CN115348862A - 用于复发型多发性硬化症(rms)的治疗性酪氨酸激酶抑制剂 - Google Patents

用于复发型多发性硬化症(rms)的治疗性酪氨酸激酶抑制剂 Download PDF

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Publication number
CN115348862A
CN115348862A CN202180009557.XA CN202180009557A CN115348862A CN 115348862 A CN115348862 A CN 115348862A CN 202180009557 A CN202180009557 A CN 202180009557A CN 115348862 A CN115348862 A CN 115348862A
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CN
China
Prior art keywords
btk inhibitor
dose
multiple sclerosis
lesions
weeks
Prior art date
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Pending
Application number
CN202180009557.XA
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English (en)
Chinese (zh)
Inventor
M·赵
T·J·特纳
E·沃尔斯特罗姆
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Principia Biopharma Inc
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of CN115348862A publication Critical patent/CN115348862A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202180009557.XA 2020-01-20 2021-01-19 用于复发型多发性硬化症(rms)的治疗性酪氨酸激酶抑制剂 Pending CN115348862A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202062963238P 2020-01-20 2020-01-20
US62/963,238 2020-01-20
US202062970502P 2020-02-05 2020-02-05
US62/970,502 2020-02-05
US202063013895P 2020-04-22 2020-04-22
US63/013,895 2020-04-22
PCT/US2021/013883 WO2021150476A1 (en) 2020-01-20 2021-01-19 Therapeutic tyrosine kinase inhibitors for relapsing multiple sclerosis (rms)

Publications (1)

Publication Number Publication Date
CN115348862A true CN115348862A (zh) 2022-11-15

Family

ID=74626161

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180009557.XA Pending CN115348862A (zh) 2020-01-20 2021-01-19 用于复发型多发性硬化症(rms)的治疗性酪氨酸激酶抑制剂

Country Status (12)

Country Link
US (2) US11969418B2 (https=)
EP (1) EP4093397A1 (https=)
JP (2) JP2023510604A (https=)
KR (1) KR20220130179A (https=)
CN (1) CN115348862A (https=)
AU (1) AU2021209608A1 (https=)
BR (1) BR112022014058A2 (https=)
CA (1) CA3168146A1 (https=)
IL (1) IL294560A (https=)
MX (1) MX2022008875A (https=)
TW (1) TWI883107B (https=)
WO (1) WO2021150476A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117295735A (zh) * 2021-04-23 2023-12-26 杭州领业医药科技有限公司 Tolebrutinib晶型、无定型及其制备方法和用途

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Publication number Priority date Publication date Assignee Title
BR112022014058A2 (pt) 2020-01-20 2022-09-13 Genzyme Corp Inibidores terapêuticos de tirosina cinase para esclerose múltipla recidivante (rms)
AU2021398051A1 (en) * 2020-12-10 2023-07-27 Principia Biopharma Inc. Crystal form of tolebrutinib, preparation method therefor and use thereof
CN117412749A (zh) * 2021-05-21 2024-01-16 杭州领业医药科技有限公司 Tolebrutinib盐及其晶型、其制备方法、其药物组合物和用途
WO2022257845A1 (zh) * 2021-06-11 2022-12-15 苏州科睿思制药有限公司 Tolebrutinib的晶型及其制备方法和用途
WO2023280132A1 (zh) * 2021-07-06 2023-01-12 苏州晶云药物科技股份有限公司 氧代二氢咪唑并吡啶类化合物的晶型及其制备方法
CA3260159A1 (en) * 2022-06-30 2024-01-04 Principia Biopharma Inc. Therapeutic Tyrosine Kinase Inhibitors for the Treatment of Multiple Sclerosis and Myasthenia Gravis
EP4601647A1 (en) * 2022-10-11 2025-08-20 Principia Biopharma Inc. Therapeutic tyrosine kinase inhibitors for multiple sclerosis
AU2023408758A1 (en) * 2022-12-20 2025-07-31 Principia Biopharma Inc. Drug formulations of (r)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4- phenoxyphenyl)-1h-imidazo[4,5-c]pyridin-2(3h)-one
JP2026505764A (ja) 2023-02-01 2026-02-18 プリンシピア バイオファーマ インコーポレイテッド 多発性硬化症を診断及び治療する方法
WO2025264860A2 (en) 2024-06-18 2025-12-26 Yale University Methods of treating post-covid airway disease

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117295735A (zh) * 2021-04-23 2023-12-26 杭州领业医药科技有限公司 Tolebrutinib晶型、无定型及其制备方法和用途

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Publication number Publication date
WO2021150476A1 (en) 2021-07-29
TW202140002A (zh) 2021-11-01
EP4093397A1 (en) 2022-11-30
TWI883107B (zh) 2025-05-11
MX2022008875A (es) 2022-08-11
CA3168146A1 (en) 2021-07-29
US20240366585A1 (en) 2024-11-07
US20210244720A1 (en) 2021-08-12
US11969418B2 (en) 2024-04-30
JP2023510604A (ja) 2023-03-14
KR20220130179A (ko) 2022-09-26
BR112022014058A2 (pt) 2022-09-13
IL294560A (en) 2022-09-01
AU2021209608A1 (en) 2022-09-15
JP2026001038A (ja) 2026-01-06

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Effective date of registration: 20240726

Address after: new jersey

Applicant after: PRINCIPIA BIOPHARMA Inc.

Country or region after: U.S.A.

Address before: Massachusetts, USA

Applicant before: Genzyme Corp.

Country or region before: U.S.A.