CN115484920A - 实现良好产品稠度和性能的具有非乙氧基化表面活性剂和辅助表面活性剂的组合物 - Google Patents
实现良好产品稠度和性能的具有非乙氧基化表面活性剂和辅助表面活性剂的组合物 Download PDFInfo
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- CN115484920A CN115484920A CN202180033473.XA CN202180033473A CN115484920A CN 115484920 A CN115484920 A CN 115484920A CN 202180033473 A CN202180033473 A CN 202180033473A CN 115484920 A CN115484920 A CN 115484920A
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- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
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Abstract
本发明涉及一种个人护理组合物,所述个人护理组合物包含:约6%至约15%的月桂基硫酸钠;约0.63:1至约15:1的月桂基硫酸钠与辅助表面活性剂的比率;约10%至约20%的总表面活性剂;并且具有约3000cps至约20,000cps的粘度,并且其中所述个人护理组合物包含小于约2%的月桂基聚氧乙烯醚硫酸钠。
Description
技术领域
本发明涉及非乙氧基化表面活性剂和辅助表面活性剂的组合,其实现产品粘度、维持期望的泡沫特征、以及沉积毛发/头皮活性物质。
背景技术
乙氧基化表面活性剂诸如月桂基聚氧乙烯醚硫酸钠在美容行业广泛用于个人清洁产品中。这些表面活性剂传统上已经用于实现消费者期望的产品特征,包括手中粘度/产品质地、泡沫、清洁、以及头皮/头皮活性物质的沉积。
为了满足客户和零售商对乙氧基化游离表面活性剂不断变化的需求,有必要为利用非乙氧基化表面活性剂的洗发剂产品开发替代配制办法,而不存在消费者明显的负面权衡。
利用非乙氧基化表面活性剂和辅助表面活性剂的组合在实现产品粘度、维持期望的泡沫特征、以及沉积毛发/头皮活性物质中形成挑战。
发明内容
本发明涉及一种个人护理组合物,所述个人护理组合物包含:约6%至约15%的月桂基硫酸钠;约0.63:1至约15:1的月桂基硫酸钠与辅助表面活性剂的比率;约10%至约20%的总表面活性剂;并且具有约3000cps至约20,000cps的粘度,并且其中所述个人护理组合物包含小于约2%的月桂基聚氧乙烯醚硫酸钠。
具体实施方式
除非另外指明,否则本文中使用的所有百分比和比率均按总组合物的重量计。除非另外指明,所有测量均被理解为是在环境条件下进行,其中“环境条件”是指在约25℃下,在约一个大气压下,并且在约50%相对湿度下的条件。所有数值范围是包括端值在内的更窄的范围;所描述的范围上限和下限是可组合的,以形成没有明确描述的另外的范围。
本发明的组合物可包含本文所述的基本组分以及任选的成分,基本上由其组成或由其组成。如本文所用,“基本上由...组成”是指组合物或组分可包含附加成分,只要附加成分不在本质上改变受权利要求书保护的组合物或方法的基本特征和新颖特征。
如关于组合物所用的“施加”或“施用”是指将本发明的组合物施加或铺展到角质组织诸如毛发上。
“皮肤病学可接受的”是指所述组合物或组分适用于与人的皮肤组织接触,而没有不适当的毒性、不相容性、不稳定性、变应性应答等。
“安全且有效的量”是指足以显著地诱导积极有益效果的化合物或组合物的量。
虽然本说明书以特别指出并清楚地要求保护本发明的权利要求书作为结尾,但据信通过下列说明可更好地理解本发明。
如本文所用,术语“流体”包括液体和凝胶。
如本文所用,当用于权利要求中时,包括“一个”和“一种”的冠词应被理解为是指一种或多种受权利要求书保护或所描述的物质。
如本文所用,“包括/包含”是指可加入不影响最终结果的其它步骤和其它成分。该术语涵盖术语“由……组成”和“基本上由……组成”。
如本文所用,“混合物”旨在包括物质的简单组合以及由它们的组合所可能产生的任何化合物。
如本文所用,除非另外指明,否则“分子量”是指重均分子量。分子量使用工业标准方法、凝胶渗透色谱法(“GPC”)测量。
在给定含量范围的情况下,这些应当被理解为组合物中所述成分的总量,或在多于一种物质落入成分定义的范围内的情况下,组合物中所有成分的总量符合所述定义。
例如,如果组合物包含1%至5%的脂肪醇,则包含2%硬脂醇和1%鲸蜡醇并且没有其它脂肪醇的组合物将落入该范围内。
下文描述的每种特定成分或它们的混合物的量可占个人护理组合物中成分总量的至多100%(或100%)。
如本文所用,“个人护理组合物”包括诸如洗发剂、沐浴凝胶、液体手清洁剂、毛发着色剂、面部清洁剂和其它基于表面活性剂的液体组合物。
如本文所用,术语“包括”、“包含”和“含有”旨在是非限制性的,并且理解为分别是指“具有”、“具备”和“涵盖”。
除非另外说明,否则所有百分比、份数和比率均基于本发明的组合物的总重量。所有涉及所列成分的这些重量均基于活性物质的含量,并且因此不包括可能包含在可商购获得的物质中的载体或副产物。
除非另外指明,否则所有组分或组合物水平均是就该组分或组合物的活性部分而言,且不包括可能存在于此类组分或组合物的可商购获得的来源中的杂质,例如残余溶剂或副产物。
应当理解,贯穿本说明书给出的每一最大数值限度包括每一较低数值限度,如同此类较低数值限度在本文中明确写出。贯穿本说明书给出的每一最小数值限度将包括每一较高数值限度,如同此类较高数值限度在本文中明确写出。贯穿本说明书给出的每一数值范围将包括落在此类较宽数值范围内的每一较窄数值范围,如同此类较窄的数值范围全部在本文中明确写出。
去污表面活性剂
个人护理组合物可包含大于约10重量%的向组合物提供清洁性能的表面活性剂体系,并且可以是大于12重量%的向组合物提供清洁性能的表面活性剂体系。表面活性剂体系包含阴离子表面活性剂和/或阴离子表面活性剂的组合和/或阴离子表面活性剂与选自由两性、两性离子、非离子以及它们的混合物组成的组的辅助表面活性剂的组合。去污表面活性剂的各种示例和描述示于美国专利8,440,605;美国专利申请公布2009/155383;和美国专利申请公布2009/0221463中,这些文献全文以引用方式并入本文。
个人护理组合物可包含约10重量%至约25重量%、约10重量%至约18重量%、约10重量%至约14重量%、约10重量%至约12重量%、约11重量%至约20重量%、约12重量%至约20重量%、和/或约12重量%至约18重量%的一种或多种表面活性剂。
适用于组合物中的阴离子表面活性剂为烷基硫酸盐和烷基醚硫酸盐。其它合适的阴离子表面活性剂为有机硫酸反应产物的水溶性盐。其它合适的阴离子表面活性剂为用羟乙磺酸酯化并且用氢氧化钠中和的脂肪酸的反应产物。其它类似的阴离子表面活性剂描述于美国专利2,486,921;2,486,922;和2,396,278中,这些文献全文以引用方式并入本文。
用于个人护理组合物中的示例性阴离子表面活性剂包括月桂基硫酸铵、月桂基聚氧乙烯醚硫酸铵、C10-15烷基聚氧乙烯醚硫酸铵、C10-15烷基硫酸铵、C11-15烷基硫酸铵、癸基硫酸铵、癸基聚氧乙烯醚硫酸铵、十一烷基硫酸铵、十一烷基聚氧乙烯醚硫酸铵、月桂基硫酸三乙胺、月桂基聚氧乙烯醚硫酸三乙胺、月桂基硫酸三乙醇胺、月桂基聚氧乙烯醚硫酸三乙醇胺、月桂基硫酸单乙醇胺、月桂基聚氧乙烯醚硫酸单乙醇胺、月桂基硫酸二乙醇胺、月桂基聚氧乙烯醚硫酸二乙醇胺、月桂酸单甘油酯硫酸钠、月桂基硫酸钠、月桂基聚氧乙烯醚硫酸钠、C10-15烷基聚氧乙烯醚硫酸钠、C10-15烷基硫酸钠、C11-15烷基硫酸钠、癸基硫酸钠、癸基聚氧乙烯醚硫酸钠、十一烷基硫酸钠、十一烷基聚氧乙烯醚硫酸钠、月桂基硫酸钾、月桂基聚氧乙烯醚硫酸钾、C10-15烷基聚氧乙烯醚硫酸钾、C10-15烷基硫酸钾、C11-15烷基硫酸钾、癸基硫酸钾、癸基聚氧乙烯醚硫酸钾、十一烷基硫酸钾、十一烷基聚氧乙烯醚硫酸钾、月桂基肌氨酸钠、月桂酰肌氨酸钠、月桂基肌氨酸、椰油基肌氨酸、椰油基硫酸铵、月桂酰硫酸铵、椰油基硫酸钠、月桂酰硫酸钠、椰油基硫酸钾、月桂基硫酸钾、月桂基硫酸三乙醇胺、月桂基硫酸三乙醇胺、椰油基硫酸单乙醇胺、月桂基硫酸单乙醇胺、十三烷基苯磺酸钠、十二烷基苯磺酸钠、椰油基羟乙基磺酸钠、以及它们的组合。阴离子表面活性剂可为月桂基硫酸钠或月桂基聚氧乙烯醚硫酸钠。
本发明的组合物还可包含选自以下的阴离子表面活性剂:
a)R1O(CH2CHR3O)ySO3M;
b)CH3(CH2)zCHR2CH2O(CH2CHR3O)ySO3M;和
c)它们的混合物,
其中R1表示CH3(CH2)10,R2表示H或烃基团,该烃基团包含1至4个碳原子,使得z和R2中碳原子之和为8,R3为H或CH3,y为0至7,当y不为零(0)时,y的平均值为约1,并且M为一价或二价带正电荷的阳离子。
适宜的阴离子烷基硫酸盐和烷基醚硫酸盐表面活性剂包括但不限于具有支链烷基链的那些,其由可选自以下的C8至C18支链醇合成:格尔伯特醇、羟醛缩合衍生的醇、羰基合成醇、F-T羰基合成醇、以及它们的混合物。2-烷基支链醇的非限制性示例包括:羰基合成醇,诸如2-甲基-1-十一烷醇,2-乙基-1-癸醇,2-丙基-1-壬醇,2-丁基-1-辛醇,2-甲基-1-十二烷醇,2-乙基-1-十一烷醇,2-丙基-1-癸醇,2-丁基-1-壬醇,2-戊基-1-辛醇,2-戊基-1-庚醇,以及以下列商品名出售的那些:(Sasol)、(Sasol)、和(Shell);以及Guerbet和羟醛缩合衍生的醇,诸如2-乙基-1-己醇,2-丙基-1-丁醇,2-丁基-1-辛醇,2-丁基-1-癸醇,2-戊基-1-壬醇,2-己基-1-辛醇,2-己基-1-癸醇和以商品名称(Sasol)出售的那些或作为醇乙氧基化物和烷氧基化物以商品名LUTENSOL(BASF)和LUTENSOL(BASF)出售的那些。
阴离子烷基硫酸盐和烷基醚硫酸盐还可包括由衍生自丁烯或丙烯的C8至C18支链醇合成的那些,其以商品名EXXALTM(Exxon)和(Sasol)出售。这包括十三烷基聚氧乙烯醚-n硫酸钠(STnS)的亚型的阴离子表面活性剂,其中n介于约0.5和约3.5之间。该亚型的示例性表面活性剂是十三烷基聚氧乙烯醚-2硫酸钠和十三烷基聚氧乙烯醚-3硫酸钠。本发明的组合物还可包含十三烷基硫酸钠。
本发明的组合物还可包括阴离子烷基和烷基醚磺基琥珀酸盐和/或二烷基和二烷基醚磺基琥珀酸盐以及它们的混合物二烷基和二烷基醚磺基琥珀酸盐可以为C6-15直链或支链的二烷基或二烷基醚磺基琥珀酸盐。烷基部分可以是对称的(即,相同的烷基部分)或不对称的(即,不同的烷基部分)。非限制性示例包括:月桂基磺基琥珀酸二钠、月桂基聚氧乙烯醚磺基琥珀酸二钠、双十三烷基磺基琥珀酸钠、二辛基磺基琥珀酸钠、二己基磺基琥珀酸钠、二环己基磺基琥珀酸钠、二戊基磺基琥珀酸钠、二异丁基磺基琥珀酸钠、直链双(十三烷基)磺基琥珀酸盐以及它们的混合物。
个人护理组合物可包含辅助表面活性剂。辅助表面活性剂可选自两性表面活性剂、两性离子表面活性剂、非离子表面活性剂、以及它们的混合物。辅助表面活性剂可包括但不限于月桂酰胺基丙基甜菜碱、椰油酰胺基丙基甜菜碱、月桂基羟基磺基甜菜碱、月桂酰两性基乙酸钠、椰油酰两性基二乙酸二钠、椰酰胺单乙醇酰胺、以及它们的混合物。
个人护理组合物可包含约6%至约15%的月桂基硫酸钠;个人护理组合物可包含约12%至约15%。
个人护理组合物可包含小于约2%的月桂基聚氧乙烯醚硫酸钠;个人护理组合物可包含小于约1%的月桂基聚氧乙烯醚硫酸钠;个人护理组合物可包含小于约0.5%的月桂基聚氧乙烯醚硫酸钠;个人护理组合物可包含0%的月桂基聚氧乙烯醚硫酸钠。
个人护理组合物还可包含约0.25重量%至约15重量%,约1重量%至约14重量%,约2重量%至约13重量%的一种或多种两性、两性离子、非离子辅助表面活性剂、或它们的混合物。
个人护理组合物可包含约10%至约20%的总表面活性剂;个人护理组合物可包含约12%至约15%的总表面活性剂。
个人护理组合物可包含约0.63:1至约15:1的月桂基硫酸钠与辅助表面活性剂的比率;个人护理组合物可包含约0.63:1至约14:1的月桂基硫酸钠与辅助表面活性剂的比率;个人护理组合物可包含约3:1至约13:1的月桂基硫酸钠与辅助表面活性剂的比率;个人护理组合物可包含约10:1至约13:1的月桂基硫酸钠与辅助表面活性剂的比率。
用于本文个人护理组合物中的合适的两性表面活性剂或两性离子表面活性剂包括已知用于洗发剂或其他个人护理清洁的那些。合适的两性离子表面活性剂或两性表面活性剂的非限制性示例描述于美国专利5,104,646和5,106,609中,这些文献全文以引用方式并入本文。
适用于组合物中的两性辅助表面活性剂包括被描述为脂族仲胺和叔胺的衍生物的那些表面活性剂,其中脂族基团可为直链或支链,并且其中脂族取代基中的一个含有约8至约18个碳原子,并且一个脂族取代基含有阴离子基团,诸如羧基、磺酸根、硫酸根、磷酸根或膦酸根。合适的两性表面活性剂包括但不限于选自以下的那些:椰油氨基丙酸钠、椰油氨基二丙酸钠、椰油酰两性基乙酸钠、椰油酰两性基二乙酸钠、椰油酰两性基羟丙基磺酸钠、椰油酰两性基丙酸钠、玉米油酰两性基丙酸钠、月桂氨基丙酸钠、月桂酰两性基乙酸钠、月桂酰两性基二乙酸钠、月桂酰两性基羟丙基磺酸钠、月桂酰两性基丙酸钠、玉米油酰两性基丙酸钠、月桂亚氨基二丙酸钠、椰油氨基丙酸铵、椰油氨基二丙酸铵、椰油酰两性基乙酸铵、椰油酰两性基二乙酸铵、椰油酰两性基羟丙基磺酸铵、椰油酰两性基丙酸铵、玉米油酰两性基丙酸铵、月桂氨基丙酸铵、月桂酰两性基乙酸铵、月桂酰两性基二乙酸铵、月桂酰两性基羟丙基磺酸铵、月桂酰两性基丙酸铵、玉米油酰两性基丙酸铵、月桂亚氨基二丙酸铵、椰油氨基丙酸三乙醇胺、椰油氨基二丙酸三乙醇胺、椰油酰两性基乙酸三乙醇胺、椰油酰两性基羟丙基磺酸三乙醇胺、椰油酰两性基丙酸三乙醇胺、玉米油酰两性基丙酸三乙醇胺、月桂氨基丙酸三乙醇胺、月桂酰两性基乙酸三乙醇胺、月桂酰两性基羟丙基磺酸三乙醇胺、月桂酰两性基丙酸三乙醇胺、玉米油酰两性基丙酸三乙醇胺、月桂亚氨基二丙酸三乙醇胺、椰油酰两性基二丙酸、癸酰两性基二乙酸二钠、癸酰两性基二丙酸二钠、辛酰两性基二乙酸二钠、辛酰两性基二丙酸二钠、椰油酰两性基羧乙基羟丙基磺酸二钠、椰油酰两性基二乙酸二钠、椰油酰两性基二丙酸二钠、二羧乙基椰油基丙二胺二钠、月桂基聚氧乙烯醚-5羧基两性基二乙酸二钠、月桂亚氨基二丙酸二钠、月桂酰两性基二乙酸二钠、月桂酰两性基二丙酸二钠、油基两性基二丙酸二钠、PPG-2-异癸醇聚醚-7羧基两性基二乙酸二钠、月桂氨基丙酸、月桂酰两性基二丙酸、月桂基氨基丙基甘氨酸、月桂基二亚乙基二氨基甘氨酸、以及它们的混合物。
组合物可包含两性离子辅助表面活性剂,其中两性离子表面活性剂为脂族季铵、鏻和锍化合物的衍生物,其中脂族基团可为直链或支链,并且其中脂族取代基中的一个含有约8至约18个碳原子,并且一个脂族取代基含有阴离子基团,诸如羧基、磺酸根、硫酸根、磷酸根或膦酸根。两性离子表面活性剂可选自由以下组成的组:椰油酰胺基乙基甜菜碱、椰油酰胺基丙基氧化胺、椰油酰胺基丙基甜菜碱、椰油酰胺基丙基二甲基氨基羟丙基水解胶原、椰油酰胺基丙基二甲基铵羟丙基水解胶原、椰油酰胺基丙基羟基磺基甜菜碱、椰油甜菜碱酰胺基两性基丙酸盐、椰油基甜菜碱、椰油基羟基磺基甜菜碱、椰油基/油基酰胺基丙基甜菜碱、椰油基磺基甜菜碱、月桂酰胺基丙基甜菜碱、月桂基甜菜碱、月桂基羟基磺基甜菜碱、月桂基磺基甜菜碱、以及它们的混合物。
适用于本发明中的非离子表面活性剂包括McCutcheion的“Detergents andEmulsifiers”北美版(1986年,Allured Publishing Corp.)和McCutcheion的“FunctionalMaterials”北美版(1992)中描述的那些。适用于本发明个人护理组合物的非离子表面活性剂包括但不限于聚氧乙烯化烷基酚、聚氧乙烯化醇、聚氧乙烯化聚丙二醇、链烷酸的甘油酯、链烷酸的聚甘油酯、链烷酸的丙二醇酯、链烷酸的山梨醇酯、链烷酸的聚氧乙烯化山梨醇酯、链烷酸的聚氧乙二醇酯、聚氧乙烯化链烷酸、链烷醇酰胺、N-烷基吡咯烷酮、烷基糖苷、烷基多葡糖苷、烷基胺氧化物、和聚氧乙烯化硅氧烷。
辅助表面活性剂可以为非离子表面活性剂,该非离子表面活性剂选自:椰油酰胺、椰油酰胺甲基MEA、椰油酰胺DEA、椰油酰胺MEA、椰油酰胺MIPA、月桂酰胺DEA、月桂酰胺MEA、月桂酰胺MIPA、十四酰胺DEA、十四酰胺MEA、PEG-20椰油酰胺MEA、PEG-2椰油酰胺、PEG-3椰油酰胺、PEG-4椰油酰胺、PEG-5椰油酰胺、PEG-6椰油酰胺、PEG-7椰油酰胺、PEG-3月桂酰胺、PEG-5月桂酰胺、PEG-3油酰胺、PPG-2椰油酰胺、PPG-2羟乙基椰油酰胺、PPG-2羟乙基异硬脂酰胺以及它们的混合物。
代表性的聚氧乙烯化醇包括烷基链在C9-C16范围内,并且具有约1至约110个烷氧基基团的那些,包括但不限于月桂基聚氧乙烯醚-3、月桂基聚氧乙烯醚-23、鲸蜡基聚氧乙烯醚-10、硬脂基聚氧乙烯醚-10、硬脂基聚氧乙烯醚-100、山嵛基聚氧乙烯醚-10、和可以商品名91、23、25、45、135、l 67、PC 100、PC 200、PC 600从Shell Chemicals(Houston,Texas)商购获得的那些、以及它们的混合物。
还可商购获得的是可以商品名从Uniqema(Wilmington,Delaware)商购获得的聚氧乙烯脂肪酯,包括但不限于30、35、52、56、58、72、76、78、93、97、98、721、以及它们的混合物。
合适的烷基糖苷和烷基多葡糖苷可由式(S)n-O-R表示,其中S为糖部分诸如葡萄糖、果糖、甘露糖、半乳糖等;n为约1至约1000的整数,并且R为C8-C30烷基基团。烷基基团可衍生自其的长链醇的示例包括癸醇、月桂醇、十四烷醇、鲸蜡醇、硬脂醇、油醇等。这些表面活性剂的示例包括烷基多葡糖苷,其中S为葡萄糖部分,R为C8-20烷基基团,并且n为约1至约9的整数。这些表面活性剂的可商购获得的示例包括以商品名325CS、600CS和625CS)购自Cognis(Ambler,Pa)的癸基多葡糖苷和月桂基多葡糖苷。还可用于本文的是蔗糖酯表面活性剂诸如蔗糖椰油酸酯、和蔗糖月桂酸酯、以及以商品名TritonTMBG-10和TritonTMCG-110购自The Dow Chemical Company(Houston,Tx)的烷基多葡糖苷。
适用于本发明的其它非离子表面活性剂为甘油酯和聚甘油酯,其包括但不限于,甘油基单酯,C12-22饱和、不饱和和支链脂肪酸的甘油基单酯如油酸甘油酯、一硬脂酸甘油酯、一棕榈酸甘油酯、一山嵛酸甘油酯、以及它们的混合物,和C12-22饱和、不饱和和支链脂肪酸的聚甘油酯如聚甘油基-4异硬脂酸酯、聚甘油基-3油酸酯、聚甘油基-2-倍半油酸酯、二异硬脂酸三甘油酯、一油酸二甘油酯、一油酸四甘油酯、以及它们的混合物。
还可用作本文的非离子表面活性剂的是脱水山梨糖醇酯。C12-22饱和、不饱和和支链脂肪酸的脱水山梨糖醇酯可用于本文中。这些脱水山梨糖醇酯通常包括单酯、二酯、三酯等的混合物。合适的脱水山梨糖醇酯的代表性示例包括脱水山梨糖醇单月桂酸酯(20)、脱水山梨糖醇单棕榈酸酯(40)、脱水山梨糖醇单硬脂酸酯(60)、脱水山梨糖醇三硬脂酸酯(65)、脱水山梨糖醇单油酸酯(80)、脱水山梨糖醇三油酸酯(85)、和脱水山梨糖醇异硬脂酸酯。
还适用于本文的是脱水山梨糖醇酯的烷氧基化衍生物,包括但不限于均购自Uniqema的聚氧乙烯(20)脱水山梨糖醇单月桂酸酯(20)、聚氧乙烯(20)脱水山梨糖醇单棕榈酸酯40)、聚氧乙烯(20)脱水山梨糖醇单硬脂酸酯(60)、聚氧乙烯(20)脱水山梨糖醇单油酸酯(80)、聚氧乙烯(4)脱水山梨糖醇单月桂酸酯21)、聚氧乙烯(4)脱水山梨糖醇单硬脂酸酯(61)、聚氧乙烯(5)脱水山梨糖醇单油酸酯(81)、以及它们的混合物。
还适用于本文的是烷基酚乙氧基化物,包括但不限于壬基酚乙氧基化物(购自TheDow Chemical Company(Houston,Tx.)的TergitolTMNP-4、NP-6、NP-7、NP-8、NP-9、NP-10、NP-11、NP-12、NP-13、NP-15、NP-30、NP-40、NP-50、NP-55、NP-70)以及辛基酚乙氧基化物(购自The Dow Chemical Company(Houston,TX)的TritonTMX-15、X-35、X-45、X-114、X-100、X-102、X-165、X-305、X-405、X-705)。
还适用于本文的是叔烷基胺氧化物,包括月桂基氧化胺和椰油基氧化胺。
适用于个人护理组合物中的其它阴离子、两性离子、两性和非离子附加表面活性剂的非限制性示例描述于McCutcheon的Emulsifiers and Detergents(1989年鉴,由M.C.Publishing Co.)出版和美国专利3,929,678、2,658,072;2,438,091;2,528,378中,这些文献全文以引用方式并入本文。
适宜的表面活性剂组合包含约0.5%至约30%,或者约1%至约25%,或者约2%至约20%的烷基支链的平均重量%。
表面活性剂组合可具有约7.5%至约25%,或者约10%至约22.5%,或者约10%至约20%的C8至C12烷基链长度的累积平均重量%。
表面活性剂组合可具有约3至约200,或者约25至约175.5,或者约50至约150,或者约75至约125的平均C8-C12/C13-C18烷基链比率。
阳离子聚合物
个人护理组合物还包含阳离子聚合物。这些阳离子聚合物可包括以下中的至少一种:(a)阳离子瓜尔胶聚合物,(b)阳离子非瓜尔胶半乳甘露聚糖聚合物,(c)阳离子木薯聚合物,(d)丙烯酰胺单体和阳离子单体的阳离子共聚物,和/或(e)合成的非交联阳离子聚合物,其在与去污表面活性剂组合后可形成或可不形成溶致液晶,(f)阳离子纤维素聚合物。另外,阳离子聚合物可为阳离子聚合物的混合物。
个人护理组合物可包含阳离子瓜尔胶聚合物,其为阳离子取代的半乳甘露聚糖(瓜尔)树胶衍生物。用于制备这些瓜尔胶衍生物的瓜尔胶通常以天然存在的来自瓜尔胶植物种子的材料形式获得。瓜尔胶分子自身为按规则的间隔在交替的甘露糖单元上以单节半乳糖单元支化的直链甘露聚糖。甘露糖单元经由β(1-4)糖苷键连接基彼此连接。经由α(1-6)键,发生半乳糖支化。通过聚半乳甘露聚糖的羟基基团与反应性季铵化合物之间的反应,来获得瓜尔胶的阳离子衍生物。阳离子基团到瓜尔胶结构上的取代度应足以提供上文所述的所需阳离子电荷密度。
阳离子聚合物可包括但不限于阳离子瓜尔胶聚合物,其具有小于2,200,000g/mol、或约150,000至约2,200,000g/mol、或约200,000至约2,200,000g/mol、或约300,000至约1,200,000g/mol、或约750,000至约1,000,000g/mol的重均分子量。阳离子瓜尔胶聚合物可具有约0.2meq/g至约2.2meq/g、或约0.3meq/g至约2.0meq/g、或约0.4meq/g至约1.8meq/g;或约0.5meq/g至约1.8meq/g的电荷密度。
阳离子瓜尔胶聚合物可具有小于约1,500,000g/mol的重均分子量,并且具有约0.1meq/g至约2.5meq/g的电荷密度。阳离子瓜尔胶聚合物可具有小于900,000g/mol、或约150,000g/mol至约800,000g/mol、或约200,000g/mol至约700,000g/mol、或约300,000g/mol至约700,000g/mol、或约400,000g/mol至约600,000g/mol、或约150,000g/mol至约800,000g/mol、或约200,000g/mol至约700,000g/mol、或约300,000g/mol至约700,000g/mol、或约400,000g/mol至约600,000g/mol的重均分子量。阳离子瓜尔胶聚合物可具有约0.2meq/g至约2.2meq/g、或约0.3meq/g至约2.0meq/g、或约0.4meq/g至约1.8meq/g;或约0.5meq/g至约1.5meq/g的电荷密度。
阳离子瓜尔胶聚合物可由季铵化合物形成。用于形成阳离子瓜尔胶聚合物的季铵化合物可符合通式1:
其中R3、R4和R5为甲基或乙基基团;R6为具有通式2的环氧烷基基团:
或R6为具有通式3的卤代醇基团:
其中R7为C1至C3亚烷基;X为氯或溴,并且Z为阴离子,诸如Cl-、Br-、I-或HSO4-。
阳离子瓜尔胶聚合物可符合通式4:
其中R8为瓜尔胶;并且其中R4、R5、R6和R7如上所定义;并且其中Z为卤素。阳离子瓜尔胶聚合物可符合式5:
合适的阳离子瓜尔胶聚合物包括阳离子瓜尔胶衍生物,诸如瓜尔羟丙基三甲基氯化铵。阳离子瓜尔胶聚合物可为瓜尔羟丙基三甲基氯化铵。瓜尔羟丙基三甲基氯化铵的具体示例包括可从Solvay商购获得的系列,例如可从Solvay商购获得的C-500。C-500具有0.8meq/g的电荷密度和500,000g/mol的分子量。其它合适的瓜尔羟丙基三甲基氯化铵为:具有约1.3meq/g的电荷密度和约500,000g/mol的分子量,并且以商品名Optima购自Solvay的瓜尔羟丙基三甲基氯化铵。其它合适的瓜尔羟丙基三甲基氯化铵为:具有约0.7meq/g的电荷密度和约1,500,000g/mol的分子量,并且以商品名Excel购自Solvay的瓜尔羟丙基三甲基氯化铵。其它合适的瓜尔羟丙基三甲基氯化铵为:具有约1.1meq/g的电荷密度和约500,000g/mol的分子量并且购自ASI的瓜尔羟丙基三甲基氯化铵,具有约1.5meq/g的电荷密度和约500,000g/mol的分子量并且购自ASI的瓜尔羟丙基三甲基氯化铵。其它合适的瓜尔羟丙基三甲基氯化铵为:Hi-Care 1000,其具有约0.7meq/g的电荷密度和约600,000g/mol的分子量,并且购自Solvay;N-Hance 3269和N-Hance 3270,其具有约0.7meq/g的电荷密度和约425,000g/mol的分子量,并且购自ASI;N-Hance 3196,其具有约0.8meq/g的电荷密度和约1,100,000g/mol的分子量,并且购自ASI。AquaCat CG518具有约0.9meq/g的电荷密度,和约50,000g/mol的分子量,并且购自ASI。BF-13,其为具有约1meq/g的电荷密度和约800,000的分子量的无硼酸盐(硼)的瓜尔胶,以及BF-17,其为具有约1.5meq/g的电荷密度和约800,000的分子量的无硼酸盐(硼)的瓜尔胶,并且二者均购自ASI。
本发明的个人护理组合物可包含半乳甘露聚糖聚合物衍生物,以单体对单体计,半乳甘露聚糖聚合物衍生物具有的甘露糖与半乳糖的比率大于2:1,半乳甘露聚糖聚合物衍生物选自由以下组成的组:阳离子半乳甘露聚糖聚合物衍生物和具有净正电荷的两性半乳甘露聚糖聚合物衍生物。如本文所用,术语“阳离子半乳甘露聚糖”是指向其中加入阳离子基团的半乳甘露聚糖聚合物。术语“两性半乳甘露聚糖”是指向其中加入阳离子基团和阴离子基团以使得聚合物具有净正电荷的半乳甘露聚糖聚合物。
半乳甘露聚糖聚合物存在于豆科种子胚乳中。半乳甘露聚糖聚合物由甘露糖单体和半乳糖单体的组合构成。半乳甘露聚糖分子为按规则的间隔在特定甘露糖单元上以单节半乳糖单元支化的直链甘露聚糖。甘露糖单元经由β(1-4)糖苷键连接基彼此连接。经由α(1-6)键,发生半乳糖支化。甘露糖单体与半乳糖单体的比率根据植物的品种而改变,并且还受气候的影响。以单体对单体计,本发明非瓜尔胶半乳甘露聚糖聚合物衍生物具有大于2:1的甘露糖与半乳糖的比率。合适的甘露糖与半乳糖的比率可大于约3:1,并且甘露糖与半乳糖的比率可大于约4:1。甘露糖与半乳糖比率的分析是本领域熟知的,并且通常基于半乳糖含量的测量。
用于制备非瓜尔胶半乳甘露聚糖聚合物衍生物的树胶通常以天然存在的材料形式获得,诸如来自植物的种子或豆形果实。各种非瓜尔胶半乳甘露聚糖聚合物的示例包括但不限于塔拉胶(3份甘露糖/1份半乳糖)、刺槐豆胶或角豆胶(4份甘露糖/1份半乳糖)和肉桂胶(5份甘露糖/1份半乳糖)。
非瓜尔胶半乳甘露聚糖聚合物衍生物可具有约1,000至约10,000,000、和/或约5,000至约3,000,000的M.Wt.。
本发明的个人护理组合物还可包含半乳甘露聚糖聚合物衍生物,其具有约0.5meq/g至约7meq/g的阳离子电荷密度。该半乳甘露聚糖聚合物衍生物可具有约1meq/g至约5meq/g的阳离子电荷密度。半乳甘露聚糖结构上的阳离子基团的取代度应足以提供所需的阳离子电荷密度。
半乳甘露聚糖聚合物衍生物可为非瓜尔胶半乳甘露聚糖聚合物的阳离子衍生物,该衍生物由聚半乳甘露聚糖聚合物的羟基基团与反应性季铵化合物之间的反应获得。用于形成阳离子半乳甘露聚糖聚合物衍生物的合适的季铵化合物包括符合如上定义的通式1至5的那些。
由上述试剂形成的阳离子非瓜尔胶半乳甘露聚糖聚合物衍生物由通式6表示:
其中R为树胶。阳离子半乳甘露聚糖衍生物可为树胶羟丙基三甲基氯化铵,其可更具体地由通式7表示:
另选地,半乳甘露聚糖聚合物衍生物可为具有净正电荷的两性半乳甘露聚糖聚合物衍生物,当阳离子半乳甘露聚糖聚合物衍生物还包含阴离子基团时,获得两性半乳甘露聚糖聚合物衍生物。
阳离子非瓜尔胶半乳甘露聚糖可具有大于约4:1的甘露糖与半乳糖的比率,约1,000g/mol至约10,000,000g/mol、和/或约50,000g/mol至约1,000,000g/mol、和/或约100,000g/mol至约900,000g/mol、和/或约150,000g/mol至约400,000g/mol的分子量,以及约1meq/g至约5meq/g、和/或2meq/g至约4meq/g的阳离子电荷密度,并且可来源于肉桂植物。
个人护理组合物可包含水溶性阳离子改性淀粉聚合物。如本文所用,术语“阳离子改性淀粉”是指在使淀粉降解至具有较小分子量之前向其中加入阳离子基团的淀粉,或在使淀粉改性以获得期望的分子量之后向其中加入阳离子基团的淀粉。术语“阳离子改性淀粉”的定义还包括两性改性淀粉。术语“两性改性淀粉”是指向其中加入阳离子基团和阴离子基团的淀粉水解产物。
本文公开的阳离子改性淀粉聚合物具有约0.5%至约4%的结合氮百分比。
用于个人护理组合物中的阳离子改性淀粉聚合物可具有约850,000g/mol至约1,500,000g/mol和/或约900,000g/mol至约1,500,000g/mol的分子量。
个人护理组合物可包含阳离子改性淀粉聚合物,其具有约0.2meq/g至约5meq/g、和/或约0.2meq/g至约2meq/g的电荷密度。获得此类电荷密度的化学改性包括但不限于向淀粉分子中加入氨基和/或铵基团。这些铵基团的非限制性示例可包括取代基,诸如羟丙基三甲基氯化铵、三甲基羟丙基氯化铵、二甲基硬脂基羟丙基氯化铵和二甲基十二烷基羟丙基氯化铵。参见Solarek,D.B.,Cationic Starches in Modified Starches:Propertiesand Uses(Wurzburg,O.B.编辑,CRC Press,Inc.,Boca Raton,Fla.1986,第113-125页)。可将阳离子基团在淀粉降解至具有较小分子量之前加入到淀粉中,或可将阳离子基团在此类改性之后加入到其中。
阳离子改性淀粉聚合物通常具有约0.2至约2.5的阳离子基团取代度。如本文所用,阳离子改性淀粉聚合物的“取代度”是每个由取代基衍生的葡糖酐单元上羟基基团数的平均量度。由于每个葡糖酐单元具有三个可被取代的羟基基团,因此最大可能的取代度为3。以摩尔平均计,取代度表示为每摩尔葡糖酐单元具有的取代基摩尔数。取代度可使用本领域熟知的质子核磁共振光谱(“.sup.1H NMR”)方法来测定。合适的.sup.1H NMR技术包括描述于“Observation on NMR Spectra of Starches in Dimethyl Sulfoxide,Iodine-Complexing,and Solvating in Water-Dimethyl Sulfoxide”,Qin-Ji Peng and ArthurS.Perlin,Carbohydrate Research,160(1987),57-72;和“An Approach to theStructural Analysis of Oligosaccharides by NMR Spectroscopy”,J.HowardBradbury and J.Grant Collins,Carbohydrate Research,71,(1979),15-25中。
在化学改性之前的淀粉来源可选自多种来源,诸如块茎、豆类、谷类和粮食。这种来源的淀粉的非限制性示例可包括玉米淀粉、小麦淀粉、稻米淀粉、蜡质玉米淀粉、燕麦淀粉、木薯淀粉(cassava starch)、蜡质大麦淀粉、蜡质稻米淀粉、麸质稻米淀粉、糯米淀粉、支链淀粉、马铃薯淀粉、木薯淀粉(tapioca starch)、燕麦淀粉、西米淀粉、糯米、或它们的混合物。
阳离子改性淀粉聚合物可选自降解的阳离子玉米淀粉、阳离子木薯、阳离子马铃薯淀粉、以及它们的混合物。另选地,阳离子改性淀粉聚合物为阳离子玉米淀粉和阳离子木薯。
在降解至具有较小分子量之前或在改性至具有较小分子量之后,淀粉可包括一种或多种附加的改性。例如,这些改性可包括交联、稳定化反应、磷酸化和水解。稳定性反应可包括烷基化和酯化。
阳离子改性淀粉聚合物可以水解淀粉(例如酸、酶或碱降解)、氧化淀粉(例如过氧化物、过酸、次氯酸盐、碱或任何其它氧化剂)、物理/机械降解淀粉(例如经由处理设备的热机械能输入)、或它们组合的形式掺入组合物中。
淀粉的最佳形式是一种易于溶解于水中并在水中形成基本上澄清(600nm下约80的透射百分比)溶液的形式。组合物的透明度通过紫外/可见(UV/VIS)分光光度测定法来测定,其使用Gretag Macbeth Colorimeter Color i 5根据相关指导说明,测定样品对UV/VIS光的吸收或透过。已示出,600nm的光波长足以表征化妆品组合物的透明度。
用于个人护理组合物中的合适的阳离子改性淀粉购自已知的淀粉供应商。还适用于个人护理组合物中的是非离子改性淀粉,如本领域所已知的,该非离子改性淀粉可被进一步衍生为阳离子改性淀粉。如本领域已知的是,其他合适的改性淀粉原料可被季铵化以产生适用于个人护理组合物中的阳离子改性淀粉聚合物。
淀粉降解过程:通过在水中混合颗粒状淀粉,可制得淀粉浆液。将温度升至约35℃。然后加入基于淀粉计约50ppm浓度的高锰酸钾水溶液。用氢氧化钠将pH升至约11.5,并且将浆液充分搅拌,以防止淀粉沉降。然后加入在水中稀释的约30%的过氧化氢溶液,使过氧化物的水平基于淀粉计为约1%。然后通过加入附加的氢氧化钠,将pH恢复至约11.5。将反应在约1至约20小时的时段内完成。然后将该混合物用稀盐酸中和。降解淀粉通过过滤接着洗涤并干燥来重新获得。
个人护理组合物可包含丙烯酰胺单体和阳离子单体的阳离子共聚物,其中共聚物具有约1.0meq/g至约3.0meq/g的电荷密度。阳离子共聚物可为丙烯酰胺单体和阳离子单体的合成阳离子共聚物。
阳离子共聚物可包含:
(i)具有下式AM的丙烯酰胺单体:
其中R9为H或C1-4烷基;并且R10和R11独立地选自H、C1-4烷基、CH2OCH3、CH2OCH2CH(CH3)2和苯基,或合在一起为C3-6环烷基;和
(ii)符合式CM的阳离子单体:
其中k=1,v、v'和v”中的每一者独立地为1至6的整数,w为零或1至10的整数,并且X-为阴离子。
阳离子单体可符合式CM,并且其中k=1,v=3,并且w=0,z=1,并且X-为Cl-,以形成以下结构:
上述结构可被称为二季铵盐。另选地,阳离子单体可符合式CM,并且其中v和v”各自为3,v'=1,w=1,y=1,并且X-为Cl-,诸如:
上述结构可被称为三季铵盐。
合适的丙烯酰胺单体包括但不限于丙烯酰胺或甲基丙烯酰胺。
阳离子共聚物(b)可为AM:TRIQUAT,其为丙烯酰胺和N-[2-[[[二甲基[3-[(2-甲基-1-氧代-2-丙烯基)氨基]丙基]铵基]乙酰基]氨基]乙基]2-羟基-N,N,N',N',N'-五甲基-1,3-丙二铵三氯化物的共聚物。AM:TRIQUAT还被称为聚季铵盐-76(PQ76)。AM:TRIQUAT可具有1.6meq/g的电荷密度和1,100,000g/mol的分子量。
阳离子共聚物可具有丙烯酰胺单体和阳离子单体,其中阳离子单体选自:(甲基)丙烯酸二甲基氨基乙酯、(甲基)丙烯酸二甲基氨基丙酯、(甲基)丙烯酸二叔丁基氨基乙酯、二甲基氨甲基(甲基)丙烯酰胺、二甲基氨丙基(甲基)丙烯酰胺;乙烯亚胺、乙烯胺、2-乙烯基吡啶、4-乙烯基吡啶;(甲基)丙烯酸三甲基氯化铵乙酯、(甲基)丙烯酸三甲基甲基硫酸铵乙酯、(甲基)丙烯酸二甲基苄基氯化铵乙酯、丙烯酸4-苯甲酰基苄基二甲基氯化铵乙酯、三甲基氯化铵乙基(甲基)丙烯酰胺、三甲基氯化铵丙基(甲基)丙烯酰胺、乙烯基苄基三甲基氯化铵、二烯丙基二甲基氯化铵、以及它们的混合物。
阳离子共聚物可包含阳离子单体,该阳离子单体选自:阳离子单体包括(甲基)丙烯酸三甲基氯化铵乙酯、(甲基)丙烯酸三甲基甲基硫酸铵乙酯、(甲基)丙烯酸二甲基苄基氯化铵乙酯、丙烯酸4-苯甲酰基苄基二甲基氯化铵乙酯、三甲基氯化铵乙基(甲基)丙烯酰胺、三甲基氯化铵丙基(甲基)丙烯酰胺、乙烯基苄基三甲基氯化铵、以及它们的混合物。
阳离子共聚物可为水溶性的。阳离子共聚物由以下形成:(1)(甲基)丙烯酰胺和基于(甲基)丙烯酰胺的阳离子单体和/或水解稳定的阳离子单体的共聚物,(2)(甲基)丙烯酰胺、基于阳离子(甲基)丙烯酸酯的单体、和基于(甲基)丙烯酰胺的单体、和/或水解稳定的阳离子单体的三聚物。基于阳离子(甲基)丙烯酸酯的单体可为含有季铵化N原子的(甲基)丙烯酸的阳离子化酯。含有季铵化N原子的(甲基)丙烯酸的阳离子化酯可为在烷基和亚烷基基团中具有C1至C3的季铵化(甲基)丙烯酸二烷基氨基烷基酯。合适的含有季铵化N原子的(甲基)丙烯酸的阳离子化酯可选自:用氯甲烷季铵化的(甲基)丙烯酸二甲基氨基甲酯的铵盐、(甲基)丙烯酸二甲基氨基乙酯的铵盐、(甲基)丙烯酸二甲基氨基丙酯的铵盐、(甲基)丙烯酸二乙基氨基甲酯的铵盐、(甲基)丙烯酸二乙基氨基乙酯的铵盐;以及(甲基)丙烯酸二乙基氨基丙酯的铵盐。包含季铵化的N原子的(甲基)丙烯酸的阳离子化酯可为用卤代烷、或用氯甲烷、或苄基氯、或硫酸二甲酯季铵化的丙烯酸二甲基氨基乙酯(ADAME-Quat)。当基于(甲基)丙烯酰胺时,阳离子单体可为在烷基和亚烷基基团中具有C1至C3的季铵化二烷基氨基烷基(甲基)丙烯酰胺,或者用卤代烷、或氯甲烷、或苄基氯、或硫酸二甲酯季铵化的二甲基氨基丙基丙烯酰胺。
合适的基于(甲基)丙烯酰胺的阳离子单体包括在烷基和亚烷基基团中具有C1至C3的季铵化二烷基氨基烷基(甲基)丙烯酰胺。基于(甲基)丙烯酰胺的阳离子单体可为二甲基氨基丙基丙烯酰胺,其用卤代烷(尤其是氯甲烷)或苄基氯或硫酸二甲酯季铵化。
阳离子单体可为水解稳定的阳离子单体。除了二烷基氨基烷基(甲基)丙烯酰胺以外,水解稳定的阳离子单体还可为OECD水解测试可以认为稳定的所有单体。阳离子单体可为水解稳定的,并且水解稳定的阳离子单体可选自:二烯丙基二甲基氯化铵和水溶性阳离子苯乙烯衍生物。
阳离子共聚物可为丙烯酰胺、用氯甲烷季铵化的(甲基)丙烯酸2-二甲基铵乙酯(ADAME-Q)、和用氯甲烷季铵化的3-二甲基铵丙基(甲基)丙烯酰胺(DIMAPA-Q)的三元共聚物。阳离子共聚物可由丙烯酰胺和丙烯酰胺基丙基三甲基氯化铵形成,其中丙烯酰胺基丙基三甲基氯化铵具有约1.0meq/g至约3.0meq/g的电荷密度。
阳离子共聚物可具有约1.1meq/g至约2.5meq/g、或约1.1meq/g至约2.3meq/g、或约1.2meq/g至约2.2meq/g、或约1.2meq/g至约2.1meq/g、或约1.3meq/g至约2.0meq/g、或约1.3meq/g至约1.9meq/g的电荷密度。
阳离子共聚物可具有约100,000g/mol至约1,500,000g/mol、或约300,000g/mol至约1,500,000g/mol、或约500,000g/mol至约1,500,000g/mol、或约700,000g/mol至约1,000,000g/mol、或约900,000g/mol至约1,200,000g/mol的分子量。
阳离子共聚物可以为三甲基铵丙基甲基丙烯酰胺氯化物-N-丙烯酰胺共聚物,其还被称为AM:MAPTAC。AM:MAPTAC可具有约1.3meq/g的电荷密度和约1,100,000g/mol的分子量。阳离子共聚物可以为AM:ATPAC。AM:ATPAC可具有约1.8meq/g的电荷密度和约1,100,000g/mol的分子量。
(a)阳离子合成聚合物
个人护理组合物可包含可由以下形成的阳离子合成聚合物
i)一种或多种阳离子单体单元,和任选地
ii)一种或多种带有负电荷的单体单元,和/或
iii)非离子单体,
其中共聚物的随后电荷是正的。三种类型的单体的比率以“m”、“p”和“q”给出,其中“m”为阳离子单体的数目,“p”为带有负电荷的单体的数目,并且“q”为非离子单体的数目
阳离子聚合物可为具有以下结构的水溶性或水可分散的非交联并且合成的阳离子聚合物:
其中A可为以下阳离子部分中的一种或多种:
其中@=酰胺基、烷基酰胺基、酯、醚、烷基、或烷基芳基;
其中Y=C1-C22烷基、烷氧基、烷叉基、烷基、或芳氧基;
其中ψ=C1-C22烷基、烷氧基、烷基芳基、或烷基芳氧基;。
其中Z=C1-C22烷基、烷氧基、芳基、或芳氧基;
其中R1=H、C1-C4直链或支链烷基;
其中s=0或1,n=0或≥1;
其中T和R7=C1-C22烷基;和
其中X-=卤素、氢氧根、链烷醇根、硫酸根或烷基硫酸根。
其中带有负电荷的单体由以下定义:R2'=H、C1-C4直链或支链烷基,并且R3为:
其中D=O、N、或S;
其中Q=NH2或O;
其中u=1至6;
其中t=0至1;和
其中J=含有以下元素P、S、C的氧化官能团。
其中非离子单体由以下定义:R2”=H、C1-C4直链或支链烷基,R6=直链或支链烷基、烷基芳基、芳氧基、烷氧基、烷基芳氧基,并且β定义为
其中G‘和G”彼此独立地为O、S或N-H,并且L=0或1。
阳离子单体的示例包括(甲基)丙烯酸氨基烷基酯、(甲基)氨基烷基(甲基)丙烯酰胺;包含至少一个仲、叔或季铵官能团,或含有氮原子的杂环基团、乙烯胺或乙烯亚胺的单体;二烯丙基二烷基铵盐;它们的混合物、它们的盐以及从它们衍生出的大分子单体。
阳离子单体的另外示例包括(甲基)丙烯酸二甲基氨基乙酯、(甲基)丙烯酸二甲基氨基丙酯、(甲基)丙烯酸二叔丁基氨基乙酯、二甲基氨基甲基(甲基)丙烯酰胺、二甲基氨基丙基(甲基)丙烯酰胺、乙烯亚胺、乙烯胺、2-乙烯基吡啶、4-乙烯基吡啶、(甲基)丙烯酸三甲基氯化铵乙酯、(甲基)丙烯酸三甲基甲基硫酸铵乙酯、(甲基)丙烯酸二甲基苄基氯化铵乙酯、丙烯酸4-苯甲酰基苄基二甲基氯化铵乙酯、三甲基氯化铵乙基(甲基)丙烯酰胺、三甲基氯化铵丙基(甲基)丙烯酰胺、乙烯基苄基三甲基氯化铵、二烯丙基二甲基氯化铵。
合适的阳离子单体包括包含式-NR3 +的季铵基团的那些,其中R相同或不同,代表氢原子、包含1至10个碳原子的烷基基团,或苄基基团,任选地带有羟基基团,并且包括阴离子(抗衡离子)。阴离子的示例为卤离子(诸如氯离子、溴离子)、硫酸根、硫酸氢根、烷基硫酸根(例如,包含1至6个碳原子)、磷酸根、柠檬酸根、甲酸根和乙酸根。
合适的阳离子单体包括(甲基)丙烯酸三甲基氯化铵乙酯、(甲基)丙烯酸三甲基甲基硫酸铵乙酯、(甲基)丙烯酸二甲基苄基氯化铵乙酯、丙烯酸4-苯甲酰基苄基二甲基氯化铵乙酯、三甲基氯化铵乙基(甲基)丙烯酰胺、三甲基氯化铵丙基(甲基)丙烯酰胺、乙烯基苄基三甲基氯化铵。
附加合适的阳离子单体包括三甲基氯化铵丙基(甲基)丙烯酰胺。
带有负电荷的单体的示例包括包含磷酸根或膦酸根基团的α-烯键式不饱和单体、α-烯键式不饱和一元羧酸、α-烯键式不饱和二元羧酸的单烷基酯、α-烯键式不饱和二元羧酸的单烷基酰胺、包含磺酸基团的α-烯键式不饱和化合物、以及包含磺酸基团的α-烯键式不饱和化合物的盐。
具有负电荷的合适单体包括丙烯酸、甲基丙烯酸、乙烯基磺酸、乙烯基磺酸的盐、乙烯基苯磺酸、乙烯基苯磺酸的盐、α-丙烯酰胺基甲基丙磺酸、α-丙烯酰胺基甲基丙磺酸的盐、甲基丙烯酸2-磺基乙酯、甲基丙烯酸2-磺基乙酯的盐、丙烯酰胺基-2-甲基丙磺酸(AMPS)、丙烯酰胺基-2-甲基丙磺酸的盐、以及苯乙烯磺酸盐(SS)。
非离子单体的示例包括乙酸乙烯酯、α-烯键式不饱和羧酸的酰胺、具有氢化或氟化醇的α-烯键式不饱和一元羧酸的酯、聚环氧乙烷(甲基)丙烯酸酯(即,聚乙氧基化的(甲基)丙烯酸)、α-烯键式不饱和二元羧酸的单烷基酯、α-烯键式不饱和二元羧酸的单烷基酰胺、乙烯基腈、乙烯胺酰胺、乙烯醇、乙烯基吡咯烷酮和乙烯基芳族化合物。
合适的非离子单体包括苯乙烯、丙烯酰胺、甲基丙烯酰胺、丙烯腈、丙烯酸甲酯、丙烯酸乙酯、丙烯酸正丙酯、丙烯酸正丁酯、甲基丙烯酸甲酯、甲基丙烯酸乙酯、甲基丙烯酸正丙酯、甲基丙烯酸正丁酯、丙烯酸2-乙基-己酯、甲基丙烯酸2-乙基-己酯、丙烯酸2-羟乙酯和甲基丙烯酸2-羟乙酯。
与合成阳离子聚合物缔合的阴离子抗衡离子(X-)可为任何已知的抗衡离子,只要聚合物在水中、在个人护理组合物中、或在个人护理组合物中的凝聚层相中保持可溶解或可分散,并且只要抗衡离子在物理和化学上与个人护理组合物的基本组分相容,或不以其它方式不当地破坏产品的性能、稳定性或美观性。此类抗衡离子的非限制性示例包括卤离子(例如,氯、氟、溴、碘)、硫酸根和甲硫酸根。
本文所述的阳离子聚合物可有助于向受损毛发,尤其是经化学处理的毛发提供替代疏水性F层。极薄的F-层在提供天然耐候性的同时有助于密封水分并防止进一步损伤。化学处理会损伤毛发表皮并且使其保护性F-层剥离。当F-层被剥离时,毛发变得日益亲水。已发现,当溶致液晶被施用到化学处理过的毛发上时,毛发在外观和感觉两者上变得更加疏水且更像天然的。不受任何理论所束缚,据信该溶致液晶复合物形成疏水层或膜,其覆盖毛发纤维并且保护毛发,如同天然的F-层保护毛发那样。疏水层恢复毛发成通常像未处理的、更健康的状态。溶致液晶通过将本文所述的合成阳离子聚合物与前述个人护理组合物的阴离子去污表面活性剂组分混合来形成。合成阳离子聚合物具有相对高的电荷密度。应当指出,一些具有相对高阳离子电荷密度的合成聚合物不形成溶致液晶,这主要是由于它们不正常的直链电荷密度。此类合成阳离子聚合物描述于授予Reich等人的WO 94/06403中。本文所述的合成聚合物可配制于稳定的个人护理组合物中,该个人护理组合物针对受损毛发提供改善的调理性能。
可形成溶致液晶的阳离子合成聚合物具有约2meq/gm至约7meq/gm,和/或约3meq/gm至约7meq/gm,和/或约4meq/gm至约7meq/gm的阳离子电荷密度。阳离子电荷密度可以为约6.2meq/gm。聚合物还具有约1,000至约5,000,000、和/或约10,000至约1,500,000、和/或约100,000至约1,500,000的M.Wt.。
在本发明中,提供增强的调理性和有益剂沉积但无需形成溶致液晶的阳离子合成聚合物可具有约0.7meq/gm至约7meq/gm,和/或约0.8meq/gm至约5meq/gm,和/或约1.0meq/gm至约3meq/gm的阳离子电荷密度。聚合物还可具有约1,000至约1,500,000、约10,000至约1,500,000和约100,000至约1,500,000的M.Wt.。
合适的阳离子纤维素聚合物为羟乙基纤维素与三甲基铵取代的环氧化物反应所得的盐,其在工业(CTFA)上被称为聚季铵盐-10,并且以它们的Polymer LR、JR和KG聚合物系列购自Dow/Amerchol Corp.(Edison,N.J.,USA)。非限制性示例包括:JR-30M、KG-30M、JP,LR-400以及它们的混合物。阳离子纤维素的其它合适类型包括羟乙基纤维素与月桂基二甲基铵取代的环氧化物反应所得的聚合季铵盐,其在工业(CTFA)上被称为聚季铵盐-24。这些材料以商品名Polymer LM-200购自Dow/Amerchol Corp.。其它合适类型的阳离子纤维素包括羟乙基纤维素与月桂基二甲基铵取代的环氧化物以及三甲基铵取代的环氧化物反应所得的聚合季铵盐,其在工业(CTFA)上被称为聚季铵盐-67。这些材料以商品名SoftCATPolymer SL-5、SoftCAT Polymer SL-30、Polymer SL-60、Polymer SL-100、Polymer SK-L、Polymer SK-M、Polymer SK-MH、和Polymer SK-H购自Dow/Amerchol Corp.。
阳离子聚合物的浓度按个人护理组合物的重量计在约0.025%至约5%、约0.1%至约3%、和/或约0.2%至约1%的范围内。
稳定聚合物
个人护理组合物可包含稳定聚合物以增加组合物的粘度。可使用合适的稳定聚合物。个人护理组合物可包含约0.05%至10%和0.1%至约9%的稳定、约0.4%至约8%的稳定聚合物、约0.7%至约5%的稳定改性聚合物、以及约1%至约2.5%的稳定聚合物。稳定聚合物改性剂可为聚丙烯酸酯、聚丙烯酰胺增稠剂。稳定聚合物可为阴离子稳定聚合物。
毛发个人护理组合物可包含稳定聚合物,该稳定聚合物是基于丙烯酸、甲基丙烯酸或其它相关衍生物的均聚物,非限制性示例包括聚丙烯酸酯、聚甲基丙烯酸酯、聚丙烯酸乙酯和聚丙烯酰胺。
稳定聚合物可为碱溶胀性和疏水改性的碱溶胀性丙烯酸类共聚物或甲基丙烯酸酯共聚物,非限制性示例包括丙烯酸/丙烯腈共聚物、丙烯酸酯/硬脂基聚氧乙烯醚-20衣康酸酯共聚物、丙烯酸酯/鲸蜡基聚氧乙烯醚-20衣康酸酯共聚物、丙烯酸酯/氨基丙烯酸酯/C10-30烷基PEG-20衣康酸酯共聚物、丙烯酸酯/氨基丙烯酸酯共聚物、丙烯酸酯/硬脂基聚氧乙烯醚-20甲基丙烯酸酯共聚物、丙烯酸酯/山嵛基聚氧乙烯醚-25甲基丙烯酸酯共聚物、丙烯酸酯/硬脂基聚氧乙烯醚-20甲基丙烯酸酯交联聚合物、丙烯酸酯/山嵛基聚氧乙烯醚-25甲基丙烯酸酯/HEMA交联聚合物、丙烯酸酯/新癸酸乙烯酯交联聚合物、丙烯酸酯/异癸酸乙烯酯交联聚合物、丙烯酸酯/棕榈油醇聚醚-25丙烯酸酯共聚物、丙烯酸/丙烯酰胺基甲基丙烷磺酸共聚物、以及丙烯酸酯/丙烯酸C10-C30烷基酯交联聚合物。
稳定聚合物可为可溶性交联丙烯酸类聚合物,非限制性示例包括卡波姆。
稳定聚合物可为缔合聚合物增稠剂,非限制性示例包括:疏水改性的碱溶胀性乳液,非限制性示例包括疏水改性的聚丙烯酸酯;疏水改性的聚丙烯酸和疏水改性的聚丙烯酰胺;疏水改性的聚醚,其中这些材料可具有选自鲸蜡基、硬脂基、油酰基、以及它们的组合的疏水物。
稳定聚合物可与聚乙烯吡咯烷酮、交联的聚乙烯吡咯烷酮和衍生物组合使用。稳定聚合物可与聚乙烯醇和衍生物组合。稳定聚合物可与聚乙烯亚胺和衍生物组合。
稳定聚合物可与基于藻酸的材料组合,非限制性示例包括藻酸钠和藻酸丙二醇酯。
稳定聚合物可与聚氨基甲酸酯聚合物组合使用,非限制性示例包括:疏水改性的烷氧基化氨基甲酸酯聚合物,非限制性示例包括PEG-150/癸醇/SMDI共聚物、PEG-150/硬脂醇/SMDI共聚物、聚氨基甲酸酯-39。
稳定聚合物可与缔合聚合物增稠剂组合,非限制性示例包括:疏水改性的纤维素衍生物;以及具有10-300、30-200和40-150个重复单元的环氧乙烷重复基团的亲水部分。该类型的非限制性示例包括PEG-120-甲基葡萄糖二油酸酯、PEG–(40或60)脱水山梨糖醇四油酸酯、PEG-150季戊四醇四硬脂酸酯、PEG-55丙二醇油酸酯、PEG-150二硬脂酸酯。
稳定聚合物可与纤维素和衍生物组合,非限制性示例包括微晶纤维素、羧甲基纤维素、羟乙基纤维素、羟丙基纤维素、羟丙基甲基纤维素、甲基纤维素、乙基纤维素;硝基纤维素;纤维素硫酸盐;纤维素粉末;疏水改性的纤维素。
稳定聚合物可与瓜尔胶和瓜尔胶衍生物组合,非限制性示例包括羟丙基瓜尔胶和羟丙基瓜尔胶羟丙基三甲基氯化铵。
稳定聚合物可与以下组合:聚环氧乙烷;聚环氧丙烷;以及POE-PPO共聚物。
稳定聚合物可与由以下通式表征的聚亚烷基二醇组合:
其中R为氢、甲基、或它们的混合物;其中R为氢,并且n为具有2,000-180,000、或7,000-90,000、或7,000-45,000的平均数的整数。这种类型的非限制性示例包括PEG-7M、PEG-14M、PEG-23M、PEG-25M、PEG-45M、PEG-90M、或PEG-100M。
稳定聚合物可与二氧化硅组合,非限制性示例包括热解法二氧化硅、沉淀二氧化硅、和经有机硅表面处理的二氧化硅。
稳定聚合物可与水溶胀性粘土组合,非限制性示例包括合成锂皂石、膨润土、蒙脱石、绿土和锂蒙脱石。
稳定聚合物可与树胶组合,非限制性示例包括黄原胶、瓜尔胶、羟丙基瓜尔胶、阿拉伯胶、黄蓍胶、半乳聚糖、长豆角胶、刺梧桐树胶和刺槐豆胶。
稳定聚合物可与以下物质组合:二亚苄基山梨醇、卡拉根(karaggenan)、果胶、琼脂、温柏树籽(榅桲子)、淀粉(来自稻米、玉米、马铃薯、小麦等)、淀粉衍生物(例如羧甲基淀粉、甲基羟丙基淀粉)、藻类提取物、右旋糖酐、琥珀酰葡聚糖和普鲁兰(pulleran)。
稳定聚合物的非限制性示例包括丙烯酰胺/丙烯酸铵共聚物(和)聚异丁烯(和)聚山梨酸酯20;丙烯酰胺/丙烯酰二甲基牛磺酸钠共聚物/异十六烷/聚山梨酸酯80、丙烯酰二甲基牛磺酸铵/VP共聚物、丙烯酸钠/丙烯酰二甲基牛磺酸钠共聚物、丙烯酸酯共聚物、丙烯酸酯交联聚合物-4、丙烯酸酯交联聚合物-3、丙烯酸酯/山嵛基聚氧乙烯醚-25甲基丙烯酸酯共聚物、丙烯酸酯/丙烯酸C10-C30烷基酯交联聚合物、丙烯酸酯/硬脂基聚氧乙烯醚-20衣康酸酯共聚物、聚丙烯酸铵/异十六烷/PEG-40蓖麻油;卡波姆、卡波姆钠、交联的聚乙烯吡咯烷酮(PVP)、聚丙烯酰胺/C13-14异链烷烃/月桂基聚氧乙烯醚-7、聚丙烯酸酯13/聚异丁烯/聚山梨酸酯20、聚丙烯酸酯交联聚合物-6、聚酰胺-3、聚季铵盐-37(和)氢化聚癸烯(和)十三烷基聚氧乙烯醚-6、丙烯酰胺/丙烯酰二甲基牛磺酸钠/丙烯酸共聚物、丙烯酸钠/丙烯酰二甲基牛磺酸盐/二甲基丙烯酰胺、交联聚合物(和)异十六烷(和)聚山梨酸酯60、聚丙烯酸钠。示例性可商购获得的稳定聚合物包括:ACULYNTM28、ACULYNTM88、ACULYNTM33、ACULYNTM22、ACULYNTMExcel、Aqua SF-1、ETD 2020、Ultrez 20、Ultrez 21、Ultrez 10、Ultrez 30、1342、Aqua SF-2聚合物、SepigelTM305、SimulgelTM600、SepimaxZen、SMART 1000、TTA、SC-Plus、PLUS、AVC、Stabylen 30、以及它们的组合。
悬浮蜡
合适的稳定剂包括具有下式的亚烷基二醇的单酯和/或二酯:
其中R1为直链或支链C12-C22烷基基团;
R为直链或支链C2-C4亚烷基基团;
P选自H、C1-C4烷基或–COR2,R2为C4-C22烷基,在另一个实施方案中C12-C22烷基;和
n=1-3。
在一个实施方案中,长链脂肪酯具有上述通式结构,其中R1为直链或支链C16-C22烷基基团,R为-CH2-CH2-,并且P选自H或–COR2,其中R2为C4-C22烷基,在另一个实施方案中C12-C22烷基。
典型的示例是乙二醇、丙二醇、二乙二醇、二丙二醇、三乙二醇或四乙二醇与含有约6至约22个、约12至约18个碳原子的脂肪酸诸如己酸、辛酸、2-乙基己酸、癸酸、月桂酸、异十三烷酸、肉豆蔻酸、棕榈酸、棕榈油酸、硬脂酸、异硬脂酸、油酸、反油酸、岩芹酸、亚油酸、亚麻酸、花生酸、鳕油酸、山嵛酸、芥酸的单酯和/或二酯、以及它们的混合物。
在一个实施方案中,乙二醇单硬脂酸酯(EGMS)和/或乙二醇二硬脂酸酯(EGDS)和/或聚乙二醇单硬脂酸酯(PGMS)和/或聚乙二醇二硬脂酸酯(PGDS)为组合物中所用的悬浮蜡。存在这些材料的若干商业来源。例如,可从Stepan获得,Empilan可从Albright&Wilson获得。
传统上,甘油酯化合物可以用作个人护理组合物的结构剂。例如,R为三羟基硬脂精,由Elementis Specialties of New Jersey生产的商业氢化蓖麻油,并且作为用于个人护理组合物的稳定剂和结构剂销售。适用于本文所述的个人护理组合物的甘油酯可选自任何可结晶甘油酯,其可以允许在包含合适的表面活性剂和阳离子聚合物的个人护理组合物中形成凝聚层。例如,合适的甘油酯是氢化蓖麻油,诸如三羟基硬脂精或二羟基硬脂精。
附加的可结晶甘油酯的示例可包括基本上纯的12-羟基硬脂酸的甘油三酯。12-羟基硬脂酸是纯形式的完全氢化的12-羟基-9-顺式十八碳烯酸的甘油三酯。可理解,许多另外的甘油酯是可能的。例如,氢化过程的变化和蓖麻油的天然变化可使得能够由蓖麻油生产另外合适的甘油酯。
合适的甘油酯也可以由一种或多种甘油酯的混合物形成。例如,包含按混合物的重量计约80%或更多的蓖麻油的甘油酯混合物可为合适的。其它合适的混合物可包含仅甘油三酯的混合物、甘油二酯和甘油三酯的混合物、甘油三酯与甘油二酯和有限量(例如,按混合物的重量计小于约20%)的甘油单酯的混合物;或它们的任何混合物,其包含按混合物的重量计约20%或更少的任何甘油酯的对应酸水解产物。按重量计约80%或更多的混合物可以与完全氢化蓖麻油酸的甘油酯(即12-羟基硬脂酸的甘油酯)化学相同。可以改性氢化蓖麻油,使得在给定甘油三酯中,将存在两个12-羟基硬脂酸部分和一个硬脂酸部分。另选地,可以使用部分氢化。然而,聚(烷氧基化)蓖麻油不是合适的,因为其具有不合适的熔点。
蓖麻油包括包含掺有羟基基团的C10至C22烷基或烯基部分的甘油酯,尤其是甘油三酯。蓖麻油的氢化通过转化双键来产生氢化蓖麻油,所述双键作为蓖蓖麻油基部分存在于起始油中。这些部分被转化为蓖麻油基部分,其是饱和羟烷基部分,例如羟基硬脂基。在一些实施方案中,本文的氢化蓖麻油(HCO)可选自:三羟基硬脂精;二羟基硬脂精;以及它们的混合物。HCO可以任何合适的起始形式处理,包括但不限于选自固体、熔融物以及它们的混合物的那些。可用的HCO可具有以下特征:约40℃至约100℃、另选地约65℃至约95℃的熔点;和/或约0至约5、另选地约0至约4、以及另选地约0至约2.6的碘值范围。HCO的熔点可以使用DSC:差示扫描量热法来测量。
本发明不旨在仅涉及使用氢化蓖麻油。可以使用任何其它合适的可结晶甘油酯。在一个示例中,结构剂是基本上纯的12-羟基硬脂酸的甘油三酯。该分子表示纯形式的完全氢化的12-羟基-9-顺式十八碳烯酸的甘油三酯。在本质上,蓖麻油的组成可以稍微变化。同样,氢化程序可以变化。可以使用任何其它合适的等效材料,诸如甘油三酯的混合物,其中至少约80重量%来自蓖麻油。示例性等效材料主要包括或由甘油三酯组成;或者主要包括或由甘油二酯和甘油三酯的混合物组成;或者主要包括或由甘油三酯与甘油二酯和有限量(例如,按甘油酯混合物的重量计小于约20重量%)的甘油单酯的混合物组成;或者主要包括或由任何前述甘油酯组成:其具有有限量(例如,小于约20重量%)的任何所述甘油酯的对应酸水解产物。
稳定预混物包含按个人护理组合物的重量计约4%至约30%的100%活性物质稳定剂。在另一个实施方案中,稳定预混物包含约15%至约25%的稳定剂。
悬浮蜡可以约0.01%至约4%而处于本发明中;悬浮蜡可以约0.1%至约3%而处于本发明中;悬浮蜡可以约0.5%至约2%而处于本发明中;悬浮蜡可以约0.3%至约1.5%而处于本发明中。
水混溶性溶剂
个人护理组合物的载体可包括水和以下的水溶液:低级烷基醇、多元醇、具有3至4个碳原子的酮、C1-C6醇的C1-C6酯、亚砜、酰胺、碳酸酯、乙氧基化和丙氧基化C1-C10醇、内酯、吡咯烷酮、以及它们的混合物。非限制性低级烷基醇为具有1个至6个碳的一元醇,诸如乙醇和异丙醇。可用于本文的多元醇的非限制性示例包括丙二醇、二丙二醇、丁二醇、己二醇、甘油、丙二醇、以及它们的混合物。
在本发明中,个人护理组合物可包含水溶助长剂/粘度调节剂,其为低级烷基苯磺酸盐的碱金属盐或铵盐,诸如二甲苯磺酸钠、异丙基苯磺酸钠或甲苯磺酸钠。本发明可包含约0.1%至约6%的二甲苯磺酸钠(SXS)。
在本发明中,个人护理组合物可包含有机硅/PEG-8有机硅/PEG-9有机硅/PEG-n有机硅/有机硅醚(n可为另一个整数),非限制性示例包括PEG8-聚二甲基硅氧烷A208)MW855、PEG 8聚二甲基硅氧烷D208 MW 2706。
头皮健康剂
在本发明中,可添加一种或多种头皮健康剂以提供头皮有益效果,以提供抗真菌/去头皮屑功效或者附加头皮有益效果。该组材料是变化的并且提供广泛范围的有益效果,包括保湿、阻隔改善、抗真菌、抗微生物和抗氧化剂、抗痒剂和感觉剂、以及附加的去头皮屑剂诸如吡啶硫酮的多价金属盐,非限制性示例包括吡啶硫酮锌(ZPT)和吡啶硫酮铜、硫或硫化硒。此类头皮健康剂包括但不限于:维生素E和F、水杨酸、烟酰胺、咖啡因、泛醇、氧化锌、碳酸锌、碱式碳酸锌、二醇、乙醇酸、PCA、PEG、赤藓醇、甘油、三氯生、乳酸酯、透明质酸酯、尿囊素和其它脲、甜菜碱、山梨醇、谷氨酸酯、木糖醇、薄荷醇、乳酸薄荷酯、异环酮、苄醇、包含以下结构的化合物:
R1选自H、烷基、氨基烷基、烷氧基;
Q=H2、O、-OR1、-N(R1)2、-OPO(OR1)x、-PO(OR1)x、-P(OR1)x,其中x=1-2;
V=NR1、O、-OPO(OR1)x、-PO(OR1)x、-P(OR1)x,其中x=1-2;
W=H2、O;
对于n=0,X、Y=独立地选自H、芳基、萘基;
对于n≥1,X、Y=脂族CH2或芳族CH,并且Z选自脂族CH2、芳族CH或杂原子;
A=低级烷氧基、低级烷硫基、芳基、取代的芳基或稠合芳基;和
立体化学能够在标记*的位置处变化。
以及天然提取物/油,包括薄荷油、留兰香、摩洛哥坚果油、霍霍巴油和芦荟。
所述组合物还可包含以下头皮健康剂中的一种或多种,所述头皮健康剂包括:煤焦油、木炭、复方苯甲酸软膏、卡斯太拉尼氏涂剂、氯化铝、龙胆紫、羟甲辛吡酮(吡罗克酮乙醇胺)、环吡酮胺、十一碳烯酸及其金属盐、嘧菌酯和其它strobulins、高锰酸钾、硫代硫酸钠、丙二醇、苦橙油、尿素制剂、灰黄霉素、8-羟基喹啉氯碘羟喹、硫代地巴唑、硫代氨基甲酸酯、卤普罗近、聚烯、羟基吡啶酮、吗啉、苄胺、烯丙胺(诸如特比萘芬)、茶树油、丁香叶油、芫荽、玫瑰草、小檗碱、百里香红、桂皮油、肉桂醛、香茅酸、扁柏酚、页岩油、Sensiva SC-50、Elestab HP-100、壬二酸、溶细胞酶、碘代丙炔基丁基氨基甲酸酯(IPBC)、异噻唑啉酮诸如辛基异噻唑啉酮、和唑类、伊曲康唑、酮康唑、苯并咪唑、苯并噻唑、联苯苄唑、硝酸布他康唑、氯咪巴唑、克霉唑、氯康唑、依柏康唑、益康唑、新康唑、芬替康唑、氟康唑、氟曲吗唑、异康唑、酮康唑、兰诺康唑、甲硝唑、咪康唑、奈替康唑、奥莫康唑、硝酸奥昔康唑、舍他康唑、硝酸硫康唑、噻康唑、噻唑、特康唑、以及它们的混合物。
任选成分
在本发明中,个人护理组合物还可包含一种或多种任选成分,包括有益剂。合适的有益剂包括但不限于调理剂、阳离子聚合物有机硅乳液、去头皮屑剂、凝胶网络、螯合剂、以及天然油脂诸如葵花油或蓖麻油。另外合适的任选成分包括但不限于香料、香料微胶囊、着色剂、颗粒、抗微生物剂、泡沫抑制剂、抗静电剂、流变改性剂和增稠剂、悬浮材料和结构剂、pH调节剂和缓冲剂、防腐剂、珠光剂、溶剂、稀释剂、抗氧化剂、维生素、以及它们的组合。在本发明中,香料可以约0.5%至约7%存在。
可包含一种或多种稳定剂。例如,可包含乙二醇二硬脂酸酯、柠檬酸、柠檬酸盐、防腐剂诸如kathon、氯化钠、苯甲酸钠和乙二胺四乙酸(“EDTA”)中的一种或多种,以改善个人护理组合物的寿命。
此类任选成分应在物理和化学上与组合物的组分相容,并且不应以其它方式不当地破坏产品的稳定性、美观性或性能。《CTFA Cosmetic Ingredient Handbook》第十版(由Cosmetic、Toiletry和Fragrance Association公司公布,华盛顿)(2004)(下文称为“CTFA”)描述了各种各样可加入到本文组合物中的非限制性材料。
调理剂
个人护理组合物的调理剂可为有机硅调理剂。有机硅调理剂可包含挥发性有机硅、非挥发性有机硅、或它们的组合。有机硅调理剂的浓度通常在按组合物的重量计约0.01%至约10%、约0.1%至约8%、约0.1%至约5%、和/或约0.2%至约3%的范围内。合适的有机硅调理剂和用于有机硅的任选悬浮剂的非限制性示例描述于美国再公告专利34,584、美国专利5,104,646和美国专利5,106,609中,这些专利以引用方式并入本文。
用于本发明组合物中的有机硅调理剂可具有如在25C下测量的约20至约2,000,000厘沲("csk")、约1,000至约1,800,000csk、约10,000至约1,500,000csk、和/或约20,000至约1,500,000csk的粘度。
分散的有机硅调理剂颗粒通常具有在约0.01微米至约60微米范围内的体积平均粒径。对于施用于毛发的小颗粒,体积平均粒径通常在约0.01微米至约4微米、约0.01微米至约2微米、约0.01微米至约0.5微米的范围内。
包括论述有机硅流体、硅橡胶纯胶料和有机硅树脂以及有机硅制造的各章节在内的有关有机硅的附加资料可参见Encyclopedia of Polymer Science and Engineering,第15卷,第2版,第204-308页,John Wiley&Sons,Inc.(1989),该文献以引用方式并入本文。
适用于本发明的有机硅乳液可包括但不限于根据美国专利6,316,541或美国专利4,476,282或美国专利申请公布2007/0276087中提供的描述制得的不溶性聚硅氧烷乳液。因此,合适的不溶性聚硅氧烷包括聚硅氧烷,诸如α,ω-羟基封端的聚硅氧烷或α,ω-烷氧基封端的聚硅氧烷,其具有约5csk至约500,000csk的内相粘度。例如,不溶性聚硅氧烷可具有如下内相粘度:小于400,000csk;小于200,000csk;约10,000csk至约180,000csk。不溶性聚硅氧烷可具有在约10nm至约10微米范围内的平均粒度。平均粒度可在约15nm至约5微米,约20nm至约1微米,或约25nm至约500nm的范围内。
不溶性聚硅氧烷的平均分子量、不溶性聚硅氧烷的内相粘度、有机硅乳液的粘度、和包含不溶性聚硅氧烷的颗粒的尺寸由本领域技术人员常用的方法测定,诸如公开于Smith,A.L.的The Analytical Chemistry of Silicones,John Wiley&Sons,Inc.:NewYork,1991中的方法。例如,有机硅乳液的粘度可在30℃下用Brookfield粘度计和锭子6以2.5rpm来测量。有机硅乳液还可包括附加乳化剂以及阴离子表面活性剂。
适用于本发明组合物中的其他类型的有机硅包括但不限于:i)有机硅流体,包括但不限于有机硅油,其为具有如在25℃下测量的小于约1,000,000csk的粘度的可流动材料;ii)氨基硅氧烷,该氨基硅氧烷包含至少一个伯胺、仲胺或叔胺;iii)阳离子有机硅,该阳离子有机硅包含至少一个季铵官能团;iv)硅橡胶纯胶料;其包括具有如在25℃下测量的大于或等于1,000,000csk的粘度的材料;v)有机硅树脂,该有机硅树脂包括高度交联的聚合硅氧烷体系;vi)高折射率有机硅,该高折射率有机硅具有至少1.46的折射率,以及vii)它们的混合物。
本发明的个人护理组合物的调理剂还可包含单独或与其他调理剂诸如上述有机硅组合的至少一种有机调理材料诸如油或蜡。有机材料可以是非聚合的、低聚的或聚合的。它可为油或蜡的形式,并且可以纯制剂或以预乳化形式添加。有机调理材料的一些非限制性示例包括但不限于:i)烃油;ii)聚烯烃;iii)脂肪酯;iv)氟化调理化合物;v)脂肪醇;vi)烷基葡糖苷和烷基葡糖苷衍生物;vii)季铵化合物;viii)具有至多约2,000,000的分子量的聚乙二醇和聚丙二醇,包括具有CTFA名称PEG-200、PEG-400、PEG-600、PEG-1000、PEG-2M、PEG-7M、PEG-14M、PEG-45M的那些、以及它们的混合物。
凝胶网络
在本发明中,可存在凝胶网络。本发明的凝胶网络组分包含至少一种脂族两亲物。如本文所用,“脂族两亲物”是指具有疏水性尾部基团和亲水性头部基团的化合物,该疏水性尾部基团被定义为C12-C70长度的烷基、烯基(包含至多3个双键)、烷基芳族或支链烷基基团,该亲水性头部基团使化合物不溶于水,其中该化合物在洗发剂组合物的pH下还具有净电中性。
本发明的洗发剂组合物可包含以按洗发剂组合物的重量计约0.05%至约14%、约0.5%至约10%、约1%至约8%的量作为预形成的分散凝胶网络相的一部分的脂族两亲物。
根据本发明,适宜的脂族两亲物或两种或更多种脂族两亲物的适宜混合物具有至少约27℃的熔点。如本文所用,熔点可通过如U.S.Pharmacopeia,USP-NF General Chapter<741>“Melting range or temperature”中所述的标准熔点方法进行测量。通过将两种或更多种材料在高于各自熔点的温度下混合,然后使该混合物冷却,来确定两种或更多种材料的混合物的熔点。如果所得复合材料在低于约27℃下为均匀的固体,则混合物具有适用于本发明的熔点。两种或更多种脂族两亲物的混合物也适用于本发明,前提条件是混合物的复合熔点为至少约27℃,其中混合物包含至少一种独立熔点小于约27℃的脂族两亲物。
本发明的适宜脂族两亲物包括脂肪醇、烷氧基化脂肪醇、脂肪酚、烷氧基化脂肪酚、脂肪酰胺、烷氧基化脂肪酰胺、脂肪胺、脂肪烷基酰胺基烷基胺、脂肪烷氧基化胺、脂肪氨基甲酸酯、脂肪胺氧化物、脂肪酸、烷氧基化脂肪酸、脂肪二酯、脂肪脱水山梨糖醇酯、脂肪糖酯、甲基葡糖苷酯、脂肪乙二醇酯、甘油一酯、甘油二酯和甘油三酯、聚甘油脂肪酯、烷基甘油基醚、丙二醇脂肪酸酯、胆固醇、神经酰胺、脂肪有机硅蜡、脂肪葡萄糖酰胺和磷脂以及它们的混合物。
在本发明中,洗发剂组合物可包含脂肪醇凝胶网络。这些凝胶网络通过将脂肪醇与表面活性剂以约1:1至约40:1、约2:1至约20:1、和/或约3:1至约10:1的比率混合来形成。凝胶网络的形成涉及将脂肪醇在水中的分散体与表面活性剂加热至高于脂肪醇的熔点的温度。在混合过程期间,脂肪醇熔融,从而允许表面活性剂能够分隔成脂肪醇液滴。表面活性剂将水与其一起携带到脂肪醇中。这使各向同性的脂肪醇滴剂变成液晶相滴剂。当将混合物冷却至低于链熔融温度时,液晶相转变成固体结晶凝胶网络。凝胶网络向美容霜膏和毛发调理剂提供稳定有益效果。此外,它们还递送毛发调理剂的调理感觉有益效果。
脂肪醇可以按重量计约0.05重量%至约14重量%的含量包含于脂肪醇凝胶网络中。例如,脂肪醇的含量可在约1重量%至约10重量%,和/或约6重量%至约8重量%范围内。
可用于本文的脂肪醇包括具有约10至约40个碳原子,约12至约22个碳原子,约16至约22个碳原子,或约16至约18个碳原子的那些。这些脂肪醇可为直链醇或支链醇,并且可为饱和或不饱和的。脂肪醇的非限制性示例包括鲸蜡醇、硬脂醇、山嵛醇、以及它们的混合物。比率为约20:80至约80:20的鲸蜡醇和硬脂醇的混合物是合适的。
凝胶网络制备:向容器中装入水并且将水加热至约74℃。将鲸蜡醇、硬脂醇和月桂基聚氧乙烯醚硫酸钠表面活性剂添加到加热的水中。掺入之后,使所得混合物穿过换热器,其中将混合物冷却至约35℃。冷却后,脂肪醇和表面活性剂结晶以形成结晶的凝胶网络。表1提供了示例凝胶网络组合物的组分和它们相应的量。
表1
凝胶网络组分
乳化剂
在本发明的个人护理组合物中可使用多种阴离子和非离子乳化剂。阴离子和非离子乳化剂在性质上可为单体或聚合物。例如,单体示例包括但不限于烷基乙氧基化物、烷基硫酸盐、皂和脂肪酸酯、以及它们的衍生物。经由说明并不受限制,聚合物的示例包括聚丙烯酸酯、聚乙二醇和嵌段共聚物、以及它们的衍生物。天然存在的乳化剂如羊毛脂、卵磷脂和木质素以及它们的衍生物也是可用乳化剂的非限制性示例。
螯合剂
个人护理组合物还可包含螯合剂。合适的螯合剂包括A E Martell&R M Smith的Critical Stability Constants第1卷(Plenum Press,New York&London(1974))和A EMartell&R D Hancock的Metal Complexes in Aqueous Solution(Plenum Press,NewYork&London(1996))中所列的那些,将两篇文献以引用方式并入本文。当涉及螯合剂时,术语“它们的盐及衍生物”是指具有与它们所涉及的螯合剂相同官能结构(例如相同化学主链)以及具有相似或更好螯合特性的盐和衍生物。该术语包括具有酸性部分的螯合剂的碱金属盐、碱土金属盐、铵盐、取代的铵(即单乙醇胺、二乙醇胺、三乙醇铵)盐、酯、以及它们的混合物,尤其是所有的钠盐、钾盐或铵盐。术语“衍生物”还包括“螯合表面活性剂”化合物,诸如美国专利5,284,972中例示的那些,以及包含一个或多个具有与母体螯合剂相同官能结构的螯合基团的大分子诸如美国专利5,747,440中公开的聚合物EDDS(乙二胺二琥珀酸)。
螯合剂可以按总组合物的重量计0.001%至10.0%范围内、按总组合物的重量计0.01%至2.0%范围内的量掺入本文的组合物中。
非限制性螯合剂类别包括羧酸、氨基羧酸,其包括氨基酸、磷酸、膦酸、多膦酸、聚乙烯亚胺、多官能取代的芳族化合物、它们的衍生物和盐。
非限制性螯合剂包括下列物质和它们的盐。乙二胺四乙酸(EDTA)、乙二胺三乙酸、乙二胺-N,N'-二琥珀酸(EDDS)、乙二胺-N,N'-二戊二酸(EDDG)、水杨酸、天冬氨酸、谷氨酸、甘氨酸、丙二酸、组氨酸、二亚乙基三胺五乙酸盐(DTPA)、N-羟乙基乙二胺三乙酸盐、次氮基三乙酸盐、乙二胺四丙酸盐、三亚乙基四胺六乙酸盐、乙醇基二甘氨酸、丙二胺四乙酸盐(PDTA)、甲基甘氨酸二乙酸(MODAA)、二亚乙基三胺五乙酸、甲基甘氨酸二乙酸(MGDA)、N-酰基-N,N',N'-乙二胺三乙酸、次氮基三乙酸、乙二胺二戊二酸(EDGA)、2-羟基丙二胺二琥珀酸(HPDS)、甘氨酰胺-N,N'-二琥珀酸(GADS)、2-羟基丙二胺-N-N'-二琥珀酸(HPDDS)、N-2-羟乙基-N,N-二乙酸、甘油亚氨基二乙酸、亚氨基二乙酸-N-2-羟丙基磺酸、天冬氨酸N-羧甲基-N-2-羟丙基-3-磺酸、丙氨酸-N,N'-二乙酸、天冬氨酸-N,N'-二乙酸、天冬氨酸N-一乙酸、亚氨基二琥珀酸、二胺-N,N'-二多元酸、单酰胺-N,N'-二多元酸、二氨基烷基二(磺基琥珀酸)(DDS)、乙二胺-N-N'-双(邻羟基苯基乙酸)、N,N'-双(2-羟基苄基)乙二胺-N,N'-二乙酸、乙二胺四丙酸盐、三亚乙基四胺六乙酸盐、二亚乙基三胺五乙酸盐、吡啶二羧酸、亚乙基二半胱氨酸(EDC)、乙二胺-N,N'-双(2-羟基苯乙酸)(EDDHA)、谷氨酸二乙酸(GLDA)、六腺苷酸氨基羧酸盐(HBED)、聚乙烯亚胺、1-羟基二膦酸盐、氨基三(亚甲基膦酸)(ATMP)、次氮基三亚甲基膦酸盐(NTP)、乙二胺四亚甲基膦酸盐、二亚乙基三胺五亚甲基膦酸盐(DTPMP)、乙烷-1-羟基二膦酸盐(HEDP)、2-膦酰基丁烷-1,2,4-三羧酸、多磷酸、三聚磷酸钠、二磷酸四钠、六偏磷酸、偏磷酸钠、膦酸及其衍生物、氨基亚烷基-聚(亚烷基膦酸)、氨基三(1-乙基膦酸)、乙二胺四(1-乙基膦酸)、氨基三(1-丙基膦酸)、
氨基三(异丙基膦酸)、乙二胺四(亚甲基膦酸)(EDTMP)、1,2-二羟基-3,5-二磺基苯。
含水载体
个人护理组合物可为可倾倒液体的形式(环境条件下)。因此,此类组合物将通常包含载体,该载体以按个人护理组合物的重量计约40%至约85%、或者约45%至约80%、或者约50%至约75%的含量存在。载体可包含水,或水和有机溶剂的可混溶混合物,并且在一个方面,可包含水与最小或不显著浓度的有机溶剂,除了另外作为其它必要或任选组分的微量成分附带地掺入组合物中的那些。
可用于本发明的个人护理组合物中的载体可包括水以及低级烷基醇和多元醇的水溶液。可用于本文的低级烷基醇是具有1至6个碳的一元醇,在一个方面,为乙醇和异丙醇。可用于本文的示例性多元醇包括丙二醇、己二醇、甘油和丙烷二醇。
产品形式
本发明的个人护理组合物可呈现为典型的毛发护理制剂形式。它们可为溶液、分散体、乳液、粉剂、滑石、封装体、球体、海绵、固体剂型、泡沫、以及其它递送机制的形式。本发明的组合物可为生发油、免洗型毛发产品诸如处理物、以及定型产品、洗去型毛发产品诸如洗发剂和个人清洁产品、以及处理产品;以及可施用到毛发的任何其它形式。
施用装置
在本发明中,个人护理组合物可从施用装置分配以直接分配到头皮区域。经由定向递送施用装置直接分配到头皮上能够在清洁需求最高的地方直接沉积未稀释的清洁剂。这也使眼睛与清洁溶液接触的风险最小化。
施用装置附接或可附接到包含清洁个人护理组合物的瓶子上。施用装置可由容纳或延伸到单个或多个尖齿的基部组成。尖齿具有开口,所述开口可位于顶端、基部或顶端和基部之间的任何点处。这些开口允许产品从瓶中直接分配到毛发和/或头皮上。
另选地,施用装置也可由附接到基部或从基部延伸的刷状刷毛组成。在这种情况下,产品将从基部分配,并且刷毛将允许经由梳理或刷洗运动进行产品分配。
施用装置和尖齿设计和材料也可被优化以实现头皮按摩。在这种情况下,有利地是在顶端处的尖齿或刷毛几何形状更圆,类似于用于眼霜的滚珠施用装置。材料更光滑和更软也可能是有益的;例如,金属或金属样涂饰剂,“橡胶状材料”。
方法
粘度测量
可使用具有锥C75-1的锥板式Brookfield RS流变仪在2s-1的恒定剪切速率下在27℃下在3分钟时对于2.5mL样品测量洗发剂粘度。
本发明的个人护理组合物可具有约3000cps至约20,000cps的粘度;可具有约5000cps至约15,000cps的粘度;可具有约8000cps至约12,000cps的粘度。
吡啶硫酮锌(ZPT)沉积的测量
吡啶硫酮锌(ZPT)在头皮上的体内沉积可通过在利用含有ZPT的清洁组合物处理头皮并且冲洗掉之后,对试剂进行乙醇提取来测定。通过HPLC测量乙醇提取溶剂中的试剂浓度。通过参照标准曲线进行定量。通过使用浓度乘以体积,将通过HPLC检测到的浓度转化为以克为单位收集的量。
然后通过将测得的HPLC浓度乘以提取溶剂的体积除以提取的头皮面积,将质量每试剂体积浓度转换为质量每沉积面积量。
结果和非限制性实施例
表1
低于10%的总表面活性剂含量通常不具有高于3000cps的期望粘度。这可以在具有和不具有辅助表面活性剂的情况下看到。
表2
处于或高于10%的总表面活性剂含量通常能够获得在期望范围内的粘度。这在广泛范围的总表面活性剂含量和阴离子/辅助表面活性剂比率内观察到。
表3
阴离子表面活性剂/辅助表面活性剂的比率可以在约0.63至约14之间产生期望的粘度。具有高于约15的表面活性剂/辅助表面活性剂比率的配方,包括不具有辅助表面活性剂的那些,通常未成功获得期望的粘度特征。
洗发剂组合物的制备
通过在充分搅拌下添加表面活性剂、去头皮屑剂、香料、粘度调节剂、阳离子聚合物和水的其余部分来制备个人护理组合物,以确保均匀的混合物。可将混合物加热至50-75℃以加速可溶性试剂的溶解,然后冷却。可根据需要调节产品pH以提供适于施用到人的毛发和头皮上的本发明洗发剂组合物,并且基于特定去污表面活性剂和/或其它组分的选择,所述产品pH可从约pH 4变化至9,或从约pH 6.5变化至8,或从约pH 5.5变化至6.5。
沉积
在阴离子表面活性剂/辅助表面活性剂配方空间中,当阴离子表面活性剂与辅助表面活性剂的比率高(月桂基硫酸钠:椰油酰胺基丙基甜菜碱=13:1)时,如实施例19中所述,低分子量聚合物提供相当于对照配方的沉积。实施例18作为基准实施例提供,其高于可覆盖的乙氧基化表面活性剂%并且是本发明可获得的基准或标准。
在阴离子表面活性剂/辅助表面活性剂配方空间中,当阴离子表面活性剂与辅助表面活性剂的比率低(月桂基硫酸钠:CAPB+CMEA=10:4、9:4、8:5等)时,如实施例26至36中所述,高分子量或高电荷密度聚合物提供大于或相当于对照配方的沉积。实施例18作为基准实施例提供,其高于可覆盖的乙氧基化表面活性剂%并且是本发明可获得的基准或标准。
通过常规的配制方法和混合方法可制备以下实施例中举例说明的个人护理组合物。除非另外指明,否则所有例示量以基于活性物质的重量百分比列出,并且除了微量材料以外,诸如稀释剂、防腐剂、有色溶液、假想成分、植物药物等。除非另外指明,否则所有百分比均基于重量。
本文所公开的量纲和值不应理解为严格限于所引用的精确数值。相反,除非另外指明,否则每个此类量纲旨在表示所述值以及围绕该值功能上等同的范围。例如,公开为“40mm”的量纲旨在表示“约40mm”。
除非明确排除或以其他方式限制,否则本文中引用的每一篇文献,包括任何交叉引用或相关专利或专利申请以及本申请对其要求优先权或其有益效果的任何专利申请或专利,均据此全文以引用方式并入本文。对任何文献的引用不是对其作为与本发明的任何所公开或本文受权利要求书保护的现有技术的认可,或不是对其自身或与任何一个或多个参考文献的组合提出、建议或公开任何此类发明的认可。此外,当本发明中术语的任何含义或定义与以引用方式并入的文献中相同术语的任何含义或定义矛盾时,应当服从在本发明中赋予该术语的含义或定义。
虽然已举例说明和描述了本发明的具体实施方案,但是对于本领域技术人员来说显而易见的是,在不脱离本发明的实质和范围的情况下可作出各种其他变化和修改。因此,本文旨在于所附权利要求书中涵盖属于本发明范围内的所有此类变化和修改。
Claims (15)
1.一种个人护理组合物,包含:
a)6%至15%的月桂基硫酸钠;
b)0.63:1至15:1的月桂基硫酸钠与辅助表面活性剂的比率;
c)10%至20%的总表面活性剂;并且
具有3000cps至20,000cps的粘度,并且其中所述个人护理组合物包含小于2%的月桂基聚氧乙烯醚硫酸钠。
2.根据前述权利要求中任一项所述的个人护理组合物,其中所述月桂基硫酸钠为12%至15%。
3.根据前述权利要求中任一项所述的个人护理组合物,其中所述总表面活性剂为12%至15%。
4.根据前述权利要求中任一项所述的个人护理组合物,还包含0.25%至15%的一种或多种两性辅助表面活性剂、非离子辅助表面活性剂或两性离子辅助表面活性剂。
5.根据前述权利要求中任一项所述的个人护理组合物,其中所述辅助表面活性剂选自:椰油酰胺基乙基甜菜碱、椰油酰胺基丙基氧化胺、椰油酰胺基丙基甜菜碱、椰油酰胺基丙基二甲基氨基羟丙基水解胶原、椰油酰胺基丙基二甲基铵羟丙基水解胶原、椰油酰胺基丙基羟基磺基甜菜碱、椰油甜菜碱酰胺基两性基丙酸盐、椰油基甜菜碱、椰油基羟基磺基甜菜碱、椰油基/油基酰胺基丙基甜菜碱、椰油基磺基甜菜碱、月桂酰胺基丙基甜菜碱、月桂基甜菜碱、月桂基羟基磺基甜菜碱、月桂基磺基甜菜碱、椰油酰胺、椰油酰胺甲基MEA、椰油酰胺DEA、椰油酰胺MEA、椰油酰胺MIPA、月桂酰胺DEA、月桂酰胺MEA、月桂酰胺MIPA、十四酰胺DEA、十四酰胺MEA、PEG-20椰油酰胺MEA、PEG-2椰油酰胺、PEG-3椰油酰胺、PEG-4椰油酰胺、PEG-5椰油酰胺、PEG-6椰油酰胺、PEG-7椰油酰胺、PEG-3月桂酰胺、PEG-5月桂酰胺、PEG-3油酰胺、PPG-2椰油酰胺、PPG-2羟乙基椰油酰胺、PPG-2羟乙基异硬脂酰胺、以及它们的混合物。
6.根据前述权利要求中任一项所述的个人护理组合物,其中所述粘度为5000cps至15,000cps,优选地8000cps至12,000cps。
7.根据前述权利要求中任一项所述的个人护理组合物,其中所述月桂基硫酸钠:辅助表面活性剂的比率为3:1至13:1,优选地10:1至13:1。
8.根据前述权利要求中任一项所述的个人护理组合物,还包含0.1%至6%的二甲苯磺酸钠(SXS)。
9.根据前述权利要求中任一项所述的个人护理组合物,其中所述个人护理组合物包含小于1%的月桂基聚氧乙烯醚硫酸钠,优选地小于0.5%的月桂基聚氧乙烯醚硫酸钠,优选地包含0%的月桂基聚氧乙烯醚硫酸钠。
10.根据前述权利要求中任一项所述的个人护理组合物,其中所述组合物的pH为4至9,优选地6.5至8,优选地5.5至6.5。
11.根据前述权利要求中任一项所述的个人护理组合物,其中所述组合物还包含阳离子聚合物。
12.根据前述权利要求中任一项所述的个人护理组合物,其中所述组合物还包含凝胶网络。
13.根据前述权利要求中任一项所述的个人护理组合物,其中所述组合物还包含调理剂,优选地其中所述调理剂为有机硅。
14.根据前述权利要求中任一项所述的个人护理组合物,还包含一种或多种头皮健康剂,优选地其中所述头皮健康剂选自吡啶硫酮锌、水杨酸、吡罗克酮乙醇胺、嘧菌酯、氯咪巴唑、烟酰胺、薄荷醇和/乳酸甲酯、以及它们的混合物,优选地其中所述头皮健康剂为吡啶硫酮锌,优选地其中所述头皮健康剂为水杨酸,优选地其中所述头皮健康剂为薄荷醇和/或乳酸薄荷酯。
15.根据前述权利要求中任一项所述的个人护理组合物,还包含0.5%至7%的香料。
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