CN115397859A - 治疗癌症和癌症转移的联合疗法 - Google Patents

治疗癌症和癌症转移的联合疗法 Download PDF

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Publication number
CN115397859A
CN115397859A CN202180026925.1A CN202180026925A CN115397859A CN 115397859 A CN115397859 A CN 115397859A CN 202180026925 A CN202180026925 A CN 202180026925A CN 115397859 A CN115397859 A CN 115397859A
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cancer
antibody
inhibitor
antibodies
treatment
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CN202180026925.1A
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English (en)
Chinese (zh)
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S·阿兹纳尔·贝尼塔
P·G·阿门多拉
V·范霍伦
M·德·弗里亚斯·桑切斯
B·莫兰乔·阿米森
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Ona Therapy Co ltd
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Ona Therapy Co ltd
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Publication of CN115397859A publication Critical patent/CN115397859A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
CN202180026925.1A 2020-01-30 2021-01-29 治疗癌症和癌症转移的联合疗法 Pending CN115397859A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202062967875P 2020-01-30 2020-01-30
EP20382054.3 2020-01-30
EP20382054 2020-01-30
US62/967,875 2020-01-30
PCT/IB2021/050747 WO2021152548A1 (en) 2020-01-30 2021-01-29 Combination therapy for treatment of cancer and cancer metastasis

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Publication Number Publication Date
CN115397859A true CN115397859A (zh) 2022-11-25

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CN202180026925.1A Pending CN115397859A (zh) 2020-01-30 2021-01-29 治疗癌症和癌症转移的联合疗法

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US (1) US20230086099A1 (cg-RX-API-DMAC10.html)
EP (1) EP4097130A1 (cg-RX-API-DMAC10.html)
JP (1) JP2023512276A (cg-RX-API-DMAC10.html)
KR (1) KR20220133996A (cg-RX-API-DMAC10.html)
CN (1) CN115397859A (cg-RX-API-DMAC10.html)
AU (1) AU2021213969A1 (cg-RX-API-DMAC10.html)
BR (1) BR112022014962A2 (cg-RX-API-DMAC10.html)
CA (1) CA3168923A1 (cg-RX-API-DMAC10.html)
IL (1) IL295093A (cg-RX-API-DMAC10.html)
MX (1) MX2022009270A (cg-RX-API-DMAC10.html)
WO (1) WO2021152548A1 (cg-RX-API-DMAC10.html)

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WO2021176424A1 (en) 2020-03-06 2021-09-10 Ona Therapeutics, S.L. Anti-cd36 antibodies and their use to treat cancer
CA3226281A1 (en) * 2021-07-30 2023-02-02 ONA Therapeutics S.L. Anti-cd36 antibodies and their use to treat cancer
WO2023172863A1 (en) * 2022-03-07 2023-09-14 Elixiron Immunotherapeutics (hong Kong) Limited Anti-cd36 antibodies and uses thereof
CN117462687A (zh) * 2022-07-20 2024-01-30 清华大学 一种用于制备预防或治疗骨转移癌药物的组合物及其应用
CN118697878B (zh) * 2024-05-28 2025-02-11 广东省人民医院 Cd36作为抑制肺癌脑膜转移的分子标志物和治疗靶点的应用

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Publication number Publication date
IL295093A (en) 2022-09-01
WO2021152548A1 (en) 2021-08-05
BR112022014962A2 (pt) 2022-09-20
CA3168923A1 (en) 2021-08-05
EP4097130A1 (en) 2022-12-07
JP2023512276A (ja) 2023-03-24
MX2022009270A (es) 2022-10-27
US20230086099A1 (en) 2023-03-23
AU2021213969A1 (en) 2022-09-01
KR20220133996A (ko) 2022-10-05

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Application publication date: 20221125