CN115300601A - 一种治疗消化系统疾病的发酵组合物 - Google Patents

一种治疗消化系统疾病的发酵组合物 Download PDF

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CN115300601A
CN115300601A CN202211125496.6A CN202211125496A CN115300601A CN 115300601 A CN115300601 A CN 115300601A CN 202211125496 A CN202211125496 A CN 202211125496A CN 115300601 A CN115300601 A CN 115300601A
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digestive system
system diseases
fermented composition
fermentation
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金春燕
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Golden Orange Salt Biotechnology Shanghai Co ltd
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Abstract

本发明涉及益生菌提取技术领域，且公开了一种治疗消化系统疾病的发酵组合物，所述该发酵组合物的制备方法如下：将包括具有适当重量比的中药复方经水提取，浓缩至适当浓度，加入适量碳源、氮源和无机盐，调整pH7.0左右并于灭菌后，得到继后用于益生菌发酵的底物，温度降至39℃左右时，接种预培养的一种或者两种双歧杆菌的菌液，常规培养约2～6小时后，或同时接种预培养的一种或者两种双歧杆菌的菌液和预培养的一种或者两种乳杆菌的菌液，常规发酵22～48小时，当pH降至4.2以下时结束发酵。该治疗消化系统疾病的发酵组合物，通过利用人体的多种肠道益生菌与本发明使用的健脾和胃中药复方提取物一起发酵，以实现肠道益生菌与中药的协同作用。

Description

一种治疗消化系统疾病的发酵组合物
技术领域
本发明涉及益生菌提取技术领域，具体为一种治疗消化系统疾病的发酵组合物。
背景技术
中草药治病的物质基础是其所含有的化学物质，这些化学物质以传统的汤剂即水提取物的形式经口进入人体之后，可表现有不同的运转途径：(1)原型化合物被机体吸收并进入循环发挥其药理作用；(2)原型化合物被机体吸收，经肝肠循环或在组织或血液内经过一系列代谢加工后发挥其药理作用；(3)化合物不被吸收，只能随粪便排出体外；(4)药物或其原型化合物在肠道正常菌群的作用下，发生某些由肠道细菌代谢酶导致的化学改变，改善了其吸收率、运转速度及生物学活性，从而在降低毒副作用的同时更有利于其药理学功能的发挥。因此，从实验室药代动力学研究和临床应用观察两方面入手，深入研究人肠道益生菌对天然药物化合物的加工与代谢转化，对于阐明传统中药的作用机理具有十分重要的意义。
利用中药发酵技术开发创新药物已成为当今世界药物研发的新趋势、国际医药学术界的研究热点。中药发酵技术是在继承中药炮制学发酵法的基础上，吸取微生态学研究成果，结合现代微生物工程而形成的高科技中药制药新技术。中药发酵是现代中药研究的热点，其优点可概括为：①保护中药活性成分免遭破坏，使药物的有效组分、活性物质最大限度地得以提取、利用；②提高中药药性，降低药物的毒副作用；③所优选的有益菌种本身能补充或增强原有药物的功能；④产生新的生物学活性物质；⑤为中药活性成分结构修饰提供新途径；⑥节省药材资源，保护环境；⑦是实现中药现代化、具有高科技水平的新技术，生产工艺可控，所得产物精确，制剂方便，便于与国际接轨，因此本发明提供了一种治疗消化系统疾病的发酵组合物。
发明内容
(一)解决的技术问题
针对现有技术的不足，本发明提供了一种治疗消化系统疾病的发酵组合物，解决了上述背景技术中提出的问题。
(二)技术方案
为实现以上目的，本发明提供如下技术方案：一种治疗消化系统疾病的发酵组合物，所述该发酵组合物的制备方法如下：将包括具有适当重量比的中药复方经水提取，浓缩至适当浓度，加入适量碳源、氮源和无机盐，调整pH7.0左右并于灭菌后，得到继后用于益生菌发酵的底物，温度降至39℃左右时，接种预培养的一种或者两种双歧杆菌的菌液，常规培养约2～6小时后，再次接种预培养的一种或者两种乳杆菌的菌液，然后继续培养约20～42小时，或同时接种预培养的一种或者两种双歧杆菌的菌液和预培养的一种或者两种乳杆菌的菌液，常规发酵22～48小时，当pH降至4.2以下时结束发酵。
优选的，所述其中所说的健脾和健胃中药复方提取物是麦芽、山楂、茯苓、陈皮、大枣、甘草、生姜和萝卜的提取物。
优选的，所述其中所说的益生菌选自两歧双歧杆菌、短双歧杆菌、青春双歧杆菌和婴儿双歧杆菌的双歧杆菌和选自嗜酸乳杆菌、德氏乳杆菌、植物乳杆菌、干酪乳杆菌和鼠李糖乳杆菌的乳杆菌。
优选的，所述健脾和胃中药复方提取物经肠道益生菌发酵产物和一种或多种医药上可接受的载体或赋形剂组成的发酵组合物制剂。
优选的，所述发酵组合物在制备用于预防和治疗消化系统疾病的药品中的应用。
优选的，所述发酵组合物在制备用于预防和治疗消化系统疾病的食品或保健食品中的应用。
(三)有益效果
与现有技术相比，本发明提供了一种治疗消化系统疾病的发酵组合物，具备以下有益效果：
该治疗消化系统疾病的发酵组合物，通过利用人体的多种肠道益生菌与本发明使用的健脾和胃中药复方提取物一起发酵，以实现肠道益生菌与中药的协同作用。结果令人惊奇地发现，健脾和胃中药复方提取物经与肠道益生菌共同发酵处理后，显著的提高和改善了其预防和治疗消化系统疾病的功能。
具体实施方式
下面将结合本发明实施例，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
本发明提供一种技术方案：所述该发酵组合物的制备方法如下：将包括具有适当重量比的中药复方经水提取，浓缩至适当浓度，加入适量碳源、氮源和无机盐，调整pH7.0左右并于灭菌后，得到继后用于益生菌发酵的底物，温度降至39℃左右时，接种预培养的一种或者两种双歧杆菌的菌液，常规培养约2～6小时后，再次接种预培养的一种或者两种乳杆菌的菌液，然后继续培养约20～42小时，或同时接种预培养的一种或者两种双歧杆菌的菌液和预培养的一种或者两种乳杆菌的菌液，常规发酵22～48小时，当pH降至4.2以下时结束发酵，所述其中所说的健脾和健胃中药复方提取物是麦芽、山楂、茯苓、陈皮、大枣、甘草、生姜和萝卜的提取物，所述其中所说的益生菌选自两歧双歧杆菌、短双歧杆菌、青春双歧杆菌和婴儿双歧杆菌的双歧杆菌和选自嗜酸乳杆菌、德氏乳杆菌、植物乳杆菌、干酪乳杆菌和鼠李糖乳杆菌的乳杆菌，所述健脾和胃中药复方提取物经肠道益生菌发酵产物和一种或多种医药上可接受的载体或赋形剂组成的发酵组合物制剂，所述发酵组合物在制备用于预防和治疗消化系统疾病的药品中的应用，所述发酵组合物在制备用于预防和治疗消化系统疾病的食品或保健食品中的应用。
综上所述，该治疗消化系统疾病的发酵组合物，通过利用人体的多种肠道益生菌与本发明使用的健脾和胃中药复方提取物一起发酵，以实现肠道益生菌与中药的协同作用。结果令人惊奇地发现，健脾和胃中药复方提取物经与肠道益生菌共同发酵处理后，显著的提高和改善了其预防和治疗消化系统疾病的功能。
需要说明的是，在本文中，诸如第一和第二等之类的关系术语仅仅用来将一个实体或者操作与另一个实体或操作区分开来，而不一定要求或者暗示这些实体或操作之间存在任何这种实际的关系或者顺序。而且，术语“包括”、“包含”或者其任何其他变体意在涵盖非排他性的包含，从而使得包括一系列要素的过程、方法、物品或者设备不仅包括那些要素，而且还包括没有明确列出的其他要素，或者是还包括为这种过程、方法、物品或者设备所固有的要素。在没有更多限制的情况下，由语句“包括一个……”限定的要素，并不排除在包括所述要素的过程、方法、物品或者设备中还存在另外的相同要素。
尽管已经示出和描述了本发明的实施例，对于本领域的普通技术人员而言，可以理解在不脱离本发明的原理和精神的情况下可以对这些实施例进行多种变化、修改、替换和变型，本发明的范围由所附权利要求及其等同物限定。

Claims (6)

1.一种治疗消化系统疾病的发酵组合物，其特征在于：所述该发酵组合物的制备方法如下：将包括具有适当重量比的中药复方经水提取，浓缩至适当浓度，加入适量碳源、氮源和无机盐，调整pH7.0左右并于灭菌后，得到继后用于益生菌发酵的底物，温度降至39℃左右时，接种预培养的一种或者两种双歧杆菌的菌液，常规培养约2～6小时后，再次接种预培养的一种或者两种乳杆菌的菌液，然后继续培养约20～42小时，或同时接种预培养的一种或者两种双歧杆菌的菌液和预培养的一种或者两种乳杆菌的菌液，常规发酵22～48小时，当pH降至4.2以下时结束发酵。
2.根据权利要求1所述的一种治疗消化系统疾病的发酵组合物，其特征在于：所述其中所说的健脾和健胃中药复方提取物是麦芽、山楂、茯苓、陈皮、大枣、甘草、生姜和萝卜的提取物。
3.根据权利要求1所述的一种治疗消化系统疾病的发酵组合物，其特征在于：所述其中所说的益生菌选自两歧双歧杆菌、短双歧杆菌、青春双歧杆菌和婴儿双歧杆菌的双歧杆菌和选自嗜酸乳杆菌、德氏乳杆菌、植物乳杆菌、干酪乳杆菌和鼠李糖乳杆菌的乳杆菌。
4.根据权利要求1所述的一种治疗消化系统疾病的发酵组合物，其特征在于：所述健脾和胃中药复方提取物经肠道益生菌发酵产物和一种或多种医药上可接受的载体或赋形剂组成的发酵组合物制剂。
5.根据权利要求1所述的一种治疗消化系统疾病的发酵组合物，其特征在于：所述发酵组合物在制备用于预防和治疗消化系统疾病的药品中的应用。
6.根据权利要求1所述的一种治疗消化系统疾病的发酵组合物，其特征在于：所述发酵组合物在制备用于预防和治疗消化系统疾病的食品或保健食品中的应用。
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