CN115317396A - Blue copper peptide composition, preparation method thereof and cosmetics - Google Patents
Blue copper peptide composition, preparation method thereof and cosmetics Download PDFInfo
- Publication number
- CN115317396A CN115317396A CN202211159800.9A CN202211159800A CN115317396A CN 115317396 A CN115317396 A CN 115317396A CN 202211159800 A CN202211159800 A CN 202211159800A CN 115317396 A CN115317396 A CN 115317396A
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- China
- Prior art keywords
- phase
- mixture
- composition
- water
- pentanediol
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 163
- 241000530268 Lycaena heteronea Species 0.000 title claims abstract description 61
- MVORZMQFXBLMHM-QWRGUYRKSA-N Gly-His-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)CN)CC1=CN=CN1 MVORZMQFXBLMHM-QWRGUYRKSA-N 0.000 title claims abstract description 58
- 239000002537 cosmetic Substances 0.000 title claims abstract description 14
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 99
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 77
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 68
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims abstract description 66
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 claims abstract description 52
- 229940015975 1,2-hexanediol Drugs 0.000 claims abstract description 46
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims abstract description 46
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 claims abstract description 40
- 239000001509 sodium citrate Substances 0.000 claims abstract description 33
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims abstract description 33
- -1 glycerol glucoside Chemical class 0.000 claims abstract description 28
- 239000000047 product Substances 0.000 claims abstract description 22
- CCOQPGVQAWPUPE-UHFFFAOYSA-N 4-tert-butylcyclohexan-1-ol Chemical compound CC(C)(C)C1CCC(O)CC1 CCOQPGVQAWPUPE-UHFFFAOYSA-N 0.000 claims abstract description 20
- 229940091886 4-tert-butylcyclohexanol Drugs 0.000 claims abstract description 20
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 claims abstract description 20
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 claims abstract description 20
- 235000007164 Oryza sativa Nutrition 0.000 claims abstract description 20
- 235000010385 ascorbyl palmitate Nutrition 0.000 claims abstract description 20
- 229960000735 docosanol Drugs 0.000 claims abstract description 20
- 238000000855 fermentation Methods 0.000 claims abstract description 20
- 230000004151 fermentation Effects 0.000 claims abstract description 20
- 239000000706 filtrate Substances 0.000 claims abstract description 20
- 229930182478 glucoside Natural products 0.000 claims abstract description 20
- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims abstract description 20
- 235000009566 rice Nutrition 0.000 claims abstract description 20
- 229940080352 sodium stearoyl lactylate Drugs 0.000 claims abstract description 20
- ODFAPIRLUPAQCQ-UHFFFAOYSA-M sodium stearoyl lactylate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC(=O)OC(C)C(=O)OC(C)C([O-])=O ODFAPIRLUPAQCQ-UHFFFAOYSA-M 0.000 claims abstract description 20
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims abstract description 19
- 229920002307 Dextran Polymers 0.000 claims abstract description 18
- KIUVQMGRTDPAFR-UHFFFAOYSA-N benzoic acid 2-hydroxy-2-phenylpropanamide Chemical compound C(C1=CC=CC=C1)(=O)O.OC(C(=O)N)(C)C1=CC=CC=C1 KIUVQMGRTDPAFR-UHFFFAOYSA-N 0.000 claims abstract description 17
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 claims abstract description 15
- UIVPNOBLHXUKDX-UHFFFAOYSA-N 3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate Chemical compound CC(C)(C)CC(C)CCOC(=O)CC(C)CC(C)(C)C UIVPNOBLHXUKDX-UHFFFAOYSA-N 0.000 claims abstract description 13
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims abstract description 13
- 239000004475 Arginine Substances 0.000 claims abstract description 13
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims abstract description 13
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 13
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000010949 copper Substances 0.000 claims abstract description 13
- 229910052802 copper Inorganic materials 0.000 claims abstract description 13
- 229920006037 cross link polymer Polymers 0.000 claims abstract description 13
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims abstract description 13
- 239000004205 dimethyl polysiloxane Substances 0.000 claims abstract description 13
- 229940100554 isononyl isononanoate Drugs 0.000 claims abstract description 13
- 229940078812 myristyl myristate Drugs 0.000 claims abstract description 13
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims abstract description 13
- DZKXJUASMGQEMA-UHFFFAOYSA-N tetradecyl tetradecanoate Chemical compound CCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCC DZKXJUASMGQEMA-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000000230 xanthan gum Substances 0.000 claims abstract description 13
- 229920001285 xanthan gum Polymers 0.000 claims abstract description 13
- 229940082509 xanthan gum Drugs 0.000 claims abstract description 13
- 235000010493 xanthan gum Nutrition 0.000 claims abstract description 13
- DRRMRHKHTQRWMB-UHFFFAOYSA-N [3-(2-ethylhexanoyloxy)-2,2-bis(2-ethylhexanoyloxymethyl)propyl] 2-ethylhexanoate Chemical compound CCCCC(CC)C(=O)OCC(COC(=O)C(CC)CCCC)(COC(=O)C(CC)CCCC)COC(=O)C(CC)CCCC DRRMRHKHTQRWMB-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229940008099 dimethicone Drugs 0.000 claims abstract description 10
- 238000000034 method Methods 0.000 claims abstract description 10
- AEIJTFQOBWATKX-UHFFFAOYSA-N octane-1,2-diol Chemical compound CCCCCCC(O)CO AEIJTFQOBWATKX-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229940081733 cetearyl alcohol Drugs 0.000 claims abstract description 6
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims abstract description 5
- 229960003121 arginine Drugs 0.000 claims abstract description 4
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 40
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 37
- 239000007788 liquid Substances 0.000 claims description 32
- 239000002994 raw material Substances 0.000 claims description 26
- 238000010438 heat treatment Methods 0.000 claims description 23
- 241000209094 Oryza Species 0.000 claims description 19
- 230000001804 emulsifying effect Effects 0.000 claims description 12
- 238000001816 cooling Methods 0.000 claims description 10
- 238000005086 pumping Methods 0.000 claims description 10
- GLZWNFNQMJAZGY-UHFFFAOYSA-N octaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCOCCOCCO GLZWNFNQMJAZGY-UHFFFAOYSA-N 0.000 claims description 8
- 229910000906 Bronze Inorganic materials 0.000 claims description 7
- 239000010974 bronze Substances 0.000 claims description 7
- 229940082500 cetostearyl alcohol Drugs 0.000 claims description 7
- KUNSUQLRTQLHQQ-UHFFFAOYSA-N copper tin Chemical compound [Cu].[Sn] KUNSUQLRTQLHQQ-UHFFFAOYSA-N 0.000 claims description 7
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 claims description 7
- 230000008859 change Effects 0.000 claims description 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 2
- 238000004382 potting Methods 0.000 claims 1
- 238000002845 discoloration Methods 0.000 abstract description 3
- 240000007594 Oryza sativa Species 0.000 abstract 1
- 238000003756 stirring Methods 0.000 description 23
- 238000012360 testing method Methods 0.000 description 9
- 230000037303 wrinkles Effects 0.000 description 6
- 230000003712 anti-aging effect Effects 0.000 description 5
- SHZIWNPUGXLXDT-UHFFFAOYSA-N ethyl hexanoate Chemical compound CCCCCC(=O)OCC SHZIWNPUGXLXDT-UHFFFAOYSA-N 0.000 description 4
- 238000001914 filtration Methods 0.000 description 4
- 238000004321 preservation Methods 0.000 description 4
- 230000009467 reduction Effects 0.000 description 4
- VKIJBOMCWLTQBD-UHFFFAOYSA-N benzoic acid N-(2-hydroxyphenyl)propanamide Chemical compound C(C1=CC=CC=C1)(=O)O.C(CC)(=O)NC1=C(C=CC=C1)O VKIJBOMCWLTQBD-UHFFFAOYSA-N 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
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- 239000002253 acid Substances 0.000 description 2
- 238000007599 discharging Methods 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 238000000265 homogenisation Methods 0.000 description 2
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- 230000008439 repair process Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- RWLALWYNXFYRGW-UHFFFAOYSA-N 2-Ethyl-1,3-hexanediol Chemical compound CCCC(O)C(CC)CO RWLALWYNXFYRGW-UHFFFAOYSA-N 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
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- 230000032683 aging Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
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- 229960005082 etohexadiol Drugs 0.000 description 1
- 238000005562 fading Methods 0.000 description 1
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- OEIJHBUUFURJLI-UHFFFAOYSA-N octane-1,8-diol Chemical compound OCCCCCCCCO OEIJHBUUFURJLI-UHFFFAOYSA-N 0.000 description 1
- 125000002801 octanoyl group Chemical group C(CCCCCCC)(=O)* 0.000 description 1
- 239000005022 packaging material Substances 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- NFHFRUOZVGFOOS-UHFFFAOYSA-N palladium;triphenylphosphane Chemical compound [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 NFHFRUOZVGFOOS-UHFFFAOYSA-N 0.000 description 1
- 229940059574 pentaerithrityl Drugs 0.000 description 1
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
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Classifications
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- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8158—Homopolymers or copolymers of amides or imides, e.g. (meth) acrylamide; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The application relates to the field of cosmetics, and relates to a blue copper peptide composition, a preparation method thereof and cosmetics. The method comprises the following steps: glycerol, 1,2-pentanediol, 1,2-hexanediol, caprylyl glycol, xanthan gum, acrylic/C10-30 alkanol acrylate crosspolymer, behenyl alcohol, polyglyceryl-10 pentastearate, sodium stearoyl lactylate, cetearyl alcohol, myristyl myristate, dimethicone, pentaerythritol tetra (ethyl hexanoate), isononyl isononanoate, 4-tert-butyl cyclohexanol, arginine, butylene glycol, hydroxyphenylpropionamide benzoic acid, ascorbyl palmitate, palmitoyl tripeptide-8, rice fermentation product filtrate, citric acid, sodium citrate, p-hydroxyacetophenone, dextran, glycerol glucoside, tripeptide-1 copper, and water. The heat resistance at 45 ℃ is 3 months, the cold resistance at 18 ℃ is 3 months, after the room temperature is recovered, the serious discoloration and thinning conditions do not occur, and the texture is still the same as that of the standard sample.
Description
Technical Field
The application relates to the field of cosmetics, in particular to a blue copper peptide composition, a preparation method thereof and cosmetics.
Background
The bluecopper peptide can promote the regeneration of collagen and elastin, promote normal generation of ECM by skin, promote the repair capability of skin, and has the functions of anti-inflammation and antioxidation.
However, the use of the blue copper peptide is limited. The blue copper peptide reacts with many components, resulting in product instability. For example, the blue copper peptide cannot be compatible with caprylyl hydroximic acid and EDTA-2NA, and has the risks of precipitation and discoloration; it cannot be used with strong acid, strong alkaline substance, basic amino compound, and peroxide.
At present, the blue copper peptide cosmetics are rarely seen on the market.
Disclosure of Invention
The embodiment of the application aims to provide a blue copper peptide composition, a preparation method thereof and a cosmetic, and the blue copper peptide composition is good in stability.
In a first aspect, the present application provides a composition of a blue copopeptide comprising the following components:
glycerol, 1,2-pentanediol, 1,2-hexanediol, caprylyl glycol, xanthan gum, acrylic/C10-30 alkanol acrylate crosspolymer, behenyl alcohol, polyglyceryl-10 pentastearate, sodium stearoyl lactylate, cetearyl alcohol, myristyl myristate, dimethicone, pentaerythritol tetra (ethyl hexanoate), isononyl isononanoate, 4-tert-butyl cyclohexanol, arginine, butylene glycol, hydroxyphenylpropionamide benzoic acid, ascorbyl palmitate, palmitoyl tripeptide-8, rice fermentation product filtrate, citric acid, sodium citrate, p-hydroxyacetophenone, dextran, glycerol glucoside, tripeptide-1 copper, and water.
The composition of the present invention can form a stable cosmetic. And can be used as a stable packing material for frost.
Furthermore, the viscosity of the copper-clad composite is 26830mpa.s or more, and the copper-clad composite can be stably used as a packaging material of frost. The bluecopper peptide composition can resist heat at 45 ℃ for 3 months, does not become thin after the room temperature is recovered, and has the same texture as a standard sample; the product is cold-resistant at-18 ℃ for 3 months, does not have serious discoloration and thinning after being returned to room temperature, and has the same texture as the standard sample.
Furthermore, the blue copper peptide composition has excellent performance of repairing skin barrier and resisting aging.
In other embodiments of the present application, the above-described bluepatin peptide composition, comprises at least one of the following features (1) - (8):
(1) 1,2 hexanediol and octaethylene glycol in admixture as components of a composition of a blue copper peptide;
(2) Behenyl alcohol, polyglycerol-10 pentastearate and sodium stearoyl lactylate as components of the blue copper peptide composition in the form of a mixture;
(3) 4-tert-butylcyclohexanol and 1,2-pentanediol in the form of a mixture as components of a composition of blue copper peptides;
(4) As components of the composition of the blue copper peptide, hydroxyphenyl propionamide benzoic acid, ascorbyl palmitate in admixture with butanediol, 1,2-pentanediol;
(5) Palmitoyl tripeptide-8, water and butanediol in a mixture as a component of the bronze peptide composition;
(6) The rice fermentation product filtrate, butanediol, citric acid, sodium citrate, 1,2-hexanediol and p-hydroxyacetophenone are used as components of the composition of the blue copper peptide in the form of a mixture;
(7) Dextran, butylene glycol, p-hydroxyacetophenone, 1,2-hexanediol, sodium citrate, citric acid, and water in the form of a mixture as components of the composition of the blue copper peptide;
(8) Glyceryl glucoside, water, and 1,2-pentanediol were used as components of the composition of the blueprints in the form of a mixture.
In other embodiments of the present application, the above-mentioned composition of the blue copper peptide comprises, in percent by mass:
1-10% glycerol, 1-5%1, 2-pentanediol, 0.1-1%1, 2-hexanediol and octylene glycol mixture, 0.01-1% xanthan gum, 0.1-0.5% acrylic/C10-30 alkanol acrylate crosspolymer, 1-5% behenyl alcohol, polyglycerol-10 pentastearate and sodium stearoyl lactylate mixture, 1-3% cetostearyl alcohol, 0.5-2% myristyl myristate, 1-4% dimethicone, 1-5% pentaerythritol tetrakis (ethyl hexanoate), 1-10% isononyl isononanoate, 0.1-1%1, 2-pentanediol and 4-tert-butylcyclohexanol mixture; 0.1-0.5% arginine, 0.1% -0.5% butanediol, 1,2-pentanediol, a hydroxyphenylpropionamide benzoic acid and ascorbyl palmitate mixture, 1% -5% palmitoyl tripeptide-8, a water and butanediol mixture, 0.1-2% rice fermentation product filtrate, butanediol, citric acid, sodium citrate, 1,2-hexanediol and p-hydroxyacetophenone mixture, 0.1-2% butanediol, dextran, p-hydroxyacetophenone, 1,2-hexanediol, sodium citrate, citric acid and water mixture, 0.001-1% glycerol glucoside, water and 1,2-pentanediol mixture, 0.001-1% tripeptide-1 copper; the balance being water.
In other embodiments of the present application, the above-described blueprint peptide composition has a pH in the range of 6-7.
In other embodiments herein, the viscosity of the above-described bluepatin peptide composition is greater than 20000mpa.s.
In other embodiments of the present application, the stability of the above-described blueprint peptide composition comprises: the sample is kept for three months in the environment of 45 ℃ and has no obvious change compared with a normal temperature sample;
the sample is kept for three months in the environment of 18 ℃ below zero and has no obvious change compared with the normal temperature sample.
In a second aspect, the present application provides a method of preparing a composition of a blue-green peptide, the blue-green peptide composition comprising:
phase A: glycerol, 1,2-pentanediol, 1,2-hexanediol, octaglycerol, xanthan gum, acrylic/C10-30 alkanol acrylate crosspolymer, and water;
phase B: behenyl alcohol, polyglyceryl-10 pentastearate, sodium stearoyl lactylate, cetostearyl alcohol, myristyl myristate, dimethicone, pentaerythritol tetrakis (ethyl hexanoate), isononyl isononanoate, 4-tert-butylcyclohexanol;
and C phase: arginine, water;
phase D: butylene glycol, hydroxyphenylpropionamide benzoic acid, ascorbyl palmitate, palmitoyl tripeptide-8, rice fermentation product filtrate, citric acid, sodium citrate, p-hydroxyacetophenone, dextran, glycerol glucoside;
phase E: tripeptide-1 copper, water;
the preparation method comprises the following steps:
adding the phase A raw material into a water phase pot, heating and preserving heat to obtain a first liquid;
adding the phase B raw material into an oil phase pot, heating and preserving heat to obtain second liquid;
pumping the first liquid and the second liquid into an emulsifying pot for homogenizing to obtain a third liquid;
adding the phase C into the third liquid, homogenizing and cooling to obtain a fourth liquid;
and adding the D phase and the E phase into the fourth liquid.
In other embodiments of the present application, the phase a raw material is added into the water phase pot, and the heating and the heat preservation are carried out, wherein the heating is carried out to 80 ℃ to 90 ℃, and the heat preservation time is 10min to 30min; and/or
Adding the phase B raw material into an oil phase pot, heating and preserving heat, wherein the heating is carried out to 75-85 ℃, and the preserving time is 5-20 min.
In other embodiments of the present application, the pumping the first liquid and the second liquid into the emulsifying pot for homogenizing includes: homogenizing at 2000-4000rpm for 2-8 min; and/or
Adding phase C into the third solution, homogenizing, and cooling to 40-50 deg.C.
In a third aspect, the present application provides a cosmetic comprising the composition of a blue copper peptide of any one of the preceding; or a method of making a copper-peptide composition according to any of the preceding claims.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions of the embodiments of the present application will be clearly and completely described below, and it is obvious that the described embodiments are some embodiments of the present application, but not all embodiments.
Thus, the following detailed description of the embodiments of the present application is not intended to limit the scope of the claimed application, but is merely representative of selected embodiments of the application. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
The embodiment of the application provides a blue copper peptide composition, which comprises the following components:
glycerol, 1,2-pentanediol, 1,2-hexanediol, caprylyl glycol, xanthan gum, acrylic/C10-30 alkanol acrylate crosspolymer, behenyl alcohol, polyglyceryl-10 pentastearate, sodium stearoyl lactylate, cetearyl alcohol, myristyl myristate, dimethicone, pentaerythritol tetra (ethyl hexanoate), isononyl isononanoate, 4-tert-butyl cyclohexanol, arginine, butylene glycol, hydroxyphenylpropionamide benzoic acid, ascorbyl palmitate, palmitoyl tripeptide-8, rice fermentation product filtrate, citric acid, sodium citrate, p-hydroxyacetophenone, dextran, glycerol glucoside, tripeptide-1 copper, and water.
Further, in some embodiments herein, the above-described composition of the blue copper peptide comprises at least one of the following features (1) - (8):
(1) 1,2 hexanediol and octaethylene glycol in admixture as components of a composition of a bluecopper peptide;
(2) Behenyl alcohol, polyglycerol-10 pentastearate and sodium stearoyl lactylate as components of the blue copper peptide composition in the form of a mixture;
(3) 4-tert-butylcyclohexanol and 1,2-pentanediol in admixture as components of a bluecopper peptide composition;
(4) Hydroxyphenylpropionamide benzoic acid, ascorbyl palmitate in admixture with butylene glycol, 1,2-pentanediol as components of a blue copper peptide composition;
(5) Palmitoyl tripeptide-8, water and butanediol in a mixture as a component of the bronze peptide composition;
(6) The rice fermentation product filtrate, butanediol, citric acid, sodium citrate, 1,2-hexanediol and p-hydroxyacetophenone are used as components of the composition of the blue copper peptide in the form of a mixture;
(7) Dextran, butylene glycol, p-hydroxyacetophenone, 1,2-hexanediol, sodium citrate, citric acid, and water in the form of a mixture as components of the composition of the blue copper peptide;
(8) Glycerol glucoside, water, and 1,2-pentanediol were in the form of a mixture as components of the composition of the blue copper peptide.
Further, in some embodiments herein, in the aforementioned feature (1), 1,2-hexanediol and octaethylene glycol are in a mixture as components of the composition of the blue copper peptide; wherein, when 1,2-hexanediol and caprylyl glycol are mixed, 1,2-hexanediol is 40-60% and caprylyl glycol is 60-40% according to mass fraction. Illustratively, 1,2-hexanediol, 50%, octaethylene glycol, 50%.
Further, in some embodiments herein, in the aforementioned feature (2), the behenyl alcohol, the polyglyceryl-10 pentastearate, and the sodium stearoyl lactylate are in a form of a mixture as components of the blue copper peptide composition; wherein, when the behenyl alcohol, the polyglycerol-10 pentastearate and the sodium stearoyl lactylate are mixed, the mass fraction of the behenyl alcohol is 45-50%, the mass fraction of the polyglycerol-10 pentastearate is 35-40%, and the mass fraction of the sodium stearoyl lactylate is 10-15%. Illustratively, behenyl alcohol 50%, polyglyceryl-10 pentastearate 38%, sodium stearoyl lactylate 12%.
Further, in some embodiments herein, in the aforementioned feature (3), the 4-tert-butylcyclohexanol and 1,2-pentanediol are in the form of a mixture as components of the bronze peptide composition; wherein, when the 4-tert-butylcyclohexanol and 1,2-pentanediol are mixed, the 4-tert-butylcyclohexanol accounts for 35-40% by mass; 1,2-pentanediol 60-65%. Exemplary, 4-tert-butylcyclohexanol 37.5%;1,2-pentanediol 62.5%.
Further, in some embodiments herein, in the aforementioned feature (4), the hydroxyphenylpropionamide benzoic acid, ascorbyl palmitate, and the butanediol, 1,2-pentanediol, are in a mixture as components of the bronze peptide composition; wherein, when the hydroxyphenyl propionamide benzoic acid and the ascorbyl palmitate are mixed with butanediol and 1,2-pentanediol, the hydroxyphenyl propionamide benzoic acid accounts for 4 to 10 percent and the ascorbyl palmitate accounts for 0.05 to 0.2 percent according to the mass fraction; 40-46% of butanediol and 45-50% of 1,2-pentanediol. Illustratively, hydroxyphenylpropionamide benzoic acid (5%), ascorbyl palmitate (0.1%), butanediol (44.9%), 1,2-pentanediol (50%).
Further, in some embodiments herein, in the aforementioned feature (5), the palmitoyl tripeptide-8, water, and butanediol are in a mixture as components of the composition of the blue copper peptide; wherein, when the palmitoyl tripeptide-8, the water and the butanediol are mixed, the palmitoyl tripeptide-8.01 to 0.04 percent, the water 23.5 to 27 percent and the butanediol 72.96 to 76.49 percent are mixed according to the mass fraction. Illustratively, palmitoyl tripeptide-8.03%, water 24.97%, butanediol 75%.
Further, in some embodiments herein, in the aforementioned feature (6), the rice fermentation product filtrate, butanediol, citric acid, sodium citrate, 1,2-hexanediol, and p-hydroxyacetophenone are in the form of a mixture as a component of the composition for a bluecopper peptide; wherein when the rice fermentation product filtrate, butanediol, citric acid, sodium citrate, 1,2-hexanediol and p-hydroxyacetophenone are mixed, according to the mass fraction, the rice fermentation product filtrate is 87-91%, the butanediol is 8-12%, the citric acid is 0.01-0.03%, the sodium citrate is 0.05-0.10%, the 1,2-hexanediol is 0.4-0.8%, and the p-hydroxyacetophenone is 0.3-0.8%. Illustratively, the rice fermentation product filtrate is 88.8%, butanediol 10%, citric acid 0.02%, sodium citrate 0.08%, 1,2-hexanediol 0.6%, p-hydroxyacetophenone 0.5%.
Further, in some embodiments herein, in the aforementioned feature (7), the dextran, the butylene glycol, the p-hydroxyacetophenone, the 1,2-hexanediol, the sodium citrate, the citric acid, and the water are in the form of a mixture as a component of the composition for a bluecopper peptide; when glucan, butanediol, p-hydroxyacetophenone, 1,2-hexanediol, sodium citrate, citric acid and water are mixed, the glucan is 0.3-0.5 percent, the butanediol is 4-8 percent, the p-hydroxyacetophenone is 0.2-0.8 percent, the 1,2-hexanediol is 0.2-0.8 percent, the sodium citrate is 0.01-0.05 percent, the citric acid is 0.01-0.05 percent and the water is 90-95 percent according to the mass fraction. Illustratively, dextran 0.47%, butylene glycol 6%, p-hydroxyacetophenone 0.5%, 1,2-hexanediol 0.5%, sodium citrate 0.04%, citric acid 0.02%, water 92.47%.
Further, in some embodiments of the present application, in the aforementioned feature (8), the glycerol glucoside, the water, and the 1,2-pentanediol are in the form of a mixture as a component of the composition for the bluecopper peptide. When the glycerol glucoside, the water and the 1,2-pentanediol are mixed, the glycerol glucoside accounts for 40-50 percent, the water accounts for 45-55 percent and the 1,2-pentanediol accounts for 1-5 percent according to mass fraction. Illustratively, 45% glycerol glucoside, 50% water, 1,2-pentanediol 5%.
Further, in some embodiments of the present application, the above-described blueprint peptide composition comprises:
glycerol, 1,2-pentanediol, 1,2-hexanediol and octaethylene glycol mixture, xanthan gum, acrylic/C10-30 alkanol acrylate crosspolymer, behenyl alcohol, polyglyceryl-10 pentastearate and sodium stearoyl lactylate mixture, cetearyl alcohol, myristyl myristate, dimethicone, pentaerythritol tetra (ethylhexanoate), isononyl isononanoate, 1,2-pentanediol and 4-tert-butylcyclohexanol mixture; arginine, butylene glycol, 1,2-pentanediol, hydroxyphenylpropionamide benzoic acid and ascorbyl palmitate mixture, palmitoyl tripeptide-8, water and butylene glycol mixture, rice fermentation product filtrate, butylene glycol, citric acid, sodium citrate, 1,2-hexanediol and p-hydroxyacetophenone mixture, butylene glycol, dextran, p-hydroxyacetophenone, 1,2-hexanediol, sodium citrate, citric acid and water mixture, glycerol glucoside, water and 1,2-pentanediol mixture, tripeptide-1 copper; the balance being water.
Further, in some embodiments of the present application, the above-mentioned composition of the blue copper peptide comprises, by mass percent:
1-10% glycerol, 1-5%1, 2-pentanediol, 0.1-1%1, 2-hexanediol and octaethylene glycol mixture, 0.01-1% xanthan gum, 0.1-0.5% acrylic/C10-30 alkanol acrylate crosspolymer, 1-5% behenyl alcohol, polyglycerol-10 pentastearate and sodium stearoyl lactylate mixture, 1-3% cetostearyl alcohol, 0.5-2% myristyl myristate, 1-4% polydimethylsiloxane, 1-5% pentaerythritol tetrakis (ethyl hexanoate), 1-10% isononyl isononanoate, 0.1-1%1, 2-pentanediol and 4-tert-butylcyclohexanol mixture; 0.1-0.5% arginine, 0.1-0.5% butanediol, 1,2-pentanediol, hydroxyphenylpropionamide benzoic acid and ascorbyl palmitate mixture, 1-5% palmitoyl tripeptide-8, water and butanediol mixture, 0.1-2% rice fermentation product filtrate, butanediol, citric acid, sodium citrate, 1,2-hexanediol and p-hydroxyacetophenone mixture, 0.1-2% butanediol, dextran, p-hydroxyacetophenone, 1,2-hexanediol, sodium citrate, citric acid and water mixture, 0.001-1% glycerol glucoside, water and 1,2-pentanediol mixture, 0.001-1% tripeptide-1 copper; the balance being water.
Further optionally, in some embodiments of the present application, the above-mentioned composition of the blue copper peptide comprises, by mass percent:
1.5-9.5% glycerol, 1.5-4.5%1, 2-pentanediol, 0.2-0.9%1, 2-hexanediol and caprylyl glycol mixture, 0.05-0.9% xanthan gum, 0.15-0.45% acrylic/C10-30 alkanol acrylate crosspolymer, 1.5-4.5% behenyl alcohol, a mixture of polyglyceryl-10 pentastearate and sodium stearoyl lactylate, 1.5-2.5% cetostearyl alcohol, 1-1.9% myristyl myristate, 1.5-3.5% dimethicone, 1.5-4.5% pentaerythrityl tetrakis (ethyl hexanoate), 1.5-9.5% isononyl isononanoate, 0.2-0.9%1, 2-pentanediol and 4-tert-butylcyclohexanol mixture; 0.15-0.45% arginine, 0.15% -0.45% butanediol, 1,2-pentanediol, a hydroxyphenylpropionamide benzoic acid and ascorbyl palmitate mixture, 1.5% -4.5% palmitoyl tripeptide-8, a water and butanediol mixture, 0.15-1.9% rice fermentation product filtrate, butanediol, citric acid, sodium citrate, 1,2-hexanediol and p-hydroxyacetophenone mixture, 0.11-1.9% butanediol, dextran, p-hydroxyacetophenone, 1,2-hexanediol, sodium citrate, citric acid and water mixture, 0.005-0.9% glycerol glucoside, water and 1,2-pentanediol mixture, 0.005-0.99% tripeptide-1 copper; the balance being water.
Illustratively, in some embodiments herein, the above-described composition of the blue-green peptide comprises, in percent by mass:
2%, 3%, 4%, 5%, 6%, 7%, 8% or 9% glycerol;
1.5%, 2%, 2.5%, 3%, 3.5% or 4% by weight of 1, 2-pentanediol;
0.4%, 0.5%, 0.6%, 0.7%, or 0.8% of a 1,2-hexanediol and octanediol mixture;
0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7% or 0.8% xanthan gum;
0.2%, 0.25%, 0.3%, 0.35% or 0.4% acrylic/C10-30 alkanol acrylate crosspolymer;
2%, 2.5%, 3%, 3.5% or 4% of a blend of behenyl alcohol, polyglyceryl-10 pentastearate and sodium stearoyl lactylate;
1.6%, 1.8%, 2%, 2.2% or 2.4% cetearyl alcohol;
1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7% or 1.8% myristyl myristate;
1.8%, 2%, 2.5% or 3% polydimethylsiloxane;
1.8%, 2%, 2.5%, 3%, 3.5% or 4% pentaerythritol tetrakis (ethyl hexanoate);
2%, 3%, 4%, 5%, 6%, 7%, 8% or 9% isononyl isononanoate;
0.3%, 0.4%, 0.5%, 0.6%, 0.7% or 0.8% of a mixture of 1, 2-pentanediol and 4-tert-butylcyclohexanol;
0.18%, 0.2%, 0.2.5%, 0.3%, 0.35% or 0.4% arginine;
0.18%, 0.2%, 0.2.5%, 0.3%, 0.35% or 0.4% butanediol, 1,2-pentanediol, hydroxyphenylpropionamide benzoic acid, and ascorbyl palmitate mixtures;
2.5%, 3%, 3.5% or 4% palmitoyl tripeptide-8, water and butanediol mixture;
0.18%, 0.5%, 0.8%, 1%, 1.5% or 1.8% rice fermentation product filtrate, butylene glycol, citric acid, sodium citrate, 1,2-hexanediol and p-hydroxyacetophenone mixture;
0.11%, 0.5%, 0.8%, 1% or 1.5% butanediol, dextran, p-hydroxyacetophenone, 1,2-hexanediol, sodium citrate, citric acid, and water mixture;
0.008%, 0.01%, 0.05%, 0.1%, 0.5% or 0.9% glycerol glucoside, water and 1,2-pentanediol mixture;
0.008%, 0.01%, 0.05%, 0.1%, 0.5%, or 0.9% tripeptide-1 copper;
the contents of the raw materials are randomly selected and combined, and the balance is water.
Further, in some embodiments herein, the blue copper peptide composition has a pH in the range of 6 to 7.
Further, in some embodiments herein, the viscosity of the blueprint peptide composition is greater than 20000mpa.s.
Further, in some embodiments herein, the stability of the composition of the blueprint peptide comprises: the sample is kept for three months in the environment of 45 ℃ and has no obvious change compared with a normal temperature sample;
compared with a normal temperature sample, the sample has no obvious change in the environment of 18 ℃ below zero.
Some embodiments of the present application provide a method of preparing a blue copopeptide composition, the blue copopeptide composition comprising:
phase A: glycerol, 1,2-pentanediol, 1,2-hexanediol, octaglycerol, xanthan gum, acrylic/C10-30 alkanol acrylate crosspolymer, and water;
phase B: behenyl alcohol, polyglyceryl-10 pentastearate, sodium stearoyl lactylate, cetostearyl alcohol, myristyl myristate, dimethicone, pentaerythritol tetrakis (ethyl hexanoate), isononyl isononanoate, 4-tert-butylcyclohexanol;
and C phase: arginine, water;
phase D: butylene glycol, hydroxyphenylpropionamide benzoic acid, ascorbyl palmitate, palmitoyl tripeptide-8, rice fermentation product filtrate, citric acid, sodium citrate, p-hydroxyacetophenone, dextran, glycerol glucoside;
phase E: tripeptide-1 copper, water;
the preparation method comprises the following steps:
adding the phase A raw material into a water phase pot, heating and preserving heat to obtain a first liquid;
adding the B-phase raw material into an oil phase pot, heating and preserving heat to obtain second liquid;
pumping the first liquid and the second liquid into an emulsifying pot for homogenizing to obtain a third liquid;
adding the phase C into the third liquid, homogenizing and cooling to obtain a fourth liquid;
and adding the D phase and the E phase into the fourth liquid.
Further, in some embodiments of the present application, the phase a raw material is added into a water phase pot, and the heating and the heat preservation are carried out at 80 ℃ to 90 ℃ for 10min to 30min.
Further, in some embodiments of the present application, the phase B raw material is added into the oil phase pot, and the heating and the heat preservation are performed by heating to 75 ℃ to 85 ℃ for 5min to 20min.
Further, in some embodiments of the present application, pumping the first liquid and the second liquid into the emulsifying pan for homogenizing includes: the homogenizing speed is 2000-4000rpm, and the homogenizing time is 2-8 min.
Further, in some embodiments of the present disclosure, phase C is added to the third liquid, and the temperature is reduced to 40 ℃ to 50 ℃ after homogenization.
Illustratively, in some embodiments herein, a method of preparing a blueprint peptide composition comprises:
s1, adding the phase A raw materials into a water phase pot, starting stirring and heating to a certain temperature, and keeping the temperature and stirring for a certain period of time.
Further, in some embodiments of the present application, the stirring speed of the water kettle in step S1 is (500-1500) rpm; and heating to 80-90 ℃ for 10-30 min.
S2, adding the phase B raw materials into an oil phase pot, starting stirring and heating to a certain temperature, and keeping the temperature and stirring for a certain period of time.
The stirring speed in the step S2 is (500-1500) rpm; and heating to 75-85 ℃ for 5-20 min.
S3, pumping the phase A raw material into an emulsifying pot, starting stirring, pumping the phase B raw material, vacuumizing, starting external homogenizing for a certain period of time.
The stirring speed in the step S3 is (40-80) rpm; the vacuum is (0.01-0.06) Mpa, the homogenizing speed is 3000rpm, and the homogenizing time is (2-8) min.
S4, adding the completely dissolved C phase into an emulsifying pot, starting the emulsifying pot, homogenizing the mixture for a certain time, and reducing the stirring speed to a certain temperature.
And (4) homogenizing for 1-5 min, stirring and cooling to (30-50) rpm, and cooling to (40-50) DEG C.
And S5, adding the D-phase raw material and the E-phase raw material which are completely dissolved, uniformly stirring, cooling, filtering and discharging to obtain the composite material.
In step S5, the stirring speed is (30-50) rpm, the homogenizing time is (2-5) min, and the cooling temperature is (40-50) DEG C.
And step S5, the stirring speed is (30-50) rpm, the stirring time is (10-20) min, and 200-mesh filter cloth is used for filtering.
According to the method, through reasonably screening raw materials, some raw materials which can be matched with the blue copper peptide are screened, and the blue copper peptide composition with good stability and good repairing effect is finally screened.
Some embodiments of the present application provide a cosmetic comprising a composition of a blue-copper peptide provided in any of the preceding embodiments; or a method of making a composition according to any of the preceding embodiments.
The present application is described in detail below with reference to examples.
Example 1 and comparative examples 1 to 4
A composition of a blue copper peptide is provided, the composition of which is shown in Table 1.
TABLE 1
The preparation method comprises the following steps:
s1, adding the phase A raw materials into a water phase pot, starting stirring at the speed of 1000rpm, heating to 85 ℃, and keeping the temperature and stirring for 20min.
S2, adding the phase B raw materials into an oil phase pot, starting stirring at the speed of 1000rpm, heating to 80 ℃, and keeping the temperature and stirring for 10min.
S3, pumping the phase A raw material into an emulsifying pot, starting stirring at the stirring speed of 50rpm, pumping the phase B raw material, vacuumizing, starting homogenizing for 5min; the vacuum was-0.05 MPa, and the homogenization speed was 3000rpm.
S4, adding the completely dissolved C phase into an emulsifying pot, starting the emulsifying pot, homogenizing the mixture for 3min, and stirring the mixture until the stirring speed is reduced to 40rpm; the temperature is reduced to 45 ℃.
S5, adding the D phase and the E phase raw material which is completely dissolved, stirring at 40rpm for 15min, and homogenizing for 4min; cooling to 40 ℃; filtering, discharging, and filtering with 200 mesh filter cloth.
Experimental example 1
The physicochemical indexes and stability of the blue copper peptide compositions of example 1 and comparative examples 1 to 4 were tested.
The stability test method comprises the following steps:
and (3) filling each sample into 3 bottles, respectively placing the samples in a 45 ℃ oven and a-18 ℃ refrigerator for three months, taking out the samples every two weeks, standing the samples to room temperature, and observing the difference between the samples and the samples left at room temperature.
The results are shown in Table 2.
TABLE 2
From the physical and chemical indexes and stability results, the blue copper peptide composition in the embodiment 1 has good stability, can resist heat for 3 months at 45 ℃, is still the same as a standard sample after being recovered to room temperature, and can be accepted after fading slightly; cold resistance at-18 ℃ for 3 months, and the same standard sample after room temperature recovery.
Comparative examples 1 to 4, either low in viscosity, or slightly diluted, or poor in heat and cold stability, failed to form stable cosmetics, and were less suitable for the blue copper peptide cream.
Experimental example 2
Repairing and anti-aging efficacy test.
The composition of example 1 was used as a blue copper peptide cream cosmetic to test its repairing and anti-aging efficacy.
1. Repair skin barrier performance test
The test method comprises the following steps: the number of the test subjects is n =35, the trial time is 2 weeks, and the data in the table above is the average value of the corresponding indexes before trial, after 1 week of the test and after 2 weeks of the test; the TEWL value of the skin reflects the rate of the water loss of the deep layer of the skin through the skin, the better the barrier function of the skin is, the smaller the value is; the P value is less than or equal to 0.05, and the difference between the value before trial and the value after trial is considered to be significant.
The test results are shown in Table 3.
TABLE 3
As can be seen from Table 3, the P value of the blue copper peptide cream of the present application is less than 0.05, which indicates that the blue copper peptide composition of the present application has excellent skin barrier repairing performance.
2. Test for anti-aging Properties
The test method comprises the following steps:
the number of the tested subjects is n =35, the trial time is 4 weeks, and the data in the table is the average value of the corresponding indexes after 4 weeks of testing; as can be seen from the data, example 1 has an anti-aging effect.
The test results are shown in Table 4.
TABLE 4
Reduction of wrinkle area | Wrinkle depth reduction | Reduction of wrinkle count | |
Example 1 | 11.5% | 7.3% | 9.6% |
As can be seen from Table 4, the reduction of wrinkle area by 11.5%, wrinkle depth by 7.3%, and wrinkle number by 9.6% using the present composition indicates that the present composition is excellent in anti-aging properties.
The above description is only a preferred embodiment of the present application and is not intended to limit the present application, and various modifications and changes may be made to the present application by those skilled in the art. Any modification, equivalent replacement, improvement and the like made within the spirit and principle of the present application shall be included in the protection scope of the present application.
Claims (10)
1. A composition of a bluecopper peptide, comprising the following components:
glycerol, 1,2-pentanediol, 1,2-hexanediol, caprylyl glycol, xanthan gum, acrylic/C10-30 alkanol acrylate crosspolymer, behenyl alcohol, polyglyceryl-10 pentastearate, sodium stearoyl lactylate, cetearyl alcohol, myristyl myristate, dimethicone, pentaerythritol tetra (ethyl hexanoate), isononyl isononanoate, 4-tert-butyl cyclohexanol, arginine, butylene glycol, hydroxyphenylpropionamide benzoic acid, ascorbyl palmitate, palmitoyl tripeptide-8, rice fermentation product filtrate, citric acid, sodium citrate, p-hydroxyacetophenone, dextran, glycerol glucoside, tripeptide-1 copper, and water.
2. The bluecopper peptide composition according to claim 1, comprising at least one of the following features (1) - (8):
(1) The 1,2-hexanediol and the octaethylene glycol are in admixture as the components of the copper-blue peptide composition;
(2) Said behenyl alcohol, said polyglycerol-10 pentastearate, and said sodium stearoyl lactylate as a mixture as said components of said blue copper peptide composition;
(3) The 4-tert-butylcyclohexanol and the 1,2-pentanediol are in admixture as the components of the bronze peptide composition;
(4) Said hydroxyphenylpropionamide benzoic acid, said ascorbyl palmitate with said butanediol, said 1,2-pentanediol in admixture as said components of said blue copper peptide composition;
(5) The palmitoyl tripeptide-8, the water, and the butanediol are in a mixture as the components of the bronze peptide composition;
(6) The rice fermentation product filtrate, the butylene glycol, the citric acid, the sodium citrate, the 1,2-hexanediol, and the p-hydroxyacetophenone are in the form of a mixture as the components of the copper-blue peptide composition;
(7) The dextran, the butylene glycol, the p-hydroxyacetophenone, the 1,2-hexanediol, the sodium citrate, the citric acid, and water are in a mixture as the components of the bronze peptide composition;
(8) The glycerol glucoside, the water, and the 1,2-pentanediol are in a mixture as the components of the bluecopper peptide composition.
3. The composition of claim 2, comprising, in weight percent:
1-10% glycerol, 1-5%1, 2-pentanediol, 0.1-1%1, 2-hexanediol and octaethylene glycol mixture, 0.01-1% xanthan gum, 0.1-0.5% acrylic/C10-30 alkanol acrylate crosspolymer, 1-5% behenyl alcohol, polyglycerol-10 pentastearate and sodium stearoyl lactylate mixture, 1-3% cetostearyl alcohol, 0.5-2% myristyl myristate, 1-4% polydimethylsiloxane, 1-5% pentaerythritol tetrakis (ethyl hexanoate), 1-10% isononyl isononanoate, 0.1-1%1, 2-pentanediol and 4-tert-butylcyclohexanol mixture; 0.1-0.5% arginine, 0.1% -0.5% butanediol, 1,2-pentanediol, a hydroxyphenylpropionamide benzoic acid and ascorbyl palmitate mixture, 1% -5% palmitoyl tripeptide-8, a water and butanediol mixture, 0.1-2% rice fermentation product filtrate, butanediol, citric acid, sodium citrate, 1,2-hexanediol and p-hydroxyacetophenone mixture, 0.1-2% butanediol, dextran, p-hydroxyacetophenone, 1,2-hexanediol, sodium citrate, citric acid and water mixture, 0.001-1% glycerol glucoside, water and 1,2-pentanediol mixture, 0.001-1% tripeptide-1 copper; the balance being water.
4. The bluecopper peptide composition of any one of claims 1-3,
the pH value of the bluecopper peptide composition is in the range of 6-7.
5. The bluecopper peptide composition of any one of claims 1-3,
the viscosity of the bluepatin composition is more than 20000mpa.s.
6. The bluecopper peptide composition of any one of claims 1-3,
the stability of the bluecopper peptide composition comprises: the sample is kept for three months in the environment of 45 ℃ and has no obvious change compared with a normal temperature sample;
compared with a normal temperature sample, the sample has no obvious change in the environment of 18 ℃ below zero.
7. A method of preparing a composition of a copper-peptide, comprising:
phase A: glycerol, 1,2-pentanediol, 1,2-hexanediol, octaglycerol, xanthan gum, acrylic/C10-30 alkanol acrylate crosspolymer, and water;
phase B: behenyl alcohol, polyglyceryl-10 pentastearate, sodium stearoyl lactylate, cetostearyl alcohol, myristyl myristate, dimethicone, pentaerythritol tetrakis (ethyl hexanoate), isononyl isononanoate, 4-tert-butylcyclohexanol;
and C phase: arginine, water;
phase D: butylene glycol, hydroxyphenylpropionamide benzoic acid, ascorbyl palmitate, palmitoyl tripeptide-8, rice fermentation product filtrate, citric acid, sodium citrate, p-hydroxyacetophenone, dextran, glycerol glucoside;
phase E: tripeptide-1 copper, water;
the preparation method comprises the following steps:
adding the phase A raw material into a water phase pot, heating and preserving heat to obtain a first liquid;
adding the B-phase raw material into an oil phase pot, and heating and preserving heat to obtain a second liquid;
pumping the first liquid and the second liquid into an emulsifying pot for homogenizing to obtain a third liquid;
adding the phase C into the third liquid, homogenizing and cooling to obtain a fourth liquid;
adding said phase D and said phase E to said fourth liquid.
8. The method of preparing the composition of claim 7,
adding the phase A raw material into a water phase pot, heating and preserving heat, wherein the heating is carried out to 80-90 ℃, and the preserving heat duration is 10-30 min; and/or
And adding the phase B raw material into an oil phase pot, heating and preserving heat, wherein the heating is carried out to 75-85 ℃, and the preserving heat duration is 5-20 min.
9. The method of preparing a composition of claim 7,
the step of pumping the first liquid and the second liquid into an emulsifying pot for homogenizing comprises the following steps: homogenizing at 2000-4000rpm for 2-8 min; and/or
And adding the phase C into the third liquid, and cooling to 40-50 ℃ after homogenizing.
10. A cosmetic comprising the composition of the blue copper peptide according to any one of claims 1 to 6; or a composition of the blue-copper peptides produced by the method of any one of claims 7 to 9.
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN117126230A (en) * | 2023-10-23 | 2023-11-28 | 广州同隽医药科技有限公司 | Synthesis method and application of tripeptide-1 and blue copper peptide |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108514519A (en) * | 2018-05-11 | 2018-09-11 | 珠海伊斯佳科技股份有限公司 | A kind of skin care compositions and methods and its application method of whitening and anti-aging |
CN110302071A (en) * | 2019-06-18 | 2019-10-08 | 苏州绿叶日用品有限公司 | Blue light protection cosmetic composition and preparation method thereof and the cosmetics for including the composition |
FR3114025A1 (en) * | 2020-09-11 | 2022-03-18 | L'oreal | COSMETIC COMPOSITION COMPRISING STABILIZED RETINOL |
CN114732753A (en) * | 2022-03-28 | 2022-07-12 | 浙江宜格企业管理集团有限公司 | Blue copper peptide face cream and preparation method thereof |
CN114931530A (en) * | 2022-03-22 | 2022-08-23 | 广东丸美生物技术股份有限公司 | Skin care composition with anti-allergy and repairing effects, application thereof, cosmetic and method thereof |
-
2022
- 2022-09-22 CN CN202211159800.9A patent/CN115317396B/en active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108514519A (en) * | 2018-05-11 | 2018-09-11 | 珠海伊斯佳科技股份有限公司 | A kind of skin care compositions and methods and its application method of whitening and anti-aging |
CN110302071A (en) * | 2019-06-18 | 2019-10-08 | 苏州绿叶日用品有限公司 | Blue light protection cosmetic composition and preparation method thereof and the cosmetics for including the composition |
FR3114025A1 (en) * | 2020-09-11 | 2022-03-18 | L'oreal | COSMETIC COMPOSITION COMPRISING STABILIZED RETINOL |
CN114931530A (en) * | 2022-03-22 | 2022-08-23 | 广东丸美生物技术股份有限公司 | Skin care composition with anti-allergy and repairing effects, application thereof, cosmetic and method thereof |
CN114732753A (en) * | 2022-03-28 | 2022-07-12 | 浙江宜格企业管理集团有限公司 | Blue copper peptide face cream and preparation method thereof |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN117126230A (en) * | 2023-10-23 | 2023-11-28 | 广州同隽医药科技有限公司 | Synthesis method and application of tripeptide-1 and blue copper peptide |
CN117126230B (en) * | 2023-10-23 | 2024-02-13 | 广州同隽医药科技有限公司 | Synthesis method and application of tripeptide-1 and blue copper peptide |
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