CN115536567B - 含有光亲和基团双吖丙啶的β-榄香烯衍生物及其制备方法和作为光亲和分子探针的应用 - Google Patents

含有光亲和基团双吖丙啶的β-榄香烯衍生物及其制备方法和作为光亲和分子探针的应用 Download PDF

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CN115536567B
CN115536567B CN202211212049.4A CN202211212049A CN115536567B CN 115536567 B CN115536567 B CN 115536567B CN 202211212049 A CN202211212049 A CN 202211212049A CN 115536567 B CN115536567 B CN 115536567B
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elemene
beta
photoaffinity
compound
derivative
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CN115536567A (zh
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谢恬
叶向阳
章映茜
毛晴
吴晨源
白仁仁
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Hangzhou Normal University
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Hangzhou Normal University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN202211212049.4A 2022-09-30 2022-09-30 含有光亲和基团双吖丙啶的β-榄香烯衍生物及其制备方法和作为光亲和分子探针的应用 Active CN115536567B (zh)

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CN202211212049.4A CN115536567B (zh) 2022-09-30 2022-09-30 含有光亲和基团双吖丙啶的β-榄香烯衍生物及其制备方法和作为光亲和分子探针的应用
PCT/CN2023/102980 WO2024066548A1 (fr) 2022-09-30 2023-06-28 DÉRIVÉ DE β-ÉLÉMÈNE CONTENANT UNE DIAZIRINE DE GROUPE DE PHOTOAFFINITÉ, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION EN TANT QUE SONDE MOLÉCULAIRE DE PHOTOAFFINITÉ

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CN202211212049.4A CN115536567B (zh) 2022-09-30 2022-09-30 含有光亲和基团双吖丙啶的β-榄香烯衍生物及其制备方法和作为光亲和分子探针的应用

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Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115536567B (zh) * 2022-09-30 2023-09-26 杭州师范大学 含有光亲和基团双吖丙啶的β-榄香烯衍生物及其制备方法和作为光亲和分子探针的应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1850779A (zh) * 2006-05-10 2006-10-25 沈阳药科大学 β－榄香烯含氮衍生物及其制备方法和用途
CN106866418A (zh) * 2017-01-19 2017-06-20 石药集团远大(大连)制药有限公司 β‑榄香烯二聚体衍生物、其制备方法及其用途
CN109593062A (zh) * 2018-11-02 2019-04-09 苏州光点生物科技有限公司 一种土槿皮乙酸光亲和探针双吖丙啶基中间体及其制备方法
CN111087344A (zh) * 2019-11-19 2020-05-01 南京理工大学 含有双吖丙啶基团的氨基酸类化合物及其合成方法
CN114907197A (zh) * 2022-05-08 2022-08-16 中国人民解放军海军军医大学 一种双吖丙啶基光交联探针中间体及衍生物的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060014987A1 (en) * 2003-07-07 2006-01-19 Lan Huang Synthesis of beta-elemene, intermediates thereto, analogues and uses thereof
CN114591201B (zh) * 2022-02-28 2024-06-25 杭州师范大学 具有HDACi药效团的β-榄香烯衍生物及其制备方法和应用
CN115536567B (zh) * 2022-09-30 2023-09-26 杭州师范大学 含有光亲和基团双吖丙啶的β-榄香烯衍生物及其制备方法和作为光亲和分子探针的应用

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1850779A (zh) * 2006-05-10 2006-10-25 沈阳药科大学 β－榄香烯含氮衍生物及其制备方法和用途
CN106866418A (zh) * 2017-01-19 2017-06-20 石药集团远大(大连)制药有限公司 β‑榄香烯二聚体衍生物、其制备方法及其用途
CN109593062A (zh) * 2018-11-02 2019-04-09 苏州光点生物科技有限公司 一种土槿皮乙酸光亲和探针双吖丙啶基中间体及其制备方法
CN111087344A (zh) * 2019-11-19 2020-05-01 南京理工大学 含有双吖丙啶基团的氨基酸类化合物及其合成方法
CN114907197A (zh) * 2022-05-08 2022-08-16 中国人民解放军海军军医大学 一种双吖丙啶基光交联探针中间体及衍生物的制备方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Jichao Chen等.Antioxidant Properties of Novel Dimers Derived from Natural β-Elemene through Inhibiting H2O2-Induced Apoptosis.《ACS Medicinal Chemistry Letters》.2017,第8卷(第4期),第443-448页. *

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WO2024066548A1 (fr) 2024-04-04

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