CN1154246A - Recipe of antibacterial and antiviral drug - Google Patents

Recipe of antibacterial and antiviral drug Download PDF

Info

Publication number
CN1154246A
CN1154246A CN 96100031 CN96100031A CN1154246A CN 1154246 A CN1154246 A CN 1154246A CN 96100031 CN96100031 CN 96100031 CN 96100031 A CN96100031 A CN 96100031A CN 1154246 A CN1154246 A CN 1154246A
Authority
CN
China
Prior art keywords
purity
antibacterial
scutellaria baicalensis
forsythia
antiviral drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN 96100031
Other languages
Chinese (zh)
Inventor
李宏
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN 96100031 priority Critical patent/CN1154246A/en
Priority to CN 97191640 priority patent/CN1069545C/en
Priority to PCT/CN1997/000001 priority patent/WO1997025054A1/en
Priority to AU13644/97A priority patent/AU1364497A/en
Publication of CN1154246A publication Critical patent/CN1154246A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634—Forsythia

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)

Abstract

A kind of antibacteria, antivirus medicine is prepd, from Scutellaria baicalensis (root of large-flowered skullcap), honey suckle flower bud and Forsythia suspensa (capsule of weeping forsythia). Scutellaria baicalensis total glucoside, honey suckle bud total organic acid and Forsythia suspensa ester glucoside are extracted from them and refined into effetive part or effective monomer, then formulated according to definite proportion into solid or liquid or aseptic medical prepn. or cosmetics. This invented medical composition possesses of the advantages of high purity, low dose, good therapeutic effect and low irritant.

Description

A kind of prescription of antibacterial and antiviral drug
The present invention is a kind of prescription of antibacterial and antiviral drug.
The invention belongs to field of medicine producing technology.
Existing pharmaceutical preparation, majority is that impurity is many, dosage is big, purity is low with the crude preparation by using of traditional method preparation, and the many bioavailability of peroral dosage form impurity are low, the many zests of injection type are big, as existing 'Shuang Hualian ' (being made up of Radix Scutellariae, Flos Lonicerae, Fructus Forsythiae).Feature of the present invention is to extract Radix Scutellariae general glycoside, Flos Lonicerae total organic acids, forsythoside and other active component respectively from scutellariae,radix, Flos Lonicerae alabastrum, Fructus Forsythiae and other position or other kindred plant, be refined into effective site or effective monomer respectively, improve purity to reach, reduce dosage, improve curative effect, reduce the purpose of zest.
Modern study proves that all baicalin, chlorogenic acid, forsythoside all have stronger antibiosis and antiviral functions, but antimicrobial spectrum all has certain limitation, three kinds of components are according to certain ratio combination, can reach the effect of mutual coordination, can enlarge its antimicrobial spectrum, strengthen the effect of anti-bacteria and anti-virus.At present, this type of drug regimen does not appear in the newspapers as yet.An example of optimal drug prescription of the present invention:
Baicalin (purity＞90%) 40%
Chlorogenic acid (purity＞90%) 20%
Forsythoside (purity＞90%) 40%
Another example of optimal drug prescription of the present invention:
Radix Scutellariae general glycoside (purity＞80% is in baicalin) 30%
Flos Lonicerae total organic acids (purity＞40% is in chlorogenic acid) 25%
Fructus Forsythiae general glycoside (purity＞30% is in forsythoside) 45%
Above drug regimen can be made into dosage forms such as capsule, tablet, injection, injectable powder.

Claims (1)

  1. A kind of prescription of antibacterial and antiviral drug, it is characterized in that: Radix Scutellariae general glycoside (purity＞80%, in baicalin) 20-80%, Flos Lonicerae total organic acids (purity＞40%, in chlorogenic acid) 10-70%, Fructus Forsythiae general glycoside (purity＞40% is in forsythoside) 10-70%, and add solid or liquid or the sterile pharmaceutical formulation that appropriate amount of auxiliary materials or excipient are made, or the cosmetics of making according to combinations thereof.
CN 96100031 1996-01-09 1996-01-09 Recipe of antibacterial and antiviral drug Pending CN1154246A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN 96100031 CN1154246A (en) 1996-01-09 1996-01-09 Recipe of antibacterial and antiviral drug
CN 97191640 CN1069545C (en) 1996-01-09 1997-01-08 The antibacterial and antiviral drug composition and method of making the same
PCT/CN1997/000001 WO1997025054A1 (en) 1996-01-09 1997-01-08 An antibacterial or antiviral pharmaceutical composition and preparation thereof
AU13644/97A AU1364497A (en) 1996-01-09 1997-01-08 An antibacterial or antiviral pharmaceutical composition and preparation thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN 96100031 CN1154246A (en) 1996-01-09 1996-01-09 Recipe of antibacterial and antiviral drug

Publications (1)

Publication Number Publication Date
CN1154246A true CN1154246A (en) 1997-07-16

Family

ID=5116435

Family Applications (1)

Application Number Title Priority Date Filing Date
CN 96100031 Pending CN1154246A (en) 1996-01-09 1996-01-09 Recipe of antibacterial and antiviral drug

Country Status (3)

Country Link
CN (1) CN1154246A (en)
AU (1) AU1364497A (en)
WO (1) WO1997025054A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2521554A4 (en) * 2009-12-30 2013-09-11 Purapharm Company Ltd Materials and methods for prevention and treatment of viral infections
KR101438332B1 (en) * 2013-09-05 2014-09-04 경희대학교 산학협력단 Composition for preventing hair loss or promoting hair growth comprising forsythiaside-A
CN105497052A (en) * 2015-12-10 2016-04-20 苏州泽达兴邦医药科技有限公司 Compound medicine mouth wash

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6083921A (en) * 1998-01-12 2000-07-04 Xu; Kai Jian Pharmaceutical compositions and method of using same
US6852739B1 (en) 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
KR20020031608A (en) * 2000-10-19 2002-05-03 이응세 Scutellariae Radix extracts showing a good anti-microbial effect, preparing methods thereof and pharmaceutical compositions containing the same
CN1309399C (en) * 2000-10-25 2007-04-11 国家中药制药工程技术研究中心 Compound 'Shuanghuanglian' preparation and preparing process thereof
US7211590B2 (en) 2002-08-01 2007-05-01 Nitromed, Inc. Nitrosated proton pump inhibitors, compositions and methods of use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1014861B (en) * 1989-05-29 1991-11-27 黑龙江省中医研究院 Method of making dual coptis powder injection
CN1090487A (en) * 1992-12-28 1994-08-10 丛繁滋 Shuanghuanglian aerosol, spray (nose kettle), enema and preparation method thereof
CN1089848A (en) * 1993-01-15 1994-07-27 哈尔滨中药四厂 SHUANGHUANGLIAN JIAONANG and preparation method thereof
CN1090185A (en) * 1993-01-20 1994-08-03 哈尔滨中药四厂 SHUANGHUANGLIAN KOUFUYE and preparation method thereof
CN1091660A (en) * 1993-11-05 1994-09-07 泸州医学院制药厂 The YINHUANG CHONGJI and preparation method thereof and the method for inspection

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2521554A4 (en) * 2009-12-30 2013-09-11 Purapharm Company Ltd Materials and methods for prevention and treatment of viral infections
AU2010337947B2 (en) * 2009-12-30 2015-11-05 Bagi Research Limited Materials and methods for prevention and treatment of viral infections
KR101438332B1 (en) * 2013-09-05 2014-09-04 경희대학교 산학협력단 Composition for preventing hair loss or promoting hair growth comprising forsythiaside-A
CN105497052A (en) * 2015-12-10 2016-04-20 苏州泽达兴邦医药科技有限公司 Compound medicine mouth wash

Also Published As

Publication number Publication date
AU1364497A (en) 1997-08-01
WO1997025054A1 (en) 1997-07-17

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C06 Publication
PB01 Publication
C01 Deemed withdrawal of patent application (patent law 1993)
WD01 Invention patent application deemed withdrawn after publication