CN114845694A - 具有可溶性头皮健康活性物质的透明组合物 - Google Patents
具有可溶性头皮健康活性物质的透明组合物 Download PDFInfo
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- CN114845694A CN114845694A CN202080084929.0A CN202080084929A CN114845694A CN 114845694 A CN114845694 A CN 114845694A CN 202080084929 A CN202080084929 A CN 202080084929A CN 114845694 A CN114845694 A CN 114845694A
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- Prior art keywords
- sodium
- acrylate
- sulfate
- personal care
- ammonium
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 189
- 210000004761 scalp Anatomy 0.000 title claims abstract description 29
- 230000036541 health Effects 0.000 title claims abstract description 25
- 229920000642 polymer Polymers 0.000 claims abstract description 117
- 239000004094 surface-active agent Substances 0.000 claims abstract description 101
- 230000008719 thickening Effects 0.000 claims abstract description 42
- 229920001577 copolymer Polymers 0.000 claims abstract description 41
- 229920006317 cationic polymer Polymers 0.000 claims abstract description 37
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 18
- 229920000058 polyacrylate Polymers 0.000 claims abstract description 16
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims abstract description 10
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000002562 thickening agent Substances 0.000 claims abstract description 7
- 229920001519 homopolymer Polymers 0.000 claims abstract description 4
- 239000011734 sodium Substances 0.000 claims description 134
- 229910052708 sodium Inorganic materials 0.000 claims description 134
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 107
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 90
- -1 polyoxyethylene Polymers 0.000 claims description 78
- 229940048053 acrylate Drugs 0.000 claims description 64
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims description 62
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 56
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 40
- 229920001296 polysiloxane Polymers 0.000 claims description 38
- 125000000217 alkyl group Chemical group 0.000 claims description 36
- 239000003795 chemical substances by application Substances 0.000 claims description 24
- 159000000001 potassium salts Chemical class 0.000 claims description 19
- 230000003750 conditioning effect Effects 0.000 claims description 18
- 239000000463 material Substances 0.000 claims description 17
- 229920002125 Sokalan® Polymers 0.000 claims description 15
- 239000003945 anionic surfactant Substances 0.000 claims description 14
- 229920006037 cross link polymer Polymers 0.000 claims description 14
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 13
- BANXPJUEBPWEOT-UHFFFAOYSA-N 2-methyl-Pentadecane Chemical compound CCCCCCCCCCCCCC(C)C BANXPJUEBPWEOT-UHFFFAOYSA-N 0.000 claims description 12
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims description 10
- 125000004432 carbon atom Chemical group C* 0.000 claims description 10
- 150000008051 alkyl sulfates Chemical class 0.000 claims description 9
- 239000002245 particle Substances 0.000 claims description 9
- 239000002304 perfume Substances 0.000 claims description 9
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims description 8
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 8
- 229920002401 polyacrylamide Polymers 0.000 claims description 7
- 229940043268 2,2,4,4,6,8,8-heptamethylnonane Drugs 0.000 claims description 6
- KUVMKLCGXIYSNH-UHFFFAOYSA-N isopentadecane Natural products CCCCCCCCCCCCC(C)C KUVMKLCGXIYSNH-UHFFFAOYSA-N 0.000 claims description 6
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 6
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 6
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 6
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical class OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 5
- 125000002811 oleoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 5
- PQUXFUBNSYCQAL-UHFFFAOYSA-N 1-(2,3-difluorophenyl)ethanone Chemical compound CC(=O)C1=CC=CC(F)=C1F PQUXFUBNSYCQAL-UHFFFAOYSA-N 0.000 claims description 4
- OWEGWHBOCFMBLP-UHFFFAOYSA-N 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one Chemical group C1=CN=CN1C(C(=O)C(C)(C)C)OC1=CC=C(Cl)C=C1 OWEGWHBOCFMBLP-UHFFFAOYSA-N 0.000 claims description 4
- 229920002367 Polyisobutene Polymers 0.000 claims description 4
- 229920001213 Polysorbate 20 Polymers 0.000 claims description 4
- 239000003513 alkali Substances 0.000 claims description 4
- 229960001631 carbomer Drugs 0.000 claims description 4
- 229960003344 climbazole Drugs 0.000 claims description 4
- 150000002430 hydrocarbons Chemical group 0.000 claims description 4
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 4
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims description 4
- 229960004889 salicylic acid Drugs 0.000 claims description 4
- 229940047670 sodium acrylate Drugs 0.000 claims description 4
- FWFUWXVFYKCSQA-UHFFFAOYSA-M sodium;2-methyl-2-(prop-2-enoylamino)propane-1-sulfonate Chemical compound [Na+].[O-]S(=O)(=O)CC(C)(C)NC(=O)C=C FWFUWXVFYKCSQA-UHFFFAOYSA-M 0.000 claims description 4
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 4
- 239000005730 Azoxystrobin Substances 0.000 claims description 3
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims description 3
- 229920001214 Polysorbate 60 Polymers 0.000 claims description 3
- 229930182692 Strobilurin Natural products 0.000 claims description 3
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical class OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 claims description 3
- WFDXOXNFNRHQEC-GHRIWEEISA-N azoxystrobin Chemical compound CO\C=C(\C(=O)OC)C1=CC=CC=C1OC1=CC(OC=2C(=CC=CC=2)C#N)=NC=N1 WFDXOXNFNRHQEC-GHRIWEEISA-N 0.000 claims description 3
- 150000001768 cations Chemical class 0.000 claims description 3
- 229930195712 glutamate Natural products 0.000 claims description 3
- BTSZTGGZJQFALU-UHFFFAOYSA-N piroctone olamine Chemical group NCCO.CC(C)(C)CC(C)CC1=CC(C)=CC(=O)N1O BTSZTGGZJQFALU-UHFFFAOYSA-N 0.000 claims description 3
- 229940081510 piroctone olamine Drugs 0.000 claims description 3
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims description 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 3
- 229940068977 polysorbate 20 Drugs 0.000 claims description 3
- 229920000053 polysorbate 80 Polymers 0.000 claims description 3
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 2
- YTLYLLTVENPWFT-UPHRSURJSA-N (Z)-3-aminoacrylic acid Chemical compound N\C=C/C(O)=O YTLYLLTVENPWFT-UPHRSURJSA-N 0.000 claims description 2
- DWHIUNMOTRUVPG-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCO DWHIUNMOTRUVPG-UHFFFAOYSA-N 0.000 claims description 2
- ICIDSZQHPUZUHC-UHFFFAOYSA-N 2-octadecoxyethanol Chemical compound CCCCCCCCCCCCCCCCCCOCCO ICIDSZQHPUZUHC-UHFFFAOYSA-N 0.000 claims description 2
- WHNPOQXWAMXPTA-UHFFFAOYSA-N 3-methylbut-2-enamide Chemical compound CC(C)=CC(N)=O WHNPOQXWAMXPTA-UHFFFAOYSA-N 0.000 claims description 2
- 229920002126 Acrylic acid copolymer Polymers 0.000 claims description 2
- 102100026735 Coagulation factor VIII Human genes 0.000 claims description 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 2
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 claims description 2
- 229920003188 Nylon 3 Polymers 0.000 claims description 2
- 229920002690 Polyoxyl 40 HydrogenatedCastorOil Polymers 0.000 claims description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 2
- UJNOLBSYLSYIBM-WISYIIOYSA-N [(1r,2s,5r)-5-methyl-2-propan-2-ylcyclohexyl] (2r)-2-hydroxypropanoate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)[C@@H](C)O UJNOLBSYLSYIBM-WISYIIOYSA-N 0.000 claims description 2
- 125000005250 alkyl acrylate group Chemical group 0.000 claims description 2
- 125000005907 alkyl ester group Chemical group 0.000 claims description 2
- BQMNFPBUAQPINY-UHFFFAOYSA-N azane;2-methyl-2-(prop-2-enoylamino)propane-1-sulfonic acid Chemical compound [NH4+].[O-]S(=O)(=O)CC(C)(C)NC(=O)C=C BQMNFPBUAQPINY-UHFFFAOYSA-N 0.000 claims description 2
- 125000002511 behenyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 150000001734 carboxylic acid salts Chemical class 0.000 claims description 2
- TVFJAZCVMOXQRK-UHFFFAOYSA-N ethenyl 7,7-dimethyloctanoate Chemical compound CC(C)(C)CCCCCC(=O)OC=C TVFJAZCVMOXQRK-UHFFFAOYSA-N 0.000 claims description 2
- GADGVXXJJXQRSA-UHFFFAOYSA-N ethenyl 8-methylnonanoate Chemical compound CC(C)CCCCCCC(=O)OC=C GADGVXXJJXQRSA-UHFFFAOYSA-N 0.000 claims description 2
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- 229940041616 menthol Drugs 0.000 claims description 2
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 150000003014 phosphoric acid esters Chemical class 0.000 claims description 2
- 229920002553 poly(2-methacrylolyloxyethyltrimethylammonium chloride) polymer Polymers 0.000 claims description 2
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- VILYDVYHBMHOSG-UHFFFAOYSA-M potassium;2-(methylamino)acetate Chemical class [K+].CNCC([O-])=O VILYDVYHBMHOSG-UHFFFAOYSA-M 0.000 claims description 2
- GZWNUORNEQHOAW-UHFFFAOYSA-M potassium;2-aminoacetate Chemical class [K+].NCC([O-])=O GZWNUORNEQHOAW-UHFFFAOYSA-M 0.000 claims description 2
- GGOZGYRTNQBSSA-UHFFFAOYSA-N pyridine-2,3-diol Chemical compound OC1=CC=CN=C1O GGOZGYRTNQBSSA-UHFFFAOYSA-N 0.000 claims description 2
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- HQCFDOOSGDZRII-UHFFFAOYSA-M sodium;tridecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCOS([O-])(=O)=O HQCFDOOSGDZRII-UHFFFAOYSA-M 0.000 claims description 2
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- AGGIJOLULBJGTQ-UHFFFAOYSA-N sulfoacetic acid Chemical class OC(=O)CS(O)(=O)=O AGGIJOLULBJGTQ-UHFFFAOYSA-N 0.000 claims description 2
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- 239000011149 active material Substances 0.000 claims 1
- 125000003295 alanine group Chemical class N[C@@H](C)C(=O)* 0.000 claims 1
- LVHBHZANLOWSRM-UHFFFAOYSA-N methylenebutanedioic acid Natural products OC(=O)CC(=C)C(O)=O LVHBHZANLOWSRM-UHFFFAOYSA-N 0.000 claims 1
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- DMNPUBKRNRRYMC-UHFFFAOYSA-M potassium;2-hydroxyethanesulfonate Chemical compound [K+].OCCS([O-])(=O)=O DMNPUBKRNRRYMC-UHFFFAOYSA-M 0.000 claims 1
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- XZTJQQLJJCXOLP-UHFFFAOYSA-M sodium;decyl sulfate Chemical compound [Na+].CCCCCCCCCCOS([O-])(=O)=O XZTJQQLJJCXOLP-UHFFFAOYSA-M 0.000 claims 1
- UOWRKHDWHDWJHK-UHFFFAOYSA-M sodium;undecyl sulfate Chemical compound [Na+].CCCCCCCCCCCOS([O-])(=O)=O UOWRKHDWHDWJHK-UHFFFAOYSA-M 0.000 claims 1
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Abstract
本发明涉及一种个人护理组合物,该个人护理组合物包含约12%至约25%的一种或多种表面活性剂;约0.01%至10%的一种或多种可溶性头皮健康活性物质;约0.1%至约4%的增稠聚合物,其中该增稠聚合物选自基于丙烯酸、甲基丙烯酸或其它相关衍生物的均聚物、碱溶胀性和疏水改性的碱溶胀性丙烯酸类共聚物或甲基丙烯酸酯共聚物、可溶性交联丙烯酸类聚合物、缔合聚合物增稠剂以及它们的混合物;0.01%至0.8%的阳离子聚合物;其中个人护理组合物具有约4.5至约6的pH,并且其中个人护理组合物具有小于或等于25的混浊度值。
Description
技术领域
本发明涉及一种个人护理组合物,该个人护理组合物包含表面活性剂、增稠聚合物和阳离子聚合物,从而实现透明外观和低混浊度值。
背景技术
多年来,去头皮屑洗发剂已经广泛用于处理头皮屑以及清洁毛发和头皮,但它们中的大多数看起来不透明或珠光。去头皮屑剂可以是可溶性物质,诸如氯咪巴唑、吡罗克酮乙醇胺或嘧菌酯,并且被称为可溶性头皮健康活性物质。一般来讲,去头皮屑洗发剂由可溶性头皮健康活性物质与旨在将可溶性头皮健康活性物质沉积在头皮上的表面活性剂和含水体系的组合配制。这些体系可以含有阴离子增稠聚合物,以帮助增稠低粘度溶液;以及阳离子聚合物,以帮助改善使用体验。体系中某些阴离子增稠聚合物和阳离子聚合物的组合通常导致不澄清的产物。由于消费者对递送优异去头皮屑功效的澄清去头皮屑洗发剂的需要递增,因此仍然需要一种含有表面活性剂以及阴离子增稠聚合物和阳离子聚合物的洗发剂,其看起来澄清。
已令人惊讶地发现,将特定增稠聚合物添加到含有选择表面活性剂水平、表面活性剂类型和选择阳离子聚合物的洗发剂组合物中将在瓶中和手中看起来澄清。在过去,将类似阳离子聚合物添加到具有特定阴离子聚合物的类似溶液中会产生浑浊、不澄清的组合物。在本发明中已经示出,当阴离子增稠聚合物、阳离子聚合物类型、表面活性剂水平和pH的比率理想时,组合物可以产生澄清配制物。
发明内容
本发明涉及一种个人护理组合物,该个人护理组合物包含约12%至约25%的一种或多种表面活性剂;约0.01%至10%的一种或多种可溶性头皮健康活性物质;约0.1%至约4%的增稠聚合物,其中该增稠聚合物选自基于丙烯酸、甲基丙烯酸或其它相关衍生物的均聚物、碱溶胀性和疏水改性的碱溶胀性丙烯酸类共聚物或甲基丙烯酸酯共聚物、可溶性交联丙烯酸类聚合物、缔合聚合物增稠剂以及它们的混合物;0.01%至0.8%的阳离子聚合物;其中该个人护理组合物具有约4.5至约6的pH,并且其中该个人护理组合物具有小于或等于25的混浊度值。
附图说明
图1是示出阴离子聚合物Carbopol Aqua SF1(具有13%的月桂基聚氧乙烯醚-1硫酸钠(SLE1S)表面活性剂和1%的癸基聚氧乙烯醚-1硫酸钠(C10E1)表面活性剂))对无Carbopol Aqua SF1的图。
图2是示出阴离子聚合物与阳离子聚合物组合的图,其中增加了一些组合物中的阴离子聚合物Carbopol Aqua SF1。
图3是示出阴离子聚合物与阳离子聚合物组合的图,其中增加了一些组合物中的阴离子聚合物Carbopol Aqua SF1。
图4是示出阴离子聚合物与阳离子聚合物组合的图,其中增加了一些组合物中的阴离子聚合物Carbopol Aqua SF1。
图5是展示在总表面活性剂增加和/或癸基聚氧乙烯醚-1硫酸钠(C10E1)表面活性剂增加时透明度增加(混浊度值减小)的图。
图6是展示在总表面活性剂增加和/或癸基聚氧乙烯醚-1硫酸钠(C10E1)表面活性剂增加时透明度增加(混浊度值减小)的图。
图7是展示在总表面活性剂增加和/或癸基聚氧乙烯醚-1硫酸钠(C10E1)表面活性剂增加时透明度增加(混浊度值减小)的图。
图8是展示在总表面活性剂增加和/或癸基聚氧乙烯醚-1硫酸钠(C10E1)表面活性剂增加时透明度增加(混浊度值减小)的图。
图9是展示当pH减小时配制物雾值减小并且看起来更澄清的图。
图10是展示改变阳离子聚合物类型可能影响透明度的图。
图11是展示在添加香料之前将配制物的pH调节到约5.5-5.6的pH改善配制物的混浊度值的图。
图12是展示含有癸基聚氧乙烯醚-1硫酸钠(C10E1)表面活性剂的配制物相对于含有月桂基聚氧乙烯醚-1硫酸钠(SLE1S)的配制物更澄清并且混浊度值更低的图。
具体实施方式
除非另外指明,否则本文中使用的所有百分比和比率均按总组合物的重量计。除非另外指明,所有测量均被理解为是在环境条件下进行,其中“环境条件”是指在约25℃下,在约一个大气压下,并且在约50%相对湿度下的条件。所有数值范围是包括端值在内的更窄的范围;所描述的范围上限和下限是可组合的,以形成没有明确描述的另外的范围。
本发明的组合物可包含本文所述的基本组分以及任选的成分,基本上由其组成或由其组成。如本文所用,“基本上由...组成”是指组合物或组分可包含附加成分,只要附加成分不在本质上改变受权利要求书保护的组合物或方法的基本特征和新颖特征。
如关于组合物所用的“施加”或“施用”是指将本发明的组合物施加或铺展到角质组织诸如毛发上。
“皮肤病学可接受的”是指所述组合物或组分适用于与人的皮肤组织接触,而没有不适当的毒性、不相容性、不稳定性、变应性应答等。
“安全且有效的量”是指足以显著地诱导积极有益效果的化合物或组合物的量。
虽然本说明书以特别指出并清楚地要求保护本发明的权利要求书作为结尾,但据信通过下列说明可更好地理解本发明。
如本文所用,术语“流体”包括液体和凝胶。
如本文所用,当用于权利要求中时,包括“一个”和“一种”的冠词应被理解为是指一种或多种受权利要求书保护或所描述的物质。
如本文所用,“包括/包含”是指可加入不影响最终结果的其它步骤和其它成分。该术语涵盖术语“由……组成”和“基本上由……组成”。
如本文所用,“混合物”旨在包括物质的简单组合以及由它们的组合所可能产生的任何化合物。
如本文所用,除非另外指明,否则“分子量”是指重均分子量。分子量使用工业标准方法、凝胶渗透色谱法(“GPC”)测量。
在给定含量范围的情况下,这些应当被理解为组合物中所述成分的总量,或在多于一种物质落入成分定义的范围内的情况下,组合物中所有成分的总量符合所述定义。
例如,如果组合物包含1%至5%的脂肪醇,则包含2%硬脂醇和1%鲸蜡醇并且没有其它脂肪醇的组合物将落入该范围内。
下文描述的每种特定成分或它们的混合物的量可占个人护理组合物中成分总量的至多100%(或100%)。
如本文所用,“个人护理组合物”包括诸如洗发剂、沐浴凝胶、液体手清洁剂、毛发着色剂、面部清洁剂和其它基于表面活性剂的液体组合物。
如本文所用,术语“包括”、“包含”和“含有”旨在是非限制性的,并且理解为分别是指“具有”、“具备”和“涵盖”。
除非另外说明,否则所有百分比、份数和比率均基于本发明的组合物的总重量。所有涉及所列成分的这些重量均基于活性物质的含量,并且因此不包括可能包含在可商购获得的物质中的载体或副产物。
除非另外指明,否则所有组分或组合物水平均是就该组分或组合物的活性部分而言,且不包括可能存在于此类组分或组合物的可商购获得的来源中的杂质,例如残余溶剂或副产物。
应当理解,贯穿本说明书给出的每一最大数值限度包括每一较低数值限度,如同此类较低数值限度在本文中明确写出。贯穿本说明书给出的每一最小数值限度将包括每一较高数值限度,如同此类较高数值限度在本文中明确写出。贯穿本说明书给出的每一数值范围将包括落在此类较宽数值范围内的每一较窄数值范围,如同此类较窄的数值范围全部在本文中明确写出。
可溶性头皮健康活性物质
可溶性头皮健康活性物质可为选自下列的一种材料或混合物:唑,诸如氯咪巴唑、酮康唑、伊曲康唑、益康唑和康唑;羟基吡啶酮,诸如吡罗克酮乙醇胺、环吡酮、利洛吡司和MEA-羟基辛氧基吡啶酮;角质层分离剂,诸如水杨酸和其它羟基酸;嗜球果伞素,诸如嘧菌酯;以及金属螯合剂,诸如1,10-菲咯啉;以及扁柏酚。
唑类可溶性头皮健康活性物质可以为咪唑,其选自:苯并咪唑、苯并噻唑、联苯苄唑、丁康唑硝酸盐、氯咪巴唑、克霉唑、克鲁康唑、依柏康唑、益康唑、新康唑、芬替康唑、氟康唑、氟三唑、异康唑、酮康唑、兰诺康唑、甲硝唑、咪康唑、奈康唑、奥莫康唑、奥昔康唑硝酸盐、舍他康唑、硝酸硫康唑、噻康唑、噻唑、以及它们的混合物,或所述唑类抗微生物剂为三唑,其选自:特康唑、伊曲康唑、以及它们的混合物。唑可溶性头皮健康活性物质可以是酮康唑。唯一可溶性头皮健康活性物质可以是酮康唑。
可溶性头皮健康活性物质可以约0.01%至10%、约0.1%至约9%、约0.25%至8%、约0.5%至6%、和约0.5%至3%的量存在。可溶性头皮健康活性物质可以是表面活性剂可溶的,并且因此可以是表面活性剂可溶性头皮健康活性物质。
A.去污表面活性剂
个人护理组合物可包含大于约10重量%的向组合物提供清洁性能的表面活性剂体系,并且可以是大于12重量%的向组合物提供清洁性能的表面活性剂体系。表面活性剂体系包含阴离子表面活性剂和/或阴离子表面活性剂的组合和/或阴离子表面活性剂与选自由两性、两性离子、非离子以及它们的混合物组成的组的辅助表面活性剂的组合。去污表面活性剂的各种示例和描述示于美国专利8,440,605;美国专利申请公布2009/155383;和美国专利申请公布2009/0221463中,这些文献全文以引用方式并入本文。
个人护理组合物可包含按重量计约12%至约25%、约12%至约20%;约12%至约18%;约12%至约14%的一种或多种表面活性剂。
适用于组合物中的阴离子表面活性剂为烷基硫酸盐和烷基醚硫酸盐。其它合适的阴离子表面活性剂为有机硫酸反应产物的水溶性盐。其它合适的阴离子表面活性剂为用羟乙磺酸酯化并且用氢氧化钠中和的脂肪酸的反应产物。其它类似的阴离子表面活性剂描述于美国专利2,486,921;2,486,922;和2,396,278中,这些文献全文以引用方式并入本文。
用于个人护理组合物中的示例性阴离子表面活性剂包括月桂基硫酸铵、月桂基聚氧乙烯醚硫酸铵、C10-15烷基聚氧乙烯醚硫酸铵、C10-15烷基硫酸铵、C11-15烷基硫酸铵、癸基硫酸铵、癸基聚氧乙烯醚硫酸铵、十一烷基硫酸铵、十一烷基聚氧乙烯醚硫酸铵、月桂基硫酸三乙胺、月桂基聚氧乙烯醚硫酸三乙胺、月桂基硫酸三乙醇胺、月桂基聚氧乙烯醚硫酸三乙醇胺、月桂基硫酸单乙醇胺、月桂基聚氧乙烯醚硫酸单乙醇胺、月桂基硫酸二乙醇胺、月桂基聚氧乙烯醚硫酸二乙醇胺、月桂酸甘油单酯硫酸钠、月桂基硫酸钠、月桂基聚氧乙烯醚硫酸钠、C10-15烷基聚氧乙烯醚硫酸钠、C10-15烷基硫酸钠、C11-15烷基硫酸钠、癸基硫酸钠、癸基聚氧乙烯醚硫酸钠、十一烷基硫酸钠、十一烷基聚氧乙烯醚硫酸钠、月桂基硫酸钾、月桂基聚氧乙烯醚硫酸钾、C10-15烷基聚氧乙烯醚硫酸钾、C10-15烷基硫酸钾、C11-15烷基硫酸钾、癸基硫酸钾、癸基聚氧乙烯醚硫酸钾、十一烷基硫酸钾、十一烷基聚氧乙烯醚硫酸钾、月桂基肌氨酸钠、月桂酰肌氨酸钠、肌氨酸月桂酯、椰油酰肌氨酸、椰油酰硫酸铵、月桂酰硫酸铵、椰油酰硫酸钠、月桂酰硫酸钠、椰油酰硫酸钾、月桂基硫酸钾、月桂基硫酸三乙醇胺、月桂基硫酸三乙醇胺、椰油酰硫酸单乙醇胺、月桂基硫酸单乙醇胺、十三烷基苯磺酸钠、十二烷基苯磺酸钠、TEA-十二烷基苯磺酸盐、椰油酰羟乙基磺酸钠、椰油酰甲基羟乙基磺酸钠、甲基椰油酰牛磺酸钠、甲基月桂酰牛磺酸钠、癸酰甲基牛磺酸钠、椰油酰谷氨酸钠、椰油酰谷氨酸二钠、辛酰谷氨酸二钠、月桂醇磺基乙酸酯钠、2-磺基月桂酸甲酯钠、2-磺基月桂酸二钠、椰油酰甘氨酸钠、月桂酰甘氨酸钠、以及它们的组合。阴离子表面活性剂可为月桂基硫酸钠或月桂基聚氧乙烯醚硫酸钠。
本发明的组合物还可包含选自以下的阴离子表面活性剂:
a)R1 O(CH2CHR3O)y SO3M;
b)CH3(CH2)z CHR2 CH2 O(CH2 CHR3O)y SO3M;以及
c)它们的混合物,
其中R1表示CH3(CH2)10,R2表示H或烃基团,该烃基团包含1至4个碳原子,使得z和R2中碳原子之和为8,R3为H或CH3,y为0至7,当y不为零(0)时,y的平均值为约1,并且M为一价或二价带正电荷的阳离子。
适宜的阴离子烷基硫酸盐和烷基醚硫酸盐表面活性剂包括但不限于具有支链烷基链的那些,其由可选自以下的C8至C18支链醇合成:格尔伯特醇、羟醛缩合衍生的醇、羰基合成醇、F-T羰基合成醇、以及它们的混合物。2-烷基支链醇的非限制性示例包括:羰基合成醇,诸如2-甲基-1-十一烷醇,2-乙基-1-癸醇,2-丙基-1-壬醇,2-丁基-1-辛醇,2-甲基-1-十二烷醇,2-乙基-1-十一烷醇,2-丙基-1-癸醇,2-丁基-1-壬醇,2-戊基-1-辛醇,2-戊基-1-庚醇,以及以下列商品名出售的那些:(Sasol)、(Sasol)、和(Shell);以及Guerbet和羟醛缩合衍生的醇,诸如2-乙基-1-己醇,2-丙基-1-丁醇,2-丁基-1-辛醇,2-丁基-1-癸醇,2-戊基-1-壬醇,2-己基-1-辛醇,2-己基-1-癸醇和以商品名称(Sasol)出售的那些或作为醇乙氧基化物和烷氧基化物以商品名LUTENSOL(BASF)和LUTENSOL(BASF)出售的那些。
阴离子烷基硫酸盐和烷基醚硫酸盐还可包括由衍生自丁烯或丙烯的C8至C18支链醇合成的那些,其以商品名EXXALTM(Exxon)和(Sasol)出售。这包括十三烷基聚氧乙烯醚-n硫酸钠(STnS)的亚型的阴离子表面活性剂,其中n介于约0.5和约3.5之间。该亚型的示例性表面活性剂是十三烷基聚氧乙烯醚-2硫酸钠和十三烷基聚氧乙烯醚-3硫酸钠。本发明的组合物还可包含十三烷基硫酸钠。
本发明的组合物还可包括阴离子烷基和烷基醚磺基琥珀酸盐和/或二烷基和二烷基醚磺基琥珀酸盐以及它们的混合物二烷基和二烷基醚磺基琥珀酸盐可以为C6-15直链或支链的二烷基或二烷基醚磺基琥珀酸盐。烷基部分可以是对称的(即,相同的烷基部分)或不对称的(即,不同的烷基部分)。非限制性示例包括:月桂基磺基琥珀酸二钠、月桂基聚氧乙烯醚磺基琥珀酸二钠、双十三烷基磺基琥珀酸钠、二辛基磺基琥珀酸钠、二己基磺基琥珀酸钠、二环己基磺基琥珀酸钠、二戊基磺基琥珀酸钠、二异丁基磺基琥珀酸钠、直链双(十三烷基)磺基琥珀酸盐以及它们的混合物。
基本上不含硫酸盐的合适的表面活性剂可包括羟乙基磺酸盐的钠盐、铵盐或钾盐;磺酸盐的钠盐、铵盐或钾盐;醚磺酸盐的钠盐、铵盐或钾盐;磺基琥珀酸盐的钠盐、铵盐或钾盐;磺基乙酸盐的钠盐、铵盐或钾盐;甘氨酸盐的钠盐、铵盐或钾盐;肌氨酸盐的钠盐、铵盐或钾盐;谷氨酸盐的钠盐、铵盐或钾盐;丙氨酸盐的钠盐、铵盐或钾盐;羧酸盐的钠盐、铵盐或钾盐;牛磺酸盐的钠盐、铵盐或钾盐;磷酸酯的钠盐、铵盐或钾盐;以及它们的组合。
如本文所用的“基本上不含”硫酸盐基表面活性剂是指约0重量%至约3重量%、另选地约0重量%至约2重量%、另选地约0重量%至约1重量%、另选地约0重量%至约0.5重量%、另选地约0重量%至约0.25重量%、另选地约0重量%至约0.1重量%、另选地约0重量%至约0.05重量%、另选地约0重量%至约0.01重量%、另选地约0重量%至约0.001重量%,和/或另选地不含硫酸盐。如本文所用,“不含”是指0重量%。
个人护理组合物可包含辅助表面活性剂。辅助表面活性剂可选自两性表面活性剂、两性离子表面活性剂、非离子表面活性剂、以及它们的混合物。辅助表面活性剂可包括但不限于月桂酰胺基丙基甜菜碱、椰油酰胺基丙基甜菜碱、月桂基羟基磺基甜菜碱、月桂酰两性基乙酸钠、椰油酰两性基二乙酸二钠、椰酰胺单乙醇酰胺、以及它们的混合物。
个人护理组合物还可包含约0.25重量%至约15重量%,约1重量%至约14重量%,约2重量%至约13重量%的一种或多种两性、两性离子、非离子辅助表面活性剂、或它们的混合物。
用于本文个人护理组合物中的合适的两性表面活性剂或两性离子表面活性剂包括已知用于个人护理组合物诸如洗发剂或其它个人护理清洁中的那些。合适的两性离子表面活性剂或两性表面活性剂的非限制性示例描述于美国专利5,104,646和5,106,609中,这些文献全文以引用方式并入本文。
适用于组合物中的两性辅助表面活性剂包括被描述为脂族仲胺和叔胺的衍生物的那些表面活性剂,其中脂族基团可为直链或支链,并且其中脂族取代基中的一个含有约8至约18个碳原子,并且一个脂族取代基含有阴离子基团,诸如羧基、磺酸根、硫酸根、磷酸根或膦酸根。合适的两性表面活性剂包括但不限于选自以下的那些:椰油氨基丙酸钠、椰油氨基二丙酸钠、椰油酰两性基乙酸钠、椰油酰两性基二乙酸钠、椰油酰两性基羟丙基磺酸钠、椰油酰两性基丙酸钠、玉米油酰两性基丙酸钠、月桂氨基丙酸钠、月桂酰两性基乙酸钠、月桂酰两性基二乙酸钠、月桂酰两性基羟丙基磺酸钠、月桂酰两性基丙酸钠、玉米油酰两性基丙酸钠、月桂亚氨基二丙酸钠、椰油氨基丙酸铵、椰油氨基二丙酸铵、椰油酰两性基乙酸铵、椰油酰两性基二乙酸铵、椰油酰两性基羟丙基磺酸铵、椰油酰两性基丙酸铵、玉米油酰两性基丙酸铵、月桂氨基丙酸铵、月桂酰两性基乙酸铵、月桂酰两性基二乙酸铵、月桂酰两性基羟丙基磺酸铵、月桂酰两性基丙酸铵、玉米油酰两性基丙酸铵、月桂亚氨基二丙酸铵、椰油氨基丙酸三乙醇胺、椰油氨基二丙酸三乙醇胺、椰油酰两性基乙酸三乙醇胺、椰油酰两性基羟丙基磺酸三乙醇胺、椰油酰两性基丙酸三乙醇胺、玉米油酰两性基丙酸三乙醇胺、月桂氨基丙酸三乙醇胺、月桂酰两性基乙酸三乙醇胺、月桂酰两性基羟丙基磺酸三乙醇胺、月桂酰两性基丙酸三乙醇胺、玉米油酰两性基丙酸三乙醇胺、月桂亚氨基二丙酸三乙醇胺、椰油酰两性基二丙酸、癸酰两性基二乙酸二钠、癸酰两性基二丙酸二钠、辛酰两性基二乙酸二钠、辛酰两性基二丙酸二钠、椰油酰两性基羧乙基羟丙基磺酸二钠、椰油酰两性基二乙酸二钠、椰油酰两性基二丙酸二钠、二羧乙基椰油基丙二胺二钠、月桂基聚氧乙烯醚-5羧基两性基二乙酸二钠、月桂亚氨基二丙酸二钠、月桂酰两性基二乙酸二钠、月桂酰两性基二丙酸二钠、油基两性基二丙酸二钠、PPG-2-异癸醇聚醚-7羧基两性基二乙酸二钠、月桂氨基丙酸、月桂酰两性基二丙酸、月桂基氨基丙基甘氨酸、月桂基二亚乙基二氨基甘氨酸、以及它们的混合物。
组合物可包含两性离子辅助表面活性剂,其中两性离子表面活性剂为脂族季铵、鏻和锍化合物的衍生物,其中脂族基团可为直链或支链,并且其中脂族取代基中的一个含有约8至约18个碳原子,并且一个脂族取代基含有阴离子基团,诸如羧基、磺酸根、硫酸根、磷酸根或膦酸根。两性离子表面活性剂可选自由以下组成的组:椰油酰胺基乙基甜菜碱、椰油酰胺基丙基氧化胺、椰油酰胺基丙基甜菜碱、椰油酰胺基丙基二甲基氨基羟丙基水解胶原、椰油酰胺基丙基二甲基铵羟丙基水解胶原、椰油酰胺基丙基羟基磺基甜菜碱、椰油甜菜碱酰胺基两性基丙酸盐、椰油基甜菜碱、椰油基羟基磺基甜菜碱、椰油基/油基酰胺基丙基甜菜碱、椰油基磺基甜菜碱、月桂酰胺基丙基甜菜碱、月桂基甜菜碱、月桂基羟基磺基甜菜碱、月桂基磺基甜菜碱、以及它们的混合物。
适用于本发明中的非离子表面活性剂包括McCutcheion的“Detergents andEmulsifiers”北美版(1986年,Allured Publishing Corp.)和McCutcheion的“FunctionalMaterials”北美版(1992)中描述的那些。适用于本发明个人护理组合物的非离子表面活性剂包括但不限于聚氧乙烯化烷基酚、聚氧乙烯化醇、聚氧乙烯化聚丙二醇、链烷酸的甘油酯、链烷酸的聚甘油酯、链烷酸的丙二醇酯、链烷酸的山梨醇酯、链烷酸的聚氧乙烯化山梨醇酯、链烷酸的聚氧乙二醇酯、聚氧乙烯化链烷酸、链烷醇酰胺、N-烷基吡咯烷酮、烷基糖苷、烷基多葡糖苷、烷基胺氧化物、和聚氧乙烯化硅氧烷。
辅助表面活性剂可以为非离子表面活性剂,该非离子表面活性剂选自:椰油酰胺、椰油酰胺甲基MEA、椰油酰胺DEA、椰油酰胺MEA、椰油酰胺MIPA、月桂酰胺DEA、月桂酰胺MEA、月桂酰胺MIPA、十四酰胺DEA、十四酰胺MEA、PEG-20椰油酰胺MEA、PEG-2椰油酰胺、PEG-3椰油酰胺、PEG-4椰油酰胺、PEG-5椰油酰胺、PEG-6椰油酰胺、PEG-7椰油酰胺、PEG-3月桂酰胺、PEG-5月桂酰胺、PEG-3油酰胺、PPG-2椰油酰胺、PPG-2羟乙基椰油酰胺、PPG-2羟乙基异硬脂酰胺以及它们的混合物。
代表性的聚氧乙烯化醇包括烷基链在C9-C16范围内,并且具有约1至约110个烷氧基基团的那些,包括但不限于月桂基聚氧乙烯醚-3、月桂基聚氧乙烯醚-23、鲸蜡基聚氧乙烯醚-10、硬脂基聚氧乙烯醚-10、硬脂基聚氧乙烯醚-100、山嵛基聚氧乙烯醚-10、和可以商品名91、23、25、45、135、l 67、PC100、PC 200、PC 600从Shell Chemicals(Houston,Texas)商购获得的那些、以及它们的混合物。
还可商购获得的是可以商品名从Uniqema(Wilmington,Delaware)商购获得的聚氧乙烯脂肪酯,包括但不限于30、35、52、56、58、72、76、78、93、97、98、721、以及它们的混合物。
合适的烷基糖苷和烷基多葡糖苷可由式(S)n-O-R表示,其中S为糖部分诸如葡萄糖、果糖、甘露糖、半乳糖等;n为约1至约1000的整数,并且R为C8-C30烷基基团。烷基基团可衍生自其的长链醇的示例包括癸醇、月桂醇、十四烷醇、鲸蜡醇、硬脂醇、油醇等。这些表面活性剂的示例包括烷基多葡糖苷,其中S为葡萄糖部分,R为C8-20烷基基团,并且n为约1至约9的整数。这些表面活性剂的可商购获得的示例包括以商品名325CS、600CS和625CS)购自Cognis(Ambler,Pa)的癸基多葡糖苷和月桂基多葡糖苷。还可用于本文的是蔗糖酯表面活性剂诸如蔗糖椰油酸酯和蔗糖月桂酸酯、以及以商品名TritonTMBG-10和TritonTMCG-110购自The Dow Chemical Company(Houston,Tx)的烷基多葡糖苷。
适用于本发明的其它非离子表面活性剂为甘油酯和聚甘油酯,其包括但不限于,甘油基单酯,C12-22饱和、不饱和和支链脂肪酸的甘油基单酯如油酸甘油酯、一硬脂酸甘油酯、一棕榈酸甘油酯、一山嵛酸甘油酯、以及它们的混合物,和C12-22饱和、不饱和和支链脂肪酸的聚甘油酯如聚甘油基-4异硬脂酸酯、聚甘油基-3油酸酯、聚甘油基-2-倍半油酸酯、二异硬脂酸三甘油酯、一油酸二甘油酯、一油酸四甘油酯、以及它们的混合物。
还可用作本文的非离子表面活性剂的是脱水山梨糖醇酯。C12-22饱和、不饱和和支链脂肪酸的脱水山梨糖醇酯可用于本文中。这些脱水山梨糖醇酯通常包括单酯、二酯、三酯等的混合物。合适的脱水山梨糖醇酯的代表性示例包括脱水山梨糖醇单月桂酸酯(20)、脱水山梨糖醇单棕榈酸酯(40)、脱水山梨糖醇单硬脂酸酯(60)、脱水山梨糖醇三硬脂酸酯(65)、脱水山梨糖醇单油酸酯(80)、脱水山梨糖醇三油酸酯(85)、和脱水山梨糖醇异硬脂酸酯。
还适用于本文的是脱水山梨糖醇酯的烷氧基化衍生物,包括但不限于均购自Uniqema的聚氧乙烯(20)脱水山梨糖醇单月桂酸酯(20)、聚氧乙烯(20)脱水山梨糖醇单棕榈酸酯(40)、聚氧乙烯(20)脱水山梨糖醇单硬脂酸酯(60)、聚氧乙烯(20)脱水山梨糖醇单油酸酯(80)、聚氧乙烯(4)脱水山梨糖醇单月桂酸酯(21)、聚氧乙烯(4)脱水山梨糖醇单硬脂酸酯(61)、聚氧乙烯(5)脱水山梨糖醇单油酸酯(81)、以及它们的混合物。
还适用于本文的是烷基酚乙氧基化物,包括但不限于壬基酚乙氧基化物(购自TheDow Chemical Company(Houston,Tx.)的TergitolTMNP-4、NP-6、NP-7、NP-8、NP-9、NP-10、NP-11、NP-12、NP-13、NP-15、NP-30、NP-40、NP-50、NP-55、NP-70)以及辛基酚乙氧基化物(购自The Dow Chemical Company(Houston,TX)的TritonTMX-15、X-35、X-45、X-114、X-100、X-102、X-165、X-305、X-405、X-705)。
还适用于本文的是叔烷基胺氧化物,包括月桂基氧化胺和椰油基氧化胺。
适用于个人护理组合物中的其它阴离子、两性离子、两性和非离子附加表面活性剂的非限制性示例描述于McCutcheon的Emulsifiers and Detergents(1989年鉴,由M.C.Publishing Co.)出版和美国专利3,929,678、2,658,072;2,438,091;2,528,378中,这些文献全文以引用方式并入本文。
适宜的表面活性剂组合包含约0.5%至约30%,或者约1%至约25%,或者约2%至约20%的烷基支链的平均重量%。表面活性剂组合可具有约7.5%至约25%,或者约10%至约22.5%,或者约10%至约20%的C8至C12烷基链长度的累积平均重量%。表面活性剂组合可具有约3至约200,或者约25至约175.5,或者约50至约150,或者约75至约125的平均C8-C12/C13-C18烷基链比率。
B.阳离子聚合物
个人护理组合物还包含阳离子聚合物。这些阳离子聚合物可包括以下中的至少一种:(a)阳离子瓜尔胶聚合物,(b)阳离子非瓜尔胶半乳甘露聚糖聚合物,(c)阳离子木薯聚合物,(d)丙烯酰胺单体和阳离子单体的阳离子共聚物,和/或(e)合成的非交联阳离子聚合物,其在与去污表面活性剂组合后可形成或可不形成溶致液晶,(f)阳离子纤维素聚合物。另外,阳离子聚合物可为阳离子聚合物的混合物。
个人护理组合物可包含阳离子瓜尔胶聚合物,其为阳离子取代的半乳甘露聚糖(瓜尔)树胶衍生物。用于制备这些瓜尔胶衍生物的瓜尔胶通常以天然存在的来自瓜尔胶植物种子的材料形式获得。瓜尔胶分子自身为按规则的间隔在交替的甘露糖单元上以单节半乳糖单元支化的直链甘露聚糖。甘露糖单元经由β(1-4)糖苷键连接基彼此连接。经由α(1-6)键,发生半乳糖支化。通过聚半乳甘露聚糖的羟基基团与反应性季铵化合物之间的反应,来获得瓜尔胶的阳离子衍生物。阳离子基团到瓜尔胶结构上的取代度应足以提供上文所述的所需阳离子电荷密度。
阳离子聚合物可包括但不限于阳离子瓜尔胶聚合物,其具有小于2,200,000g/mol、或约150,000至约2,200,000g/mol、或约200,000至约2,200,000g/mol、或约300,000至约1,200,000g/mol、或约750,000至约1,000,000g/mol的重均分子量。阳离子瓜尔胶聚合物可具有约0.2meq/g至约2.2meq/g、或约0.3meq/g至约2.0meq/g、或约0.4meq/g至约1.8meq/g;或约0.5meq/g至约1.8meq/g的电荷密度。
阳离子瓜尔胶聚合物可具有小于约1,500,000g/mol的重均分子量,并且具有约0.1meq/g至约2.5meq/g的电荷密度。阳离子瓜尔胶聚合物可具有小于900,000g/mol、或约150,000g/mol至约800,000g/mol、或约200,000g/mol至约700,000g/mol、或约300,000g/mol至约700,000g/mol、或约400,000g/mol至约600,000g/mol、或约150,000g/mol至约800,000g/mol、或约200,000g/mol至约700,000g/mol、或约300,000g/mol至约700,000g/mol、或约400,000g/mol至约600,000g/mol的重均分子量。阳离子瓜尔胶聚合物可具有约0.2meq/g至约2.2meq/g、或约0.3meq/g至约2.0meq/g、或约0.4meq/g至约1.8meq/g;或约0.5meq/g至约1.5meq/g的电荷密度。
阳离子瓜尔胶聚合物可由季铵化合物形成。用于形成阳离子瓜尔胶聚合物的季铵化合物可符合通式1:
其中R3、R4和R5为甲基或乙基基团;R6为具有通式2的环氧烷基基团:
或R6为具有通式3的卤代醇基团:
其中R7为C1至C3亚烷基;X为氯或溴,并且Z为阴离子,诸如Cl-、Br-、I-或HSO4-。
阳离子瓜尔胶聚合物可符合通式4:
其中R8为瓜尔胶;并且其中R4、R5、R6和R7如上所定义;并且其中Z为卤素。阳离子瓜尔胶聚合物可符合式5:
合适的阳离子瓜尔胶聚合物包括阳离子瓜尔胶衍生物,诸如瓜尔羟丙基三甲基氯化铵。阳离子瓜尔胶聚合物可为瓜尔羟丙基三甲基氯化铵。瓜尔羟丙基三甲基氯化铵的具体示例包括可从Solvay商购获得的系列,例如可从Solvay商购获得的C-500。C-500具有0.8meq/g的电荷密度和500,000g/mol的分子量。其它合适的瓜尔羟丙基三甲基氯化铵为:具有约1.3meq/g的电荷密度和约500,000g/mol的分子量,并且以商品名Optima购自Solvay的瓜尔羟丙基三甲基氯化铵。其它合适的瓜尔羟丙基三甲基氯化铵为:具有约0.7meq/g的电荷密度和约1,500,000g/mol的分子量,并且以商品名Excel购自Solvay的瓜尔羟丙基三甲基氯化铵。其它合适的瓜尔羟丙基三甲基氯化铵为:具有约1.1meq/g的电荷密度和约500,000g/mol的分子量并且购自ASI的瓜尔羟丙基三甲基氯化铵,具有约1.5meq/g的电荷密度和约500,000g/mol的分子量并且购自ASI的瓜尔羟丙基三甲基氯化铵。其它合适的瓜尔羟丙基三甲基氯化铵为:Hi-Care 1000,其具有约0.7meq/g的电荷密度和约600,000g/mol的分子量,并且购自Solvay;N-Hance 3269和N-Hance 3270,其具有约0.7meq/g的电荷密度和约425,000g/mol的分子量,并且购自ASI;N-Hance 3196,其具有约0.8meq/g的电荷密度和约1,100,000g/mol的分子量,并且购自ASI。AquaCat CG518具有约0.9meq/g的电荷密度,和约50,000g/mol的分子量,并且购自ASI。BF-13,其为具有约1meq/g的电荷密度和约800,000的分子量的无硼酸盐(硼)的瓜尔胶,以及BF-17,其为具有约1.5meq/g的电荷密度和约800,000的分子量的无硼酸盐(硼)的瓜尔胶,并且二者均购自ASI。
本发明的个人护理组合物可包含半乳甘露聚糖聚合物衍生物,以单体对单体计,半乳甘露聚糖聚合物衍生物具有的甘露糖与半乳糖的比率大于2:1,半乳甘露聚糖聚合物衍生物选自由以下组成的组:阳离子半乳甘露聚糖聚合物衍生物和具有净正电荷的两性半乳甘露聚糖聚合物衍生物。如本文所用,术语“阳离子半乳甘露聚糖”是指向其中加入阳离子基团的半乳甘露聚糖聚合物。术语“两性半乳甘露聚糖”是指向其中加入阳离子基团和阴离子基团以使得聚合物具有净正电荷的半乳甘露聚糖聚合物。
半乳甘露聚糖聚合物存在于豆科种子胚乳中。半乳甘露聚糖聚合物由甘露糖单体和半乳糖单体的组合构成。半乳甘露聚糖分子为按规则的间隔在特定甘露糖单元上以单节半乳糖单元支化的直链甘露聚糖。甘露糖单元经由β(1-4)糖苷键连接基彼此连接。经由α(1-6)键,发生半乳糖支化。甘露糖单体与半乳糖单体的比率根据植物的品种而改变,并且还受气候的影响。以单体对单体计,本发明非瓜尔胶半乳甘露聚糖聚合物衍生物具有大于2:1的甘露糖与半乳糖的比率。合适的甘露糖与半乳糖的比率可大于约3:1,并且甘露糖与半乳糖的比率可大于约4:1。甘露糖与半乳糖比率的分析是本领域熟知的,并且通常基于半乳糖含量的测量。
用于制备非瓜尔胶半乳甘露聚糖聚合物衍生物的树胶通常以天然存在的材料形式获得,诸如来自植物的种子或豆形果实。各种非瓜尔胶半乳甘露聚糖聚合物的示例包括但不限于塔拉胶(3份甘露糖/1份半乳糖)、刺槐豆胶或角豆胶(4份甘露糖/1份半乳糖)和肉桂胶(5份甘露糖/1份半乳糖)。
非瓜尔胶半乳甘露聚糖聚合物衍生物可具有约1,000至约10,000,000、和/或约5,000至约3,000,000的M.Wt.。
本发明的个人护理组合物还可包含半乳甘露聚糖聚合物衍生物,其具有约0.5meq/g至约7meq/g的阳离子电荷密度。该半乳甘露聚糖聚合物衍生物可具有约1meq/g至约5meq/g的阳离子电荷密度。半乳甘露聚糖结构上的阳离子基团的取代度应足以提供所需的阳离子电荷密度。
半乳甘露聚糖聚合物衍生物可为非瓜尔胶半乳甘露聚糖聚合物的阳离子衍生物,该衍生物由聚半乳甘露聚糖聚合物的羟基基团与反应性季铵化合物之间的反应获得。用于形成阳离子半乳甘露聚糖聚合物衍生物的合适的季铵化合物包括符合如上定义的通式1至5的那些。
由上述试剂形成的阳离子非瓜尔胶半乳甘露聚糖聚合物衍生物由通式6表示:
其中R为树胶。阳离子半乳甘露聚糖衍生物可为树胶羟丙基三甲基氯化铵,其可更具体地由通式7表示:
另选地,半乳甘露聚糖聚合物衍生物可为具有净正电荷的两性半乳甘露聚糖聚合物衍生物,当阳离子半乳甘露聚糖聚合物衍生物还包含阴离子基团时,获得两性半乳甘露聚糖聚合物衍生物。
阳离子非瓜尔胶半乳甘露聚糖可具有大于约4:1的甘露糖与半乳糖的比率,约1,000g/mol至约10,000,000g/mol、和/或约50,000g/mol至约1,000,000g/mol、和/或约100,000g/mol至约900,000g/mol、和/或约150,000g/mol至约400,000g/mol的分子量,以及约1meq/g至约5meq/g、和/或2meq/g至约4meq/g的阳离子电荷密度,并且可来源于肉桂植物。
个人护理组合物可包含水溶性阳离子改性淀粉聚合物。如本文所用,术语“阳离子改性淀粉”是指在使淀粉降解至具有较小分子量之前向其中加入阳离子基团的淀粉,或在使淀粉改性以获得期望的分子量之后向其中加入阳离子基团的淀粉。术语“阳离子改性淀粉”的定义还包括两性改性淀粉。术语“两性改性淀粉”是指向其中加入阳离子基团和阴离子基团的淀粉水解产物。
本文公开的阳离子改性淀粉聚合物具有约0.5%至约4%的结合氮百分比。
用于个人护理组合物中的阳离子改性淀粉聚合物可具有约850,000g/mol至约1,500,000g/mol和/或约900,000g/mol至约1,500,000g/mol的分子量。
个人护理组合物可包含阳离子改性淀粉聚合物,其具有约0.2meq/g至约5meq/g、和/或约0.2meq/g至约2meq/g的电荷密度。获得此类电荷密度的化学改性包括但不限于向淀粉分子中加入氨基和/或铵基团。这些铵基团的非限制性示例可包括取代基,诸如羟丙基三甲基氯化铵、三甲基羟丙基氯化铵、二甲基硬脂基羟丙基氯化铵和二甲基十二烷基羟丙基氯化铵。参见Solarek,D.B.,Cationic Starches in Modified Starches:Propertiesand Uses(Wurzburg,O.B.编辑,CRC Press,Inc.,Boca Raton,Fla.1986,第113-125页)。可将阳离子基团在淀粉降解至具有较小分子量之前加入到淀粉中,或可将阳离子基团在此类改性之后加入到其中。
阳离子改性淀粉聚合物通常具有约0.2至约2.5的阳离子基团取代度。如本文所用,阳离子改性淀粉聚合物的“取代度”是每个由取代基衍生的葡糖酐单元上羟基基团数的平均量度。由于每个葡糖酐单元具有三个可被取代的羟基基团,因此最大可能的取代度为3。以摩尔平均计,取代度表示为每摩尔葡糖酐单元具有的取代基摩尔数。取代度可使用本领域熟知的质子核磁共振光谱(“.sup.1H NMR”)方法来测定。合适的.sup.1H NMR技术包括描述于“Observation on NMR Spectra of Starches in Dimethyl Sulfoxide,Iodine-Complexing,and Solvating in Water-Dimethyl Sulfoxide”,Qin-Ji Peng and ArthurS.Perlin,Carbohydrate Research,160(1987),57-72;和“An Approach to theStructural Analysis of Oligosaccharides by NMR Spectroscopy”,J.HowardBradbury and J.Grant Collins,Carbohydrate Research,71,(1979),15-25中。
在化学改性之前的淀粉来源可选自多种来源,诸如块茎、豆类、谷类和粮食。这种来源的淀粉的非限制性示例可包括玉米淀粉、小麦淀粉、稻米淀粉、蜡质玉米淀粉、燕麦淀粉、木薯淀粉(cassava starch)、蜡质大麦淀粉、蜡质稻米淀粉、麸质稻米淀粉、糯米淀粉、支链淀粉、马铃薯淀粉、木薯淀粉(tapioca starch)、燕麦淀粉、西米淀粉、糯米、或它们的混合物。
阳离子改性淀粉聚合物可选自降解的阳离子玉米淀粉、阳离子木薯、阳离子马铃薯淀粉、以及它们的混合物。另选地,阳离子改性淀粉聚合物为阳离子玉米淀粉和阳离子木薯。
在降解至具有较小分子量之前或在改性至具有较小分子量之后,淀粉可包括一种或多种附加的改性。例如,这些改性可包括交联、稳定化反应、磷酸化和水解。稳定性反应可包括烷基化和酯化。
阳离子改性淀粉聚合物可以水解淀粉(例如酸、酶或碱降解)、氧化淀粉(例如过氧化物、过酸、次氯酸盐、碱或任何其它氧化剂)、物理/机械降解淀粉(例如经由处理设备的热机械能输入)、或它们组合的形式掺入组合物中。
淀粉的最佳形式是一种易于溶解于水中并在水中形成基本上澄清(600nm下约80的透射百分比)溶液的形式。组合物的透明度通过紫外/可见(UV/VIS)分光光度测定法来测定,其使用Gretag Macbeth Colorimeter Color i 5根据相关指导说明,测定样品对UV/VIS光的吸收或透过。已示出,600nm的光波长足以表征化妆品组合物的透明度。
用于个人护理组合物中的合适的阳离子改性淀粉购自已知的淀粉供应商。还适用于个人护理组合物中的是非离子改性淀粉,如本领域所已知的,该非离子改性淀粉可被进一步衍生为阳离子改性淀粉。如本领域已知的是,其他合适的改性淀粉原料可被季铵化以产生适用于个人护理组合物中的阳离子改性淀粉聚合物。
淀粉降解过程:通过在水中混合颗粒状淀粉,可制得淀粉浆液。将温度升至约35℃。然后加入基于淀粉计约50ppm浓度的高锰酸钾水溶液。用氢氧化钠将pH升至约11.5,并且将浆液充分搅拌,以防止淀粉沉降。然后加入在水中稀释的约30%的过氧化氢溶液,使过氧化物的水平基于淀粉计为约1%。然后通过加入附加的氢氧化钠,将pH恢复至约11.5。将反应在约1至约20小时的时段内完成。然后将该混合物用稀盐酸中和。降解淀粉通过过滤接着洗涤并干燥来重新获得。
个人护理组合物可包含丙烯酰胺单体和阳离子单体的阳离子共聚物,其中共聚物具有约1.0meq/g至约3.0meq/g的电荷密度。阳离子共聚物可为丙烯酰胺单体和阳离子单体的合成阳离子共聚物。
阳离子共聚物可包含:
(i)具有下式AM的丙烯酰胺单体:
其中R9为H或C1-4烷基;并且R10和R11独立地选自H、C1-4烷基、CH2OCH3、CH2OCH2CH(CH3)2和苯基,或合在一起为C3-6环烷基;以及
(ii)符合式CM的阳离子单体:
其中k=1,v、v'和v”中的每一者独立地为1至6的整数,w为零或1至10的整数,并且X-为阴离子。
阳离子单体可符合式CM,并且其中k=1,v=3,并且w=0,z=1,并且X-为Cl-,以形成以下结构:
上述结构可被称为二季铵盐。另选地,阳离子单体可符合式CM,并且其中v和v”各自为3,v'=1,w=1,y=1,并且X-为Cl-,诸如:
上述结构可被称为三季铵盐。
合适的丙烯酰胺单体包括但不限于丙烯酰胺或甲基丙烯酰胺。
阳离子共聚物(b)可为AM:TRIQUAT,其为丙烯酰胺和N-[2-[[[二甲基[3-[(2-甲基-1-氧代-2-丙烯基)氨基]丙基]铵基]乙酰基]氨基]乙基]2-羟基-N,N,N',N',N'-五甲基-1,3-丙二铵三氯化物的共聚物。AM:TRIQUAT还被称为聚季铵盐-76(PQ76)。AM:TRIQUAT可具有1.6meq/g的电荷密度和1,100,000g/mol的分子量。
阳离子共聚物可具有丙烯酰胺单体和阳离子单体,其中阳离子单体选自:(甲基)丙烯酸二甲基氨基乙酯、(甲基)丙烯酸二甲基氨基丙酯、(甲基)丙烯酸二叔丁基氨基乙酯、二甲基氨甲基(甲基)丙烯酰胺、二甲基氨丙基(甲基)丙烯酰胺;乙烯亚胺、乙烯胺、2-乙烯基吡啶、4-乙烯基吡啶;(甲基)丙烯酸三甲基氯化铵乙酯、(甲基)丙烯酸三甲基甲基硫酸铵乙酯、(甲基)丙烯酸二甲基苄基氯化铵乙酯、丙烯酸4-苯甲酰基苄基二甲基氯化铵乙酯、三甲基氯化铵乙基(甲基)丙烯酰胺、三甲基氯化铵丙基(甲基)丙烯酰胺、乙烯基苄基三甲基氯化铵、二烯丙基二甲基氯化铵、以及它们的混合物。
阳离子共聚物可包含阳离子单体,该阳离子单体选自:阳离子单体包括(甲基)丙烯酸三甲基氯化铵乙酯、(甲基)丙烯酸三甲基甲基硫酸铵乙酯、(甲基)丙烯酸二甲基苄基氯化铵乙酯、丙烯酸4-苯甲酰基苄基二甲基氯化铵乙酯、三甲基氯化铵乙基(甲基)丙烯酰胺、三甲基氯化铵丙基(甲基)丙烯酰胺、乙烯基苄基三甲基氯化铵、以及它们的混合物。
阳离子共聚物可为水溶性的。阳离子共聚物由以下形成:(1)(甲基)丙烯酰胺和基于(甲基)丙烯酰胺的阳离子单体和/或水解稳定的阳离子单体的共聚物,(2)(甲基)丙烯酰胺、基于阳离子(甲基)丙烯酸酯的单体、和基于(甲基)丙烯酰胺的单体、和/或水解稳定的阳离子单体的三聚物。基于阳离子(甲基)丙烯酸酯的单体可为含有季铵化N原子的(甲基)丙烯酸的阳离子化酯。含有季铵化N原子的(甲基)丙烯酸的阳离子化酯可为在烷基和亚烷基基团中具有C1至C3的季铵化(甲基)丙烯酸二烷基氨基烷基酯。合适的含有季铵化N原子的(甲基)丙烯酸的阳离子化酯可选自:用氯甲烷季铵化的(甲基)丙烯酸二甲基氨基甲酯的铵盐、(甲基)丙烯酸二甲基氨基乙酯的铵盐、(甲基)丙烯酸二甲基氨基丙酯的铵盐、(甲基)丙烯酸二乙基氨基甲酯的铵盐、(甲基)丙烯酸二乙基氨基乙酯的铵盐;以及(甲基)丙烯酸二乙基氨基丙酯的铵盐。包含季铵化的N原子的(甲基)丙烯酸的阳离子化酯可为用卤代烷、或用氯甲烷、或苄基氯、或硫酸二甲酯季铵化的丙烯酸二甲基氨基乙酯(ADAME-Quat)。当基于(甲基)丙烯酰胺时,阳离子单体可为在烷基和亚烷基基团中具有C1至C3的季铵化二烷基氨基烷基(甲基)丙烯酰胺,或者用卤代烷、或氯甲烷、或苄基氯、或硫酸二甲酯季铵化的二甲基氨基丙基丙烯酰胺。
合适的基于(甲基)丙烯酰胺的阳离子单体包括在烷基和亚烷基基团中具有C1至C3的季铵化二烷基氨基烷基(甲基)丙烯酰胺。基于(甲基)丙烯酰胺的阳离子单体可为二甲基氨基丙基丙烯酰胺,其用卤代烷(尤其是氯甲烷)或苄基氯或硫酸二甲酯季铵化。
阳离子单体可为水解稳定的阳离子单体。除了二烷基氨基烷基(甲基)丙烯酰胺以外,水解稳定的阳离子单体还可为OECD水解测试可以认为稳定的所有单体。阳离子单体可为水解稳定的,并且水解稳定的阳离子单体可选自:二烯丙基二甲基氯化铵和水溶性阳离子苯乙烯衍生物。
阳离子共聚物可为丙烯酰胺、用氯甲烷季铵化的(甲基)丙烯酸2-二甲基铵乙酯(ADAME-Q)、和用氯甲烷季铵化的3-二甲基铵丙基(甲基)丙烯酰胺(DIMAPA-Q)的三元共聚物。阳离子共聚物可由丙烯酰胺和丙烯酰胺基丙基三甲基氯化铵形成,其中丙烯酰胺基丙基三甲基氯化铵具有约1.0meq/g至约3.0meq/g的电荷密度。
阳离子共聚物可具有约1.1meq/g至约2.5meq/g、或约1.1meq/g至约2.3meq/g、或约1.2meq/g至约2.2meq/g、或约1.2meq/g至约2.1meq/g、或约1.3meq/g至约2.0meq/g、或约1.3meq/g至约1.9meq/g的电荷密度。
阳离子共聚物可具有约100,000g/mol至约1,500,000g/mol、或约300,000g/mol至约1,500,000g/mol、或约500,000g/mol至约1,500,000g/mol、或约700,000g/mol至约1,000,000g/mol、或约900,000g/mol至约1,200,000g/mol的分子量。
阳离子共聚物可以为三甲基铵丙基甲基丙烯酰胺氯化物-N-丙烯酰胺共聚物,其还被称为AM:MAPTAC。AM:MAPTAC可具有约1.3meq/g的电荷密度和约1,100,000g/mol的分子量。阳离子共聚物可以为AM:ATPAC。AM:ATPAC可具有约1.8meq/g的电荷密度和约1,100,000g/mol的分子量。
(a)阳离子合成聚合物
个人护理组合物可包含可由以下形成的阳离子合成聚合物
i)一种或多种阳离子单体单元,和任选地
ii)一种或多种带有负电荷的单体单元,和/或
iii)非离子单体,其中共聚物的随后电荷是正的。三种类型的单体的比率以“m”、“p”和“q”给出,其中“m”为阳离子单体的数目,“p”为带有负电荷的单体的数目,并且“q”为非离子单体的数目
阳离子聚合物可为具有以下结构的水溶性或水可分散的非交联并且合成的阳离子聚合物:
其中A可为以下阳离子部分中的一种或多种:
其中@=酰胺基、烷基酰胺基、酯、醚、烷基、或烷基芳基;
其中Y=C1-C22烷基、烷氧基、烷叉基、烷基、或芳氧基;
其中ψ=C1-C22烷基、烷氧基、烷基芳基、或烷基芳氧基;。
其中Z=C1-C22烷基、烷氧基、芳基、或芳氧基;
其中R1=H、C1-C4直链或支链烷基;
其中s=0或1,n=0或≥1;
其中T和R7=C1-C22烷基;以及
其中X-=卤素、氢氧根、链烷醇根、硫酸根或烷基硫酸根。
其中带有负电荷的单体由以下定义:R2'=H、C1-C4直链或支链烷基,并且R3为:
其中D=O、N、或S;
其中Q=NH2或O;
其中u=1至6;
其中t=0至1;以及
其中J=含有以下元素P、S、C的氧化官能团。
其中非离子单体由以下定义:R2”=H、C1-C4直链或支链烷基,R6=直链或支链烷基、烷基芳基、芳氧基、烷氧基、烷基芳氧基,并且β定义为
其中G‘和G”彼此独立地为O、S或N-H,并且L=0或1。
阳离子单体的示例包括(甲基)丙烯酸氨基烷基酯、(甲基)氨基烷基(甲基)丙烯酰胺;包含至少一个仲、叔或季铵官能团,或含有氮原子的杂环基团、乙烯胺或乙烯亚胺的单体;二烯丙基二烷基铵盐;它们的混合物、它们的盐以及从它们衍生出的大分子单体。
阳离子单体的另外示例包括(甲基)丙烯酸二甲基氨基乙酯、(甲基)丙烯酸二甲基氨基丙酯、(甲基)丙烯酸二叔丁基氨基乙酯、二甲基氨基甲基(甲基)丙烯酰胺、二甲基氨基丙基(甲基)丙烯酰胺、乙烯亚胺、乙烯胺、2-乙烯基吡啶、4-乙烯基吡啶、(甲基)丙烯酸三甲基氯化铵乙酯、(甲基)丙烯酸三甲基甲基硫酸铵乙酯、(甲基)丙烯酸二甲基苄基氯化铵乙酯、丙烯酸4-苯甲酰基苄基二甲基氯化铵乙酯、三甲基氯化铵乙基(甲基)丙烯酰胺、三甲基氯化铵丙基(甲基)丙烯酰胺、乙烯基苄基三甲基氯化铵、二烯丙基二甲基氯化铵。
合适的阳离子单体包括包含式-NR3 +的季铵基团的那些,其中R相同或不同,代表氢原子、包含1至10个碳原子的烷基基团,或苄基基团,任选地带有羟基基团,并且包括阴离子(抗衡离子)。阴离子的示例为卤离子(诸如氯离子、溴离子)、硫酸根、硫酸氢根、烷基硫酸根(例如,包含1至6个碳原子)、磷酸根、柠檬酸根、甲酸根和乙酸根。
合适的阳离子单体包括(甲基)丙烯酸三甲基氯化铵乙酯、(甲基)丙烯酸三甲基甲基硫酸铵乙酯、(甲基)丙烯酸二甲基苄基氯化铵乙酯、丙烯酸4-苯甲酰基苄基二甲基氯化铵乙酯、三甲基氯化铵乙基(甲基)丙烯酰胺、三甲基氯化铵丙基(甲基)丙烯酰胺、乙烯基苄基三甲基氯化铵。
附加合适的阳离子单体包括三甲基氯化铵丙基(甲基)丙烯酰胺。
带有负电荷的单体的示例包括包含磷酸根或膦酸根基团的α-烯键式不饱和单体、α-烯键式不饱和一元羧酸、α-烯键式不饱和二元羧酸的单烷基酯、α-烯键式不饱和二元羧酸的单烷基酰胺、包含磺酸基团的α-烯键式不饱和化合物、以及包含磺酸基团的α-烯键式不饱和化合物的盐。
具有负电荷的合适单体包括丙烯酸、甲基丙烯酸、乙烯基磺酸、乙烯基磺酸的盐、乙烯基苯磺酸、乙烯基苯磺酸的盐、α-丙烯酰胺基甲基丙磺酸、α-丙烯酰胺基甲基丙磺酸的盐、甲基丙烯酸2-磺基乙酯、甲基丙烯酸2-磺基乙酯的盐、丙烯酰胺基-2-甲基丙磺酸(AMPS)、丙烯酰胺基-2-甲基丙磺酸的盐、以及苯乙烯磺酸盐(SS)。
非离子单体的示例包括乙酸乙烯酯、α-烯键式不饱和羧酸的酰胺、具有氢化或氟化醇的α-烯键式不饱和一元羧酸的酯、聚环氧乙烷(甲基)丙烯酸酯(即,聚乙氧基化的(甲基)丙烯酸)、α-烯键式不饱和二元羧酸的单烷基酯、α-烯键式不饱和二元羧酸的单烷基酰胺、乙烯基腈、乙烯胺酰胺、乙烯醇、乙烯基吡咯烷酮和乙烯基芳族化合物。
合适的非离子单体包括苯乙烯、丙烯酰胺、甲基丙烯酰胺、丙烯腈、丙烯酸甲酯、丙烯酸乙酯、丙烯酸正丙酯、丙烯酸正丁酯、甲基丙烯酸甲酯、甲基丙烯酸乙酯、甲基丙烯酸正丙酯、甲基丙烯酸正丁酯、丙烯酸2-乙基-己酯、甲基丙烯酸2-乙基-己酯、丙烯酸2-羟乙酯和甲基丙烯酸2-羟乙酯。
与合成阳离子聚合物缔合的阴离子抗衡离子(X-)可为任何已知的抗衡离子,只要聚合物在水中、在个人护理组合物中、或在个人护理组合物中的凝聚层相中保持可溶解或可分散,并且只要抗衡离子在物理和化学上与个人护理组合物的基本组分相容,或不以其它方式不当地破坏产品的性能、稳定性或美观性。此类抗衡离子的非限制性示例包括卤离子(例如,氯、氟、溴、碘)、硫酸根和甲硫酸根。
本文所述的阳离子聚合物可有助于向受损毛发,尤其是经化学处理的毛发提供替代疏水性F层。极薄的F-层在提供天然耐候性的同时有助于密封水分并防止进一步损伤。化学处理会损伤毛发表皮并且使其保护性F-层剥离。当F-层被剥离时,毛发变得日益亲水。已发现,当溶致液晶被施用到化学处理过的毛发上时,毛发在外观和感觉两者上变得更加疏水且更像天然的。不受任何理论所束缚,据信该溶致液晶复合物形成疏水层或膜,其覆盖毛发纤维并且保护毛发,如同天然的F-层保护毛发那样。疏水层恢复毛发成通常像未处理的、更健康的状态。溶致液晶通过将本文所述的合成阳离子聚合物与前述个人护理组合物的阴离子去污表面活性剂组分混合来形成。合成阳离子聚合物具有相对高的电荷密度。应当指出,一些具有相对高阳离子电荷密度的合成聚合物不形成溶致液晶,这主要是由于它们不正常的直链电荷密度。此类合成阳离子聚合物描述于授予Reich等人的WO 94/06403中。本文所述的合成聚合物可配制于稳定的个人护理组合物中,该个人护理组合物针对受损毛发提供改善的调理性能。
可形成溶致液晶的阳离子合成聚合物具有约2meq/gm至约7meq/gm,和/或约3meq/gm至约7meq/gm,和/或约4meq/gm至约7meq/gm的阳离子电荷密度。阳离子电荷密度可以为约6.2meq/gm。聚合物还具有约1,000至约5,000,000、和/或约10,000至约1,500,000、和/或约100,000至约1,500,000的M.Wt.。
在本发明中,提供增强的调理性和有益剂沉积但无需形成溶致液晶的阳离子合成聚合物可具有约0.7meq/gm至约7meq/gm,和/或约0.8meq/gm至约5meq/gm,和/或约1.0meq/gm至约3meq/gm的阳离子电荷密度。聚合物还可具有约1,000至约1,500,000、约10,000至约1,500,000和约100,000至约1,500,000的M.Wt.。
合适的阳离子纤维素聚合物为羟乙基纤维素与三甲基铵取代的环氧化物反应所得的盐,其在工业(CTFA)上被称为聚季铵盐-10,并且以它们的Polymer LR、JR和KG聚合物系列购自Dow/Amerchol Corp.(Edison,N.J.,USA)。非限制性示例包括:JR-30M、JR-400、KG-30M、JP、LR-30M、LR-400、以及它们的混合物。阳离子纤维素的其它合适类型包括羟乙基纤维素与月桂基二甲基铵取代的环氧化物反应所得的聚合季铵盐,其在工业(CTFA)上被称为聚季铵盐-24。这些材料以商品名Polymer LM-200购自Dow/Amerchol Corp.。其它合适类型的阳离子纤维素包括羟乙基纤维素与月桂基二甲基铵取代的环氧化物以及三甲基铵取代的环氧化物反应所得的聚合季铵盐,其在工业(CTFA)上被称为聚季铵盐-67。这些材料以商品名SoftCAT Polymer SL-5、SoftCAT Polymer SL-30、Polymer SL-60、Polymer SL-100、Polymer SK-L、Polymer SK-M、Polymer SK-MH、和Polymer SK-H购自Dow/AmercholCorp.。
阳离子聚合物的浓度按个人护理组合物的重量计在约0.025%至约5%、约0.1%至约3%、和/或约0.2%至约1%的范围内。
增稠聚合物
个人护理组合物可包含增稠聚合物以增加组合物的粘度。可使用适宜的增稠聚合物。个人护理组合物可包含约0.5%至约10%的增稠聚合物,约0.1%至约4%的增稠聚合物,约0.5%至约2%的增稠聚合物,和约0.7%至约1%的增稠聚合物。增稠聚合物改性剂可以为聚丙烯酸酯、聚丙烯酰胺增稠剂。增稠聚合物可以为阴离子增稠聚合物。
个人护理组合物可包含增稠聚合物,该增稠聚合物是基于丙烯酸、甲基丙烯酸或其他相关的衍生物的均聚物,非限制性示例包括聚丙烯酸酯、聚甲基丙烯酸酯、聚乙基丙烯酸酯和聚丙烯酰胺。
增稠聚合物可为碱溶胀性和疏水改性的碱溶胀性丙烯酸类共聚物或甲基丙烯酸酯共聚物,非限制性示例包括丙烯酸/丙烯腈共聚物、丙烯酸酯/硬脂基聚氧乙烯醚-20衣康酸酯共聚物、丙烯酸酯/鲸蜡基聚氧乙烯醚-20衣康酸酯共聚物、丙烯酸酯/氨基丙烯酸酯/C10-30烷基PEG-20衣康酸酯共聚物、丙烯酸酯/氨基丙烯酸酯共聚物、丙烯酸酯/硬脂基聚氧乙烯醚-20甲基丙烯酸酯共聚物、丙烯酸酯/山嵛基聚氧乙烯醚-25甲基丙烯酸酯共聚物、丙烯酸酯/硬脂基聚氧乙烯醚-20甲基丙烯酸酯交联聚合物、丙烯酸酯/山嵛基聚氧乙烯醚-25甲基丙烯酸酯/HEMA交联聚合物、丙烯酸酯/新癸酸乙烯酯交联聚合物、丙烯酸酯/异癸酸乙烯酯交联聚合物、丙烯酸酯/棕榈油醇聚醚-25丙烯酸酯共聚物、丙烯酸/丙烯酰胺基甲基丙烷磺酸共聚物、以及丙烯酸酯/丙烯酸C10-C30烷基酯交联聚合物。
增稠聚合物可以是可溶性交联丙烯酸类聚合物,非限制性示例包括卡波姆。
增稠聚合物可为缔合聚合物增稠剂,非限制性示例包括:疏水改性的碱溶胀性乳液,非限制性示例包括疏水改性的聚丙烯酸酯;疏水改性的聚丙烯酸和疏水改性的聚丙烯酰胺;疏水改性的聚醚,其中这些材料可具有选自鲸蜡基、硬脂基、油酰基、以及它们的组合的疏水物。
增稠聚合物可与聚乙烯吡咯烷酮、交联的聚乙烯吡咯烷酮和衍生物组合使用。增稠聚合物可与聚乙烯醇和衍生物组合。增稠聚合物可与聚乙烯亚胺和衍生物组合。
增稠聚合物可与基于藻酸的材料组合,非限制性示例包括藻酸钠和藻酸丙二醇酯。
增稠聚合物可与聚氨基甲酸酯聚合物组合使用,非限制性示例包括:疏水改性的烷氧基化氨基甲酸酯聚合物,非限制性示例包括PEG-150/癸醇/SMDI共聚物、PEG-150/硬脂醇/SMDI共聚物、聚氨基甲酸酯-39。
增稠聚合物可与缔合聚合物增稠剂组合,非限制性示例包括:疏水改性的纤维素衍生物;以及具有10-300、30-200和40-150个重复单元的环氧乙烷重复基团的亲水部分。该类型的非限制性示例包括PEG-120-甲基葡萄糖二油酸酯、PEG–(40或60)脱水山梨糖醇四油酸酯、PEG-150季戊四醇四硬脂酸酯、PEG-55丙二醇油酸酯、PEG-150二硬脂酸酯。
增稠聚合物可与纤维素和衍生物组合,非限制性示例包括微晶纤维素、羧甲基纤维素、羟乙基纤维素、羟丙基纤维素、羟丙基甲基纤维素、甲基纤维素、乙基纤维素;硝基纤维素;纤维素硫酸盐;纤维素粉末;疏水改性的纤维素。
增稠聚合物可与瓜尔胶和瓜尔胶衍生物组合,非限制性示例包括羟丙基瓜尔胶和羟丙基瓜尔胶羟丙基三甲基氯化铵。
增稠聚合物可与聚环氧乙烷;聚环氧丙烷;以及POE-PPO共聚物。
增稠聚合物可与由以下通式表征的聚亚烷基二醇组合:
其中R为氢、甲基、或它们的混合物,优选地氢,并且n为具有2,000-180,000、或7,000-90,000、或7,000-45,000的平均数的整数。这种类型的非限制性示例包括PEG-7M、PEG-14M、PEG-23M、PEG-25M、PEG-45M、PEG-90M、或PEG-100M。
增稠聚合物可与水溶胀性粘土组合,非限制性示例包括合成锂皂石、膨润土、蒙脱石、绿土和锂蒙脱石。
增稠聚合物可与树胶组合,非限制性示例包括黄原胶、瓜尔胶、羟丙基瓜尔胶、阿拉伯胶、黄蓍胶、半乳聚糖、长豆角胶、刺梧桐树胶和刺槐豆胶。
增稠聚合物可与以下物质组合:二亚苄基山梨醇、卡拉根、果胶、琼脂、温柏树籽(榅桲子)、淀粉(来自稻米、玉米、马铃薯、小麦等)、淀粉衍生物(例如羧甲基淀粉、甲基羟丙基淀粉)、藻类提取物、右旋糖酐、琥珀酰葡聚糖和pulleran。
增稠聚合物的非限制性示例包括丙烯酰胺/丙烯酸铵共聚物(和)聚异丁烯(和)聚山梨酸酯20;丙烯酰胺/丙烯酰二甲基牛磺酸钠共聚物/异十六烷/聚山梨酸酯80、丙烯酰二甲基牛磺酸铵/VP共聚物、丙烯酸钠/丙烯酰二甲基牛磺酸钠共聚物、丙烯酸酯共聚物、丙烯酸酯交联聚合物-4、丙烯酸酯交联聚合物-3、丙烯酸酯/山嵛基聚氧乙烯醚-25甲基丙烯酸酯共聚物、丙烯酸酯/丙烯酸C10-C30烷基酯交联聚合物、丙烯酸酯/硬脂基聚氧乙烯醚-20衣康酸酯共聚物、聚丙烯酸铵/异十六烷/PEG-40蓖麻油;卡波姆、卡波姆钠、交联的聚乙烯吡咯烷酮(PVP)、聚丙烯酰胺/C13-14异链烷烃/月桂基聚氧乙烯醚-7、聚丙烯酸酯13/聚异丁烯/聚山梨酸酯20、聚丙烯酸酯交联聚合物-6、聚酰胺-3、聚季铵盐-37(和)氢化聚癸烯(和)十三烷基聚氧乙烯醚-6、丙烯酰胺/丙烯酰基二甲基牛磺酸钠/丙烯酸共聚物、丙烯酸钠/丙烯酰基二甲基牛磺酸盐/二甲基丙烯酰胺、交联聚合物(和)异十六烷(和)聚山梨酸酯60、聚丙烯酸钠。示例性可商购获得的增稠聚合物包括:ACULYNTM28、ACULYNTM88、ACULYNTM33、ACULYNTM22、ACULYNTMExcel、Aqua SF-1、ETD 2020、Ultrez 20、Ultrez 21、Ultrez 10、Ultrez 30、1342、Aqua SF-2聚合物、SepigelTM305、SimulgelTM600、Sepimax Zen、SMART 1000、TTA、SC-Plus、PLUS、AVC、Stabylen 30、以及它们的组合。
1.水混溶性溶剂
个人护理组合物可包含水并且可用于本文的多元醇的非限制性示例包括丙二醇、二丙二醇、丁二醇、己二醇、甘油、丙二醇、以及它们的混合物。
在本发明中,个人护理组合物可包含水溶助长剂/粘度调节剂,其为低级烷基苯磺酸盐的碱金属盐或铵盐,诸如二甲苯磺酸钠、异丙基苯磺酸钠或甲苯磺酸钠。
C.头皮健康剂
在本发明中,除了通过可溶性头皮健康活性物质提供的可溶性头皮健康活性物质功效之外,还可添加一种或多种头皮健康剂以提供头皮有益效果。该组物质是变化的,并且提供广泛范围的有益效果,包括保湿、阻隔改善、抗真菌、抗微生物和抗氧化剂、抗痒和感觉剂。此类头皮健康剂包括但不限于:维生素E和F、水杨酸、烟酰胺、咖啡因、泛醇、二醇、乙醇酸、PCA、PEG、赤藓醇、甘油、三氯生、乳酸酯、透明质酸酯、尿囊素和其它脲、甜菜碱、山梨醇、谷氨酸酯、木糖醇、薄荷醇、乳酸薄荷酯、异环酮、苄醇、包含以下结构的化合物:
R1选自H、烷基、氨基烷基、烷氧基;
Q=H2、O、-OR1、-N(R1)2、-OPO(OR1)x、-PO(OR1)x、-P(OR1)x,其中x=1-2;
V=NR1、O、-OPO(OR1)x、-PO(OR1)x、-P(OR1)x,其中x=1-2;
W=H2、O;
对于n=0,X、Y=独立地选自H、芳基、萘基;
对于n≥1,X、Y=脂族CH2或芳族CH,并且Z选自脂族CH2、芳族CH或杂原子;
A=低级烷氧基、低级烷硫基、芳基、取代的芳基或稠合芳基;以及
立体化学能够在标记*的位置处变化。
以及天然提取物/油,包括薄荷油、留兰香、摩洛哥坚果油、霍霍巴油和芦荟。
D.任选成分
在本发明中,个人护理组合物还可包含一种或多种任选成分,包括有益剂。合适的有益剂包括但不限于调理剂、阳离子聚合物、有机硅乳液、去头皮屑剂、螯合剂、以及天然油脂诸如葵花油或蓖麻油。另外合适的任选成分包括但不限于香料、香料微胶囊、着色剂、颗粒、抗微生物剂、泡沫抑制剂、抗静电剂、流变改性剂和增稠剂、悬浮材料和结构剂、pH调节剂和缓冲剂、防腐剂、珠光剂、溶剂、稀释剂、抗氧化剂、维生素、以及它们的组合。在本发明中,香料可以约0.5%至约7%存在。
此类任选成分应在物理和化学上与组合物的组分相容,并且不应以其它方式不当地破坏产品的稳定性、美观性或性能。《CTFA Cosmetic Ingredient Handbook》第十版(由Cosmetic、Toiletry和Fragrance Association公司公布,华盛顿)(2004)(下文称为“CTFA”)描述了各种各样可加入到本文组合物中的非限制性材料。
1.调理剂
个人护理组合物的调理剂可为有机硅调理剂。有机硅调理剂可包含挥发性有机硅、非挥发性有机硅、或它们的组合。有机硅调理剂的浓度通常在按组合物的重量计约0.01%至约10%、约0.1%至约8%、约0.1%至约5%、和/或约0.2%至约3%的范围内。合适的有机硅调理剂和用于有机硅的任选悬浮剂的非限制性示例描述于美国再公告专利34,584、美国专利5,104,646和美国专利5,106,609中,这些专利以引用方式并入本文。
用于本发明组合物中的有机硅调理剂可具有如在25C下测量的约20至约2,000,000厘沲("csk")、约1,000至约1,800,000csk、约10,000至约1,500,000csk、和/或约20,000至约1,500,000csk的粘度。
分散的有机硅调理剂颗粒通常具有在约0.01微米至约0.10微米范围内的体积平均粒径。对于施用于毛发的小颗粒,体积平均粒径通常在约0.01微米至约0.10微米、约0.01微米至约0.60微米、约0.01微米至约0.30微米的范围内。
包括论述有机硅流体、硅橡胶纯胶料和有机硅树脂以及有机硅制造的各章节在内的有关有机硅的附加资料可参见Encyclopedia of Polymer Science and Engineering,第15卷,第2版,第204-308页,John Wiley&Sons,Inc.(1989),该文献以引用方式并入本文。
适用于本发明的有机硅乳液可包括但不限于根据美国专利6,316,541或美国专利4,476,282或美国专利申请公布2007/0276087中提供的描述制得的不溶性聚硅氧烷乳液。因此,合适的不溶性聚硅氧烷包括聚硅氧烷,诸如α,ω-羟基封端的聚硅氧烷或α,ω-烷氧基封端的聚硅氧烷,其具有约5csk至约500,000csk的内相粘度。例如,不溶性聚硅氧烷可具有小于400,000csk,优选地小于200,000csk,更优选地约10,000csk至约180,000csk的内相粘度。不溶性聚硅氧烷可具有在以下范围内的平均粒度:小于约100nm;约10nm至约100nm。平均粒度可在约15nm至约60微米,或约30nm至约50nm的范围内。
不溶性聚硅氧烷的平均分子量、不溶性聚硅氧烷的内相粘度、有机硅乳液的粘度、和包含不溶性聚硅氧烷的颗粒的尺寸由本领域技术人员常用的方法测定,诸如公开于Smith,A.L.的The Analytical Chemistry of Silicones,John Wiley&Sons,Inc.:NewYork,1991中的方法。例如,有机硅乳液的粘度可在30℃下用Brookfield粘度计和锭子6以2.5rpm来测量。有机硅乳液还可包括附加乳化剂以及阴离子表面活性剂。
适用于本发明组合物中的其它类型的有机硅包括但不限于:i)有机硅流体,包括但不限于有机硅油,其为具有如在25℃下测量的小于约1,000,000csk的粘度的可流动材料;ii)氨基硅氧烷,该氨基硅氧烷包含至少一个伯胺、仲胺或叔胺;iii)阳离子有机硅,该阳离子有机硅包含至少一个季铵官能团;iv)硅橡胶纯胶料;该硅橡胶纯胶料包括具有在25℃测量的大于或等于1,000,000csk的粘度的材料;v)有机硅树脂,该有机硅树脂包括高度交联的聚合硅氧烷体系;vi)高折射率有机硅,该高折射率有机硅具有至少1.46的折射率,以及vii)它们的混合物。
本发明的个人护理组合物的调理剂还可包含单独或与其他调理剂诸如上述有机硅组合的至少一种有机调理材料诸如油或蜡。有机材料可以是非聚合的、低聚的或聚合的。它可为油或蜡的形式,并且可以纯制剂或以预乳化形式添加。有机调理材料的一些非限制性示例包括但不限于:i)烃油;ii)聚烯烃;iii)脂肪酯;iv)氟化调理化合物;v)脂肪醇;vi)烷基葡糖苷和烷基葡糖苷衍生物;vii)季铵化合物;viii)具有至多约2,000,000的分子量的聚乙二醇和聚丙二醇,包括具有CTFA名称PEG-200、PEG-400、PEG-600、PEG-1000、PEG-2M、PEG-7M、PEG-14M、PEG-45M的那些、以及它们的混合物。
2.乳化剂
在本发明的个人护理组合物中可使用多种阴离子和非离子乳化剂。阴离子和非离子乳化剂在性质上可为单体或聚合物。例如,单体示例包括但不限于烷基乙氧基化物、烷基硫酸盐、皂和脂肪酸酯、以及它们的衍生物。经由说明并不受限制,聚合物的示例包括聚丙烯酸酯、聚乙二醇和嵌段共聚物、以及它们的衍生物。天然存在的乳化剂如羊毛脂、卵磷脂和木质素以及它们的衍生物也是可用乳化剂的非限制性示例。
3.螯合剂
个人护理组合物还可包含螯合剂。合适的螯合剂包括A E Martell&RM Smith的Critical Stability Constants第1卷(Plenum Press,New York&London(1974))和A EMartell&R D Hancock的Metal Complexes in Aqueous Solution(Plenum Press,NewYork&London(1996))中所列的那些,将两篇文献以引用方式并入本文。当涉及螯合剂时,术语“它们的盐及衍生物”是指具有与它们所涉及的螯合剂相同官能结构(例如相同化学主链)以及具有相似或更好螯合特性的盐和衍生物。该术语包括具有酸性部分的螯合剂的碱金属盐、碱土金属盐、铵盐、取代的铵(即单乙醇胺、二乙醇胺、三乙醇铵)盐、酯、以及它们的混合物,尤其是所有的钠盐、钾盐或铵盐。术语“衍生物”还包括“螯合表面活性剂”化合物,诸如美国专利5,284,972中例示的那些,以及包含一个或多个具有与母体螯合剂相同官能结构的螯合基团的大分子诸如美国专利5,747,440中公开的聚合物EDDS(乙二胺二琥珀酸)。
螯合剂可以按所述组合物的总重量计0.001%至10.0%,优选地0.01%至2.0%范围内的量掺入本文的组合物中。
非限制性螯合剂类别包括羧酸、氨基羧酸,其包括氨基酸、磷酸、膦酸、多膦酸、聚乙烯亚胺、多官能取代的芳族化合物、它们的衍生物和盐。
非限制性螯合剂包括下列物质和它们的盐。乙二胺四乙酸(EDTA)、乙二胺三乙酸、乙二胺-N,N'-二琥珀酸(EDDS)、乙二胺-N,N'-二戊二酸(EDDG)、水杨酸、天冬氨酸、谷氨酸、甘氨酸、丙二酸、组氨酸、二亚乙基三胺五乙酸盐(DTPA)、N-羟乙基乙二胺三乙酸盐、次氮基三乙酸盐、乙二胺四丙酸盐、三亚乙基四胺六乙酸盐、乙醇基二甘氨酸、丙二胺四乙酸盐(PDTA)、甲基甘氨酸二乙酸(MODAA)、二亚乙基三胺五乙酸、甲基甘氨酸二乙酸(MGDA)、N-酰基-N,N',N'-乙二胺三乙酸、次氮基三乙酸、乙二胺二戊二酸(EDGA)、2-羟基丙二胺二琥珀酸(HPDS)、甘氨酰胺-N,N'-二琥珀酸(GADS)、2-羟基丙二胺-N-N'-二琥珀酸(HPDDS)、N-2-羟乙基-N,N-二乙酸、甘油亚氨基二乙酸、亚氨基二乙酸-N-2-羟丙基磺酸、天冬氨酸N-羧甲基-N-2-羟丙基-3-磺酸、丙氨酸-N,N'-二乙酸、天冬氨酸-N,N'-二乙酸、天冬氨酸N-一乙酸、亚氨基二琥珀酸、二胺-N,N'-二多元酸、单酰胺-N,N'-二多元酸、二氨基烷基二(磺基琥珀酸)(DDS)、乙二胺-N-N'-双(邻羟基苯基乙酸)、N,N'-双(2-羟基苄基)乙二胺-N,N'-二乙酸、乙二胺四丙酸盐、三亚乙基四胺六乙酸盐、二亚乙基三胺五乙酸盐、吡啶二羧酸、亚乙基二半胱氨酸(EDC)、乙二胺-N,N'-双(2-羟基苯乙酸)(EDDHA)、谷氨酸二乙酸(GLDA)、六腺苷酸氨基羧酸盐(HBED)、聚乙烯亚胺、1-羟基二膦酸盐、氨基三(亚甲基膦酸)(ATMP)、次氮基三亚甲基膦酸盐(NTP)、乙二胺四亚甲基膦酸盐、二亚乙基三胺五亚甲基膦酸盐(DTPMP)、乙烷-1-羟基二膦酸盐(HEDP)、2-膦酰基丁烷-1,2,4-三羧酸、多磷酸、三聚磷酸钠、二磷酸四钠、六偏磷酸、偏磷酸钠、膦酸及其衍生物、氨基亚烷基-聚(亚烷基膦酸)、氨基三(1-乙基膦酸)、乙二胺四(1-乙基膦酸)、氨基三(1-丙基膦酸)、
氨基三(异丙基膦酸)、乙二胺四(亚甲基膦酸)(EDTMP)、1,2-二羟基-3,5-二磺基苯。
4.含水载体
个人护理组合物可为可倾倒液体的形式(环境条件下)。因此,此类组合物将通常包含载体,该载体以按个人护理组合物的重量计约40%至约85%、或者约45%至约80%、或者约50%至约75%的含量存在。载体可包含水,或水和有机溶剂的可混溶混合物,并且在一个方面,可包含水与最小或不显著浓度的有机溶剂,除了另外作为其它必要或任选组分的微量成分附带地掺入组合物中的那些。
可用于本发明的个人护理组合物中的载体可包括水以及低级烷基醇和多元醇的水溶液。可用于本文的低级烷基醇是具有1至6个碳的一元醇,在一个方面,为乙醇和异丙醇。可用于本文的示例性多元醇包括丙二醇、己二醇、甘油和丙烷二醇。
个人护理组合物的pH可约为以下pH:约4.5至约6;约4至约6;约5至约6、约5.5至约6和约4至约5。
G.产品形式
本发明的个人护理组合物可呈现为典型的个人护理制剂形式。它们可为溶液、分散体、乳液、粉剂、滑石、封装体、球体、海绵、固体剂型、泡沫、以及其它递送机制的形式。本发明的组合物可为生发油、免洗型毛发产品诸如处理物、以及定型产品、洗去型毛发产品诸如洗发剂和个人清洁产品、以及处理产品;以及可施用到毛发的任何其它形式。
方法
混浊度方法
此方法用于透明洗发剂中的混浊度。混浊度值越低,洗发剂配制物看起来越澄清。使用GretagMacbeth型号7000或更新的分光光度仪和Xrite,Incorporated供应商提供的软件设定CHIOLL来确定混浊度。将洗发剂离心以去除可能存在的任何气泡。然后将洗发剂放入1cm路径长度单元(MacBeth P/N 27006250或光学中性等同物,其为11/4英寸宽×21/2英寸高×10mm并且由分光光度仪读取,该分光光度仪计算相关混浊度值;以及L*a*b值。通过将洗发剂样品与空气样品比较来定量混浊度。参考用于透明塑料的混浊度和光透射率的ASTM D 1003-00标准测试方法。
本发明的个人护理组合物可具有小于或等于25的混浊度值;小于或等于10的混浊度值;小于或等于9的混浊度值;小于或等于8的混浊度值;小于或等于7的混浊度值和小于或等于3的混浊度值。
粘度测量
可使用具有锥C75-1的锥板式Brookfield RS流变仪在2s-1的恒定剪切速率下在27℃下在3分钟时对于2.5mL样品测量洗发剂粘度。
洗发剂组合物的制备
通过在充分搅拌下添加表面活性剂、去头皮屑剂、香料、粘度调节剂、阳离子聚合物和水的其余部分来制备洗发剂组合物,以确保均匀的混合物。可将混合物加热至50-75℃以加速可溶性试剂的溶解,然后冷却。可根据需要调节产品pH以提供适于施用到人的毛发和头皮上的本发明洗发剂组合物,并且其可基于特定去污表面活性剂和/或其它组分的选择而变化。
结果
图1数据展示了,当洗发剂含有13%的月桂基聚氧乙烯醚-1硫酸钠(SLE1S)表面活性剂和1%的癸基聚氧乙烯醚-1硫酸钠(C10E1)表面活性剂(其中仅阴离子聚合物CarbopolAqua SF(SF1))时,混浊度值随着SF1水平增加而减小,从而导致配制物看起来澄清。在图1中,所评估的阴离子聚合物Carbopol Aqua SF1水平为0.7%、2.0%以及0.7%SF1与0.4%Jaguar Excel阳离子聚合物的组合。
图2-图4展示了,在表面活性剂水平变化的情况下,当阴离子聚合物与阳离子聚合物组合时,在一些基质(chassis)中增加阴离子聚合物Carbopol Aqua SF1不会减小混浊度值,并且在其它基质中,其增加了混浊度值,从而导致配制物类似透明度或不太澄清。
图2展示了13%的月桂基聚氧乙烯醚-1硫酸钠(SLE1S)表面活性剂和1%的癸基聚氧乙烯醚-1硫酸钠(C10E1)与0.7%SF1和0.4%Jaguar Excel的组合;以及13%的月桂基聚氧乙烯醚-1硫酸钠(SLE1S)表面活性剂和1%的癸基聚氧乙烯醚-1硫酸钠(C10E1)与2%SF1和0.4%Jaguar Excel的组合。图2还展示了15%的月桂基聚氧乙烯醚-1硫酸钠(SLE1S)表面活性剂和1%的癸基聚氧乙烯醚-1硫酸钠(C10E1)与0.7%SF1和0.4%Jaguar Excel的组合;以及15%的月桂基聚氧乙烯醚-1硫酸钠(SLE1S)表面活性剂和1%的癸基聚氧乙烯醚-1硫酸钠(C10E1)与2%SF1和0.4%Jaguar Excel的组合。
图3展示了含有13%的月桂基聚氧乙烯醚-1硫酸钠(SLE1S)表面活性剂和1%的癸基聚氧乙烯醚-1硫酸钠(C10E1)与增加水平的SF1和0.4%Jaguar Excel的组合的所有样品,即0.7%SF1与0.4%Jaguar Excel;1%SF1与0.4%Jaguar Excel;1.5%SF1与0.4%Jaguar Excel,并且最后,2%SF1与0.4%Jaguar Excel。
图4展示了13%的月桂基聚氧乙烯醚-1硫酸钠(SLE1S)表面活性剂和1%的癸基聚氧乙烯醚-1硫酸钠(C10E1)与0.7%SF1和0.4%Jaguar Excel的组合;以及11%的月桂基聚氧乙烯醚-1硫酸钠(SLE1S)表面活性剂和1%的癸基聚氧乙烯醚-1硫酸钠(C10E1)与0.7%SF1和0.4%Jaguar Excel的组合;以及11%的月桂基聚氧乙烯醚-1硫酸钠(SLE1S)表面活性剂和1%的癸基聚氧乙烯醚-1硫酸钠(C10E1)与1.5%SF1和0.4%Jaguar Excel的组合;以及11%的月桂基聚氧乙烯醚-1硫酸钠(SLE1S)表面活性剂和1%的癸基聚氧乙烯醚-1硫酸钠(C10E1)与2%SF1和0.4%Jaguar Excel的组合。
非限制性示例
通过常规的配制方法和混和方法可制备以下实施例中举例说明的洗发剂组合物。除非另外指明,否则所有例示量以基于活性物质的重量百分比列出,并且除了微量材料以外,诸如稀释剂、防腐剂、有色溶液、假想成分、植物药物等。除非另外指明,否则所有百分比均基于重量。介绍以下实施例以进一步说明,但不是为了限制本发明:
图5-图8数据展示了在总表面活性剂增加和/或癸基聚氧乙烯醚-1硫酸钠(C10E1)表面活性剂增加时透明度增加(混浊度值减小)的图。
图5展示了11%的月桂基聚氧乙烯醚-1硫酸钠(SLE1S)表面活性剂和1%的癸基聚氧乙烯醚-1硫酸钠(C10E1)与2%SF1和0.4%Jaguar Excel的组合。图5还展示了8%的月桂基聚氧乙烯醚-1硫酸钠(SLE1S)表面活性剂和4%的癸基聚氧乙烯醚-1硫酸钠(C10E1)与2%SF1和0.4%Jaguar Excel的组合。图5还展示了6%的月桂基聚氧乙烯醚-1硫酸钠(SLE1S)表面活性剂和6%的癸基聚氧乙烯醚-1硫酸钠(C10E1)与2%SF1和0.4%JaguarExcel的组合。图5还展示了13%的月桂基聚氧乙烯醚-1硫酸钠(SLE1S)表面活性剂和1%的癸基聚氧乙烯醚-1硫酸钠(C10E1)与2%SF1和0.4%Jaguar Excel的组合。图5还展示了7.5%的月桂基聚氧乙烯醚-1硫酸钠(SLE1S)表面活性剂和7.5%的癸基聚氧乙烯醚-1硫酸钠(C10E1)与2%SF1和0.4%Jaguar Excel的组合。图5还展示了15%的月桂基聚氧乙烯醚-1硫酸钠(SLE1S)表面活性剂和1%的癸基聚氧乙烯醚-1硫酸钠(C10E1)与2%SF1和0.4%Jaguar Excel的组合。最后,图5展示了12%的月桂基聚氧乙烯醚-1硫酸钠(SLE1S)表面活性剂和5%的癸基聚氧乙烯醚-1硫酸钠(C10E1)与2%SF1和0.4%Jaguar Excel的组合。
图6展示了11%的月桂基聚氧乙烯醚-1硫酸钠(SLE1S)表面活性剂和1%的癸基聚氧乙烯醚-1硫酸钠(C10E1)与2%SF1和0.4%Jaguar Excel的组合。图6还展示了13%的月桂基聚氧乙烯醚-1硫酸钠(SLE1S)表面活性剂和1%的癸基聚氧乙烯醚-1硫酸钠(C10E1)与2%SF1和0.4%Jaguar Excel的组合。最后,图6展示了15%的月桂基聚氧乙烯醚-1硫酸钠(SLE1S)表面活性剂和1%的癸基聚氧乙烯醚-1硫酸钠(C10E1)与2%SF1和0.4%JaguarExcel的组合。
图7展示了13%的月桂基聚氧乙烯醚-1硫酸钠(SLE1S)表面活性剂和1%的癸基聚氧乙烯醚-1硫酸钠(C10E1)与0.7%SF1和0.4%Jaguar Excel的组合。图7展示了14%的月桂基聚氧乙烯醚-1硫酸钠(SLE1S)表面活性剂和1%的癸基聚氧乙烯醚-1硫酸钠(C10E1)与0.7%SF1和0.4%Jaguar Excel的组合。图7最后展示了15%的月桂基聚氧乙烯醚-1硫酸钠(SLE1S)表面活性剂和1%的癸基聚氧乙烯醚-1硫酸钠(C10E1)与0.7%SF1和0.4%JaguarExcel的组合。
图8展示了6%的月桂基聚氧乙烯醚-1硫酸钠(SLE1S)表面活性剂和6%的癸基聚氧乙烯醚-1硫酸钠(C10E1)与2%SF1和0.4%Jaguar Excel的组合。图8展示了8%的月桂基聚氧乙烯醚-1硫酸钠(SLE1S)表面活性剂和4%的癸基聚氧乙烯醚-1硫酸钠(C10E1)与2%SF1和0.4%Jaguar Excel的组合。最后,图8展示了11%的月桂基聚氧乙烯醚-1硫酸钠(SLE1S)表面活性剂和1%的癸基聚氧乙烯醚-1硫酸钠(C10E1)与2%SF1和0.4%JaguarExcel的组合。
图9数据展示了当pH减小时配制物混浊度值减小并且看起来更澄清。
图9展示了13%的月桂基聚氧乙烯醚-1硫酸钠(SLE1S)表面活性剂和1%的癸基聚氧乙烯醚-1硫酸钠(C10E1)与0.7%SF1和0.4%Jaguar Excel在pH 5.5下的组合。最后,图9展示了13%的月桂基聚氧乙烯醚-1硫酸钠(SLE1S)表面活性剂和1%的癸基聚氧乙烯醚-1硫酸钠(C10E1)与0.7%SF1和0.4%Jaguar Excel在pH 4.5下的组合。
图10数据展示了改变阳离子聚合物类型可能影响透明度。数据展示了阳离子聚合物LR400、LR30M、JR 30M、JR400和Excel均导致改善的透明度。
图10展示了0.4%Jaguar Excel分子量(MW)=1,200,000g/mol,电荷密度(CD)=0.7meq/g);0.4%N-Hance BF17(MW=800,000g/mol,CD=1.7meq/g),0.4N-Hance 3196(MW=1,700,000g/mol,CD=0.7meq/g);0.4%LR400(MW=400,000g/mol,CD=0.7meq/g);0.4%JR400(MW=400,000g/mol,CD=1.25meq/g);0.4%JR30M(MW=2,000,000g/mol,CD=1.25meq/g);0.4%LR30M(MW=1,800,000g/mol,CD=0.7meq/g),并且最后,0.4KG30M(MW1,800,000g/mol,CD=1.9meq/g);每个阳离子聚合物类型与13%的月桂基聚氧乙烯醚-1硫酸钠(SLE1S)表面活性剂和1%的癸基聚氧乙烯醚-1硫酸钠(C10E1)及0.7%SF1组合。
图11数据展示了在添加香料之前将配制物的pH调节到约5.5-5.6的pH改善配制物的混浊度值。
图11展示了13%的月桂基聚氧乙烯醚-1硫酸钠(SLE1S)表面活性剂和1%的癸基聚氧乙烯醚-1硫酸钠(C10E1)与0.7%SF1和0.4%Jaguar Excel的组合,其中在添加香料之前将pH调节到5.5-5.6。图11展示了11%的月桂基聚氧乙烯醚-1硫酸钠(SLE1S)表面活性剂和1%的癸基聚氧乙烯醚-1硫酸钠(C10E1)与0.7%SF1和0.4%Jaguar Excel的组合,其中在添加香料之后将pH调节到5.5-5.6。图11展示了11%的月桂基聚氧乙烯醚-1硫酸钠(SLE1S)表面活性剂和1%的癸基聚氧乙烯醚-1硫酸钠(C10E1)与0.7%SF1和0.4%JaguarExcel的组合,其中在添加香料之前将pH调节到5.5-5.6。最后,图11展示了11%的月桂基聚氧乙烯醚-1硫酸钠(SLE1S)表面活性剂和1%的癸基聚氧乙烯醚-1硫酸钠(C10E1)与0.7%SF1和0.4%Jaguar Excel的组合,其中在添加香料之前将pH调节到5.5-5.6。
图12数据展示了所有含有C10E1的配制物相对于所有含有SLE1S的配制物更澄清,混浊度值更低。图12数据还显示了,当C10E1水平增加时,混浊度值减小,这意味着具有更多C10E1的洗发剂的外观更澄清。
图12展示了12%的月桂基聚氧乙烯醚-1硫酸钠(SLE1S)表面活性剂与0.7%SF1和0.4%Jaguar Excel的组合。图12展示了12%的癸基聚氧乙烯醚-1硫酸钠(C10E1)与2%SF1和0.4%Jaguar Excel的组合。最后,图12展示了15%的癸基聚氧乙烯醚-1硫酸钠(C10E1)与2.5%SF1和0.4%Jaguar Excel的组合。
介绍以下实施例以进一步说明,但不是为了限制本发明:
本文所公开的量纲和值不应理解为严格限于所引用的精确数值。相反,除非另外指明,否则每个此类量纲旨在表示所述值以及围绕该值功能上等同的范围。例如,公开为“40mm”的量纲旨在表示“约40mm”。
除非明确排除或以其它方式限制,本文中引用的每一篇文献,包括任何交叉引用或相关专利或专利申请以及本申请对其要求优先权或其有益效果的任何专利申请或专利,均据此全文以引用方式并入本文。对任何文献的引用不是对其作为与本发明的任何所公开或本文受权利要求书保护的现有技术的认可,或不是对其自身或与任何一个或多个参考文献的组合提出、建议或公开任何此类发明的认可。此外,当本发明中术语的任何含义或定义与以引用方式并入的文献中相同术语的任何含义或定义矛盾时,应当服从在本发明中赋予该术语的含义或定义。
虽然已举例说明和描述了本发明的具体实施方案,但是对于本领域技术人员来说显而易见的是,在不脱离本发明的实质和范围的情况下可作出各种其他变化和修改。因此,本文旨在于所附权利要求中涵盖属于本发明范围内的所有此类变化和修改。
Claims (15)
1.一种个人护理组合物,所述个人护理组合物包含:
a)12%至25%,优选地12%至20%,优选地12%至18%,优选地12%至14%的一种或多种表面活性剂;
b)0.01%至10%,优选地0.1%至9%,优选地0.5%至3%的一种或多种可溶性头皮健康活性物质;
c)0.1%至4%,优选地0.5%至2%,优选地0.7%至1%的增稠聚合物,其中所述增稠聚合物选自基于丙烯酸、甲基丙烯酸或其它相关衍生物的均聚物、碱溶胀性和疏水改性的碱溶胀性丙烯酸类共聚物或甲基丙烯酸酯共聚物、可溶性交联丙烯酸类聚合物、缔合聚合物增稠剂以及它们的混合物,优选地其中所述一种或多种增稠聚合物选自聚丙烯酸酯、聚甲基丙烯酸酯、聚乙基丙烯酸酯和聚丙烯酰胺、丙烯酸/丙烯腈共聚物、丙烯酸酯/硬脂基聚氧乙烯醚-20衣康酸酯共聚物、丙烯酸酯/鲸蜡基聚氧乙烯醚-20衣康酸酯共聚物、丙烯酸酯/氨基丙烯酸酯/C10-30烷基PEG-20衣康酸酯共聚物、丙烯酸酯/氨基丙烯酸酯共聚物、丙烯酸酯/硬脂基聚氧乙烯醚-20甲基丙烯酸酯共聚物、丙烯酸酯/山嵛基聚氧乙烯醚-25甲基丙烯酸酯共聚物、丙烯酸酯/硬脂基聚氧乙烯醚-20甲基丙烯酸酯交联聚合物、丙烯酸酯/山嵛基聚氧乙烯醚-25甲基丙烯酸酯/HEMA交联聚合物、丙烯酸酯/新癸酸乙烯酯交联聚合物、丙烯酸酯/异癸酸乙烯酯交联聚合物、丙烯酸酯/棕榈油醇聚醚-25丙烯酸酯共聚物、丙烯酸/丙烯酰胺基甲基丙烷磺酸共聚物、以及丙烯酸酯/丙烯酸C10-C30烷基酯交联聚合物、卡波姆、疏水改性的聚丙烯酸酯;疏水改性的聚丙烯酸、疏水改性的聚丙烯酰胺;疏水改性的聚醚,其中这些材料可具有可选自鲸蜡基、硬脂基、油酰基、以及它们的组合的疏水物,丙烯酰胺/丙烯酸铵共聚物(和)聚异丁烯(和)聚山梨酸酯20;丙烯酰胺/丙烯酰二甲基牛磺酸钠共聚物/异十六烷/聚山梨酸酯80、丙烯酰二甲基牛磺酸铵/VP共聚物、丙烯酸钠/丙烯酰二甲基牛磺酸钠共聚物、丙烯酸酯共聚物、丙烯酸酯交联聚合物-4、丙烯酸酯交联聚合物-3、丙烯酸酯/山嵛基聚氧乙烯醚-25甲基丙烯酸酯共聚物、丙烯酸酯/丙烯酸C10-C30烷基酯交联聚合物、丙烯酸酯/硬脂基聚氧乙烯醚-20衣康酸酯共聚物、聚丙烯酸铵/异十六烷/PEG-40蓖麻油;卡波姆钠、交联的聚乙烯吡咯烷酮(PVP)、聚丙烯酰胺/C13-14异链烷烃/月桂基聚氧乙烯醚-7、聚丙烯酸酯13/聚异丁烯/聚山梨酸酯20、聚丙烯酸酯交联聚合物-6、聚酰胺-3、聚季铵盐-37(和)氢化聚癸烯(和)十三烷基聚氧乙烯醚-6、丙烯酰胺/丙烯酰基二甲基牛磺酸钠/丙烯酸共聚物、丙烯酸钠/丙烯酰基二甲基牛磺酸盐/二甲基丙烯酰胺、交联聚合物(和)异十六烷(和)聚山梨酸酯60、聚丙烯酸钠;
d)0.01%至0.8%的阳离子聚合物,优选地0.05至0.8%,优选地0.1%至0.4%的阳离子聚合物;
其中所述个人护理组合物具有4.5至6的pH,并且其中所述个人护理组合物具有小于或等于25的混浊度值。
2.根据前述权利要求中任一项所述的个人护理组合物,其中所述表面活性剂为选自下列的阴离子表面活性剂:具有直链或支链烷基链的阴离子烷基硫酸盐和烷基醚硫酸盐以及它们的混合物,优选地其中所述表面活性剂为选自下列的阴离子表面活性剂:
a)R1O(CH2CHR3O)ySO3M;
b)CH3(CH2)zCHR2CH2O(CH2CHR3O)ySO3M;以及
c)它们的混合物,
其中R1表示CH3(CH2)10,R2表示H或烃基团,所述烃基团包含1至4个碳原子,使得z和R2中碳原子的总和为8,R3为H或CH3,y为0至7,当y不为零(0)时,y的平均值为1,并且M为一价或二价带正电荷的阳离子。
3.根据前述权利要求中任一项所述的个人护理组合物,其中所述表面活性剂为选自下列的表面活性剂或者表面活性剂的组合:月桂基硫酸钠;月桂基聚氧乙烯醚-n硫酸钠,其中n介于0.5至3.5之间;C10-15烷基硫酸钠,其中烷基链可为直链或支链的;C10-15烷基聚氧乙烯醚-n硫酸钠,其中n介于0.5至3.5之间,并且烷基链可为直链或支链的;癸基硫酸钠;癸基聚氧乙烯醚-n硫酸钠,其中n介于0.5至3.5之间;十一烷基硫酸钠;十一烷基聚氧乙烯醚-n硫酸钠,其中n介于0.5至3.5之间;十三烷基硫酸钠;十三烷基聚氧乙烯醚-n硫酸钠,其中n介于0.5至3.5之间;阴离子表面活性剂,所述阴离子表面活性剂选自:
a)R1O(CH2CHR3O)ySO3M;
b)CH3(CH2)zCHR2CH2O(CH2CHR3O)ySO3M;以及
c)它们的混合物,
其中R1表示CH3(CH2)10,R2表示H或烃基团,所述烃基团包含1至4个碳原子,使得z和R2中碳原子的总和为8,R3为H或CH3,y为0至7,当y不为零(0)时,y的平均值为1,并且M为一价或二价带正电荷的阳离子。
4.根据前述权利要求中任一项所述的个人护理组合物,其中所述表面活性剂为选自下列的不含硫酸盐的表面活性剂中的一种或多种:羟乙基磺酸盐的钠盐、铵盐或钾盐;磺酸盐的钠盐、铵盐或钾盐;醚磺酸盐的钠盐、铵盐或钾盐;磺基琥珀酸盐的钠盐、铵盐或钾盐;磺基乙酸盐的钠盐、铵盐或钾盐;甘氨酸盐的钠盐、铵盐或钾盐;肌氨酸盐的钠盐、铵盐或钾盐;谷氨酸盐的钠盐、铵盐或钾盐;丙氨酸盐的钠盐、铵盐或钾盐;羧酸盐的钠盐、铵盐或钾盐;牛磺酸盐的钠盐、铵盐或钾盐;磷酸酯的钠盐、铵盐或钾盐;以及它们的组合。
5.根据前述权利要求中任一项所述的个人护理组合物,所述个人护理组合物还包含0.25%至15%的一种或多种两性辅助表面活性剂、非离子辅助表面活性剂或两性离子辅助表面活性剂。
6.根据前述权利要求中任一项所述的个人护理组合物,其中所述可溶性头皮健康活性物质为羟基吡啶,优选地其中所述羟基吡啶酮为吡罗克酮乙醇胺。
7.根据前述权利要求中任一项所述的个人护理组合物,其中所述可溶性头皮健康活性物质为唑,优选地其中所述唑为氯咪巴唑。
8.根据前述权利要求中任一项所述的个人护理组合物,其中所述可溶性头皮健康活性物质为嗜球果伞素,优选地其中所述嗜球果伞素为嘧菌酯。
9.根据前述权利要求中任一项所述的个人护理组合物,其中所述组合物的pH为5至6,优选地4至5。
10.根据前述权利要求中任一项所述的个人护理组合物,其中所述个人护理组合物具有小于或等于10的混浊度值,优选地具有小于或等于9的混浊度值,优选地具有小于或等于8的混浊度值,优选地具有小于或等于7的混浊度值,优选地具有小于或等于3的混浊度值。
11.根据前述权利要求中任一项所述的个人护理组合物,还包含0.25%至15%的一种或多种两性辅助表面活性剂、非离子辅助表面活性剂或两性离子辅助表面活性剂。
12.根据前述权利要求中任一项所述的个人护理组合物,其中所述组合物还包含调理剂,优选地其中所述调理剂为有机硅。
13.根据前述权利要求中任一项所述的个人护理组合物,其中所述有机硅具有小于100nm的粒度。
14.根据前述权利要求中任一项所述的个人护理组合物,所述个人护理组合物还包含一种或多种头皮健康剂,所述一种或多种头皮健康剂选自水杨酸、薄荷醇和/或乳酸薄荷酯以及它们的混合物。
15.根据前述权利要求中任一项所述的个人护理组合物,所述个人护理组合物还包含0.5%至7%的香料。
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EP4048407A1 (en) | 2019-10-24 | 2022-08-31 | The Procter & Gamble Company | Personal care composition preservatives level optimization |
WO2021081557A1 (en) | 2019-10-24 | 2021-04-29 | The Procter & Gamble Company | Personal care composition preservatives level optimization |
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2020
- 2020-12-18 JP JP2022532709A patent/JP7405982B2/ja active Active
- 2020-12-18 CA CA3159415A patent/CA3159415A1/en active Pending
- 2020-12-18 CN CN202080084929.0A patent/CN114845694B/zh active Active
- 2020-12-18 EP EP20842776.5A patent/EP4076375A1/en active Pending
- 2020-12-18 US US17/126,369 patent/US11865198B2/en active Active
- 2020-12-18 BR BR112022011708A patent/BR112022011708A2/pt unknown
- 2020-12-18 MX MX2022005758A patent/MX2022005758A/es unknown
- 2020-12-18 WO PCT/US2020/065817 patent/WO2021127318A1/en unknown
Patent Citations (3)
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US20070202069A1 (en) * | 2006-02-24 | 2007-08-30 | Krishnan Tamareselvy | Polymers Containing Silicone Copolyol Macromers and Personal Care Compositions Containing Same |
US20170333320A1 (en) * | 2014-11-18 | 2017-11-23 | Conopco, Inc., D/B/A Unilever | Composition comprising salt of acyl glutamate as primary surfactant or primary anionic surfactant |
US20180311135A1 (en) * | 2017-04-26 | 2018-11-01 | The Procter & Gamble Company | Compositions with anionic and cationic polymers having improved benefits |
Also Published As
Publication number | Publication date |
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EP4076375A1 (en) | 2022-10-26 |
JP7405982B2 (ja) | 2023-12-26 |
BR112022011708A2 (pt) | 2022-09-06 |
WO2021127318A1 (en) | 2021-06-24 |
US20210186839A1 (en) | 2021-06-24 |
JP2023504170A (ja) | 2023-02-01 |
CN114845694B (zh) | 2024-04-16 |
CA3159415A1 (en) | 2021-06-24 |
US11865198B2 (en) | 2024-01-09 |
MX2022005758A (es) | 2022-06-09 |
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