CN115551869B - 稠环2-吡啶酮化合物、其制备方法及其在治疗和/或预防涉及革兰氏阳性菌的疾病中的用途 - Google Patents

稠环2-吡啶酮化合物、其制备方法及其在治疗和/或预防涉及革兰氏阳性菌的疾病中的用途 Download PDF

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Publication number
CN115551869B
CN115551869B CN202180033962.5A CN202180033962A CN115551869B CN 115551869 B CN115551869 B CN 115551869B CN 202180033962 A CN202180033962 A CN 202180033962A CN 115551869 B CN115551869 B CN 115551869B
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oxo
thiazolo
cyclopropyl
pyridine
cyclobutane
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Chinese (zh)
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CN115551869A (zh
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F·阿尔姆奎斯特
P·辛格
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QURETECH BIO AB
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QURETECH BIO AB
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN202180033962.5A 2020-05-08 2021-05-07 稠环2-吡啶酮化合物、其制备方法及其在治疗和/或预防涉及革兰氏阳性菌的疾病中的用途 Active CN115551869B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE2050543 2020-05-08
SE2050543-4 2020-05-08
PCT/EP2021/062237 WO2021224501A1 (en) 2020-05-08 2021-05-07 Ring-fused 2-pyridone compounds, methods for preparation thereof and their use in the treatment and/or prevention of a disease involving gram-positive bacteria

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CN115551869A CN115551869A (zh) 2022-12-30
CN115551869B true CN115551869B (zh) 2024-01-02

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CN202180033962.5A Active CN115551869B (zh) 2020-05-08 2021-05-07 稠环2-吡啶酮化合物、其制备方法及其在治疗和/或预防涉及革兰氏阳性菌的疾病中的用途

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US (1) US12503476B2 (https=)
EP (1) EP4146659B1 (https=)
JP (1) JP7741817B2 (https=)
CN (1) CN115551869B (https=)
DK (1) DK4146659T3 (https=)
ES (1) ES3017588T3 (https=)
PL (1) PL4146659T3 (https=)
WO (1) WO2021224501A1 (https=)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016075296A1 (en) * 2014-11-13 2016-05-19 Quretech Bio Ab 2,3-dihydro-thiazolo[3,2-a]pyridin-5-one derivatives, intermediates thereof, and their use as antibacerial agents
WO2017175182A1 (en) * 2016-04-08 2017-10-12 Quretech Bio Ab Ring-fused thiazolino 2-pyridones, methods for preparation thereof and their use in the treatment and/or prevention of tuberculosis
WO2018229141A1 (en) * 2017-06-13 2018-12-20 Quretech Bio Ab Ring-fused thiazolino 2-pyridones, methods for preparation thereof and their use in the treatment and/or prevention of a disease involving gram-positive bacteria
WO2019068910A1 (en) * 2017-10-05 2019-04-11 Quretech Bio Ab THIAZOLINO 2-PYRIDONES WITH A FUSED CYCLE IN COMBINATION WITH A MEDICINE AGAINST TUBERCULOSIS

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6841559B1 (en) * 1999-11-19 2005-01-11 Washington University Of St. Louis Pyridinones to treat and prevent bacterial infections
WO2014185853A1 (en) 2013-05-14 2014-11-20 Quretech Bio Ab Compounds and methods for treatment of chlamydia infections

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016075296A1 (en) * 2014-11-13 2016-05-19 Quretech Bio Ab 2,3-dihydro-thiazolo[3,2-a]pyridin-5-one derivatives, intermediates thereof, and their use as antibacerial agents
WO2017175182A1 (en) * 2016-04-08 2017-10-12 Quretech Bio Ab Ring-fused thiazolino 2-pyridones, methods for preparation thereof and their use in the treatment and/or prevention of tuberculosis
WO2018229141A1 (en) * 2017-06-13 2018-12-20 Quretech Bio Ab Ring-fused thiazolino 2-pyridones, methods for preparation thereof and their use in the treatment and/or prevention of a disease involving gram-positive bacteria
WO2019068910A1 (en) * 2017-10-05 2019-04-11 Quretech Bio Ab THIAZOLINO 2-PYRIDONES WITH A FUSED CYCLE IN COMBINATION WITH A MEDICINE AGAINST TUBERCULOSIS

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Publication number Publication date
EP4146659A1 (en) 2023-03-15
JP2023525280A (ja) 2023-06-15
EP4146659B1 (en) 2025-02-26
WO2021224501A1 (en) 2021-11-11
US12503476B2 (en) 2025-12-23
CN115551869A (zh) 2022-12-30
DK4146659T3 (en) 2025-04-14
ES3017588T3 (en) 2025-05-13
JP7741817B2 (ja) 2025-09-18
PL4146659T3 (pl) 2025-06-23
US20230339973A1 (en) 2023-10-26

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