CN115380980A

CN115380980A - Composition for inhibiting hyperuricemia and application thereof

Info

Publication number: CN115380980A
Application number: CN202211239804.8A
Authority: CN
Inventors: 邓连意
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-10-13
Filing date: 2022-10-11
Publication date: 2022-11-25
Also published as: CN113854381A

Abstract

The application provides a composition for inhibiting hyperuricemia and application thereof, medicinal and edible medicinal materials are adopted as materials, spleen and kidney tonifying is mainly performed, liver soothing and lung ventilating are assisted, a small amount of blood circulation promoting and stasis removing products are used for activating tendons and collaterals, the composition has the effects of regulating viscera balance, regulating qi, clearing and dissolving stasis and recovering metabolic balance of viscera, has the advantages of rigorous and proper component material proportion, balanced chills and fever, yin and yang tonifying, yin and yang storage and rising, and achieves the state of yin and yang balance, and has a health-care effect, an obvious effect and high economic value.

Description

Composition for inhibiting hyperuricemia and application thereof

Technical Field

The invention belongs to the technical field of health-care drinks, and particularly relates to a composition for inhibiting hyperuricemia and application thereof.

Background

Hyperuricemia has become a common disease for many urban people due to diet irregularity and poor living habits, and gout caused by hyperuricemia is painful. It is doubtful that once uric acid is high, the normal state is difficult to recover, and people who have developed gout can attack gout even though diet is usually controlled but food with high purine is slightly eaten. Modern medicine considers this to be a disorder of purine metabolism, in which defects in certain enzymes can cause uric acid increase. Many people think that purine is not beneficial to human bodies, and preferably eat food containing purine at least, actually purine has important physiological functions for human bodies and is a component of some important enzymes of the human bodies, purine metabolic disorder can cause the production of uric acid to be increased, and useful enzyme synthesis is reduced, so that the physiological functions of the human bodies are seriously influenced. The traditional Chinese medicine considers that hyperuricemia is turbid phlegm substance of human body, and the regulation function of viscera is unbalanced due to the damage of liver, spleen and kidney, phlegm stasis and mutual resistance, so that the metabolism function of the body is disordered. Regulating uric acid requires starting from regulating visceral functions rather than simply promoting uric acid excretion.

Pathological analysis of hyperuricemia: according to traditional Chinese medicine theory of visceral manifestation, the spleen is the acquired root, and can digest food into minute substances, and absorb, transmit and distribute food essence for normal movement of human body. The essential substances refer to various nutritional components in blood, and can provide sufficient nutrition to viscera, tissues and organs. Improper diet can lead to retention of damp-heat in the middle-jiao, dysfunction of the spleen in transportation, and accumulation of turbid phlegm obstructing qi movement. The transportation and transformation function of the spleen determines that food becomes essential substances required by the human body rather than turbid phlegm. The human body is an organic whole, the viscera have close relationships, and the liver and spleen are all in the middle energizer of the human body and are important viscera for digestion and absorption of food. The physiological function of the liver is to dredge, which can assist the digestion of the spleen and stomach, regulate the qi movement of the spleen and stomach, and maintain the qi of the spleen and stomach to ascend clear and descend turbid, thereby ensuring normal digestive absorption. Bad living habits such as staying up all night, drinking, high psychological stress and the like easily cause the impairment of the function of liver smoothing flow of qi and influence the transportation and transformation functions of the spleen. In addition, liver diseases must transmit the spleen first, and the relationship between the liver and spleen is like a hard brother and a difficult brother, which help each other and restrict each other, so that it can be seen that the spleen moves, the liver qi is well-developed, the digestion and absorption of human body are normal, and purine can be metabolized normally. The metabolite of purine is uric acid, and is mostly excreted from the body by the kidneys through the urine regardless of normal metabolism. Kidneys govern water, and they have the function of qi transformation, playing an important role in regulating the distribution and excretion of body fluids, and maintaining the metabolic balance of body fluids. Liver and kidney are a pair of twin brothers, and have the same source of essence and blood, mutual function of storing and releasing, mutual resource of yin and yang, so that they are all damaged, and the regulation of liver cannot be ignored when regulating kidney. In addition, in the aspect of body fluid metabolism, the spleen and kidney need to be closely matched to ensure that the body fluid metabolism is normally performed, the transportation and transformation functions of the spleen are not only the transportation and transformation of food essence but also the transportation and transformation of water, and the metabolism of body fluid requires the transportation and transformation of the spleen and the transformation of the kidney, so that the spleen and the kidney can promote the excretion of uric acid from urine. For regulating uric acid in human body, applicants think that the lung function should be emphasized, and the lung is a very important organ in regulating water metabolism in human body. The physiological function of the lung is mainly to regulate water channels, the lung qi disperses and governs opening and closing of striae, and the sweat excretion is regulated, so that uric acid in part of blood can be discharged through the sweat; descending the lung can continuously transport water from the body downward, and the qi transformation of the kidney and bladder can generate urine to be discharged out of the body, and can also promote the discharge of uric acid.

Through the analysis of the theory, the reduction of uric acid is the coordination of multiple organs fundamentally, and the uric acid is not simply promoted to be discharged out of the body. Strengthening the spleen and soothing the liver to promote the spleen to move, no source of phlegm and turbidity, and the transportation and transformation function of the spleen is vigorous to promote the qi transformation function of the lung to regulate the water channel and the kidney, so as to accelerate the discharge of phlegm and turbidity; nourishing liver and tonifying kidney, strengthening qi of kidney, eliminating phlegm turbidity, supplementing liver and kidney qi, invigorating spleen, and regulating kidney qi by yin and yang deficiency; ventilating lung, lowering qi, strengthening lung, regulating water passage, and promoting water metabolism; has the effects of promoting blood circulation, removing blood stasis, dredging the meridian and promoting blood circulation to assist in clearing away the turbid.

However, many uric acid-lowering products on the market are generally cold and cool and are not suitable for long-term drinking, for example, chinese invention patent (patent number: CN 201811632419.3) discloses a composition for treating gout, which is prepared from the following raw materials in parts by weight: 45-55 parts of honeysuckle, 25-35 parts of dandelion, 10-20 parts of lucid ganoderma, 2-8 parts of gastrodia elata, 2-8 parts of American ginseng, 2-8 parts of viper, 10-20 parts of chrysanthemum, 10-20 parts of raspberry and 10-20 parts of mulberry. Therefore, it is highly desirable to provide a uric acid-lowering composition with balanced cold and heat and capable of regulating the functions of the viscera.

Disclosure of Invention

The invention aims to overcome the defects of the prior art, and provides a composition for inhibiting hyperuricemia, which is mainly used for strengthening spleen and tonifying kidney, soothing liver and freeing lung, is assisted by a small amount of blood circulation-promoting and stasis-removing products, has the effects of regulating viscera balance, regulating qi, clearing turbidity, removing stasis and recovering metabolism balance of viscera, has strict and proper component material proportion, balanced chills and fever, nourishing yin and yang, and has the state of keeping yin and raising yang to achieve yin-yang balance, a health-care effect, an obvious effect and high economic value.

A composition for inhibiting hyperuricemia comprises the following raw materials in parts by weight: 25-35 parts of mulberry, 25-35 parts of hyacinth bean flower, 15-25 parts of dried orange peel, 15-25 parts of medlar, 5-15 parts of eucommia male flower, 5-15 parts of chrysanthemum, 5-15 parts of honeysuckle flower and 1-3 parts of saffron.

The application provides a composition for inhibiting hyperuricemia, medicinal and edible medicinal materials are adopted as materials, the hyacinth dolichos flower in the formula has the effects of tonifying spleen and eliminating dampness, is sweet but not greasy, is good at tonifying spleen and assisting transportation and eliminating dampness, the mulberry has the effects of nourishing yin, enriching blood, tonifying liver and kidney, the spleen and the kidney are monarch drugs, and the hyacinth dolichos flower is matched with the dried orange peel for tonifying spleen and regulating qi, so that the spleen is promoted to move, strengthen, invigorate and smooth qi; the mulberry is matched with eucommia male flowers for tonifying liver and kidney yang qi, and can seek yang from yin and balance yin and yang with the deficiency of tonifying liver and kidney, and the two medicines are ministerial medicines. The chrysanthemum is used for calming liver fire, the medlar is used for nourishing liver yin, and the dried orange peel is used for soothing liver and regulating qi, so that the liver qi is smoothly released by matching the three medicines; both Ju Hua and jin Yin Hua are heat-clearing and toxicity-removing herbs to clear heat from viscera and smooth qi movement, and these three herbs are used as adjuvant drugs, while Chen Pi is also used as adjuvant drug. The long-term phlegm obstruction of qi movement to generate blood stasis, the saffron promotes blood circulation to dissipate blood stasis, and cools blood and detoxifies as a guiding drug, so that the meridians and collaterals are regulated, and the qi movement is smooth and unobstructed.

Further, the raw material ratio of the hyacinth bean flower to the dried orange peel is preferably 1:1-3:2, more preferably 3:2, the dried orange peel in the formula is prepared from two red peels produced in a new meeting after aging for more than three years, the qi regulating effect is more enhanced compared with that of the big red peels, compared with the green peels, the two red peels have no strong effect of breaking qi of the green peels, so the dried orange peel in the formula is mild and regulates qi, the spleen strengthening effect is slightly weaker, the hyacinth bean flower and the dried orange peel in the formula are both spleen strengthening products, the hyacinth bean flower is better at strengthening the spleen, the qi tonifying effect is more beneficial to the restoration of the spleen function, and the dried orange peels are more suitable to be used as monarch drugs, the hyacinth bean flower gas is light, and the usage amount of the hyacinth bean flower needs to be increased; hyacinth dolichos flowers are flowers, and are easy to disperse qi, and the dried orange peel with qi-lowering effect can effectively prevent too much diffusion, so the dosage ratio of hyacinth beans to dried orange peel is close to 3:2 is most suitable.

Further, the raw material ratio of the mulberry, the medlar and the eucommia male flower is preferably 2-3:1-2:1-2, more preferably 3:2:1, the mulberry is mild and slow in drug property, the eucommia male flower is quick in drug property diffusion, the dosage of the mulberry needs more, and if the eucommia male flower is too much, the whole formula is excited too much, and instead, the yin liquid is consumed; medlar is a product with yang in yin, can tonify liver and kidney yin and can also assist yang qi, eucommia male flower is also a product with yang-tonifying effect, and if too many products are used in the formula, the products with yang-tonifying effect can be easily moved and can damage human bodies. The proportion just can tonify yin and yang, and the state that yin rises yang to reach yin-yang balance is stored; the medlar in the formula is Qinghai Chailau medlar instead of Ningxia medlar, each effective component in Qinghai medlar is higher than Ningxia medlar, comparison of sense organs of the Qinghai medlar shows that the Chailau medlar is sweeter and more resistant to soaking, and is more suitable for being used in tea, and finally the use of Chailau medlar instead of Ningxia medlar is confirmed.

Furthermore, the raw material ratio of the chrysanthemum to the honeysuckle is preferably 1:1-2, more preferably 1:1, the chrysanthemum and the honeysuckle have the effects of clearing heat and removing toxicity, and the chrysanthemum is cold in nature and can clear heat, the chrysanthemum in the formula is Huangshan tribute chrysanthemum, the tribute chrysanthemum has the effects of dispelling wind and heat, calming the liver and improving eyesight and clearing heat and removing toxicity compared with Hangzhou white chrysanthemum, but the tribute chrysanthemum is a full-bloom flower, volatile matters of the tribute chrysanthemum are lighter and better at clearing lung heat upwards, the Hangzhou white chrysanthemum is better at clearing liver heat, and the tribute chrysanthemum is selected for achieving a better lung ventilating effect; the honeysuckle flower in the recipe is selected from Malus hupehensis Rehd, which contains flavone, inositol and saponin which are not contained in the honeysuckle flower in other areas, and has the characteristics of large flower bud, pure color, faint scent taste and high chlorogenic acid content.

Further, the ratio of the usage amount of the mulberries, the chrysanthemum and the honeysuckle to the usage amount of the dried orange peels, the medlar, the eucommia male flowers and the saffron is preferably 1:1-1, the cold and cool objects can hurt yang qi after being eaten for a long time, modern people can hurt yang qi due to lack of outdoor activities, love for drinking cold drinks and stay under an air conditioner for a long time, and can be subjected to double injuries if eating cold and cool objects for a long time, the mulberries, the chrysanthemum and the honeysuckle in the application formula are cold-natured objects, the dried orange peels, the medlar, the eucommia male flowers and the saffron are warm-natured objects, the hyacinth dolichos is neutral in nature, and the usage amount ratio of the cold and hot objects is close to 1:1, the chrysanthemum and the honeysuckle can break the balance by one more, one less and one less, the whole formula of the health-care tea can not be cold and dry, has nourishing effect in clearing away heat, has intermittent in moving and balanced yin and yang, and is the health-care tea which can be drunk for a long time.

Furthermore, the saffron is the material with the least dosage in the formula, the saffron with the production place of Iran is adopted, the saffron is an indispensable material, the efficacy of the whole formula is weakened after the saffron is reduced, but the effect of promoting blood circulation to remove blood stasis is more rapid, the dosage is too much, the bleeding is easily caused, and the cost performance of the saffron is reduced when too much saffron is used.

Further, the paint is preferably prepared from the following raw materials in parts by weight: 30 parts of mulberry, 30 parts of hyacinth bean flower, 20 parts of dried orange peel, 20 parts of medlar, 10 parts of eucommia male flower, 10 parts of chrysanthemum, 10 parts of honeysuckle and 2 parts of saffron. The materials and the proportion of the formula are strict, the rings are buckled, the efficacy of each material can be fully exerted, and the nutritional value of 1+1 > 2 is produced.

The invention also aims to provide the application of the composition for inhibiting high uric acid in preparation of a product for reducing uric acid, common flowers and fruits are taken as raw materials, the taste is fragrant and sweet, the composition can be used as health-care tea, health-care tea or substitute tea, compared with a plurality of tea prescriptions on the market, the tea prescription is food and not a prescription, the composition can be taken after being mixed with water when being drunk, and the composition does not need to be boiled, so that the public acceptance is higher; the natural taste and fragrance of the flowers and fruits are ingeniously utilized, and the fragrant and sweet five sense organs experience can be achieved without adding artificial flavoring agents; medicinal and edible medicinal materials are used as materials, so that the health-care tea has a health-care effect, obvious efficacy and high economic value.

Compared with the prior art, the invention has the following advantages:

1. the application provides a composition for inhibiting hyperuricemia, which adopts medicinal and edible medicinal materials as materials, mainly strengthens the spleen and tonifies the kidney, soothes the liver and releases the lung as an auxiliary material, and simultaneously uses a small amount of blood-activating and stasis-removing products for activating the tendons and collaterals, has the effects of regulating the balance of viscera, regulating qi, removing the turbid urine and the blood stasis and recovering the metabolic balance of the viscera, has the advantages of rigorous and proper component material proportion, balanced chills and fever, nourishing yin and yang, storing yin and raising yang to reach the state of balancing yin and yang, has a health-care effect, remarkable effect and high economic value.

2. The application provides an application of a composition for inhibiting hyperuricemia in preparation of a product for reducing the uric acid, the full formula of the application takes common flowers and fruits as raw materials, the components are simple, the formula is reasonable, the preparation is convenient, the taste is fragrant and sweet, the composition can be used as health-care tea, health-care tea or substitute tea, compared with a plurality of tea formulas on the market, the tea formula is a food instead of a prescription, the tea can be taken after being mixed with water when being drunk, the boiling is not needed, the public acceptance is higher, the natural taste and fragrance in the flowers and fruits are ingeniously utilized in the formula, the artificial flavoring agent is not needed to be added, and the fragrant and sweet five sense organs experience can be achieved; medicinal and edible medicinal materials are used as materials, so the Chinese medicinal composition has a health-care effect, obvious effect and high economic value.

Detailed Description

The following is a detailed description of the present invention:

the specific technical scheme of the invention is illustrated by combining specific examples 1-5:

example 1:

a composition for inhibiting hyperuricemia comprises the following raw materials in parts by weight: 30 parts of mulberry, 30 parts of hyacinth bean flower, 20 parts of dried orange peel, 20 parts of medlar, 10 parts of eucommia male flower, 10 parts of chrysanthemum, 10 parts of honeysuckle and 2 parts of saffron.

The application of the composition for inhibiting the hyperuricemia is to mix the raw materials according to the mixture ratio and take 13.5g of boiled water to soak 1500ml of the raw materials for drinking.

Example 2:

a composition for inhibiting hyperuricemia comprises the following raw materials in parts by weight: 30 parts of mulberry, 25 parts of hyacinth bean flower, 25 parts of dried orange peel, 20 parts of medlar, 10 parts of eucommia male flower, 10 parts of chrysanthemum, 10 parts of honeysuckle and 2 parts of saffron.

The application of the composition for inhibiting the hyperuricemia is to mix the raw materials according to the mixture ratio and take 14g of boiled water to soak 1500ml of the mixture for drinking.

Example 3:

a composition for inhibiting hyperuricemia comprises the following raw materials in parts by weight: 25 parts of mulberry, 30 parts of hyacinth bean flower, 20 parts of dried orange peel, 25 parts of medlar, 15 parts of eucommia male flower, 10 parts of chrysanthemum, 10 parts of honeysuckle and 2 parts of saffron.

The application of the composition for inhibiting the hyperuricemia is to mix the raw materials according to the mixture ratio and take 13g of boiled water to soak 1500ml of the mixture for drinking.

Example 4:

a composition for inhibiting hyperuricemia comprises the following raw materials in parts by weight: 35 parts of mulberry, 30 parts of hyacinth bean flower, 20 parts of dried orange peel, 15 parts of medlar, 15 parts of eucommia male flower, 15 parts of chrysanthemum, 15 parts of honeysuckle and 2 parts of saffron.

The application of the composition for inhibiting the hyperuricemia is to mix the raw materials according to the mixture ratio and take 15g of boiled water to soak 1500ml of the raw materials for drinking.

Example 5:

a composition for inhibiting hyperuricemia comprises the following raw materials in parts by weight: 30 parts of mulberry, 30 parts of hyacinth bean flower, 20 parts of dried orange peel, 20 parts of medlar, 10 parts of eucommia male flower, 10 parts of chrysanthemum and 10 parts of honeysuckle.

The application of the composition for inhibiting the hyperuricemia is to mix the raw materials according to the mixture ratio and take 14.5g of boiled water to soak 1500ml of the raw materials for drinking.

Comparative example 1:

a composition for treating gout, which is disclosed by the invention patent in China (patent number: CN 201811632419.3), is prepared by weighing the following raw materials in parts by weight: 50 parts of honeysuckle, 30 parts of dandelion, 15 parts of lucid ganoderma, 5 parts of gastrodia elata, 5 parts of American ginseng, 5 parts of pit viper, 15 parts of chrysanthemum, 15 parts of raspberry and 15 parts of mulberry; adding 15 times of water according to the weight ratio, soaking in cold water for 40min, heating and extracting for 2 times, each time for 2h, collecting and combining the extracting solutions, concentrating under reduced pressure, standing and cooling to obtain the extract of the composition for treating gout;

table 1: in examples 1 to 5, the raw material components were mixed in the proportions (parts by weight)

Raw materials	Example 1	Example 2	Example 3	Example 4	Example 5
						Mulberry fruit	30	30	25	35	30
Hyacinth bean flower	30	25	30	30	30
						Dried orange peel	20	25	20	20	20
Chinese wolfberry	20	20	25	15	20
						Eucommia male flower	10	10	15	15	10
(Chrysanthemum)	10	10	10	15	10
						Honeysuckle	10	10	10	15	10
Saffron crocus	2	2	2	2	0

To verify the effect of the present invention in inhibiting hyperuricemic acid compositions in reducing uric acid, the applicant conducted the following clinical studies:

1. patients with uric acid values higher than 430 μmol/L, aged 30-60 years, were selected and included in the study 15 days before taking the uric acid lowering drugs, 87 men and 53 women were randomly divided into 6 groups, 40 groups and 20 groups of 2-6.

2. The taking method comprises the following steps: the composition for inhibiting the hyperuricemia prepared in the embodiment is brewed with 13-15g of boiled water for 1500ml, and is drunk for multiple times every day, and a treatment course is 30 days after continuous drinking.

3. The treatment effect evaluation standard is as follows: the blood uric acid level of the patients is compared, and the experimental results are divided into three levels according to the evaluation standards related to the gout curative effect:

the effect is shown: the blood uric acid is obviously reduced (less than or equal to 380 mu mol/L for men and less than or equal to 320 mu mol/L for women) after 30 days of treatment, the range is stabilized during treatment, and the symptom disappearance function of patients is recovered after treatment;

the method has the following advantages: after 30 days of treatment, the blood uric acid value is reduced to normal (380 mu mol/L < male ≤ 420 mu mol/L,320 mu mol/L < female ≤ 360 mu mol/L), or the blood uric acid is not reduced to normal after treatment, but the blood uric acid is reduced by 50 mu mol/L compared with that before treatment, and the main symptoms of the patient basically disappear.

And (4) invalidation: after 30 days of treatment, the blood uric acid value is not reduced or is reduced, but the symptoms of patients before and after treatment are not improved.

Total effective rate = (effective + effective)/total instances 100%.

4. Results

The clinical efficacy results are shown in table 2:

group of	Number of cases	Clothes case	Show effect	Is effective	Invalidation	Display efficiency	Total effective rate
								Group 1	40	Example 1	21	17	2	52.50％	95.00％
Group 2	20	Example 2	7	11	2	35.00％	90.00％
								Group 3	20	Example 3	5	11	4	25.00％	80.00％
Group 4	20	Example 4	4	13	3	20.00％	85.00％
								Group 5	20	Example 5	3	13	4	15.00％	80.00％
Group 6	20	Comparative example 1	0	9	11	0％	45.00％

Typical cases are:

case 1: wu Mou, male, 59 years old, beijing Haihu people, and applicant treated in September 2021, the gout history of 2 years is shown, the detection shows that the uric acid value is 485 mu mol/L, the ankle of the right foot is red and swollen, the pain is serious, the hyperuricemia inhibiting composition of the invention 1 is continuously taken, 1500ml is taken every day, the uric acid value is reduced to 428 mu mol/L after two weeks, the symptom is completely disappeared after one month, and the recurrence is avoided after follow-up.

Case 2: meng Mou, male, 55 years old, shenzhen Futian, 2022, 6 months old visit the applicant for treatment, gout and red swelling of the left ankle diagnosed before the last 5 years, examination shows that the uric acid level is 449 mu mol/L, and treatment: 1500ml of the composition for inhibiting hyperuricemia in example 2 of the application is drunk every day, the pain of the left ankle can be relieved and the swelling can be relieved after one week, the symptom disappears after the composition is continuously taken for 1 month, the uric acid value is detected to be reduced to 401 mu mol/L, and the follow-up is carried out till now, and no relapse occurs.

Case 3: in case of a male who is 32 years old and suffering from gout caused by frequent drinking of beer, the gout is manifested as swelling of joints of left toes and severe pain, and the self-checking uric acid value reaches 549 mu mol/L.

Case 4: in a forest, male and 33 years old, the gout has been known for 2 years since the history, people often drink cold drinks and work under a long-term air conditioner, exercise is lacked, examination shows that 525 mu mol/L of uric acid, red swelling and pain of the big toe of the right foot occur, after drinking the composition for treating gout in comparative example 1 of the application for half a month, the symptoms such as cold hands and feet, diarrhea, soreness and weakness of waist and knees and the like appear, then the administration is stopped, after medical consultation, spleen-kidney yang qi damage is diagnosed, body yin-yang imbalance is caused, and the patients recover after taking Chinese patent medicines for warming yang and tonifying kidney for conditioning.

The research results show that:

the composition for inhibiting the hyperuricemia prepared in the embodiment 1 is taken in group 1, the effect is best, 21 cases are effective in 40 cases, 17 cases are effective, the significant rate and the total effective rate are 52.5% and 95% respectively, the hyacinth bean flower in the formula has the effects of tonifying spleen and resolving dampness, is sweet but not greasy, excels at tonifying spleen, assisting transportation and resolving dampness, the mulberry has the effects of nourishing yin, tonifying blood, tonifying liver and kidney, tonifying spleen and tonifying kidney are monarch drugs, and the hyacinth bean flower is matched with the pericarpium citri reticulatae which has the effects of tonifying spleen and regulating vital energy, and assisting spleen in moving, strengthening and invigorating qi and smoothing qi; the mulberry is matched with eucommia male flowers for tonifying liver and kidney yang qi, and can seek yang from yin and balance yin and yang with the deficiency of tonifying liver and kidney, and the two medicines are ministerial medicines. The chrysanthemum is used for calming liver fire, the medlar is used for nourishing liver yin, and the dried orange peel is used for soothing liver and regulating qi, so that the liver qi is smoothly dredged by matching the three medicines; both Ju Hua and jin Yin Hua are heat-clearing and toxicity-removing herbs to clear heat of zang-fu organs and smooth qi movement, so these three herbs are used as adjuvant drugs and Chen Pi is also used as adjuvant drug. The long-term phlegm obstruction of qi movement to generate blood stasis, the saffron promotes blood circulation to remove blood stasis, and the blood cooling and detoxifying function as guiding drugs, so that the meridians are regulated and the qi movement is smooth;

the composition for inhibiting the hyperuricemia prepared in the example 2 is taken in the group 2, wherein 7 cases are effective in 20 cases, 11 cases are effective, the significant rate and the total effective rate are 35% and 90%, respectively, the effect is not good in the example 1, and the difference between the example 2 and the example 1 is that the raw material ratio of the hyacinth bean flower to the dried orange peel in the example 1 is 3:2, in example 2, the raw material ratio of the hyacinth bean flower to the dried orange peel is 1:1, because the hyacinth dolichos flower and the dried orange peel in the formula are spleen-tonifying products, the hyacinth dolichos flower is better at tonifying the spleen, has the effect of tonifying qi, is more beneficial to the restoration of the spleen function, and is more suitable to be used as a monarch drug, the hyacinth dolichos flower is light in smell, and the using amount of the hyacinth dolichos flower needs to be increased; hyacinth dolichos flowers are flowers, and are easy to disperse qi, and the tangerine peel for depressing qi can effectively prevent too much dispersing qi, so that the dosage proportion of hyacinth beans and tangerine peel is close to 3:2 is most suitable;

group 3 taking the composition for inhibiting hyperuricemia prepared in example 3, 20 cases of the composition have 8 cases of significant effect and 11 cases of significant effect, the significant rate and the total effective rate are 40% and 95% respectively, the effect is not good as that of example 1, and the difference between example 3 and example 1 is that the raw material ratio of mulberry, medlar and eucommia male flower in example 1 is 3:2:1, the raw material ratio of the mulberry, the medlar and the eucommia male flower in the embodiment 3 is 5:5:3, the mulberry is mild and slow in drug property, the eucommia male flower is quick in drug property diffusion, the dosage of the mulberry needs more, and if the eucommia male flower is too much, the whole formula is over excited, and instead, the yin liquid is consumed; medlar is a product with yang in yin, can tonify liver and kidney yin and can also assist yang qi, eucommia male flower is also a product with yang-tonifying effect, and if too many products are used in the formula, the products with yang-tonifying effect can be easily moved and can damage human bodies. Therefore, the proportion in the embodiment 1 is selected to just supplement yin and yang, so that the yin is stored and the yang is raised to reach the state of balancing yin and yang;

grouping 4, taking the composition for inhibiting hyperuricemia prepared in example 4, 20 cases show effect 4, 13 cases show effect, the remarkable rate and the total effective rate are 20% and 85%, respectively, the effect is not good in example 1, example 4 is different from example 1 in that the ratio of the dosage of mulberry, chrysanthemum and honeysuckle to the dosage of dried orange peel, medlar, eucommia male flower and saffron in example 1 is 1.04, while the ratio of the dosage of mulberry, chrysanthemum and honeysuckle to the dosage of dried orange peel, medlar, eucommia male flower and saffron in example 1 is 1:1, the chrysanthemum and the honeysuckle can break the balance by one more, one less and one less, and the formula of the example 1 is not cold and not dry, has nourishing effect in clearing heat, has intermittent circulation and balancing yin and yang, and is health-care and health-preserving tea which can be drunk for a long time;

the composition for inhibiting the high uric acid prepared in the example 5 is taken in group 5, 10 cases are effective in 20 cases, 8 cases are effective, the significant rate and the total effective rate are respectively 50% and 90%, the effect is not good in the example 1, the example 5 is different from the example 1 in that the saffron is not contained, the saffron is the material with the least dosage in the formula, the saffron is an indispensable material, the effect of the whole formula is weakened when the saffron is reduced, but the effect of the whole formula is strengthened when the composition is used, the blood stasis removing force is rapid, the bleeding is easily caused when the dosage is too high, and the cost performance of the composition is reduced when too much saffron is used.

The composition for treating gout prepared in the comparative example 1 is taken in group 6, 0 is significant in 20 cases, 9 are significant in 20 cases, the significant rate and the total effective rate are respectively 0% and 45%, and most of the patients have the symptoms of cold fearing, cold hands and feet, fatigue, no spirit, soreness and weakness of waist and knees, gastric acid, gastrectasia, stomachache, abdominal pain, stool unshaped, temperature preference, aversion to cold, clear and long urine, pale tongue fur, white pulse and the like due to the fact that most of the components in the comparative example 1 are cold in nature, spleen and kidney yang qi damage can be caused by long-term drinking, so that yin and yang imbalance of the body can be caused, dandelion, honeysuckle and mulberry in the comparative example 1 are cold in nature, chrysanthemum and American ginseng are cold in nature, yang qi can be damaged by long-term drinking, modern people can easily damage spleen and stomach by long-term drinking cold in the air conditioner due to lack of activities, and the viscera with cold in the cold nature can be damaged by double cold in a long term, and the cold in the spleen and stomach can be easily damaged by long-drinking, and the modern people can only drink uric acid with the function of regulating kidney qi for a long time, and the simple drinking of the comparative example 1 can be used for regulating uric acid.

The above description is only exemplary of the present application and should not be taken as limiting the present application, as any modification, equivalent replacement, or improvement made within the spirit and principle of the present application should be included in the protection scope of the present application.

Claims

1. A hyperuricemic acid inhibiting composition, comprising: the composition is prepared from the following raw materials in parts by weight: 25-35 parts of mulberry, 25-35 parts of hyacinth bean flower, 15-25 parts of dried orange peel, 15-25 parts of medlar, 5-15 parts of eucommia male flower, 5-15 parts of chrysanthemum, 5-15 parts of honeysuckle flower and 1-3 parts of saffron.

2. The hyperuricemic inhibiting composition according to claim 1, wherein the raw material ratio of the hyacinth bean flower to the dried orange peel is 1:1-3:2.

3. the hyperuricemic inhibiting composition according to claim 2, wherein the raw material ratio of the hyacinth bean flower to the dried orange peel is 3:2.

4. the hyperuricemia inhibiting composition according to claim 1, wherein the raw material ratio of the mulberry, the medlar and the eucommia male flower is 2-3:1-2:1-2.

5. The hyperuricemia inhibiting composition according to claim 4, wherein the raw material ratio of the mulberry, the medlar and the eucommia male flower is 3:2:1.

6. the hyperuricemia inhibiting composition according to claim 1, wherein the raw material ratio of chrysanthemum to honeysuckle is 1:1-2.

7. The hyperuricemic inhibiting composition of claim 1, wherein the ratio of the amount of the mulberry, the chrysanthemum and the honeysuckle to the amount of the tangerine peel, the medlar, the eucommia male flower and the saffron is 1:1-1.

8. The hyperuricemic inhibiting composition according to any one of claims 1-7, which comprises the following raw materials in parts by weight: 30 parts of mulberry, 30 parts of hyacinth bean flower, 20 parts of dried orange peel, 20 parts of medlar, 10 parts of eucommia male flower, 10 parts of chrysanthemum, 10 parts of honeysuckle and 2 parts of saffron.

9. Use of the composition for inhibiting hyperuricemia according to claims 1-8 in the preparation of a product for reducing uric acid.

10. The use of the composition for inhibiting hyperuricemia according to claim 9, wherein the uric acid lowering product is any one of a health tea, a health tea or a substitute tea.