CN115444005B - Mugwort mosquito repellent and preparation method thereof - Google Patents
Mugwort mosquito repellent and preparation method thereof Download PDFInfo
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- CN115444005B CN115444005B CN202211060279.3A CN202211060279A CN115444005B CN 115444005 B CN115444005 B CN 115444005B CN 202211060279 A CN202211060279 A CN 202211060279A CN 115444005 B CN115444005 B CN 115444005B
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- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
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Abstract
The invention provides mugwort mosquito repellent and a preparation method thereof, and relates to the field of mosquito repellent products, wherein the mugwort mosquito repellent comprises the following raw materials: mugwort, peppermint, honeysuckle, star anise, biota orientalis, ilex pedunculata, tarragon, eucommia ulmoides, achyranthes bidentata, litsea cubeba, mountain suffruticosa and madder. According to the invention, the wormwood is used as a main component, the components such as alcohol, the deet, the Pai-karitin and the eucalyptus citriodora are not added, the synergistic effect of the plant components is effectively exerted by utilizing the compounding of the wormwood with other plant components, and the prepared mosquito repellent has good mosquito repellent effect, better effective protection time and effective protection rate and smaller irritation.
Description
Technical Field
The invention relates to the field of mosquito repellent supplies, in particular to wormwood mosquito repellent water and a preparation method thereof.
Background
The products with the mosquito-repellent effect commonly used at present comprise floral water, mosquito-repellent incense sheets, mosquito-repellent cream, mosquito-repellent water and the like, wherein after the mosquito-repellent water is smeared, the invasion of viruses after mosquito bites can be prevented, and meanwhile, the discomfort after the mosquito bites can be relieved rapidly, so that the mosquito-repellent water is widely used. However, most of the existing mosquito repellent adopts single preparation, some products have sticky feeling or contain chemical components, the irritation is large, and the mosquito repellent containing natural plants is often short in mosquito repellent time effect and poor in mosquito repellent effect. In addition, since the mosquito repellent water generally contains alcohol components or mosquito repellent glue, and reacts with benzophenone components in the sunscreen cream to cause allergic phenomena, the mixing of the mosquito repellent water with the sunscreen cream is limited, and inconvenience is caused. For example, patent CN103494749B discloses a natural mosquito repellent, which comprises the following components in parts by weight: 50-70 parts of mugwort leaf, 30-40 parts of star anise, 10-20 parts of mint, 10-20 parts of lavender and 10-20 parts of dark plum; the mosquito repellent water prepared by the formula has natural sources, is safe and nontoxic, has good mosquito repellent effect and low cost, but contains alcohol components.
For such problems, literature: zhu Yike preparation and Zhang Yongliang preparation and application of compound mugwort mosquito repellent liquid [ J ]]Journal of Chinese medicine clinical, 2016,28 (12): 4. Through orthogonal test design, supercritical CO 2 Extraction and mosquito biting experiments, a supercritical CO prepared from 6 Chinese herbal medicines including wormwood, rhizoma atractylodis, ligusticum wallichii, magnolia officinalis, calamus and camphor is developed 2 The extract is a compound Chinese herbal medicine mosquito repellent liquid which is prepared by proper proportion, not only has the effect of repelling mosquitoes, but also effectively solves the defect that commercial mosquito repellent products mainly prepared from chemical synthetic medicines are harmful to human bodies after smelling.
Also as in patent CN109329319B, a preparation method of a traditional Chinese medicine fermented mosquito repellent liquid, a stock solution and a diluent thereof are disclosed, and the preparation method of the traditional Chinese medicine fermented mosquito repellent liquid comprises the steps of fermenting and culturing the traditional Chinese medicine raw materials and a culture medium, wherein the fermenting and culturing comprises lactobacillus fermentation and bacillus fermentation, so as to obtain the traditional Chinese medicine fermented mosquito repellent liquid. The raw materials of the product are simple and easy to obtain, the components are natural, the environment is protected, and the product has no stimulation to human bodies; the production process of the biological fermentation technology is simple and convenient, the reaction condition is mild, and the active ingredients in the mosquito-repellent traditional Chinese medicine raw materials can be fully extracted and reserved; the metabolite of the zymophyte can also be synergistic with active ingredients in the raw medicinal materials of the mosquito-repellent traditional Chinese medicine, so that the mosquito-repellent and insect-repellent effect, antipruritic and detumescence effects of the traditional Chinese medicine fermented mosquito-repellent liquid are remarkable. However, the preparation method of the invention involves a fermentation process, is time-consuming as a whole and has high requirements for strains.
Aiming at the problems that the mosquito repellent in the prior art has heavy sticky feeling, contains chemical components and further causes irritation and cannot be mixed with sun cream, the mosquito repellent with comfortable skin feeling, natural components and small irritation is necessary to find.
Disclosure of Invention
Aiming at the problems existing in the prior art, the invention provides the wormwood mosquito repellent water and the preparation method thereof.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:
the invention provides mugwort mosquito repellent water, which comprises the following raw materials: mugwort, peppermint, honeysuckle, star anise, biota orientalis, ilex pedunculata, tarragon, eucommia ulmoides, achyranthes bidentata, litsea cubeba, mountain suffruticosa and madder.
Further, the wormwood mosquito repellent comprises the following components in parts by weight: 28-40 parts of wormwood, 15-25 parts of mint, 15-25 parts of honeysuckle, 15-20 parts of star anise, 10-18 parts of cacumen biotae, 10-18 parts of ilex chinensis leaves, 10-18 parts of artemisia capillaris, 8-15 parts of eucommia ulmoides, 5-12 parts of achyranthes bidentata, 8-12 parts of litsea cubeba, 5-10 parts of mountain suffruticosa and 5-8 parts of madder.
Preferably, the wormwood mosquito repellent comprises the following components in parts by weight: 30-35 parts of wormwood, 15-22 parts of mint, 15-22 parts of honeysuckle, 18-20 parts of star anise, 12-18 parts of cacumen biotae, 12-18 parts of ilex chinensis leaves, 12-18 parts of artemisia capillaris, 8-12 parts of eucommia ulmoides, 6-10 parts of achyranthes bidentata, 10-12 parts of litsea cubeba, 5-8 parts of Securinega suffruticosa and 6-8 parts of madder.
Further preferably, the wormwood mosquito repellent water comprises the following components in parts by weight: 30 parts of wormwood, 18 parts of mint, 18 parts of honeysuckle, 18 parts of star anise, 15 parts of biota orientalis, 15 parts of ilex latifolia leaf, 15 parts of tarragon, 10 parts of eucommia bark, 8 parts of achyranthes root, 11 parts of litsea cubeba, 6 parts of mountain Securinega and 7 parts of madder.
Further, the weight ratio of the mugwort to the holly leaves to the litsea cubeba is 28-40:10-18:8-12.
Preferably, the weight ratio of the mugwort to the holly leaves to the litsea cubeba is 30:15:11.
Further, the weight ratio of the mugwort to the madder is 28-40:6-8.
Preferably, the weight ratio of the mugwort to the madder is 30:7.
Further, the invention also provides a preparation method of the wormwood mosquito repellent water, which comprises the following steps:
(1) Mixing folium Artemisiae Argyi, herba Menthae, flos Lonicerae, fructus Anisi Stellati, folium Platycladi, folium Ilicis Pubescentis, herba Artemisiae Scopariae and fructus Litseae, soaking in water, heating to boil, and filtering to obtain filtrate A and residue;
(2) Mixing the rest folium Artemisiae Argyi, herba Artemisiae Scopariae, eucommiae cortex, achyranthis radix, folium Securinegae Suffruticosae and radix Rubiae, soaking in water, boiling, and filtering to obtain filtrate B and residue;
(3) Mixing filtrate A and filtrate B, and sterilizing.
Further, the weight ratio of the moxa in the step (1) to the moxa in the step (2) is 3-6:1-2.
Further, the soaking time in the steps (1) and (2) is 30-60min.
Further, the water in the step (1) is added in an amount which is 15-18 times of the total weight of the mugwort, the peppermint, the honeysuckle, the star anise, the biota orientalis, the ilex latifolia leaf, the artemisia capillaris and the litsea cubeba; the water in the step (2) is added in an amount which is 12-15 times that of the rest of wormwood, tarragon, eucommia bark, achyranthes root, suffruticosa and madder.
In the invention, the wormwood is used as the whole herb, and has the effects of warming channels, removing dampness, dispelling cold, stopping bleeding, diminishing inflammation, relieving asthma, relieving cough, preventing miscarriage, resisting allergy and the like.
The mint and tender stem tip can be used as vegetable food, and the whole herb can be used as medicine for treating common cold, fever and sore throat, headache, conjunctival congestion and pain, muscle pain, skin rubella and pruritus, measles and the like, and is also effective on carbuncles, scabies, tinea and sores, contains menthol, and has the effects of preserving and sterilizing, promoting urination, reducing phlegm, invigorating stomach, promoting digestion and the like.
Honeysuckle flower, also called honeysuckle, is sweet in taste, cold in nature and nontoxic. Powder without toxicity, powder with toxicity, death, life and transformation of bad ones.
Fructus Anisi Stellati, fruit, especially cold hernia and abdominal pain, cold pain of waist and knee, vomiting due to stomach cold, pain in stomach and abdomen, cold-damp beriberi, etc. Has obvious effects on treating intestinal qi depression, hernia deflection, waist heavy thorn and distention, waist diseases such as thorn, constipation, abdominal distention such as tympanites, shortness of breath, wind toxin and dampness, attack to form sores, skin and meat with purple pus breaking, walking weakness, skin and meat dryness-heat and the like.
The biota orientalis leaves are crisp in texture and easy to break. One of the blood-cooling hemostatic herbs with slightly fragrant smell and bitter taste has the effects of stopping bleeding, blackening beard and hair and relieving cough and asthma.
The folium Ilicis Purpureae is leaf of ilex Purpureae of ilex, and can be used for treating scald, chronic ulcer, obliteration angiitis, acute and chronic bronchitis, pneumonia, urinary tract infection, bacillary dysentery, traumatic hemorrhage, frozen chilblain, and rhagadia.
Herba Artemisiae Scopariae is young stem and leaf of herba Artemisiae Scopariae of Compositae, and has effects of promoting bile flow, relieving fever, and resisting microorganism.
Eucommia ulmoides is bark of eucommia ulmoides belonging to eucommia ulmoides family, and has effects of nourishing liver and kidney, strengthening tendons and bones, preventing miscarriage, treating soreness and pain of waist and knees, dribbling urine, yin-dampness itching, miscarriage, fetal movement, and hypertension.
Achyranthes root is the dry root of achyranthes bidentata of amaranthaceae, has the functions of nourishing liver and kidney, strengthening tendons and bones, removing blood stasis, dredging channels, and guiding blood downwards. Can be used for treating soreness of waist and knees, weakness of tendons and bones, amenorrhea, dizziness due to liver-yang.
Litsea cubeba has the effects of dispelling wind and cold, regulating qi and relieving pain. Can be used for treating vomiting due to stomach cold, abdominal pain due to stomach cold, cold hernia, abdominal pain, cold-dampness stagnation, turbid urine. It can be used for treating carbuncle, furuncle, swelling and pain, mastitis, insect bite, snake bite, and mosquito bite.
Mountain suffruticosa, has the following effects: clearing away heat and toxic material, dispelling wind and dredging collaterals, and expelling parasites. Can be used for treating common cold, toothache, dysentery, rheumatic arthralgia, ascariasis; it is used for treating incised wound, traumatic injury and cervical lymph node tuberculosis.
Madder, radix Rubiae, which has the property of cold entering blood system, can cool blood and stop bleeding and remove blood stasis, climbs herb for many years.
The invention has the technical effects that:
the invention takes the wormwood as the main raw material, and the wormwood mosquito repellent principle is mainly due to the effect of 1, 8-cineole, so that the corresponding effect is difficult to achieve at low concentration, and meanwhile, compared with the mosquito repellent amine, the Pai-karidine, the eucalyptus citriodora oil and the like, the wormwood mosquito repellent effect is relatively poor. Aiming at the problems, the invention uses the wormwood as a main component, utilizes the combination of the wormwood and other plant components to effectively exert the synergistic effect among the plant components, wherein the synergistic effect of the wormwood and the madder in a body system is particularly obvious, the finally prepared mosquito repellent has good mosquito repellent effect, the effective protection time and the effective protection rate are both better, the mosquito repellent does not contain alcohol and components with larger irritation, is harmless to human bodies, and can not generate sensitization risk when being used together with sun cream.
Detailed Description
Other advantages and effects of the present invention will become apparent to those skilled in the art from the following disclosure, which describes the embodiments of the present invention with reference to specific examples. The invention may be practiced or carried out in other embodiments that depart from the specific details, and the details of the present description may be modified or varied from the spirit and scope of the present invention.
Before the embodiments of the invention are explained in further detail, it is to be understood that the invention is not limited in its scope to the particular embodiments described below; it is also to be understood that the terminology used in the examples of the invention is for the purpose of describing particular embodiments only, and is not intended to limit the scope of the invention.
Where numerical ranges are provided in the examples, it is understood that unless otherwise stated herein, both endpoints of each numerical range and any number between the two endpoints are significant both in the numerical range. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
It should be noted that the raw materials used in the present invention are all common commercial products, and therefore the sources thereof are not particularly limited. Formulation and preparation method of each example (raw material replacement is needed when the mosquito repellent in comparative example 5 is prepared):
the wormwood mosquito repellent water comprises the following raw materials: mugwort, peppermint, honeysuckle, star anise, biota orientalis, ilex pedunculata, tarragon, eucommia ulmoides, achyranthes bidentata, litsea cubeba, mountain suffruticosa and madder.
The preparation method of the wormwood mosquito repellent water comprises the following steps:
(1) Mixing folium Artemisiae Argyi, herba Menthae, flos Lonicerae, fructus Anisi Stellati, folium Platycladi, folium Ilicis Purpureae, herba Artemisiae Scopariae and fructus Litseae, soaking in water (the water content is 16 times of total weight of folium Artemisiae Argyi, herba Menthae, flos Lonicerae, fructus Anisi Stellati, folium Platycladi, folium Ilicis Purpureae, herba Artemisiae Scopariae and fructus Litseae) for 50min, boiling, filtering to obtain filtrate A and residue;
(2) Mixing the rest folium Artemisiae Argyi with herba Artemisiae Scopariae, eucommiae cortex, achyranthis radix, rhizoma Securinegae Suffruticosae and radix Rubiae, soaking in water (the water content is 12 times of the rest folium Artemisiae Argyi, herba Artemisiae Scopariae, eucommiae cortex, achyranthis radix, rhizoma Securinegae Suffruticosae and radix Rubiae) for 50min, boiling, and filtering to obtain filtrate B and residue.
Wherein the weight ratio of the mugwort in the step (1) to the mugwort in the step (2) is 4:1.
The specific formula of the wormwood mosquito repellent water is shown in the following table:
table 1 examples 1-3 wormwood mosquito repellent water formulation
| Raw materials (portion) | Example 1 | Example 2 | Example 3 |
| Mugwort leaf | 28 | 40 | 30 |
| Mint | 15 | 25 | 18 |
| Honeysuckle | 15 | 25 | 18 |
| Anise fennel | 15 | 20 | 18 |
| Platycladus orientalis leaf | 10 | 18 | 15 |
| Folium Ilicis Pubescentis | 10 | 18 | 15 |
| Herba Artemisiae Scopariae | 10 | 18 | 15 |
| Eucommia ulmoides | 8 | 15 | 10 |
| Achyranthes root | 5 | 12 | 8 |
| Litsea cubeba | 8 | 12 | 11 |
| Mountain suffruticosa (Fr.) kurz | 5 | 10 | 6 |
| Rubiae radix | 5 | 8 | 7 |
Table 2 comparative examples 1-5 mugwort mosquito repellent formulations
The mugwort mosquito repellent effect test of the invention
Test 1: test of attack force
110 Aedes albopictus and test mice are placed in the closed space, the number of mosquitoes stopped within 10min is recorded, more than 5 mosquitoes are considered to be qualified for the mosquitoes and the mice, a next repellent test can be carried out, and 300 aedes albopictus qualified for the attack force can be obtained after multiple screening.
Test 2: equal amounts of mosquito repellent in each example of the present invention were applied to the exposed abdomen (2 cm. Times.2 cm) of each group of mice, respectively, in an amount of 1.5. Mu.L/cm 2 And shielding other parts, wherein 10 mice in each group are selected as a blank control group, only an equal amount of distilled water is coated, each group of mice is marked by a marker pen, each group of mice and 300 Aedes albopictus are placed in a closed space for 5min after the mice are coated for 1h, the whole-course video recording is carried out by using an imaging device, whether mosquitoes stop on exposed skin is observed, the test is carried out once per hour, if 1 mosquito stops sucking blood, the test is judged to be the end of the test for measuring the effective protection time, the effective protection time is counted, the further test is carried out, the number of the mosquitoes stopped within 5min is counted after the test is completed for 15 hours, and the effective protection rate is calculated.
Effective protection rate = (number of mosquito-off in control group-number of mosquito-off in water-repellent-coated group)/number of mosquito-off in control group×100%
The above test was performed in combination with a mouse test by the method described in GB/T13917.9-2009, and the results are shown in Table 3:
TABLE 3 results of the avoidance test
| Examples | Effective guard time (h) | Effective protection rate (%) |
| Blank control group | 1.0 | - |
| Example 1 | 14.1 | 84.78 |
| Example 2 | 15.6 | 86.96 |
| Example 3 | 16.1 | 90.22 |
| Comparative example 1 | 13.1 | 63.04 |
| Comparative example 2 | 12.7 | 51.09 |
| Comparative example 3 | 10.6 | 40.22 |
| Comparative example 4 | 9.0 | 15.22 |
| Comparative example 5 | 12.1 | 30.43 |
According to the research results, the effective protection time of the mosquito repellent water can reach more than 14.1h, and the effective protection rate of 15h can reach more than 84.78%. From comparison of the results of comparative examples 1-2 and example 1, it can be deduced that the synergistic effect between mugwort and madder in mosquito repellent aquatic products is relatively important, and the effective protection time and the effective protection rate are both significantly affected. The experimental result in comparative example 5 reflects the key effect of specific raw materials, and when part of raw materials are replaced by lavender or dahurian angelica root, even though the relevant raw materials have a certain mosquito repellent effect, obvious advantages cannot be exerted in the product of the invention. Meanwhile, compared with some commercial products, the mosquito repellent water has outstanding effects.
Finally, it should be noted that the above description is only for illustrating the technical solution of the present invention, and not for limiting the scope of the present invention, and that the simple modification and equivalent substitution of the technical solution of the present invention can be made by those skilled in the art without departing from the spirit and scope of the technical solution of the present invention.
Claims (6)
1. The wormwood mosquito repellent water is characterized in that: the weight portion of the composition comprises: 28-40 parts of wormwood, 15-25 parts of mint, 15-25 parts of honeysuckle, 15-20 parts of star anise, 10-18 parts of cacumen biotae, 10-18 parts of ilex chinensis leaves, 10-18 parts of artemisia capillaris, 8-15 parts of eucommia ulmoides, 5-12 parts of achyranthes bidentata, 8-12 parts of litsea cubeba, 5-10 parts of mountain suffruticosa and 5-8 parts of madder;
the preparation method of the wormwood mosquito repellent water comprises the following steps:
(1) Mixing folium Artemisiae Argyi, herba Menthae, flos Lonicerae, fructus Anisi Stellati, folium Platycladi, folium Ilicis Pubescentis, herba Artemisiae Scopariae and fructus Litseae, soaking in water, heating to boil, and filtering to obtain filtrate A and residue;
(2) Mixing the rest folium Artemisiae Argyi, herba Artemisiae Scopariae, eucommiae cortex, achyranthis radix, folium Securinegae Suffruticosae and radix Rubiae, soaking in water, boiling, and filtering to obtain filtrate B and residue;
(3) Mixing the filtrate A and the filtrate B, and sterilizing to obtain the final product;
the weight ratio of the mugwort in the step (1) to the mugwort in the step (2) is 3-6:1-2.
2. The mugwort mosquito repellent according to claim 1, wherein: the weight portion of the composition comprises: 30-35 parts of wormwood, 15-22 parts of mint, 15-22 parts of honeysuckle, 18-20 parts of star anise, 12-18 parts of cacumen biotae, 12-18 parts of ilex chinensis leaves, 12-18 parts of artemisia capillaris, 8-12 parts of eucommia ulmoides, 6-10 parts of achyranthes bidentata, 10-12 parts of litsea cubeba, 5-8 parts of Securinega suffruticosa and 6-8 parts of madder.
3. The mugwort mosquito repellent according to claim 1, wherein: the weight ratio of the wormwood to the holly leaf to the litsea cubeba is 30:15:11.
4. The mugwort mosquito repellent according to claim 1, wherein: the weight ratio of the wormwood to the madder is 30:7.
5. The method for preparing the mugwort mosquito repellent water according to any one of claims 1 to 4, which is characterized in that: the method comprises the following steps:
(1) Mixing folium Artemisiae Argyi, herba Menthae, flos Lonicerae, fructus Anisi Stellati, folium Platycladi, folium Ilicis Pubescentis, herba Artemisiae Scopariae and fructus Litseae, soaking in water, heating to boil, and filtering to obtain filtrate A and residue;
(2) Mixing the rest folium Artemisiae Argyi, herba Artemisiae Scopariae, eucommiae cortex, achyranthis radix, folium Securinegae Suffruticosae and radix Rubiae, soaking in water, boiling, and filtering to obtain filtrate B and residue;
(3) Mixing filtrate A and filtrate B, and sterilizing.
6. The method of manufacturing according to claim 5, wherein: the soaking time in the steps (1) and (2) is 30-60min.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103494749A (en) * | 2013-10-17 | 2014-01-08 | 林思哲 | Natural mosquito repellent |
| CN109105404A (en) * | 2018-11-13 | 2019-01-01 | 邓凤侃 | A kind of efficient mosquito repelling water and preparation method thereof |
| WO2022088282A1 (en) * | 2020-10-27 | 2022-05-05 | 苏州家和蚕业生物科技有限公司 | Method for preparing wormwood solution |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103494749A (en) * | 2013-10-17 | 2014-01-08 | 林思哲 | Natural mosquito repellent |
| CN109105404A (en) * | 2018-11-13 | 2019-01-01 | 邓凤侃 | A kind of efficient mosquito repelling water and preparation method thereof |
| WO2022088282A1 (en) * | 2020-10-27 | 2022-05-05 | 苏州家和蚕业生物科技有限公司 | Method for preparing wormwood solution |
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