CN115282331A - Waterproof antibacterial liquid band-aid capable of quickly forming film and preparation method thereof - Google Patents
Waterproof antibacterial liquid band-aid capable of quickly forming film and preparation method thereof Download PDFInfo
- Publication number
- CN115282331A CN115282331A CN202211219661.4A CN202211219661A CN115282331A CN 115282331 A CN115282331 A CN 115282331A CN 202211219661 A CN202211219661 A CN 202211219661A CN 115282331 A CN115282331 A CN 115282331A
- Authority
- CN
- China
- Prior art keywords
- aid
- polyvinyl butyral
- stirring
- film
- liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007788 liquid Substances 0.000 title claims abstract description 82
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 34
- 238000002360 preparation method Methods 0.000 title abstract description 20
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 59
- 239000001913 cellulose Substances 0.000 claims abstract description 58
- 229920002678 cellulose Polymers 0.000 claims abstract description 58
- 229920002037 poly(vinyl butyral) polymer Polymers 0.000 claims abstract description 52
- 238000003756 stirring Methods 0.000 claims abstract description 43
- 239000004359 castor oil Substances 0.000 claims abstract description 22
- 235000019438 castor oil Nutrition 0.000 claims abstract description 22
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims abstract description 22
- MRUAUOIMASANKQ-UHFFFAOYSA-O carboxymethyl-[3-(dodecanoylamino)propyl]-dimethylazanium Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC(O)=O MRUAUOIMASANKQ-UHFFFAOYSA-O 0.000 claims abstract description 20
- 229940075468 lauramidopropyl betaine Drugs 0.000 claims abstract description 20
- 229920002413 Polyhexanide Polymers 0.000 claims abstract description 19
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 33
- ZTQSAGDEMFDKMZ-UHFFFAOYSA-N Butyraldehyde Chemical compound CCCC=O ZTQSAGDEMFDKMZ-UHFFFAOYSA-N 0.000 claims description 32
- 239000000725 suspension Substances 0.000 claims description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 30
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 27
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 26
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 26
- 239000007864 aqueous solution Substances 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 17
- HGBOYTHUEUWSSQ-UHFFFAOYSA-N valeric aldehyde Natural products CCCCC=O HGBOYTHUEUWSSQ-UHFFFAOYSA-N 0.000 claims description 16
- 239000000084 colloidal system Substances 0.000 claims description 14
- 230000008569 process Effects 0.000 claims description 14
- 239000000243 solution Substances 0.000 claims description 14
- 238000005406 washing Methods 0.000 claims description 13
- 235000021355 Stearic acid Nutrition 0.000 claims description 11
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 11
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 11
- 239000008117 stearic acid Substances 0.000 claims description 11
- 238000009210 therapy by ultrasound Methods 0.000 claims description 11
- 235000019441 ethanol Nutrition 0.000 claims description 10
- 239000000835 fiber Substances 0.000 claims description 10
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 9
- 239000003513 alkali Substances 0.000 claims description 9
- VZDYWEUILIUIDF-UHFFFAOYSA-J cerium(4+);disulfate Chemical compound [Ce+4].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O VZDYWEUILIUIDF-UHFFFAOYSA-J 0.000 claims description 9
- 229910000355 cerium(IV) sulfate Inorganic materials 0.000 claims description 9
- 238000001035 drying Methods 0.000 claims description 8
- 230000004048 modification Effects 0.000 claims description 8
- 238000012986 modification Methods 0.000 claims description 8
- 230000008961 swelling Effects 0.000 claims description 8
- 239000008367 deionised water Substances 0.000 claims description 7
- 229910021641 deionized water Inorganic materials 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 6
- 206010042674 Swelling Diseases 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 7
- 238000007599 discharging Methods 0.000 abstract description 6
- 206010052428 Wound Diseases 0.000 description 24
- 208000027418 Wounds and injury Diseases 0.000 description 24
- ILRSCQWREDREME-UHFFFAOYSA-N dodecanamide Chemical compound CCCCCCCCCCCC(N)=O ILRSCQWREDREME-UHFFFAOYSA-N 0.000 description 8
- 230000003472 neutralizing effect Effects 0.000 description 6
- 239000002244 precipitate Substances 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 5
- 239000001257 hydrogen Substances 0.000 description 5
- 229910052739 hydrogen Inorganic materials 0.000 description 5
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 5
- 229930182490 saponin Natural products 0.000 description 5
- 150000007949 saponins Chemical class 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 229940116335 lauramide Drugs 0.000 description 4
- HLERILKGMXJNBU-UHFFFAOYSA-N norvaline betaine Chemical compound CCCC(C([O-])=O)[N+](C)(C)C HLERILKGMXJNBU-UHFFFAOYSA-N 0.000 description 4
- -1 polyhexamethylene guanidine hydrochloride Polymers 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- 229930182555 Penicillin Natural products 0.000 description 3
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
- 230000035876 healing Effects 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 229940049954 penicillin Drugs 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 125000003277 amino group Chemical group 0.000 description 2
- PGJHGXFYDZHMAV-UHFFFAOYSA-K azanium;cerium(3+);disulfate Chemical group [NH4+].[Ce+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O PGJHGXFYDZHMAV-UHFFFAOYSA-K 0.000 description 2
- 238000005452 bending Methods 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 239000011259 mixed solution Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 235000019737 Animal fat Nutrition 0.000 description 1
- 206010005908 Body temperature conditions Diseases 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 206010063560 Excessive granulation tissue Diseases 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 206010048038 Wound infection Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 230000005587 bubbling Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000010227 cup method (microbiological evaluation) Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 210000001126 granulation tissue Anatomy 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 125000001841 imino group Chemical group [H]N=* 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 238000003760 magnetic stirring Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 239000003357 wound healing promoting agent Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0057—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0085—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
- A61L2300/206—Biguanides, e.g. chlorohexidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/21—Acids
- A61L2300/214—Amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
Abstract
A waterproof antibacterial liquid band-aid capable of quickly forming a film and a preparation method thereof. The invention belongs to the technical field of medical dressing. The invention aims to solve the technical problems of slow film forming time, poor film forming effect, easy falling and air impermeability of the existing liquid band-aid. The liquid band-aid is prepared from ethanol, polyvinyl butyral, modified cellulose, castor oil, polyhexamethylene biguanide hydrochloride and lauramidopropyl betaine. The preparation method comprises the following steps: adding polyvinyl butyral into ethanol, stirring until the polyvinyl butyral is completely dissolved, then adding modified cellulose, stirring until the polyvinyl butyral is completely dissolved, ultrasonically discharging bubbles, sequentially adding castor oil, polyhexamethylene biguanide hydrochloride and lauramidopropyl betaine, and continuously stirring until the castor oil, the polyhexamethylene biguanide hydrochloride and the lauramidopropyl betaine are uniformly mixed to obtain the waterproof, antibacterial and quick-film-forming liquid band-aid.
Description
Technical Field
The invention belongs to the technical field of medical dressing, and particularly relates to a waterproof antibacterial quick-film-forming liquid band-aid and a preparation method thereof.
Background
The human skin is the largest organ of the body and is also the first barrier against external bacteria and viruses. In daily life, a human body is often scratched, burned and the like, local bleeding and pus exudation occur to a wound, and new granulation tissues can grow at the wound after a long time and then heal. During recovery, the wound is exposed to air for a long period of time due to the damage of the skin barrier, which prevents the surrounding bacteria-bearing substances from coming into contact. If bacterial and viral attack is caused, wound infection occurs, inflammatory reaction occurs, local inflammation is caused, and even systemic infection through blood is life threatening.
Wound dressings have been documented as early as thousands of years ago for wounds, and healing of wounds is promoted by applying Chinese herbal medicines, leaves, animal fat, etc. to the wounds to form a closed environment. Since the 20 th century, the traditional band-aid has been paid attention to by people due to compression hemostasis, wound surface protection and simple and convenient use, and is extended to the present. However, the traditional band-aid is adhered to the skin by using the flat cloth adhesive, the adhesion is not tight when meeting water or sweat, the effect is not easy to lose, and the gauze soaked in the middle part is not waterproof, so that the wound is sealed and airtight, and bacteria are easy to breed in the wound.
In recent years, liquid band-aids have appeared in the market. The liquid band-aid is formed by dissolving a film-forming material and a functional substance in a solvent, tightly adhering to the wound surface of skin by smearing or spraying, and forming a layer of transparent polymer protective film on the surface of a wound after the solvent is volatilized. The liquid band-aid as a novel wound dressing can cover wounds in any shape and scale, has good flexibility, can quickly form a film under the body temperature condition, and is a novel wound dressing. However, the liquid band-aids currently on the market are more or less subject to some problems and drawbacks: such as slow film forming time, poor film forming effect, easy shedding after long-time use or meeting water, air impermeability, irritation of the components in the film to wounds and the like. Therefore, it is still a challenge to develop a liquid band-aid that has good and rapid film formation, good water-proof and antibacterial effects, and is breathable.
Disclosure of Invention
The invention aims to solve the technical problems of slow film forming time, poor film forming effect, easy falling and air impermeability of the existing liquid band-aid, and provides a waterproof antibacterial liquid band-aid capable of quickly forming a film and a preparation method thereof.
The waterproof antibacterial quick film-forming liquid band-aid provided by the invention comprises the following components in parts by mass: 75% -85%, polyvinyl butyral: 4% -7%, modified cellulose: 4% -7%, castor oil: 9% -12%, polyhexamethylene biguanide hydrochloride: 0.1% to 0.5% and lauramidopropyl betaine: 0.1-0.5 percent, and the sum of the mass of each component is 100 percent.
Further, the polyvinyl butyral is prepared by reacting polyvinyl alcohol aqueous solution, hydrochloric acid and butyraldehyde at 70 ℃.
More specifically, the mass fraction of the polyvinyl alcohol aqueous solution is 8-12%, and the mass ratio of polyvinyl alcohol, hydrochloric acid and butyraldehyde in the polyvinyl alcohol aqueous solution is 100.
Further limited, the preparation process of the modified cellulose comprises the following steps: the fiber is first alkali swelled with sodium hydroxide solution and then modified with stearic acid and ammonium cerium sulfate.
More limited, the alkali swelling process is: adding the fiber into an excessive sodium hydroxide solution, stirring for 10 minutes, then stirring for 4 hours under the condition of 50 ℃ water bath, centrifugally washing until the pH is 6 to 7 to obtain a white opaque colloid, taking out the colloid, adding deionized water, and carrying out ultrasonic treatment for 6 hours to obtain a cellulose suspension.
Further limited, the modification process is: mixing the cellulose suspension with absolute ethyl alcohol, carrying out ultrasonic treatment for 30min, adding stearic acid and ammonium ceric sulfate, carrying out continuous ultrasonic treatment for 30min, stirring for 12h under the condition of 70 ℃ water bath, carrying out magnetic stirring for 5h at normal temperature, after the solution is stable, adding absolute ethyl alcohol with the same volume as the stable solution, centrifuging, and drying to obtain the modified cellulose.
More specifically, the mass of stearic acid is 1% of the mass of the mixed solution of the cellulose suspension and the absolute ethyl alcohol, and the mass of the ammonium cerium sulfate is 1% of the mass of the mixed solution of the cellulose suspension and the absolute ethyl alcohol.
More particularly, the volume ratio of the cellulose suspension to the absolute ethyl alcohol is 1 (6-8).
The preparation method of the waterproof antibacterial quick film-forming liquid band-aid comprises the following steps:
adding polyvinyl butyral into ethanol, stirring at room temperature and 800rpm until the polyvinyl butyral is completely dissolved, then adding modified cellulose, stirring at 1000rpm until the polyvinyl butyral is completely dissolved, ultrasonically discharging bubbles, sequentially adding castor oil, polyhexamethylene biguanide hydrochloride and lauramidopropyl betaine, and continuously stirring at 1000rpm until the castor oil, the polyhexamethylene biguanide hydrochloride and the lauramidopropyl betaine are uniformly mixed to obtain the waterproof, antibacterial and quick-film-forming liquid band-aid.
Compared with the prior art, the invention has the advantages that:
the invention discloses a novel liquid band-aid prepared from polyvinyl butyral, modified cellulose and castor oil. The liquid band-aid has the excellent characteristics of high film forming strength, high film forming speed, soft texture, good waterproof effect, no irritation, good fit with skin, good adhesion, no easy falling and deformation along with bending and extension of the skin at any angle and the like. Meanwhile, the polyhexamethylene guanidine hydrochloride and the lauramidopropyl betaine are added, so that the invasion of bacteria and viruses to wounds is effectively prevented, the wounds are effectively promoted to heal quickly, and the wound healing promoting agent has the following specific advantages:
1) According to the invention, by introducing polyvinyl butyral, the liquid band-aid is coated to quickly form a film within 60 seconds by using the hydrogen bonding effect between a large number of hydroxyl groups in modified cellulose and polyvinyl butyral and amino groups and carboxyl groups in lauramidopropyl betaine, and the strength of the film layer is improved by chemical bonding.
2) According to the invention, the cellulose is modified and is compounded with the castor oil, so that the waterproof performance of the liquid band-aid is obviously improved, and the band-aid has good fitting property with skin, and is not easy to fall off after long-time use and water contact.
3) According to the invention, polyhexamethylene guanidine hydrochloride and lauramidopropyl betaine are adopted as antibacterial materials for compounding, and on one hand, the antibacterial synergistic effect of the polyhexamethylene guanidine hydrochloride and the lauramidopropyl betaine is utilized; polyhexamethylene guanidine, on the other handThe nitrogen in the imino group of the hydrochloride, the hydrogen in the carboxyl group of the lauramidopropyl betaine, the hydrogen in the water molecule, and the hydrogen in the amino group and the oxygen in the carboxyl group can generate the intermolecular hydrogen bonding action, so that the free water molecules in the system are fixed in the liquid band-aid, the free water is dissipated into the air after the liquid band-aid is coated into a film, the whole system has a pore structure, and the existence of the pore structures enables the liquid band-aid to be coated with the H in the air 2 O and CO 2 The air exchange is carried out, the air permeability of the surface of the wound is greatly increased, and the rapid healing of the wound can be promoted.
4) The liquid band-aid is simple and convenient to use, can be quickly formed into a film within 60 seconds when being smeared on a wound at body temperature, can be well attached to the skin, is not easy to fall off along with the bending and extension of the skin at any angle, and can sterilize and diminish inflammation and accelerate the healing of the wound.
Drawings
FIG. 1 is a schematic diagram of the reaction process of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
The experimental procedures used in the following examples are conventional unless otherwise specified. The materials, reagents, methods and apparatus used, unless otherwise specified, are conventional in the art and are commercially available to those skilled in the art.
Example 1: the waterproof antibacterial liquid band-aid capable of quickly forming the film comprises the following components in percentage by mass: 79.1%, polyvinyl butyral: 5%, modified cellulose: 6% and castor oil: 9.6%, polyhexamethylene biguanide hydrochloride: 0.1% and lauramidopropyl betaine: 0.2 percent of the total saponin.
The preparation method of the waterproof antibacterial quick film-forming liquid band-aid comprises the following steps:
preparation of polyvinyl butyral:
adding hydrochloric acid and butyraldehyde into a polyvinyl alcohol aqueous solution with the mass fraction of 10%, reacting for 60min at 70 ℃, washing, neutralizing and drying the obtained precipitate to obtain polyvinyl butyral; the mass ratio of polyvinyl alcohol, hydrochloric acid and butyraldehyde in the polyvinyl alcohol aqueous solution is (100).
Preparing modified cellulose:
(1) Alkali swelling process: adding the fibers into an excessive sodium hydroxide solution, stirring for 10 minutes, then stirring for 4 hours under the condition of a water bath at 50 ℃, centrifugally washing until the pH value is 7 to obtain a white opaque colloid, taking out the colloid, adding deionized water, and carrying out ultrasonic treatment for 6 hours to obtain a white opaque cellulose suspension.
(2) The modification process comprises the following steps: mixing the cellulose suspension with absolute ethyl alcohol according to a volume ratio of 1; the mass of stearic acid is 1% of the mass of the mixed liquid of the cellulose suspension and the absolute ethyl alcohol, and the mass of the ammonium ceric sulfate is 1% of the mass of the mixed liquid of the cellulose suspension and the absolute ethyl alcohol.
Preparing a liquid band-aid:
adding polyvinyl butyral into ethanol according to the ratio of the components in the liquid woundplast, stirring at room temperature and 800rpm until the polyvinyl butyral is completely dissolved, then adding modified cellulose, stirring at 1000rpm until the polyvinyl butyral is completely dissolved, ultrasonically discharging bubbles, sequentially adding castor oil, polyhexamethylene biguanide hydrochloride and lauramide propyl betaine, and continuously stirring at 1000rpm until the mixture is uniformly mixed to obtain the waterproof, antibacterial and quick-film-forming liquid woundplast.
Example 2: the waterproof antibacterial liquid band-aid capable of quickly forming the film comprises the following components in percentage by mass: 79%, polyvinyl butyral: 7%, modified cellulose: 4% and castor oil: 9.4%, polyhexamethylene biguanide hydrochloride: 0.3% and lauramidopropyl betaine: 0.3 percent of the total saponin.
The preparation method of the waterproof antibacterial quick film-forming liquid band-aid comprises the following steps:
preparation of polyvinyl butyral:
adding hydrochloric acid and butyraldehyde into a polyvinyl alcohol aqueous solution with the mass fraction of 10%, reacting for 60min at 70 ℃, washing, neutralizing and drying the obtained precipitate to obtain polyvinyl butyral; the mass ratio of polyvinyl alcohol, hydrochloric acid and butyraldehyde in the polyvinyl alcohol aqueous solution is (100).
Preparing modified cellulose:
(1) Alkali swelling process: adding the fibers into an excessive sodium hydroxide solution, stirring for 10 minutes, then stirring for 4 hours under the condition of a water bath at 50 ℃, centrifugally washing until the pH value is 7 to obtain a white opaque colloid, taking out the colloid, adding deionized water, and carrying out ultrasonic treatment for 6 hours to obtain a white opaque cellulose suspension.
(2) The modification process comprises the following steps: mixing the cellulose suspension with absolute ethyl alcohol according to a volume ratio of 1; the mass of stearic acid is 1% of the mass of the mixed liquid of the cellulose suspension and the absolute ethyl alcohol, and the mass of the ammonium ceric sulfate is 1% of the mass of the mixed liquid of the cellulose suspension and the absolute ethyl alcohol.
Preparing a liquid band-aid:
adding polyvinyl butyral into ethanol according to the ratio of the components in the liquid woundplast, stirring at room temperature and 800rpm until the polyvinyl butyral is completely dissolved, then adding modified cellulose, stirring at 1000rpm until the polyvinyl butyral is completely dissolved, ultrasonically discharging bubbles, sequentially adding castor oil, polyhexamethylene biguanide hydrochloride and lauramide propyl betaine, and continuously stirring at 1000rpm until the mixture is uniformly mixed to obtain the waterproof, antibacterial and quick-film-forming liquid woundplast.
Example 3: the liquid woundplast for waterproof, antibacterial and rapid film formation of the embodiment comprises the following components in percentage by mass: 77%, polyvinyl butyral: 6%, modified cellulose: 6% and castor oil: 10.4%, polyhexamethylene biguanide hydrochloride: 0.2% and lauramidopropyl betaine: 0.4 percent of the total saponin.
The preparation method of the waterproof antibacterial quick film-forming liquid band-aid comprises the following steps:
preparation of polyvinyl butyral:
adding hydrochloric acid and butyraldehyde into a polyvinyl alcohol aqueous solution with the mass fraction of 10%, reacting for 60min at 70 ℃, washing, neutralizing and drying the obtained precipitate to obtain polyvinyl butyral; the mass ratio of polyvinyl alcohol, hydrochloric acid and butyraldehyde in the polyvinyl alcohol aqueous solution is 100.
Preparing modified cellulose:
(1) Alkali swelling process: adding the fibers into an excessive sodium hydroxide solution, stirring for 10 minutes, then stirring for 4 hours under the condition of a water bath at 50 ℃, centrifugally washing until the pH value is 7 to obtain a white opaque colloid, taking out the colloid, adding deionized water, and carrying out ultrasonic treatment for 6 hours to obtain a white opaque cellulose suspension.
(2) The modification process comprises the following steps: mixing the cellulose suspension with absolute ethyl alcohol according to a volume ratio of 1; the mass of stearic acid is 1% of the mass of the mixed liquid of the cellulose suspension and the absolute ethyl alcohol, and the mass of the ammonium ceric sulfate is 1% of the mass of the mixed liquid of the cellulose suspension and the absolute ethyl alcohol.
Preparing a liquid band-aid:
adding polyvinyl butyral into ethanol according to the ratio of the components in the liquid woundplast, stirring at room temperature and 800rpm until the polyvinyl butyral is completely dissolved, then adding modified cellulose, stirring at 1000rpm until the polyvinyl butyral is completely dissolved, ultrasonically discharging bubbles, sequentially adding castor oil, polyhexamethylene biguanide hydrochloride and lauramide propyl betaine, and continuously stirring at 1000rpm until the mixture is uniformly mixed to obtain the waterproof, antibacterial and quick-film-forming liquid woundplast.
Example 4: the liquid woundplast for waterproof, antibacterial and rapid film formation of the embodiment comprises the following components in percentage by mass: 77.5%, polyvinyl butyral: 4%, modified cellulose: 7%, castor oil: 10.8%, polyhexamethylene biguanide hydrochloride: 0.2% and lauramidopropyl betaine: 0.5 percent of the total saponin.
The preparation method of the waterproof antibacterial quick film-forming liquid band-aid comprises the following steps:
preparation of polyvinyl butyral:
adding hydrochloric acid and butyraldehyde into a polyvinyl alcohol aqueous solution with the mass fraction of 10%, reacting for 60min at 70 ℃, washing, neutralizing and drying the obtained precipitate to obtain polyvinyl butyral; the mass ratio of polyvinyl alcohol, hydrochloric acid and butyraldehyde in the polyvinyl alcohol aqueous solution is (100).
Preparing modified cellulose:
(1) Alkali swelling process: adding the fibers into an excessive sodium hydroxide solution, stirring for 10 minutes, then stirring for 4 hours under the condition of a water bath at 50 ℃, centrifugally washing until the pH value is 7 to obtain a white opaque colloid, taking out the colloid, adding deionized water, and carrying out ultrasonic treatment for 6 hours to obtain a white opaque cellulose suspension.
(2) The modification process comprises the following steps: mixing the cellulose suspension with absolute ethyl alcohol according to a volume ratio of 1; the mass of stearic acid is 1% of the mass of the mixed liquid of the cellulose suspension and the absolute ethyl alcohol, and the mass of the ammonium ceric sulfate is 1% of the mass of the mixed liquid of the cellulose suspension and the absolute ethyl alcohol.
Preparing a liquid band-aid:
adding polyvinyl butyral into ethanol according to the ratio of the components in the liquid woundplast, stirring at room temperature and 800rpm until the polyvinyl butyral is completely dissolved, then adding modified cellulose, stirring at 1000rpm until the polyvinyl butyral is completely dissolved, ultrasonically discharging bubbles, sequentially adding castor oil, polyhexamethylene biguanide hydrochloride and lauramide propyl betaine, and continuously stirring at 1000rpm until the mixture is uniformly mixed to obtain the waterproof, antibacterial and quick-film-forming liquid woundplast.
Comparative example 1: the liquid band-aid of the embodiment is prepared from ethanol: 88.7%, polyvinyl butyral: 11%, polyhexamethylene biguanide hydrochloride: 0.1% and lauramidopropyl betaine: 0.2 percent of the total saponin.
The preparation method of the liquid band-aid comprises the following steps:
preparation of polyvinyl butyral:
adding hydrochloric acid and butyraldehyde into a polyvinyl alcohol aqueous solution with the mass fraction of 10%, reacting for 60min at 70 ℃, washing, neutralizing and drying the obtained precipitate to obtain polyvinyl butyral; the mass ratio of polyvinyl alcohol, hydrochloric acid and butyraldehyde in the polyvinyl alcohol aqueous solution is 100.
Preparing a liquid band-aid:
adding polyvinyl butyral into ethanol according to the proportion of each component in the liquid band-aid, stirring at room temperature and 800rpm until the polyvinyl butyral is completely dissolved, sequentially adding polyhexamethylene biguanide hydrochloride and lauramidopropyl betaine after ultrasonic bubble removal, and continuously stirring at 1000rpm until the components are uniformly mixed to obtain the liquid band-aid.
Comparative example 2: the liquid band-aid of the embodiment is prepared from ethanol: 79.2%, polyvinyl butyral: 5%, modified cellulose: 6% and castor oil: 9.8 percent of the medicine.
The preparation method of the liquid band-aid comprises the following steps:
preparation of polyvinyl butyral:
adding hydrochloric acid and butyraldehyde into a polyvinyl alcohol aqueous solution with the mass fraction of 10%, reacting at 70 ℃ for 60min, washing, neutralizing and drying the obtained precipitate to obtain polyvinyl butyral; the mass ratio of polyvinyl alcohol, hydrochloric acid and butyraldehyde in the polyvinyl alcohol aqueous solution is (100).
Preparing modified cellulose:
(1) Alkali swelling process: adding the fibers into an excessive sodium hydroxide solution, stirring for 10 minutes, then stirring for 4 hours under the condition of a water bath at 50 ℃, centrifugally washing until the pH value is 7 to obtain a white opaque colloid, taking out the colloid, adding deionized water, and carrying out ultrasonic treatment for 6 hours to obtain a white opaque cellulose suspension.
(2) The modification process comprises the following steps: mixing the cellulose suspension with absolute ethyl alcohol according to a volume ratio of 1; the mass of stearic acid is 1% of the mass of the mixed liquid of the cellulose suspension and the absolute ethyl alcohol, and the mass of the ammonium ceric sulfate is 1% of the mass of the mixed liquid of the cellulose suspension and the absolute ethyl alcohol.
Preparing a liquid band-aid:
adding polyvinyl butyral into ethanol according to the proportion of each component in the liquid adhesive bandage, stirring at room temperature and 800rpm until the polyvinyl butyral is completely dissolved, then adding modified cellulose, stirring at 1000rpm until the polyvinyl butyral is completely dissolved, adding castor oil after ultrasound bubbling, continuously stirring at 1000rpm until the castor oil is uniformly mixed, and obtaining the liquid adhesive bandage.
Detection test
The liquid band-aids prepared in examples 1 to 4 and comparative examples 1 to 2 were tested for film forming time, water resistance and antibacterial property by the following procedures:
(I) measurement of film formation time.
The test method comprises the following steps: selecting 5 volunteers, taking 0.3g of prepared liquid band-aid samples, respectively smearing the samples on the back skin surfaces of hands of the volunteers, recording the film forming time of the liquid band-aid of each volunteer, and calculating the average time, wherein the results are shown in table 1.
And (II) testing the waterproofness.
Water resistance was determined by inverted cup method: using penicillin bottle with diameter of 15mm, adding 5ml of distilled water, the weight of water is M 1 At this time, the total weight of the water and the bottle is M 0 Covering the surface of the penicillin bottle with the film-forming liquid band-aid, fixing with a rubber band, recording the weight difference of the penicillin bottle before and after 24h, wherein the total weight of water and the bottle after 24h is M 24h . The calculation formula is as follows:
and (III) testing the antibacterial property.
The prepared liquid woundplast sample was tested for its antibacterial activity according to the specifications in the "Disinfection Specification" 2002 edition, 2.1. Antibacterial test, and the results are shown in Table 1.
TABLE 1 liquid Woundplast Properties
| Item | Example 1 | Example 2 | Example 3 | Example 4 | Comparative example 1 | Comparative example 2 |
| Average time(s) of film formation | 48s | 47s | 45s | 50s | 55s | 58s |
| Water repellency (%) | 1.36% | 1.64% | 1.66% | 1.57% | 1.05% | 1.13% |
| Golden grape ball bacteriostasis ring (mm) | 14mm | 15mm | 16mm | 18mm | 13mm | 2mm |
| Escherichia coli inhibition zone (mm) | 12mm | 13mm | 15mm | 17mm | 11mm | 3mm |
As can be seen from the results in Table 1, the liquid band-aid prepared by the invention has the advantages of short film forming time, water resistance and antibacterial property, and has better effect on nursing superficial wounds and small wounds on the surface of human skin.
While the invention has been described with reference to specific preferred embodiments, it is to be understood that the invention is not limited to the disclosed embodiments, but is intended to cover various modifications and alternative embodiments, which may be apparent to those skilled in the art, within the spirit and scope of the invention. Therefore, the protection scope of the present invention should be subject to the protection scope of the claims.
Claims (9)
1. A waterproof antibacterial liquid band-aid capable of quickly forming a film is characterized by comprising the following components in parts by mass: 75% -85%, polyvinyl butyral: 4% -7%, modified cellulose: 4% -7%, castor oil: 9% -12%, polyhexamethylene biguanide hydrochloride: 0.1% to 0.5% and lauramidopropyl betaine: 0.1-0.5 percent, and the sum of the mass of each component is 100 percent.
2. The liquid woundplast of claim 1, wherein the polyvinyl butyral is prepared by reacting polyvinyl alcohol aqueous solution, hydrochloric acid and butyraldehyde at 70 ℃.
3. The liquid woundplast of claim 2, wherein the mass fraction of the aqueous solution of polyvinyl alcohol is 8-12%, and the mass ratio of polyvinyl alcohol, hydrochloric acid and butyraldehyde in the aqueous solution of polyvinyl alcohol is 100.
4. The liquid woundplast of claim 1, wherein the modified cellulose is prepared by the following steps: firstly, carrying out alkali swelling treatment on the fiber by using a sodium hydroxide solution, and then modifying the fiber by using stearic acid and ammonium ceric sulfate.
5. The waterproof antibacterial liquid woundplast capable of being rapidly filmed as claimed in claim 4, wherein the alkali swelling process is as follows: adding the fibers into an excessive sodium hydroxide solution, stirring for 10 minutes, then stirring for 4 hours under the condition of a water bath at 50 ℃, centrifugally washing until the pH value is 6 to 7 to obtain a white opaque colloid, taking out the colloid, adding deionized water, and carrying out ultrasonic treatment for 6 hours to obtain a cellulose suspension.
6. The liquid woundplast of claim 4, wherein the modification process comprises: mixing the cellulose suspension with absolute ethyl alcohol, adding stearic acid and ammonium ceric sulfate after ultrasonic treatment for 30min, continuing ultrasonic treatment for 30min, stirring for 12h under the condition of 70 ℃ water bath, magnetically stirring for 5h at normal temperature, adding absolute ethyl alcohol with the same volume as the stable solution after the solution is stable, centrifuging, and drying to obtain the modified cellulose.
7. The liquid woundplast of claim 6, wherein the stearic acid is 1% by weight of the mixture of the cellulose suspension and the absolute ethyl alcohol, and the ammonium ceric sulfate is 1% by weight of the mixture of the cellulose suspension and the absolute ethyl alcohol.
8. The waterproof antibacterial quick-film-forming liquid band-aid as claimed in claim 6, wherein the volume ratio of the cellulose suspension to the absolute ethyl alcohol is 1 (6-8).
9. The method for preparing the waterproof antibacterial quick film-forming liquid band-aid according to any one of claims 1 to 8, which is characterized by comprising the following steps:
adding polyvinyl butyral into ethanol, stirring at room temperature and 800rpm until the polyvinyl butyral is completely dissolved, then adding modified cellulose, stirring at 1000rpm until the polyvinyl butyral is completely dissolved, performing ultrasonic bubble generation, sequentially adding castor oil, polyhexamethylene biguanide hydrochloride and lauramidopropyl betaine, and continuously stirring at 1000rpm until the castor oil, the polyhexamethylene biguanide hydrochloride and the lauramidopropyl betaine are uniformly mixed to obtain the waterproof, antibacterial and quick-film-forming liquid band-aid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211219661.4A CN115282331B (en) | 2022-10-08 | 2022-10-08 | Waterproof antibacterial liquid band-aid capable of quickly forming film and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211219661.4A CN115282331B (en) | 2022-10-08 | 2022-10-08 | Waterproof antibacterial liquid band-aid capable of quickly forming film and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN115282331A true CN115282331A (en) | 2022-11-04 |
| CN115282331B CN115282331B (en) | 2022-12-13 |
Family
ID=83833886
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211219661.4A Active CN115282331B (en) | 2022-10-08 | 2022-10-08 | Waterproof antibacterial liquid band-aid capable of quickly forming film and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115282331B (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108939145A (en) * | 2018-08-13 | 2018-12-07 | 西安中天生物医药有限公司 | A kind of liquid adhesive bandage and preparation method thereof |
| CN110201218A (en) * | 2018-12-23 | 2019-09-06 | 山东泰开制药有限公司 | Liquid adhesive bandage and preparation method thereof |
| CN110859989A (en) * | 2019-10-25 | 2020-03-06 | 天津冠勤医药科技有限公司 | Liquid band-aid and preparation method thereof |
| CN110903918A (en) * | 2019-11-25 | 2020-03-24 | 广州立白企业集团有限公司 | Antibacterial fabric detergent composition |
-
2022
- 2022-10-08 CN CN202211219661.4A patent/CN115282331B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108939145A (en) * | 2018-08-13 | 2018-12-07 | 西安中天生物医药有限公司 | A kind of liquid adhesive bandage and preparation method thereof |
| CN110201218A (en) * | 2018-12-23 | 2019-09-06 | 山东泰开制药有限公司 | Liquid adhesive bandage and preparation method thereof |
| CN110859989A (en) * | 2019-10-25 | 2020-03-06 | 天津冠勤医药科技有限公司 | Liquid band-aid and preparation method thereof |
| CN110903918A (en) * | 2019-11-25 | 2020-03-24 | 广州立白企业集团有限公司 | Antibacterial fabric detergent composition |
Also Published As
| Publication number | Publication date |
|---|---|
| CN115282331B (en) | 2022-12-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104257639B (en) | A kind of liniment for Wound treating and preparation method thereof | |
| US7125968B2 (en) | Functional chitosan derivative | |
| Zhang et al. | Application status and technical analysis of chitosan-based medical dressings: A review | |
| CN112294661B (en) | High-moisture mask based on cellulose fibers | |
| CN105363066B (en) | A kind of liquid adhesive bandage | |
| CN105797202B (en) | Liquid band-aid and preparation method thereof | |
| CN102552964B (en) | Nano silver chitosan composite antibacterial composition, adhesive bandage and preparation method of adhesive bandage | |
| CN109289084A (en) | A kind of surface of a wound antibacterial liquid dressing and preparation method thereof | |
| CN109369948B (en) | Bacterial cellulose/polyvinyl alcohol antibacterial hydrogel and preparation method and application thereof | |
| CN109498834B (en) | Antibacterial hydrocolloid dressing and preparation method thereof | |
| CN110876814A (en) | Liquid band-aid rich in antibacterial peptide and preparation method thereof | |
| CN111228296A (en) | Cross-linked hyaluronic acid ectoine isotonic wound flushing fluid | |
| CN115282331B (en) | Waterproof antibacterial liquid band-aid capable of quickly forming film and preparation method thereof | |
| CN116549675B (en) | Non-irritating medical ultrasonic coupling agent and preparation method thereof | |
| CN111184906B (en) | PVA-based liquid dressing and preparation method thereof | |
| EP3662937A1 (en) | Hemostatic material and wound dressing material containing same | |
| CN112438964A (en) | Composite antibacterial film spraying agent of lysostaphin and chitosan | |
| CN111991612A (en) | Preparation method of liquid dressing with analgesic and antibacterial functions | |
| CN111012945A (en) | Novel waterproof traditional Chinese medicine liquid band-aid and preparation method thereof | |
| CN103174017A (en) | Sodium alginate oxide modified chitosan fiber and preparation method and application thereof | |
| CN107714677A (en) | A kind of liquid Wound surface protection film and preparation method thereof | |
| CN106937941A (en) | A kind of medical skin diminishing inflammation of wound gel and preparation method thereof | |
| CN105568675A (en) | Preparation method for H type carboxymethyl chitosan fiber | |
| CN114524952B (en) | Preparation method of high-adhesion natural eggshell membrane chitosan hydrogel | |
| CN110301442A (en) | A kind of medical sterilization ultrasonic coupling agent and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20231025 Address after: 1301-397, No. 7299, Airport Road, Changchun Economic and Technological Development Zone, 130000 Jilin Province Patentee after: Jilin Haizhuo Biotechnology Co.,Ltd. Address before: 132000 No. 9, Southwest Ring Road, Fengman Economic Development Zone, Jilin City, Jilin Province Patentee before: Komani (Jilin) Biotechnology Co.,Ltd. |
|
| TR01 | Transfer of patent right |