CN108324732A - A kind of skin and mucosa hand sanitizing fluid - Google Patents
A kind of skin and mucosa hand sanitizing fluid Download PDFInfo
- Publication number
- CN108324732A CN108324732A CN201810245427.6A CN201810245427A CN108324732A CN 108324732 A CN108324732 A CN 108324732A CN 201810245427 A CN201810245427 A CN 201810245427A CN 108324732 A CN108324732 A CN 108324732A
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- CN
- China
- Prior art keywords
- skin
- mucosa
- product
- hand sanitizing
- sanitizing fluid
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
Abstract
The invention discloses a kind of skin and mucosa hand sanitizing fluids, which is characterized in that has following material composition：Poly hexamethylene biguanide 0.30 ~ 0.40% (w/v), acetic acid chlorhexidine 0.10 ~ 0.20% (w/v), water：Surplus.The present invention is colorless and odorless without precipitating liquid, and formula is simple, Disinfection Effect is good, will not generate stimulation and toxicity to skin or mucous membrane, stability is up to 24 months.
Description
Technical field
The invention belongs to pharmaceutical sanitary fields, are related to a kind of skin and mucosa hand sanitizing fluid.
Background technology
Currently, there are many skin mucosa disinfectant type, but certain stimulation can be generated to skin or mucous membrane when in use.It is existing
Having the thimerosal in technology to usually contain povidone iodine, guanidine fungicide, alcohol etc. has the ingredient of sterilization, and it is formulated
Complexity causes combined effect poor.
Invention content
The present invention relates to a kind of skin and mucosa hand sanitizing fluids.
Technical solution of the present invention is as follows：
A kind of skin and mucosa hand sanitizing fluid, there is following material composition：
Poly hexamethylene biguanide 0.30 ~ 0.40% (w/v)
Acetic acid chlorhexidine 0.10 ~ 0.20% (w/v)
Water surplus.
Further, poly hexamethylene biguanide purity >=99%.
Further, acetic acid chlorhexidine purity >=97.5%.
Further, water is purified water.
The present invention is colorless and odorless without precipitating liquid, and formula is simple, Disinfection Effect is good, will not be generated to skin or mucous membrane
Stimulation and toxicity, stability are up to 24 months.
Compared with prior art, the present invention has the following advantages：
1, the present invention is environment-friendly type macromolecule polymer disinfection sanitizer.
2, the present invention has the ability of extremely strong killing bacterium, has the characteristics that wide sterilization spectrum, efficient；
3, the present invention can use at normal temperatures, and the antibacterial time is long, without side-effects, safely and effectively.
4, the present invention is nontoxic, colourless, odorless；It is non-ignitable, not quick-fried；
5, the present invention is non-corrosive to a variety of materials；
6, the present invention is without harmful substances such as iodine, chlorine, aldehyde.
Specific implementation mode
With reference to embodiment, the present invention is further described.
Embodiment 1
A kind of skin and mucosa hand sanitizing fluid, there is following material composition：
Poly hexamethylene biguanide 0.30% (w/v)
Acetic acid chlorhexidine 0.10% (w/v)
Water surplus.
Embodiment 2
A kind of skin and mucosa hand sanitizing fluid, there is following material composition：
Poly hexamethylene biguanide 0.40% (w/v)
Acetic acid chlorhexidine 0.20% (w/v)
Water surplus.
Embodiment 3
A kind of skin and mucosa hand sanitizing fluid, there is following material composition：
Poly hexamethylene biguanide 0.35% (w/v)
Acetic acid chlorhexidine 0.15% (w/v)
Water surplus.
Embodiment 4
It is configured to 1 by the stoste of embodiment 1 ~ 3 and with water:1 dilution, by the Ministry of Public Health《Disinfection technology standard》（2002
Year version）In quantitative disinfecting test method tested, with Escherichia coli, staphylococcus aureus, Pseudomonas aeruginosa and white read
Pearl bacterium acts on 1 minute.The results are shown in table below for it：
Embodiment 5
Toxicological experiment is carried out to embodiment 1 ~ 3, the results are shown in table below：
Embodiment 6
The application method of the present invention is as follows：
1）Surgery hand, skin degerming：It after washing one's hands by specification, is washed down with flowing water, is dried with sterile towel, appropriate this product stoste is taken to set
In the centre of the palm, both hands rubbing to forearm；Proper amount of disinfectant stoste is taken to repeat to wipe primary, disinfecting time 3-5 minutes again.
2）Hygienic hand-wrist bones：Take 2~5ml of this product on hand, rubbing both hands act on 1 minute, spontaneously dry.
3）Operation and injection site skin, trauma wound and general place skin degerming：Take this product with cotton swab embrocate in
Position to be sterilized wipes 2-3 times, acts on 1 minute, spontaneously dries.
4）The disinfection of mucosal sites：With this product 1:Mucosal sites to be sterilized are rinsed or are wiped in 1 dilution, act on 1 point
Clock spontaneously dries.
5）Wound is burnt and the skin degerming that festers：With this product 1:1 dilution rinses or wipes position to be sterilized, acts on
It 2-3 minutes, spontaneously dries.
The present invention is compared with other class properties of product：
Bactericidal effect of the present invention：
It is 100% to Escherichia coli sterilizing rate；
It is 100% to staphylococcus aureus sterilizing rate；
It is 100% to Candida albicans sterilizing rate；
It is 100% to gonococcal bactericidal rate.
Live sterilization test is 99.8% to body surface sterilizing rate, is more than the disinfection indicator of national regulation 90%.
Live sterilization test is 97.65% to palm surface disinfection rate, is more than the disinfection indicator of national regulation 90%.
The application of the present invention：
1）Skin, mucous membrane, hand disinfectant
Hand hygiene is closely bound up with everyone life, and about 80% common infectious disease is directly to be propagated by both hands, hand
Disinfection is clearly the most effective approach that disease preventing and treating is propagated.The product is sprayed directly on on hand as hand disinfectant, no matter when what
Ground all can safely, effectively, advantageously remove pathogenic bacteria on hand, be not required to water and soap, and can be colourless in one layer of formation on hand
Bright stealthy film keeps prolonged suppression, bactericidal effect.The product can effectively control typhoid fever influenza, dysentery, blood-shoot-eye illness, leaching
Sick and various dermopathic propagation, be suitble to restaurant, hotel, hospital, market, bank, school, kindergarten, family, office and
It uses during the journey.
2）It is home-use
The product has the various advantages such as nontoxic, colourless, odorless, corrosion-free, wide sterilization spectrum, is highly suitable for family disinfection.
It can be used for the sterilization cleaning of melon fruits and vegetables；Sterilization for each kind fabric such as clothing, towel, sheet is cleaned；And it is directly used in house
The sterilization of the body surfaces such as tool, carpet, sofa, kitchen utensils, sanitary ware and air.
3）Skin wound disinfectant
The product is colourless, non-corrosive, and effect is lasting, therefore can be conveniently used for the cleaning of skin, the surface of a wound, gynemetrics, urological department
Disinfection especially cannot use some the medical supplies of high-temperature sterilization, only need to be impregnated or be sprayed with the solution of 1 ‰ concentration, in short-term
It is interior to can reach satisfied bactericidal effect.The product can be additionally used in the disinfection of the air and wall, ground in ward.
4）Vulva washing lotion
Vulva washing lotion and suppository is made in the product, can be used for bacillary, mycotic, trichomonas, senile and non-specific vagina
The diseases such as inflammation, cervicitis, vulvitis, pudendal pruritus remove perineum peculiar smell, reduce secretion.Suitable for before and after men and women's sexual intercourse, go out
Equal pudendum cleanings disinfection, prevents the infection and propagation of skin disease, venereal disease before and after travel trip and gynecologic menstrual.It is suitable for hand simultaneously
The sterilized at the positions such as foot, anus.
5）Public place sterilization purification agent
In public places, a large amount of bacterium and viral infection disease seriously endanger the life security of the mankind, and sterilizing becomes
Safeguard the essential important link of people's life.The product has the characteristics that wide sterilization spectrum, nontoxic, colourless, odorless, and without appointing
What corrosivity, is highly suitable for the public places such as automobile, train, aircraft, steamer, market, hospital, cinema, hotel, restaurant
Sterilization.
6）Textile industry and sanitary napkin
The product can develop the textile of antimicrobial form, knitwear, as towel, underwear, infant-wear, bedding, wool are knitted
Object, gauze etc..Textile is immersed before the last arrangement stage in the special liquid of the product.When bacterium falls on the product treatment
When on the textile crossed, micro moisture makes active material dissolution that it contains, and kills bacterium rapidly, reach antibacterial, it is anti-insect,
Mould proof, shrink-proof, not hardened effect.Through overtesting, the textile of proper treatment, which is washed in water up to 120 times, still antibacterial
Property.
The product can easily develop all kinds of sterile and antibacterial sanitary napkin, panty liner, baby diapers etc., instead of adopting
With other traditional disinfection modes such as high temperature and ethylene oxide, cost is not only reduced, and it is effective to solve traditional disinfection mode
Phase short problem.Since the product can be linked uniformly with the slight fiber of said products, in one antiseptic of surface formation
Polymer foil can keep the optimum state after sterilization, while prevent secondary pollution.The performance of the product is extremely stable, effectively
Phase up to 2 years, makes the products such as the sanitary napkin produced keep permanent germ-free condition, keeps a public place clean to female private part and prevents gynaecology
Disease has apparent effect.
When producing sanitary napkin, panty liner, baby diaper, only sanitary napkin and urine pants need to be sprayed on the solution of 1 ‰ concentration
Surface, re-dry processing.
8）Tinea pedis, skin disease
The product is strong to the killing effect of fungi, and effect is lasting, therefore can be conveniently used for blister type, gruel caused by fungal infection
Tinea pedis, the ringworm of the foot such as rotten type, scales of skin that peel off keratinization type, decortication type；All kinds of fungi type skin diseases such as jock itch, favus of the scalp, ringworm of the body, the tinea manuum.And it rises
To the effect of antipruritic, putrefaction-removing granulation-promoting, recovery skin normal function.
9）Articles for washing
Articles for washing with sterilizing function in the market, generally all addition chlorinated product is disinfection composition, and exist has corruption to fabric
Corrosion, colour fading, the sterilization term of validity is short, is only used for the defects of white fabrics.And the product have be dissolved in water, nontoxic, colourless, nothing
It smells, is corrosion-free, is colour-fast, is non-stimulated to skin and mucosa, the superiority such as term of validity length, any colored fabrics of washing can be developed
The products such as high-tech environment-friendly type disinfecting washing powder, cleaning solution, dry cleaning agent.Sterilizing has become must in people's daily life
Indispensable important link, the appearance of the product, market prospects will be very broad.The product can not only kill on clothing
Various disease carrying germs prevent the propagation of venereal disease, and the clothing antibacterial and mouldproof significant effect after washing, are not yet developed to immune system
Perfect children are even more important, and play healthy protective effect.
Since the product has fungi extremely strong killing effect, therefore can be additionally used in shampoo, to removal dandruff and because
The ringworm of scalp caused by dandruff, seborrhea etc. have apparent sterilization, antipruritic effect.
10）Beverage and food-processing industry
The product is a kind of environmental type disinfectant, without harmful substances such as iodine, chlorine, aldehyde.The products application beer,
The sterilizing of the production facilities such as pipeline, container in beverage and food production and facility floor need to only dilute the product
25000 times（That is 10ppm）, impregnate or flushing pipe, you can reach bactericidal effect.If the filling food tank without particular/special requirement,
It can be improved completely using concentration to 250ppm, to achieve the effect that quick and complete killing bacterium.
11）Aquaculture
The product is a kind of high molecular polymer, can kill the Gram negative bacterium in seawater rapidly, float vibrios, secondary haemolysis arc
The harmful bacterias such as bacterium, vibrio alginolyticus, to sea cucumber and other aquatic products various diseases caused by bacterium have well prevent and
Therapeutic effect.
The product applies also for the diseases such as fishes and shrimps various red mouths caused by baculoviral, rotten eye, gill rot, the black gill, the yellow gill,
It can also be used to clear up shrimp ponds fish pond, feed waste, fish excrement etc. decomposed, the effect of purifying water, prevent sea cucumber, fish, shrimp illness.
The product is added in water circulating treatment procedure, can control algal grown, natural equilibrium sea cucumber pond, fishes and shrimps pond the ecosystem.
Claims (4)
1. a kind of skin and mucosa hand sanitizing fluid, which is characterized in that there is following material composition：
Poly hexamethylene biguanide 0.30 ~ 0.40% (w/v)
Acetic acid chlorhexidine 0.10 ~ 0.20% (w/v)
Water surplus.
2. a kind of skin and mucosa hand sanitizing fluid according to claim 1, which is characterized in that poly hexamethylene biguanide purity >=
99%。
3. a kind of skin and mucosa hand sanitizing fluid according to claim 1, which is characterized in that acetic acid chlorhexidine purity >=
97.5%。
4. a kind of skin and mucosa hand sanitizing fluid according to claim 1, which is characterized in that water is purified water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810245427.6A CN108324732A (en) | 2018-03-23 | 2018-03-23 | A kind of skin and mucosa hand sanitizing fluid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810245427.6A CN108324732A (en) | 2018-03-23 | 2018-03-23 | A kind of skin and mucosa hand sanitizing fluid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108324732A true CN108324732A (en) | 2018-07-27 |
Family
ID=62931363
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810245427.6A Pending CN108324732A (en) | 2018-03-23 | 2018-03-23 | A kind of skin and mucosa hand sanitizing fluid |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108324732A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111035674A (en) * | 2020-03-06 | 2020-04-21 | 吉林云飞医药有限公司 | Aner iodine skin mucosa disinfectant as well as preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101249268A (en) * | 2008-03-20 | 2008-08-27 | 中山一枝生物技术有限公司 | Disinfection sterilizing type medical supersonic couplant and method of preparing the same |
| CN105816339A (en) * | 2016-04-21 | 2016-08-03 | 江苏鱼跃信息系统有限公司 | Hand-washing-free disinfection solution and preparation method thereof |
-
2018
- 2018-03-23 CN CN201810245427.6A patent/CN108324732A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101249268A (en) * | 2008-03-20 | 2008-08-27 | 中山一枝生物技术有限公司 | Disinfection sterilizing type medical supersonic couplant and method of preparing the same |
| CN105816339A (en) * | 2016-04-21 | 2016-08-03 | 江苏鱼跃信息系统有限公司 | Hand-washing-free disinfection solution and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 崔玉杰等: "几种聚六亚甲基双胍复方消毒剂杀灭金黄色葡萄球菌效果比较", 《中国卫生检验杂志》 * |
| 崔玉杰等: "四种复方聚六亚甲基双胍消毒剂对白色念珠菌杀灭效果比较", 《中国消毒学杂志》 * |
| 崔玉杰等: "聚六亚甲基双胍与醋酸氯己定协同作用研究", 《医学动物防制》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111035674A (en) * | 2020-03-06 | 2020-04-21 | 吉林云飞医药有限公司 | Aner iodine skin mucosa disinfectant as well as preparation method and application thereof |
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| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20180727 |
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| WD01 | Invention patent application deemed withdrawn after publication |