CN115380915A - Disinfecting composition and method and use thereof - Google Patents
Disinfecting composition and method and use thereof Download PDFInfo
- Publication number
- CN115380915A CN115380915A CN202210653503.3A CN202210653503A CN115380915A CN 115380915 A CN115380915 A CN 115380915A CN 202210653503 A CN202210653503 A CN 202210653503A CN 115380915 A CN115380915 A CN 115380915A
- Authority
- CN
- China
- Prior art keywords
- parts
- nano
- silica
- methyl vinyl
- vinyl sulfone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 38
- 230000000249 desinfective effect Effects 0.000 title claims description 11
- 238000000034 method Methods 0.000 title claims description 11
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 74
- WUIJTQZXUURFQU-UHFFFAOYSA-N 1-methylsulfonylethene Chemical compound CS(=O)(=O)C=C WUIJTQZXUURFQU-UHFFFAOYSA-N 0.000 claims abstract description 27
- -1 polyhexamethylene guanidine Polymers 0.000 claims abstract description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 26
- 239000000645 desinfectant Substances 0.000 claims abstract description 22
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 21
- 239000005543 nano-size silicon particle Substances 0.000 claims abstract description 16
- 235000012239 silicon dioxide Nutrition 0.000 claims abstract description 13
- 239000000377 silicon dioxide Substances 0.000 claims description 39
- 238000003756 stirring Methods 0.000 claims description 12
- 230000010355 oscillation Effects 0.000 claims description 8
- 241000711573 Coronaviridae Species 0.000 claims description 6
- 239000008367 deionised water Substances 0.000 claims description 6
- 229910021641 deionized water Inorganic materials 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 5
- 238000011282 treatment Methods 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 2
- 238000011012 sanitization Methods 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000008901 benefit Effects 0.000 abstract description 7
- 230000001954 sterilising effect Effects 0.000 abstract description 7
- 231100000956 nontoxicity Toxicity 0.000 abstract description 6
- 239000004753 textile Substances 0.000 abstract description 6
- 238000000576 coating method Methods 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 4
- 230000009471 action Effects 0.000 abstract description 3
- 239000003054 catalyst Substances 0.000 abstract description 3
- 238000002485 combustion reaction Methods 0.000 abstract description 3
- 238000004880 explosion Methods 0.000 abstract description 3
- 230000007794 irritation Effects 0.000 abstract description 3
- 230000007774 longterm Effects 0.000 abstract description 3
- 231100000957 no side effect Toxicity 0.000 abstract description 3
- 239000011819 refractory material Substances 0.000 abstract description 3
- 238000001228 spectrum Methods 0.000 abstract description 3
- 238000010586 diagram Methods 0.000 description 16
- 238000012360 testing method Methods 0.000 description 14
- 238000002474 experimental method Methods 0.000 description 9
- 238000001514 detection method Methods 0.000 description 8
- 206010037660 Pyrexia Diseases 0.000 description 4
- 230000000843 anti-fungal effect Effects 0.000 description 4
- 229940121375 antifungal agent Drugs 0.000 description 4
- 238000004332 deodorization Methods 0.000 description 4
- 239000004744 fabric Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 229910052814 silicon oxide Inorganic materials 0.000 description 4
- 229920000742 Cotton Polymers 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 239000000443 aerosol Substances 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 3
- 239000001963 growth medium Substances 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- XYHKNCXZYYTLRG-UHFFFAOYSA-N 1h-imidazole-2-carbaldehyde Chemical compound O=CC1=NC=CN1 XYHKNCXZYYTLRG-UHFFFAOYSA-N 0.000 description 2
- GWYFCOCPABKNJV-UHFFFAOYSA-M 3-Methylbutanoic acid Natural products CC(C)CC([O-])=O GWYFCOCPABKNJV-UHFFFAOYSA-M 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 206010021143 Hypoxia Diseases 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- GWYFCOCPABKNJV-UHFFFAOYSA-N beta-methyl-butyric acid Natural products CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 230000009351 contact transmission Effects 0.000 description 2
- 230000009365 direct transmission Effects 0.000 description 2
- 230000007954 hypoxia Effects 0.000 description 2
- 239000010985 leather Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000000644 propagated effect Effects 0.000 description 2
- 230000009385 viral infection Effects 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 208000010444 Acidosis Diseases 0.000 description 1
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 208000028399 Critical Illness Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 208000006083 Hypokinesia Diseases 0.000 description 1
- 206010027417 Metabolic acidosis Diseases 0.000 description 1
- 206010028748 Nasal obstruction Diseases 0.000 description 1
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 description 1
- 206010039101 Rhinorrhoea Diseases 0.000 description 1
- 206010040070 Septic Shock Diseases 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000017574 dry cough Diseases 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 210000001508 eye Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 208000037797 influenza A Diseases 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 238000005555 metalworking Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 210000003928 nasal cavity Anatomy 0.000 description 1
- 208000010753 nasal discharge Diseases 0.000 description 1
- 244000309711 non-enveloped viruses Species 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000003805 procoagulant Substances 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 230000036303 septic shock Effects 0.000 description 1
- 206010041232 sneezing Diseases 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
- 238000012956 testing procedure Methods 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N41/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom
- A01N41/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom containing a sulfur-to-oxygen double bond
- A01N41/10—Sulfones; Sulfoxides
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a durable and efficient disinfection composition which comprises methyl vinyl sulfone, polyhexamethylene guanidine and nano silicon dioxide. The invention comprises the following steps: 1. the advantage of using methyl vinyl sulfone in the present invention is that it is an extremely effective disinfectant; in several indirect food contact applications, effective over a wide pH range (2-11); has no irritation to skin. 2. The polyhexamethylene guanidine used in the composition has the advantages of broad sterilization spectrum, low effective concentration, high action speed, stable property, easy water solubility, long-term bacteriostasis, no side effect, no corrosivity, no color, no odor, no toxicity, no combustion, no explosion, safe use, moderate price and convenient transportation. 3. The invention has the advantages of excellent cohesiveness, film forming property, activity, large specific surface area, no toxicity, no odor and the like, and can be widely applied to the industries of electronics, catalysts, refractory materials, coatings, printing ink, textiles, food and the like.
Description
Technical Field
The invention relates to a disinfection composition, a method and application thereof, belonging to the technical field of novel coronavirus disinfectants.
Background
The clinical manifestations of pneumonia patients infected with the novel coronavirus are as follows: the symptoms of fever, hypodynamia and dry cough are mainly manifested, and symptoms of upper respiratory tract such as nasal obstruction, watery nasal discharge and the like are rare, and the hypoxia and hypoxia state can occur. Approximately half of patients develop dyspnea after one week, and severe patients rapidly progress to acute respiratory distress syndrome, septic shock, refractory metabolic acidosis, and procoagulant dysfunction. It is noted that the severe and critically ill patients may have moderate or low fever during their course, even without significant fever. Some patients have slight onset symptoms, no fever, and mostly recover after one week. The prognosis is good for most patients, and the disease is critical and even death for a few patients.
The novel routes of coronavirus transmission are mainly direct transmission, aerosol transmission and contact transmission. Direct transmission refers to infection caused by sneezing, cough, and talking droplet of the patient, and the exhaled air is inhaled directly at a short distance; aerosol transmission refers to the mixing of droplets in the air to form an aerosol which causes infection after inhalation; contact transmission refers to the condition that droplets are deposited on the surface of an article and contact with mucous membranes such as oral cavity, nasal cavity, eyes and the like after contacting with contaminated hands, so that infection is caused.
Currently, the main disinfection methods for the novel coronavirus are: ultraviolet rays, ozone, 75% alcohol, chlorine-containing disinfectants, and the like. These sterilization methods have a certain degree of influence on the indoor environment or have a certain degree of risk to human health. Therefore, there is a strong need for a disinfecting composition, method and use thereof to solve the problems of the prior art.
In order to solve the technical problems, a new technical scheme is especially provided.
Disclosure of Invention
The present invention aims to provide a disinfecting composition, a method and use thereof to solve the problems set forth in the background art.
In order to achieve the purpose, the invention provides the following technical scheme: a disinfectant composition comprises methyl vinyl sulfone, polyhexamethylene guanidine, and nanometer silica
Preferably, further comprises deionized water.
Preferably, the weight portion of the methyl vinyl sulfone is 0.02-2, the weight portion of the polyhexamethylene guanidine is 0.02-2, and the weight portion of the nano silicon dioxide is 5-40.
Preferably, the weight part of the ionized water is 60-95 parts.
Preferably, the weight part of the methyl vinyl sulfone is 0.3 part, the weight part of the polyhexamethylene guanidine is 0.3 part, and the weight part of the nano silicon dioxide is 16 parts.
Preferably, the weight part of the ionized water is 83.4 parts.
A method for preparing the disinfectant composition as claimed in any one of claims 2 to 6, wherein the disinfectant composition of the present invention is prepared by adding nano-silica to ionized water, dissolving the nano-silica by ultrasonic oscillation and stirring to obtain a nano-silica solution, adding methyl vinyl sulfone and polyhexamethylene guanidine to the nano-silica solution, mixing and stirring.
Preferably, 83.4 parts of ionized water is taken, 16 parts of nano-silica is added, the nano-silica is dissolved by ultrasonic oscillation and stirring to obtain a nano-silica solution, 0.3 part of methyl vinyl sulfone and 0.3 part of polyhexamethylene guanidine are added into the nano-silica solution, and the mixture is mixed and stirred to prepare 100 parts of the disinfection composition.
Preferably, 74 parts of ionized water is added with 25 parts of nano-silica, the nano-silica is dissolved by ultrasonic oscillation and stirring to obtain a nano-silica solution, 0.5 part of methyl vinyl sulfone and 0.5 part of polyhexamethylene guanidine are added into the nano-silica solution, and the mixture is mixed and stirred to prepare 100 parts of the disinfection composition.
Use of a disinfecting composition as claimed in any one of claims 1 to 6 in a medicament or disinfectant for the prophylaxis or treatment of a novel coronavirus.
Compared with the prior art, the invention has the beneficial effects that:
1. the advantage of using methyl vinyl sulfone in the present invention is that it is an extremely effective disinfectant; in several indirect food contact applications, effective over a wide pH range (2-11); has no irritation to skin.
2. The polyhexamethylene guanidine used in the composition has the advantages of broad sterilization spectrum, low effective concentration, high action speed, stable property, easy water solubility, long-term bacteriostasis, no side effect, no corrosivity, no color, no odor, no toxicity, no combustion, no explosion, safe use, moderate price and convenient transportation. It is an environment-friendly multipurpose novel polymer, and has wide application in industry, agriculture, medical use and daily life.
3. The composition of the present invention comprises nanosilica and deionized water. The nano silicon dioxide and the deionized water are mixed to form the nano silicon oxide transparent liquid, the pH value range is 6.8-8.3, the nano silicon oxide transparent liquid has excellent cohesiveness, film forming property, activity, large specific surface area, no toxicity, no odor and other properties, and is widely applied to the industries of electronics, catalysts, refractory materials, coatings, printing ink, textiles, food and the like.
Drawings
FIG. 1 is a block diagram of the experiment of the present invention during different experimental periods of the antibacterial experiment.
FIG. 2 is a photograph of a medium on which AF disinfectant has been sprayed 14 days after the course of the antibiotic experiment of the present invention.
FIG. 3 is a photograph of a culture medium which was not sterilized after 14 days during the course of the antibiotic experiment in accordance with the present invention.
FIG. 4 is a block diagram of experiments performed during different experimental periods during the antifungal testing process of the present invention.
FIG. 5 is a photograph of a dry cloth that has been sprayed with AF disinfectant after 14 days during the antifungal testing of FIG. 5.
FIG. 6 is a photograph of the dried cloth of FIG. 5 after 14 days of the antifungal testing procedure without a disinfecting treatment.
FIG. 7 is a block diagram 1 showing the analysis and detection results of the disinfectant solution containing silica according to the present invention.
FIG. 8 is a block diagram 2 showing the analysis and detection results of the disinfectant solution containing silica according to the present invention.
FIG. 9 is a block diagram 3 showing the analysis and detection results of the disinfectant solution containing silica according to the present invention.
FIG. 10 is a block diagram 4 showing the analysis and detection results of the disinfectant solution containing silica according to the present invention.
FIG. 11 is a block diagram 5 showing the analysis and detection results of the disinfection solution with silica according to the present invention.
FIG. 12 is a schematic diagram showing comparison of the inactivation effect of AF on influenza A (non-enveloped virus) in the test result diagram of the virus according to the present invention.
FIG. 13 is a block diagram showing the time variation of the virus infection rate versus the reduction value in the block diagram of the test results of AF versus virus according to the present invention.
FIG. 14 is a block diagram showing the detection of Staphylococcus aureus reduction of more than 99.9% at the end of the sterilization experiment according to the present invention.
FIG. 15 is a block diagram showing the detection of the E.coli reduction of 99.9% or more at the end of the sterilization experiment according to the present invention.
FIG. 16 is a block diagram showing the measurement of ammonia gas in the deodorization measurement according to the present invention.
FIG. 17 is a block diagram showing the measurement of (acetic) acid gas in the deodorization measurement according to the present invention.
FIG. 18 is a block diagram showing the results of isovaleric acid deodorization testing according to the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention are clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The invention provides a technical scheme that: a disinfectant composition comprises methyl vinyl sulfone, polyhexamethylene guanidine, nano silicon dioxide and ionized water, wherein the methyl vinyl sulfone, the polyhexamethylene guanidine, the nano silicon dioxide and the ionized water in the disinfectant account for the following weight percentage: 0.02-2 parts of methyl vinyl sulfone, 0.02-2 parts of polyhexamethylene guanidine, 5-40 parts of nano silicon dioxide and 60-95 parts of ionic water.
Preferably, the disinfectant comprises the following components in percentage by weight: 0.3 part of methyl vinyl sulfone, 0.3 part of polyhexamethylene guanidine, 16 parts of nano silicon dioxide and 83.4 parts of ionic water.
Preferably, 83.4 parts of ionized water is taken, 16 parts of nano-silica is added, and the nano-silica is dissolved by ultrasonic oscillation and stirring to obtain a nano-silica solution.
Preferably, 0.3 part of methyl vinyl sulfone and 0.3 part of polyhexamethylene guanidine are added into the nano silicon dioxide solution, and the mixture is mixed and stirred to prepare 100 parts of the disinfection composition, namely the AF disinfection solution.
Preferably, 74 parts of ionized water is taken, 25 parts of nano-silica is added, and the nano-silica is dissolved by ultrasonic oscillation and stirring to obtain a nano-silica solution.
Preferably, 0.5 part of methyl vinyl sulfone and 0.5 part of polyhexamethylene guanidine are added into the nano-silica solution, and mixed and stirred to prepare 100 parts of the disinfection composition.
The compositions of the present invention comprise methyl vinyl sulfone. Methyl vinyl sulfone has a CAS registry number of 3680-02-2.. Methyl vinyl sulfone is an antimicrobial agent that is widely used to control degradation by bacteria. It has been EPA certified for registration and can be used in adhesives, paper coatings, plastics, tanned leather, caulks, metalworking fluids, textiles, coatings, and wood preservation. The advantage of using methyl vinyl sulfone is that it is an extremely effective disinfectant; in several indirect food contact applications, FDA approval in the united states; effective over a wide pH range (2-11); has no irritation to skin.
The composition of the invention comprises polyhexamethylene guanidine. Polyhexamethylene guanidine is an environment-friendly high-molecular polymer disinfectant, and is also named as polyhexamethylene guanidine (hydrochloride). The polyhexamethylene guanidine has the advantages of broad sterilization spectrum, low effective concentration, high action speed, stable property, easy water solubility, long-term bacteriostasis, no side effect, no corrosiveness, no color, no odor, no toxicity, no combustion, no explosion, safe use, moderate price and convenient transportation. It is an environment-friendly multipurpose novel polymer, and has wide application in industry, agriculture, medical use and daily life.
The invention adopts the combination of methyl vinyl sulfone, polyhexamethylene guanidine and nano silicon dioxide in the disinfection composition. The aging test report of the silicon dioxide disinfectant is as follows:
1. and (5) performing an antibacterial experiment.
As shown in fig. 1 to 3, 100% all-cotton textiles purchased in the market were divided into two. And the dried sample was used as a mold growth test. The above is 28 degrees +/-2 degrees. And 100% of all-cotton textile fabric samples are pasted on the inorganic agar culture medium. The same amount is added.
2. And (4) antifungal testing.
As shown in figures 4 to 6, 100% of all-cotton cloth purchased from the market was divided in half, one half of which was sprayed with AF cleaning disinfectant on the surface and the other half was subjected to the mold growth test in the normal manner. The sample is pasted on an inorganic agar culture medium, the temperature is controlled to be about thirty degrees, and the humidity is controlled to be about 85 percent, so that the test is carried out. And (5) carrying out wet process and placing.
Moreover, the above test environment was converted into a practical evaluation standard, and seven days were about three months, and 14 days were about one year.
The composition of the present invention comprises nanosilica and deionized water. The nano silicon dioxide and the deionized water are mixed to form the nano silicon oxide transparent liquid, the pH value range is 6.8-8.3, the nano silicon oxide transparent liquid has excellent cohesiveness, film forming property, activity, large specific surface area, non-toxicity, tasteless and other properties, is widely applied to the industries of electronics, catalysts, refractory materials, coatings, printing ink, textiles, food and the like, and has specific application scenes that: bedding and pillowcase. Blankets, sponge mattresses, shoe cabinets, leather shoes, boots, socks, western-style clothes, and underwear. Curtain, wall paper, sofa, air conditioner filter, garbage bin. Washing machines, washing rooms, toilets and the like have a space around the water. Beds and living spaces, bathrooms. Sporting goods, bags, and the like.
In the experiment, as shown in fig. 12 and 13, the test results of AF on virus were that the virus infection rate was reduced by 3.7 × 10 after 15 minutes of use 10 The above.
As shown in fig. 14 and 15, the detection results of the sterilization test: after 1 minute of use, staphylococcus aureus and escherichia coli both decreased by more than 99.9%.
As shown in fig. 16, 17 and 18, the experimental conclusion of the deodorization test is that: the odor generated by ammonia gas, (acetic) acid gas and isovaleric acid is basically eliminated in a short time. The principle of benefiting is that the bad smell of the mould is generated when the spores are divided and propagated, AF disinfection solution is directly sprayed on the mould, the mould stops being propagated and died immediately, and the mould smell disappears.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (10)
1. A disinfecting composition comprising methyl vinyl sulfone, polyhexamethylene guanidine, and nanosilica.
2. The sanitizing composition according to claim 1, wherein: further comprising deionized water.
3. The sanitizing composition according to claim 1, wherein: 0.02-2 parts of methyl vinyl sulfone, 0.02-2 parts of polyhexamethylene guanidine and 5-40 parts of nano silicon dioxide.
4. The sanitizing composition according to claim 2, wherein: taking 60-95 parts of ionized water by weight.
5. A disinfecting composition as recited in claim 3, characterized in that the parts by weight of methyl vinyl sulfone are 0.3 parts, the parts by weight of polyhexamethylene guanidine are 0.3 parts, and the parts by weight of nano-silica are 16 parts.
6. A disinfecting composition as claimed in claim 4, characterized in that the part by weight of the ionized water is 83.4 parts.
7. A process for preparing a disinfecting composition according to any one of claims 2 to 6, characterized in that: adding nano-silica into ionized water, dissolving the nano-silica by ultrasonic oscillation and stirring to obtain a nano-silica solution, adding methyl vinyl sulfone and polyhexamethylene guanidine into the nano-silica solution, and mixing and stirring to prepare the disinfection composition.
8. The sanitizing composition according to claim 8 wherein: taking 83.4 parts of ionized water, adding 16 parts of nano-silica, dissolving the nano-silica by ultrasonic oscillation and stirring to obtain a nano-silica solution, adding 0.3 part of methyl vinyl sulfone and 0.3 part of polyhexamethylene guanidine into the nano-silica solution, and mixing and stirring to prepare 100 parts of the disinfection composition.
9. The sanitizing composition, method and use thereof according to claim 8 wherein: taking 74 parts of ionized water, adding 25 parts of nano-silica, dissolving the nano-silica by ultrasonic oscillation and stirring to obtain a nano-silica solution, adding 0.5 part of methyl vinyl sulfone and 0.5 part of polyhexamethylene guanidine into the nano-silica solution, and mixing and stirring to prepare 100 parts of the disinfection composition.
10. A disinfecting composition as claimed in any one of claims 1 to 6 characterized by: use in a medicament or disinfectant for the prevention or treatment of a novel coronavirus.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210653503.3A CN115380915A (en) | 2022-06-09 | 2022-06-09 | Disinfecting composition and method and use thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210653503.3A CN115380915A (en) | 2022-06-09 | 2022-06-09 | Disinfecting composition and method and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115380915A true CN115380915A (en) | 2022-11-25 |
Family
ID=84115963
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210653503.3A Pending CN115380915A (en) | 2022-06-09 | 2022-06-09 | Disinfecting composition and method and use thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115380915A (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB147535A (en) * | 1919-07-12 | 1920-12-30 | Gyoergy Kereszty | A process for the production of bleaching and disinfecting agents |
| FR2063601A5 (en) * | 1969-10-23 | 1971-07-09 | Roussel Uclaf | 1-methylsulphonyl 1-mercury acetoxy 2-methoxy ethane - biocide for treatment of industrial wastes |
| US20020028215A1 (en) * | 1999-08-09 | 2002-03-07 | Jagath L. Kadurugamuwa | Novel vaccines and pharmaceutical compositions using membrane vesicles of microorganisms, and methods for preparing same |
| CN1425069A (en) * | 1999-11-24 | 2003-06-18 | 丹尼斯科有限公司 | Method for purifying proteins |
| KR20140108931A (en) * | 2013-03-04 | 2014-09-15 | (주)신일섬유 | Woven fabrics for beddings |
| WO2016050567A1 (en) * | 2014-10-01 | 2016-04-07 | Syngenta Participations Ag | Insecticidal cyanotropane derivatives |
| CN113749114A (en) * | 2021-06-24 | 2021-12-07 | 广州安富环保科技有限公司 | Disinfecting composition and method and use thereof |
-
2022
- 2022-06-09 CN CN202210653503.3A patent/CN115380915A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB147535A (en) * | 1919-07-12 | 1920-12-30 | Gyoergy Kereszty | A process for the production of bleaching and disinfecting agents |
| FR2063601A5 (en) * | 1969-10-23 | 1971-07-09 | Roussel Uclaf | 1-methylsulphonyl 1-mercury acetoxy 2-methoxy ethane - biocide for treatment of industrial wastes |
| US20020028215A1 (en) * | 1999-08-09 | 2002-03-07 | Jagath L. Kadurugamuwa | Novel vaccines and pharmaceutical compositions using membrane vesicles of microorganisms, and methods for preparing same |
| CN1425069A (en) * | 1999-11-24 | 2003-06-18 | 丹尼斯科有限公司 | Method for purifying proteins |
| KR20140108931A (en) * | 2013-03-04 | 2014-09-15 | (주)신일섬유 | Woven fabrics for beddings |
| WO2016050567A1 (en) * | 2014-10-01 | 2016-04-07 | Syngenta Participations Ag | Insecticidal cyanotropane derivatives |
| CN113749114A (en) * | 2021-06-24 | 2021-12-07 | 广州安富环保科技有限公司 | Disinfecting composition and method and use thereof |
Non-Patent Citations (1)
| Title |
|---|
| 李云捷等, 成都：西南交通大学出版社 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6956143B2 (en) | Antimicrobial composition and how to use it | |
| JP2000503662A (en) | Fast-acting chemical sterilant | |
| CN105816343A (en) | Quick-drying surgical hand disinfection solution and preparation method thereof | |
| CN101293107A (en) | Broad spectrum biological disinfection air filtering material and preparation method thereof | |
| CN108391673A (en) | A kind of preparation method of nano silver/quaternary ammonium salt compound disinfectant | |
| KR20230086564A (en) | Eco -friendly disinfection and deodorant | |
| CN113749114A (en) | Disinfecting composition and method and use thereof | |
| CN1093134A (en) | Sanitary wet towel for baby | |
| CN110477792A (en) | A kind of nonalcoholic wet tissue and preparation method thereof can be used for breathing mask cleaning-sterilizing | |
| EP0609106B1 (en) | A glutaraldehyde composition | |
| JP3786663B2 (en) | Disinfection and sterilization method of wet wiper using aqueous solution containing chlorine dioxide, hypochlorite and ferrous sulfate | |
| CN115380915A (en) | Disinfecting composition and method and use thereof | |
| CN112189670A (en) | Non-corrosive, non-irritant and disinfectant sanitary wet tissue and manufacturing method thereof | |
| CN111500490A (en) | Microbial type bacteriostatic and odor-removing preparation as well as preparation method and application thereof | |
| CN102762981A (en) | Peracid and 2-hydroxy organic acid compositions and methods for treating items | |
| JPS59157007A (en) | Disinfectant | |
| CN116471936A (en) | Method and use for producing a composition that stably contains free available chlorine species and peroxide | |
| CN111802405B (en) | Aqueous solution antibacterial disinfectant and preparation method and application thereof | |
| CN104490936A (en) | Skin disinfectant | |
| CN104784164A (en) | Protein-based skin cleaning disinfectant and preparation method thereof | |
| WO2022239605A1 (en) | Virucidal agent | |
| CN108324732A (en) | A kind of skin and mucosa hand sanitizing fluid | |
| McLeod et al. | Sterilisation of the skin: the time factor in the action of antiseptics and the possibilities of local application of antibiotics | |
| JPS6357502A (en) | Antiseptic composition for finger | |
| US2310099A (en) | Deodorant |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20221125 |
|
| WD01 | Invention patent application deemed withdrawn after publication |