CN115400077A - 海龙蛤蚧口服液在制备治疗过敏性鼻炎药物中的应用 - Google Patents
海龙蛤蚧口服液在制备治疗过敏性鼻炎药物中的应用 Download PDFInfo
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Abstract
本申请公开了海龙蛤蚧口服液在制备治疗过敏性鼻炎药物中的应用,属于中药制备领域,本申请制备的海龙蛤蚧口服液补肾阳而不伤阴,具补脾益肺之功,对过敏性鼻炎有较好的治疗作用。
Description
技术领域
本申请涉及海龙蛤蚧口服液在制备治疗过敏性鼻炎药物中的应用,属于中药技术领域。
背景技术
过敏性鼻炎又称变应性鼻炎,是鼻黏膜接触过敏原后由免疫球蛋白E介导的Ⅰ型超敏反应,是耳鼻喉科的常见疾病,属中医“鼻鼽”范畴,其典型症状为鼻痒、鼻塞、阵发性喷嚏和清水样鼻涕,常常会伴有眼红、眼痒等鼻外症状,较为严重者还可能会出现如烦躁易怒、易激惹等情志的改变。因此,过敏性鼻炎非致命性疾病,但反复发作,给患者生活带来很大影响,另外,可能诱发支气管哮喘,甚至发展为哮喘。近年来,过敏性鼻炎在全球的患病率为10%-25%,已成为全球性问题,且本病的发病率呈现逐年上升的趋势。本病的病因学因素主要是遗传因素和环境因素,如自然界的气候变化、空气中的灰尘、刺激性气体。
对于本病的治疗,一般是使用抗组胺药物、糖皮质激素类喷鼻制剂、白三烯受体拮抗剂等药物对症治疗为主。虽然,这些药物在病情发作期能快速地缓解患者的不适症状,但疗效并不能持久,药物毒副作用较大,且会导致病情反复,迁延不愈。中医认为,鼻鼽的发生,乃因肺、脾、肾三脏脏腑功能虚衰,加之机体受风寒等外邪侵袭,鼻窍受邪所致。研究表明,中医辨证治疗,不但可以缓解患者不适症状,还可以调整机体免疫,达到治愈疾病的效果。
发明内容
为了解决上述问题,提供了海龙蛤蚧口服液在制备治疗过敏性鼻炎药物中的应用,本申请制备的海龙蛤蚧口服液补肾阳而不伤阴,具补脾益肺之功,对过敏性鼻炎有较好的治疗作用。
根据本申请的一个方面,提供了海龙蛤蚧口服液在制备治疗过敏性鼻炎药物中的应用。
可选地,所述海龙蛤蚧口服液由中药原料、辅料和水制备而成,所述中药原料由海龙、蛤蚧、人参、羊鞭、羊外肾、黄芩、熟地黄、菟丝子、何首乌、地黄、陈皮、当归、黄芪、阳起石、莲须、甘草、川芎、泽泻、锁阳、豆蔻、沉香、鹿茸、枸杞子、肉苁蓉、淫羊藿、肉桂、韭菜子、蛇床子和花椒组成。
可选地,所述中药原料由海龙39.1g、蛤蚧0.73g、人参4.68g、羊鞭4.68g、羊外肾4.68g、黄芩4.68g、熟地黄3.1g、菟丝子3.1g、何首乌3.1g、地黄3.1g、陈皮3.1g、当归1.56g、黄芪4.68g、阳起石1.56g、莲须1.56g、甘草1.56g、川芎1.56g、泽泻1.56g、锁阳1.56g、豆蔻1.56g、沉香1.56g、鹿茸1.56g、枸杞子1.56g、肉苁蓉0.78g、淫羊藿1.56g、肉桂1.56g、韭菜子1.56g、蛇床子1.56g和花椒0.31g组成。
可选地,所述辅料由蔗糖、苯甲酸和氢氧化钠组成。
可选地,所述辅料由蔗糖300g、苯甲酸1.9g和氢氧化钠组成。
可选地,所述海龙蛤蚧口服液的制备方法包括以下步骤:
(1)将中药原料混合后加水煎煮2次,每次2h,合并两次的煎液,浓缩至相对密度1.04~1.06的清膏,加乙醇,2±2℃冷藏12h,滤过,回收乙醇,再次浓缩至相对密度1.09~1.11的清膏,加水,冷藏,滤过;
(2)取蔗糖300g加水溶解与上述步骤(1)得到的滤液合并,混匀,加苯甲酸1.9g,用焦糖约1.25~1.45g调整颜色为淡棕色至红棕色,用氢氧化钠调节pH至4.6~4.8,同时补充纯化水调整总量至1000ml,滤过,分装,流通蒸汽灭菌后即得。
可选地,步骤(1)中浓缩温度为80℃。
可选地,步骤(1)中乙醇加入量为浓缩清膏的二倍。
可选地,步骤(1)乙醇的质量分数为95%。
本申请的有益效果包括但不限于:
1.本申请开发了海龙蛤蚧口服液在制备治疗过敏性鼻炎药物中的新应用。
2.根据本申请的海龙蛤蚧口服液,配方中重用海龙、羊鞭、羊外肾、鹿茸血肉有情之品以填精补髓,温壮元阳;以菟丝子、肉桂、淫羊藿、莲须、锁阳、韭菜子、蛇床子、肉苁蓉、阳起石辅助之药温补命门,以助温肾壮阳之功。
以人参、黄芪、熟地黄、川芎、当归、枸杞子补益气血活血,益肾脏填精;以花椒、豆蔻、陈皮温中行气、理气健脾;何首乌补肝养血;蛤蚧补肺益虚;以地黄养阴生津,益阴摄阳。扶正不忘祛邪,故又用黄芩、泽泻等泻火利湿,以泻湿浊。以沉香引药归经,甘草调和诸药,诸药相合,大补肾阳而不伤阴,益肾精,补气血,补而不滞,补而不燥,又具补脾益肺之功。
3.根据本申请的海龙蛤蚧口服液,使用苯甲酸做防腐剂,延长保存期限。
具体实施方式
下面结合实施例详述本申请,但本申请并不局限于这些实施例。
除非另行定义,文中所使用的所有专业与科学用语与本领域熟练人员所熟悉的意义相同。本发明所使用的试剂或原料均可通过常规途径购买获得,如无特殊说明,本发明所使用的试剂或原料均按照本领域常规方式使用或者按照产品说明书使用。此外,任何与所记载内容相似或均等的方法及材料皆可应用于本发明方法中。本专利中所述的较佳实施方法与材料仅作示范之用。
实施例1海龙蛤蚧口服液1#
中药原料由海龙39.1g、蛤蚧0.73g、人参4.68g、羊鞭4.68g、羊外肾4.68g、黄芩4.68g、熟地黄3.1g、菟丝子3.1g、何首乌3.1g、地黄3.1g、陈皮3.1g、当归1.56g、黄芪4.68g、阳起石1.56g、莲须1.56g、甘草1.56g、川芎1.56g、泽泻1.56g、锁阳1.56g、豆蔻1.56g、沉香1.56g、鹿茸1.56g、枸杞子1.56g、肉苁蓉0.78g、淫羊藿1.56g、肉桂1.56g、韭菜子1.56g、蛇床子1.56g和花椒0.31g组成。
制备方法为将以上29味中药加水煎煮2次,每次2h,合并煎液,浓缩至相对密度1.05的清膏,浓缩温度为80℃,加浓缩清膏二倍量的乙醇,乙醇的质量分数为95%,2℃冷藏12h,滤过,回收乙醇,浓缩至相对密度1.10的清膏,加水,冷藏,滤过;取蔗糖300g加水溶解与上述滤液合并,混匀,加苯甲酸1.9g,用焦糖1.3g调整颜色为淡棕色至红棕色,用氢氧化钠调pH至4.7,加纯化水调整总量至1000ml,滤过,分装,灭菌,即得海龙蛤蚧口服液1#。
实施例2药理实验研究
1.实验动物及分组:SPF级雄性SD大鼠60只,3月龄,体重180-220g。购于扬州大学医学实验动物中心。随机分作5组:空白组、模型组、治疗组(海龙蛤蚧口服液组)、对比例组(对比例液处方中无海龙,其余组成和制备方法与海龙蛤蚧口服液相同)、西药组(氯雷他定组),每组12只。
造模:全身基础致敏:除空白组大鼠外,其余5组都以0.3mgOVA+5mg Al(OH)3+1mL生理盐水混合液注射小鼠腹腔,隔日1次,总14d。
局部激发强化致敏:腹腔注射免疫阶段结束后,即第15天起,给予5%的卵白蛋白的生理盐水溶液10ul双侧滴鼻,每日1次,连续7天,空白组用相同剂量的生理盐水代替,方法同上。
记录小鼠抓鼻、喷嚏等症状,评分标准:抓鼻≤2次为1分,轻微挠鼻几次为2分,剧烈抓鼻不止为3分;喷嚏1~3个/min为1分,4~10个/min为2分,11个/min以上为3分;清水涕流至前鼻孔为1分,超过前鼻孔为2分,清水涕满面为3分,累计叠加总分大于5分表示造模成功。
2.干预方法:海龙蛤蚧口服液组按照2.3ml/kg给予实施例1制备的海龙蛤蚧口服液1#,对比例组按照2.3ml/kg给予对比例液,氯雷他定组按照0.12mg/kg给予氯雷他定(生理盐水制成混悬液)。于造模成功后的第2d进行灌胃给药处理,空白组和模型组小鼠给予等量的生理盐水溶液灌胃,连续给药14d。
3.观察指标及检测方法:模型复制成功后及治疗第7、10天,对各组大鼠行为学进行评价,评价方法与造模评价方法相同,以叠加法记录总分。治疗结束后,将大鼠以10%水合氯醛腹腔注射麻醉,充分固定后,心脏负压采血,8000r/min离心10min,收集上清液,将血清储存于-80℃冰箱备测,按照ELISA试剂盒说明书检测血清中IgE、IL-6、IL-10含量。具体数据见表1和表2。
表1大鼠行为学评价结果
组别 | 给药前 | 治疗7天 | 治疗10天 |
空白组 | 0.28±0.05 | 0.24±0.04 | 0.32±0.06 |
模型组 | 6.74±1.21 | 4.54±0.84 | 3.72±0.48 |
治疗组 | 6.67±1.57 | 2.77±0.75<sup>abcd</sup> | 1.13±0.05<sup>abcd</sup> |
对比例组 | 6.68±1.72 | 3.50±0.81<sup>a</sup> | 2.32±0.07<sup>a</sup> |
西药组 | 6.55±1.50 | 3.11±0.64<sup>a</sup> | 1.83±0.06<sup>a</sup> |
注:a与给药前比较P<0.05,b与模型组比较P<0.05,c与对比例组比较P<0.05,d与西药组比较P<0.05。
表2血清中IgE、IL-6、IL-10含量
组别 | IgE(mg/L) | IL-6 | IL-10 |
空白组 | 132.38±25.22 | 52.63±8.77 | 301.07±35.53 |
模型组 | 269.48±29.42 | 194.35±17.91 | 121.63±19.95 |
治疗组 | 187.47±21.51<sup>a</sup> | 87.67±6.95<sup>abc</sup> | 248.40±30.23<sup>abc</sup> |
对比例组 | 200.01±17.79 | 123.59±15.26 | 183.24±17.25 |
西药组 | 192.52±16.11 | 105.51±10.49 | 204.51±17.80 |
注:a与给药前比较P<0.05,b与模型组比较P<0.05,c与对比例组比较P<0.05。
4.结果分析
由表1可以看出,给药前模型组、治疗组、对比例组、西药组行为学评分显著高于空白组,提示造模成功,采用海龙蛤蚧口服液治疗7天及10天后,行为学评分显著低于给药前,同时低于同时间段模型组、对比例组、西药组,具有统计学意义,说明海龙蛤蚧口服液在改善过敏性鼻炎症状方面有非常好的作用,且疗效优于对比例组及氯雷他定。由表2可以看出,采用海龙蛤蚧口服液治疗10天后,血清IgE、IL-6水平显著低于同时间段模型组,IL-10水平显著高于同时间段模型组,具有统计学意义,说明海龙蛤蚧口服液可以通过抑制血清中IgE、IL-6水平,提高IL-10水平来减轻炎症反应。另外,治疗10天后海龙蛤蚧口服液组血清IL-6水平低于同时间段对比例组,血清IL-10水平高于同时间段对比例组,具有统计学差异,说明海龙蛤蚧口服液在降低血清IL-6水平,提高IL-10水平方面,疗效优于对比例组。
实施例3临床实验
1.诊断标准
西医诊断标准:参照《变应性鼻炎诊断和治疗指南(2015年,天津)》中变应性鼻炎的诊断标准。①症状:阵发性喷嚏、清水样涕、鼻痒和鼻塞等症状出现2个或以上,每天症状持续或累计在1h以上,可伴有眼痒、流泪和眼红等眼部症状;②体征:常见鼻粘膜苍白、水肿,鼻腔内水样分泌物;③变应原检测:至少一种变应原SPT和/或血清特异性IgE阳性。其中,轻度变应性鼻炎:症状较轻,对生活质量(包括日常生活、工作和学习、睡眠情况)未产生明显影响;持续性变应性鼻炎:症状发作每周超过4d,且持续超过4周(包括4周);常年性变应性鼻炎:症状发作呈常年性。
中医辩证标准:符合中医肾阳虚证的辨证标准。主症:畏寒肢冷;次症:面色白、腰膝部酸痛、神疲乏力、小便清长、大便溏稀。脉细沉,苔白。以上主症符合、舌苔、脉诊符合,次症符合2项以上,则可判断为肾阳虚证。
2.纳入标准:①符合过敏性鼻炎的西医诊断标准;②符合肾阳虚证的中医辨证标准;③符合中、重度患者分类标准;④年龄为18~70岁;⑤依从性好,能够配合治疗。⑥入组前2周内未接受其他鼻炎相关的中西医治疗如使用抗组胺药物、糖皮质激素或针刺、中药治疗等;
排除标准:①药物性鼻炎、急慢性鼻窦炎、鼻腔异物、鼻部解剖异常的患者、鼻恶性肿瘤或需行手术的患者;②合并有严重免疫系统、血液系统以及基础性疾病以及其他影响生存的严重疾病;③妊娠期、哺乳期或有意向妊娠的女性;④对本次用药过敏。
3.治疗方法:观察组:给予海龙蛤蚧口服液1#1次1支,1日2次;对比例组:给予对比例口服液1次1支,1日2次(对比例口服液除配方没有海龙外与海龙蛤蚧口服液相同,制备方法也相同);口服氯雷他定片(商品名:开瑞坦,上海仙灵葆雅制药有限公司),每次10mg,每天一次,晚上睡前服用。服用期内停服其他治疗过敏性鼻炎药物,疗程均为4周。
4.观察及随访:两组均在治疗前(基线期)、治疗过程中的第2周以及第4周(治疗期),通过“四分法”症状评价量表、症状视觉模拟量表(VAS)、鼻结膜炎相关生活质量调査问卷(RQLQ)对患者鼻眼部相关症状及生活质量进行评估,并在第6周(治疗结束后2周)进行随访,观察记录两组患者治疗前后鼻眼部症状的变化情况以及两种不同治疗方法对过敏性鼻炎患者生活质量的影响。
5.疗效评价指标:
1)主要疗效评价指标:参考《变应性鼻炎诊断和治疗指南》(2015年,天津)推荐,主要疗效评价指标包括4个鼻部症状即喷嚏、流涕、鼻痒、鼻塞,2个眼部症状即眼痒/眼红/异物感、流泪。通过“四分法”症状评价量表以及症状视觉模拟量表(VAS)对其进行评价。相关量表见表3。
表3过敏性鼻炎症状评分表
症状 | 四分法症状分级评分 | VAS评分 |
喷嚏 | ||
流涕 | ||
鼻痒 | ||
鼻塞 | ||
眼痒/异物感/眼红 | ||
流泪 |
注:1、四分法计分:无症状为0分;轻度为1分(症状轻微,容易忍受);中度为2分(症状明显,但能忍受);重度为3分(症状难以忍受,影响日常生活)。
2、VAS评分:患者在刻度为0-10的标尺上划线标出各种症状相应的分值,按0-10分进行评价,0代表没有此种症状,10代表此种症状最重。标尺如下:
0
1
2
3
4
5
6
7
8
9
10
2)次要疗效评价指标:鼻结膜炎相关生活质量调查问卷(RQLQ):主要从日常生活中的主要活动受鼻/眼部症状的困扰程度、对睡眠的相关影响、非鼻/眼症状、鼻部症状、眼部症状、生活中遇到的实际问题、情感情绪相关问题等七大部分,评价患者的生活质量受因过敏性鼻炎而出现的鼻/眼部症状的影响程度。相关量表见表4。
表4鼻结膜炎生活治疗调查问卷(RQLQ量表)
注:活动1、2、3为因为您的鼻/眼睛症状而受到限制的3个主要日常活动(该3个主要日常活动从骑自行车、阅读、购物、做家庭维修、做家务活、进出空调房间、看电视、运动或锻炼、晨练、使用电脑、乒乓球、与宠物玩耍、与儿子、孙子玩耍、参加团体体育运动、驾驶、唱歌、正常的社交、性生活、羽毛球、聊天、吃东西、使用吸尘器、拜访亲戚朋友、外出散步、带孩子上下学、户外运动、工作、坐在户外、带孩子上公园、置身吸烟环境中选择)。
3)综合疗效评价指标:
参照《变应行鼻炎的诊治原则合推荐方案》中推荐的疗效评定记分方法:疗效指数=[(治疗前总分-治疗后总分)/治疗前总分]×100%。相关量表见表5。
表5疗效评定分类标准
疗效分类 | 疗效指数 |
治愈 | 体征总分为0 |
显效 | ≥66% |
有效 | 26%-65% |
无效 | ≤25% |
6.研究流程:两组患者均需在治疗开始前、治疗过程中的第2周和第4周、治疗结束后2周,即第6周这四个时间段中,每天填写“四分法”症状评价量表、VAS评分,评价填表当天各鼻眼症状的严重程度,最后取一周的平均分进入统计学分析。
7.研究结果:
共纳入符合纳入标准的过敏性鼻炎患者104例,治疗过程中,治疗组脱落3例,对照组脱落5例、对比例组脱落6例。最终,有90例进入统计学分析:其中,治疗组、对比例组和对照组均为30例。具体结果见表6-表9。
表6海龙蛤蚧口服液治疗后四分法症状评价比较
组别 | 治疗前 | 治疗2周 | 治疗4周 | 治疗结束后2周 |
治疗组 | 13.15±3.61 | 8.74±1.94<sup>a</sup> | 6.51±2.24<sup>ac</sup> | 6.07±1.89<sup>abc</sup> |
对照组 | 12.93±2.98 | 9.37±3.03<sup>a</sup> | 7.12±1.38<sup>a</sup> | 10.17±1.64<sup>a</sup> |
对比例组 | 13.44±3.22 | 9.83±3.59<sup>a</sup> | 7.84±2.36<sup>a</sup> | 7.70±1.25<sup>a</sup> |
注:a与给药前比较P<0.05,b与对照组比较P<0.05,c与对比例组比较P<0.05。
表7海龙蛤蚧口服液治疗后VAS法症状评价比较
注:a与给药前比较P<0.05,b与对照组比较P<0.05,c与对比例组比较P<0.05。
表8海龙蛤蚧口服液治疗后生活质量调查问卷(RQLQ)评价比较
注:a与给药前比较P<0.05,b与对照组比较P<0.05,c与对比例组比较P<0.05。
表9海龙蛤蚧口服液治疗后综合疗效比较[n(%)]
组别 | 显效 | 有效 | 无效 | 总有效 |
治疗组 | 6(20.0) | 19(63.3) | 5(16.7) | 25(83.3) |
对照组 | 4(13.3) | 20(66.6) | 6(20.0) | 24(80.0) |
对比例组 | 3(10.0) | 18(60.0) | 9(30.0) | 21(70.0) |
8.结果分析
由表6可以看出,海龙蛤蚧口服液治疗2周及4周后,喷嚏、流涕、鼻痒、鼻塞等鼻部症状及眼痒/眼红/异物感、流泪等眼部症状明显改善,具有统计学差异,且治疗结束后2周症状无反弹。与对照组和对比例组进行比较,治疗4周后,相关改善优于对比例组,治疗结束后2周相关改善优于对照组和对比例组,均具有统计学差异,说明海龙蛤蚧口服液不但可以较好改善过敏症状且较对比例组及氯雷他定组具有不易反弹的优点。
由表7可以看出,海龙蛤蚧口服液治疗2周及4周后,VAS评分较治疗前显著降低,具有统计学差异,且治疗结束后2周VAS评分无明显升高,说明海龙蛤蚧口服液治疗后鼻部和眼部过敏症状明显减轻,且基本无反弹。与对比例组进行比较,海龙蛤蚧口服液治疗2周及4周后相关改善优于对比例组。治疗结束2周后,VAS评分显著低于对比例组和西药组,具有统计学差异。
由表8可以看出,海龙蛤蚧口服液治疗2周及4周后,RQLQ评分较治疗前显著降低,具有统计学差异,且治疗结束后2周RQLQ评分无明显升高,说明海龙蛤蚧口服液治疗组患者生活质量明显提高,且改善能保持基本无反弹。与对比例组进行比较,治疗2周及4周后,相关改善显著优于对比例组,治疗4周后,相关改善显著优于西药组,治疗结束2周后,相关改善显著优于对比例组和西药组,具有统计学差异。由表9可以看出,海龙蛤蚧口服液治疗4周后,综合有效率为83.3%,西药组为80.0%,对比例组为70.0%,海龙蛤蚧口服液组综合有效率最高。
以上所述,仅为本申请的实施例而已,本申请的保护范围并不受这些具体实施例的限制,而是由本申请的权利要求书来确定。对于本领域技术人员来说,本申请可以有各种更改和变化。凡在本申请的技术思想和原理之内所作的任何修改、等同替换、改进等,均应包含在本申请的保护范围之内。
Claims (9)
1.海龙蛤蚧口服液在制备治疗过敏性鼻炎药物中的应用。
2.根据权利要求1所述的应用,其特征在于,所述海龙蛤蚧口服液由中药原料、辅料和水制备而成,所述中药原料由海龙、蛤蚧、人参、羊鞭、羊外肾、黄芩、熟地黄、菟丝子、何首乌、地黄、陈皮、当归、黄芪、阳起石、莲须、甘草、川芎、泽泻、锁阳、豆蔻、沉香、鹿茸、枸杞子、肉苁蓉、淫羊藿、肉桂、韭菜子、蛇床子和花椒组成。
3.根据权利要求2所述的应用,其特征在于,所述中药原料由海龙39.1g、蛤蚧0.73g、人参4.68g、羊鞭4.68g、羊外肾4.68g、黄芩4.68g、熟地黄3.1g、菟丝子3.1g、何首乌3.1g、地黄3.1g、陈皮3.1g、当归1.56g、黄芪4.68g、阳起石1.56g、莲须1.56g、甘草1.56g、川芎1.56g、泽泻1.56g、锁阳1.56g、豆蔻1.56g、沉香1.56g、鹿茸1.56g、枸杞子1.56g、肉苁蓉0.78g、淫羊藿1.56g、肉桂1.56g、韭菜子1.56g、蛇床子1.56g和花椒0.31g组成。
4.根据权利要求2所述的应用,其特征在于,所述辅料由蔗糖、苯甲酸和氢氧化钠组成。
5.根据权利要求4所述的应用,其特征在于,所述辅料由蔗糖300g、苯甲酸1.9g和氢氧化钠组成。
6.根据权利要求5所述的应用,其特征在于,所述海龙蛤蚧口服液的制备方法包括以下步骤:
(1)将中药原料混合后加水煎煮2次,每次2h,合并两次的煎液,浓缩至相对密度1.04~1.06的清膏,加乙醇,在2±2℃下冷藏12h,滤过,回收乙醇,再次浓缩至相对密度1.09~1.11的清膏,加水,冷藏,滤过;
(2)取蔗糖300g加水溶解与上述步骤(1)得到的滤液合并,混匀,加苯甲酸1.9g,用焦糖约1.25~1.45g调整颜色为淡棕色至红棕色,用氢氧化钠调节pH至4.6~4.8,同时补充纯化水调整总量至1000ml,滤过,分装,流通蒸汽灭菌后即得。
7.根据权利要求6所述的应用,其特征在于,步骤(1)中浓缩温度为80℃。
8.根据权利要求6所述的应用,其特征在于,步骤(1)中乙醇加入量为浓缩清膏的二倍。
9.根据权利要求6所述的应用,其特征在于,步骤(1)乙醇的质量分数为95%。
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CN102218122A (zh) * | 2011-04-13 | 2011-10-19 | 济南宏济堂制药有限责任公司 | 一种海龙蛤蚧口服液的质量控制检测方法 |
CN114099612A (zh) * | 2021-12-01 | 2022-03-01 | 河南善翌行医药科技有限公司 | 蛤蚧定喘中药组合物在治疗鼻炎中的应用 |
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CN1368151A (zh) * | 2001-02-02 | 2002-09-11 | 杨孟君 | 纳米海龙蛤蚧制剂药物及其制备方法 |
CN102218122A (zh) * | 2011-04-13 | 2011-10-19 | 济南宏济堂制药有限责任公司 | 一种海龙蛤蚧口服液的质量控制检测方法 |
CN114099612A (zh) * | 2021-12-01 | 2022-03-01 | 河南善翌行医药科技有限公司 | 蛤蚧定喘中药组合物在治疗鼻炎中的应用 |
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