种细菌生物膜絮凝剂，所述的渗透剂为二甲基酰胺或尿素。
所述的一种细菌生物膜絮凝剂，所述的脂质溶解剂为二乙二醇丁醚或二丙二醇甲醚。
所述的一种细菌生物膜絮凝剂，所述的络合剂为羟基乙叉二膦酸或二乙烯三胺五甲叉膦酸。
所述的一种细菌生物膜絮凝剂，述的无机钠盐pH调节剂为磷酸钠或碳酸钠。
一种所述的任一种细菌生物膜絮凝剂的制备方法，它包括：将阳离子化合物和两性离子表面活性剂加入水中搅拌溶解，依次加入渗透剂、脂质溶解剂、络合剂，搅拌溶解，最后加pH调节剂调节pH＝7.0-9.0。
一种所述的一种细菌生物膜絮凝剂，所述絮凝剂稀释100-600倍使用。
本发明利用渗透剂的穿透力，促进脂质溶解剂进入生物膜，溶化破坏生物膜的脂质基底，消除生物膜在物体表面的附着力；络合剂与基底残留结合，带正电荷的阳离子化合物与带负电荷的细菌表面结合，在两性离子表面活性剂的清洗作用下，合力将细菌生物膜快速絮凝剥离脱落。
依据《医用清洗剂卫生要求》T/WSJT002-2019附录F的生物膜去除效果测定，在40℃条件下作用30min，本发明细菌生物膜絮凝剂600倍稀释液对人工制备生物膜中细菌的去除率为91.64％，去除率>90.00％；ATP含量下降率为90.83％，下降率>90.00％，符合《医用清洗剂卫生要求》T/WSJT002-2019附录F.8的要求。
具体实施方式
下面，对结合实施例对本发明做进一步的说明。
一种细菌生物膜絮凝剂，它的组分为：阳离子化合物10％-20％，椰油酰胺丙基甜菜碱5％-10％，渗透剂1％-5％，脂质溶解剂5％-10％，络合剂0.5％-3％，pH调节剂无机钠盐0.1％-0.5％，余量为水。
所述的渗透剂为二甲基酰胺或尿素。
所述的脂质溶解剂为二乙二醇丁醚或二丙二醇甲醚。
所述的络合剂为羟基乙叉二膦酸或二乙烯三胺五甲叉膦酸。
述的无机钠盐pH调节剂为磷酸钠或碳酸钠。
将阳离子化合物和两性离子表面活性剂加入水中搅拌溶解，依次加入渗透剂、脂质溶解剂、络合剂，搅拌溶解，最后加pH调节剂调节pH＝7.0-9.0。
一种所述的一种细菌生物膜絮凝剂，所述絮凝剂稀释100-600倍使用。
实施例1
细菌生物膜絮凝剂的组分为：烷基苯基氯化铵10％，椰油酰胺丙基甜菜碱10％，二甲基酰胺3％，二丙二醇甲醚10％，羟基乙叉二膦酸2％，磷酸钠0.35％，余量为水。
将烷基二甲基氯化铵和椰油酰胺丙基甜菜碱加入水中搅拌溶解，依次加入二甲基酰胺、二丙二醇甲醚、羟基乙叉二膦酸，搅拌溶解，最后加入碳酸钠调节pH＝8.8得到浓缩液。
将制备的浓缩液用蒸馏水稀释150倍后按照《医用清洗剂卫生要求》T/WSJT002-2019附录F的生物膜去除效果测定，在40℃条件下作用30min，对人工制备生物膜中细菌的去除率为95.64％，去除率>90.00％；ATP含量下降率为91.83％，下降率>90.00％，符合《医用清洗剂卫生要求》T/WSJT002-2019附录F.8的要求。
实施例2
细菌生物膜絮凝剂的组分为：烷基苯基氯化铵15％，椰油酰胺丙基甜菜碱8％，尿素4％，二乙二醇丁醚7％，二乙烯三胺五甲叉膦酸2％，磷酸钠0.35％，余量为水。所述的阳离子化合物为或烷基苯基氯化铵或合用。
将烷基苯基氯化铵和椰油酰胺丙基甜菜碱加入水中搅拌溶解，依次加入尿素、二乙二醇丁醚、二乙烯三胺五甲叉膦酸，搅拌溶解，最后加入碳酸钠pH＝7.0，得到浓缩液。
将制备的浓缩液用蒸馏水稀释400倍后按照《医用清洗剂卫生要求》T/WSJT002-2019附录F的生物膜去除效果测定，在40℃条件下作用30min，对人工制备生物膜中细菌的去除率为93.16％，去除率>90.00％；ATP含量下降率为91.21％，下降率>90.00％，符合《医用清洗剂卫生要求》T/WSJT002-2019附录F.8的要求。
实施例3
细菌生物膜絮凝剂的组分为：烷基二甲基氯化铵或烷基苯基氯化铵合计20％，椰油酰胺丙基甜菜碱10％，尿素5％，二乙二醇丁醚7％，羟基乙叉二膦酸3％，磷酸钠0.5％，余量为水。所述的阳离子化合物为或烷基苯基氯化铵或合用。
将烷基苯基氯化铵和椰油酰胺丙基甜菜碱加入水中搅拌溶解，依次加入尿素、二乙二醇丁醚、二乙烯三胺五甲叉膦酸，搅拌溶解，最后加入碳酸钠pH＝7.0，得到浓缩液。
将制备的浓缩液用蒸馏水稀释300倍后按照《医用清洗剂卫生要求》T/WSJT002-2019附录F的生物膜去除效果测定，在40℃条件下作用30min，对人工制备生物膜中细菌的去除率为93.16％，去除率>90.00％；ATP含量下降率为91.21％，下降率>90.00％，符合《医用清洗剂卫生要求》T/WSJT002-2019附录F.8的要求。
实施例4
细菌生物膜絮凝剂的组分为：烷基二甲基氯化铵和烷基苯基氯化铵合计18％，椰油酰胺丙基甜菜碱9％，尿素4％，二乙二醇丁醚7％，二乙烯三胺五甲叉膦酸2.8％，磷酸钠0.45％，余量为水。所述的阳离子化合物为或烷基苯基氯化铵或合用。
将烷基二甲基氯化铵、烷基苯基氯化铵和椰油酰胺丙基甜菜碱加入水中搅拌溶解，依次加入尿素、二乙二醇丁醚、二乙烯三胺五甲叉膦酸，搅拌溶解，最后加入碳酸钠pH＝9.0，得到浓缩液。
将制备的浓缩液用蒸馏水稀释600倍后按照《医用清洗剂卫生要求》T/WSJT002-2019附录F的生物膜去除效果测定，在40℃条件下作用30min，对人工制备生物膜中细菌的去除率为91.64％，去除率>90.00％；ATP含量下降率为90.83％，下降率>90.00％，符合《医用清洗剂卫生要求》T/WSJT002-2019附录F.8的要求。

Claims (8)

1.一种细菌生物膜絮凝剂，其特征在于，它的组分为：阳离子化合物10％-20％，两性离子表面活性剂椰油酰胺丙基甜菜碱5％-10％，渗透剂1％-5％，脂质溶解剂5％-10％，络合剂0.5％-3％，pH调节剂无机钠盐0.1％-0.5％，余量为水。
2.根据权利要求1所述的一种细菌生物膜絮凝剂，其特征在于，所述的阳离子化合物为烷基二甲基氯化铵或烷基苯基氯化铵或合用。
3.根据权利要求1所述的一种细菌生物膜絮凝剂，其特征在于，所述的渗透剂为二甲基酰胺或尿素。
4.根据权利要求1所述的一种细菌生物膜絮凝剂，其特征在于，所述的脂质溶解剂为二乙二醇丁醚或二丙二醇甲醚。
5.根据权利要求1所述的一种细菌生物膜絮凝剂，其特征在于，所述的络合剂为羟基乙叉二膦酸或二乙烯三胺五甲叉膦酸。
6.根据权利要求1所述的一种细菌生物膜絮凝剂，其特征在于，所述的无机钠盐pH调节剂为磷酸钠或碳酸钠。
7.一种如利要求1-6所述的任一种细菌生物膜絮凝剂的制备方法，其特征在于，它包括：将阳离子化合物和两性离子表面活性剂加入水中搅拌溶解，依次加入渗透剂、脂质溶解剂、络合剂，搅拌溶解，最后加pH调节剂调节pH＝7.0-9.0。
8.一种如权利要求1所述的一种细菌生物膜絮凝剂，其特征在于，所述絮凝剂稀释100-600倍使用。
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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005120592A1 (en) * 2004-06-08 2005-12-22 Whiteley Corporation Pty Ltd Biofilm remover
CN108130219A (zh) * 2016-12-01 2018-06-08 黎凯华 一种生物膜清除剂
CN111039367A (zh) * 2019-11-29 2020-04-21 西安石油大学 一种水处理系统用高效复配溶垢杀菌剂及其制备方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005120592A1 (en) * 2004-06-08 2005-12-22 Whiteley Corporation Pty Ltd Biofilm remover
CN108130219A (zh) * 2016-12-01 2018-06-08 黎凯华 一种生物膜清除剂
CN111039367A (zh) * 2019-11-29 2020-04-21 西安石油大学 一种水处理系统用高效复配溶垢杀菌剂及其制备方法

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