CN115518140A - 一种治疗中风后遗症的中药组合物及其制备方法 - Google Patents
一种治疗中风后遗症的中药组合物及其制备方法 Download PDFInfo
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- CN115518140A CN115518140A CN202211297806.2A CN202211297806A CN115518140A CN 115518140 A CN115518140 A CN 115518140A CN 202211297806 A CN202211297806 A CN 202211297806A CN 115518140 A CN115518140 A CN 115518140A
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Abstract
本发明公开了一种治疗中风后遗症的中药组合物,涉及中药组合物技术领域,该中药组合物包括如下重量份的原料:黄芪100‑2000份,当归90‑300份,川芎80‑750份,赤芍70‑500份,丹参80‑750份,红花50‑250份,桃仁50‑250份,郁金80‑750份,远志35‑350份,葛根80‑300份,三七70‑500份,土元80‑750份,地龙80‑750份,水蛭90‑800份,乌梢蛇65‑700份,毛冬青100‑350份,石菖蒲70‑500份,鸡血藤70‑500份,豨莶草100‑400份,威灵仙80‑750份,川牛膝70‑500份。该中药组合物具有益气活血、化痰、通络开窍、散瘀止痛的功效,对中风引起的半身不遂、口眼歪斜、流口水、肢体麻木具有良好的疗效,此外还对胸痹导致的胸闷气短、心悸、胸痛也具有良好的疗效,并对早期股骨头坏死也具有良好的疗效。
Description
技术领域
本发明涉及中药组合物技术领域,具体为一种治疗中风后遗症的中药组合物及其制备方法。
背景技术
中风,又称脑卒中,是由于脑血管破裂或阻塞导致脑组织损伤的一种急性病,脑血管破裂导致的中风为出血性卒中,俗称“脑溢血”、“脑出血”,血管阻塞导致的中风为缺血性卒中,俗称“脑梗”。中风表现为突然昏倒、不省人事,伴发口歪眼斜、言语不清等症状,并容易因摔倒导致头部、四肢骨折等外伤,发病致死率高,即使及时治疗挽回性命,也会不同程度地留下半身不遂、肢体麻木等后遗症。
目前针对中风后遗症多通过巴氯芬、氯吡格雷、血塞通等药物进行治疗,但这些药物针对性较强,往往只针对特定部位的后遗症进行治疗,而中风后遗症通常为多种症状并发,单一用药难以对多个部位的并发症进行全面治疗,往往需要同时服用多种药品,需要考虑各个药物之间的配合和拮抗作用,使治疗方案变得复杂,同时副作用、不良反应的发生风险大幅提升。
发明内容
本发明的目的在于:提供一种治疗中风后遗症的中药组合物,以实现对中风导致的半身不遂、肢体麻木、口歪眼斜等后遗症进行全面治疗的目的。
本发明的目的还在于:提供上述中药组合物的制备方法及应用。
本发明采用的技术方案如下:
一种治疗中风后遗症的中药组合物,包括如下重量份的原料:
黄芪100-2000份,当归90-300份,川芎80-750份,
赤芍70-500份,丹参80-750份,红花50-250份,
桃仁50-250份,郁金80-750份,远志35-350份,
葛根80-300份,三七70-500份,土元80-750份,
地龙80-750份,水蛭90-800份,乌梢蛇65-700份,
毛冬青100-350份,石菖蒲70-500份,鸡血藤70-500份,
豨莶草100-400份,威灵仙80-750份,川牛膝70-500份。
优选的,包括如下重量份的原料:
黄芪1250-1800份,当归110-180份,川芎500-600份,
赤芍110-250份,丹参120-180份,红花90-150份,
桃仁90-150份,郁金120-200份,远志105-150份,
葛根180-200份,三七200-300份,土元80-120份,
地龙350-450份,水蛭300-600份,乌梢蛇95-180份,
毛冬青110-150份,石菖蒲170-200份,鸡血藤100-300份,
豨莶草100-400份,威灵仙90-150份,川牛膝100-300份。
优选的,由如下重量份的原料组成:
黄芪1350份,当归170份,川芎500份,
赤芍170份,丹参150份,红花110份,
桃仁120份,郁金150份,远志125份,
葛根180份,三七200份,土元100份,
地龙350份,水蛭400份,乌梢蛇150份,
毛冬青110份,石菖蒲170份,鸡血藤150份,
豨莶草180份,威灵仙120份,川牛膝220份。
本发明中药组合物的药理如下:
葛根,药性甘、辛、凉,归脾、胃、肺经,具有解肌退热、生津、透疹、通经活络之功效。
三七,药性甘、微苦、温,归肝、胃经,具有散瘀止血、消肿定痛之功效。
土元,咸、寒、有小毒,归肝经,具有下瘀血、消症瘕、疗折伤、散瘀止痛之功效。
地龙,味咸、性寒,归肝经、脾经、膀胱经,具有清热止痉、平肝熄风、通经活络、平喘利尿之功效。
水蛭,咸、苦、平、有毒,入肝、膀胱经,具有破血逐瘀、通经消症瘕之功效。
乌梢蛇,甘、平,归肝经,具有祛风、活络、止惊之功效。
黄芪,甘、微温;归脾、肺经,具有健脾补中、升阳举陷、益卫固表、利尿、托毒生肌之功效。
当归,性甘、辛、温,归肝、心、脾经,具有补血、活血、调经止痛、润燥滑肠之功效。
川芎,辛、温,入肝、胆经,具有行气开郁、祛除风燥湿、活血止痛之功效。
赤芍,味苦、性微寒,归肝经,具有清热凉血、散瘀止痛之功效。
丹参,味苦、微寒,归心、肝经,具有活血祛瘀、通经止痛、清心除烦、凉血消痈之功效。
红花,辛、温,入心、肝经,具有活血通经、祛瘀止痛之功效。
桃仁,苦、甘、平,归心、肝、大肠经,具有活血祛瘀、润肠通便、止咳平喘之功效。
郁金,辛、苦、寒,归肝、心、肺经,具有活血止痛、行气解郁、清心凉血、利胆退黄之功效。
远志,苦、辛、温,归心、肾、肺经,具有安神益智、解郁之功效。
毛冬青,性味辛、苦、寒,归心经,具有清热解毒、活血通络之功效。
石菖蒲,味辛、苦、微温。归心、肝、脾经,具有化痰开窍、化湿行气、祛风利痹、消肿止痛之功效。
鸡血藤,苦、甘、温,归肝、肾经,具有活血补血、调经止痛、舒筋活络之功效。
豨莶草,苦、寒。归肝、肾经,具有祛除风湿、强健筋骨、清热解毒之功效。
威灵仙,味辛、咸、性温,具有归膀胱经、祛风湿、通经络之功效。
川牛膝,味甘、微苦、性平,归肝、肾经,具有逐瘀通经、通利关节、利尿通淋之功效。
本发明的中药组合物,具有益气活血、化痰、通络开窍、散瘀止痛的功效,对中风引起的半身不遂、口眼歪斜、流口水、肢体麻木具有良好的疗效。
本发明还公开了上述中药组合物的制备方法,包括如下步骤:
S1:将葛根、三七、土元、地龙、水蛭、乌梢蛇粉碎成1mm以下的药粉;
S2:将剩余药材水煎1次,分离出滤液;
S3:取步骤S2分离出的药渣,再次水煎1次,分离出滤液并与S2的滤液合并;
S4:将步骤S3合并后的滤液与S1制得的药粉混合均匀,烘干,即得。
优选的,步骤S1中,将葛根、三七、土元、地龙、水蛭、乌梢蛇粉碎,粉碎后的药粉100目筛网筛余率不超过5%。
优选的,还包括如下步骤:将步骤S4得到的中药组合物制成口服剂型。
优选的,所述剂型包括丸剂、片剂、胶囊、散剂、丸剂、丹剂、锭剂。
本发明还公开了上述中药组合物在制备治疗中风后遗症药物中的应用。
本发明还公开了上述中药组合物在制备治疗胸痹药物中的应用。
本发明还公开了上述中药组合物在制备治疗股骨头坏死药物中的应用。
综上所述,由于采用了上述技术方案,本发明的有益效果是:
(1)本发明公开的中药组合物具有益气、活血化瘀、通络开窍、止疼的功效,对中风引起的半身不遂、口眼歪斜、流口水、肢体麻木等症状具有良好的治疗效果,治疗有效率达到92.3%,并对胸痹引起的胸闷气短、心悸、胸痛也具有良好的疗效,门诊胸痹患者治疗有效率为90.2%;
(2)在临床实践中发现,本发明的中药组合物对于早期股骨头坏死也具有一定的治疗效果,I、Ⅱ期股骨头坏死治疗有效率达到100%。
具体实施方式
为了使本发明的目的、技术方案及优点更加清楚明白,以下结合实施例,对本发明进行进一步详细说明,应当理解,此处所描述的具体实施例仅用以解释本发明,并不用于限定本发明。
实施例1
精确称取葛根18g,三七20g,土元10g,地龙35g,水蛭40g,乌梢蛇15g,粉碎至100目筛网筛余率不超过5%,备用。
精确称取黄芪135g,当归17g,川芎5g,赤芍17g,丹参15g,红花11g,桃仁12g,郁金15g,远志12g,毛冬青11g,石菖蒲17g,鸡血藤15g,川牛膝22g,加入5倍药材总重的水煎煮3小时,使用纱布过滤,保留滤液,滤渣再次加同样重量的水煎煮2小时,使用纱布过滤,合并两次煎煮的滤液,备用。
将上述药粉与合并后的滤液倒入剪切机中,5000转混合20分钟,将其混合均匀,再倒入烘干机中烘干,即得治疗中风后遗症的中药组合物。
实施例2
精确称取葛根8g,三七20g,土元10g,地龙35g,水蛭40g,乌梢蛇15g,粉碎至100目筛网筛余率不超过5%,备用。
精确称取黄芪135g,当归17g,川芎50g,赤芍15g,丹参15g,红花11g,桃仁12g,郁金15g,远志12g,毛冬青11g,石菖蒲17g,鸡血藤15g,豨莶草18g,川牛膝22g,加入5倍药材总重的水煎煮3小时,使用纱布过滤,保留滤液,滤渣再次加同样重量的水煎煮2小时,使用纱布过滤,合并两次煎煮的滤液,备用。
将上述药粉与合并后的滤液倒入剪切机中,5000转混合20分钟,将其混合均匀,再倒入烘干机中烘干,即得治疗中风后遗症的中药组合物。
实施例3
精确称取葛根18g,三七25g,土元8g,地龙40g,水蛭30g,乌梢蛇9g,粉碎至100目筛网筛余率不超过5%,备用。
精确称取黄芪180g,当归17g,川芎55g,赤芍20g,丹参16g,红花14g,桃仁12g,郁金18g,远志14g,毛冬青12g,石菖蒲18g,鸡血藤25g,豨莶草30g,威灵仙14g,川牛膝25g,加入5倍药材总重的水煎煮3小时,使用纱布过滤,保留滤液,滤渣再次加同样重量的水煎煮2小时,使用纱布过滤,合并两次煎煮的滤液,备用。
将上述药粉与合并后的滤液倒入剪切机中,5000转混合20分钟,将其混合均匀,再倒入烘干机中烘干,即得治疗中风后遗症的中药组合物。
实施例4
精确称取葛根19g,三七30g,土元10g,地龙42g,水蛭40g,乌梢蛇12g,粉碎至100目筛网筛余率不超过5%,备用。
精确称取黄芪160g,当归18g,川芎50g,赤芍10g,丹参12g,红花12g,桃仁9g,郁金16g,远志12g,毛冬青10g,石菖蒲20g,鸡血藤15g,豨莶草20g,威灵仙15g,川牛膝30g,加入5倍药材总重的水煎煮3小时,使用纱布过滤,保留滤液,滤渣再次加同样重量的水煎煮2小时,使用纱布过滤,合并两次煎煮的滤液,备用。
将上述药粉与合并后的滤液倒入剪切机中,5000转混合20分钟,将其混合均匀,再倒入烘干机中烘干,即得治疗中风后遗症的中药组合物。
实施例5
精确称取葛根20g,三七20g,土元8g,地龙35g,水蛭50g,乌梢蛇15g,粉碎至100目筛网筛余率不超过5%,备用。
精确称取黄芪140g,当归15g,川芎60g,赤芍11g,丹参18g,红花15g,桃仁15g,郁金12g,远志10g,毛冬青11g,石菖蒲17g,鸡血藤10g,豨莶草10g,威灵仙9g,川牛膝10g,加入5倍药材总重的水煎煮3小时,使用纱布过滤,保留滤液,滤渣再次加同样重量的水煎煮2小时,使用纱布过滤,合并两次煎煮的滤液,备用。
将上述药粉与合并后的滤液倒入剪切机中,5000转混合20分钟,将其混合均匀,再倒入烘干机中烘干,即得治疗中风后遗症的中药组合物。
实施例6
精确称取葛根18g,三七25g,土元12g,地龙45g,水蛭60g,乌梢蛇18g,粉碎至100目筛网筛余率不超过5%,备用。
精确称取黄芪180g,当归18g,川芎55g,赤芍25g,丹参16g,红花9g,桃仁9g,郁金15g,远志15g,毛冬青15g,石菖蒲20g,鸡血藤30g,豨莶草40g,威灵仙15g,川牛膝30g,加入5倍药材总重的水煎煮3小时,使用纱布过滤,保留滤液,滤渣再次加同样重量的水煎煮2小时,使用纱布过滤,合并两次煎煮的滤液,备用。
将上述药粉与合并后的滤液倒入剪切机中,5000转混合20分钟,将其混合均匀,再倒入烘干机中烘干,即得治疗中风后遗症的中药组合物。
将实施例1~6制得的中药组合物用于门诊中风病人的后遗症治疗,共26例,年龄在52岁~71岁之间,平均年龄61.7岁;其中男性17例,女性9例;脑梗患者19例,脑出血患者7例;病程3周~14个月,平均5个月;伴高血压6例,伴胸痹2例,伴糖尿病3例。
经治疗后,上述病例中治愈者18例,明显改善者6例,仅有2例未出现明显改善,有效率92.3%。
部分病例如下:
临床病例1:王某,男,63岁,脑梗后轻度偏瘫,有偏瘫步,无高血压、心脏病、糖尿病病史,服用实施例1中的中药组合物汤剂,经治疗4周后走路逐渐正常,治疗10周后,偏瘫症状消失。
临床病例2:张某,男,65岁,脑梗后出现口歪、流口水、言语不清症状,无高血压、心脏病、糖尿病病史,服用实施例2中的中药组合物汤剂,经治疗一周后吐字逐渐清晰,治疗4周后,言语清楚,流口水现象症状消失,口舌位置逐渐恢复,持续治疗6周后,口舌位置恢复正常。
临床病例3:胡某,女,71岁,脑梗后出现单侧下肢麻木、同侧上肢无力症状,无高血压、心脏病、糖尿病病史,服用实施例3中的中药组合物汤剂,经治疗2周后上肢无力症状改善,治疗4周后下肢麻木感减弱,治疗6周后上肢功能恢复,用药至12周,下肢基本无麻木感,恢复一定行走能力。
临床病例4:王某,男,61岁,脑梗后出现偏瘫症状,左侧上下肢麻木无力,无法自主行走,无高血压、心脏病、糖尿病病史,服用实施例3中的中药组合物汤剂,治疗2周后左侧上肢可略微抬起,治疗4周后,左侧上肢可做小幅抬起、伸展动作,麻木感消退,左侧下肢可小幅运动,但无法自主站起,治疗8周后,左侧上肢无力症状明显改善,下肢无力症状减轻,上下肢麻木感消失,可拄拐行走,持续治疗12周,可脱离工具辅助行走,但左侧肢体活动能力仍低于右侧,停药半年后复诊,症状未加重。
临床病例5:王某,男,67岁,脑梗后出现口歪眼斜、言语不清症状,伴心绞痛、胸部闷痛、气喘,服用实施例4中的中药组合物汤剂,治疗2周后言语不清症状改善,治疗4周后口歪眼斜症状明显改善,言语不清症状显著改善;此外,治疗1周后胸闷气喘症状发作频率降低,治疗2周后气喘症状消失,偶尔胸闷,其它治疗药物仅使用硝酸甘油。
临床病例6:张某,男,66岁,脑出血后出现半身不遂症状,单侧肢体麻木,伴高血压、心绞痛,服用实施例5中的中药组合物汤剂,治疗2周后肢体麻木症状改善,治疗4周后肢体麻木症状基本消失;此外,治疗1周后,心绞痛发作频次减少,治疗4周后心绞痛发作频次明显减少,持续治疗8周后,心绞痛极少发作,停药半年后复诊,心绞痛症状未加重,发作频次未出现明显上升,其它治疗药物仅使用硝酸甘油;此外,治疗过程中,高血压症状未明显改善。
临床病例7:刘某,女,69岁,脑梗后出现单侧下肢麻木,同侧上肢无力,伴糖尿病,服用实施例6中的中药组合物汤剂,治疗2周后上肢无力症状改善,下肢麻木感减轻,治疗6周后上肢无力症状基本消失,下肢麻木感明显改善,治疗12周后麻木无力症状消失;此外,治疗前后糖尿病症状未出现明显改善,血糖水平未明显下降。
上述病例表明,实施例3~6制得的中药组合物对脑梗、脑出血引起的半身不遂、偏瘫步、口歪眼斜、言语不清等症状均有明显的改善,治疗效果显著。
在临床治疗中发现,实施例4、5制备的中药组合物对胸痹症状也具有一定的治疗效果,经患者同意,使用实施例4制备的中药组合物对胸痹患者进行治疗,陆续实施了5例,均有不同程度的治疗效果。
病例1:男,64岁,症状心痛胸闷、咳痰黏稠;
病例2:男,65岁,症状胸闷气短,心悸乏力;
病例3:男,66岁,症状胸闷气短;
病例4:女,68岁,症状心悸气短、手足发冷;
病例5:男,59岁,症状胸痛、背痛、喘息不止。
上述病例治疗效果见下表:
表1胸痹病例治疗效果
上述5例病例中,病例5在服药2天后胸痛症状得到缓解,服药5天后背痛症状明显减轻,其它病例均在服药后5-8天见效,症状得到不同程度缓解。
经过上述5例病例验证,可以证明实施例4制备的中药组合物对胸痹症状具备明显治疗效果,由于实施例3~6所使用的药材种类一致、配比接近,可以合理推测实施例3~6制备的中药组合物均可用于胸痹症状的治疗,将其应用于门诊治疗后,截至目前共收治41名胸痹患者,共治愈27例,明显改善10例,仅有4例治疗效果未达到预期,治疗有效率为90.2%。
为方便服用,延长药剂的保存时间,对实施例3制备的中药组合物的剂型进行了调整,将制得的中药组合物倒入烘干机中烘干,制成粉剂,服用时使用热水冲服即可;还可将烘干后的药粉装入空胶囊中制成胶囊制剂,或制成丸剂、片剂、丸剂、丹剂、锭剂等剂型。
此外,在收治的中风后遗症患者中,1例在中风发作时摔倒导致股骨头骨折,经过手术治疗近1年后出现间歇性的髋部疼痛,在治疗前诊断为早期股骨头坏死(MRI-I期,),尚未进行针对性用药治疗。在门诊使用实施6制备的中药组合物治疗中风后遗症期间,持续用药5天后,髋部疼痛症状减轻,持续用药2周后,髋部疼痛的频次明显降低,疼痛程度明显减轻,持续用药8周后,髋部疼痛的症状基本消失,持续用药10周后,经MRI检查并对比治疗前MRI影像,负重区T1W线样低信号区基本消失,无双线征表现,可以确认股骨头坏死症状得到改善。
将实施例3~6制备的中药组合物用于门诊股骨头坏死患者治疗7例,均为外伤导致,其中I期5例,Ⅱ期2例,Ⅲ、Ⅳ期未收治,其中6例经过8~12周治疗后MRI复诊为0期,继续用药后达到治愈标准,剩余1例由Ⅱ期降为I期,后续通过其它治疗手段治愈。
以上所述仅为本发明的较佳实施例而已,并不用以限制本发明,凡在本发明的精神和原则之内所做的任何修改、等同替换和改进等,均应包含在本发明的保护范围之内。
Claims (10)
1.一种治疗中风后遗症的中药组合物,其特征在于,包括如下重量份的原料:
黄芪100-2000份,当归90-300份,川芎80-750份,
赤芍70-500份,丹参80-750份,红花50-250份,
桃仁50-250份,郁金80-750份,远志35-350份,
葛根80-300份,三七70-500份,土元80-750份,
地龙80-750份,水蛭90-800份,乌梢蛇65-700份,
毛冬青100-350份,石菖蒲70-500份,鸡血藤70-500份,
豨莶草100-400份,威灵仙80-750份,川牛膝70-500份。
2.根据权利要求1所述的一种治疗中风后遗症的中药组合物,其特征在于,包括如下重量份的原料:
黄芪1250-1800份,当归110-180份,川芎500-600份,
赤芍110-250份,丹参120-180份,红花90-150份,
桃仁90-150份,郁金120-200份,远志105-150份,
葛根180-200份,三七200-300份,土元80-120份,
地龙350-450份,水蛭300-600份,乌梢蛇95-180份,
毛冬青110-150份,石菖蒲170-200份,鸡血藤100-300份,
豨莶草100-400份,威灵仙90-150份,川牛膝100-300份。
3.根据权利要求2所述的一种治疗中风后遗症的中药组合物,其特征在于,由如下重量份的原料组成:
黄芪1350份,当归170份,川芎500份,
赤芍170份,丹参150份,红花110份,
桃仁120份,郁金150份,远志125份,
葛根180份,三七200份,土元100份,
地龙350份,水蛭400份,乌梢蛇150份,
毛冬青110份,石菖蒲170份,鸡血藤150份,
豨莶草180份,威灵仙120份,川牛膝220份。
4.根据权利要求1-3任一所述的中药组合物的制备方法,其特征在于,包括如下步骤:
S1:将葛根、三七、土元、地龙、水蛭、乌梢蛇粉碎成1mm以下的药粉;
S2:将剩余药材水煎1次,分离出滤液;
S3:取步骤S2分离出的药渣,再次水煎1次,分离出滤液并与S2的滤液合并;
S4:将步骤S3合并后的滤液与S1制得的药粉混合均匀,烘干,即得。
5.根据权利要求4所述的中药组合物的制备方法,其特征在于,步骤S1中,将葛根、三七、土元、地龙、水蛭、乌梢蛇粉碎,粉碎后的药粉100目筛网筛余率不超过5%。
6.根据权利要求4或5所述的中药组合物的制备方法,其特征在于,还包括如下步骤:将步骤S4得到的中药组合物制成口服剂型。
7.根据权利要求6所述的中药组合物的制备方法,其特征在于,所述剂型包括丸剂、片剂、胶囊、散剂、丸剂、丹剂、锭剂。
8.权利要求1-3任一所述的中药组合物在制备治疗中风后遗症药物中的应用。
9.权利要求1-3任一所述的中药组合物在制备治疗胸痹药物中的应用。
10.权利要求1-3任一所述的中药组合物在制备治疗股骨头坏死药物中的应用。
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