KR20220130179A - 재발성 다발성 경화증(rms)에 대한 치료용 티로신 키나제 저해제 - Google Patents

재발성 다발성 경화증(rms)에 대한 치료용 티로신 키나제 저해제 Download PDF

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Publication number
KR20220130179A
KR20220130179A KR1020227028409A KR20227028409A KR20220130179A KR 20220130179 A KR20220130179 A KR 20220130179A KR 1020227028409 A KR1020227028409 A KR 1020227028409A KR 20227028409 A KR20227028409 A KR 20227028409A KR 20220130179 A KR20220130179 A KR 20220130179A
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KR
South Korea
Prior art keywords
btk inhibitor
lesions
dose
weeks
multiple sclerosis
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Pending
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KR1020227028409A
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English (en)
Korean (ko)
Inventor
미형 조
티모시 제이. 터너
에릭 발스트룀
Original Assignee
젠자임 코포레이션
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Application filed by 젠자임 코포레이션 filed Critical 젠자임 코포레이션
Publication of KR20220130179A publication Critical patent/KR20220130179A/ko
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020227028409A 2020-01-20 2021-01-19 재발성 다발성 경화증(rms)에 대한 치료용 티로신 키나제 저해제 Pending KR20220130179A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202062963238P 2020-01-20 2020-01-20
US62/963,238 2020-01-20
US202062970502P 2020-02-05 2020-02-05
US62/970,502 2020-02-05
US202063013895P 2020-04-22 2020-04-22
US63/013,895 2020-04-22
PCT/US2021/013883 WO2021150476A1 (en) 2020-01-20 2021-01-19 Therapeutic tyrosine kinase inhibitors for relapsing multiple sclerosis (rms)

Publications (1)

Publication Number Publication Date
KR20220130179A true KR20220130179A (ko) 2022-09-26

Family

ID=74626161

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020227028409A Pending KR20220130179A (ko) 2020-01-20 2021-01-19 재발성 다발성 경화증(rms)에 대한 치료용 티로신 키나제 저해제

Country Status (12)

Country Link
US (2) US11969418B2 (https=)
EP (1) EP4093397A1 (https=)
JP (2) JP2023510604A (https=)
KR (1) KR20220130179A (https=)
CN (1) CN115348862A (https=)
AU (1) AU2021209608A1 (https=)
BR (1) BR112022014058A2 (https=)
CA (1) CA3168146A1 (https=)
IL (1) IL294560A (https=)
MX (1) MX2022008875A (https=)
TW (1) TWI883107B (https=)
WO (1) WO2021150476A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112022014058A2 (pt) 2020-01-20 2022-09-13 Genzyme Corp Inibidores terapêuticos de tirosina cinase para esclerose múltipla recidivante (rms)
AU2021398051A1 (en) * 2020-12-10 2023-07-27 Principia Biopharma Inc. Crystal form of tolebrutinib, preparation method therefor and use thereof
EP4328226A4 (en) * 2021-04-23 2025-08-27 Hangzhou Solipharma Co Ltd CRYSTALLINE FORM, AMORPHOUS FORM OF TOLEBRUTINIB, PREPARATION PROCESS THEREOF AND USE THEREOF
CN117412749A (zh) * 2021-05-21 2024-01-16 杭州领业医药科技有限公司 Tolebrutinib盐及其晶型、其制备方法、其药物组合物和用途
WO2022257845A1 (zh) * 2021-06-11 2022-12-15 苏州科睿思制药有限公司 Tolebrutinib的晶型及其制备方法和用途
WO2023280132A1 (zh) * 2021-07-06 2023-01-12 苏州晶云药物科技股份有限公司 氧代二氢咪唑并吡啶类化合物的晶型及其制备方法
CA3260159A1 (en) * 2022-06-30 2024-01-04 Principia Biopharma Inc. Therapeutic Tyrosine Kinase Inhibitors for the Treatment of Multiple Sclerosis and Myasthenia Gravis
EP4601647A1 (en) * 2022-10-11 2025-08-20 Principia Biopharma Inc. Therapeutic tyrosine kinase inhibitors for multiple sclerosis
AU2023408758A1 (en) * 2022-12-20 2025-07-31 Principia Biopharma Inc. Drug formulations of (r)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4- phenoxyphenyl)-1h-imidazo[4,5-c]pyridin-2(3h)-one
JP2026505764A (ja) 2023-02-01 2026-02-18 プリンシピア バイオファーマ インコーポレイテッド 多発性硬化症を診断及び治療する方法
WO2025264860A2 (en) 2024-06-18 2025-12-26 Yale University Methods of treating post-covid airway disease

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BR112022014058A2 (pt) 2020-01-20 2022-09-13 Genzyme Corp Inibidores terapêuticos de tirosina cinase para esclerose múltipla recidivante (rms)
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AU2021398051A1 (en) 2020-12-10 2023-07-27 Principia Biopharma Inc. Crystal form of tolebrutinib, preparation method therefor and use thereof
EP4328226A4 (en) 2021-04-23 2025-08-27 Hangzhou Solipharma Co Ltd CRYSTALLINE FORM, AMORPHOUS FORM OF TOLEBRUTINIB, PREPARATION PROCESS THEREOF AND USE THEREOF

Also Published As

Publication number Publication date
WO2021150476A1 (en) 2021-07-29
TW202140002A (zh) 2021-11-01
EP4093397A1 (en) 2022-11-30
TWI883107B (zh) 2025-05-11
MX2022008875A (es) 2022-08-11
CA3168146A1 (en) 2021-07-29
US20240366585A1 (en) 2024-11-07
US20210244720A1 (en) 2021-08-12
CN115348862A (zh) 2022-11-15
US11969418B2 (en) 2024-04-30
JP2023510604A (ja) 2023-03-14
BR112022014058A2 (pt) 2022-09-13
IL294560A (en) 2022-09-01
AU2021209608A1 (en) 2022-09-15
JP2026001038A (ja) 2026-01-06

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