CN115433670A - Cup separating processing system - Google Patents

Abstract

The invention discloses a cup separating treatment system, wherein a Y-axis guide rail is arranged on a longitudinal support frame, a first bearing plate and a second bearing plate are assembled on the Y-axis guide rail in a sliding manner, a switch cover device is arranged on the first bearing plate and used for automatically opening and closing a sample tube cover, a liquid transfer device is arranged on the second bearing plate and used for transferring a sample in a sample tube to a reaction plate, a tray assembly is arranged at the front end of an equipment base body through a lifting mechanism, a plurality of layers of trays distributed in the vertical direction are arranged on the tray assembly, each layer of trays are used for temporarily storing a sample frame, and a horizontal moving mechanism is arranged on a horizontal workbench and used for transferring the sample frame on the tray to a sample frame placing area or transferring the sample frame on the sample frame placing area to the tray. The invention has the beneficial effects that: can obviously improve the cup separating treatment efficiency of the prior cup separating treatment system.

Description

Cup separating processing system

Technical Field

The invention belongs to the technical field of biological detection, and particularly relates to a cup separating processing system.

Background

When virus nucleic acid detection is carried out, a sample to be detected is usually temporarily stored in a sample tube, and the sample needs to be transferred into each hole of a reaction plate one by one from the sample tube before biological detection analysis is carried out. In the early detection process, the above steps are completed manually, and the problems of time and labor waste, low efficiency, high error rate and the like exist.

In order to overcome the problems existing in manual operation, a fully-automatic cup separating processing system is developed, the cup separating processing system is mainly integrated with a code scanning mechanism, a cover opening and closing mechanism, a liquid transferring mechanism and the like, and after a sample rack is installed in the cup separating processing system, under the synergistic action of a moving module, the cup separating processing system can execute the work of information acquisition, cover opening and closing, sample liquid transfer and the like. However, in the prior art of the cup separation processing system, there are still problems of complex movement track of the module, long pipetting time, low efficiency of opening and closing the cover, and the need of manual intervention for loading and unloading the sample rack, so that the operation efficiency of the cup separation processing system is low, and the automation process still needs to be further improved.

Disclosure of Invention

In view of this, the present invention provides a cup separating processing system, which aims to improve the cup separating processing efficiency of the system.

In order to achieve the purpose, the technical scheme of the invention is as follows:

a cup separation processing system, comprising an equipment base body, characterized in that: the device base body is provided with a horizontal workbench and a longitudinal support frame positioned at the rear end of the horizontal workbench, a Y-axis guide rail is installed on the longitudinal support frame, a first bearing plate and a second bearing plate are assembled on the Y-axis guide rail in a sliding mode, wherein a switch cover device is arranged on the first bearing plate and used for automatically opening and closing a sample tube cover, and a liquid transfer device is arranged on the second bearing plate and used for transferring a sample in a sample tube to a reaction plate;

the automatic sample placing device is characterized in that a sample rack placing area, a reaction plate placing area, a TIP head box placing area and a TIP head recovery area are arranged on the horizontal workbench, a tray assembly is installed at the front end of the device base body through an elevating mechanism, multiple layers of trays distributed in the vertical direction are arranged on the tray assembly, each layer of trays are used for temporarily storing sample racks, a horizontal moving mechanism is arranged on the horizontal workbench and used for transferring the sample racks on the trays to the sample rack placing area or transferring the sample racks on the sample rack placing area to the trays.

Preferably, the cover opening and closing device comprises a base, a pipe cover grabbing mechanism is arranged on the base in a vertically sliding mode through a first Z-axis module, the pipe cover grabbing mechanism is used for clamping a pipe cover and can drive the pipe cover to rotate, a pipe body clamping assembly is integrated on the lower portion of the base and is used for clamping a sample pipe body, a horizontal moving module is arranged between the pipe body clamping assembly and the base, and the horizontal moving module is used for driving the pipe body clamping assembly to move in the horizontal direction and enabling the pipe body clamping assembly to be parked below the pipe cover grabbing mechanism;

the base is assembled on the first bearing plate in a sliding mode through the first X-axis module, and the longitudinal support frame is provided with the first Y-axis module and used for driving the first bearing plate to slide on the Y-axis guide rail.

Preferably, the number that the tube cap snatched mechanism and body centre gripping subassembly is two sets of, two sets of the tube cap snatchs the mechanism and is two sets of body centre gripping subassembly is in vertical direction one-to-one.

Preferably, the pipetting device comprises two groups of pipettors, and the distance between the two groups of pipettors is adjustable.

Preferably, a second X-axis guide rail is fixedly arranged on the second bearing plate, the liquid-moving device is provided with a first mounting plate and a second mounting plate, the first mounting plate and the second mounting plate are both assembled on the second X-axis guide rail in a sliding manner, and a driving mechanism is arranged between the first mounting plate and the second mounting plate and used for driving the second mounting plate to slide towards the direction far away from or close to the first mounting plate; the two groups of pipettors are respectively installed on the first installation plate and the second installation plate in a lifting mode through one group of second Z-axis modules;

and a second X-axis module is arranged on the second bearing plate and used for driving the first mounting plate and the second mounting plate to synchronously slide, and a second Y-axis module is arranged on the longitudinal support frame and used for driving the second bearing plate to slide on the Y-axis guide rail.

Preferably, a bracket component is fixedly arranged at the upper end of the rear side of the first mounting plate, the driving mechanism comprises a first belt pulley component and a first motor for driving the first belt pulley component to rotate, the first motor and the first belt pulley component are both arranged on the bracket component, a switching block is fixedly arranged at the upper end of the second mounting plate, and the switching block is fixedly connected with a belt of the first belt pulley component.

Preferably, the width limiting pieces are installed at the two ends of the tray, the guide sections inclining outwards are arranged at the upper ends of the width limiting pieces and the front ends of the width limiting pieces, and the positioning grooves are formed in the areas, corresponding to the two sets of width limiting pieces, of the tray.

Preferably, horizontal migration mechanism is including the translation subassembly, lifting means and the clamping jaw subassembly that connect gradually, wherein, the clamping jaw subassembly is used for lifting the sample frame, the translation subassembly is used for driving the clamping jaw subassembly and places the horizontal migration between district and the tray at the sample frame, lifting means is used for driving the clamping jaw subassembly and promotes the motion from top to bottom.

Preferably, the clamping jaw assembly comprises a support plate and clamping arms vertically connected to two ends of the support plate; the clamping arm is constructed into a rectangular plate-shaped structure, and the upper end of the clamping arm is provided with a positioning bulge.

Preferably, the pipe body clamping component comprises a sleeve plate, a supporting plate and two groups of clamping blocks which are just opposite to the clamping block, wherein the two groups of clamping blocks are used for clamping the pipe body, the supporting plate is located in two groups of lower parts of the clamping blocks and used for supporting the bottom of the pipe body, the sleeve plate is located in two groups of upper parts of the clamping blocks, and a through hole matched with the diameter of the pipe body is formed in the sleeve plate.

Compared with the prior art, the invention has the beneficial effects that:

1. the sample rack placing area, the reaction plate placing area, the TIP head box placing area and the TIP head recovery area are sequentially arranged along the Y-axis direction of the horizontal workbench, the switch cover device and the liquid transfer device share one group of Y-axis guide rails, and the cup separating processing system has high cooperative work efficiency.

2. Under the synergistic action of the system front end lifting mechanism, the tray assembly and the horizontal moving mechanism, the cup separation processing system can realize automatic replacement of the sample rack, can improve the processing efficiency of the cup separation processing system, and prolongs the unattended time of the system.

3. The switch cover device and the liquid-transferring device are arranged in two groups, so that the cup-separating processing capacity can be doubled.

4. The pipe body clamping assembly and the pipe cover grabbing mechanism of the cover opening and closing device are integrally arranged on a module, the pipe body clamping assembly and the pipe cover grabbing mechanism can synchronously move in a cup separating processing system, after a sample pipe is grabbed by the pipe cover grabbing mechanism, the pipe body clamping assembly moves outwards for a small stroke to clamp the pipe body, and then the pipe cover grabbing mechanism rotates to open the cover. The arrangement helps to simplify the moving stroke of the pipe body clamping assembly and improve the cover opening and closing efficiency.

5. The interval between two sets of pipettors of liquid-transfering device can be adjusted to this adapts to the pitch-row difference between two sample pipes and two sets of reaction holes, makes two sets of pipettors can carry out the dropping liquid operation in step, helps the branch cup efficiency of lift system.

Drawings

Fig. 1 is a schematic structural view of the cup separation processing system (the horizontal moving mechanism 9 and the tray assembly 2 on the front side are hidden);

FIG. 2 is another schematic diagram of the cup separation processing system;

FIG. 3 is a partial schematic structural view showing the positional relationship among the elevating mechanism 8, the horizontal movement mechanism 9 and the tray assembly 2 in the cup separation processing system;

FIG. 4 is a schematic structural view of the tray assembly 2;

fig. 5 is a sectional view showing the connection relationship of the tray assembly 2 and the elevating mechanism 8;

fig. 6 is a schematic structural view of the horizontal movement mechanism 9;

fig. 7 is a reference view showing a state in which the grip claw assembly 9c grips the sample rack e;

fig. 8 is a schematic structural view (front side view) of the opening and closing cover device 5;

fig. 9 is a schematic structural view (back side view) of the opening and closing cover device 5;

fig. 10 to 12 are side views of the opening and closing cover device 5 in three different states, respectively. Wherein, fig. 10 shows the state of the tube cover grabbing mechanism 5c grabbing the sample tube; fig. 11 shows a state where the tube body holding member 5d holds the sample tube; fig. 12 shows the tube clamping assembly 5d moved horizontally to the front-most position.

Fig. 13 is a perspective view (front side view) of the pipetting device 6;

FIG. 14 is a schematic perspective view (rear side view) of the pipetting device 6;

FIG. 15 is an enlarged view of a portion of FIG. 14 at I;

FIG. 16 is a reference view (outside view) showing a state in which the pipetting device 6 is used in the cup separation processing system;

fig. 17 is a reference view (inside view) of a state in which the pipetting device 6 is used in the cup dividing processing system.

Detailed Description

The present invention will be further described with reference to the following examples and the accompanying drawings.

As shown in FIG. 1, a cup separation processing system comprises an apparatus base 1, wherein the apparatus base 1 is provided with a horizontal workbench 1a and a longitudinal support frame 1b located at the rear end of the horizontal workbench 1a, the longitudinal support frame 1b is provided with a Y-axis guide rail 7,Y and an axis guide rail 7 which are slidably assembled with a first bearing plate 3 and a second bearing plate 4, the first bearing plate 3 is provided with a switch cover device 5 for automatically opening and closing a tube cover g of a sample tube k, and the second bearing plate 4 is provided with a liquid transfer device 6 for transferring the sample in the sample tube to a reaction plate m. The length direction of horizontal table 1a is equipped with sample frame in proper order and places district a, reaction plate and place district b, TIP head box and place district c and TIP head recovery district d, and it can be seen from combining figure 2 that the sample frame is placed district a and is placed sample frame e, and reaction plate is placed district b and is placed reaction plate m, and TIP head box is placed district c and is placed TIP head box n, and TIP head recovery district d has placed collection box p.

As shown in fig. 3, the tray assembly 2 is installed at the front end of the device base body 1 through the lifting mechanism 8, and it can be seen from fig. 4 that a plurality of layers of trays 2a are arranged on the tray assembly 2, the trays 2a of each layer are distributed in an array manner along the vertical direction, and the trays 2a are used for temporarily storing the sample rack e. In the present embodiment, the number of layers of the tray 2a is 3. The horizontal table 1a is provided with a horizontal movement mechanism 9 for transferring the sample rack e on the tray 2a to the sample rack placement area a, or transferring the sample rack on the sample rack placement area a to the tray 2a. As can be seen from fig. 6, the horizontal moving mechanism 9 includes a translation assembly 9a, a lifting assembly 9b, and a clamping jaw assembly 9c, which are connected in sequence, wherein the clamping jaw assembly 9c is used for lifting the sample rack e, the translation assembly 9a is used for driving the clamping jaw assembly 9c to move horizontally between the sample rack placing area a and the tray 2a, and the lifting assembly 9b is used for driving the clamping jaw assembly 9c to move up and down.

3 groups of sample frames e are preassembled on the tray assembly 2, the lifting mechanism 8 drives the tray assembly 2 to move up and down, so that the tray 2a on one layer is flush with the sample frame placing area a in the same height, then the translation assembly 9a drives the clamping jaw assembly 9c to move to the lower side of the supporting lugs e1 at the two ends of the sample frame e, the lifting assembly 9b drives the clamping jaw assembly 9c to move upwards to lift the sample frame e, then the translation assembly 9a drives the clamping jaw assembly 9c to move to the sample frame placing area a, and finally the lifting assembly 9b drives the clamping jaw assembly 9c to move downwards to place the sample frame e in the sample frame placing area a. The sample rack e can be transferred from the sample rack storage area a to the tray 2a by reversing the above process. Therefore, under the synergistic action of the lifting mechanism 8, the tray component 2 and the horizontal moving mechanism 9, the cup separation processing system can realize automatic replacement of the sample rack, so that the cup separation processing system has higher working efficiency.

Further, referring to fig. 6, the translation assembly 9a includes a base 9a1 fixedly mounted on the horizontal table 1a, the base 9a1 is a long strip-shaped plate-shaped structure, a supporting cantilever 9a2 is slidably connected to an inner side of the base 9a1, a belt driving assembly 9a3 is disposed between the supporting cantilever 9a2 and the base 9a1, the belt driving assembly 9a3 is composed of a motor, a pulley and a belt, which are sequentially connected, the supporting cantilever 9a2 is fixedly connected to one side of the belt, and accordingly, the motor operates to drive the supporting cantilever 9a2 to slide along a length direction of the base 9a 1. Further, in order to ensure the stability of the support cantilever 9a2, two sets of guide rails 9a4 are arranged between the support cantilever 9a2 and the base 9a1, and the two sets of guide rails 9a4 are symmetrically arranged in the width direction of the base 9a 1. The belt is arranged between two sets of guide rails 9a 4.

The lifting assembly 9b comprises a holding seat 9b5 fixedly assembled at the far end of the supporting cantilever 9a2, a connecting plate 9b3 is arranged on the clamping jaw assembly 9c, the connecting plate 9b3 is assembled in the holding seat 9b5 in a vertically sliding mode through two guide columns 9b6, a nut sleeve 9b4 is embedded in the middle of the connecting plate 9b3, a lifting motor 9b1 is fixedly arranged at the lower end of the holding seat 9b5, a screw rod 9b2 is connected to an output shaft of the lifting motor 9b1, and the screw rod 9b2 is in threaded connection with the nut sleeve 9b 4. Based on this, the lifting motor 9b1 works to drive the clamping jaw assembly 9c to move up and down in a lifting mode.

As shown in fig. 5, in this embodiment, the lifting mechanism 8 specifically includes a fixed frame 8a, a tray support 8b is slidably mounted on one side of the fixed frame 8a, the tray support 8b can slide in the height direction relative to the fixed frame 8a, a lifting motor 8c is mounted on the lower portion of the fixed frame 8a through a horizontal extending plate 8d, the lifting motor 8c is used for driving the tray support 8b to slide up and down, the tray assembly 2 is fixedly mounted on the tray support 8b, and based on this, the lifting motor 8c can drive the tray assembly 2 to move up and down when working. The working principle that the lifting motor 8c drives the tray support 8b to move up and down is a lead screw nut lifting principle, the transmission structure of the lifting motor is the prior mature technology, and further description is omitted here. When the lifting mechanism 8 is installed, the fixing frame 8a is directly or indirectly fixedly connected with the horizontal workbench 1 a.

As shown in fig. 6, the clamping jaw assembly 9c includes a supporting plate 9c1 and clamping arms 9c2 vertically connected to two ends of the supporting plate 9c1, the clamping arms 9c2 are configured as a rectangular plate-shaped structure, as can be seen from fig. 3 and 7, two ends of the sample rack e are provided with outwardly extending support lugs e1, when the sample rack e is clamped, the upper ends of the clamping arms 9c2 are supported at the lower sides of the support lugs e1, and at this time, the clamping jaw assembly 9c moves upward to lift the sample rack e upward. Further, the upper end of the clamping arm 9c2 is provided with a positioning protrusion 9c3, the positioning protrusion 9c3 is matched with a positioning hole e2 in the support lug e1, on one hand, the sample rack can be prevented from shaking in the transferring process, the stability is better, on the other hand, the sample rack e which is placed into the system at each time can be guaranteed to have higher position precision, and better reference guarantee is provided for the subsequent operation of the cup separating processing system.

As shown in fig. 4, width limiting pieces 2b are mounted at both ends of the tray 2a, guide sections 2b1 inclined outward are disposed at the upper end and the front end of the width limiting pieces 2b, a bending section 2b2 extending inward is disposed at the rear end of the width limiting pieces 2b, and a positioning groove 2a1 is disposed in a region of the tray 2a between two corresponding sets of width limiting pieces 2 b. By the design, when the sample holder e is preassembled, the sample holder e can be well guided to be placed in the positioning groove 2a1, and for the whole system, an accurate relative position is equivalently provided, so that the positioning protrusions 9c3 on the clamping arms 9c2 can be ensured to be accurately butted with the positioning holes e2 of the sample holder e. Further, referring to fig. 7, the upper end of the positioning protrusion 9c3 is a tapered structure, and the positioning protrusion 9c3 is guided into the positioning hole e2 by the tapered structure, so that almost no gap is formed between the main body of the positioning protrusion 9c3 and the positioning hole e2, and the transfer stability and the butt joint accuracy of the sample rack are further improved. Similarly, in order to further ensure the accuracy of placing the sample rack e in the sample rack placing area a, the sample rack placing area a is also provided with a positioning groove, a width positioning plate and other structures.

As shown in fig. 1 again, after the sample rack e is placed in the sample rack placement area a by the horizontal movement mechanism 9, the opening and closing operation of the lid is performed by the lid opening and closing device 5, and the liquid taking operation is performed by the liquid-moving device 6, so as to realize the cup-dividing process, that is: the sample in sample tube k is transferred to the hole of reaction plate m.

In the present embodiment, the specific implementation structure of the opening and closing cover device 5 is as follows:

referring to fig. 8 and 9, the cap opening and closing device 5 includes a base 5a, and a cap gripping mechanism 5c and a tube body clamping assembly 5d are disposed on the base 5a, wherein the cap gripping mechanism 5c is slidably mounted on one side of the base 5a through a first Z-axis module 5b, and the cap gripping mechanism 5c is used for clamping the cap g and driving the cap g to rotate. The tube body clamping component 5d is used for clamping a tube body f of the sample tube, a horizontal moving module 5e is arranged between the tube body clamping component 5d and the base 5a, and the horizontal moving module 5e is used for driving the tube body clamping component 5d to move along the horizontal direction and enabling the tube body clamping component 5d to be parked below the tube cover grabbing mechanism 5 c.

Based on above structure, the tube cap snatchs mechanism 5c snatchs the back with the sample tube, and horizontal migration module 5e drive body clamping components 5d outwards removes and snatchs mechanism 5c below from the tube cap, then first Z axle module 5b drive tube cap snatchs mechanism 5c downstream, makes the sample tube get into body clamping components 5 d's centre gripping within range, and body clamping components 5d presss from both sides body f tightly, and the tube cap snatchs mechanism 5c and rotates tube cap g at last and can realize uncapping.

Snatch mechanism 5c integration on a module with body clamping component 5d and tube cap, the tube cap snatchs mechanism 5c and snatchs the back with the sample tube, and body clamping component 5d only need outwards remove less stroke and can clip the body, and to dividing cup processing system, such setting has higher switch lid efficiency undoubtedly. Because present tube cap clamping structure and body clamping structure do not set up together, specifically do: the pipe body clamping structure is fixedly installed at a certain position of the cup separating processing system and cannot move together with the pipe cover clamping structure, so that the pipe cover clamping structure needs to move to the position of the pipe body clamping structure after grabbing a sample, the stroke involved in the process is far, and the efficiency of opening and closing the cover is invisibly reduced. Therefore, body clamping component 5d and tube cap snatch mechanism 5c and integrate on a module, and both can wholly remove simultaneously, have higher switch lid efficiency.

Further, referring to fig. 1, the base 5a is slidably mounted on the first bearing plate 3 through a first X-axis module 3a, and the longitudinal support frame 1b is provided with a first Y-axis module 7a for driving the first bearing plate 3 to slide on the Y-axis guide 7. Based on this, the first X-axis module 3a and the first Y-axis module 7a operate to drive the movement of the opening and closing cover device 5 in the X direction and the Y direction.

In this embodiment, please refer to fig. 8, the tube clamping assembly 5d includes two sets of clamping blocks 5d3 facing each other, and the two sets of clamping blocks 5d3 open and close to each other to clamp and release the tube f. The opening and closing movement of the two groups of clamping blocks 5d3 can be controlled by a motor, and can also be controlled by pneumatic, hydraulic and other modes. Two sets of grip blocks 5d 3's below is provided with layer board 5d2, the top is provided with lagging 5d1, be equipped with the through-hole i that suits with body f diameter on the lagging 5d1, the in-process of body centre gripping subassembly 5d centre gripping sample pipe, body f bottom sprag is on layer board 5d2, body f middle part cover is in through-hole i, when body centre gripping subassembly 5d appears the clamping-force slack because of unexpected outage, the sample pipe also can continuously keep vertical gesture, can not take place the body slope, the skew or the condition such as drop downwards.

Further, in order to support the bottom of the pipe body f more stably, a circular groove h is formed at the upper portion of the support plate 5d2, which is adapted to the structure of the bottom of the pipe body f, and the center line of the circular groove h is aligned with the center line of the through-hole i. As shown in fig. 8, the tube clamping assembly 5d further has a supporting base plate 5d4, in this embodiment, the supporting plate 5d2 is fixed on the lower side of the front end of the supporting base plate 5d4, and the front end of the supporting base plate 5d4 is formed with a circular hole, which is a circular groove h on the upper portion of the supporting plate 5d 2. In addition, the provision of the support floor 5d4 also facilitates the sliding connection between the tube gripping assembly 5d and the base 5 a.

Referring to fig. 9, the base 5a includes a vertical supporting plate 5a1 and a supporting surrounding frame 5a2 located at a lower end of the vertical supporting plate 5a1, the cap grabbing mechanism 5c is disposed at one side of the vertical supporting plate 5a1, the supporting surrounding frame 5a2 has a receiving space therein, and the tube clamping assembly 5d is slidably disposed in the receiving space. The structure is reasonable in design, the movement requirements of the subassembly of each part are met, and the compactness of the whole structure is ensured.

Referring to fig. 9, in the embodiment, the horizontal moving module 5e specifically includes a sliding rail assembly 5e1, a second pulley assembly 5e2 and a belt motor 5e3, in order to facilitate assembly, a fixing plate 5a3 is disposed on the upper portion of the supporting enclosure frame 5a2, the second pulley assembly 5e2 and the belt motor 5e3 are both assembled on the fixing plate 5a3, and the supporting base plate 5d4 is fixedly connected to a belt k of the second pulley assembly 5e2 through a locking block j. As can be seen in fig. 4, the slide rail assembly 5e1 is installed between the support bottom plate 5d4 and the bottom of the support enclosure 5a 2. Based on this, the belt motor 5e3 works to drive the supporting bottom plate 5d4 to slide back and forth in the supporting enclosure frame 5a2, so as to realize the horizontal movement of the pipe clamping component 5 d.

As shown in fig. 10 again, the tube cover gripping mechanism 5c includes a claw portion 5c1 and a claw portion driving motor 5c2, and the claw portion 5c1 is openable or closable for gripping the tube cover g from the outside thereof; the claw portion driving motor 5c2 is used to drive the claw portion 5c1 to open or close. The claw part 5c1 comprises at least two fingers which are arranged in parallel along the vertical direction, and the fingers can approach to or move away from each other towards the center, so that the pipe cover can be clamped or loosened. The inside rotating electrical machines that still is equipped with of tube cap snatchs mechanism 5c, and after claw 5c1 centre gripping tube cap, the rotating electrical machines work can drive claw 5c1 and tube cap g and rotate as a whole to realize the screw capping operation. The specific structure of the tube cap grabbing mechanism 5c for performing cap grabbing and cap screwing belongs to the prior mature technology, and is not described in detail here.

As shown in fig. 8, in order to improve the efficiency, the number of the tube cap grabbing mechanisms 5c and the number of the tube body clamping assemblies 5d are two, and the two sets of the tube cap grabbing mechanisms 5c correspond to the two sets of the tube body clamping assemblies 5d in the vertical direction one by one. For easy to assemble, two sets of body centre gripping subassembly 5d sharing a supporting baseplate 5d4. In order to stably hold the sample tube, the holding block 5d3 is made of a metal material, and the inner side thereof is of an arc-shaped structure and covered with an anti-slip layer.

In the present embodiment, the pipetting device 6 is embodied as follows:

referring to fig. 13, the structure of the liquid-moving device 6 includes a first mounting plate 6a and a second mounting plate 6b which are arranged side by side, a liquid-moving device 61 is arranged on the front sides of the first mounting plate 6a and the second mounting plate 6b, as can be seen from fig. 14 and 15, a first slider 62 is arranged on the rear side of the first mounting plate 6a, a second slider 63 is arranged on the rear side of the second mounting plate 6b, and as can be seen from fig. 16 and 17, a second X-axis guide rail 4a is fixedly arranged on the second bearing plate 4, the first mounting plate 6a is assembled on the second X-axis guide rail 4a through the first slider 62, the second mounting plate 6b is assembled on the second X-axis guide rail 4a through the second slider 63, a second X-axis module 4b is arranged on the second bearing plate 4 and is used for driving the first mounting plate 6a and the second mounting plate 6b to slide synchronously, and a second Y-axis module 7b is arranged on a longitudinal support frame 1b of the apparatus base 1 and is used for driving the second bearing plate 4 to slide on the Y-axis guide rail 7. Based on this, the second X-axis module 4b and the second Y-axis module 7b operate to drive the movement of the liquid transfer device 6 in the system X direction and Y direction.

Referring to fig. 13, the pipettes 61 are all installed on the front sides of the first mounting plate 6a and the second mounting plate 6b through the second Z-axis module 6d, and the second Z-axis module 6d can drive the pipettes 61 to move up and down along the corresponding mounting plates, so as to conveniently take liquid in the sample tube and drip liquid to the reaction plate m. The second Z-axis module 6d employs a conventional linear motion module. In this embodiment, the pipette 61 is used for taking and dropping liquid, and has a needle 61a at its lower end, and during the operation of the system, the needle 61a is sleeved on a TIP head 61b to perform the taking and dropping operation. The use of TIP for extracting liquid from the pipette 61 is well known in the art and the working principle thereof will not be described herein.

As shown in fig. 13, a driving mechanism 6c is disposed between the first mounting plate 6a and the second mounting plate 6b, and the driving mechanism 6c is configured to drive the first mounting plate 6a and the second mounting plate 6b to move toward or away from each other, so as to change a distance between the two sets of pipettes 61. In dividing cup processing system, the interval of two adjacent sample tubes on sample frame e is greater than the interval of two adjacent reaction holes on reaction plate m, and two sets of pipettors absorb sample solution simultaneously in two sample tubes after, must control one of them group pipettor to the reaction hole dropping liquid earlier, then control another group pipettor to the reaction hole dropping liquid, and two sets of pipettors need carry out the dropping liquid operation alone promptly, divide cup efficiency lower. Therefore, under the driving action of the driving mechanism 6c, the distance between the two sets of pipettors 61 can be adjusted to adapt to the pitch difference between the two sample tubes and the two sets of reaction holes, so that the two sets of pipettors of the pipetting device 6 can synchronously execute the dropping operation, and the cup dividing efficiency of the system is improved.

As shown in fig. 13, in order to conveniently set the driving mechanism 6c, a bracket assembly 6a1 is fixedly arranged at the upper end of the rear side of the first mounting plate 6a, the driving mechanism 6c includes a first motor 6c2 and a first pulley assembly 6c1 both mounted on the bracket assembly 6a1, a switching block 6b1 is fixedly arranged at the upper end of the second mounting plate 6b, and the switching block 6b1 is fixedly connected with the belt of the first pulley assembly 6c 1. Based on this, first motor 6c2 drive first pulley assembly 6c1 and rotate, and the belt of first pulley assembly 6c1 can drive second mounting panel 6b and slide on second X axle guide rail 4a, and then realizes the adjustment of two sets of pipettors 61 interval.

Referring to fig. 15, the bracket assembly 6a1 is composed of a motor base u and a supporting sheet v extending outward from one end of the motor base u, the first motor 6c2 is installed on the motor base u, one of the belt wheels of the first belt wheel assembly 6c1 is fixedly sleeved on the output shaft of the first motor 6c2, and the other belt wheel is rotatably installed at one end of the supporting sheet v away from the motor base u. So design, have rationally distributed advantage, can make things convenient for switching piece 6b1 to be connected with the belt. In this embodiment, the left end of the support sheet v is provided with a waist-shaped hole v1, and is connected with the motor base u through the waist-shaped hole v1, so that the belt tension of the first belt pulley assembly 6c1 can be conveniently adjusted.

Further, motor cabinet u right-hand member still fixed mounting has the photoelectric sensor installation piece w of outside extension, photoelectric sensor installation piece w is just to setting up with switching piece 6b1, install two sets of photoelectric sensor 64 on the photoelectric sensor installation piece w, be equipped with the light blocking piece 65 that suits with photoelectric sensor 64 on the switching piece 6b1, two sets of photoelectric sensor 64 distribute along the sliding direction of second mounting panel 6b, the position that light blocking piece 65 reachd two sets of photoelectric sensor 64 corresponds the maximum interval and the minimum interval of two sets of pipettors 61 respectively. Separately design photoelectric sensor installation piece w and backing sheet v, can guarantee that photoelectric sensor installation piece w has relatively stable position relation, can not change along with backing sheet v's regulation, and then ensure the accurate nature of photoelectric sensor 64 position judgement.

The working steps of the cup separating processing system provided by the invention are as follows:

1. referring to fig. 3, a group of sample holders e is automatically placed in the sample holder placing area a under the cooperation of the lifting mechanism 8, the tray assembly 2 and the horizontal moving mechanism 9.

2. Referring to fig. 10, the cover opening and closing device 5 starts to operate, the horizontal moving module 5e retracts the tube clamping assembly 5d to the retracted position, and then the tube cover gripping mechanism 5c grips the sample tube under the cooperation of the first X-axis module 3a, the first Y-axis module 7a and the first Z-axis module 5 b.

3. Referring to fig. 11, the horizontal moving module 5e drives the tube clamping assembly 5d to move to a position below the tube cap grabbing mechanism 5c, then the first Z-axis module 5b drives the tube cap grabbing mechanism 5c to move downward, so that the sample tube passes through the sleeve plate 5d1 and enters between the two sets of clamping blocks 5d3, and then the two sets of clamping blocks 5d3 clamp the tube f.

4. The rotating motor inside the tube cover grabbing mechanism 5c drives the tube cover g to rotate, so that the cover opening operation is completed.

5. Referring to fig. 12, the horizontal moving module 5e continues to drive the tube holding assembly 5d to move forward, and then the liquid-moving device 6 sucks the sample in the tube f, and the liquid-moving device 6 moves to the position of the reaction plate m to drop the sucked sample into the hole of the reaction plate m.

6. The horizontal movement module 5e drives the pipe body clamping assembly 5d to return to the position below the pipe cover grabbing mechanism 5c, the first Z-axis module 5b drives the pipe cover grabbing mechanism 5c to move downwards, and the rotating motor inside the pipe cover grabbing mechanism 5c drives the pipe cover g to rotate to complete the cover closing operation.

7. The tube body clamping assembly 5d releases the clamping force, and the tube cap grabbing mechanism 5c puts the sample tube back to the sample rack 10 under the cooperative action of the first X-axis module 3a, the first Y-axis module 7a and the first Z-axis module 5 b.

Finally, it should be noted that the above-mentioned description is only a preferred embodiment of the present invention, and those skilled in the art can make various similar representations without departing from the spirit and scope of the present invention.

Claims (10)

1. A cup separation processing system comprises a device base body (1), and is characterized in that: the device base body (1) is provided with a horizontal workbench (1 a) and a longitudinal support frame (1 b) located at the rear end of the horizontal workbench (1 a), a Y-axis guide rail (7) is installed on the longitudinal support frame (1 b), a first bearing plate (3) and a second bearing plate (4) are assembled on the Y-axis guide rail (7) in a sliding mode, a switch cover device (5) is arranged on the first bearing plate (3) and used for automatically opening and closing a sample tube cover, and a liquid transfer device (6) is arranged on the second bearing plate (4) and used for transferring a sample in a sample tube to a reaction plate;

be equipped with sample frame on horizontal table (1 a) and place district (a), reaction plate and place district (b), TIP head box and place district (c) and TIP head recovery district (d), equipment base member (1) front end is installed tray subassembly (2) through elevating system (8), is equipped with on tray subassembly (2) along the multilayer tray (2 a) of vertical direction distribution, each layer tray (2 a) all are used for keeping in the sample frame, be equipped with horizontal migration mechanism (9) on horizontal table (1 a) for shift to the sample frame on tray (2 a) sample frame place district (a), or shift to tray (2 a) with the sample frame on sample frame place district (a).

2. The split cup processing system of claim 1, wherein: the cover opening and closing device (5) comprises a base (5 a), a pipe cover grabbing mechanism (5 c) is installed on the base (5 a) through a first Z-axis module (5 b) in a vertically sliding mode, the pipe cover grabbing mechanism (5 c) is used for clamping a pipe cover and can drive the pipe cover to rotate, a pipe body clamping assembly (5 d) is integrated on the lower portion of the base (5 a) and is used for clamping a sample pipe body, a horizontal moving module (5 e) is arranged between the pipe body clamping assembly (5 d) and the base (5 a), the horizontal moving module (5 e) is used for driving the pipe body clamping assembly (5 d) to move in the horizontal direction, and the pipe body clamping assembly (5 d) can be stopped below the pipe cover grabbing mechanism (5 c);

the base (5 a) is assembled on the first bearing plate (3) in a sliding mode through a first X-axis module (3 a), and a first Y-axis module (7 a) is arranged on the longitudinal supporting frame (1 b) and used for driving the first bearing plate (3) to slide on the Y-axis guide rail (7).

3. The split cup processing system of claim 2, wherein: the number of the pipe cap grabbing mechanisms (5 c) and the number of the pipe body clamping assemblies (5 d) are two, and the pipe cap grabbing mechanisms (5 c) and the pipe body clamping assemblies (5 d) correspond to one another in the vertical direction.

4. The split cup processing system of claim 3, wherein: the pipetting device (6) comprises two groups of pipettors (61), and the distance between the two groups of pipettors (61) is adjustable.

5. The split cup processing system of claim 4, wherein: a second X-axis guide rail (4 a) is fixedly arranged on the second bearing plate (4), the liquid transfer device (6) is provided with a first mounting plate (6 a) and a second mounting plate (6 b), the first mounting plate (6 a) and the second mounting plate (6 b) are both assembled on the second X-axis guide rail (4 a) in a sliding mode, and a driving mechanism (6 c) is arranged between the first mounting plate (6 a) and the second mounting plate (6 b) and used for driving the second mounting plate (6 b) to slide towards the direction far away from or close to the first mounting plate (6 a); the two groups of pipettors (61) are respectively arranged on the first mounting plate (6 a) and the second mounting plate (6 b) in a lifting way through one group of second Z-axis modules (6 d);

and a second X-axis module (4 b) is arranged on the second bearing plate (4) and used for driving the first mounting plate (6 a) and the second mounting plate (6 b) to synchronously slide, and a second Y-axis module (7 b) is arranged on the longitudinal support frame (1 b) and used for driving the second bearing plate (4) to slide on the Y-axis guide rail (7).

6. The split-cup processing system of claim 5, wherein: first mounting panel (6 a) rear side upper end has set firmly bracket component (6 a 1), actuating mechanism (6 c) include first pulley subassembly (6 c 1) and drive first pulley subassembly (6 c 1) pivoted first motor (6 c 2), first motor (6 c 2) and first pulley subassembly (6 c 1) all set up on bracket component (6 a 1), second mounting panel (6 b) upper end has set firmly switching piece (6 b 1), this switching piece (6 b 1) and the belt fixed connection of first pulley subassembly (6 c 1).

7. The split cup processing system of claim 1, wherein: the spacing piece of width (2 b) is all installed at the both ends of tray (2 a), spacing piece of width (2 b) upper end and front end all are equipped with direction section (2 b 1) that leans out, tray (2 a) are equipped with constant head tank (2 a 1) corresponding the region between two sets of spacing pieces of width (2 b).

8. The split cup processing system of claim 1, wherein: horizontal migration mechanism (9) are including translation subassembly (9 a), lifting means (9 b) and clamping jaw subassembly (9 c) that connect gradually, wherein, clamping jaw subassembly (9 c) are used for lifting the sample frame, translation subassembly (9 a) are used for driving clamping jaw subassembly (9 c) and place horizontal migration between district (a) and tray (2 a) at the sample frame, lifting means (9 b) are used for driving clamping jaw subassembly (9 c) and promote the motion from top to bottom.

9. The split cup processing system of claim 8, wherein: the clamping jaw assembly (9 c) comprises a supporting plate (9 c 1) and clamping arms (9 c 2) vertically connected to two ends of the supporting plate (9 c 1); the clamping arm (9 c 2) is of a rectangular plate-shaped structure, and the upper end of the clamping arm is provided with a positioning bulge (9 c 3).

10. The split cup processing system of claim 2, wherein: body centre gripping subassembly (5 d) is including lagging (5 d 1), layer board (5 d 2) and two sets of grip block (5 d 3) just to setting up, wherein, two sets of grip block (5 d 3) are used for the centre gripping body, layer board (5 d 2) are located two sets of grip block (5 d 3) below for hold the body bottom, lagging (5 d 1) are located two sets of grip block (5 d 3) top is equipped with through-hole (i) that suits with the body diameter on lagging (5 d 1).

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