CN115304977A - 控制、排斥和/或灭活病毒和细菌的pH/CO2响应性智能抗病原体涂层 - Google Patents
控制、排斥和/或灭活病毒和细菌的pH/CO2响应性智能抗病原体涂层 Download PDFInfo
- Publication number
- CN115304977A CN115304977A CN202210491960.7A CN202210491960A CN115304977A CN 115304977 A CN115304977 A CN 115304977A CN 202210491960 A CN202210491960 A CN 202210491960A CN 115304977 A CN115304977 A CN 115304977A
- Authority
- CN
- China
- Prior art keywords
- coating
- state
- bacteria
- hydrophilic
- hydrophobic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000576 coating method Methods 0.000 title claims abstract description 86
- 241000700605 Viruses Species 0.000 title claims abstract description 31
- 241000894006 Bacteria Species 0.000 title claims abstract description 24
- 230000002223 anti-pathogen Effects 0.000 title description 13
- 230000000415 inactivating effect Effects 0.000 title description 3
- 239000011248 coating agent Substances 0.000 claims abstract description 74
- 230000002209 hydrophobic effect Effects 0.000 claims abstract description 17
- 238000000034 method Methods 0.000 claims abstract description 17
- 230000002441 reversible effect Effects 0.000 claims abstract description 16
- 241000233866 Fungi Species 0.000 claims abstract description 15
- 238000006243 chemical reaction Methods 0.000 claims abstract description 9
- 230000005660 hydrophilic surface Effects 0.000 claims abstract description 7
- 230000005661 hydrophobic surface Effects 0.000 claims abstract description 7
- 229920000642 polymer Polymers 0.000 claims description 18
- 150000003512 tertiary amines Chemical class 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 230000001775 anti-pathogenic effect Effects 0.000 claims description 12
- 241001678559 COVID-19 virus Species 0.000 claims description 11
- 125000003178 carboxy group Chemical class [H]OC(*)=O 0.000 claims description 10
- 239000002245 particle Substances 0.000 claims description 9
- 239000000243 solution Substances 0.000 claims description 9
- 230000003253 viricidal effect Effects 0.000 claims description 8
- 239000012530 fluid Substances 0.000 claims description 7
- 230000007704 transition Effects 0.000 claims description 7
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 6
- 229920001513 poly[2-(diethylamino)ethyl methacrylate] polymer Polymers 0.000 claims description 6
- 239000007787 solid Substances 0.000 claims description 6
- 239000007864 aqueous solution Substances 0.000 claims description 5
- 150000003856 quaternary ammonium compounds Chemical class 0.000 claims description 5
- 238000006116 polymerization reaction Methods 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 3
- 239000004744 fabric Substances 0.000 claims description 3
- 239000011521 glass Substances 0.000 claims description 3
- 239000002184 metal Substances 0.000 claims description 3
- 229910052751 metal Inorganic materials 0.000 claims description 3
- 239000004033 plastic Substances 0.000 claims description 3
- 229920003023 plastic Polymers 0.000 claims description 3
- 229910052709 silver Chemical class 0.000 claims description 3
- 239000004332 silver Chemical class 0.000 claims description 3
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 3
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 3
- 239000004753 textile Substances 0.000 claims description 3
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical class [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims 2
- 230000005540 biological transmission Effects 0.000 claims 1
- 230000008569 process Effects 0.000 abstract description 2
- 230000002779 inactivation Effects 0.000 abstract 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 15
- 229910052802 copper Inorganic materials 0.000 description 15
- 239000010949 copper Substances 0.000 description 15
- 230000003075 superhydrophobic effect Effects 0.000 description 10
- 230000000840 anti-viral effect Effects 0.000 description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000000203 mixture Substances 0.000 description 5
- 230000003612 virological effect Effects 0.000 description 5
- 238000009736 wetting Methods 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 239000005871 repellent Substances 0.000 description 3
- 230000001846 repelling effect Effects 0.000 description 3
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 2
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 2
- 239000003929 acidic solution Substances 0.000 description 2
- 230000000843 anti-fungal effect Effects 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000001000 micrograph Methods 0.000 description 2
- 239000000123 paper Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000003753 real-time PCR Methods 0.000 description 2
- 230000002940 repellent Effects 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- OZAIFHULBGXAKX-UHFFFAOYSA-N 2-(2-cyanopropan-2-yldiazenyl)-2-methylpropanenitrile Chemical compound N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 description 1
- BXOOYTMDYUFBSZ-UHFFFAOYSA-N 2-dodecylsulfonylcarbothioylsulfonyl-2-methylpropanoic acid Chemical compound CCCCCCCCCCCCS(=O)(=O)C(=S)S(=O)(=O)C(C)(C)C(O)=O BXOOYTMDYUFBSZ-UHFFFAOYSA-N 0.000 description 1
- OZAIFHULBGXAKX-VAWYXSNFSA-N AIBN Substances N#CC(C)(C)\N=N\C(C)(C)C#N OZAIFHULBGXAKX-VAWYXSNFSA-N 0.000 description 1
- 101710134784 Agnoprotein Proteins 0.000 description 1
- SJIXRGNQPBQWMK-UHFFFAOYSA-N DEAEMA Natural products CCN(CC)CCOC(=O)C(C)=C SJIXRGNQPBQWMK-UHFFFAOYSA-N 0.000 description 1
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 239000012300 argon atmosphere Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229910002091 carbon monoxide Inorganic materials 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000005595 deprotonation Effects 0.000 description 1
- 238000010537 deprotonation reaction Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- WNAHIZMDSQCWRP-UHFFFAOYSA-N dodecane-1-thiol Chemical compound CCCCCCCCCCCCS WNAHIZMDSQCWRP-UHFFFAOYSA-N 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- -1 gauze Substances 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 229920001600 hydrophobic polymer Polymers 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- XKBGEWXEAPTVCK-UHFFFAOYSA-M methyltrioctylammonium chloride Chemical compound [Cl-].CCCCCCCC[N+](C)(CCCCCCCC)CCCCCCCC XKBGEWXEAPTVCK-UHFFFAOYSA-M 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000005588 protonation Effects 0.000 description 1
- 239000012265 solid product Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D133/00—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Coating compositions based on derivatives of such polymers
- C09D133/04—Homopolymers or copolymers of esters
- C09D133/14—Homopolymers or copolymers of esters of esters containing halogen, nitrogen, sulfur or oxygen atoms in addition to the carboxy oxygen
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/16—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
- A01N25/10—Macromolecular compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D5/00—Processes for applying liquids or other fluent materials to surfaces to obtain special surface effects, finishes or structures
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D5/00—Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced; Filling pastes
- C09D5/14—Paints containing biocides, e.g. fungicides, insecticides or pesticides
-
- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C18/00—Chemical coating by decomposition of either liquid compounds or solutions of the coating forming compounds, without leaving reaction products of surface material in the coating; Contact plating
- C23C18/02—Chemical coating by decomposition of either liquid compounds or solutions of the coating forming compounds, without leaving reaction products of surface material in the coating; Contact plating by thermal decomposition
- C23C18/08—Chemical coating by decomposition of either liquid compounds or solutions of the coating forming compounds, without leaving reaction products of surface material in the coating; Contact plating by thermal decomposition characterised by the deposition of metallic material
-
- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C18/00—Chemical coating by decomposition of either liquid compounds or solutions of the coating forming compounds, without leaving reaction products of surface material in the coating; Contact plating
- C23C18/14—Decomposition by irradiation, e.g. photolysis, particle radiation or by mixed irradiation sources
- C23C18/143—Radiation by light, e.g. photolysis or pyrolysis
-
- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C26/00—Coating not provided for in groups C23C2/00 - C23C24/00
-
- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C28/00—Coating for obtaining at least two superposed coatings either by methods not provided for in a single one of groups C23C2/00 - C23C26/00 or by combinations of methods provided for in subclasses C23C and C25C or C25D
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials Engineering (AREA)
- Organic Chemistry (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Mechanical Engineering (AREA)
- Metallurgy (AREA)
- Inorganic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
本文公开了具有可逆润湿性的涂层，该涂层具有疏水状态，其中所述涂层具有排斥细菌、真菌和病毒中至少一种的疏水表面；和亲水状态，其中所述涂层具有使细菌、真菌和病毒中的至少一种灭活的亲水表面，其中所述疏水状态可通过暴露于第一转换刺激而转换为所述亲水状态，并且所述亲水状态可通过暴露于第二转换刺激而转换为所述疏水状态。这种在超疏水性和超亲水性之间的可逆润湿性转换可以重复至少三次，这表明细菌、真菌或病毒的受控排斥或灭活过程至少可以转换三次。
Description
技术领域
本文公开了抗病原体涂层和防止细菌、真菌和病毒中的至少一种传播的方法，以及制备抗病原体涂层的方法。
背景技术
由于其自清洁和防水特性，开发液体排斥表面是减少病毒/细菌污染的有效方法。然而，由于粘附，仍然存在病毒残留物，这有害地将表面转化为污染物。
发明内容
为了提供对本发明的一些方面的基本理解，以下给出了本发明的简化概述。该概述不是对本发明的广泛概述。它既不旨在识别本发明的关键或重要要素，也不旨在描绘本发明的范围。相反，该概述的唯一目的是以简化形式呈现本发明的一些概念，作为下文呈现的更详细描述的序言。
鉴于上述问题，设计新型智能抗病原体表面以可控方式排斥和灭活附着在表面上的任何病毒(特别是SARS-CoV-2)或细菌具有重要意义。
本文公开了具有可逆润湿性的涂层，该涂层具有疏水状态，其中该涂层具有排斥含有细菌、真菌和病毒中至少一种的流体的疏水表面；和亲水状态，其中涂层具有锚定流体并使细菌、真菌和病毒中的至少一种灭活的亲水表面，其中疏水状态可通过暴露于第一转换刺激而转换为亲水状态，并且该亲水状态可通过暴露于第二转换刺激而转换为疏水状态。
本文还公开了防止细菌、真菌和病毒中的至少一种传播的方法，其涉及将具有可逆润湿性的涂层应用到固体表面，所述涂层包含疏水表面；以及将包含疏水表面的涂层暴露于转换刺激以产生包含亲水表面的涂层，其中具有亲水表面的涂层使细菌、真菌和病毒中的至少一种灭活。
本文还公开了制备具有可逆润湿性的涂层的方法，其涉及聚合烷基磺酰基硫代羰基磺酰基-羧酸；以及将Ag颗粒、叔胺基、羧基和季铵化合物中的至少一种添加到聚合产物中。
为了实现上述和相关目的，本发明包括在下文中充分描述并且在权利要求中特别指出的特征。以下描述和附图详细阐述了本发明的某些说明性方面和实施方式。然而，这些仅表示可以采用本发明原理的各种方式中的几种。当结合附图考虑时，本发明的其他目的、优点和新颖特征将从本发明的以下详细描述中变得显而易见。
附图说明
图1(A)和(B)分别是1微米水平和10微米水平的pH/CO2响应性智能铜板表面的扫描电子显微镜图像。(C)和(D)分别是1微米水平和10微米水平裸铜板表面的扫描电子显微镜图像。
图2A以图形方式描绘了pH/CO2响应性智能铜板在三个循环后对水滴的可逆润湿性。
图2B以图形方式描绘了pH/CO2响应性智能铜板对空气中水滴的粘附力。
图3(图3a和图3b)描绘了润湿性和接触角。
图4描绘了润湿性和接触角θ。
具体实施方式
本文描述了具有可调润湿性的pH/CO2响应性智能抗病原体涂层的开发，该涂层至少具有以下之一：排斥一种可载有病毒/细菌的液滴(或流体)并灭活残留的病毒/细菌。表面润湿性可通过pH/CO2刺激在超疏水性和超亲水性之间切换。智能抗病原体涂层在超疏水状态中可有效排斥病毒/细菌液滴。在暴露于转换刺激(例如溶解CO2的酸性水溶液/碳酸氢钠溶液/水)后，抗病原体涂层的表面成功地将润湿性从超疏水性变为超亲水性。在超亲水状态中，表面可以锚定载有病毒/细菌的液滴，并通过疏水和静电相互作用与病毒/细菌牢固结合。由于这种相互作用，病毒的分解随后使其自身表现为RNA泄漏到溶液中并丧失传染性。
本文所述的技术试图提高抗病原体涂层的超疏水性和超亲水性之间的可逆转换的响应率。在此，完成超疏水性和超亲水性之间的可逆循环通常需要至少20分钟但少于2小时。在另一个实施方案中，完成超疏水性和超亲水性之间的可逆循环通常需要至少30分钟但少于1小时。
开发了具有可逆润湿性的智能抗病原体涂层，以使表面排斥和灭活广谱的细菌、真菌和病毒，包括SARS-CoV-2。响应于转换刺激，例如pH/CO2刺激，表面润湿性可在超疏水性和超亲水性之间转换。载有病毒/细菌的液滴(或液体)在超疏水状态中被表面脱落，而在超亲水状态下锚定在表面上。浸渍有抗病毒和抗微生物剂(例如季铵化合物、质子化叔胺基、羧基和/或银)的超亲水涂层能够杀死与其接触的病毒或细菌。智能涂层可应用于固体表面，例如金属、塑料、玻璃、聚合物、纸张、纺织品、织物、纱布和其他纤维。
涂层的可转换润湿性行为源于，例如CO2响应性聚合物分子中的叔胺基团的可逆质子化/去质子化。疏水性聚合物链在中性水溶液中保持脱水和塌缩的形式。在暴露于dCO2(或NaHCO3)溶液时，CO2响应性聚合物中的叔胺基团被CO2与水反应产生的碳酸质子化为带正电荷的叔胺，其呈现出亲水性构型。随着聚合物链化学结构的可逆变化，表面润湿性可以反复转换。
智能抗病原体涂层的要素包括具有可逆润湿性的液体排斥表面，其对广泛范围的病毒和细菌，特别是SARS-CoV-2具有更强的功效。例如，智能抗病原体涂层可以在超疏水状态中以99.98％的比率有效排斥载有SARS-CoV-2病毒的液滴。在另一个实施方案中，智能抗病原体涂层可以在超疏水状态中以99.99％的比率有效排斥载有SARS-CoV-2病毒的液滴。智能抗病原体涂层的要素还包括一种pH/CO2响应性聚合物羧基封端的聚(甲基丙烯酸-2-(二乙氨基)乙酯)，其是杀病毒的。该聚合物的杀病毒效率大于80％。在另一个实施方案中，该聚合物的杀病毒效率大于85％。
如图3所示，接触角值被用作衡量液体对固体的润湿性的标准。一般来说，当接触角大于90度时(见图3a)，其被定义为“非润湿系统”或“疏水”，当接触角小于90度时(见图3b)，其被定义为“润湿系统”或“亲水”。在另一个实施方案中，疏水涂层具有100度或更大的接触角值并且亲水涂层具有80度或更小的接触角值。在又一个实施方案中，疏水涂层具有120度或更大的接触角值并且亲水涂层具有60度或更小的接触角值。图4提供了另一个观察接触角(θ)的视图。
本文描述了提供可调润湿性和抗病原体特性的pH/CO2响应性智能抗病原体涂层的制造和使用。涂层包括pH/CO2响应性聚合物、低表面能材料和一金属Ag层。Ag层提供了表面的分级粗糙度。这种具有低表面能并包含具有分级纳米/微米结构的表面的涂层代表了超疏水性的基础。通过对pH/CO2响应性聚合物的修饰，改变外部刺激来控制表面的润湿性行为。例如，涂层在pH 7或更高的空气中是超疏水的，而在pH 5.5或更低的水性介质中是超亲水的。此外，本文所述的涂层表现出可调的抗病原体特性，该特性由表面的润湿性调节。载有病毒/细菌的水性液滴(流体)在超疏水状态中被表面脱落，而在超亲水状态中锚定在表面上。
本文还描述了以下发现：包含叔胺和羧基的pH/CO2响应性聚合物羧基封端的聚(甲基丙烯酸-2-(二乙氨基)乙酯)是杀病毒/杀菌的。在暴露于弱酸性溶液(例如，pH 5.5或更低)时，pH/CO2响应性聚合物分子中的叔胺基团被质子化为带正电荷的叔胺。当载有病毒/细菌的水性液滴(流体)粘附在超亲水涂层上时，病毒/细菌(尤其是SARS-CoV-2)可以被带正电荷的叔胺和带负电荷的羧基灭活。
这种pH/CO2响应性智能抗病原体涂层采用两步法构建，其能够被应用于各种尺寸、形状和几何结构的各种金属、塑料、玻璃、聚合物、纸张、纺织品、织物、纱布和其他纤维基材。这种涂层的应用可以是抗微生物、抗润湿、抗腐蚀、自清洁或除冰应用中的一种或多种形式。
作为一般示例，智能抗病原体涂层包含足量的pH/CO2响应性聚合物和抗病毒颗粒(和/或根据所需情况抗细菌、抗真菌，但为简洁仅描述抗病毒)以具有疏水性-亲水性转换和杀病毒/病毒复制抑制(和/或相应的抗细菌和/或抗真菌特性)两者的特性。在一个实施方案中，智能抗病原体涂层包含按重量计2％至20％的pH/CO2响应性聚合物，按重量计5％至40％的抗病毒颗粒，余量是其他涂层材料和/或添加剂，其促进涂层形成，但不抑制pH/CO2响应性聚合物和抗病毒颗粒的性能。在另一个实施方案中，智能抗病原体涂层包含按重量计3％至15％的pH/CO2响应性聚合物，按重量计10％至30％的抗病毒颗粒。在又一个实施方案中，智能抗病原体涂层包含按重量计4％至12％的pH/CO2响应性聚合物，按重量计15％至25％的抗病毒颗粒。
pH/CO2响应性智能涂层的制备
pH/CO2响应性共聚物羧基封端的聚(甲基丙烯酸-2-(二乙氨基)乙酯)(PDEM-CT)是通过可逆加成断裂转移(RAFT)聚合合成的。首先，合成了2-十二烷基磺酰基硫代羰基磺酰基-2-甲基丙酸(DMP)。DMP如下制备。通常，8.076g的1-十二硫醇、19.24g的丙酮和0.6g的三辛酰基甲基氯化铵在10℃于氩气气氛中搅拌。然后将1.6mL的NaOH水溶液(50wt％)、3.04g的CS2和4.04g的丙酮依次滴加到混合物中。搅拌15分钟后，将7.13g的CHCl3倒入上述混合物中。随后，向所得混合物中滴加1.6mL的NaOH水溶液(50wt％)。在室温搅拌8小时后，将60mL水和10mL浓HCl依次加入混合物中。最后通过减压蒸馏除去丙酮。得到的固体用2-丙醇洗涤并在室温干燥。
然后，将DEAEMA(364.64mg)、DMP(16.4mg)和AIBN(30mg)溶解在Schlenk烧瓶中的6mL的1,4-二噁烷中，并通过三个冷冻-真空-解冻循环小心地将上述混合物脱气。反应在真空下在70℃持续18小时。聚合后，产物用5mL的1,4-二噁烷稀释，并通过在蒸馏水(pH 4.5)中渗析72小时进行纯化。最后，收集固体产物并通过冻干法干燥。在示例性实施方案中，将一块铜板浸入1.0mg ml-1AgNO3水溶液中。该溶液用紫外线(UV，254nm，3W)灯照射20分钟以在铜板上沉积一层银纳米颗粒。用蒸馏水洗涤并在空气中干燥后，将得到的铜板在含有50mg mL-1的pH/CO2响应性共聚物和1μL mL-1的1H、1H、2H、2H-全氟癸硫醇的乙醇溶液中温育8小时。之后，用乙醇洗涤样品以去除吸附化学物质，然后在50℃真空干燥5小时。
所得铜板表现出超疏水性，水接触大于150°。使用定量RT-PCR(实时聚合酶链式反应)基于病毒基因组拷贝数确定超疏水铜板表面上的病毒残留物。研究发现，超疏水铜板可以99.98％的比率有效排斥载有SARS-CoV-2病毒的液滴。当所制备的铜板暴露于弱酸性溶液(pH 5.5)时，铜板表面的润湿性从超疏水性变为超亲水性，水接触为0°。将超亲水铜板放入24孔板中，并将杜氏改良Eagle培养基(Dulbecco’s Modified Eagle Medium，DMEM)中的SARS-CoV-2溶液的液滴沉积在铜板的中心。温育24小时后，去除所得铜板，将板中的SARS-CoV-2等分用于6孔板中的VeroE6细胞的噬菌斑测定，以确定病毒感染性。在感染后72小时对6孔板中的VeroE6细胞的噬菌斑进行染色和计数。结果表明，智能抗病原体涂层的杀病毒效率为85.3％。
除非在实施例和说明书和权利要求的其他地方另有说明，所有份数和百分比均以重量计，所有温度均以摄氏度为单位，并且压力处于或接近大气压。
对于给定特征的任何数字或数值范围，来自一个范围的数字或参数可以与来自用于相同特征的不同范围的另一数字或参数组合以产生数值范围。
除了在操作实施例中或另有说明的情况下，在说明书和权利要求书中使用的涉及成分的量、反应条件等的所有数字、值和/或表达应理解为在所有情况下通过术语“约”修饰。
虽然结合某些实施方案解释了本发明，但应理解，在阅读本说明书后，其各种修改将对本领域技术人员变得显而易见。因此，应该理解，本文公开的发明旨在覆盖落入所附权利要求范围内的这些修改。
Claims (22)
1.具有可逆润湿性的涂层，其包含：
疏水状态，其中所述涂层具有排斥含有细菌、真菌和病毒中至少一种的流体的疏水表面；和
亲水状态，其中所述涂层具有锚定流体并使细菌、真菌和病毒中的至少一种灭活的亲水表面，
其中所述疏水状态可通过暴露于第一转换刺激而转换为所述亲水状态，并且所述亲水状态可通过暴露于第二转换刺激而转换为所述疏水状态。
2.根据权利要求1所述的涂层，其中所述涂层包含质子化叔胺、羧基、季铵化合物和银颗粒中的至少一种。
3.根据权利要求1所述的涂层，其中所述涂层包含具有叔胺和羧基的羧基封端的聚(甲基丙烯酸-2-(二乙氨基)乙酯)。
4.根据权利要求1所述的涂层，其中所述第一转换刺激是溶解CO2的酸性水溶液/碳酸氢钠溶液/水。
5.根据权利要求1所述的涂层，其中所述细菌、真菌和病毒中的至少一种是SARS-CoV-2病毒。
6.根据权利要求1所述的涂层，其中所述涂层的所述亲水状态具有80％或更高的杀病毒效率。
7.根据权利要求1所述的涂层，其中所述涂层的所述亲水状态具有85％或更高的杀病毒效率。
8.根据权利要求1所述的涂层，其中所述涂层的所述疏水状态可以99.98％的比率有效排斥载有病毒的液滴。
9.根据权利要求1所述的涂层，其中所述涂层的所述疏水状态具有水接触大于150°的疏水性。
10.根据权利要求1所述的涂层，其中所述涂层的所述亲水状态具有水接触为0°的亲水性。
11.根据权利要求1所述的涂层，其中所述第二转换刺激为用N2吹扫然后在空气中用N2干燥的水。
12.根据权利要求1所述的涂层，其中所述疏水状态可转换为所述亲水状态且所述亲水状态可转换为所述疏水状态至少三个循环。
13.根据权利要求1-12中任一项所述的涂层，其中所述涂层为抗病原体涂层。
14.防止细菌、真菌和病毒中的至少一种传播的方法，其包括：
将具有可逆润湿性的涂层应用到固体表面，所述涂层包含疏水表面；以及
将包含疏水表面的涂层暴露于转换刺激以产生包含亲水表面的涂层，其中具有亲水表面的涂层使细菌、真菌和病毒中的至少一种灭活。
15.根据权利要求14所述的方法，其中所述固体表面是金属、塑料、玻璃、聚合物、纸张、纺织品、织物和纱布中的一种或多种。
16.根据权利要求14所述的方法，其中所述涂层包含质子化叔胺、羧基、季铵化合物和银颗粒中的至少一种。
17.根据权利要求14所述的方法，其中所述涂层包含具有叔胺和羧基的羧基封端的聚(甲基丙烯酸-2-(二乙氨基)乙酯)。
18.根据权利要求14所述的方法，其中所述转换刺激为溶解CO2的酸性水溶液/碳酸氢钠溶液/水。
19.根据权利要求14所述的方法，其中所述细菌、真菌和病毒中的至少一种是SARS-CoV-2病毒。
20.根据权利要求14-19中任一项所述的方法，其中所述涂层为抗病原体涂层。
21.制备具有可逆润湿性的涂层的方法，其包括：
聚合烷基磺酰基硫代羰基磺酰基-羧酸；以及
将Ag颗粒、叔胺基、羧基和季铵化合物中的至少一种添加到聚合产物中。
22.根据权利要求21所述的方法，其中所述涂层为抗病原体涂层。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163185390P | 2021-05-07 | 2021-05-07 | |
| US63/185,390 | 2021-05-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115304977A true CN115304977A (zh) | 2022-11-08 |
Family
ID=83855303
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210491960.7A Pending CN115304977A (zh) | 2021-05-07 | 2022-05-07 | 控制、排斥和/或灭活病毒和细菌的pH/CO2响应性智能抗病原体涂层 |
Country Status (2)
| Country | Link |
|---|---|
| US (1) | US20220354122A1 (zh) |
| CN (1) | CN115304977A (zh) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120015146A1 (en) * | 2010-07-13 | 2012-01-19 | The University Of Houston System | Types of electrodeposited polymer coatings with reversible wettability and electro-optical properties |
| US20160244548A1 (en) * | 2013-09-18 | 2016-08-25 | Queen's University At Kingston | Switchable materials, methods and uses thereof |
| CN108355379A (zh) * | 2018-03-23 | 2018-08-03 | 哈尔滨工业大学 | 一种co2响应智能亲疏水转换铜网的制备方法 |
| CN110664751A (zh) * | 2019-10-25 | 2020-01-10 | 西北师范大学 | 一种pH响应性聚合物纳米胶束及其制备和应用 |
| CN111991563A (zh) * | 2020-09-03 | 2020-11-27 | 西北师范大学 | pH响应型纳米药物递送系统及其制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014097309A1 (en) * | 2012-12-17 | 2014-06-26 | Asian Paints Ltd. | Stimuli responsive self cleaning coating |
-
2022
- 2022-05-06 US US17/738,037 patent/US20220354122A1/en not_active Abandoned
- 2022-05-07 CN CN202210491960.7A patent/CN115304977A/zh active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120015146A1 (en) * | 2010-07-13 | 2012-01-19 | The University Of Houston System | Types of electrodeposited polymer coatings with reversible wettability and electro-optical properties |
| US20160244548A1 (en) * | 2013-09-18 | 2016-08-25 | Queen's University At Kingston | Switchable materials, methods and uses thereof |
| CN108355379A (zh) * | 2018-03-23 | 2018-08-03 | 哈尔滨工业大学 | 一种co2响应智能亲疏水转换铜网的制备方法 |
| CN110664751A (zh) * | 2019-10-25 | 2020-01-10 | 西北师范大学 | 一种pH响应性聚合物纳米胶束及其制备和应用 |
| CN111991563A (zh) * | 2020-09-03 | 2020-11-27 | 西北师范大学 | pH响应型纳米药物递送系统及其制备方法 |
Non-Patent Citations (2)
| Title |
|---|
| 杨海涛: "光聚合制备不同润湿性表面功能化材料及其性能研究" * |
| 熊新红: "超亲水/超疏水可逆转变的聚离子液改性材料表面" * |
Also Published As
| Publication number | Publication date |
|---|---|
| US20220354122A1 (en) | 2022-11-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Cheng et al. | Antifouling and antibacterial polymer-coated surfaces based on the combined effect of zwitterions and the natural borneol | |
| Li et al. | Permanent antimicrobial cotton fabrics obtained by surface treatment with modified guanidine | |
| KR102195307B1 (ko) | 표면에 대한 콜로이드성 항균 및 항-생물부착 코팅 | |
| JP6573606B2 (ja) | グアニジニル含有ポリマーを有する拭き取り用品 | |
| Kong et al. | Hydrophobic N-halamine based POSS block copolymer porous films with antibacterial and resistance of bacterial adsorption performances | |
| KR102065159B1 (ko) | 불소중합체 및 불소중합체를 포함한 막(ii) | |
| WO2007147094A2 (en) | Novel polymer-nano/microparticle composites | |
| CN111333862B (zh) | 一种抗病毒乳液组合物及涂料及其制备方法 | |
| TWI648296B (zh) | 氟聚合物及包含氟聚合物（ｉ）的膜 | |
| CN110885398A (zh) | 一种抗菌阳离子含氟聚合物微球乳液的制备方法 | |
| WO2007061954A2 (en) | Biocidal surfaces, articles with biocidal surface agents and methods of synthesizing and evaluating biocidal surface agents | |
| Abu-Saied et al. | Preparation and characterization of iminated polyacrylonitrile for the removal of methylene blue from aqueous solutions | |
| EP3518984A1 (en) | Nanocluster capped mesoporous nanoparticles, methods of making and use | |
| CN110885592A (zh) | 一种超疏水抗菌阳离子含氟聚合物纳米涂层 | |
| Guo-Dong et al. | Solvent-resistant antibacterial microfibers of self-quaternized block copolymers from atom transfer radical polymerization and electrospinning | |
| CN108057348A (zh) | 一种亲水性杀菌抗污染反渗透膜及其制法 | |
| Lou et al. | Self-disinfecting PDMS surfaces with high quaternary ammonium functionality by direct surface photoinitiated polymerization of vinylbenzyl dimethylbutylammonium chloride | |
| CN115304977A (zh) | 控制、排斥和/或灭活病毒和细菌的pH/CO2响应性智能抗病原体涂层 | |
| Chiu et al. | Intelligent sterilizable self-cleaning membranes triggered by sustainable counterion-induced bacteria killing/releasing procedure | |
| CN109046045A (zh) | 一种水亲润型抗污耐氯芳香聚酰胺复合膜的制备方法 | |
| US9587141B2 (en) | Hydrogen cyanide-based polymer surface coatings and hydrogels | |
| Meng et al. | Polymeric nanoparticles-based multi-functional coatings on NiTi alloy with nickel ion release control, cytocompatibility, and antibacterial performance | |
| Wu et al. | Manipulation of surface properties and long-term antibacterial performance of composite films via alkyl side chain engineering | |
| CN108178962B (zh) | 一种两性离子防污涂料树脂及其制备方法 | |
| US20100034858A1 (en) | Biocidal coatings |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20221108 |
|
| RJ01 | Rejection of invention patent application after publication |