CN115429846A

CN115429846A - Medicine for preventing and treating cataract and myopia and its preparing method

Info

Publication number: CN115429846A
Application number: CN202110606014.8A
Authority: CN
Inventors: 谢坤
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-06-01
Filing date: 2021-06-01
Publication date: 2022-12-06

Abstract

A medicine for preventing and treating cataract and myopia is prepared from water-soluble extract and oil-soluble extract of microalgae (including Dunaliella salina, chlorella, haematococcus pluvialis, and Spirulina) or similar composition, and Chinese medicinal materials including rhizoma Ligustici Chuanxiong extract, herba Andrographitis extract, radix et caulis Opuntiae Dillenii extract, glycyrrhrizae radix extract, radix Ophiopogonis extract, herba Portulacae extract, herba Selaginellae extract, capsici fructus extract, folium Eucalypti Globueli extract, fructus Piperis extract, borneolum Syntheticum extract, sodium hyaluronate, polyethylene glycol, humectant, and deionized water. The eye drop prepared by the method has no side effect, has the effects of clearing heat, reducing internal heat, detoxifying, resisting inflammation, improving eyesight, removing nebula, promoting blood circulation and removing blood stasis, and has good effects on treating myopia, cataract, muscae volitantes, epiphora induced by wind, asthenopia and glaucoma.

Description

Medicine for preventing and treating cataract and myopia and its preparing method

Technical Field

The invention relates to an eye drop, in particular to a medicine for preventing and treating cataract and myopia and a preparation method thereof.

Background

With the increasing aging population and the difference of living habits and environments of modern people, the eyes are excessively used for a long time by computers, mobile phones, books or other eyes, and more importantly, the living environment with high pressure for a long time, so that ciliary muscles, crystalline lenses, eyeballs, peripheral capillaries, nerves and the like of the eyes are easy to generate a large amount of enriched free radicals, and eye diseases such as myopia or cataract, glaucoma, muscae volitantes and the like occur. The old people are caused by falling injury with various diseases due to vision loss. According to the records of related documents, the myopia and cataract of the agricultural era are found to be obviously less than those of the existing industrial era, especially the modern industry and information technology cannot be separated from mobile phones and computers, the working time is long, and the eyes are used excessively; this is the root cause of myopia and cataract in modern people. Numerous medical studies and clinical trials have demonstrated that free radical damage to human cells is a source of ten thousand diseases. A radical is a species lacking electrons (unsaturated electron species). Free radicals compete for electrons of human cells throughout the human body, and if electrons of cellular protein molecules are deprived, proteins are connected with branched chains to be alkylated, and malformed molecules are formed, so that various diseases of the human body can occur.

The existing common methods for treating eye diseases such as myopia, cataract and the like have modes of medicament treatment, operation treatment and the like, wherein the operation treatment has damage or sequelae on a human body and has certain risk; however, most of the existing drug therapies adopt atropine eyedrops or eye ointments, but the effect is not obvious, the preparation process is unstable, and a large amount of free radicals such as eyeballs, peripheral capillaries and nerves are difficult to eliminate. In order to eliminate a large amount of free radicals generated by overuse of eyes and environmental factors, according to the records of related data, blueberry, lycium ruthenicum mill, mulberry, vitamin E, vitamin C or high-efficiency substances containing selenium and the like for resisting free radicals have certain effects on myopia and cataract, but the effects are not obvious. The current therapy for treating the myopia mainly comprises laser beating or wearing myopia glasses. The aspect of medicine treatment is also disclosed in the literature, see the Chinese patent application of 201610878461.8 entitled "eyedrops for treating myopia and preparation method thereof" (publication number CN 106344733A); reference may also be made to the chinese invention patent application publication No. 201811596176.2, an eye drop for external use for improving myopia (publication No. CN 111346152A). The most important aspect of the long-term medical history in China is to pay attention to the relationship between eyes and viscera, meridians, qi, blood and body fluids when treating eye diseases. The Ling Shu & big Huo Lun: essential qi of five zang-organs and six fu-organs is the essence by injecting upward to the eyes. The seminal nest is the eye, the essence of bone is the pupil, the essence of tendon is the black eye, the essence of blood is the collateral, the essence of nest qi is the white eye, the essence of muscle is the restraint, it wraps up the essence of blood and qi of tendons and bones, and the blood and vessels are involved, and the above belongs to the brain and later comes out of the neck. The meridians and collaterals are the functions of circulating qi and blood throughout the body and communicating the exterior, interior and exterior, and connecting the zang-fu organs. Lingshu, the chapter of visceral manifestation with pathogenic factors: the blood and qi of the twelve main meridians, three hundred and six fifteen collaterals, all go up to the face to open orifices, and the essence and yang qi go up to the eyes to form essence. All this means that the eyes and zang-fu organs are connected through the meridians and collaterals, and they are in organic connection. The visual function of the eye is maintained only by the continuous transmission of blood and air through the meridians.

Therefore, the inventor thinks that the excessive eye and environmental factors and the functional aging meridian obstruction of modern people are the root causes causing the abundant accumulation of free radicals such as ciliary muscle, crystalline lens, eyeball and peripheral microvasculature and nerves. Furthermore, the excessive amount of free radicals can cause the fundamental causes of juvenile myopia, senile cataract, muscae volitantes, glaucoma and presbyopia just because the ciliary muscle of the eye can not stretch flexibly due to the abundant enrichment of the free radicals, the spasm of the eye and the peripheral muscle, the blockage of blood vessels, the lens can not obtain nutrition and the metabolic waste can not be discharged smoothly. The therapeutic medicine is prepared by combining Chinese medicine with western medicine. The invention was made.

Disclosure of Invention

The invention aims to solve the defects of the existing eye drops and provide a medicine for preventing and treating cataract and myopia and a preparation method thereof.

The invention realizes the purpose of a medicine for preventing and treating cataract and myopia and a preparation method thereof, and the medicine is prepared by matching a water-soluble extract and an oil-soluble extract of microalgae (comprising dunaliella salina, chlorella vulgaris, haematococcus pluvialis and spirulina) or similar compositions with a traditional Chinese medicine ligusticum chuanxiong hort extract, an andrographis paniculata extract, a large flower cactus extract, a liquorice extract, an ophiopogon root extract, a purslane extract, a selaginella tamariscina extract, a capsicum extract, a eucalyptus leaf extract, a kava extract, a borneol extract, sodium hyaluronate, polyethylene glycol, a humectant and deionized water. The microalgae oil-soluble extract is carotenoid, phycocyanin, chlorophyll ester and glycerate, the use amount of the microalgae oil-soluble extract in the eye drop is 0.01-100ppm, and PVP is added before use to make the fat-soluble carotenoid, phycocyanin ester, chlorophyll ester and glycerate 'dissolved' in water; the microalgae water soluble extract contains glycerol, vitamin C, vitamin B group, amino acids, etc. with concentration of 0.01-100ppm in eye drop, and can be mixed with oil soluble extract before use and directly dissolved in water; the dosage of each traditional Chinese medicine extract is 1-10%.

Further, sodium hyaluronate and polyethylene glycol are also included, and the sodium hyaluronate and the polyethylene glycol respectively account for 0.01 to 5 percent of the total weight.

Further, the sodium hyaluronate has a low molecular weight of 1000 daltons, and the polyethylene glycol is polyethylene glycol 400. The humectant is at least one of butanediol, glycerol, polyalcohol or propylene glycol.

A medicine for preventing and treating cataract and myopia is prepared through adding the solution of carotenoid extracted from microalgae (500-600 ppm) to deionized water (60-100 times of the said PVP), stirring to obtain the solution of carotenoid, and controlling the concentration of carotenoid in the eye solution to be less than 100ppm.

Further, adding sodium hyaluronate, chinese medicinal extract and polyethylene glycol, and stirring to obtain eye drop solution with sodium hyaluronate concentration of 0.01-100ppm; the dosage of the traditional Chinese medicine extract in the eye drops is 1-10%; the polyethylene glycol accounts for 0.01 to 1.5 percent of the total weight.

Furthermore, in the eye drops, the concentration of the microalgae extract carotenoid, phycocyanin ester, chlorophyll ester and glyceric acid lipid in the eye drops is 0.01ppm-100ppm, and the microalgae oil-soluble extract is added with PVP, a water-soluble extract and deionized water to prepare the eye drop microalgae extract. The microalgae extract is prepared from carotenoid, phycocyanin, chlorophyll ester or glycerate or synthetic carotenoid, chlorophyll ester, phycocyanin ester, glycerate water diffusion type dry powder and deionized water, wherein the content of active substances in the carotenoid, chlorophyll ester, phycocyanin ester and glycerate water diffusion type dry powder is 1-20%, and the concentration of the active substances in eye drops is 0.01-100ppm.

A medicine for preventing and treating cataract and myopia and a preparation method thereof,

the method is characterized by comprising the following steps:

(1) soaking the medicinal materials, wherein the medicinal materials with the following components and weight ratio are soaked by 1500-3000 parts of water by weight:

1 to 20 parts of ligusticum chuanxiong hort, 10 to 20 parts of common andrographis herb, 6 to 15 parts of large flower cactus, 6 to 15 parts of liquorice, 10 to 20 parts of dwarf lilyturf tuber, 6 to 15 parts of purslane, 6 to 15 parts of selaginella tamariscina, 1 to 20 parts of hot pepper, 1 to 20 parts of eucalyptus leaf, 1 to 20 parts of kava pepper and 0.1 to 3 parts of borneol; (2) vacuum distilling the above materials with a distilling device at vacuum degree of-0.2 MPA and distillation temperature of 60-80 deg.C to obtain white distilled extract; (3) adding 3-9 parts of humectant, 1 part of each of polyethylene glycol 400 and sodium hyaluronate 1000, and 1 part of microalgae carotene solution into the white distilled extract to obtain the eye drop. (4) Preparing water-soluble and oil-soluble microalgae extract, dissolving 2 parts of microalgae powder in 1000 parts of 95% alcohol, distilling at 50 ℃, vacuum pressure of-0.2 MPA, adding PVP aqueous solution into the distilled liquid, and the content of PVP is 30%; continuously heating the microalgae mixed solution added with PVP in vacuum for 30 minutes at the vacuum degree of-0.2 MPA and the temperature of 50 ℃, removing the organic solvent alcohol to obtain microalgae oil and water extract mixed solution, and measuring the content for later use. The eye drop is prepared by mixing the extracts of Chinese medicinal materials after measuring the contents of carotenoid, phycocyanin and chlorophyll ester, and bottling. (5) The microalgae extract water-soluble solution can also be prepared by mixing water-soluble diffusion dry powder of carotenoid, chlorophyll ester, phycocyanin ester and glyceric acid ester with deionized water; mixing with the prepared Chinese medicinal extract to make into eye drop.

The microalgae comprise: dunaliella, chlorella, haematococcus pluvialis, and Spirulina. These microalgae contain a large amount of oil-soluble antioxidants including carotenoids, phycocyanins, chlorophyll esters.

Dunaliella salina (Dunaliella salina), also known as "Dunaliella salina". Chlorophyceae, dunaliella family. One kind of salt tolerant unicellular eukaryon green algae. The alga body has no cell wall, large variation of body shape, pear shape, ellipse shape and the like, has two flagella with equal length and has a cup-shaped chromoplast in the body. Longitudinal fission or gametophy reproduction. Growing in seawater. Is rich in carotenoid. The glycerol or carotenoid can be extracted from the culture medium by artificial culture. And can be used as bait for fish, shrimp, shellfish, etc. Dunaliella salina is a unicellular eukaryotic alga which exists in a high-concentration salt lake and belongs to plankton. The vitamin C is the unique peculiar life which is discovered at present and can survive in high-concentration saline, is rich in various natural carotenoids, folic acid, vitamin A, vitamin E, linolenic acid, linoleic acid, lecithin, fucoidin, dietary fiber and the like which are required by human health, more than 70 mineral substances and trace elements which are required by human body such as calcium, iron, zinc, selenium and the like, and is also rich in 18 amino acids, wherein 8 amino acids are necessary for human body. Because the cell culture medium is rich in unique and abundant vital elements, the cell culture medium is praised as a cell power source and a life protective agent by the world scientific community.

Chlorella (Chlorella) is a kind of unicellular green algae of genus Chlorella of phylum Chlorophytum, and is a kind of spherical unicellular fresh water algae, the diameter is 3-8 microns, it is one of the earliest life on the earth, it appears 20 hundred million years ago, it is a kind of high-efficient photosynthetic plant, grow and reproduce by photoautotrophy, the distribution is extremely wide. Chlorella glycoprotein has antioxidant effect, and can scavenge free radicals in vivo. Free radicals are intermediate products of biochemical reactions in human life activities, and include superoxide anion free radical (O2 ·) and hydroxyl radical (· OH), among others.

Haematococcus is a kind of freshwater unicellular green algae belonging to Chlorophyta, volvocales, haematococcus and Haematococcus. The algae can accumulate a large amount of astaxanthin to show red color, so it is called Haematococcus pluvialis, also called Haematococcus pluvialis. Haematococcus is an algae food which is discovered in the scientific community at present and is rich in nutritional value and medicinal value after spirulina and chlorella vulgaris are processed. Astaxanthin is a red pigment which imparts a pink color to salmon, shrimp and flamingo. Its chemical structure is similar to that of beta-carotene (present in carrots) and vitamin a. Astaxanthin is part of the group of carotenoids. Natural astaxanthin is able to penetrate the three major human barriers blood-brain barrier, blood-pancreas barrier, blood-testis barrier and is the only carotenoid able to penetrate the blood-brain barrier and is therefore the only carotenoid likely to act on brain cells and the retina of the eye.

Spirulina (scientific name: spirulina) belongs to Cyanophyta, cyanophyceae, oscillatoriaceae, and Spirulina, is an ancient low-grade prokaryotic unicellular or multicellular aquatic plant, and has a length of 200-500 μm and a width of 5-10 μm. [1] Shaped like a clock spring, is spirally blue-green and is also called blue-green algae. The spirulina is rich in high-quality protein, fatty acid of gamma-linolenic acid, carotenoid, phycocyanin, vitamins, and various trace elements such as iron, iodine, selenium, zinc, etc.

Chuan Xiong is used for promoting blood circulation and moving qi, dispelling wind and relieving pain, and Chuan Xiong is warm, fragrant and dry, and can disperse and ascend to the vertex. Also enters blood system and descends to blood sea. Promoting blood circulation and removing blood stasis, it is suitable for various diseases due to blood stasis. Chuan Xiong can move qi and relieve depression, dispel wind-dryness and dampness, activate blood and alleviate pain. It is indicated for wind-cold headache, dizziness, hypochondriac pain, abdominal pain, cold arthralgia, spasm of tendons, amenorrhea, dystocia, postpartum pain due to blood stasis, carbuncle, cellulitis, sore and ulcer. Can be used for treating menoxenia, amenorrhea, dysmenorrhea, abdominal pain, pricking pain in chest and hypochondrium, traumatic injury, swelling and pain, headache, and rheumatalgia. Can be used for treating menoxenia, dysmenorrhea, amenorrhea, dystocia, lochiorrhea, puerperal lochiorrhea, abdominal pain, lump, chest and hypochondrium pain, traumatic injury, swelling and pain, headache, dizziness, dim eyesight, arthralgia due to wind-cold-dampness, numbness of limbs, superficial infection, and pyocutaneous disease.

The common andrographis herb is also known as: firstly, the raw materials are haplolic, the scabrous elephantfoot herb and the elegans, and the nature, taste and channel tropism are as follows: bitter taste and cold nature: it enters lung, heart, large intestine and bladder meridians. Lung heat and lung fire can be used.

Andrographis paniculata Nees has effects of clearing away heat and toxic materials, eliminating dampness and relieving swelling, and is good at treating swelling and pain of throat, cough and asthma, purulent phlegm, etc. caused by lung heat and lung fire. It can also be used for treating eczema and snake and insect bite. According to the records of Lingnan herbal medicine collection, andrographis paniculata Nees can relieve snake venom and treat internal injury and cough. According to records in Quanzhou materia Medica, creat clears away heat and toxic material, diminishes inflammation and subsides swelling, and treats inflammation of throat, dysentery and hyperpyrexia. Effective in clearing away heat and toxic material, eliminating dampness and relieving swelling. The main indications 1, the medicine is used for treating wind-heat common cold, the onset of pestilence, cough due to lung heat (including upper respiratory tract infection, pneumonia, bronchitis and the like), sore throat and the like. 2. Can be used for treating damp-heat dysentery, eczema pruritus, stranguria due to heat, and odynuria. 3. It can be used for treating carbuncle, swelling, sore, snake and insect bite.

The Opuntia ficus-indica, also known as Longtou, overlord, shenxian palm and Guanyin thorn. Can resist strong illumination, extremely dry and resist day and night temperature difference, and has a long medicinal history in China. The record of Ben Cao gang mu Shi Yi: cactus is bland in taste and cold in nature, and has the functions of promoting qi and blood circulation, relieving pain and swelling, and clearing away heat and toxic materials. In folk, people often use cactus to treat parotitis, mastitis, furuncle, pyogenic infections, burns and scalds, cold injuries, tinea manuum, acne and other diseases. Modern medical research finds that the cactus has the effects of clearing heat, removing toxicity, inhibiting bacteria, resisting inflammation and the like. The fleshy stem of cactus contains rich protein, mineral, cellulose, vitamin C, etc., and also contains rich SOD, flavone, polysaccharide, etc. Specifically, the chemical composition of the cactus stem is: the fresh product contains 85-90% of water, 5-12% of crude protein, 62-76% of digestible dry matter and 2-6% of carbohydrate. The cactus fruit contains high glucose and fructose with a content of 6-8% (dry mass) and low protein content of 3.2-5% (dry mass), and is rich in mineral substances such as potassium, calcium, phosphorus, iron, magnesium and the like and Vc, the cactus introduction is promoted as a variety for vegetables at the beginning of edible cactus introduction, and a series of processed food and beverage such as cactus jam, preserved fruits, cans, beer, yoghourt and the like are developed on the basis. Meanwhile, the cactus has the health-care effects of clearing away heat and toxic materials, expelling toxin, promoting granulation, promoting qi and blood circulation, reducing blood sugar, regulating blood fat and the like, and can promote metabolism and improve human immunity after being taken for a long time. A large number of researches show that cactus has curative effects on various diseases and is widely used for clinically treating stomachache, dysentery, hemorrhoidal bleeding, cough, diabetes and the like in China.

Radix Glycyrrhizae is also named as Mel, radix Glycyrrhizae, GUOLAO, MEICAO, HEIGEN, LINGTONG, herba Hyssopus officinalis, radix Stephaniae Japonicae, radix Glycyrrhizae, and radix Glycyrrhizae Pratentis. It is neutral in nature and flavor, mild in nature and sweet in taste. They enter heart, stomach, spleen and lung meridians. Has the effects of invigorating spleen, replenishing qi, relieving cough, eliminating phlegm, relieving spasm, relieving pain, and regulating drug properties. They belong to qi tonics classified under deficiency tonics. Clinical application, oral administration: decocting 2-6 g in water, small in dosage for harmonizing the effect, slightly larger in dosage as main drug, and about 10 g in dosage; 30-60 g can be used for rescuing poisoning. Stir-baked for tonifying herbs and unprocessed for clearing and purging herbs. External application: proper amount, decocting, washing and soaking; or by grinding and applying. Treating spleen and stomach weakness, deficiency of middle-warmer energy, cough, asthma, carbuncle, sore, abdominal spasm, pain, relieving drug toxicity, and removing drug toxicity. Unprocessed for clearing heat, and stir-baked for tonifying middle energizer. It is contraindicated for excess syndrome with abdominal distention. Pharmacological research shows that the liquorice has the functions of adrenocortical hormone, anti-inflammation, anti-ulcer, anti-allergic reaction, anti-cancer, anti-bacteria, anti-virus, promoting pancreatic secretion, inhibiting in vitro intestines, regulating immune function, relieving cough, eliminating phlegm, resisting mutation, detoxifying, resisting oxidation, protecting the functions of the ear and the vestibule, promoting urination, protecting the liver, preventing arteriosclerosis, resisting cerebral ischemia, preventing diabetic complications and the like. The chemical components of the product mainly comprise liquiritin, glycyrrhizic acid, glycyrrhizin, syringene oxide, glycyrrhetin, 18 alpha-hydroxy glycyrrhetinic acid, isoglycyrrhetinic acid, glycyrrhetinic essence, formononetin, neolicochalcone D, glabrene aglycone, isolicoflavonol, triterpenoid saponin, coumarin and the like.

Radix Ophiopogonis, ophiopogon japonicus, radix Stephaniae Tetrandrae, and Limonitum. It is slightly cold in nature, sweet and slightly bitter in taste. They enter heart, lung and stomach meridians. Has the effects of nourishing yin, promoting the production of body fluid, moistening lung and clearing away heart-fire. They belong to yin tonics classified under deficiency tonics. Pharmacological research, which has the function of protecting the cardiovascular system; enhancing hypoxia tolerance and prolonging the survival time of hypoxia under normal pressure; enhancing immune function; reducing blood sugar; delaying aging; inhibiting gastrointestinal propulsion; and (4) resisting bacteria. The radix ophiopogonis is a good medicine for nourishing yin and moistening lung, and has a good effect of reducing blood sugar in recent years; in clinical application, the heart strengthening effect is stable and good. Experiments also prove that the water-soluble polysaccharide in the dwarf lilyturf tuber has the functions of resisting anoxia and promoting immunity. Chemical components containing multiple steroid saponins, wherein the ophiopogonin A has the highest content, and the ophiopogonin B has the highest content; in addition, it contains many homoisoflavonoids. 5 flavonoid compounds are also separated and identified from the Zhejiang dwarf lilyturf tuber. In addition, it also contains ophiopogonone A, ruscogenin, diosgenin, ophiopogonflavanone, alpha-patchoulene, ethyl palmitate, oleanolic acid, etc. Herba Portulacae is also called as melon seed, sour and herba Otteliae Alismoidis. The nature, flavor and meridian tropism, the taste is sour and the nature is cold. It enters large intestine meridian and liver meridian. Has the functions of clearing away heat and toxic material, cooling blood and stopping bleeding. Belongs to heat-clearing herbs and heat-clearing and toxicity-removing herbs. The clinical application dosage is 9 to 15 grams, and the decoction is taken; the dosage of the fresh product is 30-60 g. Proper amount of the powder is pounded and applied to the affected part. It can be used for treating enteritis, bacillary dysentery, furuncle, toxic swelling, snake and insect bite, hemorrhoid with swelling and pain, eczema, erysipelas, snake and insect bite, hematochezia, hemorrhoid with blood, metrorrhagia, acute dermatitis, subacute dermatitis, herpes zoster, puerperal hemorrhage, functional facial hemorrhage, appendicitis, and ancylostomiasis. Pharmacological research, which has the effect of uterine contraction; affect the cardiovascular and respiratory systems; the Chinese medicinal decoction has biphasic action on skeletal muscle, so that the contraction tension, amplitude and frequency of small intestine are increased, but the decoction is also reported to have an inhibiting effect on guinea pig isolated small intestine; the antibacterial effect is achieved; has cholesterol lowering effect. Can promote the normalization of epithelial cell function and the healing of ulcer. Has diuretic effect. The alcohol extract or the water decoction has obvious inhibition effect on various dysentery bacilli; the composition also has an inhibiting effect on pathogenic dermatophytes such as escherichia coli, typhoid bacillus, staphylococcus aureus, dorsalis parvum and the like, and can generate drug resistance on dysentery bacillus; it also has the effects of promoting ulcer healing, contracting blood vessel, and regulating blood lipid. The chemical components mainly comprise vitamins, organic acids, amino acids, saccharides, fatty acids, flavonoids, trace elements, mucoid, alanine, betanin, isobetanin, norepinephrine and the like.

Selaginella tamariscina, another name is: one grab, tiger paw, perennial grass, ten thousand years pine, etc. Pungent and mild in nature and flavor. The book Jing: "pungent flavor, warm. "2" other records: "sweet, mild and cold, and non-toxic. "3" materia Medica of this materia Medica: unprocessed, pungent and neutral; moxibustion is pungent and warm. "4" Guangxi Zhi Zhong Yao Zhi (TCM journal in Guangxi): "bland and slightly astringent taste, slightly cold in nature. "entering the meridian" in Ben Cao Jing Shu "(Ben Cao Jing Shu): "enter the blood system of foot jueyin and shaoyin. "function, unprocessed is breaking blood, stir-baked to stop bleeding. For indications, the raw one is used for amenorrhea, abdominal mass, traumatic injury, abdominal pain and asthma; stir-baked into charcoal is indicated for hematemesis, hemafecia, hematuria and rectocele. 1. For abdominal pain, amenorrhea and obstruction in the abdomen, it is indicated for blood stasis, pain and pain due to blood stasis, pungent and warm flavor of Selaginella tamariscina, mild and warm nature, and pungent and warm nature. 2. For blood-stasis syndrome, it is pungent and warm with pungent and warm natured herbs, and can dispel stasis and alleviate pain, so it is indicated for hematemesis, hemafecia, hematuria, traumatic injuries and metrorrhagia and metrostaxis. 3. For relieving cough and resolving phlegm, it is pungent and slightly warm in flavor, it is the lung meridian at the upper part, warms lung to dispel cold, relieves cough and resolves phlegm. Pathogenic wind-cold attacking the lung, lung qi failing to disperse and fluids failing to distribute, manifested as cough, expectoration, thin and white sputum, nasal obstruction, clear nasal discharge, itching and heavy throat, headache, fever, aversion to cold, aversion to wind, soreness of joints, thin and white tongue coating, and superficial, tense or slow pulse. For treatment, it is indicated for dispelling wind and cold, dispersing lung qi and nourishing gold, relieving cough and resolving phlegm. It is indicated for its action. 4. Activating meridians and collaterals, as well as activating blood and promoting qi circulation, and dredging meridians and collaterals, selaginella tamariscina Lingzi are good at treating flaccidity. The weak fingers are not used, the weak limbs are not needed, and the frown fingers are weak. For impotence, it is an ancient practice to get yangming, but it is still a blood stasis after a long period of treatment, failing to nourish the collaterals, numbness, and even withering of the tendons and vessels. The administration of qi-moving and blood-activating herbs can bring new and old feeling. (1) The book Jing: "governing the five zang organs with pathogenic qi, cold-middle energizer heat pain of female yin, abdominal mass, blood block and sterility. "(2) bibliography: "relieving cough and dyspnea", treating rectocele, stranguria and nodulation, wind-dizziness in head, atrophy-flaccidity, strengthening yin and replenishing essence. "(3) treatise on drug Property: "treat menorrhagia. "(4) Rihuazi Ben Cao (Japanese: "Zhen Xin, excepting quite facial complexion, headache wind, warm water and viscera. Unprocessed is used to break blood and stir-baked is used to stop bleeding. "(5) Classification of herb Properties": for traumatic injury, move qi, stir-bake black and stop hematemesis. "(6) modern practical Chinese medicine": "treat hematuria. (7) Anhui medicinal materials: "externally applied can treat knife wound. "(8) Nanning City records of drugs: for heat intestinal hemorrhage and metrorrhagia, it is used externally to heal bone. ", a

Eucalyptus leaves are called Eucalyptus leaves (modern practical traditional Chinese medicine) and Eucalyptus globulus leaves (Guangxi Chinese medicine). Bitter and pungent in flavor and cool in nature. (1) Guangxi Chinese medicine J: bitter taste and warm nature. And (2) in the journal of Sichuan Chinese herbs: "warm in nature, bitter in taste, non-toxic. (3) Yunnan Chinese herbal medicine: bitter, pungent and cool. The Chinese medicinal composition has the main functions of treating cold, influenza, dysentery, enteritis, arthralgia, cystitis, scald, mange, erysipelas, neurodermatitis, eczema and carbuncle sore pyogenic infections.

The capsicum is another name, capsicum, spicy eggplant, spicy tiger, preserved eggplant, capsicum, peppers and big peppers. The nature and flavor enter meridians, heat property and pungent taste. It enters heart and spleen meridians. Has the functions of warming the middle-jiao to dispel cold, stimulating appetite and promoting digestion. It belongs to interior-warming herbs. Pharmacological research shows that the product has analgesic and anti-inflammatory effects. Effects on the digestive system: the hot pepper decoction is drenched to promote the healing of the acute and chronic gastric mucosa injury of the rat caused by hydrochloric acid and acetic acid; oral administration of red dry pepper powder capsule promotes ulcer healing of gastric ulcer patients, and pepper can enhance the contraction movement of guinea pig isolated gallbladder, and its effect can be weakened by indomethacin but not blocked by atropine. Effects on the cardiovascular system: the capsaicin can improve myocardial function of rat reperfusion injury, inhibit creatine kinase release, and increase plasma concentration of calcitonin gene related peptide. Other functions are as follows: capsaicin selectively exhausts neuropeptide substances at the tail end of sensory nerve, reduces sensitivity to chemical substances, and has desensitization effect on nasal mucosa of human and animals. Capsaicin treats the unilateral nasal mucosa of a guinea pig, reduces ipsilateral secretion, completely blocks contralateral secretion reaction, has the functions of eliminating axonal reaction and nasal secretion caused by central reflex, and reduces the sensitivity of sensory nerves to noxious stimulation. Chemical components, wherein the pepper fruit contains capsaicin components, also contains various low-boiling point and high-boiling point volatile carboxyls, and also contains beta-carotene, lutein, zeaxanthin, capsorubin, cordierite, solanine, solanidine, citric acid, tartaric acid, malic acid and the like, and the seed contains solanine, solanidine, 4-alpha-methyl-5-alpha-cholest-8-ene-3-beta-ol cycloartenol, 24-methylene cycloartenol, lupeol and the like.

The main effective components of kava pepper are Kavalactones (Kavalactones), methysticin, kawain (Kawain), etc., can bidirectionally regulate neurotransmitter, has various effects of resisting anxiety and depression, tranquilizing and hypnotizing, local anesthesia, anticonvulsive, etc., and no drug dependence is observed.

Kava pepper was approved by the german federal health administration for the treatment of anxiety as early as 1990, and was incorporated in the united kingdom as the plant pharmacopoeia, the united states as the new edition of the united states pharmacopoeia, and many countries in the united states of europe and america as over-the-counter or prescription drugs. Dihydrokavain and dihydrokavain contained in kava (PipermethoccumFost) have remarkable muscle relaxation effect, and their analgesic effect is superior to aspirin.

Because kava root has natural active substances, the kava root can act on the emotional center of the brain to exert the physiological effect, relax the mind and body, and reduce the pressure, relieve the anxiety, correct the depression and promote the sleep by drinking kava wine, thereby becoming the mental health-care folk prescription of modern people.

In recent years, kava is recommended worldwide as a food supplement. Piper methysticum has been one of the best 20 herbs sold in Germany in 1995. And is also one of the 16 best-selling herbals in the United states. The Kava (Kava, kawx) is popular among folk doctors in the island of south Pacific ocean and is regarded as the "holy medicine", and indigenous residents regard the Kava as the "highest-ranking plant". Hawaii once stipulates that the people steal slips to make death criminals, and is sufficient to see how the plant is important.

From the 19 th century, european and American scientists have proved from chemical, pharmacological, toxicological and clinical studies that kava mainly comprises kavalactone, methysticin, kawain, dihydrokawain and the like, can bidirectionally regulate neurotransmitters, relieve stress, relieve anxiety, overcome depression, relax muscles, eliminate fatigue and relieve insomnia, and has unexpected effects. Slips are then collected in the plant pharmacopoeia, the united states new edition, the united states pharmacopoeia, and many countries in the united states of europe and america classify slips as over-the-counter or prescription drugs.

Kava was approved by the Food and Drug Administration (FDA) as a mental health food in 1992, and the advent of kava in france made the conventional hypnotic almost unquestionable. Kava is used as a health product for relieving mental stress, stabilizing mental balance, and improving sleep in Japan. As early as 1995, american scientists karse and professor mallow presented in coworking "first health" and "natural answers to slips, stress, anxiety and insomnia": imbalance of neurotransmitter is the root of insomnia, and the kava, an herbal medicine capable of regulating neurotransmitter, is a natural answer for solving insomnia problems such as stress, anxiety, depression and the like and psychological problems.

Borneol is a medicine for inducing resuscitation and refreshing mind, clearing heat and relieving pain, belonging to the field of resuscitation drugs.

Preferably, the water in the step (1) is added in an amount of 1500 to 3000 parts by weight, and the water is deionized water, purified water or distilled water.

Preferably, the medicinal materials in the step (1) are soaked in water according to the following components in parts by weight:

15 parts of common andrographis herb, 15 parts of szechuan lovage rhizome, 15 parts of large flower cactus, 15 parts of selaginella tamariscina, 15 parts of liquorice, 15 parts of purslane, 9 parts of kava pepper, 9 parts of eucalyptus leaf, 15 parts of dwarf lilyturf tuber, 1 part of hot pepper and 2 parts of borneol.

Preferably, the soaking time in the step (1) is 30 to 60 minutes.

Preferably, the distillation device in step (2) is a vacuum distillation generator made of stainless steel, enamel or glass.

Preferably, the distillation time in step (2) is 30 to 60 minutes.

Preferably, in the step (3), the humectant is at least one of butanediol, glycerol, polyalcohol or propylene glycol; the small molecule moisturizing lubricant is polyethylene glycol 400 and sodium hyaluronate 1000.

Preferably, in the step (3), the amount of the humectant is 0.5 to 1.5% by weight based on the weight of the distilled extract.

Preferably, the extracting solution of the microalgae in the step (4) is respectively extracted by alcohol and aqueous solution, and the alcohol is distilled off; the mixed solution of the residual microalgae oil-soluble extract and microalgae water-soluble extract is used for the eye drop.

Compared with the prior art, the invention has the advantages that: the microalgae oil-soluble extract is used as an antioxidant for resisting free radicals, macromolecular peroxide is directly combined with parts such as retina, cornea, ciliary muscle and the like, the microalgae water-soluble extract is matched with traditional Chinese medicines, common andrographis herb, ligusticum wallichii, opuntia ficus-indica and selaginella tamariscina are used as monarch medicines, and liquorice, purslane and radix ophiopogonis are used as minister medicines, kava pepper, eucalyptus leaves, hot pepper and borneol as assistants and guides. Because the common andrographis herb has the effects of clearing heat and removing toxicity and dissipating carbuncle swelling, the combination of the common ligusticum, the large flower cactus and the selaginella tamariscina can enhance the effects of clearing liver and improving vision and dissipating the carbuncle swelling, eleven medicaments of monarch, minister, assistant and guide are matched and applied together, the effects are strong, the common andrographis herb is distilled into dew and good in absorption, and the volatilization speed is slowed down by adding a moisturizing agent. Has no side effect, has effects of clearing heat, removing pathogenic fire, removing toxic substance, relieving inflammation, improving eyesight, removing nebula, promoting blood circulation and removing blood stasis, and is suitable for preventing and treating myopia, astigmatism, cataract, glaucoma, keratitis, conjunctivitis, asthenopia, epiphora induced by wind, etc. Has the characteristics of rapid inflammation diminishing, fire removing and instant fatigue eliminating. The practical application proves that the obtained eye drop has good effects on treating myopia, cataract, muscae volitantes, epiphora induced by wind, asthenopia and glaucoma.

Detailed Description

The present invention is described in further detail below with reference to examples.

Example 1, 1800 parts of distilled water (or deionized water) obtained by distillation is used for soaking medicinal materials for 40 minutes, then a stainless steel steam generator is used for low-temperature distillation, the temperature is controlled to be 60-80 ℃, after the temperature of steam reaches 60 ℃, the vacuum degree is-0.2 MPA, distillation is carried out for 40 minutes, the obtained white liquid is pure dew, the pure dew is fast to absorb and volatilize, after cooling, 3 parts of medical glycerin and a small molecule moisturizing lubricant are added, namely polyethylene glycol 400 and sodium hyaluronate 1000 are respectively used for moisturizing, and the medical glycerin is adopted as the best, so that the speed of volatilization is reduced, and the efficacy is enhanced. The weight ratio of the medicinal materials is as follows: 15 parts of common andrographis herb, 15 parts of szechuan lovage rhizome, 15 parts of large flower cactus, 15 parts of selaginella tamariscina, 15 parts of liquorice, 15 parts of purslane, 9 parts of kava pepper, 9 parts of eucalyptus leaf, 15 parts of dwarf lilyturf tuber, 1 part of hot pepper and 2 parts of borneol.

Preparing water-soluble and oil-soluble extracts of dunaliella salina, dissolving 2 parts of dunaliella salina powder by 1000 parts of 95% alcohol, distilling at 50 ℃, extracting for 50 minutes at a vacuum degree of-0.2 MPA, and adding PVP water solution into the liquid after alcohol distillation, wherein the content of PVP is 30%; continuously heating the saline algae mixed solution with PVP in vacuum for 30 min at 50 deg.C to obtain saline algae oil-soluble and water-soluble extraction mixed solution, and measuring carotenoid content for use.

Mixing the above traditional Chinese medicine distilled mixed solution added with humectant with oil soluble extract and water soluble extract of Dunaliella salina, and making into eye drop.

Example 2, 1800 parts of distilled water obtained by distillation is used for soaking medicinal materials for 40 minutes, then distilled at low temperature by using a stainless steel steam generator, the temperature is controlled to be 60-80 ℃, the vacuum degree is-0.2 MPA after the temperature of steam reaches 60 ℃, and the white liquid obtained by distillation is pure dew, because the pure dew is fast to absorb and volatilize, after cooling, 3 parts of medical glycerin and a micromolecule moisturizing lubricant are added, namely polyethylene glycol 400 and sodium hyaluronate 1000 respectively for moisturizing, and the medical glycerin is adopted as the best, so that the volatilization is reduced, and the efficacy is enhanced. The weight ratio of the medicinal materials is as follows: 15 parts of common andrographis herb, 15 parts of szechuan lovage rhizome, 15 parts of large flower cactus, 15 parts of selaginella tamariscina, 15 parts of liquorice, 15 parts of purslane, 9 parts of kava pepper, 9 parts of eucalyptus leaf, 15 parts of dwarf lilyturf tuber, 1 part of hot pepper and 2 parts of borneol.

A water-diffusible dry powder of carotenoid (synthetic) is a technological process mode, which is a technology that the carotenoid (synthetic) is added with emulsifier modified starch and the like to make fat-soluble carotenoid (synthetic) to be diffused in water, the content of carotenoid (synthetic) in the water-diffusible dry powder of carotenoid (synthetic) is 1% -20% of the carotenoid (synthetic) content, and the concentration of carotenoid (synthetic) in the eye drops is 0.01-100ppm.

Mixing the above traditional Chinese medicine distilled mixed solution added with humectant with water-dispersible carotenoid (synthetic type) dry powder (synthetic type commercially available, non-microalgae extract) deionized water solution, and making into eye drop.

Example 3, 1800 parts of distilled water obtained by distillation is used for soaking medicinal materials for 40 minutes, then a stainless steel steam generator is used for low-temperature distillation, the temperature is controlled to be 60-80 ℃, the vacuum degree is-0.2 MPA after the temperature of steam reaches 60 ℃, the distillation lasts 40 minutes, the obtained white liquid is hydrolat, because the hydrolat is fast to absorb and volatilize, after cooling, 3 parts of medical glycerin and a micromolecular moisturizing lubricant are added, namely polyethylene glycol 400 and 1000 parts of sodium hyaluronate are respectively used for moisturizing, and the medical glycerin is adopted as the best, so that the volatilization is reduced, and the efficacy is enhanced. The weight ratio of the medicinal materials is as follows: 15 parts of common andrographis herb, 15 parts of szechuan lovage rhizome, 15 parts of large flower cactus, 15 parts of selaginella tamariscina, 15 parts of liquorice, 15 parts of purslane, 9 parts of kava pepper, 9 parts of eucalyptus leaf, 15 parts of dwarf lilyturf tuber, 1 part of hot pepper and 2 parts of borneol. Preparing oil and water extracts of chlorella, dissolving 2 parts of chlorella powder in 1000 parts of 95% alcohol, distilling at 50 ℃, extracting for 50 minutes at a vacuum degree of-0.2 MPA, adding PVP (polyvinyl pyrrolidone) water solution into the liquid after alcohol distillation, continuously heating chlorella mixed solution added with PVP at 20% in vacuum for 30 minutes at 50 ℃; measuring the content for later use. The concentration in the eye drops is 0.01-100ppm; carotenoid content of 1-10%, and carotenoid concentration in eye drops of 0.01-100ppm.

Adding the above traditional Chinese medicine distilled mixed solution added with humectant, oil soluble extract of Chlorella vulgaris and water soluble extract mixed solution into deionized water solution, mixing, and making into eye drop.

Example 4, 1800 parts of distilled water obtained by distillation is used for soaking medicinal materials for 40 minutes, then distilled at a low temperature by using a stainless steel steam hair generator, the temperature is controlled to be 60-80 ℃, the vacuum degree is-0.2 MPA after the temperature of steam reaches 60 ℃, and the white liquid obtained by distillation is pure dew, because the pure dew is fast to absorb and volatilize, after cooling, 3 parts of medical glycerin and a micromolecule moisturizing lubricant are added, namely polyethylene glycol 400 and sodium hyaluronate 1000 are respectively used for moisturizing, and the medical glycerin is used as the best, so that the volatilization is reduced, and the efficacy is enhanced. The weight ratio of the medicinal materials is as follows: 15 parts of common andrographis herb, 15 parts of szechuan lovage rhizome, 15 parts of large flower cactus, 15 parts of selaginella tamariscina, 15 parts of liquorice, 15 parts of purslane, 9 parts of kava pepper, 9 parts of eucalyptus leaf, 15 parts of dwarf lilyturf tuber, 1 part of hot pepper and 2 parts of borneol. Preparing a water-soluble and oil-soluble extract of haematococcus pluvialis, dissolving 2 parts of haematococcus pluvialis powder by using 1000 parts of 95% alcohol, distilling at 50 ℃, extracting for 50 minutes at a vacuum degree of-0.2 MPA, adding a PVP (polyvinyl pyrrolidone) aqueous solution into the liquid after alcohol distillation, wherein the PVP content is 10%, and continuously heating the mixed solution of the haematococcus pluvialis added with PVP for 30 minutes in vacuum at 50 ℃; measuring the content for later use. The concentration in the eye drops is 0.01-100ppm; 1-10% carotenoid, and the concentration of carotenoid in the eye drop is 0.01-100ppm.

Adding the traditional Chinese medicine distillation mixed liquor added with the humectant and the mixed liquor of the haematococcus pluvialis oil-soluble extract and the water-soluble extract into deionized water solution for mixing, and preparing the special eye drop.

Example 5, 1800 parts of distilled water obtained by distillation is used for soaking medicinal materials for 40 minutes, then distilled at low temperature by using a stainless steel steam generator, the temperature is controlled to be 60-80 ℃, the vacuum degree is-0.2 MPA after the temperature of steam reaches 60 ℃, and the white liquid obtained by distillation is pure dew, because the pure dew is fast to absorb and volatilize, after cooling, 3 parts of medical glycerin and a micromolecule moisturizing lubricant are added, namely polyethylene glycol 400 and sodium hyaluronate 1000 are respectively used for moisturizing, and the medical glycerin is adopted as the best, so that the volatilization is reduced, and the efficacy is enhanced. The weight ratio of the medicinal materials is as follows: 15 parts of common andrographis herb, 15 parts of szechuan lovage rhizome, 15 parts of large flower cactus, 15 parts of selaginella tamariscina, 15 parts of liquorice, 15 parts of purslane, 9 parts of kava pepper, 9 parts of eucalyptus leaf, 15 parts of dwarf lilyturf tuber, 1 part of hot pepper and 2 parts of borneol. Preparing oil-soluble and water-soluble spirulina extract, dissolving 2 parts of spirulina powder in 1000 parts of 95% alcohol, distilling at 50 ℃, with a vacuum degree of-0.2 MPA, extracting for 30 minutes, adding PVP water solution into the liquid after alcohol distillation, with a PVP content of 40%, and continuously heating the spirulina mixed liquid added with PVP in vacuum for 30 minutes at 50 ℃; measuring the carotenoid content for later use. The concentration in the eye drops is 0.01-100ppm; the content of carotenoid, phycocyanin and chlorophyll ester is 1% -10%, and the concentration of carotenoid, phycocyanin and chlorophyll ester in the eye drops is 0.01-100ppm. Adding the above traditional Chinese medicine distilled mixed solution added with humectant and mixed solution of oil-soluble and water-soluble extract of Spirulina into deionized water solution, mixing, and making into eye drop.

In order to verify the application effect of the invention, the inventor carries out clinical trials in which:

1. 60 pseudomyopia groups are selected for use, and after the pseudomyopia is used for three months, 58 cases of eyes are improved by 0.2 degrees, and 40 cases of eyes are improved by 0.4 degrees or more.

2. After the cataract extraction liquid is used for 60 cataract people, 58 cataract people have obvious improvement after the cataract extraction liquid is used for three months, 59 cataract people with 0.4 degree of binocular elevation, and the rest cataract extraction liquid also has certain improvement effect.

The eyedrops obtained in example 1 are applied to the eyes of a plurality of patients, as follows:

application example 1, zhao lady, people in inner Mongolia Guke stone City, age 76 years old, self-worried that eyes are dry and lacked to see clearly what is unclear, no effect can be seen in eye drops purchased in pharmacy, multiple treatments in hospitals in inner Mongolia Guke stone City are ineffective, right eye cataract is confirmed, left eye astigmatism plus muscae volitantes, the eye drops in the embodiment are adhered to be sprayed for three times every day for 30 days, one bottle of 10ml is basically used up, eyes are bright, lacrimation is not so good, and foreign matters are not existed; the second bottle is continuously used for 30 days, the left eye can clearly see the objects without deformation, dryness and lacrimation, the right eye can clearly see the objects for 30 to 60 minutes, and at present, the second bottle is continuously used for consolidation and is sprayed twice every day. The naked eye vision of the left eye is recovered to 0.8 from 0.3 before use, and the naked eye vision of the right eye is recovered to 0.5 from 0.1.

This example 2 obtains eye drops for application to the eyes of a plurality of patients, as exemplified below

Application example 2, wen somewhere, man, 75 years old, call for inner Mongolia and Haoyeshan. After more than ten years of cataract, the vision of the left eye is reduced to 0.1, and the vision of the right eye is reduced to 0.2; all objects seen from the above are modified, and mosquitoes are also present. Doctors recommend operative treatment, but the inventor decides that conservative treatment does not carry out operative treatment, but does not improve the treatment, the eye drops in the example 2 are used for more than one year, mosquitoes in front of eyes are not basically used, and the eye drops are sprayed every day and are clear, cool and moist. The vision of both eyes is obviously recovered. The left eye vision is restored to 0.3 after three months, the right eye is restored to 0.5, and the television can be watched at night (before the television is listened).

This example 3 provides eye drops for application to the eyes of a plurality of patients, as exemplified below

Application example 3, the Lu women, the Shanxi province of the family, the Chang Zhi City, the chronic keratitis, all the eye drops suitable for the keratitis in the pharmacy are used, the effect is not ideal, the doctor recommends to do the operation, the doctor introduces the spraying of the traditional Chinese medicine eye drops in the embodiment 3, the doctor insists on using the eye drops for nearly one month, feels that the eyes are comfortable, especially the eyesight is improved, feels that the eyes are bright after spraying, the doctor goes to the hospital to see, says that the keratitis is sixty percent better, and the spraying continues for one month every day, so the eyes are better. After three months of examination, the eyes recovered to normal and the naked eye vision improved by 0.4.

This example 4 obtains eye drops for application to the eyes of a plurality of patients, as exemplified below

In application example 4, a certain populus, living in the region of the sunny province of Beijing, anzhenlie, has a common hair disease with tearing against wind, and cataract lasts for 10 years, and the eye drop of example 4 is introduced by friends and is sprayed on the body at any time, so that the eyes feel not tearing against wind, and the eyesight of the eyes is 0.5, which is 0.3 higher than that of the former.

This example 5 provides eye drops for multiple patients, as listed below

Application example 5, a certain plum is a male, 21 years old, and a person in small olive town in Zhongshan city, guangdong province, 14 years old can find myopia, more than 350 degrees, and the glasses are worn, so that the parents feel special care because of no inheritance in the family, and the hospital has checked that no special diseases exist, and recommends to use the eyedrops in the example 5 by people, the person sprays for about five times every day, the massager is used after spraying to massage the eyes for 18 minutes, and then the eyes are sprayed for several times, so that the eyes are particularly comfortable and insist to use, so far, more than half a year is used, the degree of the left eye glasses is reduced to 200 degrees, the degree of the right eye glasses is reduced to 250 degrees, and the person just starts to have little discomfort, and the eyedrops really play a role in treating myopia after being matched with the glasses after going to the hospital for optometry.

Claims

1. A medicine for preventing and treating cataract and myopia and a preparation method thereof are characterized by comprising the following steps:

1 to 20 parts of ligusticum chuanxiong hort, 10 to 20 parts of common andrographis herb, 6 to 15 parts of large flower cactus, 6 to 15 parts of liquorice, 10 to 20 parts of dwarf lilyturf tuber, 6 to 15 parts of purslane, 6 to 15 parts of selaginella tamariscina, 1 to 20 parts of hot pepper, 1 to 20 parts of eucalyptus leaf, 1 to 20 parts of kava pepper and 0.1 to 3 parts of borneol. (2) Vacuum distilling the above materials with a distilling device at 60-80 deg.C to obtain white distilled extract. (3) Adding 3-9 parts of humectant, 1 part of each of polyethylene glycol 400 and sodium hyaluronate 1000 and 1 part of microalgae carotene solution into the white distilled extract to obtain eye drop. (4) Preparing water-soluble and oil-soluble extracts of microalgae, dissolving 2 parts of microalgae powder by 1000 parts of 95% alcohol, distilling at 50 ℃, and adding PVP aqueous solution into the liquid after alcohol distillation, wherein the content of PVP is 10% -50%; and continuously heating the microalgae mixed solution added with PVP in vacuum for 30 minutes at 50 ℃ to obtain microalgae oil-soluble and water-soluble extract mixed solution, and measuring the carotenoid content for later use. The eye drop is prepared by measuring the contents of carotenoid, phycocyanin and chlorophyll ester, blending to below 100ppm, mixing with the extractive solution of Chinese medicinal materials added with humectant, and bottling. (5) The aqueous solution of the microalgae oil-soluble extract can also be prepared by mixing water-soluble diffusion dry powder of synthesized carotenoid, chlorophyll ester, phycocyanin ester and glyceric acid ester and deionized water; mixing the prepared traditional Chinese medicine extract with humectant to prepare the special eye drop.

2. The method according to claim 1, wherein the water in the step (1) is added in an amount of 1500 to 3000 parts by weight, and the water is deionized water, purified water or distilled water.

3. The preparation method according to claim 1, wherein the medicinal materials in the step (1) are prepared by soaking the following components in parts by weight in water: 1 to 20 portions of Szechuan lovage rhizome, 10 to 20 portions of common andrographis herb, 6 to 15 portions of large flower cactus, 6 to 15 portions of liquorice, 10 to 20 portions of dwarf lilyturf tuber, 6 to 15 portions of purslane, 6 to 15 portions of selaginella tamariscina, 1 to 20 portions of hot pepper, 1 to 20 portions of eucalyptus leaf, 1 to 20 portions of kava pepper and 0.1 to 3 portions of borneol.

4. The method according to claim 1, wherein the soaking time in the step (1) is 30 to 60 minutes.

5. The method according to claim 1, wherein the distillation apparatus in step (2) is a vacuum distillation generator made of stainless steel, enamel or glass.

6. The production method according to claim 1, wherein the distillation time in the step (2) is 30 to 60 minutes.

7. The method according to claim 1, wherein the humectant in the step (3) is at least one of butylene glycol, glycerin, polyhydric alcohol, or propylene glycol; the small-molecule moisturizing lubricant is polyethylene glycol 400 and sodium hyaluronate 1000.

8. The method according to claim 1, wherein the humectant is added in an amount of 0.5 to 1.5% by weight based on the weight of the distilled extract in the step (3).

9. The method according to claim 1, wherein the microalgae extract in step (4) is: mixing oil-soluble extract of microalgae with water-soluble extract of microalgae, wherein the solvent used in the oil-soluble extract is alcohol (or other organic solvent), and the extract is carotenoid, phycocyanin ester, chlorophyll ester, and glycerate; the extraction time is vacuum heating for 30 minutes, the temperature is 50 ℃, and the vacuum degree is-2 MPA; the microalgae comprise: dunaliella salina, chlorella vulgaris, haematococcus pluvialis, and Spirulina, wherein the microalgae contains large amount of oil soluble antioxidant including carotenoid, phycocyanin, chlorophyll ester, and glycerol oleate; similar synthetics of these microalgae antioxidants are also possible.

10. The method according to claim 1, wherein the mixed solution of the water-soluble solution of the oil-soluble extract of microalgae in step (5) is further prepared by mixing water-soluble diffusion dry powder of synthesized carotenoid, chlorophyll ester, phycocyanin ester, and glyceric acid ester with deionized water; the eye drop is prepared by matching the prepared traditional Chinese medicine extract.