CN115300425B - Toothpaste for cleaning oral cavity - Google Patents
Toothpaste for cleaning oral cavity Download PDFInfo
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- CN115300425B CN115300425B CN202210945232.9A CN202210945232A CN115300425B CN 115300425 B CN115300425 B CN 115300425B CN 202210945232 A CN202210945232 A CN 202210945232A CN 115300425 B CN115300425 B CN 115300425B
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- 239000000606 toothpaste Substances 0.000 title claims abstract description 43
- 229940034610 toothpaste Drugs 0.000 title claims abstract description 41
- 238000004140 cleaning Methods 0.000 title claims abstract description 24
- 210000000214 mouth Anatomy 0.000 title claims abstract description 16
- 239000000843 powder Substances 0.000 claims abstract description 145
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 81
- 239000000284 extract Substances 0.000 claims abstract description 47
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 claims abstract description 45
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 45
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 claims abstract description 45
- 229940010454 licorice Drugs 0.000 claims abstract description 45
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 40
- 235000008422 Schisandra chinensis Nutrition 0.000 claims abstract description 31
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 claims abstract description 30
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims abstract description 30
- 229920001661 Chitosan Polymers 0.000 claims abstract description 30
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims abstract description 30
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims abstract description 30
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 30
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims abstract description 30
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims abstract description 30
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims abstract description 30
- 229940073507 cocamidopropyl betaine Drugs 0.000 claims abstract description 30
- 239000008367 deionised water Substances 0.000 claims abstract description 30
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 30
- LRCFXGAMWKDGLA-UHFFFAOYSA-N dioxosilane;hydrate Chemical compound O.O=[Si]=O LRCFXGAMWKDGLA-UHFFFAOYSA-N 0.000 claims abstract description 30
- 229960004029 silicic acid Drugs 0.000 claims abstract description 30
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 claims abstract description 30
- 229960004711 sodium monofluorophosphate Drugs 0.000 claims abstract description 30
- 239000000600 sorbitol Substances 0.000 claims abstract description 30
- 229940013618 stevioside Drugs 0.000 claims abstract description 30
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims abstract description 30
- 235000019202 steviosides Nutrition 0.000 claims abstract description 30
- 240000006079 Schisandra chinensis Species 0.000 claims abstract description 29
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 22
- 239000011575 calcium Substances 0.000 claims abstract description 22
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 22
- 108700004121 sarkosyl Proteins 0.000 claims abstract description 21
- 229940045885 sodium lauroyl sarcosinate Drugs 0.000 claims abstract description 21
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims abstract description 20
- 238000000034 method Methods 0.000 claims abstract description 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 106
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 86
- YQUVCSBJEUQKSH-UHFFFAOYSA-N 3,4-dihydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C(O)=C1 YQUVCSBJEUQKSH-UHFFFAOYSA-N 0.000 claims description 80
- 238000003756 stirring Methods 0.000 claims description 69
- 229960000583 acetic acid Drugs 0.000 claims description 53
- 239000012362 glacial acetic acid Substances 0.000 claims description 53
- 239000007788 liquid Substances 0.000 claims description 47
- 241000157835 Gardenia Species 0.000 claims description 46
- 241000202807 Glycyrrhiza Species 0.000 claims description 44
- 239000007864 aqueous solution Substances 0.000 claims description 44
- 230000001954 sterilising effect Effects 0.000 claims description 40
- 239000007790 solid phase Substances 0.000 claims description 36
- 239000000203 mixture Substances 0.000 claims description 35
- 239000000243 solution Substances 0.000 claims description 32
- 238000002360 preparation method Methods 0.000 claims description 28
- 238000001035 drying Methods 0.000 claims description 27
- 239000007791 liquid phase Substances 0.000 claims description 27
- 238000007872 degassing Methods 0.000 claims description 20
- 238000000926 separation method Methods 0.000 claims description 20
- 238000004659 sterilization and disinfection Methods 0.000 claims description 20
- 238000000227 grinding Methods 0.000 claims description 18
- 238000002156 mixing Methods 0.000 claims description 18
- 238000002390 rotary evaporation Methods 0.000 claims description 18
- 238000007873 sieving Methods 0.000 claims description 18
- 239000007787 solid Substances 0.000 claims description 16
- 239000000463 material Substances 0.000 claims description 10
- 238000005303 weighing Methods 0.000 claims description 10
- 101000623895 Bos taurus Mucin-15 Proteins 0.000 claims description 9
- 238000001816 cooling Methods 0.000 claims description 9
- 238000005520 cutting process Methods 0.000 claims description 9
- 238000004108 freeze drying Methods 0.000 claims description 9
- 238000010298 pulverizing process Methods 0.000 claims description 9
- 238000002791 soaking Methods 0.000 claims description 9
- 239000000551 dentifrice Substances 0.000 claims description 2
- 229960005150 glycerol Drugs 0.000 abstract description 10
- 229960002920 sorbitol Drugs 0.000 abstract description 10
- 230000002087 whitening effect Effects 0.000 abstract description 9
- 241000191967 Staphylococcus aureus Species 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 5
- 230000005764 inhibitory process Effects 0.000 abstract description 4
- 244000111489 Gardenia augusta Species 0.000 abstract 1
- 240000004670 Glycyrrhiza echinata Species 0.000 abstract 1
- 239000000686 essence Substances 0.000 description 36
- 235000011187 glycerol Nutrition 0.000 description 27
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 8
- 230000000052 comparative effect Effects 0.000 description 8
- 235000019700 dicalcium phosphate Nutrition 0.000 description 8
- 230000000844 anti-bacterial effect Effects 0.000 description 6
- 239000001963 growth medium Substances 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 208000002064 Dental Plaque Diseases 0.000 description 2
- 241000736075 Schisandra Species 0.000 description 2
- 208000002925 dental caries Diseases 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 208000004509 Tooth Discoloration Diseases 0.000 description 1
- 206010044032 Tooth discolouration Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000005282 brightening Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 210000004268 dentin Anatomy 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000004088 foaming agent Substances 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000013588 oral product Substances 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 230000036367 tooth discoloration Effects 0.000 description 1
Abstract
The application discloses an oral cavity cleaning toothpaste, which comprises the components of calcium hydrophosphate, hydrated silica, sorbitol, glycerol, sodium monofluorophosphate, sodium lauroyl sarcosinate, cocamidopropyl betaine, carboxymethyl chitosan, cellulose gum, licorice leaf powder, gardenia powder, stevioside, schisandra chinensis extract and deionized water. The oral cavity cleaning toothpaste prepared by the method has good whitening effect on teeth and has obvious inhibition effect on staphylococcus aureus.
Description
Technical Field
The invention belongs to the technical field of oral cleaning products, and particularly relates to an oral cleaning toothpaste.
Background
In the current society, people have increasingly improved knowledge of oral health care, and various Chinese herbal medicine oral products with obvious efficacy and few side effects are touted by people. Toothpaste is a common oral care product for people, and has the basic functions of refreshing breath, keeping oral health and protecting teeth. In addition, the functional toothpaste with specific effects has the functions of inhibiting dental plaque growth, reducing dental plaque growth, preventing dental caries, slowing down further deterioration of the generated dental caries, resisting dentin hypersensitiveness, improving tooth discoloration, brightening and whitening and protecting dental enamel and other special functions. The toothpaste not only protects the oral health of people, but also is an important component of national economy.
Toothpaste is a paste-like substance, and contains friction agent, humectant, thickener, foaming agent, aromatic, water and other additives (including functional components for improving oral health). Toothpaste is a commonly used oral cleaning product in daily life. It is a dentifrice, usually in the form of a gel. It is commonly applied to toothbrushes to clean teeth and maintain the teeth aesthetically pleasing. With the continuous improvement and development of science and technology, the continuous improvement and perfection of technology and equipment, various toothpastes are continuously developed, and the quality and grade of products are also continuously improved.
Disclosure of Invention
The invention provides an oral cavity cleaning toothpaste, which is characterized by comprising the following components of calcium hydrophosphate, hydrated silica, sorbitol, glycerin, sodium monofluorophosphate, sodium lauroyl sarcosine, cocamidopropyl betaine, carboxymethyl chitosan, cellulose gum, licorice leaf powder, gardenia powder, stevioside, schisandra chinensis extract, essence and deionized water.
Further, the licorice leaf powder is sieved powder obtained by sieving licorice leaves with a 50-mesh sieve after sun drying and grinding the licorice leaves into powder; the gardenia powder is obtained by sun-drying gardenia petals, grinding into powder, and sieving with a 50-mesh sieve.
Further, the preparation method of the schisandra chinensis extract comprises the following steps:
(1) Separating fructus Schisandrae pulp from kernel, cutting pulp into pieces, pulverizing kernel, and mixing the pieces and kernel powder to obtain a mixture;
(2) Preparing an aqueous solution of glacial acetic acid, adding the mixture into the aqueous solution of glacial acetic acid, stirring and extracting for more than 30 hours at the temperature of 5-10 ℃, then carrying out solid-liquid separation to obtain a solid phase and a liquid phase, carrying out rotary evaporation on the liquid phase at the temperature of 70 ℃, and carrying out freeze drying on the residual solid phase to obtain a component I;
(3) Preparing an ethanol solution of protocatechuic acid, soaking the solid phase subjected to solid-liquid separation in the step (2) in the ethanol solution of protocatechuic acid, extracting at a constant temperature in a water bath of 60+/-5 ℃ for 20-26 hours, then air-cooling to normal temperature, performing solid-liquid separation, removing ethanol by rotary evaporation of the liquid phase at 70 ℃, and drying to obtain a component II;
(4) Mixing the first component and the second component to obtain the fructus Schisandrae extract.
Further, in the aqueous solution of glacial acetic acid, the mass percentage of the glacial acetic acid is 10% -12%, and the solid-liquid mass ratio of the mixture added into the aqueous solution of glacial acetic acid is that the mixture/the aqueous solution of glacial acetic acid=1/10-15.
Further, in the ethanol solution of protocatechuic acid, the mass percentage of the protocatechuic acid is 6% -8%, and in the step (3), the solid-liquid mass ratio of the solid phase immersed in the ethanol solution of the protocatechuic acid is solid/liquid=1/10-15.
Further, the components in parts by weight are as follows: 14-18 parts of calcium hydrophosphate, 15-17 parts of hydrated silica, 6-10 parts of sorbitol, 15-20 parts of glycerol, 0.1-0.2 part of sodium monofluorophosphate, 2-3 parts of sodium lauroyl sarcosinate, 1-2 parts of cocamidopropyl betaine, 0.8-1.5 parts of carboxymethyl chitosan, 0.6-0.8 part of cellulose gum, 0.5-0.6 part of licorice powder, 0.5-0.6 part of gardenia powder, 0.02-0.04 part of stevioside, 10-12 parts of schisandra extract, 5-6 parts of essence and 12-16 parts of deionized water.
The preparation method of the oral cavity cleaning toothpaste comprises the following steps:
step one, sterilization: weighing the components according to the parts by weight, and adding deionized water into a sterilizing pot for sterilization;
step two, premixing: sorbitol and glycerol are added into a premixing pot;
Step three, powder feeding: adding the licorice leaf powder, the gardenia powder, the stevioside and the schisandra chinensis extract into a homogenizing container, starting a vacuum pump matched with the homogenizing container, and sucking materials in a sterilizing pot and a premixing pot into the homogenizing container; sucking powder carboxymethyl chitosan, cellulose gum, hydrated silica, calcium hydrophosphate and sodium monofluorophosphate into a corresponding homogenizing container by using a vacuum pump; after powder suction is finished, controlling the vacuum degree P= -0.06MPa to-0.09 MPa, and rapidly stirring for 20min at the temperature T of less than 40 ℃, and stopping stirring after stirring is finished;
Step four, stirring: sucking sodium lauroyl sarcosinate and cocamidopropyl betaine into a corresponding homogenizing container by using a vacuum pump; after powder suction is finished, controlling the vacuum degree P= -0.06MPa to-0.09 MPa, and rapidly stirring for 20min at the temperature T of less than 40 ℃;
Step five, degassing: after stirring, controlling the vacuum degree P= -0.06MPa to-0.09 MPa and the temperature T to be less than 40 ℃, and sucking the essence into a homogenizing container by using a vacuum pump; after the essence is added, homogenizing and degassing are carried out for 20 minutes, and the preparation is finished.
The application has the beneficial effects that: the oral cavity cleaning toothpaste prepared by the method has good whitening effect on teeth and has obvious inhibition effect on staphylococcus aureus. The licorice leaf powder and the gardenia powder are matched with the schisandra chinensis extract to be added into the toothpaste, so that the antibacterial effect and the whitening effect of the toothpaste can be enhanced, and the significance of the antibacterial and whitening effects of the toothpaste is greatly improved.
Detailed Description
The following is a detailed description of embodiments:
Example 1
An oral cavity cleaning toothpaste comprises calcium hydrogen phosphate, hydrated silica, sorbitol, glycerol, sodium monofluorophosphate, sodium lauroyl sarcosinate, cocamidopropyl betaine, carboxymethyl chitosan, cellulose gum, glycyrrhrizae radix leaf powder, gardenia powder, stevioside, fructus Schisandrae extract, essence and deionized water. The components in parts by weight are as follows: 14 parts of calcium hydrophosphate, 15 parts of hydrated silica, 6 parts of sorbitol, 15 parts of glycerin, 0.1 part of sodium monofluorophosphate, 2 parts of sodium lauroyl sarcosine, 1 part of cocamidopropyl betaine, 0.8 part of carboxymethyl chitosan, 0.6 part of cellulose gum, 0.5 part of licorice leaf powder, 0.5 part of gardenia powder, 0.02 part of stevioside, 10 parts of schisandra chinensis extract, 5 parts of essence and 12 parts of deionized water.
Wherein the licorice leaf powder is obtained by sun-drying licorice leaves, grinding into powder, sieving with a 50-mesh sieve. The gardenia powder is obtained by sun-drying gardenia petals, grinding into powder, and sieving with a 50-mesh sieve. The preparation method of the schisandra chinensis extract comprises the following steps:
(1) Separating fructus Schisandrae pulp from kernel, cutting pulp into pieces, pulverizing kernel, and mixing the pieces and kernel powder to obtain a mixture;
(2) Preparing an aqueous solution of glacial acetic acid, wherein the mass percentage of the glacial acetic acid in the aqueous solution of the glacial acetic acid is 10%, adding the mixture into the aqueous solution of the glacial acetic acid, and the solid-liquid mass ratio of the mixture to the aqueous solution of the glacial acetic acid is that the mixture/the aqueous solution of the glacial acetic acid=1/10; stirring and extracting for 30h at the temperature of 5-10 ℃, then carrying out solid-liquid separation to obtain a solid phase and a liquid phase, carrying out rotary evaporation on the liquid phase at the temperature of 70 ℃, and carrying out freeze drying on the residual solid phase to obtain a component I;
(3) Preparing an ethanol solution of protocatechuic acid, wherein the mass percentage of the protocatechuic acid in the ethanol solution of the protocatechuic acid is 6%, soaking the solid phase obtained after solid-liquid separation in the step (2) in the ethanol solution of the protocatechuic acid, and the mass ratio of the solid phase soaked in the ethanol solution of the protocatechuic acid is solid/liquid=1/10; extracting for 20 hours in a water bath at the constant temperature of 60+/-5 ℃, then air-cooling to normal temperature, separating solid from liquid, removing ethanol by rotary evaporation of the liquid phase at the temperature of 70 ℃, and drying to obtain a component II;
(4) Mixing the first component and the second component to obtain the fructus Schisandrae extract.
The preparation method of the oral cavity cleaning toothpaste comprises the following steps:
step one, sterilization: weighing the components according to the parts by weight, and adding deionized water into a sterilizing pot for sterilization;
step two, premixing: sorbitol and glycerol are added into a premixing pot;
Step three, powder feeding: adding the licorice leaf powder, the gardenia powder, the stevioside and the schisandra chinensis extract into a homogenizing container, starting a vacuum pump matched with the homogenizing container, and sucking materials in a sterilizing pot and a premixing pot into the homogenizing container; sucking powder carboxymethyl chitosan, cellulose gum, hydrated silica, calcium hydrophosphate and sodium monofluorophosphate into a corresponding homogenizing container by using a vacuum pump; after powder suction is finished, controlling the vacuum degree P= -0.07MPa, the temperature T = 20 ℃, and rapidly stirring for 20min at 90r/min, and stopping stirring after stirring is finished;
Step four, stirring: sucking sodium lauroyl sarcosinate and cocamidopropyl betaine into a corresponding homogenizing container by using a vacuum pump; after powder suction is finished, controlling the vacuum degree P= -0.07MPa, and rapidly stirring for 20min at the temperature T=20 ℃ and at the speed of 90 r/min;
Step five, degassing: after stirring, controlling the vacuum degree P= -0.07MPa and the temperature T = 20 ℃, and sucking essence into a homogenizing container by using a vacuum pump; after the essence is added, homogenizing and degassing are carried out for 20 minutes, and the preparation is finished.
Example 2
An oral cavity cleaning toothpaste comprises calcium hydrogen phosphate, hydrated silica, sorbitol, glycerol, sodium monofluorophosphate, sodium lauroyl sarcosinate, cocamidopropyl betaine, carboxymethyl chitosan, cellulose gum, glycyrrhrizae radix leaf powder, gardenia powder, stevioside, fructus Schisandrae extract, essence and deionized water. The components in parts by weight are as follows: 15 parts of calcium hydrophosphate, 16 parts of hydrated silica, 8 parts of sorbitol, 17 parts of glycerin, 0.1 part of sodium monofluorophosphate, 2 parts of sodium lauroyl sarcosine, 1 part of cocamidopropyl betaine, 1 part of carboxymethyl chitosan, 0.7 part of cellulose gum, 0.5 part of licorice powder, 0.5 part of gardenia powder, 0.03 part of stevioside, 11 parts of schisandra chinensis extract, 5 parts of essence and 14 parts of deionized water.
Wherein the licorice leaf powder is obtained by sun-drying licorice leaves, grinding into powder, sieving with a 50-mesh sieve. The gardenia powder is obtained by sun-drying gardenia petals, grinding into powder, and sieving with a 50-mesh sieve. The preparation method of the schisandra chinensis extract comprises the following steps:
(1) Separating fructus Schisandrae pulp from kernel, cutting pulp into pieces, pulverizing kernel, and mixing the pieces and kernel powder to obtain a mixture;
(2) Preparing an aqueous solution of glacial acetic acid, wherein the mass percentage of the glacial acetic acid in the aqueous solution of the glacial acetic acid is 11%, adding the mixture into the aqueous solution of the glacial acetic acid, and the solid-liquid mass ratio of the mixture added into the aqueous solution of the glacial acetic acid is that the mixture/the aqueous solution of the glacial acetic acid=1/10; stirring and extracting for 30h at the temperature of 5-10 ℃, then carrying out solid-liquid separation to obtain a solid phase and a liquid phase, carrying out rotary evaporation on the liquid phase at the temperature of 70 ℃, and carrying out freeze drying on the residual solid phase to obtain a component I;
(3) Preparing an ethanol solution of protocatechuic acid, wherein the mass percentage of the protocatechuic acid in the ethanol solution of the protocatechuic acid is 7%, soaking the solid phase obtained after solid-liquid separation in the step (2) in the ethanol solution of the protocatechuic acid, and the mass ratio of the solid phase soaked in the ethanol solution of the protocatechuic acid is solid/liquid=1/10; extracting for 20 hours in a water bath at the constant temperature of 60+/-5 ℃, then air-cooling to normal temperature, separating solid from liquid, removing ethanol by rotary evaporation of the liquid phase at the temperature of 70 ℃, and drying to obtain a component II;
(4) Mixing the first component and the second component to obtain the fructus Schisandrae extract.
The preparation method of the oral cavity cleaning toothpaste comprises the following steps:
step one, sterilization: weighing the components according to the parts by weight, and adding deionized water into a sterilizing pot for sterilization;
step two, premixing: sorbitol and glycerol are added into a premixing pot;
Step three, powder feeding: adding the licorice leaf powder, the gardenia powder, the stevioside and the schisandra chinensis extract into a homogenizing container, starting a vacuum pump matched with the homogenizing container, and sucking materials in a sterilizing pot and a premixing pot into the homogenizing container; sucking powder carboxymethyl chitosan, cellulose gum, hydrated silica, calcium hydrophosphate and sodium monofluorophosphate into a corresponding homogenizing container by using a vacuum pump; after powder suction is finished, controlling the vacuum degree P= -0.07MPa, the temperature T = 20 ℃, and rapidly stirring for 20min at 90r/min, and stopping stirring after stirring is finished;
Step four, stirring: sucking sodium lauroyl sarcosinate and cocamidopropyl betaine into a corresponding homogenizing container by using a vacuum pump; after powder suction is finished, controlling the vacuum degree P= -0.07MPa, and rapidly stirring for 20min at the temperature T=20 ℃ and at the speed of 90 r/min;
Step five, degassing: after stirring, controlling the vacuum degree P= -0.07MPa and the temperature T = 20 ℃, and sucking essence into a homogenizing container by using a vacuum pump; after the essence is added, homogenizing and degassing are carried out for 20 minutes, and the preparation is finished.
Example 3
An oral cavity cleaning toothpaste comprises calcium hydrogen phosphate, hydrated silica, sorbitol, glycerol, sodium monofluorophosphate, sodium lauroyl sarcosinate, cocamidopropyl betaine, carboxymethyl chitosan, cellulose gum, glycyrrhrizae radix leaf powder, gardenia powder, stevioside, fructus Schisandrae extract, essence and deionized water. The components in parts by weight are as follows: 17 parts of calcium hydrophosphate, 16 parts of hydrated silica, 8 parts of sorbitol, 18 parts of glycerin, 0.2 part of sodium monofluorophosphate, 3 parts of sodium lauroyl sarcosine, 2 parts of cocamidopropyl betaine, 1.2 parts of carboxymethyl chitosan, 0.7 part of cellulose gum, 0.6 part of licorice powder, 0.6 part of gardenia powder, 0.03 part of stevioside, 11 parts of schisandra chinensis extract, 6 parts of essence and 14 parts of deionized water.
Wherein the licorice leaf powder is obtained by sun-drying licorice leaves, grinding into powder, sieving with a 50-mesh sieve. The gardenia powder is obtained by sun-drying gardenia petals, grinding into powder, and sieving with a 50-mesh sieve. The preparation method of the schisandra chinensis extract comprises the following steps:
(1) Separating fructus Schisandrae pulp from kernel, cutting pulp into pieces, pulverizing kernel, and mixing the pieces and kernel powder to obtain a mixture;
(2) Preparing an aqueous solution of glacial acetic acid, wherein the mass percentage of the glacial acetic acid in the aqueous solution of the glacial acetic acid is 11%, adding the mixture into the aqueous solution of the glacial acetic acid, and the solid-liquid mass ratio of the mixture added into the aqueous solution of the glacial acetic acid is that the mixture/the aqueous solution of the glacial acetic acid=1/10; stirring and extracting for 30h at the temperature of 5-10 ℃, then carrying out solid-liquid separation to obtain a solid phase and a liquid phase, carrying out rotary evaporation on the liquid phase at the temperature of 70 ℃, and carrying out freeze drying on the residual solid phase to obtain a component I;
(3) Preparing an ethanol solution of protocatechuic acid, wherein the mass percentage of the protocatechuic acid in the ethanol solution of the protocatechuic acid is 7%, soaking the solid phase obtained after solid-liquid separation in the step (2) in the ethanol solution of the protocatechuic acid, and the mass ratio of the solid phase soaked in the ethanol solution of the protocatechuic acid is solid/liquid=1/10; extracting for 20 hours in a water bath at the constant temperature of 60+/-5 ℃, then air-cooling to normal temperature, separating solid from liquid, removing ethanol by rotary evaporation of the liquid phase at the temperature of 70 ℃, and drying to obtain a component II;
(4) Mixing the first component and the second component to obtain the fructus Schisandrae extract.
The preparation method of the oral cavity cleaning toothpaste comprises the following steps:
step one, sterilization: weighing the components according to the parts by weight, and adding deionized water into a sterilizing pot for sterilization;
step two, premixing: sorbitol and glycerol are added into a premixing pot;
Step three, powder feeding: adding the licorice leaf powder, the gardenia powder, the stevioside and the schisandra chinensis extract into a homogenizing container, starting a vacuum pump matched with the homogenizing container, and sucking materials in a sterilizing pot and a premixing pot into the homogenizing container; sucking powder carboxymethyl chitosan, cellulose gum, hydrated silica, calcium hydrophosphate and sodium monofluorophosphate into a corresponding homogenizing container by using a vacuum pump; after powder suction is finished, controlling the vacuum degree P= -0.07MPa, the temperature T = 20 ℃, and rapidly stirring for 20min at 90r/min, and stopping stirring after stirring is finished;
Step four, stirring: sucking sodium lauroyl sarcosinate and cocamidopropyl betaine into a corresponding homogenizing container by using a vacuum pump; after powder suction is finished, controlling the vacuum degree P= -0.07MPa, and rapidly stirring for 20min at the temperature T=20 ℃ and at the speed of 90 r/min;
Step five, degassing: after stirring, controlling the vacuum degree P= -0.07MPa and the temperature T = 20 ℃, and sucking essence into a homogenizing container by using a vacuum pump; after the essence is added, homogenizing and degassing are carried out for 20 minutes, and the preparation is finished.
Example 4
An oral cavity cleaning toothpaste comprises calcium hydrogen phosphate, hydrated silica, sorbitol, glycerol, sodium monofluorophosphate, sodium lauroyl sarcosinate, cocamidopropyl betaine, carboxymethyl chitosan, cellulose gum, glycyrrhrizae radix leaf powder, gardenia powder, stevioside, fructus Schisandrae extract, essence and deionized water. The components in parts by weight are as follows: 18 parts of calcium hydrophosphate, 17 parts of hydrated silica, 10 parts of sorbitol, 20 parts of glycerin, 0.2 part of sodium monofluorophosphate, 3 parts of sodium lauroyl sarcosine, 2 parts of cocamidopropyl betaine, 1.5 parts of carboxymethyl chitosan, 0.8 part of cellulose gum, 0.6 part of licorice leaf powder, 0.6 part of gardenia powder, 0.04 part of stevioside, 12 parts of schisandra chinensis extract, 6 parts of essence and 16 parts of deionized water.
Wherein the licorice leaf powder is obtained by sun-drying licorice leaves, grinding into powder, sieving with a 50-mesh sieve. The gardenia powder is obtained by sun-drying gardenia petals, grinding into powder, and sieving with a 50-mesh sieve. The preparation method of the schisandra chinensis extract comprises the following steps:
(1) Separating fructus Schisandrae pulp from kernel, cutting pulp into pieces, pulverizing kernel, and mixing the pieces and kernel powder to obtain a mixture;
(2) Preparing an aqueous solution of glacial acetic acid, wherein the mass percentage of the glacial acetic acid in the aqueous solution of the glacial acetic acid is 12%, adding the mixture into the aqueous solution of the glacial acetic acid, and the solid-liquid mass ratio of the mixture added into the aqueous solution of the glacial acetic acid is that the mixture/the aqueous solution of the glacial acetic acid=1/10; stirring and extracting for 30h at the temperature of 5-10 ℃, then carrying out solid-liquid separation to obtain a solid phase and a liquid phase, carrying out rotary evaporation on the liquid phase at the temperature of 70 ℃, and carrying out freeze drying on the residual solid phase to obtain a component I;
(3) Preparing an ethanol solution of protocatechuic acid, wherein the mass percentage of the protocatechuic acid in the ethanol solution of the protocatechuic acid is 8%, soaking the solid phase obtained after solid-liquid separation in the step (2) in the ethanol solution of the protocatechuic acid, and the mass ratio of the solid phase soaked in the ethanol solution of the protocatechuic acid is solid/liquid=1/10; extracting for 20 hours in a water bath at the constant temperature of 60+/-5 ℃, then air-cooling to normal temperature, separating solid from liquid, removing ethanol by rotary evaporation of the liquid phase at the temperature of 70 ℃, and drying to obtain a component II;
(4) Mixing the first component and the second component to obtain the fructus Schisandrae extract.
The preparation method of the oral cavity cleaning toothpaste comprises the following steps:
step one, sterilization: weighing the components according to the parts by weight, and adding deionized water into a sterilizing pot for sterilization;
step two, premixing: sorbitol and glycerol are added into a premixing pot;
Step three, powder feeding: adding the licorice leaf powder, the gardenia powder, the stevioside and the schisandra chinensis extract into a homogenizing container, starting a vacuum pump matched with the homogenizing container, and sucking materials in a sterilizing pot and a premixing pot into the homogenizing container; sucking powder carboxymethyl chitosan, cellulose gum, hydrated silica, calcium hydrophosphate and sodium monofluorophosphate into a corresponding homogenizing container by using a vacuum pump; after powder suction is finished, controlling the vacuum degree P= -0.07MPa, the temperature T = 20 ℃, and rapidly stirring for 20min at 90r/min, and stopping stirring after stirring is finished;
Step four, stirring: sucking sodium lauroyl sarcosinate and cocamidopropyl betaine into a corresponding homogenizing container by using a vacuum pump; after powder suction is finished, controlling the vacuum degree P= -0.07MPa, and rapidly stirring for 20min at the temperature T=20 ℃ and at the speed of 90 r/min;
Step five, degassing: after stirring, controlling the vacuum degree P= -0.07MPa and the temperature T = 20 ℃, and sucking essence into a homogenizing container by using a vacuum pump; after the essence is added, homogenizing and degassing are carried out for 20 minutes, and the preparation is finished.
Comparative example 1
A toothpaste for comparison comprises calcium hydrogen phosphate, hydrated silica, sorbitol, glycerol, sodium monofluorophosphate, sodium lauroyl sarcosinate, cocamidopropyl betaine, carboxymethyl chitosan, cellulose gum, gardenia powder, stevioside, fructus Schisandrae extract, essence and deionized water. The components in parts by weight are as follows: 17 parts of calcium hydrophosphate, 16 parts of hydrated silica, 8 parts of sorbitol, 18 parts of glycerin, 0.2 part of sodium monofluorophosphate, 3 parts of sodium lauroyl sarcosine, 2 parts of cocamidopropyl betaine, 1.2 parts of carboxymethyl chitosan, 0.7 part of cellulose gum, 0.6 part of gardenia powder, 0.03 part of stevioside, 11 parts of schisandra extract, 6 parts of essence and 14 parts of deionized water.
Wherein the gardenia powder is obtained by sun-drying gardenia petals, grinding into powder, and sieving with a 50-mesh sieve. The preparation method of the schisandra chinensis extract comprises the following steps:
(1) Separating fructus Schisandrae pulp from kernel, cutting pulp into pieces, pulverizing kernel, and mixing the pieces and kernel powder to obtain a mixture;
(2) Preparing an aqueous solution of glacial acetic acid, wherein the mass percentage of the glacial acetic acid in the aqueous solution of the glacial acetic acid is 11%, adding the mixture into the aqueous solution of the glacial acetic acid, and the solid-liquid mass ratio of the mixture added into the aqueous solution of the glacial acetic acid is that the mixture/the aqueous solution of the glacial acetic acid=1/10; stirring and extracting for 30h at the temperature of 5-10 ℃, then carrying out solid-liquid separation to obtain a solid phase and a liquid phase, carrying out rotary evaporation on the liquid phase at the temperature of 70 ℃, and carrying out freeze drying on the residual solid phase to obtain a component I;
(3) Preparing an ethanol solution of protocatechuic acid, wherein the mass percentage of the protocatechuic acid in the ethanol solution of the protocatechuic acid is 7%, soaking the solid phase obtained after solid-liquid separation in the step (2) in the ethanol solution of the protocatechuic acid, and the mass ratio of the solid phase soaked in the ethanol solution of the protocatechuic acid is solid/liquid=1/10; extracting for 20 hours in a water bath at the constant temperature of 60+/-5 ℃, then air-cooling to normal temperature, separating solid from liquid, removing ethanol by rotary evaporation of the liquid phase at the temperature of 70 ℃, and drying to obtain a component II;
(4) Mixing the first component and the second component to obtain the fructus Schisandrae extract.
The preparation method of the toothpaste comprises the following steps:
step one, sterilization: weighing the components according to the parts by weight, and adding deionized water into a sterilizing pot for sterilization;
step two, premixing: sorbitol and glycerol are added into a premixing pot;
step three, powder feeding: adding the gardenia powder, the stevioside and the schisandra chinensis extract into a homogenizing container, starting a vacuum pump matched with the homogenizing container, and sucking materials in a sterilizing pot and a premixing pot into the homogenizing container; sucking powder carboxymethyl chitosan, cellulose gum, hydrated silica, calcium hydrophosphate and sodium monofluorophosphate into a corresponding homogenizing container by using a vacuum pump; after powder suction is finished, controlling the vacuum degree P= -0.07MPa, the temperature T = 20 ℃, and rapidly stirring for 20min at 90r/min, and stopping stirring after stirring is finished;
Step four, stirring: sucking sodium lauroyl sarcosinate and cocamidopropyl betaine into a corresponding homogenizing container by using a vacuum pump; after powder suction is finished, controlling the vacuum degree P= -0.07MPa, and rapidly stirring for 20min at the temperature T=20 ℃ and at the speed of 90 r/min;
Step five, degassing: after stirring, controlling the vacuum degree P= -0.07MPa and the temperature T = 20 ℃, and sucking essence into a homogenizing container by using a vacuum pump; after the essence is added, homogenizing and degassing are carried out for 20 minutes, and the preparation is finished.
Comparative example 2
A toothpaste for comparison comprises calcium hydrogen phosphate, hydrated silica, sorbitol, glycerol, sodium monofluorophosphate, sodium lauroyl sarcosinate, cocamidopropyl betaine, carboxymethyl chitosan, cellulose gum, licorice leaf powder, stevioside, fructus Schisandrae extract, essence and deionized water. The components in parts by weight are as follows: 17 parts of calcium hydrophosphate, 16 parts of hydrated silica, 8 parts of sorbitol, 18 parts of glycerin, 0.2 part of sodium monofluorophosphate, 3 parts of sodium lauroyl sarcosine, 2 parts of cocamidopropyl betaine, 1.2 parts of carboxymethyl chitosan, 0.7 part of cellulose gum, 0.6 part of licorice powder, 0.03 part of stevioside, 11 parts of schisandra chinensis extract, 6 parts of essence and 14 parts of deionized water.
Wherein the licorice leaf powder is obtained by sun-drying licorice leaves, grinding into powder, sieving with a 50-mesh sieve. The preparation method of the schisandra chinensis extract comprises the following steps:
(1) Separating fructus Schisandrae pulp from kernel, cutting pulp into pieces, pulverizing kernel, and mixing the pieces and kernel powder to obtain a mixture;
(2) Preparing an aqueous solution of glacial acetic acid, wherein the mass percentage of the glacial acetic acid in the aqueous solution of the glacial acetic acid is 11%, adding the mixture into the aqueous solution of the glacial acetic acid, and the solid-liquid mass ratio of the mixture added into the aqueous solution of the glacial acetic acid is that the mixture/the aqueous solution of the glacial acetic acid=1/10; stirring and extracting for 30h at the temperature of 5-10 ℃, then carrying out solid-liquid separation to obtain a solid phase and a liquid phase, carrying out rotary evaporation on the liquid phase at the temperature of 70 ℃, and carrying out freeze drying on the residual solid phase to obtain a component I;
(3) Preparing an ethanol solution of protocatechuic acid, wherein the mass percentage of the protocatechuic acid in the ethanol solution of the protocatechuic acid is 7%, soaking the solid phase obtained after solid-liquid separation in the step (2) in the ethanol solution of the protocatechuic acid, and the mass ratio of the solid phase soaked in the ethanol solution of the protocatechuic acid is solid/liquid=1/10; extracting for 20 hours in a water bath at the constant temperature of 60+/-5 ℃, then air-cooling to normal temperature, separating solid from liquid, removing ethanol by rotary evaporation of the liquid phase at the temperature of 70 ℃, and drying to obtain a component II;
(4) Mixing the first component and the second component to obtain the fructus Schisandrae extract.
The preparation method of the toothpaste comprises the following steps:
step one, sterilization: weighing the components according to the parts by weight, and adding deionized water into a sterilizing pot for sterilization;
step two, premixing: sorbitol and glycerol are added into a premixing pot;
Step three, powder feeding: adding the licorice leaf powder, the stevioside and the schisandra chinensis extract into a homogenizing container, starting a vacuum pump matched with the homogenizing container, and sucking materials in a sterilizing pot and a premixing pot into the homogenizing container; sucking powder carboxymethyl chitosan, cellulose gum, hydrated silica, calcium hydrophosphate and sodium monofluorophosphate into a corresponding homogenizing container by using a vacuum pump; after powder suction is finished, controlling the vacuum degree P= -0.07MPa, the temperature T = 20 ℃, and rapidly stirring for 20min at 90r/min, and stopping stirring after stirring is finished;
Step four, stirring: sucking sodium lauroyl sarcosinate and cocamidopropyl betaine into a corresponding homogenizing container by using a vacuum pump; after powder suction is finished, controlling the vacuum degree P= -0.07MPa, and rapidly stirring for 20min at the temperature T=20 ℃ and at the speed of 90 r/min;
Step five, degassing: after stirring, controlling the vacuum degree P= -0.07MPa and the temperature T = 20 ℃, and sucking essence into a homogenizing container by using a vacuum pump; after the essence is added, homogenizing and degassing are carried out for 20 minutes, and the preparation is finished.
Comparative example 3
A toothpaste for comparison comprises calcium hydrogen phosphate, hydrated silica, sorbitol, glycerol, sodium monofluorophosphate, sodium lauroyl sarcosinate, cocamidopropyl betaine, carboxymethyl chitosan, cellulose gum, licorice leaf powder, gardenia powder, stevioside, essence and deionized water. The components in parts by weight are as follows: 17 parts of calcium hydrophosphate, 16 parts of hydrated silica, 8 parts of sorbitol, 18 parts of glycerin, 0.2 part of sodium monofluorophosphate, 3 parts of sodium lauroyl sarcosine, 2 parts of cocamidopropyl betaine, 1.2 parts of carboxymethyl chitosan, 0.7 part of cellulose gum, 0.6 part of licorice powder, 0.6 part of gardenia powder, 0.03 part of stevioside, 6 parts of essence and 14 parts of deionized water.
Wherein the licorice leaf powder is obtained by sun-drying licorice leaves, grinding into powder, sieving with a 50-mesh sieve. The gardenia powder is obtained by sun-drying gardenia petals, grinding into powder, and sieving with a 50-mesh sieve.
The preparation method of the toothpaste comprises the following steps:
step one, sterilization: weighing the components according to the parts by weight, and adding deionized water into a sterilizing pot for sterilization;
step two, premixing: sorbitol and glycerol are added into a premixing pot;
Step three, powder feeding: adding the licorice leaf powder, the gardenia powder and the stevioside into a homogenizing container, starting a vacuum pump matched with the homogenizing container, and sucking materials in a sterilizing pot and a premixing pot into the homogenizing container; sucking powder carboxymethyl chitosan, cellulose gum, hydrated silica, calcium hydrophosphate and sodium monofluorophosphate into a corresponding homogenizing container by using a vacuum pump; after powder suction is finished, controlling the vacuum degree P= -0.07MPa, the temperature T = 20 ℃, and rapidly stirring for 20min at 90r/min, and stopping stirring after stirring is finished;
Step four, stirring: sucking sodium lauroyl sarcosinate and cocamidopropyl betaine into a corresponding homogenizing container by using a vacuum pump; after powder suction is finished, controlling the vacuum degree P= -0.07MPa, and rapidly stirring for 20min at the temperature T=20 ℃ and at the speed of 90 r/min;
Step five, degassing: after stirring, controlling the vacuum degree P= -0.07MPa and the temperature T = 20 ℃, and sucking essence into a homogenizing container by using a vacuum pump; after the essence is added, homogenizing and degassing are carried out for 20 minutes, and the preparation is finished.
Comparative example 4
A toothpaste for comparison comprises calcium hydrogen phosphate, hydrated silica, sorbitol, glycerol, sodium monofluorophosphate, sodium lauroyl sarcosinate, cocamidopropyl betaine, carboxymethyl chitosan, cellulose gum, licorice leaf powder, gardenia powder, stevioside, fructus Schisandrae extract, essence and deionized water. The components in parts by weight are as follows: 17 parts of calcium hydrophosphate, 16 parts of hydrated silica, 8 parts of sorbitol, 18 parts of glycerin, 0.2 part of sodium monofluorophosphate, 3 parts of sodium lauroyl sarcosine, 2 parts of cocamidopropyl betaine, 1.2 parts of carboxymethyl chitosan, 0.7 part of cellulose gum, 0.6 part of licorice powder, 0.6 part of gardenia powder, 0.03 part of stevioside, 11 parts of schisandra chinensis extract, 6 parts of essence and 14 parts of deionized water.
Wherein the licorice leaf powder is obtained by sun-drying licorice leaves, grinding into powder, sieving with a 50-mesh sieve. The gardenia powder is obtained by sun-drying gardenia petals, grinding into powder, and sieving with a 50-mesh sieve. The preparation method of the schisandra chinensis extract comprises the following steps:
(1) Separating fructus Schisandrae pulp from kernel, cutting pulp into pieces, pulverizing kernel, and mixing the pieces and kernel powder to obtain a mixture;
(2) Preparing an aqueous solution of glacial acetic acid, wherein the mass percentage of the glacial acetic acid in the aqueous solution of the glacial acetic acid is 11%, adding the mixture into the aqueous solution of the glacial acetic acid, and the solid-liquid mass ratio of the mixture added into the aqueous solution of the glacial acetic acid is that the mixture/the aqueous solution of the glacial acetic acid=1/10; stirring and extracting for 30h at the temperature of 5-10 ℃, then carrying out solid-liquid separation to obtain a solid phase and a liquid phase, carrying out rotary evaporation on the liquid phase at the temperature of 70 ℃, and carrying out freeze drying on the residual solid phase to obtain a component I;
(3) Soaking the solid phase subjected to the solid-liquid separation in the step (2) in ethanol, wherein the mass ratio of the solid phase soaked in the ethanol is solid/liquid=1/10; extracting for 20 hours in a water bath at the constant temperature of 60+/-5 ℃, then air-cooling to normal temperature, separating solid from liquid, removing ethanol by rotary evaporation of the liquid phase at the temperature of 70 ℃, and drying to obtain a component II;
(4) Mixing the first component and the second component to obtain the fructus Schisandrae extract.
The preparation method of the toothpaste comprises the following steps:
step one, sterilization: weighing the components according to the parts by weight, and adding deionized water into a sterilizing pot for sterilization;
step two, premixing: sorbitol and glycerol are added into a premixing pot;
Step three, powder feeding: adding the licorice leaf powder, the gardenia powder, the stevioside and the schisandra chinensis extract into a homogenizing container, starting a vacuum pump matched with the homogenizing container, and sucking materials in a sterilizing pot and a premixing pot into the homogenizing container; sucking powder carboxymethyl chitosan, cellulose gum, hydrated silica, calcium hydrophosphate and sodium monofluorophosphate into a corresponding homogenizing container by using a vacuum pump; after powder suction is finished, controlling the vacuum degree P= -0.07MPa, the temperature T = 20 ℃, and rapidly stirring for 20min at 90r/min, and stopping stirring after stirring is finished;
Step four, stirring: sucking sodium lauroyl sarcosinate and cocamidopropyl betaine into a corresponding homogenizing container by using a vacuum pump; after powder suction is finished, controlling the vacuum degree P= -0.07MPa, and rapidly stirring for 20min at the temperature T=20 ℃ and at the speed of 90 r/min;
Step five, degassing: after stirring, controlling the vacuum degree P= -0.07MPa and the temperature T = 20 ℃, and sucking essence into a homogenizing container by using a vacuum pump; after the essence is added, homogenizing and degassing are carried out for 20 minutes, and the preparation is finished.
Example 5
The whitening effect of the toothpaste described in each of the above examples and comparative examples was verified by testing and calculating PCR values using a biofilm cleaning rate experimental model method. The results are shown in Table 1. In addition, antibacterial experiments were performed on the toothpastes described in the above examples and comparative examples: adding a culture medium into a culture dish, sucking staphylococcus aureus suspension into the culture medium in the culture dish by a pipette after the culture medium is solidified, and uniformly smearing by a coating rod. A round filter paper sheet coated with toothpaste to be tested is placed on a culture medium with staphylococcus aureus suspension, the diameter of the filter paper sheet is 7mm, and 50mg of toothpaste is uniformly smeared on each filter paper sheet. The petri dish was sealed with a sealing film and incubated at 37℃for 24 hours. The diameter of the inhibition zone was then measured by the crisscross method for evaluation of bactericidal activity, and the results are shown in table 1.
TABLE 1
As shown in Table 1, the oral cleaning toothpaste provided by the invention has a good whitening effect on teeth and has an obvious inhibition effect on staphylococcus aureus. Comparative example 3 and comparative example it is known that whitening effect and antibacterial property of toothpaste can be remarkably improved by adding the schisandra chinensis extract of the present invention. The licorice leaf powder and the gardenia powder mainly have promoting effect on the antibacterial effect of the toothpaste, and have relatively small promoting effect on whitening teeth.
The foregoing detailed description of the embodiments of the present invention will be provided to those skilled in the art, and the detailed description and the examples should not be construed as limiting the invention.
Claims (4)
1. The oral cavity cleaning toothpaste is characterized by comprising the following components in parts by weight: 14-18 parts of calcium hydrophosphate, 15-17 parts of hydrated silica, 6-10 parts of sorbitol, 15-20 parts of glycerol, 0.1-0.2 part of sodium monofluorophosphate, 2-3 parts of sodium lauroyl sarcosinate, 1-2 parts of cocamidopropyl betaine, 0.8-1.5 parts of carboxymethyl chitosan, 0.6-0.8 part of cellulose gum, 0.5-0.6 part of licorice powder, 0.5-0.6 part of gardenia powder, 0.02-0.04 part of stevioside, 10-12 parts of schisandra extract, 5-6 parts of essence and 12-16 parts of deionized water; the licorice leaf powder is sieved powder obtained by sieving licorice leaves with a 50-mesh sieve after sun drying and grinding the licorice leaves into powder; the gardenia powder is obtained by sun-drying gardenia petals, grinding into powder, and sieving with a 50-mesh sieve; the preparation method of the schisandra chinensis extract comprises the following steps: (1) Separating fructus Schisandrae pulp from kernel, cutting pulp into pieces, pulverizing kernel, and mixing the pieces and kernel powder to obtain a mixture; (2) Preparing an aqueous solution of glacial acetic acid, adding the mixture into the aqueous solution of glacial acetic acid, stirring and extracting for more than 30 hours at the temperature of 5-10 ℃, then carrying out solid-liquid separation to obtain a solid phase and a liquid phase, carrying out rotary evaporation on the liquid phase at the temperature of 70 ℃, and carrying out freeze drying on the residual solid phase to obtain a component I; (3) Preparing an ethanol solution of protocatechuic acid, soaking the solid phase subjected to solid-liquid separation in the step (2) in the ethanol solution of protocatechuic acid, extracting at a constant temperature in a water bath of 60+/-5 ℃ for 20-26 hours, then air-cooling to normal temperature, performing solid-liquid separation, removing ethanol by rotary evaporation of the liquid phase at 70 ℃, and drying to obtain a component II; (4) Mixing the first component and the second component to obtain the fructus Schisandrae extract.
2. An oral cleaning toothpaste according to claim 1, wherein: the mass percentage of the glacial acetic acid in the aqueous solution of the glacial acetic acid is 10-12%, and the solid-liquid mass ratio of the mixture to the aqueous solution of the glacial acetic acid is 1/10-15.
3. An oral cleaning toothpaste according to claim 2, wherein: in the ethanol solution of the protocatechuic acid, the mass percentage of the protocatechuic acid is 6-8%, and in the step (3), the solid-liquid mass ratio of the solid phase immersed in the ethanol solution of the protocatechuic acid is solid/liquid=1/10-15.
4. The method of preparing an oral cleaning dentifrice according to claim 1, wherein: comprises the following steps:
step one, sterilization: weighing the components according to the parts by weight, and adding deionized water into a sterilizing pot for sterilization;
step two, premixing: sorbitol and glycerol are added into a premixing pot;
Step three, powder feeding: adding the licorice leaf powder, the gardenia powder, the stevioside and the schisandra chinensis extract into a homogenizing container, starting a vacuum pump matched with the homogenizing container, and sucking materials in a sterilizing pot and a premixing pot into the homogenizing container; sucking powder carboxymethyl chitosan, cellulose gum, hydrated silica, calcium hydrophosphate and sodium monofluorophosphate into a corresponding homogenizing container by using a vacuum pump; after powder suction is finished, controlling the vacuum degree P= -0.06MPa to-0.09 MPa, and rapidly stirring for 20min at the temperature T of less than 40 ℃, and stopping stirring after stirring is finished;
Step four, stirring: sucking sodium lauroyl sarcosinate and cocamidopropyl betaine into a corresponding homogenizing container by using a vacuum pump; after powder suction is finished, controlling the vacuum degree P= -0.06MPa to-0.09 MPa, and rapidly stirring for 20min at the temperature T of less than 40 ℃;
Step five, degassing: after stirring, controlling the vacuum degree P= -0.06MPa to-0.09 MPa and the temperature T to be less than 40 ℃, and sucking the essence into a homogenizing container by using a vacuum pump; after the essence is added, homogenizing and degassing are carried out for 20 minutes, and the preparation is finished.
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| 响应面法优化冰醋酸提取五味子果仁抗菌肽工艺研究;武威等;《中国酿造》;第35卷(第6期);第109-112页 * |
| 新疆胀果甘草叶化学成分研究及湖北省不同生态区烟草质量评价;曾小英;《中国优秀硕士论文全文数据库·农业科技辑》(第6期);第16-20页 * |
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