CN115363982B - Modified silicon powder prepared by supergravity acceleration process and application thereof - Google Patents

Modified silicon powder prepared by supergravity acceleration process and application thereof Download PDF

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Publication number
CN115363982B
CN115363982B CN202111527372.6A CN202111527372A CN115363982B CN 115363982 B CN115363982 B CN 115363982B CN 202111527372 A CN202111527372 A CN 202111527372A CN 115363982 B CN115363982 B CN 115363982B
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silicon powder
modified silicon
ceramide
liposome
skin
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CN115363982A (en
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黄旭敏
荣迪
郎鹏
陈国燕
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Guangzhou Hua Chu Xian Biotech Co ltd
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Guangzhou Hua Chu Xian Biotech Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
    • A61K8/585—Organosilicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25—Silicon; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A61K8/553—Phospholipids, e.g. lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95

Abstract

The invention relates to the technical field of IPC A61K, in particular to modified silicon powder prepared by a hypergravity acceleration process and application thereof. The preparation process of the modified silicon powder comprises the following steps: s1, preparing liposome; s2, mixing the liposome, the siloxane compound and the silicon powder in a hypergravity rotating bed to obtain a modified silicon powder finished product. The liposome is grafted on the surface of the silicon powder by adopting a supergravity acceleration process, so that the modified silicon powder which has unique smooth skin feel, light and thin texture and is easy to spread is obtained, and the formula stability is strong when the modified silicon powder is applied to cosmetics; meanwhile, the specific flooding gas is adopted to act on the materials, so that the molecular binding force among the raw materials and the formation of a powder microstructure are promoted, the obtained modified silicon powder is small in particle size and narrow in distribution, can effectively fill skin fine lines and blur skin flaws, has extremely strong hydrophobic characteristics, can adsorb grease on the surface layer of the skin, can control makeup for a long time and can realize the effects of moisturizing and nourishing the skin.

Description

Modified silicon powder prepared by supergravity acceleration process and application thereof
Technical Field
The invention relates to the technical field of IPC A61K, in particular to modified silicon powder prepared by a hypergravity acceleration process and application thereof.
Background
With the improvement of the quality of life and the acceleration of the work rhythm of people, consumers have put higher demands on the performance of cosmetics. Silica powder is used as porous spherical inorganic material, can absorb grease secreted by skin, and is a popular raw material for oil control products. However, when the silicon powder is added into cosmetics and directly applied to skin, the silicon powder is difficult to spread, the skin affinity is poor, the phenomena of powder flying and false white are easy to occur, and the use experience is poor. The ceramide is taken as a high moisturizing factor, is extremely difficult to be dissolved by a solvent when being applied to cosmetics, can be micro-compatible only by means of a strong polar solvent, has poor compatibility in a formula, and cannot fully exert moisturizing and skin care effects.
Chinese patent CN103565673a discloses a skin moisturizing lotion for moisturizing skin and controlling oil and a preparation method thereof, which adopts hydrogenated lecithin, silica and ceramide to achieve the effects of efficiently moisturizing skin and improving the problem of skin dryness. Chinese patent CN111329780a discloses a tightening and light-grain moisturizing repair face cream and a preparation method thereof, which adopts the functions of hydrogenated lecithin, amino acid complex liquid, skin conditioner and the like to achieve the moisturizing repair function. Chinese patent CN109330927A discloses a moisturizing and repairing cream and a preparation method thereof, and the moisturizing and repairing cream has the effects of moisturizing and repairing skin color and brightening skin through the effects of cyclomethicone, G-162 silicone elastomer, water-soluble ceramide and the like. However, these prior arts are only limited in the level of adding a large amount of functional components to enhance the skin care effect, and do not fundamentally solve the problems of low absorption and utilization rate of the skin to the active ingredients, and have the limitations of high cost and limited efficacy enhancement.
Disclosure of Invention
In order to solve the problems, the first aspect of the invention provides modified silicon powder prepared by a super-gravity acceleration process. The preparation process of the modified silicon powder comprises the following steps:
s1, preparing liposome;
s2, mixing the liposome, the siloxane compound and the silicon powder in a hypergravity rotating bed to obtain a modified silicon powder finished product.
Silica flour is as the powder that the surface is rich in the hole, can effectively absorb skin grease, but the in-process of practical application in cosmetics, inorganic powder is easy to gather in the application process, and smoothness is lower, and the use experience is very poor. The applicant finds that the silicon powder and the liposome can be combined by adopting a supergravity acceleration process, the fineness and smoothness of the silicon powder are optimized, and meanwhile, the liposome carried by the silicon powder can promote the combination capability of active components and skin, so that the silky skin pasting effect is realized.
In some preferred embodiments, the liposome preparation raw materials comprise a wrapper and a wrapper carrier, and the weight ratio of the wrapper to the wrapper carrier is 1: (1-10).
In some preferred embodiments, the step S1 specifically includes: adding the wrapper and the wrapping carrier into the oiling agent, and heating and uniformly stirring to obtain a phase A; water and polyhydroxy compound are mixed according to the mass ratio of 1: (6-14) mixing to obtain phase B; mixing the materials of phase A and phase B, transferring to a high-pressure micro-jet homogenizer, homogenizing under 100-200MPa for 2-30min to obtain liposome final product.
In some preferred embodiments, the step S2 specifically comprises mixing liposome, silicone compound and silicon powder according to a weight ratio of (1-15): (0.2-6): 100, adding water with the mass of 30-60 times that of the silicon powder, and uniformly stirring to obtain a mixture; introducing the mixture into a super gravity rotating bed at a flow rate of 10-50g/min at 70-80deg.C, and at the same time at 1-3m 3 Introducing flooding gas into the flow of/h, reacting for 15-30min under the condition of 800-6000rpm, filtering, and drying to obtain the modified silicon powder finished product.
In some preferred embodiments, the silicon powder has a Mohs hardness of 3 to 10 and a thermal conductivity of 0.5 to 2W/K.M.
Further preferably, the boiling point of the flooding gas is-200 to-30 ℃.
Still more preferably, the flooding gas is nitrogen and/or carbon dioxide.
The boiling point of the nitrogen is-196 ℃, and the boiling point of the carbon dioxide is-78.5 ℃.
In some preferred embodiments, the wrap is a ceramide; the ceramide comprises one or more combinations of ceramide EOS, ceramide NP, ceramide EOH, ceramide AS, caproyl sphingosine, ceramide AH, ceramide NH, ceramide EOP, cetyl-PG hydroxyethyl palmitamide.
Further preferably, the CERAMIDE is preferably CERAMIDE NP (CERAMIDE 3).
In some preferred embodiments, the encapsulation carrier comprises a combination of one or more of hydrogenated lecithin, phosphatidylcholine, diphosphatidylglycerol, phosphatidylinositol, tricetyl phosphate; hydrogenated lecithin is preferred.
In some preferred embodiments, the silicone compound comprises one or more of n-octyltriethoxysilane, trimethoxysilane, triethoxysilane, isobutyltriethoxysilane, dimethyldiethoxysilane, polydimethylsiloxane, cyclomethicone, polymethylphenylsiloxane, polyether polysiloxane copolymer, aminosilicone.
Further preferably, the silicone compound is n-octyltriethoxysilane and polydimethylsiloxane; the weight ratio of n-octyl triethoxysilane to polydimethylsiloxane is 1: (0.5-3).
In some preferred embodiments, the oil comprises animal oil and/or vegetable oil.
Further preferably, the oil agent is a vegetable oil.
Examples of vegetable oils include, but are not limited to, perilla seed oil, calendula oil, tea tree oil, coix seed oil, sea buckthorn oil. In order to improve the interfacial compatibility of the liposome and the silicon powder, the plant oil is calendula oil and tea tree oil, and the weight ratio of the calendula oil to the tea tree oil is 1 (2-6).
In some preferred embodiments, the polyol has a functionality of 1 to 5, a melting point of 5 to 30℃and a surface tension of 30 to 72dyne/cm.
Further preferably, the polyol has a functionality of 3, a melting point of 18.2℃and a surface tension of 61.9dyne/cm, i.e.the polyol is glycerol.
The invention combines ceramide and phospholipid membrane structure by innovative lipid encapsulation technology; in the research process, the ceramide NP is mixed with hydrogenated lecithin, and the mixture acts under the condition of high-pressure microjet, particularly the mixture is homogenized for 2-30min under the condition of 100-200MPa, so that the technical problem that the ceramide NP is difficult to add in skin care products and color cosmetic formulas and has poor bonding capability with silica can be solved; the hydrogenated lecithin wraps the ceramide NP, the ceramide NP is grafted to the surface of silica under the cooperation of a siloxane compound, the silica carries liposome to reach skin pores, long linear phospholipid molecules soften the skin cuticle, the penetrability of the ceramide NP on the skin surface layer is rapidly improved, the ceramide NP reaches the cuticle to play a role in balancing water and oil, the secretion of skin grease is effectively inhibited, and the skin nourishing effect is realized.
Further research shows that the inlet flow of the mixture and the rotating speed of the hypergravity rotating bed in the hypergravity acceleration treatment process have important influence on the contact and combination between the composite material phase and the phase, and further influence the structure and the performance of the modified silicon powder. It was unexpectedly found that when the mixture was controlled to pass into a super gravity rotating bed at a flow rate of 10-50g/min, at the same time 1-3m 3 When flooding gas with the boiling point of-200 to-30 ℃ is introduced into the flow of/h, the mass transfer resistance can be reduced to the greatest extent by matching with the rotating speed effect of 800-6000rpm, and the liposome-silicon powder is promoted to be rapidly diffused in a hypergravity environment, so that modified powder with small particle size, narrow distribution and uniform morphology is formed; simultaneously, the weight ratio is 1: (0.5-3) n-octyl triethoxysilane and polydimethylsiloxane, can firmly bond liposome and spherical silica powder, neutralize the charge on the surface of crystal nucleus while forming an intermediate crystal boundary layer, compress the space of an intermediate region, obviously reduce the particle size of the modified silica powder on one hand, and promote the ductility and hydrophobicity of the modified silica powder on the other hand, so that the ceramide can be promoted to play a role in moisturizing and resisting aging more quickly and better.
The second aspect of the invention provides application of modified silicon powder prepared by a hypergravity acceleration process in skin care products and color cosmetics.
The beneficial effects are that:
the modified silicon powder provided by the application has the following advantages:
(1) The liposome with high safety and strong skin affinity is prepared by adopting ceramide NP and hydrogenated lecithin through a specific mixing process, and active ingredients are mutually added, so that on one hand, the stratum corneum can be effectively softened, the skin softness and permeability are enhanced, the penetration of the functional ingredients is facilitated, and the regeneration and growth of skin tissue cells are facilitated; on the other hand, the skin barrier effect can be enhanced, the adhesive force of keratinocytes is enhanced, the skin elasticity is enhanced, a brick wall structure is formed, and the skin aging is delayed; meanwhile, the percutaneous water loss is reduced, a net structure is formed with water molecules of the stratum corneum, the water locking and moisturizing performance is strong, and the water-oil balance of the skin is effectively regulated;
(2) The liposome is grafted on the surface of the silicon powder by adopting a supergravity acceleration process, so that the modified silicon powder which has unique smooth skin feel, light and thin texture and is easy to spread is obtained, and the formula stability is strong when the modified silicon powder is applied to cosmetics; meanwhile, the specific flooding gas is adopted to act on the materials, so that the molecular binding force among the raw materials and the formation of a powder microstructure are promoted, the obtained modified silicon powder is small in particle size and narrow in distribution, can effectively fill skin fine lines and blur skin flaws, has extremely strong hydrophobic characteristics, can adsorb grease on the surface layer of the skin, can control makeup for a long time and can realize the effects of moisturizing and nourishing the skin;
(3) The preparation method has the advantages that the raw materials are easy to obtain, the process is simple and convenient, the safety and the mildness are realized when the preparation method acts on the surface of skin, the flying powder is not easy to realize, the problems of difficult spreading of silicon powder, poor ceramide permeability and poor formula compatibility are solved, the practical application of moisturizing active ingredients is widened, and the obtained modified silicon powder can be used in skin care products and color cosmetic products, and has a wide application prospect.
Drawings
FIG. 1. Effect of example 1 after direct application to skin (left: application example 1; right: blank).
Detailed Description
Example 1.
The embodiment provides modified silicon powder prepared by a supergravity acceleration process, and the preparation process of the modified silicon powder comprises the following steps:
s1, preparing liposome;
s2, mixing the liposome, the siloxane compound and the silicon powder in a hypergravity rotating bed to obtain a modified silicon powder finished product.
The preparation raw materials of the liposome comprise a wrapper and a wrapping carrier, wherein the weight ratio of the wrapper to the wrapping carrier is 1:4.
the step S1 specifically comprises the following steps: adding the wrapper and the wrapping carrier into the oiling agent, and heating and uniformly stirring to obtain a phase A; water and polyhydroxy compound are mixed according to the mass ratio of 1:3, mixing to obtain a phase B; mixing the materials of the phase A and the phase B, transferring to a high-pressure micro-jet homogenizer, and homogenizing for 5min under 125MPa to obtain the liposome finished product.
The weight ratio of the phase A to the phase B is 1:1.
The addition amount of the oiling agent is 2 times of the mass of the wrapper; the oil agent is vegetable oil, specifically calendula (Calendula officinalis L.) oil and tea tree (Camellia sinensis L.) O.Ktze.) oil, and the weight ratio of calendula oil to tea tree oil is 1:3.5.
The calendula oil is derived from Herb pharm; the tea tree oil is derived from Shaanxi Huashi biosciences Inc.
The step S2 is specifically that liposome, siloxane compound and silicon powder are mixed according to the weight ratio of 4:1:100, adding water 40 times of the mass of the silicon powder, and uniformly stirring to obtain a mixture; introducing the mixture into a super gravity rotating bed at a flow rate of 20g/min at 75deg.C, and at the same time at a flow rate of 2m 3 Introducing flooding gas into the flow rate of/h, reacting for 20min under the condition of 1500rpm, washing with deionized water for 3 times, filtering, and vacuum drying to obtain the modified silicon powder finished product.
The silicon powder has the Mohs hardness of 6 and the thermal conductivity of 1.1W/K.M, and is obtained from the Innovative materials science and technology Co of Liyun Kong Rui, and the model is SHA-0050.
The flooding gas is carbon dioxide, and the boiling point of the carbon dioxide is-78.5 ℃.
The ceramide is ceramide NP with CAS number 100403-19-8.
The wrapping carrier is hydrogenated lecithin, and the CAS number is 92128-87-5.
The siloxane compound is n-octyl triethoxysilane and polydimethylsiloxane; the weight ratio of n-octyl triethoxysilane to polydimethylsiloxane is 1:2.
the functionality of the polyhydroxy compound is 3, the melting point is 18.2 ℃, the surface tension is 61.9dyne/cm, namely the polyhydroxy compound is glycerol, and the CAS number is 56-81-5.
The second aspect of the invention provides application of modified silicon powder prepared by a hypergravity acceleration process in skin care products and color cosmetics.
Example 2.
The embodiment provides modified silicon powder prepared by a supergravity acceleration process, and the preparation process of the modified silicon powder comprises the following steps:
s1, preparing liposome;
s2, mixing the liposome, the siloxane compound and the silicon powder in a hypergravity rotating bed to obtain a modified silicon powder finished product.
The preparation raw materials of the liposome comprise a wrapper and a wrapping carrier, wherein the weight ratio of the wrapper to the wrapping carrier is 1:4.
the step S1 specifically comprises the following steps: adding the wrapper and the wrapping carrier into the oiling agent, and heating and uniformly stirring to obtain a phase A; water and polyhydroxy compound are mixed according to the mass ratio of 1:2.5, mixing to obtain a phase B; mixing the materials of the phase A and the phase B, transferring to a high-pressure micro-jet homogenizer, and homogenizing for 5min under 115MPa to obtain the liposome finished product.
The weight ratio of the phase A to the phase B is 1:1.
The addition amount of the oiling agent is 2 times of the mass of the wrapper; the oil agent is vegetable oil, specifically calendula (Calendula officinalis L.) oil and tea tree (Camellia sinensis L.) O.Ktze.) oil, and the weight ratio of calendula oil to tea tree oil is 1:3.5.
The calendula oil is derived from Herb pharm; the tea tree oil is derived from Shaanxi Huashi biosciences Inc.
The step S2 is specifically that liposome, siloxane compound and silicon powder are mixed according to the weight ratio of 6:2.5:100, adding water with the mass of 50 times that of the silicon powder, and uniformly stirring to obtain a mixture; introducing the mixture into a super gravity rotating bed at a flow rate of 20g/min at 75deg.C, and at the same time at a flow rate of 2m 3 Introducing flooding gas into the flow rate of/h, reacting for 20min under the condition of 1500rpm, washing with deionized water for 3 times, filtering, and vacuum drying to obtain the modified silicon powder finished product.
The silicon powder has the Mohs hardness of 6 and the thermal conductivity of 1.1W/K.M, and is obtained from the Innovative materials science and technology Co of Liyun Kong Rui, and the model is SHA-0050.
The flooding gas is carbon dioxide, and the boiling point of the carbon dioxide is-78.5 ℃.
The ceramide is ceramide NP with CAS number 100403-19-8.
The wrapping carrier is hydrogenated lecithin, and the CAS number is 92128-87-5.
The siloxane compound is n-octyl triethoxysilane and polydimethylsiloxane; the weight ratio of n-octyl triethoxysilane to polydimethylsiloxane is 1:2.
the functionality of the polyhydroxy compound is 3, the melting point is 18.2 ℃, the surface tension is 61.9dyne/cm, namely the polyhydroxy compound is glycerol, and the CAS number is 56-81-5.
The second aspect of the invention provides application of modified silicon powder prepared by a hypergravity acceleration process in skin care products and color cosmetics.
Example 3.
The embodiment provides modified silicon powder prepared by a supergravity acceleration process, and the preparation process of the modified silicon powder comprises the following steps:
s1, preparing liposome;
s2, mixing the liposome, the siloxane compound and the silicon powder in a hypergravity rotating bed to obtain a modified silicon powder finished product.
The preparation raw materials of the liposome comprise a wrapper and a wrapping carrier, wherein the weight ratio of the wrapper to the wrapping carrier is 1:4.
the step S1 specifically comprises the following steps: adding the wrapper and the wrapping carrier into the oiling agent, and heating and uniformly stirring to obtain a phase A; water and polyhydroxy compound are mixed according to the mass ratio of 1:2.5, mixing to obtain a phase B; mixing the materials of the phase A and the phase B, transferring to a high-pressure micro-jet homogenizer, and homogenizing for 5min under 125MPa to obtain the liposome finished product.
The silicon powder has the Mohs hardness of 6 and the thermal conductivity of 1.1W/K.M, and is obtained from the Innovative materials science and technology Co of Liyun Kong Rui, and the model is SHA-0050.
The weight ratio of the phase A to the phase B is 1:1.
The addition amount of the oiling agent is 2 times of the mass of the wrapper; the oil agent is vegetable oil, specifically calendula (Calendula officinalis L.) oil and tea tree (Camellia sinensis L.) O.Ktze.) oil, and the weight ratio of calendula oil to tea tree oil is 1:5.
The calendula oil is derived from Herb pharm; the tea tree oil is derived from Shaanxi Huashi biosciences Inc.
The step S2 is specifically that liposome, siloxane compound and silicon powder are mixed according to the weight ratio of 4:1:100, adding water 40 times of the mass of the silicon powder, and uniformly stirring to obtain a mixture; introducing the mixture into a super gravity rotating bed at a flow rate of 30g/min at 75deg.C, and at the same time at a flow rate of 2.5m 3 Introducing flooding gas into the flow rate of/h, reacting for 20min under the condition of 1500rpm, washing with deionized water for 3 times, filtering, and vacuum drying to obtain the modified silicon powder finished product.
The flooding gas is carbon dioxide, and the boiling point of the carbon dioxide is-78.5 ℃.
The ceramide is ceramide NP with CAS number 100403-19-8.
The wrapping carrier is hydrogenated lecithin, and the CAS number is 92128-87-5.
The siloxane compound is n-octyl triethoxysilane and polydimethylsiloxane; the weight ratio of n-octyl triethoxysilane to polydimethylsiloxane is 1:3.
the functionality of the polyhydroxy compound is 3, the melting point is 18.2 ℃, the surface tension is 61.9dyne/cm, namely the polyhydroxy compound is glycerol, and the CAS number is 56-81-5.
The second aspect of the invention provides application of modified silicon powder prepared by a hypergravity acceleration process in skin care products and color cosmetics.
Example 4.
The embodiment provides modified silicon powder prepared by a supergravity acceleration process, and the preparation process of the modified silicon powder comprises the following steps:
s1, preparing liposome;
s2, mixing the liposome, the siloxane compound and the silicon powder in a hypergravity rotating bed to obtain a modified silicon powder finished product.
The preparation raw materials of the liposome comprise a wrapper and a wrapping carrier, wherein the weight ratio of the wrapper to the wrapping carrier is 1:0.8.
the step S1 specifically comprises the following steps: adding the wrapper and the wrapping carrier into the oiling agent, and heating and uniformly stirring to obtain a phase A; water and polyhydroxy compound are mixed according to the mass ratio of 1:3, mixing to obtain a phase B; mixing the materials of the phase A and the phase B, transferring to a high-pressure micro-jet homogenizer, homogenizing for 8min under the condition of 95MPa, and obtaining a liposome finished product.
The weight ratio of the phase A to the phase B is 1:1.
The addition amount of the oiling agent is 2 times of the mass of the wrapper; the oil agent is vegetable oil, specifically calendula (Calendula officinalis L.) oil and tea tree (Camellia sinensis L.) O.Ktze.) oil, and the weight ratio of calendula oil to tea tree oil is 1:3.5.
The calendula oil is derived from Herb pharm; the tea tree oil is derived from Shaanxi Huashi biosciences Inc.
The step S2 is specifically that liposome, siloxane compound and silicon powder are mixed according to the weight ratio of 4:1:100, adding water 40 times of the mass of the silicon powder, and uniformly stirring to obtain a mixture; introducing the mixture into a super gravity rotating bed at a flow rate of 20g/min at 75deg.C, and at the same time at a flow rate of 2m 3 Introducing flooding gas into the flow rate of/h, reacting for 20min under the condition of 1500rpm, washing with deionized water for 3 times, filtering, and vacuum drying to obtain the modified silicon powder finished product.
The silicon powder has the Mohs hardness of 6 and the thermal conductivity of 1.1W/K.M, and is obtained from the Innovative materials science and technology Co of Liyun Kong Rui, and the model is SHA-0050.
The flooding gas is carbon dioxide, and the boiling point of the carbon dioxide is-78.5 ℃.
The ceramide is ceramide NP with CAS number 100403-19-8.
The wrapping carrier is hydrogenated lecithin, and the CAS number is 92128-87-5.
The siloxane compound is n-octyl triethoxysilane and polydimethylsiloxane; the weight ratio of n-octyl triethoxysilane to polydimethylsiloxane is 1:2.
the functionality of the polyhydroxy compound is 3, the melting point is 18.2 ℃, the surface tension is 61.9dyne/cm, namely the polyhydroxy compound is glycerol, and the CAS number is 56-81-5.
The second aspect of the invention provides application of modified silicon powder prepared by a hypergravity acceleration process in skin care products and color cosmetics.
Example 5.
The embodiment provides modified silicon powder prepared by a supergravity acceleration process, and the preparation process of the modified silicon powder comprises the following steps:
s1, preparing liposome;
s2, mixing the liposome, the siloxane compound and the silicon powder in a hypergravity rotating bed to obtain a modified silicon powder finished product.
The preparation raw materials of the liposome comprise a wrapper and a wrapping carrier, wherein the weight ratio of the wrapper to the wrapping carrier is 1:4.
the step S1 specifically comprises the following steps: adding the wrapper and the wrapping carrier into the oiling agent, and heating and uniformly stirring to obtain a phase A; water and polyhydroxy compound are mixed according to the mass ratio of 1:3, mixing to obtain a phase B; mixing the materials of the phase A and the phase B, transferring to a high-pressure micro-jet homogenizer, and homogenizing for 5min under 125MPa to obtain the liposome finished product.
The weight ratio of the phase A to the phase B is 1:1.
The addition amount of the oiling agent is 2 times of the mass of the wrapper; the oil agent is vegetable oil, specifically calendula (Calendula officinalis L.) oil and tea tree (Camellia sinensis L.) O.Ktze.) oil, and the weight ratio of calendula oil to tea tree oil is 1:3.5.
The calendula oil is derived from Herb pharm; the tea tree oil is derived from Shaanxi Huashi biosciences Inc.
The step S2 is specifically that liposome, siloxane compound and silicon powder are mixed according to the weight ratio of 4:1:100, adding water 40 times of the mass of the silicon powder, and uniformly stirring to obtain a mixture; introducing the mixture into a super gravity rotating bed at a flow rate of 60g/min at 85deg.C, and simultaneously introducing the mixture into the super gravity rotating bed at a flow rate of 5m 3 Flow rate of/hIntroducing flooding gas, reacting for 10min at 3000rpm, washing with deionized water for 3 times, filtering, and vacuum drying to obtain modified silica powder product.
The silicon powder has the Mohs hardness of 6 and the thermal conductivity of 1.1W/K.M, and is obtained from the Innovative materials science and technology Co of Liyun Kong Rui, and the model is SHA-0050.
The flooding gas is carbon dioxide, and the boiling point of the carbon dioxide is-78.5 ℃.
The ceramide is ceramide NP with CAS number 100403-19-8.
The wrapping carrier is hydrogenated lecithin, and the CAS number is 92128-87-5.
The siloxane compound is n-octyl triethoxysilane and polydimethylsiloxane; the weight ratio of n-octyl triethoxysilane to polydimethylsiloxane is 1:2.
the functionality of the polyhydroxy compound is 3, the melting point is 18.2 ℃, the surface tension is 61.9dyne/cm, namely the polyhydroxy compound is glycerol, and the CAS number is 56-81-5.
The second aspect of the invention provides application of modified silicon powder prepared by a hypergravity acceleration process in skin care products and color cosmetics.
Example 6.
The embodiment provides modified silicon powder prepared by a supergravity acceleration process, and the preparation process of the modified silicon powder comprises the following steps:
s1, preparing liposome;
s2, mixing the liposome, the siloxane compound and the silicon powder in a hypergravity rotating bed to obtain a modified silicon powder finished product.
The preparation raw materials of the liposome comprise a wrapper and a wrapping carrier, wherein the weight ratio of the wrapper to the wrapping carrier is 1:4.
the step S1 specifically comprises the following steps: adding the wrapper and the wrapping carrier into the oiling agent, and heating and uniformly stirring to obtain a phase A; water and polyhydroxy compound are mixed according to the mass ratio of 1:3, mixing to obtain a phase B; mixing the materials of the phase A and the phase B, transferring to a high-pressure micro-jet homogenizer, and homogenizing for 5min under 125MPa to obtain the liposome finished product.
The weight ratio of the phase A to the phase B is 1:1.
The adding amount of the oiling agent is 3 times of the mass of the wrapper; the oil agent is vegetable oil, in particular calendula (Calendula officinalis L.) oil.
The calendula oil is derived from Herb pharm.
The step S2 is specifically that liposome, siloxane compound and silicon powder are mixed according to the weight ratio of 8:1:100, adding water with the mass of 30 times that of the silicon powder, and uniformly stirring to obtain a mixture; introducing the mixture into a super gravity rotating bed at 70deg.C and a flow rate of 20g/min, and simultaneously introducing into a super gravity rotating bed at a flow rate of 2m 3 Introducing flooding gas into the flow rate of/h, reacting for 20min under the condition of 1500rpm, washing with deionized water for 3 times, filtering, and vacuum drying to obtain the modified silicon powder finished product.
The silicon powder has the Mohs hardness of 6 and the thermal conductivity of 1.1W/K.M, and is obtained from the Innovative materials science and technology Co of Liyun Kong Rui, and the model is SHA-0050.
The flooding gas is carbon dioxide, and the boiling point of the carbon dioxide is-78.5 ℃.
The ceramide is ceramide NP with CAS number 100403-19-8.
The wrapping carrier is hydrogenated lecithin, and the CAS number is 92128-87-5.
The siloxane compound is n-octyl triethoxysilane and polydimethylsiloxane; the weight ratio of n-octyl triethoxysilane to polydimethylsiloxane is 2:1.
the functionality of the polyhydroxy compound is 3, the melting point is 18.2 ℃, the surface tension is 61.9dyne/cm, namely the polyhydroxy compound is glycerol, and the CAS number is 56-81-5.
The second aspect of the invention provides application of modified silicon powder prepared by a hypergravity acceleration process in skin care products and color cosmetics.
Performance test method
1. Particle size
The particle sizes of the modified silicon powders prepared in examples 1 to 6 were tested using a BSD-660 full-automatic high-performance physical adsorption apparatus and are recorded in Table 1.
2. Hydrophobicity of
Measuring the contact angle of the modified silicon powder prepared in the examples 1-6 by adopting an SDC-200S contact angle measuring instrument, wherein the test medium is water; recorded in table 1.
3. Spreadability of
The modified silicon powder obtained in example 1 was mixed at a rate of 1g/15cm 2 The coating amount of the modified silicon powder is directly coated on an arm (a left side coating example, a right side non-coating sample is used as a blank control), the spreadability of the modified silicon powder is good in the coating process, no flying powder occurs, the skin feel is natural, and the effect comparison is shown in figure 1.
Performance test data
Table 1.

Claims (5)

1. The modified silicon powder prepared by the hypergravity acceleration process is characterized in that the preparation process of the modified silicon powder comprises the following steps:
s1, preparing liposome;
s2, mixing the liposome, the siloxane compound and the silicon powder in a hypergravity rotating bed to obtain a modified silicon powder finished product;
the preparation raw materials of the liposome comprise a wrapper and a wrapping carrier, wherein the weight ratio of the wrapper to the wrapping carrier is 1: (1-10);
the step S1 specifically comprises the following steps: adding the wrapper and the wrapping carrier into the oiling agent, and heating and uniformly stirring to obtain a phase A; water and polyhydroxy compound are mixed according to the mass ratio of 1: (6-14) mixing to obtain phase B; mixing the materials of the phase A and the phase B, transferring to a high-pressure micro-jet homogenizer, homogenizing for 2-30min under 100-200MPa to obtain liposome finished product;
the wrapper is ceramide; the ceramide comprises one or more of ceramide EOS, ceramide NP, ceramide EOH, ceramide AS, caproyl sphingosine, ceramide AH, ceramide NH, ceramide EOP, cetyl-PG hydroxyethyl palmitamide; the encapsulation carrier comprises one or more of hydrogenated lecithin, phosphatidylcholine, diphosphatidylglycerol, phosphatidylinositol, tricetyl phosphate;
the step S2 is specifically that liposome, siloxane compound and silicon powder are mixed according to the weight ratio of (1-15):
(0.2-6): 100, adding water with the mass of 30-60 times that of the silicon powder, and uniformly stirring to obtain a mixture; introducing the mixture into a super gravity rotating bed at a flow rate of 10-50g/min at 70-80deg.C, and at the same time at 1-3m 3 Introducing flooding gas into the flow of/h, reacting for 15-30min under the condition of 800-6000rpm, filtering, and drying to obtain the modified silicon powder finished product.
2. The modified silica fume produced by the hypergravity acceleration process according to claim 1, wherein the functionality of the polyhydroxy compound is 1-5, the melting point is 5-30 ℃, and the surface tension is 30-72dyne/cm.
3. A modified silicon powder produced by a supergravity acceleration process according to claim 1, wherein the siloxane compound comprises one or more of n-octyl triethoxysilane, trimethoxysilane, triethoxysilane, isobutyl triethoxysilane, dimethyl diethoxysilane, polydimethylsiloxane, cyclomethicone, polymethylphenylsiloxane, polyether polysiloxane copolymer, aminosilicone.
4. A modified silica powder produced by a supergravity acceleration process according to claim 1, wherein the oiling agent comprises animal oil and/or vegetable oil.
5. Use of the modified silicon powder prepared by the hypergravity acceleration process according to any one of claims 1-4 in skin care products and make-up.
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