CN115486448A - Low-temperature disinfectant for inactivating SARS-CoV-2 virus at-80 DEG C - Google Patents
Low-temperature disinfectant for inactivating SARS-CoV-2 virus at-80 DEG C Download PDFInfo
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- CN115486448A CN115486448A CN202211139434.0A CN202211139434A CN115486448A CN 115486448 A CN115486448 A CN 115486448A CN 202211139434 A CN202211139434 A CN 202211139434A CN 115486448 A CN115486448 A CN 115486448A
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- 239000000645 desinfectant Substances 0.000 title claims abstract description 56
- 230000000415 inactivating effect Effects 0.000 title abstract description 5
- 241001678559 COVID-19 virus Species 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 56
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 51
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims abstract description 46
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000007788 liquid Substances 0.000 claims abstract description 11
- 235000019441 ethanol Nutrition 0.000 claims description 18
- 230000000249 desinfective effect Effects 0.000 claims description 14
- 230000001954 sterilising effect Effects 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 10
- 208000001528 Coronaviridae Infections Diseases 0.000 claims description 2
- 230000002708 enhancing effect Effects 0.000 claims description 2
- 239000007921 spray Substances 0.000 claims description 2
- 241000700605 Viruses Species 0.000 abstract description 13
- 241000711573 Coronaviridae Species 0.000 abstract description 11
- 235000013305 food Nutrition 0.000 abstract description 5
- 241000894006 Bacteria Species 0.000 abstract description 2
- 230000000694 effects Effects 0.000 description 21
- 230000000052 comparative effect Effects 0.000 description 13
- 230000002147 killing effect Effects 0.000 description 8
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 239000007798 antifreeze agent Substances 0.000 description 3
- 230000015271 coagulation Effects 0.000 description 3
- 238000005345 coagulation Methods 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 241000701161 unidentified adenovirus Species 0.000 description 3
- 241000700584 Simplexvirus Species 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000002528 anti-freeze Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 239000005708 Sodium hypochlorite Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 235000013611 frozen food Nutrition 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical group [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 210000003501 vero cell Anatomy 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/22—Phase substances, e.g. smokes, aerosols or sprayed or atomised substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2101/00—Chemical composition of materials used in disinfecting, sterilising or deodorising
- A61L2101/32—Organic compounds
- A61L2101/34—Hydroxy compounds
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Environmental Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Agronomy & Crop Science (AREA)
- Dentistry (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to the technical field of low-temperature disinfection, and particularly provides a low-temperature disinfection solution at-80 ℃ for inactivating SARS-CoV-2 virus. The low-temperature disinfectant at the temperature of-80 ℃ comprises: absolute ethyl alcohol, isopropyl alcohol and water. The low-temperature disinfectant provided by the invention has simple components and is harmless to human bodies and food, and the low-temperature disinfectant can keep a liquid state at-80 ℃. The low-temperature disinfectant liquid at minus 80 ℃ provided by the invention can effectively kill viruses and bacteria on the surface of an object under the environment of minus 80 ℃ and above, including novel coronavirus (SARS-CoV-2).
Description
Technical Field
The invention relates to the technical field of low-temperature disinfection, in particular to a low-temperature disinfection solution at-80 ℃ for inactivating SARS-CoV-2 virus.
Background
The low-temperature environment of the cold chain food provides a good survival space for the virus, and the surface of the frozen food and the ambient temperature of the cold storage are low, so that the cold chain food is suitable for the long-term survival of the virus.
The current low-temperature disinfection methods comprise an irradiation disinfection technology, an ultrahigh-pressure disinfection technology and the like. The former seems not to be harmful to human body in principle, but how the ray changes the internal structure of the food has no potential risk, and the method is yet to be observed and experimentally verified. The ultra-high pressure sterilization technology has proved to have good low-temperature sterilization effect, but the sterilization effect below zero degree needs to be examined urgently. In addition, the manufacture of the ultra-high pressure sterilization apparatus is also a difficulty.
The main component of the 84 disinfectant commonly used in the prior art is sodium hypochlorite which is mainly used at normal temperature. When the temperature of the conventional 84 disinfectant is lower than zero, the disinfectant can be frozen and solidified, and the sterilization and disinfection effects cannot be exerted. In general, additives such as an antifreeze are added to a normal temperature disinfectant to achieve a disinfection effect below zero.
However, when the low temperature is ultra-low temperature of-80 ℃, the low temperature disinfectants in the market, such as disinfectants at-18 ℃, 20 ℃ and 40 ℃ below zero, can not achieve good disinfection effect. In the prior art, no disinfectant liquid is available in a low-temperature environment of minus 80 ℃. There is no good sterilization technique for the surface of the article stored and preserved at a temperature of-80 ℃.
Disclosure of Invention
The invention makes up the blank of low-temperature disinfectant liquid at minus 80 ℃ in the prior art and provides the low-temperature disinfectant liquid at minus 80 ℃ for inactivating SARS-CoV-2 virus.
The disinfectant provided by the invention comprises: absolute ethyl alcohol, isopropyl alcohol and water.
In the disinfectant provided by the invention, the water accounts for 25-35% of the disinfectant in terms of volume ratio.
In the disinfectant provided by the invention, the absolute ethyl alcohol accounts for 45-55% of the disinfectant in terms of volume ratio.
In the disinfectant provided by the invention, the isopropanol accounts for 15-25% of the disinfectant by volume ratio.
In the disinfectant provided by the invention, the ratio of the ethanol to the isopropanol to the water is (45-55) to (15-25) to (25-30) in terms of volume ratio.
According to the understanding of the technical personnel in the field, the invention also claims the application of the disinfection solution in enhancing the disinfection and sterilization efficiency in low-temperature environment.
And the application of the disinfectant in preventing the novel coronavirus infection in low-temperature cold chain transportation.
In the prior art, an antifreeze or other additives are usually added in the conventional disinfectant to achieve the liquid state below zero degree. However, the invention discovers that when the temperature is reduced to minus 80 ℃, if the phenomenon of the solidification of the disinfectant is eliminated by adding the antifreeze agent, a large amount of antifreeze agent is needed, and the addition of the antifreeze agent seriously reduces the sterilization and disinfection effects of the disinfectant at minus 80 ℃.
In long-term research and trial, the invention unexpectedly discovers that when the ratio of ethanol, isopropanol and water is (45-55): (15-25): (25-30), the liquid state can be presented at minus 80 ℃, and the invention has good sterilization and disinfection effects.
Ethanol is a recognized product with a quick disinfection effect and is usually used in a normal temperature environment. When used in a low-temperature or ultra-low-temperature environment, not only the sterilization effect but also the low-temperature or ultra-low-temperature environment need to be considered. After the proper ethanol and the isopropanol are mixed according to a certain proportion, the freezing point of the disinfectant can be obviously reduced, the dosage of the ethanol is reduced on the premise of having the same disinfection effect, and the disinfection action time can be prolonged
The invention also provides a method for disinfecting the environment at the low temperature of minus 80 ℃, and the disinfectant is used for carrying out spray disinfection on the environment at the low temperature of minus 80 ℃.
In the method provided by the invention, the ratio of the consumption of the disinfectant to the area of the low-temperature environment to be disinfected is 1L:150-200m 2 。
Pathogenic microorganisms such as viruses are relatively resistant to low-temperature environments, and disinfection solutions capable of disinfecting articles in low-temperature environments are needed, such as cold chain transportation, cold storage warehouses and the like.
The invention has the beneficial effects that:
(1) The low-temperature disinfection solution provided by the invention has simple components and is harmless to human bodies and food, and the low-temperature disinfection solution provided by the invention can keep a liquid state at-80 ℃.
(2) The low-temperature disinfectant liquid at minus 80 ℃ provided by the invention can effectively kill viruses and bacteria on the surface of an object under the environment of minus 80 ℃ and above, including novel coronavirus (SARS-CoV-2).
Detailed Description
To make the objects, technical solutions and advantages of the present invention clearer and more complete, the technical solutions of the present invention will be described below clearly, and it is obvious that the described embodiments are some, not all embodiments of the present invention. All other embodiments, which can be obtained by a person skilled in the art without inventive step based on the embodiments of the present invention, are within the scope of protection of the present invention.
Example 1
The embodiment provides a low-temperature disinfectant at-80 ℃, and the formula and the preparation method comprise the following steps: 55% of ethanol, 20% of isopropanol and 25% of water, and uniformly mixing.
Example 2
The embodiment provides a low-temperature disinfectant at-80 ℃, and the formula and the preparation method thereof are as follows: 45% of ethanol, 25% of isopropanol and 30% of water are uniformly mixed.
Example 3
The embodiment provides a low-temperature disinfectant at-80 ℃, and the formula and the preparation method thereof are as follows: 50% of ethanol, 20% of isopropanol and 30% of water are uniformly mixed.
Experimental example 1 optimum temperature detection of Low-temperature disinfectant
In this experimental example, the disinfection effects of the low-temperature disinfection solutions obtained in examples 1 to 3 at different temperatures were tested, and specifically, in this experimental example, the coagulation degrees of the disinfection solutions and the sterilization and disinfection effects of the disinfection solutions at different temperatures were tested, as shown in tables 1 and 2.
TABLE 1 degree of coagulation of the low-temperature sterilizing fluids of examples 1 to 3
| Degree of coagulation | Example 1 | Example 2 | Example 3 |
| At room temperature | Does not solidify | Does not solidify | Does not solidify |
| -4℃ | Does not solidify | Does not solidify | Does not solidify |
| -20℃ | Does not solidify | Does not solidify | Does not solidify |
| -40℃ | Does not solidify | Does not solidify | Does not solidify |
| -60℃ | Does not solidify | Does not solidify | Does not solidify |
| -80℃ | Does not solidify | Does not solidify | Does not solidify |
TABLE 2 Sterilization and Disinfection effects of the Low-temperature Disinfection solutions of examples 1 to 3
| Sterilizing and disinfecting | Example 1 | Example 2 | Example 3 |
| At normal temperature | Is effective | Is effective | Is effective |
| -4℃ | Is effective | Is effective | Is effective |
| -20℃ | Is effective | Is effective | Is effective |
| -40℃ | Is effective | Is effective | Is effective |
| -60℃ | Is effective | Is effective | Is effective |
| -80℃ | Is effective | Is effective | Is effective |
The results show that the disinfectant obtained in the embodiment of the invention has the best disinfection and sterilization effect at normal temperature to-80 ℃.
Experimental example 2 killing effect of low-temperature disinfectant on different viruses
This experimental example evaluates the killing effect of the low temperature disinfection solution of-80 ℃ obtained in example 1 on different viruses, and three viruses were selected for experiments, namely, a novel coronavirus (SARS-CoV-2), adenovirus and herpes simplex virus. The sensitive cells used by the virus are Vero, hep-2 and Vero cells.
The new coronavirus used has a titre of 10 5.39 TCID50/0.1ml; the adenovirus titer used was 10 7.74 TCID50/0.1ml; herpesvirus titre of 10 6.33 TCID50/0.1ml, the results are shown in tables 3, 4 and 5.
TABLE 3 Effect of low temperature disinfection solution on killing new type coronavirus at-80 deg.C in refrigerator
TABLE 4 Effect of low-temperature disinfectant on adenovirus at-80 deg.C in refrigerator
TABLE 5 Effect of low temperature disinfectant on herpes simplex virus at-80 deg.C in refrigerator
In the table X represents cell death; + represents a lesion in the cell; -represents normal growth of cells
Comparative example 1 different alcohols
The low-temperature disinfection solution provided by the comparative example is different from the low-temperature disinfection solution A provided by the example 1 in that ethylene glycol is used for replacing isopropanol.
The low-temperature disinfectant obtained in example 1 was used as C, and the effect of the two low-temperature disinfectants on killing novel coronaviruses at-80 ℃ in a refrigerator was examined by the same method as in experimental example 2, and is shown in table 6.
TABLE 6 killing effect of low-temperature disinfectant on novel coronavirus at-80 deg.C in refrigerator
The results of this comparative example demonstrate that only isopropanol acts synergistically with ethanol.
Comparative example 2 different ratio of ethanol to isopropanol
The low-temperature disinfection solution provided by the comparative example is different from the low-temperature disinfection solution provided by the example 1 in that in the low-temperature disinfection solution D of the comparative example, ethanol accounts for 40% of the low-temperature disinfection solution, isopropanol accounts for 30% of the low-temperature disinfection solution, and the ratio of the ethanol to the isopropanol is 40; in the low-temperature disinfection solution E, ethanol accounts for 25% of the low-temperature disinfection solution, isopropanol accounts for 45% of the low-temperature disinfection solution, and the ratio of the ethanol to the isopropanol is 25.
The low-temperature disinfectant obtained in example 1 was used as C, and the same method as in experimental example 2 was used to test the effect of the three low-temperature disinfectants on killing novel coronavirus at-80 ℃ in a refrigerator, as shown in table 7.
TABLE 7 Effect of low-temperature sterilizing liquid at-80 deg.C in refrigerator on killing novel coronavirus
The results of this comparative example demonstrate that ethanol and isopropanol act synergistically only at the appropriate ratio.
Comparative example 3 disinfectant with different water content
The comparative example provides a low-temperature disinfectant, and in the low-temperature disinfectant F of the comparative example, water accounts for 40-45% of the low-temperature disinfectant; in the low-temperature disinfectant G of the comparative example, water accounts for 35-40% of the low-temperature disinfectant.
The low-temperature disinfectant obtained in example 1 was used as C, and the same method as in example 2 was used to examine the effect of three low-temperature disinfectants on the novel coronavirus at-80 ℃ in a refrigerator, as shown in table 8.
TABLE 8 killing effect of low-temperature disinfectant on novel coronavirus at-80 deg.C in refrigerator
The results of this comparative example and comparative example 2 confirm that the synergistic effect can only be achieved by using appropriate water, water in the low-temperature disinfectant, ethanol and isopropanol.
Finally, it should be noted that: the above examples are only intended to illustrate the technical solution of the present invention, and not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.
Claims (10)
1. A disinfecting solution, comprising: absolute ethyl alcohol, isopropyl alcohol and water.
2. The disinfecting solution of claim 1, wherein the water comprises 25-35% of the disinfecting solution by volume.
3. The disinfecting solution of claim 1, wherein the absolute ethanol is 45-55% by volume of the disinfecting solution.
4. The disinfecting solution of claim 1, wherein the isopropyl alcohol is 15-25% by volume of the disinfecting solution.
5. The disinfecting solution of claim 1, wherein the ratio of ethanol, isopropanol and water is (45-55): (15-25): (25-35) by volume ratio.
6. The use of the disinfecting solution of any one of claims 1 to 5 for enhancing the disinfecting and sterilizing efficiency in a low-temperature environment.
7. Use of the disinfectant liquid according to any one of claims 1 to 5 for preventing a novel coronavirus infection in cold chain transportation at low temperature.
8. Use according to any one of claims 6 to 7, wherein the low temperature is from-4 ℃ to-80 ℃.
9. A method for disinfection in a low-temperature environment at-80 ℃, which is characterized in that the disinfectant of any one of claims 1 to 5 is used for spray disinfection in a low-temperature environment at-80 ℃.
10. The method of claim 9, wherein the ratio of the amount of the disinfecting solution to the area of the low-temperature environment to be disinfected is 1L:150-200m 2 。
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113133462A (en) * | 2021-04-28 | 2021-07-20 | 李俊 | Chlorine-containing disinfectant in low-temperature environment and preparation method thereof |
| CN113439741A (en) * | 2021-08-05 | 2021-09-28 | 湖北省农业科学院中药材研究所 | Preparation method of primary color soaked specimen of snake mushroom |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113133462A (en) * | 2021-04-28 | 2021-07-20 | 李俊 | Chlorine-containing disinfectant in low-temperature environment and preparation method thereof |
| CN113439741A (en) * | 2021-08-05 | 2021-09-28 | 湖北省农业科学院中药材研究所 | Preparation method of primary color soaked specimen of snake mushroom |
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