CN110037945A - A kind of micelle composition and its preparation method and application - Google Patents
A kind of micelle composition and its preparation method and application Download PDFInfo
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- CN110037945A CN110037945A CN201910332913.6A CN201910332913A CN110037945A CN 110037945 A CN110037945 A CN 110037945A CN 201910332913 A CN201910332913 A CN 201910332913A CN 110037945 A CN110037945 A CN 110037945A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/14—Preparations for removing make-up
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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Abstract
The present invention provides a kind of micelle compositions and its preparation method and application, the micelle composition includes following components by mass percentage: the modified grease 0.1%~15% of the segment containing polyethylene glycol, surfactant 0.1%~50%, glycerol 0.1%~10%, surplus are water；Micelle composition provided by the invention is nonirritant, particle diameter distribution is uniform, between partial size substantially 8~60nm, the overwhelming majority is distributed in 10nm or so, performance is stablized, it is reasonably combined above all through surfactant and PEG-75 sher butter glyceride type, so that foam effect is lasting, exquisiteness is enriched, lower collocation amount can be so that micelle composition has both cleaning and the function of makeup removing is two-in-one, property is mild, when applying in cleansing mousse, transparent cleansing mousse can be obtained, cleaning effect is good, not dry and astringent after use, not tight, application value is higher.
Description
Technical field
The invention belongs to cosmetic field, it is related to a kind of micelle composition and its preparation method and application.
Background technique
With the improvement of living standards, makeup has been the indispensable step of modern female daily life.And the cleaning after adornment
It is the most key step of skin care.Therefore, requirement of the consumer to face's cleaning products is also higher and higher, is not only required
Energy rapid cleaning, deep layer are clean, the All-in-Ones effect such as face cleaning, makeup removing, skin care, also require not stimulate mildly, easy to use etc..
Product face cleaning products on the market can be divided into makeup removal products and two kinds of face cleaning product at present.First, makeup removing produces
Product can be divided into makeup remover, make-up remover, makeup removing breast, four kinds of make up remover.Makeup remover, make-up remover, makeup removing breast cleaning capacity it is relatively strong but
Skin sense is more greasy, and experience sense is poor.Makeup remover is easy to use since skin sense is salubrious, and without washing the features such as receives vast
Consumer's likes, but commercially available makeup remover that there are makeup removing abilities is weak, stimulation eyes, with the weakness such as dry are retrodeviated, limit makeup remover
The further expansion in market.Second, face cleaning product can be divided into mildy wash, face cleaning cream, face cleaning gel, cleansing mousse and face cleaning powder
Five kinds.But the product of face cleaning is confined to the epidermis soil cleaning of face, it is poor to dispel effect for the color make-up of face, especially not
It is suitble to unload eye color make-up, is easy stimulation eyes.Therefore, exploitation is a has both face cleaning and makeup removing effect, and foaming abundancy is fine and smooth, mildly
It does not stimulate, also the cleaning products with skin-care effect have critically important realistic meaning.
Micella is one of colloidal dispersion, belongs to association colloid.The partial size of micella is usually in 200nm hereinafter, belong to
Substance is from macroscopic view to microcosmic transitional region.Since micella special construction includes small-size effect, surface and interfacial effect, amount
Sub- dimensional effect and macro quanta tunnel effect, and there are many special natures not available for conventional matter.Therefore, expect phase
Than preparing face cleaning and makeup removing effect being good in conventional articles, foaming abundancy is fine and smooth, foaming abundancy, the mild cleaning products of property.
Most micella product currently on the market is all that single effect micella water does not have although mild low-stimulation
There is foam.And the almost only simple facial effect of cleaning, the effect that do not remove ornaments and formal dress of mousse product on the market, if mousse produces
The effect removed ornaments and formal dress when product use is obvious, then needs to easily cause stimulation using comparision contents high surfactant, damage skin.
CN106726770A discloses a kind of makeup removing micelle composition and preparation method thereof and the application in makeup remover, by
Following mass percent group is grouped as: the modified grease 0.1~20% of the segment containing polyethylene glycol, nonionic surfactant 0.1
~20%, dipropylene glycol 0.1~10%, surplus is water.The steps included are as follows for the preparation method of this makeup removing micelle composition:
Under normal temperature condition, poly ethyldiol modified grease is mixed in proportion in an aqueous medium with nonionic surfactant, dipropylene glycol,
Form micelle composition；This makeup removing micelle composition forms the micellar solution with certain particle size range, reduces modified grease
Usage amount, effectively makeup removing while reduce modified grease due to permeating the stimulation that generates to skin；The micelle composition is available
In the mild non-stimulated makeup remover of preparation, can be used for the makeup removing of a lip, makeup removing effect is good, and it is easy to use, without washing, use
It is not dry and astringent afterwards, it is not tight.
CN102791255A discloses a kind of micelle composition comprising hydrophobic compound and amphipathic nature block polymer,
Wherein the amphipathic nature block polymer is made of hydrophobic block A and hydrophilic block B, and the hydrophobic block A includes extremely
A kind of few hydrophobic polymer unit X, the hydrophilic block B include at least one hydrophilic polymer unit Y, and wherein X is embedding
Section and Y block are alternately.The micelle composition can be used in following application: medical application (such as cardiovascular treatment application), animal doctor
Using, food processing application, fire retardant application, coating, binder and cosmetics, fabric/textile, industry and art application.
CN109260030A discloses a kind of micelle composition and its preparation method and application, including according to parts by weight
Following component: polyglycereol class and/or 20~60 parts of polyethylene glycols surfactant, 20~60 parts of regulator and amphoteric surface are living
0~60 part of agent of property, wherein regulator includes at least one in carbohydrate regulator, glycoside regulator and polyalcohols regulator
Kind.Each component is mild in the micelle composition, and to no skin irritation, moisture retention is good.Utilize the mutual shadow between each component
It rings, by the reasonable control to each component additional amount, science collocation gives full play to the function of each composition.It is applied to cleaning shield
It in skin product, can alleviate in existing cleaning skin-protection product that dirt-removing power is poor, there is skin irritation and the low problem of cost performance.
Therefore, how to develop one kind and have both makeup removing two kinds of effects of cleaning, also there is mild low-stimulation, foaming abundancy exquisiteness to imitate
The micelle composition of fruit has important value for facial cleansing.
Summary of the invention
In view of the deficiencies of the prior art, the purpose of the present invention is to provide a kind of micelle composition and preparation method thereof and answer
With, solved the problems, such as existing micelle composition there are no foam, effect is single, irritation is higher.
In order to achieve that object of the invention, the invention adopts the following technical scheme:
In a first aspect, the present invention provides a kind of micelle composition, the micelle composition includes by mass percentage
Following components: the modified grease 0.1%~15% of the segment containing polyethylene glycol, surfactant 0.1%~50%, glycerol 0.1%
~10%, surplus is water.
Micelle composition provided by the invention passes through modified grease, surfactant and the glycerol of the segment containing polyethylene glycol
Reasonable collocation can generate fine and smooth foamy appearance so that micellar particle size is evenly distributed, lower collocation amount can so that
Micelle composition has both the function of cleaning and makeup removing, reduces the stimulation of surfactant bring, and property is mild.
Preferably, the micelle composition includes following components by mass percentage: the modification of the segment containing polyethylene glycol
Grease 3%~8%, surfactant 32%~40%, glycerol 6%~9%, surplus are water.
The mass percent of the modified grease of the segment of the present invention containing polyethylene glycol is 0.1%~15%, such as can be with
It is 0.1%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14% or 15% etc..
Preferably, the modified grease of the segment containing polyethylene glycol includes PEG-75 sher butter glyceride type.
Its lipophilicity of PEG-75 sher butter glyceride type is much larger than hydrophily, has the ability of certain dissolution color make-up,
The persistence that also can increase foam simultaneously, makes foam more careful careful, and permeability is weaker, can reduce the stimulation to skin.
And if its dosage excessively increases product consistency, product appearance is influenced, the few then durable lather ability of dosage is poor, therefore its concentration
Range needs specific selection.
The modified grease of the segment of the present invention containing polyethylene glycol is not limited only to the above-mentioned type, be also possible to PEG-6 octanoic acid/
Glycerol decanoate class, PEG-7 glyceryl cocoate, olive oil PEG-7 lipid etc..But the modified grease of these types blisters
Effect is poor.
The mass percent of surfactant of the present invention is 0.1%~50%, for example, can be 0.1%, 1%,
2%, 3%, 4%, 5%, 6%, 10%, 12%, 15%, 20%, 23%, 24%, 30%, 32%, 36%, 40%, 42%,
45% or 50% etc..
Preferably, the surfactant includes PEG-8 iso stearic acid of glycerine ester, lauryl glucose carboxylic acid sodium, cocounut oil
Sulfonylmethyl sodium taurocholate, guar gum trimethyl ammonium chloride, lauryl sulfosuccinic acid monoester disodium, coconut oil list
Acid Ethanolamide Sulfosuccinates disodium, Monododecylphosphate potassium, Cocoamidopropyl betaine, dodecanamide propyl
In hydroxy sulfo lycine, lauryl both sexes sodium acetate any one or at least two combination.
In the present invention, there are many optional surfactants, but the surfactant of different selections or its collocation, for
The performance of micelle composition influences difference.Such as it can also be Plantacare 818, Natrulon H-10 laurate, polyglycereol-
10 oleates etc..
Preferably, the surfactant is PEG-8 iso stearic acid of glycerine ester, lauryl glucose carboxylic acid sodium and cocounut oil acyl
The combination of ylmethyl sodium taurocholate.
In the present invention, PEG-8 iso stearic acid of glycerine ester, lauryl glucose carboxylic acid sodium, cocounut oil acyl methyl taurine sodium
These three substances have preferable hydrophilic and oleophilic effect, and property is mild, smaller to skin irritation, the glue easy to form in water base
Beam, and compounds the micellar solution to form certain particle size range containing poly ethyldiol modified grease, and it is color that modified grease dissolution can be enhanced
The ability of adornment, reduces the usage amount of modified grease, and reduces modified grease due to permeating the stimulation generated to skin.
PEG-8 iso stearic acid of glycerine ester, lauryl glucose carboxylic acid sodium, cocounut oil acyl methyl taurine sodium three, which arrange in pairs or groups, to be used
Effect be it is optimal, wherein lauryl glucose carboxylic acid sodium, cocounut oil acyl methyl taurine sodium both salts substances increase
Enable to the foam generated more lasting after the density of micelle composition, with the collocation of PEG-8 iso stearic acid of glycerine ester.These three
Lacking any one or both of which in surfactant can make the performance of micelle composition decline.
The mass percent of glycerol of the present invention is 0.1%~10%, for example, can be 0.1%, 1%, 2%, 3%,
4%, 5%, 6%, 7%, 8%, 9% or 10% etc..
Glycerol and moisture, oil have relatively good ability of dissolving each other, and to skin irritation very little, imitate with certain moisturizing
Fruit.The addition of glycerol facilitates the formation of system micella, improves the stability of micelle composition, also to the skin effect of composition
There is gain effect.Compared to dipropylene glycol, the more conducively foam of micelle composition is stablized.
As optimal technical scheme, the micelle composition includes following components by mass percentage: PEG-75 butter
Resin glyceride type 5%, PEG-8 iso stearic acid of glycerine ester 8%, lauryl glucose carboxylic acid sodium 18%, cocounut oil acyl methyl ox sulphur
Sour sodium 10%, glycerol 8%, surplus are water.
The performance for the micelle composition that above-mentioned optimal technical scheme provides is best.
Preferably, the micellar particle size of the micelle composition be 8~60nm, such as can be 8nm, 10nm, 12nm,
15nm, 20nm, 25nm, 30nm, 35nm, 40nm, 45nm, 50nm, 55nm or 60nm etc..
Second aspect, the present invention provides a kind of preparation method of micelle composition as described in relation to the first aspect, the systems
Preparation Method includes: to heat up after mixing the modified grease, surfactant, glycerol and water of the segment containing polyethylene glycol, then cool down
To the micelle composition.
In the present invention, by the process to heat up in cooling, the PEG-75 sher butter for being originally used for solid can be made sweet
Grease class is sufficiently mixed with surfactant, glycerol and water, fully dispersed, and the micella foam effect of formation is more preferable.And if only
It is only room temperature preparation, is unable to get uniformly mixed, the good micelle composition of foam effect.
Micelle composition preparation method energy conservation provided by the invention is simple, and process stabilizing can wide popularization and application.
Preferably, the heating is to be warming up to 60~80 DEG C, such as can be 60 DEG C, 62 DEG C, 63 DEG C, 65 DEG C, 70 DEG C, 72
DEG C, 75 DEG C, 78 DEG C, 79 DEG C or 80 DEG C etc., preferably 65 DEG C.
Preferably, the heating carries out under stirring.
Preferably, under soaking condition, the speed of the stirring is 500~1000r/min, for example, can be 500r/min,
550r/min、600r/min、650r/min、700r/min、750r/min、800r/min、850r/min、900r/min、950r/
Min or 1000r/min etc..
Preferably, under soaking condition, time of the stirring is 15~20min, for example, can be 15min, 16min,
17min, 18min, 19min or 20min etc..
Preferably, the cooling is to be cooled to 30~40 DEG C, such as can be 30 DEG C, 31 DEG C, 32 DEG C, 33 DEG C, 34 DEG C, 35
DEG C, 36 DEG C, 37 DEG C, 38 DEG C, 39 DEG C or 40 DEG C etc., preferably 38 DEG C.
Preferably, the cooling carries out under stirring.
Preferably, under cooling state, the speed of the stirring is 500~1000r/min, such as can be 500r/
min、550r/min、600r/min、650r/min、700r/min、750r/min、800r/min、850r/min、900r/min、
950r/min or 1000r/min etc..
Preferably, under cooling state, time of the stirring is 20~30min, for example, can be 20min, 21min,
22min, 23min, 24min, 25min, 26min, 27min, 28min, 29min or 30min etc..
The third aspect, the present invention provides a kind of cleansing mousse, the cleansing mousse includes glue as described in relation to the first aspect
Beam composition.
Preferably, mass percent of the micelle composition in cleansing mousse is 5%~40%；Preferably 10%~
30%.
In the present invention, when micelle composition is applied in cleansing mousse, content cannot it is excessively high can not be too low.If
Content is too low, and good blistering, cleaning effect is not achieved；If too high levels, it is likely to result in excessive irritation, is caused
It is uncomfortable.
Preferably, the cleansing mousse further includes any one in skin conditioning agent, chelating agent, preservative or odorant
Or at least two combination.
Skin conditioning agent of the present invention can be the substance with whitening, moisturizing, anti-aging, anti-acne and other effects；This hair
The bright chelating agent can be the chelating agent commonly used in the art such as EDTA, EDDHA, PCA；Preservative of the present invention can be benzene
Methanol, benzoic acid, salicylic acid, boric acid, sorbic acid etc. substance；Odorant of the present invention can be the dulcet natural production of tool
Object, Ester etc..
Compared with the existing technology, the invention has the following advantages:
Micelle composition provided by the invention is nonirritant, and particle diameter distribution is uniform, big absolutely between partial size substantially 8~60nm
Part is distributed in 10nm or so, and performance is stablized, it is most important that passes through surfactant and PEG-75 sher butter glyceride type
It is reasonably combined so that foam effect is lasting, enrich exquisiteness, lower collocation amount can so that micelle composition have both cleaning and
The function of makeup removing is two-in-one, and property is mild, and when applying in cleansing mousse, transparent cleansing mousse can be obtained, and cleaning effect is good,
Not dry and astringent after use, not tight, application value is higher.
Preparation method energy conservation provided by the invention is simple, and process stabilizing can wide popularization and application.
Detailed description of the invention
Fig. 1 is each sample hemolysis rate test result figure under various concentration in experimental example 1 of the present invention.
Fig. 2 is the grain size distribution of micelle composition in experimental example 3 of the present invention.
Fig. 3 is the grain size distribution of sample b in experimental example 3 of the present invention.
Fig. 4 is the grain size distribution of comparative example in experimental example 3 of the present invention.
Specific embodiment
The technical scheme of the invention is further explained by means of specific implementation.Those skilled in the art should be bright
, the described embodiments are merely helpful in understanding the present invention, should not be regarded as a specific limitation of the invention.
Reagent used in the present invention can be directly commercially available, and the model of some of reagents is as follows:
PEG-75 sher butter glyceride type, producer: AAK；Trade name: Lipex 102E75.
PEG-8 iso stearic acid of glycerine ester, producer: Japan three is lucky (day cream)；Trade name: M-FINEOIL ISG-8M (GWIS-
108)。
Lauryl glucose carboxylic acid sodium, producer: BASF；Trade name: Planoapon LGC SORB NA.
Cocounut oil acyl methyl taurine sodium, producer: Japanese day oil；Trade name: DIAPON K-SG.
Embodiment 1
The present embodiment provides a kind of micelle composition, the micelle composition includes following components by mass percentage:
PEG-75 sher butter glyceride type 5%, PEG-8 iso stearic acid of glycerine ester 8%, lauryl glucose carboxylic acid sodium
18%, cocounut oil acyl methyl taurine sodium 10%, glycerol 8%, surplus is water.
Embodiment 2
The present embodiment provides a kind of micelle composition, the micelle composition includes following components by mass percentage:
PEG-75 sher butter glyceride type 3%, PEG-8 iso stearic acid of glycerine ester 5%, lauryl glucose carboxylic acid sodium
14%, cocounut oil acyl methyl taurine sodium 13%, glycerol 6%, surplus is water.
Embodiment 3
The present embodiment provides a kind of micelle composition, the micelle composition includes following components by mass percentage:
PEG-75 sher butter glyceride type 8%, PEG-8 iso stearic acid of glycerine ester 10%, lauryl glucose carboxylic acid sodium
20%, cocounut oil acyl methyl taurine sodium 10%, glycerol 9%, surplus is water.
Embodiment 4
The present embodiment provides a kind of micelle composition, the micelle composition includes following components by mass percentage:
PEG-75 sher butter glyceride type 5%, lauryl glucose carboxylic acid sodium 22%, cocounut oil acyl methyl taurine sodium
14%, glycerol 8%, surplus is water.
Embodiment 5
The present embodiment provides a kind of micelle composition, the micelle composition includes following components by mass percentage:
PEG-75 sher butter glyceride type 5%, PEG-8 iso stearic acid of glycerine ester 17%, cocounut oil acyl methyl taurine sodium
19%, glycerol 8%, surplus is water.
Embodiment 6
The present embodiment provides a kind of micelle composition, the micelle composition includes following components by mass percentage:
PEG-75 sher butter glyceride type 5%, PEG-8 iso stearic acid of glycerine ester 13%, lauryl glucose carboxylic acid sodium
23%, glycerol 8%, surplus is water.
Embodiment 7
The present embodiment provides a kind of micelle composition, the micelle composition includes following components by mass percentage:
PEG-75 sher butter glyceride type 5%, PEG-8 iso stearic acid of glycerine ester 36%, glycerol 8%, surplus are water.
Embodiment 8
The present embodiment provides a kind of micelle composition, the micelle composition includes following components by mass percentage:
PEG-6 caprylic/capric glyceride type 5%, PEG-8 iso stearic acid of glycerine ester 8%, lauryl glucose carboxylic acid sodium
18%, cocounut oil acyl methyl taurine sodium 10%, glycerol 8%, surplus is water.
Embodiment 9
The present embodiment provides a kind of micelle composition, the micelle composition includes following components by mass percentage:
PEG-75 sher butter glyceride type 5%, Plantacare 818 8%, Natrulon H-10 laurate 18%, polyglycereol-
10 oleates 10%, glycerol 8%, surplus are water.
Comparative example 1
This comparative example the difference from embodiment 1 is that, in this comparative example do not contain PEG-75 sher butter glyceride type.
Comparative example 2
This comparative example the difference from embodiment 1 is that, in this comparative example do not contain surfactant, that is, do not include PEG-8
Iso stearic acid of glycerine ester, lauryl glucose carboxylic acid sodium and cocounut oil acyl methyl taurine sodium.
Comparative example 3
This comparative example the difference from embodiment 1 is that, glycerol is replaced with into dipropylene glycol in this comparative example.
Comparative example 4
This comparative example the difference from embodiment 1 is that, the quality hundred of PEG-75 sher butter glyceride type in this comparative example
Divide than being 20%, in addition to water, remaining component and mass percent are constant.
Comparative example 5
This comparative example the difference from embodiment 1 is that, PEG-8 iso stearic acid of glycerine ester 14%, lauryl grape saccharide carboxylic acids
Sodium 24%, cocounut oil acyl methyl taurine sodium 16%, in addition to water, remaining component and mass percent are constant.
Comparative example 6
A kind of makeup removing micelle composition, segment containing polyethylene glycol are prepared according to the formula of embodiment 2 in CN106726770A
Modified grease 10%, nonionic surfactant 10%, dipropylene glycol 5%, surplus is water.
Application examples
The micelle composition that embodiment 1 provides is prepared into 4 kinds of cleansing mousses, specific formula and percentage composition (%) composition
It is as shown in table 1 below:
Table 1
Wherein suitable meaning described in table 1 are as follows: those skilled in the art can suitably adjust preservative according to the actual situation
With the content of odorant；Surplus is supplemented with water.
Cleansing mousse the preparation method comprises the following steps: (1) in proportion weighs up water, EDETATE SODIUM, Anjidew NL50 in proportion, in order according to
It is secondary to be added in vacuum emulsification pot, 80 DEG C are warming up to, stirring makes it be thoroughly mixed dissolution, keeps the temperature 10min, opens cooling.
(2) micelle composition is warming up to 65 DEG C, dissolved fully transparent stand-by.
(3) when system temperature is down to 45 DEG C, cleaning micelle composition is added, stirs evenly, sequentially add preservative, assign
Pastil stirs evenly.
(4) qualified stirring discharging obtains above-mentioned 4 kinds of cleansing mousses after detecting.
In addition, using the cleansing mousse of certain commercially available famous brand name as comparative example, ingredient include water, glycerol, maltitol,
Propylene glycol, polyethylene glycol -150, sodium cocoyl glutamate, lauroyl NaAsp, lauryl hydroxyl sulfo betaine, poly- mountain
Pears alcohol ester -60, EDETATE SODIUM, dipotassium glycyrrhizinate, potassium hydroxide, methyl hydroxybenzoate, Phenoxyethanol.
By in above application examples 4 kinds of cleansing mousses a, b, c, d and comparative example carry out test erythrocyte hemolysis experiment survey
Examination, cleaning effect evaluation and droplet measurement, specific as follows:
Experimental example 1
Erythrocyte hemolysis experiment
Lipid and albumen principle similar with the cell membrane of red blood cell based on human skin surface, thus to given the test agent
The irritation of skin surface is assessed.According to European alternative authentication center (ECVAM) RBC experimental test procedures and
Grade scale determines test result, with specific reference to (ECVAM.ECVAM DB-ALM:INVITIONX Protoco, Red
blood cells test system.INVITOX No.37 Ispra.Italy:ECVAM,1994.).Obtained result such as table
Shown in 2 and shown in Fig. 1:
Table 2
It is learnt using micellar technology by the experimental data L/D of table 2 and Fig. 1 using surfactant and water-soluble modified oil
Rouge, which compounds, to be formed the sample stimulus of micellar solution and substantially reduces, and non-stimulated rank is approached or arrived at, and it is living that non-surface is not used
Property agent it is more obvious compared with the sample stimulus that water-soluble grease is wrapped up.Compare the hemolysis rate of each sample, addition cleaning
Sample a, b, c of micelle composition concentration below 0.5% are in not haemolysis, and sample d and comparative example be then 0.01% with
Down in not haemolysis, therefore it may determine that the irritation of sample a, b, c of addition cleaning micelle composition are far below comparative example and sample
Product d.
Experimental example 2
Using 20 female volunteers as research object, the age at 25-50 years old, select the BB of equivalent white (w/o type), eye shadow,
Informer's lipstick carries out full face makeup, then respectively using the sample b of equivalent and commercially available preferable cleansing mousse (the table living body of evaluation
System), mousse is used cooperatively together with makeup removing cotton.Left face uses the transparent mousse of sample b face cleaning, and right face is preferable using commercially available evaluation
Cleansing mousse, evaluate face cleaning after skin sense and makeup removing effect.It the results are shown in Table shown in 3.
Table 3
By this experimental result, it is known that cleaning of the sample b than comparative example (certain commercially available preferable famous brand name cleansing mousse)
Effect will be got well, be using rear skin sense it is salubrious, and comparative example (commercially available preferable certain famous brand name cleansing mousse) with rear skin sense
Be it is greasy, have very big stimulation to eye, after having cleaned, have part color make-up stop.And volunteer is unloading eye using sample b
When color make-up, eye is also almost without experiencing excitement.Thus the transparent mousse of the present invention have preferable face cleaning, makeup removing effect and
Very salubrious use feeling, and it is mild non-stimulated, it can be used for face cleaning and makeup removing use.
Experimental example 3
Partial size test
HORIBA nano-particle size analysis instrument SZ-100 is quoted, using Measurement of particle size distribution by laser diffraction to implementation
The cleansing mousse of micelle composition, sample b and comparative example preparation that example 1 provides carries out diameter characterization.As a result such as Fig. 2, Fig. 3,
Shown in Fig. 4.
From figure we it can be concluded that, its micellar particle size of micelle composition prepared by the present invention is between 8~60nm, big portion
It is distributed in 10nm or so, even if being added in formula, significant change does not also occur for micellar particle size size, it was demonstrated that the cleaning
Micelle composition can be stable in the presence of in system, at the same demonstrate addition micelle composition sample b particle diameter distribution with than
Particle diameter distribution compared with example (certain commercially available preferable famous brand name cleansing mousse) is distinguishing, the particle diameter distribution ratio of sample b system
It is more single, and the partial size of comparative example is more complicated.
By the test of experimental example 1-3 it is found that the cleansing mousse that is prepared into of micelle composition provided by the invention compared to
Commercial product irritation is lower, and more evenly, skin sense effect is more preferable for particle diameter distribution.And it demonstrates when not contained in micelle composition
When PEG-75 sher butter glyceride type, there is decline irritation and is promoted in the performance of micelle composition.
Experimental example 4
The micelle composition provided in embodiment 1-9 and comparative example 1-6 is subjected to foam effect test and irritation is tested.
Wherein irritation test is used to measure micella group with the method in experimental example 1 using erythrocyte hemolysis experiment test
Close the irritation of object.
The method of foam effect test are as follows: compared using the foam volume of same press pump packaging material, same dynamics and compression number.
Specific test result is as shown in table 4:
Table 4
As shown in Table 4, one of or two kinds surfactants, foaming effect have been lacked in embodiment 5-7
It is deteriorated, when being especially the absence of two kinds of sodium salts, is generated without foam；Surfactant is not contained in comparative example 2, does not have blistering yet
Effect.
PEG-75 sher butter glyceride type and surfactant are replaced with into other compositions preparation plastic in embodiment 8-9
When beam composition, foaming effect is deteriorated.Influence of the selection of surfactant for foaming effect is bigger.
When not containing PEG-75 sher butter glyceride type in comparative example 1, doubtful it can also blister；But when without containing surface
When activating agent or surfactant vary widely, it can not blister.
It can also be seen that glycerol can promote micelle composition to blister in comparative example 3-5；And PEG-75 sher butter glyceride
Class and the content of surfactant change, and can foaming effect be decreased.
Although the micelle composition provided in comparative example 6 has low irritant, its effect for not having blistering.
The Applicant declares that the present invention is explained by the above embodiments micelle composition of the invention and preparation method thereof and
Using, but the invention is not limited to above-mentioned processing steps, that is, do not mean that the present invention must rely on above-mentioned processing step ability
Implement.It should be clear to those skilled in the art, any improvement in the present invention, to raw material selected by the present invention etc.
Effect replacement and addition, the selection of concrete mode of auxiliary element etc., all of which fall within the scope of protection and disclosure of the present invention.
Claims (10)
1. a kind of micelle composition, which is characterized in that the micelle composition includes following components by mass percentage: containing poly-
The modified grease 0.1%~15% of ethylene glycol segment, surfactant 0.1%~50%, glycerol 0.1%~10%, surplus are
Water.
2. micelle composition according to claim 1, which is characterized in that the micelle composition wraps by mass percentage
Include following components: the modified grease 3%~8% of the segment containing polyethylene glycol, surfactant 32%~40%, glycerol 6%~
9%, surplus is water.
3. micelle composition according to claim 1 or 2, which is characterized in that the modified oil of the segment containing polyethylene glycol
Rouge includes PEG-75 sher butter glyceride type.
4. micelle composition according to any one of claim 1-3, which is characterized in that the surfactant includes
PEG-8 iso stearic acid of glycerine ester, lauryl glucose carboxylic acid sodium, sodium cocoyl methyl sodium taurocholate, guar gum hydroxypropyl three
Ammonio methacrylate, lauryl sulfosuccinic acid monoester disodium, Coconut Fatty Acid Monoethanolamide sulfosuccinic acid monoesters disodium, single 12
Alkyl phosphate potassium, Cocoamidopropyl betaine, dodecanamide propyl hydroxy sulfo lycine, in lauryl both sexes sodium acetate
Any one or at least two combination；
Preferably, the surfactant is PEG-8 iso stearic acid of glycerine ester, lauryl glucose carboxylic acid sodium and cocoyl first
The combination of base sodium taurocholate.
5. micelle composition described in any one of -4 according to claim 1, which is characterized in that the micelle composition presses quality
Percentages include following components: PEG-75 sher butter glyceride type 5%, PEG-8 iso stearic acid of glycerine ester 8%, lauryl
Glucose carboxylic acid sodium 18%, cocounut oil acyl methyl taurine sodium 10%, glycerol 8%, surplus is water；
Preferably, the micellar particle size of the micelle composition is 8~60nm.
6. the preparation method of micelle composition according to any one of claims 1-5, which is characterized in that the preparation side
Method includes: to heat up after mixing the modified grease, surfactant, glycerol and water of the segment containing polyethylene glycol, then cool down to obtain institute
State micelle composition.
7. preparation method according to claim 6, which is characterized in that the heating is to be warming up to 60~80 DEG C；Preferably
65℃；
Preferably, the heating carries out under stirring；
Preferably, the speed of the stirring is 500~1000r/min；
Preferably, the time of the stirring is 15~20min.
8. preparation method according to claim 6 or 7, which is characterized in that the cooling is to be cooled to 30~40 DEG C；It is preferred that
It is 38 DEG C；
Preferably, the cooling carries out under stirring；
Preferably, the speed of the stirring is 500~1000r/min；
Preferably, the time of the stirring is 20~30min.
9. a kind of cleansing mousse, which is characterized in that the cleansing mousse includes micella according to any one of claims 1 to 5
Composition.
10. cleansing mousse according to claim 9, which is characterized in that matter of the micelle composition in cleansing mousse
Measuring percentage is 5%~40%；Preferably 10%~30%；
Preferably, the cleansing mousse further include in skin conditioning agent, chelating agent, preservative or odorant any one or extremely
Few two kinds of combination.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110327235A (en) * | 2019-08-19 | 2019-10-15 | 广州环亚化妆品科技有限公司 | It is a kind of to play close soft cleansing mousse and preparation method thereof |
| CN112545935A (en) * | 2020-12-10 | 2021-03-26 | 广东诗妃化妆品有限公司 | Nano-encapsulated surfactant composition and preparation method thereof |
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| WO2017194965A1 (en) * | 2016-05-13 | 2017-11-16 | Phytoceutical Limited | Micelles of d-alpha-tocopheryl polyethylene glycol 1000 succinate |
| CN109260030A (en) * | 2018-12-03 | 2019-01-25 | 滨海昌正企业管理有限公司 | Micelle composition and its preparation method and application |
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| CN104000766A (en) * | 2014-06-17 | 2014-08-27 | 广州市雅蝶化妆品制造有限公司 | Effective gentle makeup-removing micelle liquid |
| WO2017194965A1 (en) * | 2016-05-13 | 2017-11-16 | Phytoceutical Limited | Micelles of d-alpha-tocopheryl polyethylene glycol 1000 succinate |
| CN106726770A (en) * | 2016-12-28 | 2017-05-31 | 广州环亚化妆品科技有限公司 | A kind of makeup removing micelle composition and preparation method thereof and the application in makeup remover |
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| CN112545935A (en) * | 2020-12-10 | 2021-03-26 | 广东诗妃化妆品有限公司 | Nano-encapsulated surfactant composition and preparation method thereof |
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Address after: 510663 No.15, Kelin Road, Guangzhou Science City, Guangzhou high tech Industrial Development Zone, Guangdong Province Patentee after: Guangzhou Huanya cosmetics technology Co.,Ltd. Address before: 510663 No.15, Kelin Road, Guangzhou Science City, Guangzhou high tech Industrial Development Zone, Guangdong Province Patentee before: GUANGZHOU HUANYA COSMETICS TECHNOLOGY Co.,Ltd. |