CN115364170A

CN115364170A - Sugar metabolism regulator and preparation method and application thereof

Info

Publication number: CN115364170A
Application number: CN202211289183.4A
Authority: CN
Inventors: 韩妮萍; 程永现; 卞瑶; 吴月滢; 袁嘉丽; 羊忠山; 管琦
Original assignee: Yunnan University of Traditional Chinese Medicine TCM
Current assignee: Yunnan University of Traditional Chinese Medicine TCM
Priority date: 2022-10-20
Filing date: 2022-10-20
Publication date: 2022-11-22
Anticipated expiration: 2042-10-20
Also published as: CN115364170B

Abstract

The invention belongs to the technical field of diabetes prevention and treatment, and particularly relates to a glucose metabolism regulator and a preparation method and application thereof, wherein the glucose metabolism regulator is prepared by weighing 5-10 parts by weight of Chinese yam, 5-10 parts by weight of black fungus, 3-6 parts by weight of gardenia, 3-6 parts by weight of kudzu root, 3-6 parts by weight of wine-roasted rhizoma polygonati, 3-6 parts by weight of mulberry leaf, 1-2 parts by weight of Pu' er ripe tea and 1-2 parts by weight of cinnamon, carrying out water extraction, alcohol precipitation, reflux extraction, filtration, reduced pressure distillation on filtrate to remove ethanol, concentrating refined solution, freeze drying or spray drying, and crushing; can be prepared into oral preparations such as capsules, granules, tablets, powder, pills or oral liquid by a conventional forming method, and can be used for preparing medicines for treating type 2 diabetes or health-care products for improving glycometabolism disorder. The regulator is composed of medicinal and edible materials, has the effects of invigorating spleen, benefiting stomach, clearing heat, promoting fluid production, nourishing yin, promoting blood circulation, invigorating kidney, tonifying yang, regulating blood sugar, and improving sugar metabolism disorder.

Description

Sugar metabolism regulator and preparation method and application thereof

Technical Field

The invention belongs to the technical field of diabetes prevention and treatment, and particularly relates to a glucose metabolism regulator and a preparation method and application thereof.

Background

Diabetes is a chronic metabolic disease characterized primarily by hyperglycemia. Its pathogenesis is generally considered to be related to insulin hyposecretion and/or islet resistance. Diabetes is mainly divided into type 1 diabetes, type 2 diabetes and other types of diabetes, wherein type 2 diabetes accounts for more than 95% of patients. Abnormal carbohydrate metabolism is one of the typical pathological manifestations of diabetes. China is one of the countries with the highest prevalence rate of diabetes, the total number of people suffering from diabetes reaches 9240 thousands, and diabetes also becomes one of the diseases seriously harming the health of people in China following tumors and cardiovascular diseases.

Chinese patent application No. 202110854135.4 discloses a Chinese medicinal composition for treating type 2 diabetes and a preparation method thereof, wherein the Chinese patent application No. 202110854135.4 comprises the following components in parts by weight: 1-10 parts of radix salviae miltiorrhizae, 5-10 parts of mulberry leaves, 5-10 parts of kudzu roots, 1-10 parts of pearl barley and 1-10 parts of Chinese yam. Adding 7.5 times of water, decocting for 45min, extracting, filtering, concentrating the filtrate to relative density of 1.25-1.35 and 80 deg.C to obtain water extract; adding 2 times of ethanol into the above water extract, precipitating with ethanol at 4 deg.C for 12 hr, filtering, distilling the filtrate under reduced pressure to remove ethanol, concentrating into soft extract, vacuum freeze drying, and pulverizing. The traditional Chinese medicine composition can obviously reduce the fasting blood glucose value of a type 2 diabetic mouse, has good blood glucose reduction effect and good effect of improving type 2 diabetes, and can obviously improve the insulin resistance index and the pancreatic mitochondria function.

Chinese patent application No. 201510157103.3 discloses a Chinese medicine for treating type II diabetes and a preparation method thereof, wherein the Chinese medicine composition comprises the following components in parts by mass: the paint comprises the following components in parts by weight: 3-5 parts of cordyceps militaris, 10-12 parts of erigeron breviscapus, 7-9 parts of semen coicis, 7-9 parts of rhodiola rosea, 5-7 parts of dendrobium, 7-9 parts of honeysuckle, 3-5 parts of ginkgo, 5-7 parts of moringa leaves, 3-5 parts of Auricularia, 3-5 parts of radix puerariae, 4-6 parts of eucommia ulmoides, 4-6 parts of ginkgo, 3-5 parts of gardenia roots, 5-7 parts of codonopsis pilosula and 10-12 parts of yacon. The traditional Chinese medicine provided by the invention has the effects of promoting the production of body fluid to quench thirst and clearing away heat and toxic materials, can be used for remarkably reducing the blood sugar of a diabetic patient of type II, is stable in a normal range, has the effect of improving the renal function, can be taken for a long time, and has no toxic or side effect.

Chinese patent application No. 202010339223.6 discloses a Chinese medicinal composition for treating type 2 diabetes, which comprises the following raw materials: wild potentilla discolor, wild cogongrass rhizome, wild lygodium japonicum root, ginseng leaf (more than 7 years), wild filigree, wild cercis chinensis, winter mulberry leaf, green tea, wild agaric, corn stigma and dandelion root. The traditional Chinese medicine composition is suitable for patients with type 2 diabetes and type 2 diabetes complications, has no adverse reaction and has stable curative effect.

Chinese patent application No. 201510849003.7 discloses a Chinese medicinal composition for treating type II diabetes mellitus with homology of medicine and food, which is characterized by comprising the following components in part by weight: 30g of wheat seedlings, 25g of taros, 20g of watermelon peel, 20g of purslane, 25g of endive, 15g of endothelium corneum gigeriae galli and 10g of pig pancreas. The invention has the functions of soothing liver, tonifying kidney, promoting blood circulation, removing blood stasis, dredging channels and collaterals, regulating qi activity, invigorating spleen, tonifying qi, purging fire, expelling toxin, strengthening body resistance and consolidating the constitution, and the pancreatic functions can be recovered by combining the medicines.

The medicine and food homologous treatment of diabetes is always a hotspot of current research, and the problem of how to furthest improve the effectiveness and the palatability of the medicine and food homologous treatment is urgently needed to be solved. The traditional Chinese medicine food homology formula for treating diabetes in the prior patent has the defects of single medicine, single applicability and poor palatability, and the traditional Chinese medicine food homology formula has an improvement effect on diabetes of various symptoms on the basis of traditional Chinese medicine dialectics, such as spleen deficiency phlegm-dampness syndrome, yin and yang deficiency syndrome, lung heat and body fluid deficiency syndrome, stomach heat excess syndrome, qi and yin deficiency syndrome, kidney yin deficiency syndrome and the like; the invention adds the products with good palatability such as yam, black fungus, kudzuvine root, cinnamon, pu' er ripe tea and the like which are homologous in medicine and food, is a good choice as powder, decoction, paste or health food, and has good market prospect.

The action mechanism of the traditional Chinese medicine has the characteristics of multiple targets, multiple components and high synergy. Research and development of related products of functional foods of traditional Chinese medicines are also in the way of being in the vogue, and therefore, homology of medicine and food becomes an important part on the modernization road of traditional Chinese medicines, so that a glucose metabolism regulator can be developed based on the treatment characteristics of homology of medicine and food and multiple targets in traditional Chinese medicines.

Disclosure of Invention

In order to solve the technical problems, the invention provides a glucose metabolism regulator, a preparation method and application thereof, which are used for improving or treating type 2 diabetes.

In order to achieve the purpose, the invention adopts the following specific technical scheme:

a sugar metabolism regulator comprises the following components in parts by weight: 5-10 parts of Chinese yam, 5-10 parts of black fungus, 3-6 parts of cape jasmine, 3-6 parts of kudzu root, 3-6 parts of wine-fried rhizoma polygonati, 3-6 parts of mulberry leaf, 1-2 parts of Pu' er ripe tea and 1-2 parts of cinnamon.

Preferably, the sugar metabolism regulator comprises the following components in parts by weight: 10 parts of Chinese yam, 10 parts of black fungus, 6 parts of cape jasmine, 6 parts of kudzu root, 6 parts of wine-roasted rhizoma polygonati, 6 parts of mulberry leaf, 2 parts of Pu-erh ripe tea and 2 parts of cinnamon.

Preferably, the rhizoma polygonati is polygonatum kingianum.

Preferably, the mulberry leaves are frost mulberry leaves.

The invention also provides a preparation method of the sugar metabolism regulator, which comprises the following steps:

s1, material preparation: weighing the components in parts by weight;

s2, water extraction: decocting in water 8-10 times for 20-40min for 2-3 times, filtering, and mixing filtrates;

s3, alcohol precipitation: concentrating under reduced pressure to density of 1.06-1.07g/mL, adding 1.5-3 times of anhydrous ethanol, precipitating with ethanol for 24-48 hr, reflux extracting for 1.5-2 hr, filtering, and distilling the filtrate under reduced pressure to remove ethanol to obtain refined solution;

s4, drying: concentrating the refined solution, vacuum freeze drying or spray drying, and pulverizing to obtain sugar metabolism regulator.

Preferably, the S2 is extracted with water: decocting in 10 times of water for 30min, decocting for 2 times, filtering, and mixing filtrates.

Preferably, the S3 alcohol precipitation: concentrating under reduced pressure to density of 1.066g/mL, adding 2 times of anhydrous ethanol, precipitating with ethanol for 24-48 hr, reflux extracting for 1.5 hr, filtering, and distilling the filtrate under reduced pressure to remove ethanol to obtain refined solution.

Further, the sugar metabolism regulator is prepared into oral preparations such as capsules, granules, tablets, powder or pills through a conventional forming process, so that the product is more convenient to store, transport, popularize and apply.

The glucose metabolism regulator can be used for preparing medicines for treating type 2 diabetes and health products for improving glucose metabolism disorder.

In the formula of the glucose metabolism regulator, the Chinese yam has the effects of supplementing qi, nourishing yin, and tonifying spleen, lung and kidney; the black fungus has the effects of clearing away lung-heat, moistening intestines, nourishing yin, replenishing blood, promoting blood circulation and removing blood stasis; radix Puerariae has effects of relieving muscles and fever, promoting eruption, promoting fluid production to quench thirst, invigorating yang and relieving diarrhea, and dredging meridian passage; cape jasmine has the effects of purging fire, relieving restlessness, clearing heat, promoting diuresis, cooling blood and removing toxicity; the wine-roasted polygonatum kingianum has the effects of tonifying spleen, moistening lung, tonifying qi and yin and essence and blood; frosted mulberry leaves, wind heat dissipation, lung heat dryness, eye disease treatment, blood cooling, thirst quenching and sweat stopping; the Pu-Er ripe tea has the effects of clearing heat, promoting diuresis, promoting digestion and refreshing mind; cinnamon has the effects of tonifying fire, supporting yang, dispelling cold, relieving pain, warming channels, dredging collaterals and guiding fire to origin. Has the functions of invigorating spleen and stomach, clearing heat and promoting fluid production, nourishing yin and activating blood, tonifying kidney and strengthening yang.

According to modern pharmacological research, the method comprises the following steps: the yam polysaccharide has better glycolipid regulation effect, and the action mechanism of the yam polysaccharide is probably related to the improvement of insulin sensitivity and antioxidation; the black fungus exopolysaccharide has obvious effect of regulating blood sugar, can promote the proliferation of beneficial flora in intestinal tracts, increase the content of short-chain fatty acid and up-regulate the level of serum anti-inflammatory factors; puerarin in radix Puerariae can reduce insulin resistance of type 2 diabetic mice by regulating Fetuin B (Fetuin B) -adenylate activated protein kinase (AMPK)/acetyl coenzyme A carboxylase (ACC) signal pathway of liver, and further improve glycolipid metabolism; the gardenia aqueous extract has obvious curative effects on reducing serum insulin and improving insulin sensitivity index; rhizoma Polygonati (processed with wine) can effectively improve glycolipid metabolism disorder state of rat fed with high fat diet, preferably rhizoma Polygonati Yunnanensis; the mulberry leaf polysaccharide has the effects of reducing blood sugar, regulating insulin signal paths and inhibiting alpha-glycosidase, and the mulberry leaves are preferably frosted mulberry leaves; the Pu-Er ripe tea tablet as the Pu-Er ripe tea standard extract can reduce the fasting blood glucose level of the diabetic; cinnamon can reduce blood sugar of db/db mice, improve inflammatory response of the mice and increase the content of Short Chain Fatty Acids (SCFAs) so as to achieve the effect of preventing and treating type 2 diabetes. According to network pharmacological analysis, the core components of the 8-component edible and Chinese medicine are diosgenin, kadsura pepper stem ketone, quercetin, kaempferol, sterol, quercetin, beta-sitosterol, daidzein, puerarin and procyanidine beta 1. The core targets are protein kinase (AKT 1), nuclear receptor subfamily 3C group member 1 (NR 3C 1), V-REL reticuloendotheliosis virus oncogene homolog A (RELA), inducible nitric oxide synthase (NOS 2), serum amyloid A1 (SAA 1), cyclooxygenase 2 (PTGS 2), interleukin-6 (IL-6), tumor Necrosis Factor (TNF), glycogen synthase kinase 3 beta (GSK 3B), caspase 3 (CASP 3), albumin (ALB), catalase (CAT), androgen Receptor (AR), human Insulin (INS) and human Vascular Endothelial Growth Factor A (VEGFA). The main pathways enriched by the KEGG pathway are hypoxia inducible factor 1 (HIF 1) signaling pathway, cancer pathway, regulation of lipolysis in adipocytes, vascular endothelial growth factor signaling pathway, intracellular phosphatidylinositol kinase (PI 3K) -protein kinase (Akt) signaling pathway, insulin resistance, tumor necrosis factor-alpha (TNF) signaling pathway, AMPK signaling pathway, insulin signaling pathway AGE-RAGE signaling pathway, interleukin-17 (IL-17) signaling pathway, and the like. The eight medicinal materials are medicinal and edible products, have the function of regulating blood sugar according to modern pharmacological research, and effectively improve the glucose metabolism disorder of the type 2 diabetes at multiple targets.

The beneficial effects of the invention include: the glucose metabolism regulator has the functions of invigorating spleen and stomach, clearing heat and promoting fluid production, nourishing yin and activating blood circulation, tonifying kidney and supporting yang, is prepared from medicinal and edible materials, is based on the treatment principle and treatment method of diabetes in traditional Chinese medicine, is combined with the modern pharmacological research basis, can regulate blood sugar at multiple targets, obviously improves glucose metabolism disorder, has no toxic or side effect, is simple in preparation method, easy to carry and take, and can realize industrial large-scale preparation.

Drawings

FIG. 1 is a schematic diagram of statistics of glucose metabolism regulator intervention type 2 diabetes mellitus (T2 DM) mouse insulin tolerance determination and insulin resistance index calculation results.

Detailed Description

The technical scheme of the invention is clearly and completely described below by combining the embodiment of the invention.

Example 1

Weighing 7 parts of Chinese yam, 7 parts of black fungus, 4 parts of cape jasmine, 4 parts of kudzu root, 4 parts of wine-roasted rhizoma polygonati, 4 parts of mulberry leaf, 1 part of Pu' er ripe tea and 1 part of cinnamon, adding 8 times of water, decocting for 20min, decocting for 3 times, filtering, combining the filtrates, concentrating under reduced pressure until the density is 1.061g/mL, adding 1.5 times of absolute ethyl alcohol, precipitating with ethanol for 24 hours, carrying out reflux extraction in a water bath at 80 ℃ for 1.5 hours, filtering, distilling the filtrate under reduced pressure to remove the ethyl alcohol to obtain a refined liquid, concentrating the refined liquid, freeze-drying, and crushing to obtain the sugar metabolism regulator.

Example 2

Weighing 10 parts of Chinese yam, 10 parts of black fungus, 6 parts of cape jasmine, 6 parts of kudzu root, 6 parts of Yunnan sealwort after wine roasting, 6 parts of frosted mulberry leaf, 2 parts of Pu' er ripe tea and 2 parts of cinnamon, adding 10 times of water, decocting for 30min, decocting for 2 times, filtering, combining filtrates, concentrating under reduced pressure until the density is 1.066g/mL, adding 2 times of absolute ethyl alcohol, precipitating with ethanol for 48h, heating and refluxing for extracting for 1.5h, filtering, distilling the filtrate under reduced pressure to remove the ethanol to obtain a refined liquid, concentrating the refined liquid, spray-drying and crushing to obtain the sugar metabolism regulator.

Example 3

Weighing 10 parts of Chinese yam, 10 parts of black fungus, 6 parts of cape jasmine, 6 parts of kudzu root, 6 parts of Yunnan sealwort after wine roasting, 6 parts of frosted mulberry leaf, 2 parts of Pu' er ripe tea and 2 parts of cinnamon, adding 10 times of water, decocting for 30min, decocting for 2 times, filtering, combining filtrates, concentrating under reduced pressure until the density is 1.066g/mL, adding 2 times of absolute ethyl alcohol, precipitating with ethanol for 48h, heating and refluxing for extracting for 1.5h, filtering, distilling the filtrate under reduced pressure to remove the ethanol to obtain a refined liquid, concentrating the refined liquid, freeze-drying and crushing to obtain the sugar metabolism regulator.

Example 4

Weighing 5 parts of Chinese yam, 5 parts of black fungus, 3 parts of cape jasmine, 3 parts of kudzu root, 3 parts of wine-roasted rhizoma polygonati, 3 parts of mulberry leaf, 1 part of Pu' er ripe tea and 1 part of cinnamon, adding 10 times of water, decocting for 40min, decocting for 2 times, filtering, combining filtrates, concentrating under reduced pressure until the density is 1.07g/mL, adding 3 times of absolute ethyl alcohol, precipitating with ethanol for 48h, extracting in 80 ℃ water bath under reflux for 2h, filtering, distilling the filtrate under reduced pressure to remove the ethanol, obtaining refined liquid, concentrating, vacuum freeze-drying and crushing to obtain the sugar metabolism regulator.

Examples of the experiments

In this experiment, the sugar metabolism regulator obtained in example 2 was used as a drug sample, and metformin was used as a control sample, and the study of the action mechanism of the sugar metabolism regulator of the present invention was specifically carried out by the following procedure.

(1) Construction of type 2 diabetes mouse model

60C 57/BL6 male mice (Duoduoda laboratory animals Co., ltd.) were adaptively raised for 1 week, then fed with high fat diet [ 60 kCal fat Research Diets D12492 x 12.5kg ] (purchased from Duoduoda Shang Fei g Biotechnology Co., ltd.) for 6 weeks, fasted without water deprivation for 12 hours, mice were induced to type 2 diabetes by a single 100mg/kg intraperitoneal injection of Streptozotocin (STZ), and after induction for one week, fasting blood glucose was measured with a Trinoglucose meter; mice with fasting blood glucose value of more than or equal to 11.1mmoL/L for 2 days continuously determine that the 2-type diabetes mouse model is successfully prepared.

(2) Group administration to animals

Randomly divided into 6 groups according to blood glucose: blank group, model group, dosing group: low dose group, medium dose group, high dose group, control group: the metformin group. Based on the conversion formula of the body surface areas of human and mouse (average body weight of human being is about 70kg, recorded human dose is X mg/kg, mouse dose = X mg/kg × 70kg × 0.0026/24g =Xmg/kg × 70kg × 0.0026/0.024kg =7.59 × X mg/kg), which are converted to 1/2 times, 1 time and 2 times of the clinically equivalent dose, the dosages of crude drugs for low, medium and high dosages are calculated to be 3g/kg/d, 6g/kg/d and 12g/kg/d, and on this basis, the dosages of crude drugs are multiplied by the equivalent of the sugar metabolism-regulating agent prepared in example 2 to obtain the administration dosages for low, medium and high dosages. And (3) dissolving the mixture by using a proper amount of normal saline, then performing intragastric administration, dissolving the mixture by using the normal saline with the same volume in a dosage of 0.25g/kg/d in the metformin group, then performing intragastric administration, and performing intragastric administration for 6 weeks by using the normal saline with the same volume in the blank group and the model group every day. And (4) normally feeding the mice of each corresponding group by using basic feed and high-fat feed until the experiment is finished.

(3) Fasting blood glucose test

After the experiment is started, the blood glucose values of mice in each group are detected for l2h on empty stomach after administration once at the same time every day for 6 weeks, and the detection results are shown in table 1.

In Table 1, model groups are compared to blank groups, ^## P<0.01; each administration group and metformin group were compared with the model group, ^** P<0.01。

as shown in Table 1, each group of the traditional Chinese medicine composition can obviously reduce the fasting blood glucose value of the type 2 diabetes mouse, so that the glucose metabolism regulator disclosed by the invention has a good glucose reducing effect and can be used for regulating glucose metabolism disorder of the type 2 diabetes mouse.

(4) Sugar tolerance test

At the end of 6 weeks of the experiment, after fasting the mice for 12h, the mice were gavaged with 2g/kg of 20% glucose (2 g glucose per lkg weight mice); the blood glucose content was measured with a Sanno glucometer at 30, 60, 90 and 120min after fasting and ingestion of sugar, respectively, and the test results are shown in Table 2.

Table 2 table of results of sugar tolerance test

In Table 2, the model groups were compared with the blank group, ^## P<0.01; each administration group and metformin group were compared with the model group, ^** P<0.01。

as shown in table 2, the administered group showed an equivalent effect to the metformin group, and significantly decreased the blood glucose level in the model mice, thereby demonstrating that the glucose metabolism-regulating agent of the present invention has a good effect of improving impaired glucose tolerance in type 2 diabetes.

(5) Insulin tolerance measurement and calculation of insulin resistance index (HOMA-IR)

After the mice are subjected to intragastric administration for 6 weeks, fasting and no water supply is performed for 12 hours, tail breaking is performed quickly, blood sampling is performed to measure fasting blood glucose, the fasting blood glucose is recorded as 0min blood glucose, insulin with concentration (0.5 IU/10g body mass) is prepared, blood glucose values are detected respectively 30min, 60min, 90min and 120min after injection through intraperitoneal injection, and blood glucose broken line graphs are recorded and drawn to calculate AUC areas; enzyme-linked immunosorbent assay (Elisa assay) mice fasting insulin levels, combined with experimental mice fasting blood glucose, were measured and calculated HOMA-IR values according to the following calculation:

the measurement results are shown in tables 3-6, the related data in tables 3-6 are visualized and drawn into a schematic diagram, and the results are shown in FIG. 1.

In fig. 1, NC represents the blank group, DC represents the model group, HSZ represents the high dose group, MSZ represents the medium dose group, LSZ represents the low dose group, and DME represents the metformin group.

TABLE 3 insulin glucose tolerance test (ITT) test results Table

In Table 3, the model groups were compared with the blank group, ^## P<0.01; each administration group and metformin group were compared with the model group, ^** P<0.01。

TABLE 4 calculation result table of insulin glucose tolerance test peak area (ITT AUC)

In Table 4, the model groups were compared with the blank group, ^*** P<0.001; each administration group and metformin group were compared with the model group, ^### P<0.001。

TABLE 5 serum fasting Insulin (INS) assay results Table

In Table 5, fasting insulin secretion tended to decrease in the model group compared to the blank group; compared with the model group, the fasting insulin secretion of each administration group and metformin group tended to increase.

TABLE 6 Table for the results of calculation of insulin resistance index (HOMA-IR)

In Table 6, the model groups were compared with the blank group, ^*** P<0.001; each administration group and metformin group were compared with the model group, ^### P<0.001， ^## P<0.01。

as shown in tables 3-6, and in fig. 1: the insulin glucose tolerance test (ITT) further evaluates the improvement condition of the glucose metabolism regulator on the insulin resistance and the pancreatic islet function of an experimental mouse, and compared with a model group, the area under the concentration-time curve (AUC) of an administration group subjected to the sugar metabolism regulator drying is obviously reduced, and the reduction effect is equivalent to that of a metformin group; the serum insulin levels of the mice in each group were measured to find that: the administration group can improve the insulin secretion level of the T2DM mice, combine with the fasting blood glucose of the experimental mice, and calculate the HOMA-IR value according to the steady-state model HOMA-IR formula, and the result shows that the HOMA-IR of the T2DM mice is increased, the administration group is reduced, and the reduction effect is equivalent to that of the metformin group.

In conclusion, according to the experimental conclusion of the experimental example, the glucose metabolism regulator disclosed by the invention can regulate blood sugar and obviously improve glucose metabolism disorder.

It is expected that the glucose metabolism regulator obtained in the above examples 1 to 4 is prepared into an oral preparation of capsules, granules, tablets, powders, pills or oral liquids by a conventional molding method, so that the glucose metabolism regulator of the present invention is more convenient to store, transport, popularize and apply, and can be used for preparing a medicament for treating type 2 diabetes or a health care product for improving glucose metabolism disorder.

The above description is only for the purpose of illustrating the preferred embodiments of the present invention and should not be taken as limiting the scope of the present invention, which is intended to cover any modifications, equivalents, improvements, etc. within the spirit and scope of the present invention.

Claims

1. The sugar metabolism regulator is characterized by comprising the following components in parts by weight: 5-10 parts of Chinese yam, 5-10 parts of black fungus, 3-6 parts of cape jasmine fruit, 3-6 parts of kudzu root, 3-6 parts of wine-fried rhizoma polygonati, 3-6 parts of mulberry leaf, 1-2 parts of Pu-erh ripe tea and 1-2 parts of cinnamon.

2. The sugar metabolism regulator according to claim 1, comprising the following components in parts by weight: 10 parts of Chinese yam, 10 parts of black fungus, 6 parts of cape jasmine, 6 parts of kudzu root, 6 parts of wine-roasted rhizoma polygonati, 6 parts of mulberry leaf, 2 parts of Pu-erh ripe tea and 2 parts of cinnamon.

3. A sugar metabolism regulator according to claim 1, wherein: the rhizoma Polygonati is Polygonatum kingianum.

4. A sugar metabolism regulator according to claim 3, wherein: the folium Mori is frost folium Mori.

5. A method for preparing a sugar metabolism regulator, comprising the steps of:

s1, material preparation: weighing the components according to the parts by weight of any one of claims 1 to 4;

6. The method for preparing a sugar metabolism regulator according to claim 5, wherein the S2 water extraction: decocting in 10 times of water for 30min, decocting for 2 times, filtering, and mixing filtrates.

7. The method for preparing a sugar metabolism regulator according to claim 5, wherein the S3 alcohol is precipitated: concentrating under reduced pressure to density of 1.066g/mL, adding 2 times of anhydrous ethanol, precipitating with ethanol for 24-48 hr, reflux extracting for 1.5 hr, filtering, and distilling the filtrate under reduced pressure to remove ethanol to obtain refined solution.

8. The method for producing a sugar metabolism regulator according to claim 5, wherein: the sugar metabolism regulator is prepared into oral preparations such as capsules, granules, tablets, powder, pills or oral liquid by a conventional forming process.

9. Use of a modulator of sugar metabolism according to any one of claims 1 to 4 in the manufacture of a medicament for the treatment of type 2 diabetes.

10. Use of the sugar metabolism regulator according to any one of claims 1 to 4 for the preparation of a health product for improving disorders of sugar metabolism.